Alexandria Medical Evidence Library
Library/Viral infections/COVID-19

Viral infections evidence library

COVID-19

A living PubMed evidence library for SARS-CoV-2 prevention, acute COVID-19 treatment, severe disease, post-COVID conditions, and emerging variants.

PubMed only Research ranked Conflicts shown Data downloadable

Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 1,011 non-retracted PubMed-indexed records for COVID-19. The structured collection includes 9 guideline or consensus records, 114 evidence syntheses/systematic reviews/meta-analyses, and 135 randomized or phase III studies. 411 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 812 of 1,011 included records.

Engine 0.3.2 Snapshot v7 Updated 2026-08-31 Download source data · CSV
PubMed records1,011Non-retracted records included
Last 24 months411Records found by the recent-research search
High-priority evidence249Syntheses, reviews, randomized and phase III studies
Effect estimates271Machine-readable values extracted from abstracts
COI statements80.3%Coverage within PubMed records
Funding records257PMIDs with grant/funding metadata
Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years
8
2020
7
2021
18
2022
20
2023
24
2024
41
2025
890
2026
3
2027
Evidence composition

Study designs

Other or unclassified542
Randomized trials127
Preclinical/laboratory79
Meta-analyses64
Systematic reviews50
Cohort studies48
Observational studies29
Prospective cohorts28
Case reports19
Clinical guidelines9
Transparency

Conflict-of-interest reporting

Reported no conflicts392
COI statement present335
Not reported in PubMed record199
Declared financial/industry relationship85

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract908
Neutral/null signal50
Harm signal39
Supportive signal9
Mixed signal5
Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0
0.250.51.02.04.0
not_reported Risk Ratio · PMID 41424145 · 2026
0.85 95% CI 0.80–0.91
not_reported Risk Ratio · PMID 41424145 · 2026
0.87 95% CI 0.79–0.96
not_reported Risk Ratio · PMID 41424145 · 2026
0.93 95% CI 0.76–1.15
not_reported Risk Ratio · PMID 41424145 · 2026
1.35 95% CI 0.85–2.15
not_reported Risk Ratio · PMID 41424145 · 2026
0.79
not_reported Risk Ratio · PMID 41424145 · 2026
0.92 95% CI 0.81–1.04
not_reported Odds Ratio · PMID 41429349 · 2026
0.93
not_reported Odds Ratio · PMID 41429349 · 2026
2.04
not_reported Odds Ratio · PMID 41429349 · 2026
1.78
not_reported Odds Ratio · PMID 41429349 · 2026
2.02
not_reported Odds Ratio · PMID 41496460 · 2026
5.45 95% CI 4.43–6.71
not_reported Odds Ratio · PMID 41496460 · 2026
7.71 95% CI 5.97–9.96
not_reported Odds Ratio · PMID 41496460 · 2026
5.32 95% CI 4.84–5.85
mortality Odds Ratio · PMID 41504189 · 2026
4.66
View extracted numerical results 60
PublicationOutcomeMeasureReported valueSource
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.85 95% CI 0.8–0.91 p < 0.0001 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.87 95% CI 0.79–0.96 p = 0.002 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.93 95% CI 0.76–1.15 p = 0.14 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 1.35 95% CI 0.85–2.15 p = 0.14 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.79 p = 0.0004 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.92 95% CI 0.81–1.04 p = 0.0004 PMID 41424145
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 0.93 PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 2.04 PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 1.78 PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 2.02 PMID 41429349
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026 not_reported Odds Ratio 5.45 95% CI 4.43–6.71 PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026 not_reported Odds Ratio 7.71 95% CI 5.97–9.96 PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026 not_reported Odds Ratio 5.32 95% CI 4.84–5.85 PMID 41496460
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026 mortality Odds Ratio 4.66 PMID 41504189
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026 mortality Odds Ratio 3.34 PMID 41504189
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 1.19 95% CI 0.7–2.01 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 5.48 95% CI 0.7–43.09 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.4 95% CI 0.17–0.97 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.43 95% CI 0.18–1.06 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.15 95% CI 0.04–0.54 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.12 95% CI 0.03–0.47 PMID 41571287
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 100.0 PMID 41627968
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026 adverse events Odds Ratio 2.0 PMID 41627968
The role of age, sex, and ethnicity in vaccine trust, and sources of information in Canada: Findings from a national survey.Human vaccines & immunotherapeutics · 2026 not_reported Percentage Comparison 87.0percent vs 83.0percent PMID 41640305
Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 not_reported Odds Ratio 0.75 p = .036 PMID 42420160
Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 25.0 PMID 42268674
Household Transmission of SARS-CoV-2 in Washington and Oregon, United States, 2022-2024.Journal of the Pediatric Infectious Diseases Society · 2026 not_reported Risk Ratio 1.88 PMID 42476513
Household Transmission of SARS-CoV-2 in Washington and Oregon, United States, 2022-2024.Journal of the Pediatric Infectious Diseases Society · 2026 not_reported Risk Ratio 1.85 PMID 42476513
Household Transmission of SARS-CoV-2 in Washington and Oregon, United States, 2022-2024.Journal of the Pediatric Infectious Diseases Society · 2026 not_reported Risk Ratio 2.15 PMID 42476513
Deucravacitinib 5-Year Safety and Efficacy Results in Plaque Psoriasis: A Phase 3 Open-Label Extension of Randomized Clinical Trials.American journal of clinical dermatology · 2026 not_reported Odds Ratio 1.0 PMID 42563042
Deucravacitinib 5-Year Safety and Efficacy Results in Plaque Psoriasis: A Phase 3 Open-Label Extension of Randomized Clinical Trials.American journal of clinical dermatology · 2026 not_reported Odds Ratio 1.0 PMID 42563042
The WORKWELL programme: a randomized controlled trial of job retention vocational rehabilitation for people with inflammatory arthritis.Rheumatology (Oxford, England) · 2026 not_reported Odds Ratio 36.0 P = 0.53 PMID 42467833
Associations between maternal lipid metabolism in early pregnancy and postpartum symptoms of depression and anxiety: results from a longitudinal cohort of 266 women.Journal of psychiatric research · 2026 not_reported Odds Ratio 1.65 95% CI 1.22–2.1 PMID 42497820
Retronasal Olfactory Function After Olfactory Training: A Prospective Single-Arm Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026 not_reported Odds Ratio 4.0 p = 0.024 PMID 42587340
Functional dyspnea as an early marker of vulnerability to persistent physical symptoms in the CONSTANCES population-based cohort.Journal of psychosomatic research · 2026 not_reported Odds Ratio 1.79 p < 0.001 PMID 42247774
Low prevalence of bacterial coinfection at hospital admission in COVID-19 and the role of procalcitonin as a rule-out biomarker.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 mortality Odds Ratio 28.0 PMID 42349772
Low prevalence of bacterial coinfection at hospital admission in COVID-19 and the role of procalcitonin as a rule-out biomarker.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 not_reported Odds Ratio 4.31 95% CI 2.35–7.84 PMID 42349772
Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.Journal of affective disorders · 2026 not_reported Odds Ratio 0.72 PMID 42203050
Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.Journal of affective disorders · 2026 not_reported Odds Ratio 0.69 PMID 42203050
Cardiovascular Involvement and Its Association with Disease Severity and Recovery in SARS-CoV-2 Associated Multisystem Inflammatory Syndrome in Children.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2026 not_reported Hazard Ratio 0.48 PMID 42284067
Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage80.3%199 records have no COI statement exposed in PubMed.
Funding metadata coverage25.4%Coverage indicates whether grant/funding metadata was present, not independence or study quality.
Most frequently reported funding agencies
NIH HHS53
NIAID NIH HHS44
NCI NIH HHS23
NHLBI NIH HHS21
NCATS NIH HHS20
NIA NIH HHS18
NIDDK NIH HHS17
National Natural Science Foundation of China15
View records with declared financial or industry relationships 12

Clinical practice guideline for long COVID prevention and treatment.

Conflict of interest: B. Cao is a member of the European Respiratory Journal editorial board. J.B. Soriano reports grants from Linde via Hospital Universitario de La Princesa, consultancy fees from ERS and SEPAR, participation in speaking activities, advisory committees and consultancies for Air Liquide, Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, ERS, Grifols, GSK, Linde, Lipopharma, Mundipharma, Novartis, Pfizer, RiRL, Rovi, SEPAR and Takeda, a leadership role for the Spanish Network of Research in Long COVID (REiCOP), and is an Associate Editor for the European Respiratory Journal. R. Paredes reports participation in an advisory board with Pfizer, Gilead and AstraZeneca. R.A. Evans reports grants from Genentech/Roche, lecture fees from Moderna, and fees for participation on an advisory board for the UK National COVID Inquiry. M.J. Peluso reports consultancy fees from Gilead Sciences and AstraZeneca. J.D. Chalmers reports grants or contracts from AstraZeneca, Chiesi, Genentech, Gilead Sciences, GlaxoSmithKline, Insmed, Grifols, Trudell, Verona and Boehringer Ingelheim, and consulting fees from AstraZeneca, Biomx, Chiesi, CSL Behring, Expedition, GlaxoSmithKline, Insmed, Grifols, Boehringer Ingelheim, Pfizer, Sanofi/Regeneron and Zambon, and is the Chief Editor of the European Respiratory Journal. Y. Chen is the co-founder and co-chair of the RIGHT (Reporting Items for Practice Guidelines in Healthcare) working group. The remaining authors have no potential conflicts of interest to disclose.

PMID 41856572 · 2026

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Vivek Shinde, Wayne Woo, Susan Neal, Joyce S. Plested, Mingzhu Zhu, Shane Cloney-Clark, Iksung Cho, and Raburn M. Mallory are employees of Novavax, Inc. and may hold Novavax, Inc. stock. Anthony M. Marchese, Timothy S. Vincent, Louis Fries, and Greg Glenn are former employees of Novavax, Inc. and may hold Novavax, Inc. stock.

PMID 42390526 · 2026

Effect of nipocalimab on IgG responses to vaccinations and viral infections in patients with IgG autoantibody-mediated diseases: Post hoc analyses of three randomized, placebo-controlled trials.

FY, EM, BN, CBM, MC, KF, QW, JJH, KC, SR, RRC, RE, CC, MJL, DD, and SG are employees of Johnson & Johnson and may hold stock options in Johnson & Johnson. PCT has served on Data and Safety Monitoring Boards for Immunovant, Sanofi, and MoonLake; served as a consultant for AbbVie, Alfasigma, Aqtual, Biogen, Eli Lilly, Fresenius, Gilead Sciences, Janssen, Nordic Pharma, Roche, Takeda, and UCB; and received grants/research support from Alfasigma. J-EG has served as a consultant for AbbVie, Bristol Myers Squibb, Galapagos, Gilead Sciences, Johnson & Johnson, Eli Lilly, MSD, Novartis, Pfizer, Sanofi, and UCB. GN has served as a consultant for Johnson & Johnson, Novartis, argenx, and Amgen; received research or grant support related to SjD and systemic lupus erythematosus from LuCIN network, Novartis, Janssen, Amgen, Bristol Myers Squibb, Pfizer, Sanofi, and Horizon. TV has received research or grant support related to myasthenia gravis from Alexion, AstraZeneca Rare Disease, Amgen, argenx, Cartesian Therapeutics, COUR, Dianthus Therapeutics, Immunovant, Johnson & Johnson, NMD Pharma, Regeneron, and UCB; and served as a consultant or on a speakers bureau for Alexion, AstraZeneca Rare Disease, Amgen, argenx, CSL Behring, Dianthus Therapeutics, Johnson & Johnson, and Takeda. CA received funding for travel, meeting attendance, and advisory board participation from Alexion, Momenta, Sanofi, argenx, UCB, and Johnosn & Johnson. KLW received consulting fees from AbbVie, AstraZeneca, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead, GSK, Moderna, Novartis, Roche, Sanofi, UCB, Zura Bio, Takeda, Ouro Medicines, and Otsuka.

PMID 42084498 · 2026

NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants.

Young reports personal fees from Astra-Zeneca, Gilead, Moderna, Pfizer and Sanofi outside the submitted work. Wang disclose that a patent (Patent No.: US 11,054,429 B1) was issued for the surrogate virus neutralisation test platform (cPass kit) used in this study, and declare royalty payment from GenScript for inventing the technology. All other authors no potential conflicts of interest.

PMID 42083894 · 2026

Exploring the experiences and perceptions of co-administration of routine vaccines in adults: Findings from an embedded qualitative study with participants and research delivery staff in the ZosterFluCov randomized controlled trial.

This work was funded by an investigator initiated grant from GSK. SR’s and VW’s time was funded by an investigator led grant from GSK. RL has received financial compensation from Sanofi for participating in a influenza vaccine advisory board in 2023 and from Astra Zeneca for a conference presentation in 2022. HS has previously received funding for investigator driven research from Moderna and funding to attend COVID-19 related advisor boards and to present at conferences from Pfizer.

PMID 41734040 · 2026

Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.

FN owns some AstraZeneca shares. FN and AS have research project support (paid to his institution, no personal fees) from Bayer, with no relation to the work reported here. All authors have completed the Unified Competing Interest form (available on request from the corresponding author) and declare: no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work.

PMID 41496460 · 2026

Impact of Age on Bleeding, Stroke, and Mortality in Edoxaban-Treated Patients with Atrial Fibrillation: Results from the ETAF-TR Registry.

Declarations. Conflict of interest: The ETAF-TR study was funded by Daiichi Sankyo Türkiye. No author received personal fees, honoraria, or other direct compensation from Daiichi Sankyo in relation to this manuscript. On behalf of the ETAF-TR Investigators, Associate Professor Oguzhan Celik declares that no other conflicts of interest relevant to the contents of this manuscript exist. Authors’ contributions: Conceptualization: UOT; data curation: OC and TT; formal analysis: SK and OB; investigation: OB and OC; methodology: OC and UOT; project administration: OB and OC; writing—original draft: OC, OB, and UOT; and writing—review and editing: all authors. Data availability: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. Ethics approval: The ETAF-TR study protocol was approved by the local ethics committee (513-SBKAEK, 2020/04-01) and the Turkish Medicines and Medical Devices Agency (TITCK) in March 2020. Consent to participate: Informed consent was obtained from all participants included in the study. Consent for publication: All authors have approved the final version of the manuscript for publication. Code availability: Not applicable.

PMID 42455491 · 2026

Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study.

The following authors declare these potential conflicts of interest: S.H.–Research grant from Takeda and Janssen in the past 3 years. No conflict for this study. V.M.N.-L.–Consultation fee, research grant, royalties, or honorarium from Ordesa, Adacyte, Nutricia, Pfizer, AbbVie, Takeda, and Nestlé Health Science. S.L.–Educational fees from Takeda and McKesson outside the submitted work. H.J.R.–Nutricia, Semper and Adacyte for research support and speaker fee. None of those have any relation to the present study. A.O.–Research support and advisory board for AbbVie, research site for AbbVie, Janssen, Pfizer, Eli Lilly. F.J.M.C.–Honoraria for talks and advisory from Abbvie, Nestlé Health Science, MSD, Adacyte, Janssen. O.O.–Dr. Olén has been PI on projects at Karolinska Institutet financed by grants from Janssen, Takeda, AbbVie, Pfizer, Bristol Myers Squibb, and Ferring, and also report grants from Pfizer, AbbVie, Galapagos, and Janssen in the context of national safety monitoring programs. None of those studies have any relation to the present study. J.V.L.–Nestlé Health Sciences consulting/research support/speaker fee and Janssen (Research Support/Travel). R.S.B.–Received funds for consulting or speaker—from Nestlé Health Science, Takeda, Megapharm and Janssen; serves on advisory board for Evinature. E.W.–Advisory board: AbbVie, Nestlé Health Science, Pfizer, BioJamp; Speaker: AbbVie, Nestlé Health Science, Janssen, Mead Johnson Nutrition. G.P.M., A.McQ., G.H., and R.J.W., no conflicts to declare.

PMID 42322204 · 2026
01

Current Standard-of-Care Sources

Alexandria uses this label only for PubMed-indexed guidelines or consensus documents. These are source publications, not individualized recommendations.

02

Highest-Priority Research

meta analysisn=135762

Systematic review and meta-analysis of artificial intelligence models for diagnosing and subphenotyping ARDS in adults.

Heart & lung : the journal of critical care · 2026

BACKGROUND: Artificial intelligence (AI) has emerged as a promising tool to improve the diagnosis and characterization of ARDS, including the identification of subphenotypes. OBJECTIVES: To evaluate the diagnostic performance and methodological quality of AI models for identifying ARDS and its subphenotypes in adults. METHODS: We conducted a systematic review and meta-analysis of 63 studies (n = 135,762) published between 2013 and 2024 in PubMed, Embase, and the Cochrane Library. Extracted outcomes included sensitivity, specificity, AUROC, and validation methods. Risk of bias was assessed with PROBAST, and AI-specific metrics (overfitting, generalization, interpretability, discrimination, ca…

PMID 41037977
clinical guideline

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026

BACKGROUND: This guideline aims to address key clinical questions of long COVID, and to provide evidence-based recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses and general practitioners in community healthcare institutions worldwide. METHODS: The guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinary working group was established and comprised 60 members from 10 countries and 10 areas of expertise, with a strong background in long COVID research and clinical practice, and met…

PMID 41856572
clinical guideline

Pragmatic management of acute cough in children and adolescents: an updated position paper by the Italian Society of Pediatric Allergy and Immunology (SIAIP).

Allergologia et immunopathologia · 2026

BACKGROUND: Cough is one of the most common and distressing symptoms in pediatric practice and represents a major cause of medical consultation, parental anxiety, and inappropriate medication use. Although most acute cough episodes are benign and self-limiting, they can significantly affect child's sleep, school performance, and quality of life. The COVID-19 pandemic and subsequent changes in infection patterns and immune responses have further highlighted the need to update the existing clinical guidance. OBJECTIVE: This joint position paper by the Italian Society of Pediatric Allergy and Immunology (SIAIP) aims to provide a pragmatic, evidence-based update on the management of acute and po…

PMID 42115792
clinical guideline

COVID-19 Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians.

Annals of internal medicine · 2026

DESCRIPTION: The American College of Physicians (ACP) developed these rapid practice points addressing the effectiveness, comparative effectiveness, and harms of Omicron-adapted COVID-19 vaccines in adults (aged ≥18 years) who are not pregnant or immunocompromised. METHODS: The ACP Population Health and Medical Science Committee developed the rapid practice points on the basis of a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria and national disease surveillance data on the epidemiology and baseline risks for COVID-19. UNLABELLED: The following practice points apply to those who are not pregnant or immunocompromised. PRACTICE POINT 1: Adults aged 65 years or older sho…

PMID 41730216
meta analysisn=323440

Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.

Journal of affective disorders · 2026

BACKGROUND: Depression and anxiety constitute a global health crisis, with prevalence increasing by 27.6% during the COVID-19 pandemic. The 24-Hour Movement Guidelines, integrating physical activity, sedentary behavior, and sleep, have been linked to improved mental health, yet no meta-analysis has quantified these associations. METHODS: Following PRISMA guidelines, PubMed, Embase, Cochrane Library, and Web of Science were searched through January 1, 2026. Observational studies examining adherence to the 24-Hour Movement Guidelines and anxiety or depression were included. Cross-sectional and cohort studies were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools, with t…

PMID 42203050
meta analysisn=380191

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Preventive medicine · 2026

OBJECTIVE: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D) and a marker of delayed diagnosis, associated with significant morbidity, mortality, and healthcare costs. Global estimates of DKA at T1D onset remain inconsistent. METHODS: We conducted a systematic review and meta-analysis, searching PubMed (1996), Web of Science (1966), Embase (1947), and Scopus (1980), each from its inception to October 2025, without restrictions. Studies reporting DKA prevalence at diagnosis in individuals <19 years with newly diagnosed T1D were included. Pooled prevalence was calculated using random-effects meta-analysis. Subgroup analyses explored variations by country, …

PMID 42303108
clinical guideline

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026

This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The panel also provides a section on how to apply…

PMID 41920902
clinical guideline

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents a new recommendation on the use of baricitinib vs. tocilizumab in hospitalized adults with severe or critical COVID-19. The panel has previously issued recommendations on baricitinib vs. no baricitinib and tocilizumab vs. no tocilizumab, but this new recommendation compares baricitinib to tocilizumab when the decision has been made to give one or the other. The new recommendation does not address combinations of multiple immunomodulatory agents (ie, baricitinib, tocilizumab, a…

PMID 41920901
clinical guideline

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026

Immunocompromised individuals experience disproportionately severe outcomes from respiratory syncytial virus (RSV) infection, yet direct evidence to guide vaccination in this population remains limited. To support clinical and shared decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary expert panel to develop rapid, evidence-based recommendations on RSV vaccination among immunocompromised adults and children. The panel conducted a systematic review of comparative effectiveness and harms data published between August 2024 and July 2025, supplemented by additional evidence from the Vaccine Integrity Project. …

PMID 41766598
clinical guideline

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19, Influenza, and RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026

Respiratory viruses-including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19), respiratory syncytial virus (RSV), and influenza-pose significant risks to immunocompromised patients, who experience attenuated vaccine responses and higher morbidity. To address evolving vaccine recommendations for the 2025-2026 season, the Infectious Diseases Society of America (IDSA), in collaboration with the Vaccine Integrity Project (VIP) and partner organizations, developed rapid guidelines for US-licensed vaccines targeting these viruses. The guideline applies to adults and children with compromised immunity due to hematologic malignancy, solid organ or hematopoietic cell transpla…

PMID 41766454
clinical guideline

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19 Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026

Immunocompromised individuals face elevated risks of severe COVID-19, yet vaccination guidance for these populations continues to evolve. To support evidence-based decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary panel to develop rapid guidelines on the use of US-licensed COVID-19 vaccines in adults and children with hematologic malignancies, primary immunodeficiency, autoimmune disease on immunosuppressive therapy, HIV with severe immunosuppression, solid organ transplantation, hematopoietic cell transplantation (HCT), chimeric antigen receptor T-cell therapy (CAR-T), or solid tumor chemotherapy. A sys…

PMID 41739597
clinical guideline

HRS/ACC scientific statement: Guiding principles on same-day discharge for intracardiac catheter ablation procedures.

Heart rhythm · 2025

Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown. Access challenges (exacerbated during the COVID-19 public health emergency) and economic pressures have driven a shift in practice trends to reduce hospitalization duration and optimize resource utilization. A same-day discharge (SDD) strategy has increasingly been used to address these challenges. Incorpor…

PMID 40272340
03

Latest Research — Last 24 Months

04

Treatment Options Studied in the PubMed Collection

These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.

higher-confidence evidence

COVID-19 Vaccines

96 linked PMIDs249690 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, mortality, long COVID, hospitalization, overall survival
Populations represented
general population; children; severe COVID-19; older adults; neutralizing antibody; first-line
Mechanism
Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Current SARS-CoV-2 vaccines primarily elicit antibodies targeting the variable receptor-binding domain in the S1 subunit of the spike protein, resulting in limited cross-reactivity and short-lived immunity against emerging variants
PMID 39971395PMID 41785679PMID 41630128PMID 42057741PMID 42640841PMID 36596943PMID 37997650PMID 41734040
higher-confidence evidence

Antibodies, Viral

45 linked PMIDs59324 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, mortality
Populations represented
general population; neutralizing antibody; severe COVID-19; children; first-line; SARS-CoV-2 RNA
Mechanism
Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Current SARS-CoV-2 vaccines primarily elicit antibodies targeting the variable receptor-binding domain in the S1 subunit of the spike protein, resulting in limited cross-reactivity and short-lived immunity against emerging variants
PMID 41785679PMID 41947067PMID 41875666PMID 34260780PMID 42084498PMID 35880305PMID 42361783PMID 42574393
higher-confidence evidence

COVID-19 vaccine

40 linked PMIDs123715 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, hospitalization, mortality
Populations represented
general population; children; older adults; neutralizing antibody; severe COVID-19; severe COVID-19; older adults
Mechanism
To investigate which pre-pandemic domains account for the steeper CEE gradient, we add conceptually motivated blocks of covariates capturing cognitive resources, social capital, social networks, health, and early-life circumstances Neutralizing antibody titers (pseudovirus 50% neutralization titer, NT50) and anti-spike IgG (BAU/mL) were assessed pre-dose (Day 1) and post-vaccination through 12 months; a predefined subset underwent IFN-γ and IL-5 ELISpot
PMID 41785679PMID 42057741PMID 42640841PMID 37997650PMID 41680545PMID 41565103PMID 42430873PMID 42664197
limited evidence

Spike Glycoprotein, Coronavirus

35 linked PMIDs5858 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events
Populations represented
general population; neutralizing antibody; severe COVID-19; first-line; severe COVID-19; older adults; early-stage
Mechanism
The primary targets of SARS-CoV-2 are lung cells, where viral-host interactions trigger extensive molecular and structural changes This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome
PMID 42361783PMID 41310146PMID 42287949PMID 42302372PMID 42361718PMID 41289153PMID 42473006PMID 42642437
limited evidence

spike protein, SARS-CoV-2

27 linked PMIDs5141 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events
Populations represented
general population; severe COVID-19; severe COVID-19; older adults; early-stage
Mechanism
This integrated, one-pot, and scalable platform provides a versatile strategy for fast, sensitive, and multimodal nucleic acid detection applicable to diverse targets This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome
PMID 42330669PMID 42287949PMID 42361718PMID 41289153PMID 42642437PMID 42519305PMID 42372164PMID 42589407
limited evidence

Antiviral Agents

24 linked PMIDs42400 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, long COVID, mortality, mechanical ventilation, adverse events, hospitalization
Populations represented
general population; long COVID; neutralizing antibody; localized
Mechanism
Viruses and their hosts utilize miRNAs for regulating gene expression, targeting both cellular and viral mRNAs Thus, it offers promising new potential molecular targets for therapeutic development, complementing existing antiviral strategies
PMID 41943156PMID 42455170PMID 42589407PMID 42331085PMID 42385347PMID 42557548PMID 42653958PMID 40298378
moderate-confidence evidence

Antibodies, Neutralizing

23 linked PMIDs45618 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, mortality
Populations represented
general population; neutralizing antibody; neutralizing antibody; children
Mechanism
Benefits of these engagers include the ease of manufacturing, stability, more cell-specific targeting, and high affinity binding to Fc receptors In response to this, the advancement of next-generation vaccines against COVID-19 targeting components from new subvariants such as XBB-lineage is imperative
PMID 41785679PMID 41310146PMID 42633788PMID 42519305PMID 42545256PMID 42423335PMID 42585813PMID 40000611
moderate-confidence evidence

Immunoglobulin G

16 linked PMIDs5266 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, mortality
Populations represented
general population; children; first-line; neutralizing antibody
Mechanism
Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions We systematically compared their clinical symptoms, serum anti-RBD IgG levels, and neutralizing antibody (NAb) geometric mean titers (GMTs) against Omicron BA.4/5 and XBB.1.5 using a pseudovirus neutralization assay
PMID 42084498PMID 42361783PMID 41310146PMID 42184776PMID 42118165PMID 42585813PMID 41605700PMID 42378814
limited evidence

RNA, Messenger

13 linked PMIDs2092 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population; neutralizing antibody; localized; advanced; neutralizing antibody
Mechanism
Preclinical and clinical studies now demonstrate potent and durable immune responses elicited by LNP-mRNA vaccines against diverse viral, bacterial, and cancer targets Prior studies showed that spike (S)-EABR mRNA-LNP immunizations elicited enhanced neutralizing antibody responses against ancestral and variant SARS-CoV-2 compared with conventional S mRNA-LNP in naïve mice, but the effectiveness of S-EABR mRNA-LNP boosters in the context of pre-existing immunity has not been investigated
PMID 41984833PMID 42430841PMID 42361911PMID 42653382PMID 40774368PMID 42116071PMID 41962202PMID 42611746
limited evidence

Biomarkers

13 linked PMIDs1830 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, hospitalization, long COVID
Populations represented
general population; severe COVID-19; severe COVID-19; older adults; children; long COVID
Mechanism
Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment Conclusion: ZNF281 and LRRN3 may regulate immune pathways (T cells, NK cells, macrophages), influencing IA-related SAH development, and could serve as therapeutic targets
PMID 41263641PMID 40267124PMID 42361718PMID 42322969PMID 42470742PMID 42622704PMID 41362990PMID 42329789
higher-confidence evidence

Vaccines, Synthetic

12 linked PMIDs1919 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
adverse events, reported clinical outcomes, serious adverse events, mortality
Populations represented
general population; severe COVID-19; severe COVID-19; older adults
Mechanism
In response to this, the advancement of next-generation vaccines against COVID-19 targeting components from new subvariants such as XBB-lineage is imperative While the original mRNA COVID-19 vaccine, mRNA-1273, targets the full-length SARS-CoV-2 spike protein, mRNA-1283 is a novel next-generation mRNA COVID-19 vaccine that specifically targets immunodominant domains within the spike protein
PMID 41627968PMID 42647564PMID 42378814PMID 42268674PMID 42155675PMID 42361783PMID 41310146PMID 42423335
preliminary evidence

Cytokines

12 linked PMIDs181 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, long COVID, mortality
Populations represented
general population; long COVID; severe COVID-19; viral load; children
Mechanism
In this study, we evaluated the effects of combining Nirmatrelvir (a SARS-CoV-2 main protease inhibitor) with Ivermectin, Azithromycin or Doxycycline-using a murine hepatitis virus (MHV) infection model of RAW264.7 macrophages This combination achieved potent inhibition of live virus titer of at least 5 to 6 log10 and reduction in viral RNA load of 3 log10, at drug concentrations much lower than the respective monotherapies
PMID 34260780PMID 42585251PMID 42653319PMID 39530101PMID 42665974PMID 42645657PMID 32712333PMID 42619233
limited evidence

Angiotensin-Converting Enzyme 2

12 linked PMIDs19 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population; neutralizing antibody
Mechanism
Furthermore, by binding to SARS-CoV-2, the protein not only inhibits viral entry but also redirects the virus to macrophages for enhanced immune clearance Benefits of these engagers include the ease of manufacturing, stability, more cell-specific targeting, and high affinity binding to Fc receptors
PMID 42287949PMID 42473006PMID 42633788PMID 42642437PMID 42455170PMID 42585251PMID 42335857PMID 42331085
moderate-confidence evidence

BNT162 Vaccine

11 linked PMIDs769 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
adverse events, reported clinical outcomes, mortality, hospitalization
Populations represented
general population; severe COVID-19; older adults; neutralizing antibody
Mechanism
BACKGROUND: Using adapted COVID-19 vaccines targeting current variants in circulation is necessary for addressing the dynamic evolution of the SARS-CoV-2 virus and protecting against emerging variants RESEARCH DESIGN AND METHODS: Using a previously published, combined Markov-decision tree model adapted for Costa Rica, this study estimated the outcomes of different vaccination strategies with BNT162b2 COVID-19 mRNA vaccine, targeting various age and risk groups
PMID 41700320PMID 41848549PMID 42435835PMID 42661284PMID 42361783PMID 42118165PMID 42322683PMID 42625910
limited evidence

RNA, Viral

10 linked PMIDs— reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, mortality, hospitalization
Populations represented
general population; SARS-CoV-2 RNA
Mechanism
The NeuMoDx™ assay demonstrated strong correlations between Ct values and viral RNA concentrations, with R² values of 0.9971 and 0.9952 for the N and Nsp2 targets, respectively Intra-run precision showed low variability, with standard deviations of 0.23 and 0.34 at 500 copies/mL for the N and Nsp2 targets, respectively
PMID 42309186PMID 42361718PMID 42649161PMID 42322970PMID 39838754PMID 42524883PMID 42655652PMID 42247945
moderate-confidence evidence

Influenza Vaccines

9 linked PMIDs66139 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization
Populations represented
general population; older adults; children
Mechanism
Not explicitly reported in the retrieved PubMed metadata or abstracts.
PMID 41734040PMID 41686169PMID 42605756PMID 41627968PMID 41661551PMID 41665459PMID 41843918PMID 41814863
limited evidence

mRNA Vaccines

9 linked PMIDs615 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events
Populations represented
general population; advanced; neutralizing antibody
Mechanism
Preclinical and clinical studies now demonstrate potent and durable immune responses elicited by LNP-mRNA vaccines against diverse viral, bacterial, and cancer targets Notably, SLNPs induce neutralizing antibody titers against the SARS-CoV-2 spike protein that are comparable to those achieved with significantly higher doses of conventional LNPs, highlighting their substantial dose-sparing potential
PMID 41310146PMID 41984833PMID 42361911PMID 42653382PMID 40774368PMID 41962202PMID 40498855PMID 42647564
limited evidence

ACE2 protein, human

9 linked PMIDs19 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population
Mechanism
Furthermore, by binding to SARS-CoV-2, the protein not only inhibits viral entry but also redirects the virus to macrophages for enhanced immune clearance Benefits of these engagers include the ease of manufacturing, stability, more cell-specific targeting, and high affinity binding to Fc receptors
PMID 42287949PMID 42473006PMID 42633788PMID 42642437PMID 42455170PMID 42331085PMID 42644401PMID 42034607
05

Conflicting Research

higher-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

87 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 81benefit: 1harm: 3null: 2
PMID 39971395PMID 41785679PMID 41630128PMID 42057741PMID 42220116PMID 42531981PMID 42480193PMID 42486052PMID 42640841PMID 42390526
higher-confidence evidence

Antibodies, Viral · multiple reported outcomes

43 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 38harm: 3benefit: 1null: 1
PMID 41785679PMID 42220116PMID 41947067PMID 41875666PMID 42531981PMID 42480193PMID 42390526PMID 41627968PMID 42647564PMID 34260780
higher-confidence evidence

COVID-19 vaccine · multiple reported outcomes

36 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 32harm: 3null: 1
PMID 41785679PMID 42057741PMID 42220116PMID 42486052PMID 42640841PMID 42647564PMID 37997650PMID 41680545PMID 41565103PMID 42430873
higher-confidence evidence

Antibodies, Neutralizing · multiple reported outcomes

23 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 20benefit: 1null: 1harm: 1
PMID 41785679PMID 42220116PMID 42647564PMID 42520645PMID 42378814PMID 36411267PMID 41569047PMID 42268674PMID 41700320PMID 42227026
higher-confidence evidence

Antiviral Agents · multiple reported outcomes

21 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 18null: 1mixed: 2
PMID 40067859PMID 42017206PMID 42316440PMID 39819859PMID 42654463PMID 41943156PMID 42455170PMID 42589407PMID 42331085PMID 42385347
moderate-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

8 studies

Status: apparently conflicting; different clinical questions. Population: children. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 6harm: 1null: 1
PMID 42364277PMID 41911278PMID 42053343PMID 42223472PMID 41814863PMID 41608973PMID 42535943PMID 42027105
higher-confidence evidence

remdesivir · multiple reported outcomes

5 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
null: 1unknown: 3mixed: 1
PMID 40067859PMID 42017206PMID 42316440PMID 42455170PMID 42385347
higher-confidence evidence

Adenosine Monophosphate · multiple reported outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
null: 1unknown: 2mixed: 1
PMID 40067859PMID 42017206PMID 42316440PMID 42455170
moderate-confidence evidence

Drug Combinations · multiple reported outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 2mixed: 1null: 1
PMID 36411267PMID 42536986PMID 39819859PMID 42654463
preliminary evidence

Ritonavir · multiple reported outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 1mixed: 1
PMID 39819859PMID 42654463
preliminary evidence

Proline · multiple reported outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 1mixed: 1
PMID 39819859PMID 42654463
moderate-confidence evidence

Alanine · multiple reported outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 1mixed: 1
PMID 40067859PMID 42316440
06

Failed or Negative Trials

07

Emerging and Experimental Research

08

Evidence Gaps

Detailed risk-of-bias assessment remains limited

PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.

R

Complete Ranked PubMed Index

The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.

Current Standard Of Care127 records
Rank116.0
Clinical guideline or consensus statement

Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021.

Annals of oncology : official journal of the European Society for Medical Oncology · 2021 · PMID 34242744

The 17th St Gallen International Breast Cancer Consensus Conference in 2021 was held virtually, owing to the global COVID-19 pandemic. More than 3300 participants took part in this important bi-annual critical review of the 'state of the art' in the multidisciplinary care of early-stage breast cancer. Seventy-four expert panelists (see Appendix 1) from all continents discussed and commented on the previously elaborated consensus questions, as well as many key questions on early breast cancer diagnosis and treatment…

Rank112.0
Clinical guideline or consensus statement

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026 · PMID 41856572

BACKGROUND: This guideline aims to address key clinical questions of long COVID, and to provide evidence-based recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses and general practitioners in community healthcare institutions worldwide. METHODS: The guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinar…

Rank110.0
Clinical guideline or consensus statementResult signal: harm

COVID-19 Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians.

Annals of internal medicine · 2026 · PMID 41730216

DESCRIPTION: The American College of Physicians (ACP) developed these rapid practice points addressing the effectiveness, comparative effectiveness, and harms of Omicron-adapted COVID-19 vaccines in adults (aged ≥18 years) who are not pregnant or immunocompromised. METHODS: The ACP Population Health and Medical Science Committee developed the rapid practice points on the basis of a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria and national disease surveillance data on the epidemiology and …

Rank110.0
Clinical guideline or consensus statement

Society of Critical Care Medicine Guidelines on Family-Centered Care for Adult ICUs: 2024.

Critical care medicine · 2025 · PMID 39982184

RATIONALE: For staff in adult ICUs, providing family-centered care is an essential skill that affects important outcomes for both patients and families. The COVID-19 pandemic placed unprecedented strain on care of ICU families, and practices for family engagement and support are still adjusting. OBJECTIVES: To review updated evidence for family support in adult ICUs, provide clear recommendations, and spotlight optimal family-centered care practices post-pandemic. PANEL DESIGN: The multiprofessional guideline panel…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19 Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41739597

Immunocompromised individuals face elevated risks of severe COVID-19, yet vaccination guidance for these populations continues to evolve. To support evidence-based decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary panel to develop rapid guidelines on the use of US-licensed COVID-19 vaccines in adults and children with hematologic malignancies, primary immunodeficiency, autoimmune disease on immunosuppressive therapy, HIV with s…

Rank110.0
Clinical guideline or consensus statement

HRS/ACC scientific statement: Guiding principles on same-day discharge for intracardiac catheter ablation procedures.

Heart rhythm · 2025 · PMID 40272340

Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown. Access challenges (exacerbated during the COVID-19 public health emergency) and economic pressures have driven a shift in practi…

Rank110.0
Clinical guideline or consensus statement

2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 39471458

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019, developed by the Infectious Diseases Society of America. The guideline panel presents a recommendation on the use of the anti-severe acute respiratory syndrome coronavirus 2 neutralizing antibody pemivibart as pre-exposure prophylaxis. The recommendation is based on evidence derived from a systematic review and adheres to a standardized methodology for rating the certa…

Rank110.0
Clinical guideline or consensus statement

Pragmatic management of acute cough in children and adolescents: an updated position paper by the Italian Society of Pediatric Allergy and Immunology (SIAIP).

Allergologia et immunopathologia · 2026 · PMID 42115792

BACKGROUND: Cough is one of the most common and distressing symptoms in pediatric practice and represents a major cause of medical consultation, parental anxiety, and inappropriate medication use. Although most acute cough episodes are benign and self-limiting, they can significantly affect child's sleep, school performance, and quality of life. The COVID-19 pandemic and subsequent changes in infection patterns and immune responses have further highlighted the need to update the existing clinical guidance. OBJECTIV…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766598

Immunocompromised individuals experience disproportionately severe outcomes from respiratory syncytial virus (RSV) infection, yet direct evidence to guide vaccination in this population remains limited. To support clinical and shared decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary expert panel to develop rapid, evidence-based recommendations on RSV vaccination among immunocompromised adults and children. The panel conducted a…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19, Influenza, and RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766454

Respiratory viruses-including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19), respiratory syncytial virus (RSV), and influenza-pose significant risks to immunocompromised patients, who experience attenuated vaccine responses and higher morbidity. To address evolving vaccine recommendations for the 2025-2026 season, the Infectious Diseases Society of America (IDSA), in collaboration with the Vaccine Integrity Project (VIP) and partner organizations, developed rapid guidelines for US-license…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920902

This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents a new recommendation on the use of baricitinib vs. tocilizumab in hospitalized adults with severe or critical COVID-19. The panel has previously issued recommendations on baricitinib vs. no baricitinib and tocilizumab vs. no tocilizumab, but this new recommendation compares baricitinib to tocilizumab…

Rank107.0
Clinical guideline or consensus statement

Virtual integrated primary care teams: Recommendations for team-based care.

Families, systems & health : the journal of collaborative family healthcare · 2021 · PMID 34735210

INTRODUCTION: Integrated primary care teams are increasingly relying upon virtual care, including both telehealth and team members who are teleworking, due to the COVID-19 pandemic. This shift to virtual care can present challenges for the coordination and provision of team-based care in primary care. The current report uses extant literature on teams to provide recommendations to support integrated primary care teams, including behavioral health providers, in adapting to and sustaining virtual team-based care. MET…

Rank107.0
Clinical guideline or consensus statement

2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary.

Thrombosis and haemostasis · 2022 · PMID 34773920

The consensus of the Asia Pacific Heart Rhythm Society (APHRS) on stroke prevention in atrial fibrillation (AF) has been published in 2017 which provided useful clinical guidance for cardiologists, neurologists, geriatricians, and general practitioners in the Asia-Pacific region. In these years, many important new data regarding stroke prevention in AF were reported. The practice guidelines subcommittee members comprehensively reviewed updated information on stroke prevention in AF, and summarized them in this 2021…

Rank107.0
Clinical guideline or consensus statement

Public health issues and health rendezvous for migrants from conflict zones in Ukraine: A French practice guideline.

Infectious diseases now · 2022 · PMID 35483634

Given the number of people leaving the war zone in Ukraine and arriving in France, the French high council for public health (HCSP) has drawn up a number of recommendations. The experts have taken into account the vulnerability of migrant populations, which is exacerbated by (a) promiscuity that increases the risk of exposure to infectious agents; (b) the psychological consequences of conflict, family separation and exile; (c) prevalence in Ukraine of communicable diseases such as (possibly multi-resistant) tubercu…

Rank105.0
Systematic review or meta-analysis

Nebulized Heparin in Adults With Acute Respiratory Failure: A Meta-Analysis of Randomized Trials.

Critical care medicine · 2026 · PMID 42148826

OBJECTIVES: Dysregulated pulmonary coagulation and inflammation is a hallmark of respiratory failure in various etiologies. Excessive fibrin deposition contributes to alveolar collapse, impaired gas exchange, and progression to pulmonary fibrosis. Nebulized heparin can mitigate these coagulation and inflammation disturbances. Although several randomized controlled trials have explored its effects, results remain inconsistent and limited by small patient populations. We conducted a random-effects meta-analysis to ca…

Rank103.0
Clinical guideline or consensus statement

Standard headache and neuralgia treatments and SARS-CoV-2: opinion of the Spanish Society of Neurology's Headache Study Group.

Neurologia · 2020 · PMID 32896463

INTRODUCTION: In recent months, doubts have arisen among patients, general practitioners, and neurologists as to whether some drugs commonly used in patients with headaches and neuralgia may favour or complicate the disease caused by SARS-CoV-2. MATERIAL AND METHODS: We collected information on the opinions of scientific societies and medicines agencies (American, European, and Spanish) to clarify doubts regarding the use of drugs such as lisinopril, candesartan, ibuprofen, corticosteroids, carbamazepine, and monoc…

Rank100.0
Systematic review or meta-analysis

Can the Bergen Facebook Addiction Scale be adapted across contexts? Evidence from a COnsensus-based Standards for the selection of health Measurement INstruments systematic review.

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026 · PMID 41973776

OBJECTIVE: The Bergen Facebook Addiction Scale (BFAS) has served as a foundation for a series of adapted measures designed to assess social media-related behavioral addictions. Despite widespread application of these instruments, a systematic evaluation of their psychometric properties is lacking. This review aimed to evaluate the measurement properties of the BFAS and its adaptations using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology. METHOD: A systematic s…

Rank100.0
Systematic review or meta-analysis

Cost-Effectiveness of Virtual Emergency Care Models: Systematic Review.

JMIR mHealth and uHealth · 2026 · PMID 42555953

BACKGROUND: Virtual care technologies have rapidly expanded in emergency medicine, particularly following the COVID-19 pandemic. However, comprehensive economic evaluations of their cost-effectiveness remain fragmented across different clinical applications and health care settings, creating uncertainty for policymakers and health care administrators considering implementation. OBJECTIVE: This study aimed to systematically review and synthesize evidence on the cost-effectiveness of virtual emergency care models com…

Rank99.0
Systematic review or meta-analysis

Mathematical models for dengue fever epidemiology: A 10-year systematic review.

Physics of life reviews · 2022 · PMID 35219611

Mathematical models have a long history in epidemiological research, and as the COVID-19 pandemic progressed, research on mathematical modeling became imperative and very influential to understand the epidemiological dynamics of disease spreading. Mathematical models describing dengue fever epidemiological dynamics are found back from 1970. Dengue fever is a viral mosquito-borne infection caused by four antigenically related but distinct serotypes (DENV-1 to DENV-4). With 2.5 billion people at risk of acquiring the…

Rank98.5
Randomized controlled trial

Effectiveness of intensive community care services for adolescents with acute psychiatric emergencies: findings from a feasibility multi-centre, parallel-group, single-blinded RCT.

Health technology assessment (Winchester, England) · 2026 · PMID 42148829

BACKGROUND: Adolescents experiencing psychiatric emergencies often require intensive interventions to prevent hospitalisation and support their return to education, employment or training. Intensive Community Care Services aim to provide an alternative to inpatient care. AIMS: To evaluate the effectiveness of Intensive Community Care Services compared to treatment as usual in reducing the time to start or return to education, employment or training for young people with psychiatric emergencies. METHOD: A multicentr…

Rank98.0
Systematic review or meta-analysis

Laboratory-confirmed respiratory viral infection triggers for acute myocardial infarction and stroke: Systematic review protocol.

PloS one · 2024 · PMID 38985724

BACKGROUND: Cardiovascular disease contributes substantially to global mortality and morbidity. Respiratory tract infections, particularly influenza, may trigger an increase in the short-term risk of acute myocardial infarction (AMI) and stroke. Recent studies have also linked this risk to other respiratory viruses, including respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the pathogen-specific relative contributions, the strength of their associations, a…

Rank97.0
Systematic review or meta-analysis

Optimising partner notification outcomes for bacterial sexually transmitted infections: a deliberative process and consensus, United Kingdom, 2019.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022 · PMID 35057899

Partner notification (PN) is an essential element of sexually transmitted infection (STI) control. It enables identification, treatment and advice for sexual contacts who may benefit from additional preventive interventions such as HIV pre- and post-exposure prophylaxis. PN is most effective in reducing STI transmission when it reaches individuals who are most likely to have an STI and to engage in sexual behaviour that facilitates STI transmission, including having multiple and/or new sex partners. Outcomes of PN …

Rank97.0
Systematic review or meta-analysis

Educational Interventions to Support Primary Care Provider Performance of Diagnostic Skin Cancer Examinations: A Systematic Literature Review.

Journal of cancer education : the official journal of the American Association for Cancer Education · 2022 · PMID 35040018

To our knowledge, there is no available standardized educational curriculum designed to promote the incorporation of skin cancer examinations and procedures into general practice. To explore the contemporary training landscape, we conducted a systematic review of educational interventions designed to support skin cancer diagnostic examinations by primary care providers (PCPs). Our review uniquely encompasses all PCPs, including practicing physicians, residents, and advanced practice practitioners (APPs). The object…

Rank97.0
Systematic review or meta-analysis

Mask Use for Athletes: A Systematic Review of Safety and Performance Outcomes.

Sports health · 2022 · PMID 35855525

CONTEXT: With the current Centers for Disease Control and Prevention recommendations for mask use to minimize transmission of coronavirus 2019 (COVID-19) coupled with concern for future pandemics that would require mask wearing, providing data-driven guidance with respect to athletic performance is essential. OBJECTIVE: The purpose of this study was to perform a systematic review of existing literature on the use of face masks while exercising to assess the physiologic effects of face masks worn during athletic act…

Diagnosis And Screening189 records
Rank113.0
Systematic review or meta-analysis

Systematic review and meta-analysis of artificial intelligence models for diagnosing and subphenotyping ARDS in adults.

Heart & lung : the journal of critical care · 2026 · PMID 41037977

BACKGROUND: Artificial intelligence (AI) has emerged as a promising tool to improve the diagnosis and characterization of ARDS, including the identification of subphenotypes. OBJECTIVES: To evaluate the diagnostic performance and methodological quality of AI models for identifying ARDS and its subphenotypes in adults. METHODS: We conducted a systematic review and meta-analysis of 63 studies (n = 135,762) published between 2013 and 2024 in PubMed, Embase, and the Cochrane Library. Extracted outcomes included sensiti…

Rank109.8
Systematic review or meta-analysis

The impact of COVID-19 on young people's mental health, wellbeing and routine from a European perspective: A co-produced qualitative systematic review.

PloS one · 2024 · PMID 38507395

BACKGROUND: The impact of the Covid-19 pandemic on young people's (YP) mental health has been mixed. Systematic reviews to date have focused predominantly on quantitative studies and lacked involvement from YP with lived experience of mental health difficulties. Therefore, our primary aim was to conduct a qualitative systematic review to examine the perceived impact of the Covid-19 pandemic on YP's (aged 10-24) mental health and wellbeing across Europe. METHODS AND FINDINGS: We searched MEDLINE, PsycINFO, Embase, W…

Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank104.4
Systematic review or meta-analysis

Interventions to Support the Mental Health of Frontline Healthcare Workers During the COVID-19 Pandemic: A Systematic Review.

International journal of environmental research and public health · 2026 · PMID 42652397

The COVID-19 pandemic led to distress and an increased prevalence of psychopathology among front-line (FL) healthcare workers (HCWs). A synthesis of the available data on the effectiveness of MH interventions among FL HCWs is essential to inform an MH plan for FL HCWs in future pandemics. The objective of this systematic review is to examine interventions used to support the MH of FL HCWs during the COVID-19 pandemic. All studies published between 1 January 2020 and 1 March 2026 that reported on MH interventions am…

Rank100.2
Randomized controlled trial

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19.

Critical care explorations · 2026 · PMID 42329789

OBJECTIVES: Understanding the mechanistic impact of fostamatinib, a spleen tyrosine kinase inhibitor, in severe COVID-19 using biomarkers associated with disease severity is crucial for the development of host-directed therapeutics. We analyzed samples from a randomized clinical trial to investigate the impact of fostamatinib on multiple inflammatory biomarkers associated with COVID-19 disease severity. DESIGN: Secondary analyses of biomarkers from a randomized clinical trial. SETTING: Multicenter randomized clinic…

Rank100.0
Systematic review or meta-analysis

Sensitivity of gargle samples compared to swabs for SARS-CoV-2 detection with nucleic acid amplification testing: a systematic review and meta-analysis.

Virology journal · 2026 · PMID 42243943

BACKGROUND: Gargle sampling emerged as a novel method for diagnostic testing during the coronavirus disease 2019 (COVID-19) pandemic, yet uncertainty remained about its performance when compared with conventional sampling methods. OBJECTIVE: To evaluate the performance of self-collected gargle samples compared to traditional healthcare worker (HCW)-collected upper respiratory tract swabs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection with nucleic acid amplification testing (NAAT). METHOD…

Rank99.0
Systematic review or meta-analysis

Post-COVID Multisystem Inflammatory Syndrome in Children with Kawasaki-like Features: A Scoping Review of Middle Eastern Evidence.

Medicina (Kaunas, Lithuania) · 2026 · PMID 42654497

Background: Multisystem inflammatory syndrome in children (MIS-C) was recognized in 2020 as a post-infectious hyperinflammatory condition occurring 2-6 weeks after SARS-CoV-2 infection. While large studies from Europe and North America have described its clinical spectrum and outcomes, evidence from the Middle East remains limited. MIS-C shares features with Kawasaki disease (KD), including persistent fever, mucocutaneous manifestations, and cardiac involvement, but differs in age distribution, gastrointestinal inv…

Rank98.6
Systematic review or meta-analysis

Mechanical Power as a Predictor of Outcomes During Mechanical Ventilation in Coronavirus Disease 2019 (COVID-19): An Updated Systematic Review.

Journal of clinical medicine · 2026 · PMID 42652878

Background/Objectives: Mechanical power (MP) quantifies the energy delivered to the respiratory system during ventilation and serves as a promising marker for ventilator-induced lung injury (VILI). According to its original definition by Gattinoni, MP reflects the energy transferred from the ventilator to the respiratory system under conditions of deep sedation, passive breathing, neuromuscular blockade, and volume-controlled ventilation. Its role in coronavirus disease 2019 (COVID-19)-associated acute respiratory …

Rank98.6
Systematic review or meta-analysis

Systematic review of amino acid profiles among COVID-19 patients caused by SARS-CoV-2.

Journal of diabetes and metabolic disorders · 2026 · PMID 42491141

BACKGROUND: Emerging evidence highlights the critical role of amino acid metabolism in the pathogenesis and severity of COVID-19. This review included studies encompassing patients with varying degrees of disease severity, from mild to critical cases. METHODS: A systematic review following PRISMA guidelines was conducted, and study quality was appraised using the Newcastle-Ottawa tools to explore the relationship between amino acid profiles and clinical outcomes in COVID-19 patients. A comprehensive search of PubMe…

Rank98.5
Systematic review or meta-analysis

Virtual hospital services for adult patients: A scoping review.

International journal of medical informatics · 2026 · PMID 42556091

BACKGROUND AND OBJECTIVES: The COVID-19 pandemic expedited the use of virtual hospital services (VHS) and hybrid hospital-in-the-home (HITH) models. However, the current evidence base remains fragmented and heterogeneous in care model designs, terminology, and reported outcome measures. This scoping review maps the published literature on VHS models implemented or evaluated for adults aged 18 to 65 during and after the COVID-19 period. METHODS: Following the Joanna Briggs Institute (JBI) methodology and Preferred R…

Rank96.2
Randomized controlled trial

Center- vs Home-Based Cardiac Rehabilitation in Patients With Heart Failure: EXIT-HF Randomized Controlled Trial.

JACC. Heart failure · 2025 · PMID 39895436

BACKGROUND: Despite being an evidence-based intervention, the implementation of cardiac rehabilitation (CR) is often unsatisfactory, especially among patients with heart failure (HF). Home-based CR can serve as an alternative to improve accessibility for patients unable to participate in center-based programs. OBJECTIVES: The study sought to compare the clinical impact of center- vs home-based CR in HF patients. METHODS: Single-center, parallel group, noninferiority trial, enrolling HF patients irrespective of ejec…

Rank96.0
Systematic review or meta-analysis

Adolescent Suicide During the COVID-19 Pandemic: Bullying Dynamics, Risk Factors, and Prevention Strategies-A Systematic Review.

Healthcare (Basel, Switzerland) · 2026 · PMID 42651351

Objectives: To analyze adolescent suicide rates during the COVID-19 pandemic, examine the relationship between bullying, cyberbullying, and suicidal behavior, and identify evidence-based prevention strategies. Methods: A systematic review of 26 peer-reviewed articles (published between 2020 and 2025) was conducted across five databases. Studies were appraised for quality using STROBE and SRQR guidelines. Results: The pandemic significantly impacted adolescent mental health, increasing depression, anxiety, and suici…

Rank96.0
Systematic review or meta-analysisResult signal: harm

Home Visits as a Primary Health Care Strategy During COVID-19: Protocol for a Scoping Review.

JMIR research protocols · 2026 · PMID 42574707

BACKGROUND: Primary health care played a critical role during the COVID-19 pandemic by adapting care delivery to maintain essential services and reduce transmission risks. Home visits were used to monitor individuals in isolation, support vulnerable populations at increased risk, and sustain community-based care. However, their organization and operationalization varied across settings, and the available evidence remains fragmented. OBJECTIVE: This protocol outlines the methods for a scoping review that will system…

Rank96.0
Systematic review or meta-analysis

Applications of Artificial Intelligence in the Health Sector: A PRISMA-Based Systematic Review.

Healthcare (Basel, Switzerland) · 2026 · PMID 42651374

Background: The health sector is getting transformed with the usage of AI, be it diagnosis, treatment planning, disease prediction, and or health system management. Research in this field has picked up in the last few years, which was made possible with the emergence of machine learning, natural language processing and the increasing number of e-health records. Objectives: The study aims to investigate the current trends in the implementation of artificial intelligence (AI) applications in medical settings by inves…

Rank96.0
Systematic review or meta-analysis

Cytokine-Driven Hyperinflammation in Long COVID: Mechanisms, Biomarkers, Complement Dysregulation, and Emerging Immunotherapies-A Narrative Review.

Health science reports · 2026 · PMID 42657238

BACKGROUND AND AIMS: Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), is a multisystem condition characterized by persistent symptoms that continue beyond the acute phase of infection. Growing evidence indicates that sustained immune dysregulation involving cytokine-mediated inflammation, complement activation, endothelial dysfunction, thromboinflammation, and viral antigen persistence contributes to its pathogenesis. This narrative review summarizes current evidence on the mechanisms u…

Rank94.9
Randomized controlled trial

Determining the optimal frequency of SARS-CoV-2 regular asymptomatic testing: A randomized feasibility trial in a home care setting.

PloS one · 2024 · PMID 38959206

BACKGROUND: The SARS-CoV-2 pandemic presented a challenge for caregiving relatives in the home care setting. Caregivers can transmit SARS-CoV-2 to their relatives who are often at high risk for a severe course of COVID-19. Regular testing of asymptomatic caregivers for SARS-CoV-2 may reduce the risk of transmission. The optimal method and frequency of regular asymptomatic testing is unknown. We conducted a prospective, randomised trial to assess the feasibility, recruitment and acceptance of different testing frequ…

Rank92.0
Randomized controlled trialResult signal: null

The LTI-01-2001 phase 2a trial of intrapleural LTI-01 in patients with infected, non-draining pleural effusions.

Respiratory research · 2026 · PMID 42310706

BACKGROUND: Single chain urokinase (LTI-01) intrapleural enzymatic therapy (IET) was safe and promising in a phase 1 clinical trial to overcome failed drainage in patients with pleural infection. The LTI-01-2001 phase 2a trial was a randomized, double-blind, placebo-controlled, multi-center, dose-ranging study in hospitalized subjects with infected, non-draining pleural effusions. METHODS: LTI-01, in doses of 400,000, 800,000 or 1,200,000 Units, or placebo was administered intrapleurally once daily for up to 3 days…

Rank92.0
Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 · PMID 42420160

OBJECTIVES: The PRIME randomized trial demonstrated improved neonatal outcomes using biomarker-guided risk stratification to target interventions to pregnancies at higher risk of preterm birth (PTB). This subgroup analysis evaluated its effectiveness in nulliparous pregnancies, a population with higher baseline risk and limited obstetric history to inform risk assessment. METHODS: PRIME (NCT04301518) was a 19‑center randomized controlled trial evaluating a screen‑guided care strategy using the IGFBP4/SHBG biomarker…

Rank89.2
Randomized clinical study

Personalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial.

BMJ open · 2023 · PMID 37068906

INTRODUCTION: Although studies have examined the utility of clinical decision support tools in improving acute kidney injury (AKI) outcomes, no study has evaluated the effect of real-time, personalised AKI recommendations. This study aims to assess the impact of individualised AKI-specific recommendations delivered by trained clinicians and pharmacists immediately after AKI detection in hospitalised patients. METHODS AND ANALYSIS: KAT-AKI is a multicentre randomised investigator-blinded trial being conducted across…

Rank85.0
Randomized clinical study

Test-negative Designs with Various Reasons for Testing: Statistical Bias and Solution.

Epidemiology (Cambridge, Mass.) · 2026 · PMID 41474934

Test-negative designs (TNDs) are widely used for postmarket evaluation of vaccine effectiveness (VE), particularly in cases when randomized trials are not feasible. Unlike classical TNDs, which only include healthcare seekers with symptoms, recent TNDs have involved individuals with various reasons for testing, especially in an outbreak setting. While including these data can increase sample size and hence improve precision, concerns have been raised about whether they introduce bias into the current framework of T…

Rank85.0
Randomized clinical study

The role of telehealth in autism spectrum disorder management: a scoping review.

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina · 2026 · PMID 42592984

AIM: To map and summarise evidence on the role, benefits and challenges of telehealth in autism spectrum disorder (ASD) management, including assessment and intervention. METHODS: This scoping review searched PubMed and Scopus for English-language studies published from 2015 to 2025; the search was last updated on 14 April 2026. Nine studies met the eligibility criteria, comprising randomised controlled trials and observational, mixed-methods, descriptive, pilot, and qualitative studies. RESULTS: Available findings…

Rank78.4
Multicenter clinical study

Oropharyngeal swabs show higher bacterial loads than nasopharyngeal swabs for PCR detection of pertussis: a multicenter prospective study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42361964

OBJECTIVE: Pertussis remains a significant public health concern despite widespread vaccination, with a resurgence observed following the COVID-19 pandemic. The optimal sampling site for PCR-based detection of Bordetella pertussis remains uncertain. METHODS: We conducted a multicenter prospective study across five institutions in Japan between October 2024 and May 2025. A total of 475 patients presenting with cough were enrolled. Nasopharyngeal and oropharyngeal swabs were collected and analyzed using real-time pol…

Rank75.6
Multicenter clinical study

Longitudinal 1H and 129Xe Lung MRI in Patients With Post-COVID Residual Lung Abnormalities.

Journal of magnetic resonance imaging : JMRI · 2026 · PMID 42210667

BACKGROUND: It is unclear how lung function may recover in patients with residual lung abnormalities (RLAs) following COVID-19 pneumonia. PURPOSE: To evaluate lung function trends over time in patients with RLAs following hospitalization due to COVID-19. STUDY TYPE: Prospective, multicenter longitudinal cohort study. POPULATION: Twenty-four participants hospitalized due to COVID-19 with RLAs identified on CT ≥ 3 months postdischarge (median [IQR] age 69 (15) years; 3 female) underwent at least one MRI at 6 months (…

Rank73.6
Multicenter clinical study

COVID-19 in people with Cystic Fibrosis beyond the pre-omicron era: a prospective study with a specific focus on long COVID.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026 · PMID 40908194

BACKGROUND: The long-term clinical consequences of COVID-19 in cystic fibrosis (CF) remain largely unexplored. This study aimed to assess the incidence of long COVID in a large population of people with CF. METHODS: This prospective, multicentre study enrolled individuals with confirmed SARS-CoV-2 infection between July 2021 and October 2022. Data collected included clinical features prior to infection, symptoms during the acute phase, hospitalization and symptom persistence after 1 and 6 months. Long COVID was def…

Rank73.0
Multicenter clinical study

Functional alterations due to post-COVID-19 lung lesions - lessons from a multicenter V/Q SPECT/CT based registry.

European journal of nuclear medicine and molecular imaging · 2026 · PMID 41840047

PURPOSE: The COVID-19 pandemic has left many survivors with persistent respiratory symptoms such as dyspnea, chronic cough, and reduced exercise capacity. Fibrosis-like abnormalities on high-resolution CT are frequently reported in theses patient. This study aimed to describe the morphological pulmonary abnormalities identified on V/Q SPECT/CT after COVID-19 infection and to evaluate their functional consequences on regional ventilation and perfusion. We also sought to identify clinical predictors of abnormal V/Q S…

Evidence Syntheses124 records
Rank113.0
Systematic review or meta-analysis

Systematic review and meta-analysis of artificial intelligence models for diagnosing and subphenotyping ARDS in adults.

Heart & lung : the journal of critical care · 2026 · PMID 41037977

BACKGROUND: Artificial intelligence (AI) has emerged as a promising tool to improve the diagnosis and characterization of ARDS, including the identification of subphenotypes. OBJECTIVES: To evaluate the diagnostic performance and methodological quality of AI models for identifying ARDS and its subphenotypes in adults. METHODS: We conducted a systematic review and meta-analysis of 63 studies (n = 135,762) published between 2013 and 2024 in PubMed, Embase, and the Cochrane Library. Extracted outcomes included sensiti…

Rank111.5
Systematic review or meta-analysis

Relevance of Mediterranean diet as a nutritional strategy in diminishing COVID-19 risk: A systematic review.

PloS one · 2024 · PMID 39167591

BACKGROUND: Mediterranean Diet has been reported to possess immunomodulatory and anti-inflammatory properties. These properties are closely associated with the immunopathogenesis of COVID-19. OBJECTIVE: The present systematic review aimed to determine the association between Mediterranean Diet and COVID-19, COVID-19 symptoms, and COVID-19 severity. METHODS: The protocol for this systematic review was registered in International Prospective Register of Systematic Reviews (PROSPERO) with identification number CRD4202…

Rank110.0
Clinical guideline or consensus statement

HRS/ACC scientific statement: Guiding principles on same-day discharge for intracardiac catheter ablation procedures.

Heart rhythm · 2025 · PMID 40272340

Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown. Access challenges (exacerbated during the COVID-19 public health emergency) and economic pressures have driven a shift in practi…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19 Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41739597

Immunocompromised individuals face elevated risks of severe COVID-19, yet vaccination guidance for these populations continues to evolve. To support evidence-based decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary panel to develop rapid guidelines on the use of US-licensed COVID-19 vaccines in adults and children with hematologic malignancies, primary immunodeficiency, autoimmune disease on immunosuppressive therapy, HIV with s…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19, Influenza, and RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766454

Respiratory viruses-including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19), respiratory syncytial virus (RSV), and influenza-pose significant risks to immunocompromised patients, who experience attenuated vaccine responses and higher morbidity. To address evolving vaccine recommendations for the 2025-2026 season, the Infectious Diseases Society of America (IDSA), in collaboration with the Vaccine Integrity Project (VIP) and partner organizations, developed rapid guidelines for US-license…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766598

Immunocompromised individuals experience disproportionately severe outcomes from respiratory syncytial virus (RSV) infection, yet direct evidence to guide vaccination in this population remains limited. To support clinical and shared decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary expert panel to develop rapid, evidence-based recommendations on RSV vaccination among immunocompromised adults and children. The panel conducted a…

Rank110.0
Systematic review or meta-analysis

Differences in tuberculosis prevalence by sex in low- and middle-income countries over 1993-2025: A systematic review and meta-analysis.

PLoS medicine · 2026 · PMID 42172294

BACKGROUND: Global and national initiatives to combat tuberculosis (TB) have expanded over recent years. Despite this, the TB burden remains high in some population groups, with men recognized as having elevated TB risks. Summary measures of sex differences in TB prevalence were last estimated in 2016. Since then, many additional prevalence surveys have been conducted, including in the highest TB burden countries. We conducted a systematic review of sex-stratified TB prevalence survey data published over 1993-2025,…

Rank110.0
Clinical guideline or consensus statement

2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 39471458

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019, developed by the Infectious Diseases Society of America. The guideline panel presents a recommendation on the use of the anti-severe acute respiratory syndrome coronavirus 2 neutralizing antibody pemivibart as pre-exposure prophylaxis. The recommendation is based on evidence derived from a systematic review and adheres to a standardized methodology for rating the certa…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920902

This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and…

Rank110.0
Systematic review or meta-analysis

Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.

Journal of affective disorders · 2026 · PMID 42203050

BACKGROUND: Depression and anxiety constitute a global health crisis, with prevalence increasing by 27.6% during the COVID-19 pandemic. The 24-Hour Movement Guidelines, integrating physical activity, sedentary behavior, and sleep, have been linked to improved mental health, yet no meta-analysis has quantified these associations. METHODS: Following PRISMA guidelines, PubMed, Embase, Cochrane Library, and Web of Science were searched through January 1, 2026. Observational studies examining adherence to the 24-Hour Mo…

Rank110.0
Systematic review or meta-analysis

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Preventive medicine · 2026 · PMID 42303108

OBJECTIVE: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D) and a marker of delayed diagnosis, associated with significant morbidity, mortality, and healthcare costs. Global estimates of DKA at T1D onset remain inconsistent. METHODS: We conducted a systematic review and meta-analysis, searching PubMed (1996), Web of Science (1966), Embase (1947), and Scopus (1980), each from its inception to October 2025, without restrictions. Studies reporting DKA prevalence at diagnosis in i…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents a new recommendation on the use of baricitinib vs. tocilizumab in hospitalized adults with severe or critical COVID-19. The panel has previously issued recommendations on baricitinib vs. no baricitinib and tocilizumab vs. no tocilizumab, but this new recommendation compares baricitinib to tocilizumab…

Rank109.8
Systematic review or meta-analysis

The impact of COVID-19 on young people's mental health, wellbeing and routine from a European perspective: A co-produced qualitative systematic review.

PloS one · 2024 · PMID 38507395

BACKGROUND: The impact of the Covid-19 pandemic on young people's (YP) mental health has been mixed. Systematic reviews to date have focused predominantly on quantitative studies and lacked involvement from YP with lived experience of mental health difficulties. Therefore, our primary aim was to conduct a qualitative systematic review to examine the perceived impact of the Covid-19 pandemic on YP's (aged 10-24) mental health and wellbeing across Europe. METHODS AND FINDINGS: We searched MEDLINE, PsycINFO, Embase, W…

Rank108.8
Systematic review or meta-analysis

Prevalence and long-term outcomes of brain fog and cognitive impairment in individuals with long COVID: A systematic review.

Medicine · 2026 · PMID 42216347

BACKGROUND: Long COVID is increasingly recognized as a complex multisystem condition, with brain fog and cognitive impairment emerging as some of its manifestations. Despite growing literature, the pooled prevalence, subgroup differences, and underlying mechanisms remain incompletely understood. METHODS: We systematically reviewed 47 studies (2000-2025) encompassing over 25,000 patients to evaluate the prevalence of brain fog and cognitive impairment among long COVID populations. Data were extracted on study design…

Rank108.0
Systematic review or meta-analysisResult signal: null

Mental Health Symptom Changes by Sex or Gender Before and During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

JAMA network open · 2026 · PMID 42560673

IMPORTANCE: A previous systematic review reported that general mental health and anxiety symptoms, but not depression or stress, worsened more for females or women than for males or men from before to during the COVID-19 pandemic based on 12 studies published up to August 2021. OBJECTIVE: To update a systematic review on sex or gender differences in mental health symptom changes from before to during the COVID-19 pandemic. DATA SOURCES: Medline, PsycINFO, CINAHL, Embase, Web of Science, China National Knowledge Inf…

Rank107.9
Systematic review or meta-analysisResult signal: null

Telemedicine in Plastic Surgery: A Systematic Review and Meta-analysis of Utilization and Outcomes Pre- and Post-pandemic.

Aesthetic plastic surgery · 2026 · PMID 42045685

BACKGROUND: Telemedicine revolutionized healthcare post-COVID-19 by expanding virtual care across consultations, post-operative care, and inter-physician collaboration. However, its impact on adoption and effectiveness in plastic surgery remains underexplored. This study systematically compares pre- and post-pandemic telemedicine in plastic surgery, focusing on outcomes, accessibility, and patient satisfaction to inform best practices. METHODS: A systematic review was conducted using PubMed, Medline, and Web of Sci…

Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank106.1
Systematic review or meta-analysis

Effects of different exercise training modalities in post-COVID-19 individuals: a systematic review of randomized controlled trials.

Disability and rehabilitation · 2026 · PMID 41622853

PURPOSE: Although the COVID-19 pandemic has ended, long-term effects persist. Exercise training (ET) supports recovery, but evidence on optimal modalities is limited. This study evaluated the effects of different ET modalities in post-COVID-19 individuals. METHODS: A systematic search identified randomized controlled trials (RCTs) up to 23 September 2025, involving adults with COVID-19. Studies compared ≥4-week interventions-aerobic training, high-intensity interval training (HIIT), or combined training (aerobic pl…

Rank104.6
Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

OBJECTIVES: The reporting of patient-important outcomes (PIOs) in randomized controlled trials (RCTs) for COVID-19 varies widely, limiting their application in clinical decision-making. We evaluated how often PIOs were reported as primary outcomes in RCTs of COVID-19 treatments and identified trial characteristics associated with their reporting. STUDY DESIGN AND SETTING: This meta-epidemiological study analyzed primary outcome data from 102 RCTs evaluating COVID-19 treatments. RESULTS: Mortality outcomes were more…

Rank104.4
Systematic review or meta-analysisResult signal: harm

Viral Infections and Risk of Cardiovascular Disease: Systematic Review and Meta-Analysis.

Journal of the American Heart Association · 2025 · PMID 41160032

BACKGROUND: We conducted a systematic review and meta-analysis of studies examining the association of viral infections with the risk of cardiovascular disease, including coronary heart disease (CHD) and stroke. METHODS: MEDLINE, Embase, Web of Science, African-Wide Information, and the Cochrane Library database were searched from inception to July 2024. RESULTS: We included 155 studies. HIV infection was consistently associated with an elevated risk of CHD (pooled adjusted risk ratio [RR], 1.60 [95% CI, 1.38-1.85]…

Rank104.4
Systematic review or meta-analysis

Interventions to Support the Mental Health of Frontline Healthcare Workers During the COVID-19 Pandemic: A Systematic Review.

International journal of environmental research and public health · 2026 · PMID 42652397

The COVID-19 pandemic led to distress and an increased prevalence of psychopathology among front-line (FL) healthcare workers (HCWs). A synthesis of the available data on the effectiveness of MH interventions among FL HCWs is essential to inform an MH plan for FL HCWs in future pandemics. The objective of this systematic review is to examine interventions used to support the MH of FL HCWs during the COVID-19 pandemic. All studies published between 1 January 2020 and 1 March 2026 that reported on MH interventions am…

Rank104.2
Systematic review or meta-analysis

Factors that impact on healthcare workers' adherence with infection prevention and control (IPC) guidelines for COVID-19: a qualitative evidence synthesis.

The Cochrane database of systematic reviews · 2026 · PMID 42677895

BACKGROUND: The COVID-19 pandemic, declared in 2020, brought unprecedented challenges to our healthcare services in relation to the prevention and treatment of the disease. Additionally, preventing transmission within healthcare settings was critical. Infection Prevention and Control (IPC) guidelines are important for providing strategies on the use of personal protective equipment (PPE), the separation of patients with respiratory infections from others, and stricter cleaning routines. It is important to examine h…

Rank103.8
Systematic review or meta-analysis

Implications for future pandemics from a living systematic review and critical evaluation of observational studies of the effectiveness of COVID-19 vaccination against the Omicron variant.

Vaccine · 2026 · PMID 42594644

Reliable evidence on COVID-19 vaccine effectiveness during the period of Omicron variant predominance was essential to inform global vaccination strategies. Our living systematic review, commissioned by the World Health Organization (WHO), was established to provide an ongoing synthesis and critical appraisal of comparative observational studies evaluating the effectiveness of vaccines against COVID-19/SARS-CoV-2 infection caused by the Omicron variant. Weekly searches covering seven databases up to 31 December 202…

Rank103.8
Systematic review or meta-analysisResult signal: benefitCorrection flagged

Effects of Telehealth Interventions for People With Parkinson Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR mHealth and uHealth · 2026 · PMID 41604670

BACKGROUND: The global integration of telehealth into the management of Parkinson disease (PD) addresses critical gaps in health care access, especially for patients with limited mobility in underserved regions. Despite accelerated adoption during the COVID-19 pandemic, evidence regarding telehealth's multidimensional efficacy remains inconsistent. Previous meta-analyses reported conflicting outcomes for quality of life (QOL), motor symptoms, and neuropsychiatric comorbidities. OBJECTIVE: This study aimed to quanti…

Rank103.7
Systematic review or meta-analysis

The impact of COVID-19 on the peer relationships of adolescents around the world: A rapid systematic review.

Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025 · PMID 38682766

The main objective of this rapid systematic review was to examine how the COVID-19 pandemic impacted peer relationships for adolescents (10-25 years of age) around the globe. We focused on four indices of peer relationships: (1) loneliness, (2) social connectedness, (3) social support, and (4) social media use. In addition, we examined gender and age differences. Four databases (APA PsychInfo, PubMed, Scopus, and Web of Science) were searched for articles published from January 2020 to November 2022. A total of 96 …

Landmark Evidence109 records
Rank113.0
Systematic review or meta-analysis

Systematic review and meta-analysis of artificial intelligence models for diagnosing and subphenotyping ARDS in adults.

Heart & lung : the journal of critical care · 2026 · PMID 41037977

BACKGROUND: Artificial intelligence (AI) has emerged as a promising tool to improve the diagnosis and characterization of ARDS, including the identification of subphenotypes. OBJECTIVES: To evaluate the diagnostic performance and methodological quality of AI models for identifying ARDS and its subphenotypes in adults. METHODS: We conducted a systematic review and meta-analysis of 63 studies (n = 135,762) published between 2013 and 2024 in PubMed, Embase, and the Cochrane Library. Extracted outcomes included sensiti…

Rank110.0
Clinical guideline or consensus statement

HRS/ACC scientific statement: Guiding principles on same-day discharge for intracardiac catheter ablation procedures.

Heart rhythm · 2025 · PMID 40272340

Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown. Access challenges (exacerbated during the COVID-19 public health emergency) and economic pressures have driven a shift in practi…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents a new recommendation on the use of baricitinib vs. tocilizumab in hospitalized adults with severe or critical COVID-19. The panel has previously issued recommendations on baricitinib vs. no baricitinib and tocilizumab vs. no tocilizumab, but this new recommendation compares baricitinib to tocilizumab…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920902

This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and…

Rank108.8
Systematic review or meta-analysis

Prevalence and long-term outcomes of brain fog and cognitive impairment in individuals with long COVID: A systematic review.

Medicine · 2026 · PMID 42216347

BACKGROUND: Long COVID is increasingly recognized as a complex multisystem condition, with brain fog and cognitive impairment emerging as some of its manifestations. Despite growing literature, the pooled prevalence, subgroup differences, and underlying mechanisms remain incompletely understood. METHODS: We systematically reviewed 47 studies (2000-2025) encompassing over 25,000 patients to evaluate the prevalence of brain fog and cognitive impairment among long COVID populations. Data were extracted on study design…

Rank107.9
Systematic review or meta-analysis

Persistent symptoms among post-COVID-19 survivors: A systematic review and meta-analysis.

Journal of clinical nursing · 2024 · PMID 36426658

BACKGROUND: Single studies support the presence of several post-COVID-19 symptoms; however, there is no evidence for the synthesis of symptoms. OBJECTIVE: We attempt to provide an overview of the persistent symptoms that post-COVID-19 patients encounter, as well as the duration of these symptoms to help them plan their rehabilitation. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: A total of 16 studies involving 8756 patients post-COVID-19 were included. METHODS: The CINAHL, PubMed, EMBASE, Scopus, and …

Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank107.0
Systematic review or meta-analysis

Prevalence and risk of new-onset diabetes mellitus after COVID-19: a systematic review and meta-analysis.

Frontiers in endocrinology · 2023 · PMID 37732118

AIMS: After the acute phase of SARS-CoV-2 infection, the onset of glycemic impairment and diabetes have been reported. Nevertheless, the exact burden of glycemic impairment and diabetes after COVID-19 has not been clearly described. MATERIALS AND METHODS: Electronic search was run in Pubmed (MEDLINE), Web of Science, Scopus, and ClinicalTrial.org for reports published from database inception to September 2022. We included observational studies reporting quantitative data on diabetes prevalence or its onset in subje…

Rank107.0
Systematic review or meta-analysis

COVID-19 and healthcare workers: A systematic review and meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021 · PMID 33444754

BACKGROUND: The COVID-19 pandemic has focused attention on the challenges and risks faced by frontline healthcare workers (HCW). This study aimed to describe the clinical outcomes and risk factors for SARS-CoV-2 infection in HCW. METHODS: Three databases were surveyed and 328 articles were identified. Of these, 225 articles did not meet inclusion criteria; therefore, 97 full-text article were reviewed. Finally, after further revision, 30 articles were included in the systematic review and 28 were used for meta-anal…

Rank105.9
Systematic review or meta-analysis

Ischemic stroke associated with COVID-19: a systematic review and meta-analysis.

Journal of neurology · 2022 · PMID 34652503

BACKGROUND: Coronavirus disease 2019 (COVID-19), a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. Apart from respiratory complications, an increasing number of patients with ischemic stroke have been reporting. OBJECTIVE: This systematic review and meta-analysis aims to explore the characteristics of ischemic stroke after SARS-CoV-2 infection, and provides valuable reference materials for subsequent clinical treatment. MATERIALS AND…

Rank105.5
Systematic review or meta-analysis

Endometriosis and COVID-19: A Systematic Review and Meta-Analysis.

International journal of molecular sciences · 2022 · PMID 36361745

Endometriosis is defined as ectopic endometrial tissues dispersed outside the endometrium. This can cause disruption in hormonal and immunological processes, which may increase susceptibility to SARS-CoV-2 infection. Worsening of endometriosis symptoms may occur as a result of this infection. The aim of our review was to estimate the pooled prevalence of SARS-CoV-2 infection and the health impacts of the COVID-19 pandemic in endometriosis patients. We conducted a systematic review and meta-analysis. MEDLINE, Scienc…

Rank104.5
Systematic review or meta-analysis

A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat SARS-CoV-2 in Hospitalized Patients: Have the Guidelines Evolved With the Evidence?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40067859

BACKGROUND: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir, a broad-spectrum antiviral. Given the evolving nature of coronavirus disease 2019, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review with meta-analysis to summarize the effectiveness of remdesivir among hospitalize…

Rank104.4
Systematic review or meta-analysis

Long-term impact of SARS-CoV-2 infection on cardiorespiratory fitness: a meta-analysis.

Frontiers in public health · 2023 · PMID 37920575

BACKGROUND: Despite surviving Coronavirus disease 2019 (COVID-19), its long-term impact is of concern. Low cardiorespiratory fitness is a strong predictor of all-cause mortality, and likely affected by multisystem impairments following COVID-19 infection. Accumulating evidence has identified the impact of COVID-19 on cardiorespiratory fitness level. However, the findings have been controversial. Conclusive evidence is still needed. OBJECTIVES: This review aimed to systematically summarize and synthesize whether the…

Rank104.4
Systematic review or meta-analysis

Interventions to Support the Mental Health of Frontline Healthcare Workers During the COVID-19 Pandemic: A Systematic Review.

International journal of environmental research and public health · 2026 · PMID 42652397

The COVID-19 pandemic led to distress and an increased prevalence of psychopathology among front-line (FL) healthcare workers (HCWs). A synthesis of the available data on the effectiveness of MH interventions among FL HCWs is essential to inform an MH plan for FL HCWs in future pandemics. The objective of this systematic review is to examine interventions used to support the MH of FL HCWs during the COVID-19 pandemic. All studies published between 1 January 2020 and 1 March 2026 that reported on MH interventions am…

Rank103.6
Systematic review or meta-analysisResult signal: harm

Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis.

Journal of endocrinological investigation · 2022 · PMID 35527294

PURPOSE: The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated. METHODS: All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male …

Rank103.0
Systematic review or meta-analysis

Obesity in COVID-19: A Systematic Review and Meta-analysis.

Annals of the Academy of Medicine, Singapore · 2020 · PMID 33463658

OBJECTIVE: Obesity has been shown to be associated with adverse outcomes in viral infections such as influenza, but previous studies on coronavirus disease 2019 (COVID-19) had mixed results. The aim of this systematic review is to investigate the relationship between COVID-19 and obesity. METHODS: We performed a systematic review and meta-analysis. A literature search of MEDLINE, EMBASE, Scopus, Web of Science, CENTRAL, OpenGrey and preprint servers medRxiv and bioRxiv was performed, with no restriction on language…

Rank103.0
Systematic review or meta-analysis

Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe outcomes in adults: a systematic review and meta-analysis of European studies published up to 22 January 2024.

European respiratory review : an official journal of the European Respiratory Society · 2025 · PMID 39971395

BACKGROUND: Up-to-date evidence from European studies on long-term vaccine effectiveness (VE) of COVID-19 vaccines is lacking. This review aimed to evaluate effectiveness and durability of primary vaccine series and boosters in preventing infection and severe outcomes in the European population. METHODS: We conducted systematic searches of PubMed and Embase up to 22 January 2024. We included observational studies that evaluated VE against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or sev…

Rank102.6
Systematic review or meta-analysisResult signal: harm

COVID-19 associated oral and oropharyngeal microbiome: Systematic review and meta-analysis.

Periodontology 2000 · 2024 · PMID 37277934

Three years into the coronavirus disease 2019 (COVID-19) pandemic, there are still growing concerns with the emergence of different variants, unknown long- and short-term effects of the virus, and potential biological mechanisms underlying etiopathogenesis and increased risk for morbidity and mortality. The role of the microbiome in human physiology and the initiation and progression of several oral and systemic diseases have been actively studied in the past decade. With the proof of viral transmission, carriage, …

Rank102.6
Systematic review or meta-analysis

Risk factors for post-COVID-19 condition among previously hospitalized COVID-19 patients: a systematic review and meta-analysis.

Frontiers in public health · 2026 · PMID 42666214

BACKGROUND: Post-COVID-19 condition is a major source of long-term morbidity after SARS-CoV-2 infection. Patients hospitalized for COVID-19 may be at particularly high risk because hospitalization often reflects greater acute disease severity and comorbidity burden. However, evidence on risk factors in previously hospitalized populations remains inconsistent due to differences in outcome definitions, follow-up periods, and analytical approaches. This systematic review and meta-analysis aimed to identify risk factor…

Rank102.0
Systematic review or meta-analysis

Individual Participant Data Meta-Analysis (IPDMA) of long-term COVID-19 outcomes in a systematic review-informed, international, multidisciplinary database.

Health and social care delivery research · 2026 · PMID 42663308

BACKGROUND: Identifying and addressing long-term health and societal challenges after COVID-19 is a research priority. OBJECTIVES: To create an international, multidisciplinary COVID-19 database, and synthesise long-term outcomes, predictors and costs. DESIGN: Systematic identification of COVID-19 data sets and meta-analysis of individual participant data on long-term outcomes after COVID-19. SETTING: Contributed data were collected in clinical, community and research settings. INTERVENTIONS: Interventions from ori…

Rank101.9
Systematic review or meta-analysis

Orofacial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review.

International dental journal · 2022 · PMID 35367044

OBJECTIVES: Studies reviewing orofacial mycoses in coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection are sparse. Here we review the major oral and maxillofacial mycoses of COVID-19, the associated comorbidities, and the probable precipitating factors. METHODS: English-language manuscripts published between March 2020 and October 2021 were searched using PubMed, OVID, SCOPUS, and Web of Science databases, using appropriate keywords. RESULTS: We identified 30 art…

Rank101.4
Systematic review or meta-analysis

Prophylaxis against covid-19: living systematic review and network meta-analysis.

BMJ (Clinical research ed.) · 2021 · PMID 33903131

UPDATES: This is the second version (first update) of the living systematic review, replacing the previous version (available as a data supplement). When citing this paper please consider adding the version number and date of access for clarity. OBJECTIVE: To determine and compare the effects of drug prophylaxis on severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (covid-19). DESIGN: Living systematic review and network meta-analysis (NMA). DATA SOURCES: World…

Rank100.7
Systematic review or meta-analysis

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection.

Diabetes & metabolic syndrome · 2020 · PMID 32771919

BACKGROUND AND AIMS: The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing. The identification of risk factors for severe outcomes is important. Dyslipidemia has been shown as a long-known risk factor for cardiovascular disease. The aim of this study is to analyze the potential association between dyslipidemia and the severity of COVID-19 infection. METHODS: We systematically searched the PubMed database using specific keywords related to our aims until July 9th, 2020. …

Rank100.7
Randomized controlled trial

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine · 2026 · PMID 42398333

BACKGROUND: S-268024 is a recombinant protein vaccine developed as a COVID-19 booster. METHODS: This randomized, observer-blind, phase 3 study enrolled previously vaccinated Japanese adults without a history of SARS-CoV-2 infection. The noninferiority of the immunogenicity of the S-268024 booster vaccination versus NVX-CoV2373 was assessed. RESULTS: The immunogenicity population included 733 (S-268024 group: n = 368; NVX-CoV2373 group: n = 365) of 734 randomized participants. The geometric mean titer (GMT) ratio (9…

Rank100.6
Systematic review or meta-analysis

A systematic review and meta-analysis of the COVID-19 associated liver injury.

Annals of hepatology · 2020 · PMID 32882393

INTRODUCTION AND OBJECTIVES: The novel coronavirus disease 2019 (COVID-19) has affected more than 5 million people globally. Data on the prevalence and degree of COVID-19 associated liver injury among patients with COVID-19 remain limited. We conducted a systematic review and meta-analysis to assess the prevalence and degree of liver injury between patients with severe and non-severe COVID-19. METHODS: We performed a systematic search of three electronic databases (PubMed/MEDLINE, EMBASE and Cochrane Library), from…

Most Effective Evidence Supported Treatments120 records
Rank110.0
Clinical guideline or consensus statement

HRS/ACC scientific statement: Guiding principles on same-day discharge for intracardiac catheter ablation procedures.

Heart rhythm · 2025 · PMID 40272340

Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown. Access challenges (exacerbated during the COVID-19 public health emergency) and economic pressures have driven a shift in practi…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920902

This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and…

Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766598

Immunocompromised individuals experience disproportionately severe outcomes from respiratory syncytial virus (RSV) infection, yet direct evidence to guide vaccination in this population remains limited. To support clinical and shared decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary expert panel to develop rapid, evidence-based recommendations on RSV vaccination among immunocompromised adults and children. The panel conducted a…

Rank110.0
Clinical guideline or consensus statement

2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 39471458

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with coronavirus disease 2019, developed by the Infectious Diseases Society of America. The guideline panel presents a recommendation on the use of the anti-severe acute respiratory syndrome coronavirus 2 neutralizing antibody pemivibart as pre-exposure prophylaxis. The recommendation is based on evidence derived from a systematic review and adheres to a standardized methodology for rating the certa…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents a new recommendation on the use of baricitinib vs. tocilizumab in hospitalized adults with severe or critical COVID-19. The panel has previously issued recommendations on baricitinib vs. no baricitinib and tocilizumab vs. no tocilizumab, but this new recommendation compares baricitinib to tocilizumab…

Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank106.1
Systematic review or meta-analysis

Effects of different exercise training modalities in post-COVID-19 individuals: a systematic review of randomized controlled trials.

Disability and rehabilitation · 2026 · PMID 41622853

PURPOSE: Although the COVID-19 pandemic has ended, long-term effects persist. Exercise training (ET) supports recovery, but evidence on optimal modalities is limited. This study evaluated the effects of different ET modalities in post-COVID-19 individuals. METHODS: A systematic search identified randomized controlled trials (RCTs) up to 23 September 2025, involving adults with COVID-19. Studies compared ≥4-week interventions-aerobic training, high-intensity interval training (HIIT), or combined training (aerobic pl…

Rank104.6
Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

OBJECTIVES: The reporting of patient-important outcomes (PIOs) in randomized controlled trials (RCTs) for COVID-19 varies widely, limiting their application in clinical decision-making. We evaluated how often PIOs were reported as primary outcomes in RCTs of COVID-19 treatments and identified trial characteristics associated with their reporting. STUDY DESIGN AND SETTING: This meta-epidemiological study analyzed primary outcome data from 102 RCTs evaluating COVID-19 treatments. RESULTS: Mortality outcomes were more…

Rank104.4
Systematic review or meta-analysis

Interventions to Support the Mental Health of Frontline Healthcare Workers During the COVID-19 Pandemic: A Systematic Review.

International journal of environmental research and public health · 2026 · PMID 42652397

The COVID-19 pandemic led to distress and an increased prevalence of psychopathology among front-line (FL) healthcare workers (HCWs). A synthesis of the available data on the effectiveness of MH interventions among FL HCWs is essential to inform an MH plan for FL HCWs in future pandemics. The objective of this systematic review is to examine interventions used to support the MH of FL HCWs during the COVID-19 pandemic. All studies published between 1 January 2020 and 1 March 2026 that reported on MH interventions am…

Rank104.2
Systematic review or meta-analysis

Factors that impact on healthcare workers' adherence with infection prevention and control (IPC) guidelines for COVID-19: a qualitative evidence synthesis.

The Cochrane database of systematic reviews · 2026 · PMID 42677895

BACKGROUND: The COVID-19 pandemic, declared in 2020, brought unprecedented challenges to our healthcare services in relation to the prevention and treatment of the disease. Additionally, preventing transmission within healthcare settings was critical. Infection Prevention and Control (IPC) guidelines are important for providing strategies on the use of personal protective equipment (PPE), the separation of patients with respiratory infections from others, and stricter cleaning routines. It is important to examine h…

Rank103.8
Systematic review or meta-analysisResult signal: benefitCorrection flagged

Effects of Telehealth Interventions for People With Parkinson Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR mHealth and uHealth · 2026 · PMID 41604670

BACKGROUND: The global integration of telehealth into the management of Parkinson disease (PD) addresses critical gaps in health care access, especially for patients with limited mobility in underserved regions. Despite accelerated adoption during the COVID-19 pandemic, evidence regarding telehealth's multidimensional efficacy remains inconsistent. Previous meta-analyses reported conflicting outcomes for quality of life (QOL), motor symptoms, and neuropsychiatric comorbidities. OBJECTIVE: This study aimed to quanti…

Rank103.7
Systematic review or meta-analysis

Post-Infectious Cerebellitis: A Systematic Review of Aetiology, Clinical Presentation, Treatment, and Outcomes.

Cerebellum (London, England) · 2026 · PMID 42649322

Post-infectious cerebellitis is an immune-mediated cerebellar inflammatory syndrome that follows a preceding infection (or, rarely, vaccination) after a latent interval. It spans a spectrum from benign post-infectious/acute cerebellar ataxia (ACA) through more severe acute cerebellitis (AC) with leptomeningeal enhancement and mass effect, to rare, life-threatening acute fulminant cerebellitis (AFC) with hydrocephalus risk. Evidence is largely limited to individual case reports and small case series, and no prior re…

Rank102.6
Systematic review or meta-analysis

Evaluation of nirmatrelvir/ritonavir treatment for COVID-19 on health-related outcomes: a global economic value systematic literature review.

Journal of medical economics · 2026 · PMID 42406565

AIMS: Nirmatrelvir/ritonavir (NMV/r)i is an antiviral drug indicated for the treatment of patients with mild to moderate coronavirus disease 2019 (COVID-19) who are at high risk of progressing to severe disease. We performed an updated economic systematic literature review (eSLR) of NMV/r to build upon evidence reported in our previous eSLR and additionally examine the health-related outcomes associated with NMV/r and any potential effect of long COVID. METHODS: A systematic search of Embase, PubMed, Cochrane, and …

Rank102.6
Systematic review or meta-analysis

Risk factors for post-COVID-19 condition among previously hospitalized COVID-19 patients: a systematic review and meta-analysis.

Frontiers in public health · 2026 · PMID 42666214

BACKGROUND: Post-COVID-19 condition is a major source of long-term morbidity after SARS-CoV-2 infection. Patients hospitalized for COVID-19 may be at particularly high risk because hospitalization often reflects greater acute disease severity and comorbidity burden. However, evidence on risk factors in previously hospitalized populations remains inconsistent due to differences in outcome definitions, follow-up periods, and analytical approaches. This systematic review and meta-analysis aimed to identify risk factor…

Rank102.6
Systematic review or meta-analysis

A systematic review of observational studies of sodium-glucose cotransporter 2 inhibitors and COVID-19 outcomes: a methodological assessment.

Journal of clinical epidemiology · 2026 · PMID 42203176

OBJECTIVES: To conduct a systematic review of observational studies examining the association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and the risk of mortality and of hospitalization compared with the use of other antidiabetic medications in patients with type two diabetes and COVID-19, with a focus on the methodological quality. We also describe how such studies can be improved when addressing a public health emergency. STUDY DESIGN AND SETTING: We conducted a systematic review by searching Embas…

Rank102.0
Systematic review or meta-analysis

The growing burden of mental health and the role of digital technologies in the Global South: policies, cultural contexts, and community-based transformations-a systematic review of gray literature evidence.

Frontiers in public health · 2026 · PMID 42553331

BACKGROUND: Mental health conditions are among the fastest growing and most inequitably distributed global disease burdens. Structural determinants- poverty, conflict, climate change, and the COVID-19 pandemic compound a persistent mismatch between internationally developed policy frameworks and the cultural and infrastructural realities of populations in the Global South. OBJECTIVE: This systematic review identified, appraised, and synthesized gray literature evidence on (1) the growing mental health burden across…

Rank101.2
Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

BACKGROUND: The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we developed…

Rank101.1
Randomized controlled trial

Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial.

Nature medicine · 2026 · PMID 42521821

Combining multidisciplinary care plans into integrated care pathways (ICPs) is scalable, generalizable and effective for several long-term conditions, but not evaluated in Long COVID (LC). Our phase 3, cluster-randomized, multicenter clinical trial investigated the effectiveness of ICP interventions for LC. Recruitment of adults ≥18 years with LC was conducted in 6 National Health Service LC clinics in England with specialist ICPs. The intervention arms were (i) multi-organ magnetic resonance imaging (MRI; Coversca…

Rank100.7
Randomized controlled trial

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine · 2026 · PMID 42398333

BACKGROUND: S-268024 is a recombinant protein vaccine developed as a COVID-19 booster. METHODS: This randomized, observer-blind, phase 3 study enrolled previously vaccinated Japanese adults without a history of SARS-CoV-2 infection. The noninferiority of the immunogenicity of the S-268024 booster vaccination versus NVX-CoV2373 was assessed. RESULTS: The immunogenicity population included 733 (S-268024 group: n = 368; NVX-CoV2373 group: n = 365) of 734 randomized participants. The geometric mean titer (GMT) ratio (9…

Rank100.4
Systematic review or meta-analysisResult signal: harm

Bradyarrhythmia in Hospitalized Patients With SARS-CoV-2 Infection: A Systematic Scoping Review and Clustering Analyses.

Journal of the American Heart Association · 2026 · PMID 42500896

BACKGROUND: Among arrhythmias observed in SARS-CoV-2 infection, bradyarrhythmia poses the dilemma of urgent pacing. In this population, data on patients' characteristics and clinical outcomes are lacking. METHODS: A systematic literature search was conducted for bradyarrhythmia associated with COVID-19 from inception to December 2024 following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines; quality assessment was performed using the Joanna Briggs Institut…

Rank100.3
Randomized controlled trial

Identification of HIF1A as a therapeutic target during SARS-CoV-2-associated lung injury.

JCI insight · 2025 · PMID 40526427

Hypoxia-inducible factors (HIFs) promote lung protection and pathogen eradication during acute lung injury. We, therefore, tested the theory that pharmacologic stabilization of HIFs dampens lung injury during SARS-CoV-2 pneumonia. Initial studies in murine SARS-CoV-2 models showed improved outcomes after treatment with the FDA-approved HIF stabilizer vadadustat. Subsequent studies in genetic models implicated alveolus-expressed Hif1a in mediating lung protection. Therefore, we performed a randomized, double-blinded…

Rank100.2
Randomized controlled trial

Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.

Expert review of respiratory medicine · 2026 · PMID 42261259

BACKGROUND: Bovhyaluronidase azoximer (BA) has been reported to improve pulmonary function and exercise tolerance in patients with pulmonary sequelae of COVID-19. In this multicenter, randomized, double-blind, placebo-controlled study, we evaluated the effects of BA on patients with long-term (up to 12 months) pulmonary sequelae of COVID-19. METHODS: Patients (n = 392) were randomized 1:1 to receive BA or placebo every 5 days for 71 days. Percent predicted forced vital capacity (ppFVC), respiratory symptoms, and ex…

Rank100.0
Systematic review or meta-analysis

Factors influencing implementation of telemedicine in rural dementia care services in high-income countries: a scoping review.

BMC health services research · 2026 · PMID 42642758

BACKGROUND: Dementia care presents unique challenges in rural areas in high-income countries (HICs) due to limited access to specialised healthcare, fragmented services, and geographical isolation. Telemedicine has emerged as a promising solution, particularly accelerated by the coronavirus disease (COVID-19) pandemic. However, there remains a critical gap in understanding how telemedicine is operationalised within existing dementia care systems, particularly in rural contexts. The aim of this scoping review is to …

Rank100.0
Systematic review or meta-analysis

The Impact of Pulmonary Rehabilitation in Patients with Post-COVID-19 Syndrome: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42646577

BACKGROUND: Post-COVID-19 syndrome represents a global health problem, manifesting with persistent multiple organ symptoms, including respiratory ones. This review aimed to evaluate the efficacy of different pulmonary rehabilitation interventions in the management of the disease, including its particularities. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) statement and prospectively registered in the PROSPERO dat…

Rank100.0
Systematic review or meta-analysis

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review.

Journal of psychosomatic obstetrics and gynaecology · 2026 · PMID 42578412

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circumstances. OBJECTIVE: This systematic review aimed to provide an overview of psychological interventions for pregnant women during the COVID-19 pandemic and to evaluate their effectiveness in reducing distress and enhancing resilience. METHO…

New Research Last 24 Months411 records
Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920902

This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and…

Rank110.0
Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents a new recommendation on the use of baricitinib vs. tocilizumab in hospitalized adults with severe or critical COVID-19. The panel has previously issued recommendations on baricitinib vs. no baricitinib and tocilizumab vs. no tocilizumab, but this new recommendation compares baricitinib to tocilizumab…

Rank106.0
Systematic review or meta-analysis

Kids These Days! A Cross-Temporal Meta-Analysis of Changes in Emotional and Behavioral Problems of Population-Based Samples Over the Past Decades.

Clinical child and family psychology review · 2026 · PMID 42667567

There is a general belief that mental health problems are increasing in younger generations, though little objective comparisons exist. The current meta-analysis examines changes in subclinical mean-level overall symptom burden and shifts in specific domains among population-based samples of youth (1-18 years) globally over the last four decades. We search systematically in PubMed, Web of Science, Scopus, EBSCO and Google Scholar with pre-registered criteria. Included studies (k = 175, N = 418,528) use the standard…

Rank104.4
Systematic review or meta-analysis

Interventions to Support the Mental Health of Frontline Healthcare Workers During the COVID-19 Pandemic: A Systematic Review.

International journal of environmental research and public health · 2026 · PMID 42652397

The COVID-19 pandemic led to distress and an increased prevalence of psychopathology among front-line (FL) healthcare workers (HCWs). A synthesis of the available data on the effectiveness of MH interventions among FL HCWs is essential to inform an MH plan for FL HCWs in future pandemics. The objective of this systematic review is to examine interventions used to support the MH of FL HCWs during the COVID-19 pandemic. All studies published between 1 January 2020 and 1 March 2026 that reported on MH interventions am…

Rank102.6
Systematic review or meta-analysis

Risk factors for post-COVID-19 condition among previously hospitalized COVID-19 patients: a systematic review and meta-analysis.

Frontiers in public health · 2026 · PMID 42666214

BACKGROUND: Post-COVID-19 condition is a major source of long-term morbidity after SARS-CoV-2 infection. Patients hospitalized for COVID-19 may be at particularly high risk because hospitalization often reflects greater acute disease severity and comorbidity burden. However, evidence on risk factors in previously hospitalized populations remains inconsistent due to differences in outcome definitions, follow-up periods, and analytical approaches. This systematic review and meta-analysis aimed to identify risk factor…

Rank100.7
Randomized controlled trial

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine · 2026 · PMID 42398333

BACKGROUND: S-268024 is a recombinant protein vaccine developed as a COVID-19 booster. METHODS: This randomized, observer-blind, phase 3 study enrolled previously vaccinated Japanese adults without a history of SARS-CoV-2 infection. The noninferiority of the immunogenicity of the S-268024 booster vaccination versus NVX-CoV2373 was assessed. RESULTS: The immunogenicity population included 733 (S-268024 group: n = 368; NVX-CoV2373 group: n = 365) of 734 randomized participants. The geometric mean titer (GMT) ratio (9…

Rank100.0
Systematic review or meta-analysis

Systems thinking in public health interventions: a systematic review of barriers and facilitators.

BMC health services research · 2026 · PMID 42642760

BACKGROUND: Systems thinking has been promoted to address complex public health challenges involving fragmented systems, multi-sectoral governance, and interacting social determinants of health. However, its application in real-world public health interventions and the conditions influencing implementation remain understudied. This systematic review examines how systems thinking has been operationalized in public health interventions, identifies key facilitators and barriers to implementation, and interprets these …

Rank100.0
Systematic review or meta-analysis

Mare's Milk for Gut Microbiome Restoration and Immune Recovery After COVID-19 in Children and Pregnant Women: A Hypothesis-Generating Systematic Review.

Biomolecules · 2026 · PMID 42650868

BACKGROUND: Mare's milk has gained attention as a functional food due to its bioactive compounds and potential microbiome-modulating properties. This systematic review evaluated the evidence on its potential role in gut microbiome restoration and immune modulation following COVID-19, particularly in pediatric and maternal populations. METHODS: PubMed/MEDLINE, Scopus, Web of Science, and Embase were systematically searched for studies investigating mare's milk or koumiss and their effects on gut microbiota, immune r…

Rank100.0
Systematic review or meta-analysis

Factors influencing implementation of telemedicine in rural dementia care services in high-income countries: a scoping review.

BMC health services research · 2026 · PMID 42642758

BACKGROUND: Dementia care presents unique challenges in rural areas in high-income countries (HICs) due to limited access to specialised healthcare, fragmented services, and geographical isolation. Telemedicine has emerged as a promising solution, particularly accelerated by the coronavirus disease (COVID-19) pandemic. However, there remains a critical gap in understanding how telemedicine is operationalised within existing dementia care systems, particularly in rural contexts. The aim of this scoping review is to …

Rank100.0
Systematic review or meta-analysis

Stroke risk following BNT162b2 vaccination: a systematic review and meta-analysis of self-controlled case series studies.

Expert review of vaccines · 2026 · PMID 42661284

INTRODUCTION: Whether BNT162b2 (Pfizer-BioNTech) vaccination increases stroke risk remains a public health concern. This is the first meta-analysis to synthesize self-controlled case series (SCCS)-derived stroke risk estimates specifically for BNT162b2 vaccination. METHODS: PubMed and Embase were searched from inception through 9 May 2026, following PRISMA 2020 guidelines. Eight eligible SCCS studies were pooled using a random-effects model with restricted maximum likelihood (REML) estimation and the Knapp-Hartung …

Rank100.0
Systematic review or meta-analysis

The filtration performance of fabrics against particles of viral size: a systematic review.

BMC infectious diseases · 2026 · PMID 42642733

INTRODUCTION: Wearing a mask is part of the comprehensive strategy to suppress transmission of the SARS-CoV-2 virus and respiratory tract infections. Despite available COVID-19 vaccines, wearing a mask has remained one of the simplest and most effective ways. There was, however, little data available regarding the filtration of fabrics in masks against infectious aerosols or particles of viral size. This study reviewed the filtration performance of fabrics against virus-sized particles. METHODS: The systematic revi…

Rank100.0
Systematic review or meta-analysis

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review.

Journal of psychosomatic obstetrics and gynaecology · 2026 · PMID 42578412

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circumstances. OBJECTIVE: This systematic review aimed to provide an overview of psychological interventions for pregnant women during the COVID-19 pandemic and to evaluate their effectiveness in reducing distress and enhancing resilience. METHO…

Rank99.9
Randomized controlled trial

A process evaluation of a randomized clinical trial of selective decontamination of the digestive tract in ventilated adults admitted to intensive care: the SuDDICU PE study.

Trials · 2026 · PMID 42642777

BACKGROUND: The SuDDICU trial evaluated the effectiveness of selective digestive decontamination (SDD), a prophylactic antibiotic regimen comprising oral, gastric and intravenous (IV) components in ventilated adults admitted to intensive care. The trial recruited 9289 participants in 26 clusters across Australia and Canada. There was no difference in the primary outcome of in-hospital mortality, but a reduction in new positive blood cultures and antibiotic organisms. We conducted a concomitant process evaluation in…

Rank99.0
Systematic review or meta-analysis

Post-COVID Multisystem Inflammatory Syndrome in Children with Kawasaki-like Features: A Scoping Review of Middle Eastern Evidence.

Medicina (Kaunas, Lithuania) · 2026 · PMID 42654497

Background: Multisystem inflammatory syndrome in children (MIS-C) was recognized in 2020 as a post-infectious hyperinflammatory condition occurring 2-6 weeks after SARS-CoV-2 infection. While large studies from Europe and North America have described its clinical spectrum and outcomes, evidence from the Middle East remains limited. MIS-C shares features with Kawasaki disease (KD), including persistent fever, mucocutaneous manifestations, and cardiac involvement, but differs in age distribution, gastrointestinal inv…

Rank98.6
Systematic review or meta-analysis

Mechanical Power as a Predictor of Outcomes During Mechanical Ventilation in Coronavirus Disease 2019 (COVID-19): An Updated Systematic Review.

Journal of clinical medicine · 2026 · PMID 42652878

Background/Objectives: Mechanical power (MP) quantifies the energy delivered to the respiratory system during ventilation and serves as a promising marker for ventilator-induced lung injury (VILI). According to its original definition by Gattinoni, MP reflects the energy transferred from the ventilator to the respiratory system under conditions of deep sedation, passive breathing, neuromuscular blockade, and volume-controlled ventilation. Its role in coronavirus disease 2019 (COVID-19)-associated acute respiratory …

Rank98.6
Randomized controlled trial

Immunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

Vaccine · 2026 · PMID 42531981

A multicomponent vaccine targeting seasonal influenza and coronavirus disease 2019 (COVID-19) may reduce disease burden by providing simultaneous protection in a single injection. We report findings from Part 1 (Japan) of a phase 3, Asia-Pacific, randomized, observer-blind study evaluating immunogenicity, reactogenicity, and safety of mRNA-based multicomponent vaccine mRNA-1083, combining influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens. Participants aged ≥50 years were randomized…

Rank98.4
Randomized controlled trial

A pragmatic randomized controlled trial of self-directed online writing interventions for posttraumatic stress symptoms in a real-world digital setting.

European journal of psychotraumatology · 2026 · PMID 42635256

Background: Public health and other large-scale crises, such as the COVID-19 pandemic, have intensified the global mental health burden, creating unprecedented demand for accessible interventions for posttraumatic stress symptoms (PTSS).Objective: We evaluated the feasibility and effectiveness of two self-directed online writing interventions embedded within China's WeChat ecosystem during the COVID-19 pandemic through a pragmatic randomised controlled trial.Methods: Between December 2021 and August 2022, 1,526 adu…

Rank98.1
Randomized controlled trial

Montessori approaches counterbalance pandemic precautions in nursing homes: staff perspectives.

The Gerontologist · 2026 · PMID 41849432

BACKGROUND AND OBJECTIVES: We describe nursing home staff perspectives implementing Montessori approaches to person-centered care (MAP-VA) in Veterans Administration Community Living Centers (CLCs) during the coronavirus disease 2019 (COVID-19) pandemic We investigated. staff perspectives on implementing MAP-VA to promote resident autonomy, engagement, and connection in the context of pandemic-related safety precautions. RESEARCH DESIGN AND METHODS: We used longitudinal data from a stepped-wedge, randomized clinica…

Rank98.0
Systematic review or meta-analysis

The Association Between Job Stress and Intention to Leave in Healthcare Institutions: A Systematic Review and Meta-Analysis.

Healthcare (Basel, Switzerland) · 2026 · PMID 42651310

Background: Job stress is a pervasive issue in modern workplaces and is associated with numerous adverse outcomes, including employees' turnover intention when stress levels are high. Objective: This study aimed to examine the association between job stress and turnover intention among employees working in healthcare institutions through meta-analysis. Methods: A systematic literature review and meta-analysis were performed following PRISMA guidelines. The study was registered in the International Prospective Regis…

Rank97.9
Randomized controlled trial

Body mass index and baricitinib treatment effect in hospitalized adults with COVID-19: A secondary analysis of ACTT-2.

Heart & lung : the journal of critical care · 2026 · PMID 42247829

BACKGROUND: Obesity alters inflammatory signaling in critical illness. Whether body weight modifies response to targeted immunomodulatory therapy remains unknown. OBJECTIVES: To assess whether body mass index (BMI) and metabolic phenotypes modify the treatment effect of baricitinib in hospitalized adults with COVID-19. METHODS: We conducted a secondary analysis of the Adaptive COVID-19 Treatment Trial 2, which randomized participants to baricitinib plus remdesivir versus placebo plus remdesivir between May and July…

Rank97.9
Randomized controlled trial

Real-world effectiveness and safety of protein-based and mRNA COVID-19 vaccines (BEEHIVE trial).

Vaccine · 2026 · PMID 42486052

BACKGROUND: Real-world vaccine effectiveness (VE) and relative VE (rVE) data of protein-based and mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infections inform policy recommendations and reinforce public confidence. The study aim was to assess the safety and VE of the 2023-2024 protein-based and mRNA COVID-19 vaccines (XBB.1.5) in a real-world setting. METHODS: The single-site, pragmatic BEEHIVE clinical trial was conducted among participants aged ≥18 years from the Salt Lake City, Utah, area, who had pre…

Rank97.9
Randomized controlled trial

Immunogenicity and reactogenicity of fractional vs. full booster doses of COVID-19 vaccines: A non-inferiority, randomized, double-blind, phase IV clinical trial in Pakistan.

Vaccine · 2026 · PMID 42480193

BACKGROUND: We evaluated the immunogenicity and safety of fractional doses of SARS-CoV-2 booster vaccines compared to full doses in adults aged 18-60 primed with full series of Sinovac, AZD1222, or Natural Infection in Sindh, Pakistan. METHODS: This observer-blind, randomized phase IV non-inferiority trial (Feb 2023-Jan 2024) evaluated one-third, half, or full doses of BNT162b2, or full-dose Sinovac, in 10 arms based on primary vaccination. Participants were followed for 6 months with blood samples and safety asses…

Rank97.5
Randomized controlled trial

Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study).

Gut microbes · 2026 · PMID 42520140

BACKGROUND: Although COVID-19 vaccination has reduced morbidity and mortality, adults aged 65 y old and older are at high risk of complications from COVID-19. The evidence suggests that probiotics may enhance immune responses when co-administered with influenza vaccination. However, few studies have evaluated the potential benefit of probiotic supplementation in this context in this high-risk population. MATERIAL: This study was a randomized controlled trial recruiting adults between 65 and 89 y of age living in Qu…

Rank97.5
Randomized controlled trial

Sustained mental health outcomes from the youth readiness intervention: A four-year effectiveness follow-up of a hybrid type II trial in Sierra Leone.

Journal of child psychology and psychiatry, and allied disciplines · 2026 · PMID 42046391

BACKGROUND: Strategies to expand access to care and sustain evidence-based mental health interventions (EBIs) must be tested within novel delivery platforms to extend the reach of services in fragile and conflict-affected settings. Integration into broader development programs may help maintain long-term effects. This study presents a four-year follow-up of a previously conducted Hybrid Type II implementation-effectiveness cluster-randomized trial (CRT) of the Youth Readiness Intervention (YRI)-an EBI drawing on co…

Rank97.3
Randomized controlled trial

Safety and immunogenicity of an mRNA COVID-19 vaccine administered to adults: A phase 2, randomized, active-controlled trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42647564

We conducted a phase 2, randomized, active-controlled, observer-blind study (NCT05960097) among healthy adults ≥18 y of age who completed a primary COVID-19 mRNA vaccination series, with or without a booster, ≥3 months earlier. Participants were randomized (1:1:1:1:1) to either receive an investigational bivalent mRNA COVID-19 vaccine encoding ancestral D614G and Omicron BA.4-5 spike proteins (CV0701 mRNA vaccine) at one of three dose levels, an investigational monovalent mRNA COVID-19 vaccine encoding the Omicron …

Preclinical Research84 records
Rank100.0
Systematic review or meta-analysis

The filtration performance of fabrics against particles of viral size: a systematic review.

BMC infectious diseases · 2026 · PMID 42642733

INTRODUCTION: Wearing a mask is part of the comprehensive strategy to suppress transmission of the SARS-CoV-2 virus and respiratory tract infections. Despite available COVID-19 vaccines, wearing a mask has remained one of the simplest and most effective ways. There was, however, little data available regarding the filtration of fabrics in masks against infectious aerosols or particles of viral size. This study reviewed the filtration performance of fabrics against virus-sized particles. METHODS: The systematic revi…

Rank100.0
Systematic review or meta-analysis

Prevalence and risk factors of bovine tuberculosis in dairy cattle, 2020-2025: A systematic review and meta-analysis of available literature.

Preventive veterinary medicine · 2026 · PMID 42176585

BACKGROUND: Bovine tuberculosis (bTB) is a zoonotic disease caused by members of the Mycobacterium tuberculosis complex (MTBC), with Mycobacterium bovis being the primary agent responsible for infections in cattle, posing a significant threat to the global dairy industry. Although the COVID-19 pandemic during the 2020-2025 period may have disrupted its epidemiology, a comprehensive global meta-analysis of bTB prevalence and risk factors in dairy cattle for this period is currently lacking. METHODS: We conducted an …

Rank96.0
Systematic review or meta-analysis

Reliability of accelerated confirmatory trials during the COVID-19 pandemic: the consequences of low pre-trial plausibility.

Journal of clinical epidemiology · 2026 · PMID 42600710

OBJECTIVE: The reliability of confirmatory clinical trials (i.e. the post-trial probability) depends on the pre-trial probability. During the COVID-19 pandemic, many early COVID-19 confirmatory trials were launched despite limited phase II evidence and weak mechanistic or preclinical support. Whether this accelerated development strategy reduced the reliability of therapeutic evidence remains uncertain. STUDY DESIGN AND SETTING: Overall empirical pre-trial plausibility was estimated at the trial level as the propor…

Rank88.0
Randomized clinical study

Cannabis and Cannabinoids: The Medical Potential of Cannabidiol in Mental and Neurological Disorders.

Pharmaceuticals (Basel, Switzerland) · 2026 · PMID 42653735

Background/Objectives: Mental and neurological disorders contribute substantially to the global burden of disease, affecting people of all ages and backgrounds. As their prevalence increases with age, their overall impact is expected to grow in the coming decades. Although psychological and pharmacological treatments are available, many patients fail to achieve satisfactory outcomes, underscoring the need for improved therapeutic strategies. Cannabis sativa L. has been used for medicinal purposes for centuries, and…

Rank85.0
Randomized clinical studyResult signal: null

The evolving role of heparin in sepsis: therapeutic potential in the age of immunothrombosis.

Journal of thrombosis and haemostasis : JTH · 2026 · PMID 42362025

Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection and remains a leading cause of global morbidity and mortality. Despite decades of research, most biologically targeted therapies have failed to improve survival, highlighting the need for new treatment strategies that address the complex pathophysiology of sepsis. A defining feature of sepsis is immunothrombosis, characterized by widespread activation of inflammation and coagulation, endothelial injury, platelet activation, an…

Rank82.2
Multicenter clinical study

Real-world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study.

Signal transduction and targeted therapy · 2025 · PMID 39819859

Azvudine and nirmatrelvir-ritonavir (Paxlovid) were widely used to treat patients with COVID-19 in China during the Omicron wave. However, the efficacy and safety of azvudine versus Paxlovid are poorly established. This study included 40,876 hospitalized patients with COVID-19 from eleven hospitals in Henan and Xinjiang Provinces, China. Clinical outcomes were compared between the two drugs via Kaplan-Meier analysis and Cox regression models. Additionally, in vitro and in vivo experiments were used to evaluate the …

Rank45.0
Other PubMed-indexed publication

Lineage-specific pulmonary transcriptome landscape of coronavirus infection unveils universal immunotherapy for viral pneumonia.

Molecular therapy : the journal of the American Society of Gene Therapy · 2026 · PMID 42576386

Over the past decades, respiratory virus infections have led to millions of cases of critical illness and deaths in humans. However, the high mutation rate of respiratory viruses greatly reduces the effectiveness of virus-target countermeasures such as vaccines and antibodies, necessitating the development of host-target immunotherapies. In a hamster model of SARS-CoV-2 infection, we observed diverse disease outcomes, delineated the variant-specific lung transcriptome landscape, and demonstrated that a rational com…

Rank45.0
Other PubMed-indexed publication

Price volatility and GHG emissions analysis on smaller cattle herds typical for the pre-Alpine region, the example of Slovenia.

PloS one · 2024 · PMID 39576838

Agricultural input and output prices have become extremely volatile in recent years and the global meat industry faces sustainability challenges related to climate change, resource competition, environmental regulations, animal welfare concerns, consumer preferences and industry policies. Additionally, the economic situation of cattle fattening farms has been significantly impacted by two major shocks: the COVID-19 pandemic and the onset of the war in Ukraine. This has led to a growing demand for microsimulation to…

Rank45.0
Other PubMed-indexed publication

SARS-CoV-2 nucleocapsid protein drives pulmonary injury by enhancing GRP75-dependent ER-mitochondria tethering and reprogramming of alveolar macrophages.

Life sciences · 2026 · PMID 42570816

AIMS: To determine whether the SARS-CoV-2 nucleocapsid (N) protein promotes lung injury by augmenting GRP75-dependent endoplasmic reticulum (ER)-mitochondria tethering and reprogramming alveolar macrophages (AMϕs). MATERIALS AND METHODS: MAMs, ER, and mitochondria were isolated from mouse lungs. Bone marrow-derived and RAW264.7 macrophages were stimulated with recombinant N protein ± lentiviral GRP75 knockdown. ER-mitochondria interactions, tethering complex formation, mitochondrial Ca2+ dynamics, and function were…

Rank45.0
Other PubMed-indexed publication

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice.

eLife · 2026 · PMID 42059889

mRNA vaccines emerged as a leading vaccine technology during the COVID-19 pandemic. However, their sustained protective efficacies were limited by relatively short-lived antibody responses and the emergence of SARS-CoV-2 variants, necessitating frequent and variant-updated boosters. We recently developed the ESCRT- and ALIX-binding region (EABR) mRNA vaccine platform, which encodes engineered immunogens that induce budding of enveloped virus-like particles (eVLPs) from the plasma membrane, thereby resulting in pres…

Rank45.0
Other PubMed-indexed publication

Macroporous hydrogel-based mRNA cancer vaccine for in situ recruitment and modulation of dendritic cells.

Acta biomaterialia · 2025 · PMID 40774368

mRNA-based vaccines have demonstrated tremendous success in the era of covid-19, but their full potential for cancer treatment awaits to be realized. To address the low efficiency of conventional mRNA vaccines to encounter and become taken up by dendritic cells in the body, here we report a macroporous hydrogel-based mRNA vaccine that enables in situ recruitment and modulation of dendritic cells. Upon subcutaneous injection of macroporous hydrogels loaded with chemokines and neoantigen-encoding mRNA lipoplexes, hig…

Rank45.0
Other PubMed-indexed publication

Organoid-based evaluation of SA55 and Pemivibart against evolving SARS-CoV-2 variants.

Emerging microbes & infections · 2026 · PMID 42545256

Pemivibart, a class 1/4 monoclonal antibody (mAb), is currently the only FDA-authorized SARS-CoV-2 mAb under an Emergency Use Authorization (EUA) in clinical use. The emergence of subvariants, including KP.3.1.1 and XFG, raises concerns about antibody efficacy. SA55, a fully human class 1/4 mAb, is currently under clinical trial, including a nasal spray formulation. Using the well-validated organoid-based neutralization assays, we compared the potency and breadth of Pemivibart and SA55. Our results demonstrated a s…

Rank45.0
Other PubMed-indexed publication

Chronic neuroinflammation after acute SARS-Cov-2 infection induces retinal damage in the hACE2 transgenic mouse model.

Journal of neuroimmunology · 2026 · PMID 42335857

BACKGROUND: A number of patients infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) show a wide range of systemic complications. Previous studies have shown that acute SARS-CoV-2 infection can be accompanied by conjunctivitis, various forms of ocular inflammation and retinal vasculitis. However, long-term changes of the retina after SARS-CoV-2 infection have not been examined. In this study, we investigated neuroinflammation in the retina and optic nerve. METHODS: hACE2 Tg mice, serologicall…

Rank45.0
Other PubMed-indexed publication

Detection of ionisable lipids in equine plasma by supported liquid extraction and liquid chromatography-high-resolution tandem mass spectrometry for doping control of mRNA agents.

Journal of chromatography. A · 2026 · PMID 42430841

Messenger ribonucleic acid (mRNA) has emerged as a new class of therapeutic agent with unprecedented potential. In particular, the lipid nanoparticle (LNP)-mRNA formulations enabled safe and effective delivery of mRNA in vivo, leading to the success of mRNA vaccines during the COVID-19 pandemic. To control the potential misuse of LNP-mRNA agents in equine sports, a simple and sensitive method has been developed for the detection of ionisable lipids in equine plasma using supported liquid extraction (SLE) followed b…

Rank45.0
Other PubMed-indexed publication

What happened after the epidemic? Equine influenza surveillance sheds light on sources and seasonal risk in the United Kingdom.

Equine veterinary journal · 2026 · PMID 41787702

BACKGROUND: The epidemiology of equine influenza (EI) in the United Kingdom has not been systematically described since the 2019 epidemic. OBJECTIVES: To summarise UK EI surveillance (2020-2024), quantify outbreak seasonality and assess movement-related sources. STUDY DESIGN: Retrospective observational analysis of national surveillance and horse importation data. METHODS: Epidemiological data for laboratory-confirmed EI cases in the United Kingdom were collated. Outbreaks (EI-infected premises) were defined as one…

Rank45.0
Other PubMed-indexed publication

mRNA-LNP hepatitis C vaccine encoding p7 elicits improved humoral immunogenicity.

Vaccine · 2026 · PMID 42486050

Nucleoside-modified messenger RNA lipid nanoparticle (mRNA-LNP) vaccines have had a tremendous impact on vaccine development against infectious pathogens, particularly since the onset of the COVID-19 pandemic. The platform is an effective stimulator of humoral and cellular immune responses due to unique features of the mRNA and LNP components. We sought to optimize the performance of the mRNA-LNP platform against a specific viral target, developing a vaccine against Hepatitis C virus (HCV) that would improve HCV-li…

Rank45.0
Other PubMed-indexed publication

Eosinophil-associated intestinal immune responses following SARS-CoV-2 infection in K18-hACE2 mice.

PloS one · 2026 · PMID 42585251

BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is frequently associated with gastrointestinal manifestations; however, intestinal immune responses following SARS-CoV-2 infection remain incompletely understood. This study aimed to characterize eosinophil-associated intestinal immune responses in SARS-CoV-2-infected K18-hACE2 transgenic mice. METHODS: Small intestinal tissues from infected mice were analyzed using cytokine and chemokine PCR arr…

Rank45.0
Other PubMed-indexed publication

Molecular surveillance of coronaviruses in livestock in northern Vietnam.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2026 · PMID 42424669

Coronavirus (CoV) infections continue to pose a significant challenge to global public health and food security. The COVID-19 pandemic has underscored the importance of One Health approaches and improved surveillance systems. This is due to the considerable potential of CoVs to infect a broad spectrum of hosts and cause respiratory diseases. The present study investigated CoVs circulating in livestock in northern Vietnam using molecular detection and phylogenetic analysis. A total of 412 samples collected from live…

Rank45.0
Other PubMed-indexed publication

Simplified Inhouse Nanoweb Membrane Enrichment Coupled Viral Whole Genome Shotgun Metagenomics Approach for Waste Water Surveillance.

Food and environmental virology · 2026 · PMID 42584818

Wastewater/sewage represents a highly complex environmental matrix and harbors various viruses including viruses of epidemic and pandemic potential like Influenza A and, SARS-CoV-2. The limitations of available methods for sample concentration are cost, efficiency and time. NGS- metagenomics offer sample to virus genomic characterization for even non-cultivable viruses at highest resolution. In this study, we have collected samples from sewage treatment plants located in Gwalior region of Central India (December 20…

Rank45.0
Other PubMed-indexed publication

Chronic toxicity of pandemic-driven chloroquine diphosphate use in aquatic ecosystems: zebrafish (Danio rerio) as a model species.

Ecotoxicology (London, England) · 2026 · PMID 42622704

Chloroquine diphosphate (CQD) is used for treating systemic and endemic diseases, with increased consumption during the COVID-19 pandemic. Its widespread use has led to increased detection in aquatic environments, where previous studies have reported oxidative stress and physiological disturbances in aquatic organisms. This study evaluated the chronic effects of CQD on zebrafish (Danio rerio) exposed for 21 days to environmentally relevant concentrations (0.6, 1.8, 5.4, 16.2, and 48.6 µg/L). Biomarkers related to m…

Rank45.0
Other PubMed-indexed publication

T cell-associated immunity induced by heterologous recombinant BCG and purified protein vaccination confers cross-variant protection against SARS-CoV-2.

Human vaccines & immunotherapeutics · 2026 · PMID 42423335

Previously, we have developed a recombinant BCG-based vaccine (rBCG) expressing a chimeric protein with spike and nucleocapsid epitopes (rChimera) to combine BCG's innate immune training capacity with SARS-CoV-2-specific adaptive immune responses. The heterologous prime-boost rBCG/rChimera+Alum regimen induced strong humoral and cellular immunity, conferring protection against the ancestral Wuhan strain in K18-hACE2 mice. Here, we used knockout mice lacking functional B cells, CD4+, or CD8+ T lymphocytes expressing…

Rank45.0
Other PubMed-indexed publication

Pleiotropic effects of direct oral anticoagulants on the coagulation-inflammation-endothelium axis: A phenotype-stratified narrative review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026 · PMID 42462434

AIMS: Direct oral anticoagulants (DOACs) - dabigatran (a thrombin inhibitor) and rivaroxaban, apixaban, and edoxaban (factor Xa [FXa] inhibitors) - modify oxidative stress, endothelial inflammation, and barrier integrity beyond anticoagulation. We ask whether this reflects distinct pharmacology or silencing of proteases at protease-activated receptors (PARs), and propose a three-condition framework for when it becomes clinically measurable. METHODS: Narrative review (PubMed, Scopus, Web of Science; primary search 2…

Rank45.0
Other PubMed-indexed publication

Functional neutralizing and bactericidal antibody responses induced by dual-target immunization with SARS-CoV-2 RBD and Neisseria meningitidis antigens in mice.

Vaccine · 2026 · PMID 42585813

Vaccination can elicit functional antibodies to reduce the burden of infectious diseases, such as neutralizing antibodies (nAbs) to control COVID-19, and bactericidal antibodies to prevent meningococcal disease. BALB/c mice were immunized with the receptor binding domain (RBD) from SARS-CoV-2, mixed with outer membrane vesicles (OMVs) from N. meningitidis and Aluminum hydroxide, resulting in a simultaneous immune response to SARS-CoV-2 and meningococci, and IgG transference to the offspring, as published in a previ…

Rank45.0
Other PubMed-indexed publication

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

Biomaterials · 2027 · PMID 42424692

Messenger RNA (mRNA) vaccines require efficient delivery systems to reach antigen-presenting cells (APCs). Lipid nanoparticles (LNPs) are a standard delivery carrier. However, LNPs often accumulate in the liver and exhibit transient protein expression. These limitations can restrict their safety and immunogenic potential. Here, we developed a modular, peptide-based nanocomplex to overcome the current limitations. The system comprises three functional peptides: an RNA-binding peptide (RBP) for condensation, l-polygl…

Rank45.0
Other PubMed-indexed publication

Structure-guided optimization of N-(5-((2-oxopropyl) thio)-1,3,4-thiadiazol-2-yl) propionamide frameworks as potent SARS-CoV-2 Mpro inhibitor for treating coronavirus disease.

Bioorganic chemistry · 2026 · PMID 42314596

The global outbreak of COVID-19, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in over 774 million cases and 7 million deaths worldwide since January 2020. Although widespread vaccination has been instrumental in reducing transmission and disease severity, there is a persistent and urgent need for effective treatments. This has made the virus's main protease (Mpro), a key enzyme in its replication cycle, a leading target for drug development. In the current research work, a sc…

Promising Experimental Therapies66 records
Rank100.0
Systematic review or meta-analysis

Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review.

EBioMedicine · 2026 · PMID 42520549

BACKGROUND: The COVID-19 pandemic created a unique situation in which researchers repurposed human models of varying complexity to investigate SARS-CoV-2, providing the opportunity to analyse their contribution across organs. METHODS: We conducted a systematic review of 558 studies, divided into pandemic and post-pandemic periods, to assess how human models were applied to investigate host factors, viral replication of SARS-CoV-2, immune responses, and to evaluate reporting quality. FINDINGS: Our analysis revealed …

Rank97.7
Randomized controlled trial

Optimizing Web Links Used in Digital Vaccination Invitations to Raise Trust and Booking Intention: 3 Online Randomized Controlled Trials.

Journal of medical Internet research · 2026 · PMID 42640841

BACKGROUND: People are encouraged to respond swiftly to digital health invitations, but they can be (rightly) skeptical about their legitimacy. OBJECTIVE: Drawing on digital communication theory and psychological science, we hypothesized that easy-to-read web links that facilitate participants' ability to identify the health organization as the website host would improve trust in and user engagement with digital communications. METHODS: In 3 double-blind, randomized online experiments, adult UK residents were recru…

Rank97.6
Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.5
Randomized controlled trial

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

Human vaccines & immunotherapeutics · 2026 · PMID 41627968

A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase 1/2 clinical trial. This stratified, observer-blinded study randomly assigned healthy adults (18-75 years) to receive mRNA-1073 (25-µg, 50-µg, or 100-µg) + placebo, mRNA-1…

Rank97.3
Randomized controlled trial

Safety and immunogenicity of an mRNA COVID-19 vaccine administered to adults: A phase 2, randomized, active-controlled trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42647564

We conducted a phase 2, randomized, active-controlled, observer-blind study (NCT05960097) among healthy adults ≥18 y of age who completed a primary COVID-19 mRNA vaccination series, with or without a booster, ≥3 months earlier. Participants were randomized (1:1:1:1:1) to either receive an investigational bivalent mRNA COVID-19 vaccine encoding ancestral D614G and Omicron BA.4-5 spike proteins (CV0701 mRNA vaccine) at one of three dose levels, an investigational monovalent mRNA COVID-19 vaccine encoding the Omicron …

Rank97.2
Randomized controlled trial

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy · 2026 · PMID 42241901

BACKGROUND: During the COVID-19 pandemic, Mesenchymal Stromal Cells (MSCs) were rapidly proposed as a therapeutic option for Acute Respiratory Distress Syndrome (ARDS) based on their immunomodulatory properties. We report the results of COVIDMES, a multicenter trial initiated within a public blood and tissue bank infrastructure during unprecedented period of volatility and scientific uncertainty of the first pandemic waves. AIMS: To evaluate the safety, feasibility and exploratory efficacy of Wharton's Jelly-derive…

Rank96.4
Randomized controlled trialResult signal: harm

Humoral Response to COVID-19 Vaccines and Infection during Sibeprenlimab Treatment of IgA Nephropathy: Data from the ENVISION Trial.

Clinical journal of the American Society of Nephrology : CJASN · 2026 · PMID 42275148

KEY POINTS: The phase 2 ENVISION trial evaluated efficacy and safety of intravenous sibeprenlimab, a selective A PRoliferation-Inducing Ligand inhibitor. Because the trial was conducted during the coronavirus disease 2019 pandemic, we assessed if sibeprenlimab affected humoral responses to coronavirus disease 2019 infection or vaccine. Sibeprenlimab treatment resulted in reduced pathogenic IgA and preserved protective humoral response to coronavirus disease 2019 vaccine and infection. BACKGROUND: In phase 2 ENVISIO…

Rank96.3
Randomized controlled trial

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial.

Journal of biomedical science · 2026 · PMID 42601614

BACKGROUND: SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymerase gene, representing a strategy that may enable broader antiviral activity against emerging variants. METHODS: In this phase 2, double-blind, randomised, placebo-controlled trial, adults with mild-to-moderate COVID-19 within 3 days of symptom onset…

Rank95.2
Randomized controlled trial

Effects of incentive spirometer added to standard rehabilitation in previously hospitalized adults with post-COVID-19 condition: a randomized controlled trial.

Journal of rehabilitation medicine · 2026 · PMID 42084202

OBJECTIVE: Post-COVID-19 condition is associated with persistent respiratory symptoms and impaired functional capacity. This study evaluated the effects of adding an incentive spirometer to standard rehabilitation in adults with post-COVID-19 condition, with peak expiratory flow, dyspnoea, and quality of life as the prespecified primary outcomes. DESIGN: Randomized controlled trial. SUBJECTS/PATIENTS: Eighty-two previously hospitalized adults diagnosed with post-COVID-19 condition, were randomly assigned to an expe…

Rank95.1
Randomized controlled trial

Phase 1 trial of intranasal NDV-HXP-S in previously vaccinated adults.

Vaccine · 2026 · PMID 42378814

BACKGROUND: Newcastle disease virus hexapro spike (NDV-HXP-S) is a recombinant vaccine designed to elicit both systemic and mucosal immunity against SARS-CoV-2. Intramuscular vaccines protect against severe disease but provide limited mucosal protection. We conducted a Phase 1 trial of live NDV-HXP-S administered intranasally (IN), intramuscularly (IM), or simultaneously (IN+IM) in previously vaccinated adults. METHODS: Thirty-five healthy adults without prior COVID-19 were enrolled at a single site in New York Cit…

Rank95.0
Randomized controlled trial

A prematurely terminated phase 2, randomised trial to evaluate immunogenicity and reactogenicity of a single versus two-dose primary vaccination regimen of the mRNA vaccine BNT162b2 in previously SARS-CoV-2 infected children 5-11 years old (CoVacc trial).

Vaccine · 2026 · PMID 42364277

BACKGROUND: This open-label randomised phase 2 study aimed to determine whether a single versus two-dose BNT162b2 primary vaccination regimen in children 5 to 11 years old with prior SARS-CoV-2 infection was non-inferior in terms of immunogenicity and superior in terms of safety and reactogenicity. METHODS: Participants were randomly assigned (1:1) to receive either one or two doses, spaced 3 to 12-weeks. The primary endpoint was geometric mean ratio (GMR) of neutralizing antibodies against wild-type SARS-CoV-2 at …

Rank94.6
Randomized controlled trial

The Effects of Aromatherapy With Thyme Oil on Disease Symptoms, Vital Findings, and Hemodynamic Parameters in COVID-19 Patients: A Randomized Controlled Trial.

Holistic nursing practice · 2026 · PMID 40262016

The present study aimed to determine the effects of aromatherapy through thyme oil inhalation on respiratory symptoms, hemodynamic parameters and vital signs in COPD patients. The pre-test post-test randomized controlled experimental study was conducted with inpatients COPD (intervention group = 60, control group = 60). Data were collected using the "Patient Information Form", "COPD Symptoms Form", and "Hemodynamic Parameters and Vital Signs Monitoring Form" as well as a saturation device. Following the pre-test, p…

Rank92.0
Randomized controlled trialResult signal: null

The LTI-01-2001 phase 2a trial of intrapleural LTI-01 in patients with infected, non-draining pleural effusions.

Respiratory research · 2026 · PMID 42310706

BACKGROUND: Single chain urokinase (LTI-01) intrapleural enzymatic therapy (IET) was safe and promising in a phase 1 clinical trial to overcome failed drainage in patients with pleural infection. The LTI-01-2001 phase 2a trial was a randomized, double-blind, placebo-controlled, multi-center, dose-ranging study in hospitalized subjects with infected, non-draining pleural effusions. METHODS: LTI-01, in doses of 400,000, 800,000 or 1,200,000 Units, or placebo was administered intrapleurally once daily for up to 3 days…

Rank92.0
Randomized controlled trial

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42268674

This Phase 1 clinical trial evaluated the safety and immunogenicity of COVAC-2, a recombinant protein subunit vaccine as a heterologous booster in adults previously immunized with authorized COVID-19 vaccines (NCT05226702). COVAC-2 contains the SARS-CoV-2 S1 spike protein subunit adjuvanted with Sepivac SWE™, an open-access oil-in-water adjuvant. Sixty participants were randomized to receive a single intramuscular dose of COVAC-2 (10 µg or 25 µg) or placebo, with follow-up through Day 180. The vaccine was well tole…

Rank89.1
Randomized clinical study

Synchronous Remote Teaching for Neurological Examination Training in Fifth-Year Medical Students: Quasi-Experimental Study.

JMIR medical education · 2026 · PMID 42456133

BACKGROUND: The use of remote teaching in medical education has increased since the COVID-19 pandemic. However, the effectiveness of synchronous remote teaching for specific psychomotor components of the neurological examination, such as tendon reflex assessment, remains underexplored. OBJECTIVE: This study aimed to evaluate the short-term effectiveness of synchronous remote teaching compared with traditional in-person teaching for training medical students in tendon reflex examination skills and related neurologic…

Rank87.9
Randomized clinical study

Mobile-Based Cognitive Behavioral Therapy for Health Care Workers' Mental Health in Ecuador: Quasi-Experimental Study.

JMIR human factors · 2025 · PMID 40764043

BACKGROUND: Mental health challenges, including depression, anxiety, and burnout, have become increasingly prevalent among health care workers, who face high-stress environments, limited resources, and long working hours. The COVID-19 pandemic has intensified these issues, especially in regions like Latin America, where health care professionals experience heightened anxiety and depression. The urgent need for mental health support has prompted the development of mobile health (mHealth) solutions. These tools offer…

Rank85.0
Randomized clinical study

Virtual reality in nursing education: Integrating technology, pedagogy, and learning outcomes - A scoping review.

Nurse education in practice · 2026 · PMID 42492397

AIM: To map and synthesize how VR has been applied in nursing education by integrating technologies, pedagogical strategies, learning outcomes and implementation challenges. BACKGROUND: Virtual Reality (VR) has become an increasingly relevant educational tool in nursing education, particularly following the COVID-19 pandemic. However, evidence remains fragmented across technological, pedagogical and learning dimensions. METHODS: A scoping review was conducted according to the PRISMA Extension for Scoping Reviews (P…

Rank82.3
Phase II clinical trial

Lucinactant, a Synthetic Surfactant for the Treatment of Acute Respiratory Distress Syndrome Caused by COVID-19: Phase 1/2A Trial.

JMIR formative research · 2026 · PMID 42536986

BACKGROUND: One unique feature of COVID-19-associated acute respiratory distress syndrome (ARDS) is surfactant deficiency because SARS-CoV-2 specifically attacks alveolar type 2 cells. OBJECTIVE: In this study, we evaluated the effects of a synthetic surfactant (lucinactant) therapy in patients with COVID-19-associated ARDS. METHODS: This open-label multicenter phase 1/2A trial enrolled adult patients with COVID-19-associated ARDS who were within 7 days of mechanical ventilation initiation. Lucinactant (160 mL or a…

Rank73.0
Multicenter clinical study

Clinical and Cost-Effectiveness of Shared Decision Making: Evidence from a Prospective Multicenter Study Evaluating a Hospital-Based Intervention in Germany.

Medical decision making : an international journal of the Society for Medical Decision Making · 2026 · PMID 42249569

ObjectiveTo evaluate the clinical and cost-effectiveness of SHARE TO CARE (S2C), a complex intervention for hospital-wide, systematic implementation of shared decision making.MethodsWe analyzed clinical effectiveness, health care resource utilization, and implementation costs of S2C from the statutory health insurance perspective using a quasi-experimental difference-in-differences approach with evidence from the Department of Neurology. Clinical outcomes included inpatient hospital admissions, emergency department…

Rank70.5
Phase I clinical trial

Safety and efficacy of acalabrutinib plus bendamustine and rituximab in patients with treatment-naïve or relapsed/refractory mantle cell lymphoma: phase Ib trial.

Haematologica · 2025 · PMID 39234862

This multicenter, open-label, phase Ib study (ACE-LY-106) assessed the safety and efficacy of acalabrutinib, bendamustine, and rituximab (ABR) in treatment-naïve (TN) and relapsed or refractory (R/R) mantle cell lymphoma (MCL). Patients received acalabrutinib from cycle 1 until disease progression or treatment discontinuation, bendamustine on days 1 and 2 of each cycle for up to 6 cycles, and rituximab on day 1 of each cycle for 6 cycles, continuing every other cycle from cycle 8 for 12 additional doses (TN cohort)…

Rank65.0
Prospective cohort study

SARS-CoV-2 and diabetes: a post-pandemic reappraisal.

Diabetologia · 2026 · PMID 42362970

The COVID-19 pandemic was a dynamic and often confusing period for clinical and biomedical research. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread globally, knowledge accumulated rapidly through publications that were frequently based on preliminary or sometimes conflicting evidence, yet these papers played a critical role in shaping evolving medical, research and societal responses. Early in the pandemic, diabetes emerged as one of the strongest predictors of severe COVID-19 outcomes and m…

Rank51.3
Other PubMed-indexed publicationResult signal: null

Long-term follow-up of surgical complications and general health after preoperative optimisation for primary arthroplasty: a prospective quasi-experimental study.

BMJ open · 2026 · PMID 42562582

OBJECTIVES: Preoperative optimisation programmes aim to reduce complications after total joint arthroplasty (TJA), yet long-term effects on superficial surgical site infections (SSI), periprosthetic joint infections (PJI) and overall health remain unclear. This study evaluated the long-term impact of preoperative optimisation in cooperation with hospital and primary healthcare on infection outcomes and general health following elective primary lower extremity TJA. DESIGN: In this prospective quasi-experimental stud…

Rank50.4
Other PubMed-indexed publication

The effects of online intervention program implemented during COVID-19 on the quality of life and physical activities of individuals with intellectual disabilities and their mothers.

Journal of intellectual disabilities : JOID · 2026 · PMID 39134000

The aim of the study was to examine the effect of the Online Intervention Program implemented during the COVID-19 period on the quality of life (QoL) and physical activity (PA) levels of individuals with intellectual disability and their mothers. The experimental method was used in this study. A total of 184 people, 92 individuals with intellectual disability and their mothers participated in the study. By random assignment method, 40 participants with intellectual disability and their mothers were assigned to the …

Rank49.5
Other PubMed-indexed publication

Mobile application intervention for workplace resilience, self-efficacy, and depression in clinical nurses.

Archives of psychiatric nursing · 2026 · PMID 42608109

BACKGROUND: Clinical nurses are particularly vulnerable to stress and psychological distress during public health emergencies such as the COVID-19 pandemic. Workplace resilience is vital for mental health and professional functioning. Mobile app-based interventions offer accessible and flexible support in clinical practice. Such approaches may facilitate scalable support for healthcare workers in dynamic and high-demand settings. Clinical nurses face significant mental health challenges in the post-pandemic context…

Rank49.3
Other PubMed-indexed publication

Easing Cash Assistance Rules and Breastfeeding.

JAMA health forum · 2025 · PMID 40779256

IMPORTANCE: Temporary Assistance for Needy Families (TANF) is a major federal cash assistance program for low-income families, but the program has strict eligibility criteria, meager cash benefits, and cumbersome administrative burdens that limit its effect. However, during the COVID-19 pandemic state TANF programs implemented policy changes to expand program access, including relaxed work requirements and additional income. Few studies have examined the association of these policy changes with health outcomes. OBJ…

Prospective Cohort Studies89 records
Rank101.2
Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

BACKGROUND: The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we developed…

Rank97.2
Randomized controlled trial

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy · 2026 · PMID 42241901

BACKGROUND: During the COVID-19 pandemic, Mesenchymal Stromal Cells (MSCs) were rapidly proposed as a therapeutic option for Acute Respiratory Distress Syndrome (ARDS) based on their immunomodulatory properties. We report the results of COVIDMES, a multicenter trial initiated within a public blood and tissue bank infrastructure during unprecedented period of volatility and scientific uncertainty of the first pandemic waves. AIMS: To evaluate the safety, feasibility and exploratory efficacy of Wharton's Jelly-derive…

Rank96.4
Randomized controlled trial

Immunogenicity and Safety of 2 Versus 3 Doses of 9-Valent Vaccine Against Human Papillomavirus in Women With Human Immunodeficiency Virus: The Papillon Randomized Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 40356381

BACKGROUND: The World Health Organization recommends 2 doses of human papillomavirus (HPV) vaccine for adults without human immunodeficiency virus (HIV) but 3 doses in persons with HIV. There are no immunogenicity data on the 2-dose schedule in women with HIV (WWH). METHODS: This was a prospective study comparing 2 doses (months 0 and 6) versus 3 (months 0, 2, and 6) doses of 9-valent vaccine (Gardasil 9, Merck Sharp & Dohme) in WWH (15-40 years), on antiretrovirals with HIV RNA <400 copies/mL, enrolled during 2018…

Rank96.0
Systematic review or meta-analysis

Telemedicine-Enabled Surgical Outreach across the Surgical Continuum to Bridge the Gap in Low- and Middle-Income Countries: Lessons from the COVID-19 Era and Applications Beyond.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2026 · PMID 42176257

INTRODUCTION: Telemedicine has revolutionized health care delivery globally, reducing health care costs, increasing patient satisfaction, and improving surgical outcomes. Innovation is often born out of necessity, and during the Coronavirus disease 2019 (COVID-19) pandemic, there was a surge of telemedicine initiatives both in surgical education and surgical care delivery. This has been well documented in high-income countries, but there has been less evaluation of the use and potential application of telemedicine …

Rank95.5
Randomized controlled trialResult signal: null

Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study.

Inflammatory bowel diseases · 2026 · PMID 42322204

BACKGROUND AND AIMS: Changes to the oral microbiome have been reported in patients with Crohn's disease (CD). The aim of this study was to determine the characteristics and dynamics of the oral microbiome in children randomized to 1 of 2 nutritional treatments for CD. METHODS: Participants (n = 54) in this randomized controlled trial (NCT02843100) received the Crohn's Disease Exclusion Diet (CDED) with either partial enteral nutrition (PEN; n = 28) or exclusive enteral nutrition (EEN; n = 26). The oral microbiome w…

Rank94.9
Randomized controlled trial

Determining the optimal frequency of SARS-CoV-2 regular asymptomatic testing: A randomized feasibility trial in a home care setting.

PloS one · 2024 · PMID 38959206

BACKGROUND: The SARS-CoV-2 pandemic presented a challenge for caregiving relatives in the home care setting. Caregivers can transmit SARS-CoV-2 to their relatives who are often at high risk for a severe course of COVID-19. Regular testing of asymptomatic caregivers for SARS-CoV-2 may reduce the risk of transmission. The optimal method and frequency of regular asymptomatic testing is unknown. We conducted a prospective, randomised trial to assess the feasibility, recruitment and acceptance of different testing frequ…

Rank92.0
Randomized controlled trialResult signal: null

Intraocular Pressure Measurement Variability Associated With Face Mask Use.

Journal of glaucoma · 2026 · PMID 41885902

PRCIS: Masks have a multifactorial impact on intraocular pressure measured with the Goldmann tonometer, reaching clinical significance in one-third of patients. Before making clinical decisions, repeated measurements without a mask or other tonometers should be considered. PURPOSE: To investigate the impact of wearing face masks on intraocular pressure (IOP), the only manageable factor today in glaucoma, a blinding disease. Given the recurrent global outbreaks of respiratory infections (eg, COVID-19, RSV, and measl…

Rank92.0
Randomized controlled trial

Impact of COVID-19 Monoclonal Antibody Therapy on Subsequent Vaccine-Elicited SARS-CoV-2 Immune Responses.

The Journal of infectious diseases · 2026 · PMID 41700320

BACKGROUND: How anti-SARS-CoV-2 monoclonal antibodies (mAbs) change subsequent vaccine responses remains uncertain. METHODS: We conducted a prospective, phase IV, open-label study of adults who received mRNA-1273 or BNT162b2. Cohort 1 included outpatients with acute COVID-19 previously randomized to mAbs (tixagevimab/cilgavimab or amubarvimab/romlusevimab), camostat, or placebo in ACTIV-2/A5401. Cohort 2 included unvaccinated adults without reported prior COVID-19 and was analyzed as naive or non-naive by baseline …

Rank80.6
Multicenter clinical study

Biopsy-to-treatment delay in prostate cancer: Postpandemic impact in a swiss national, multicenter, prospective registry.

Urologic oncology · 2026 · PMID 42436100

BACKGROUND: Surgical delays increased during the COVID-19 pandemic. The effect of treatment delay in intermediate- and high-risk prostate cancer remains uncertain. We evaluated whether biopsy-to-surgery delay influences early oncological outcomes in a large contemporary cohort. METHODS: We analyzed 6,448 intermediate- or high-risk patients from the prospective Swiss national prostatectomy registry (2020-2025). Outcomes were: PSA persistence; adverse pathology (lymph-node invasion [LNI], extracapsular extension [ECE…

Rank79.2
Multicenter clinical study

Characterization of post-COVID syndrome by self-perceived symptom severity stratified by infection wave: beyond COVID, a prospective, multicenter cohort study in Germany.

Infection · 2026 · PMID 42149360

BACKGROUND: Post-COVID syndrome (PCS) refers to persistent or new-onset symptoms 3 months after SARS-CoV-2 infection lasting for at least 2 months. The characterization of PCS varies across studies, with a substantial heterogeneity regarding different study samples, survey instruments, and follow-up periods. This is particularly the case in hospitalized patients vs. outpatients, as well as regarding different variants of concern (VOCs) and their impact on the frequency and severity of specific symptoms. METHODS: Th…

Rank79.0
Multicenter clinical study

Association between corticosteroid therapy during acute COVID-19 and Long COVID symptoms: a propensity score overlap-weighted analysis.

Respiratory medicine · 2026 · PMID 42190841

BACKGROUND: The association between acute-phase corticosteroid therapy and subsequent Long COVID symptoms remains uncertain. Therefore, we aimed to evaluate the association between systemic corticosteroid therapy during hospitalization and patient-reported Long COVID symptoms during follow-up. METHODS: In this prospective multicenter observational study, we enrolled adults hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at 26 hospitals in Japan between J…

Rank78.4
Multicenter clinical study

Oropharyngeal swabs show higher bacterial loads than nasopharyngeal swabs for PCR detection of pertussis: a multicenter prospective study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42361964

OBJECTIVE: Pertussis remains a significant public health concern despite widespread vaccination, with a resurgence observed following the COVID-19 pandemic. The optimal sampling site for PCR-based detection of Bordetella pertussis remains uncertain. METHODS: We conducted a multicenter prospective study across five institutions in Japan between October 2024 and May 2025. A total of 475 patients presenting with cough were enrolled. Nasopharyngeal and oropharyngeal swabs were collected and analyzed using real-time pol…

Rank78.2
Multicenter clinical study

Impact of Age on Bleeding, Stroke, and Mortality in Edoxaban-Treated Patients with Atrial Fibrillation: Results from the ETAF-TR Registry.

Drugs & aging · 2026 · PMID 42455491

BACKGROUND: Data on age-specific outcomes in patients with atrial fibrillation (AF) treated with edoxaban in real-world settings are limited; this prespecified analysis of the ETAF-TR study aimed to investigate the influence of age on prespecified clinical outcomes, including overt bleeding, major bleeding, ischemic stroke, all-cause mortality, major adverse cardiovascular events (MACE), and net clinical benefit. METHODS: The ETAF-TR study is a prospective, multicenter, observational registry conducted at 50 cardio…

Rank76.5
Multicenter clinical study

Longitudinal assessment of health-related quality of life and clinical outcomes with at home advanced pneumatic compression treatment of lower extremity lymphedema.

Journal of vascular surgery. Venous and lymphatic disorders · 2024 · PMID 38636734

OBJECTIVE: This prospective, longitudinal, pragmatic study describes at home treatment with a proprietary advanced pneumatic compression device (APCD) for patients with lower extremity lymphedema (LED). METHODS: Following institutiona review board approval, four participating Veterans Affairs centers enrolled LED patients from 2016 to 2022. The primary outcome measures were health-related quality of life (HR-QoL) questionnaires (lymphedema quality of life-leg and the generic SF-36v2) obtained at baseline and 12, 24…

Rank75.9
Multicenter clinical studyResult signal: harm

High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

Journal of critical care · 2026 · PMID 42385526

BACKGROUND: Optimal corticosteroid dosing strategies remain unclear for severe coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU). This study compared mortality among patients treated with high-dose versus standard-dose corticosteroids. METHODS: This prospective cohort study included adult patients with COVID-19 ARDS, defined according to Berlin criteria for ARDS, across 22 centers in the Netherlands between March 2020 and January 2021. Mortality hazards were compared between pat…

Rank75.6
Multicenter clinical study

Longitudinal 1H and 129Xe Lung MRI in Patients With Post-COVID Residual Lung Abnormalities.

Journal of magnetic resonance imaging : JMRI · 2026 · PMID 42210667

BACKGROUND: It is unclear how lung function may recover in patients with residual lung abnormalities (RLAs) following COVID-19 pneumonia. PURPOSE: To evaluate lung function trends over time in patients with RLAs following hospitalization due to COVID-19. STUDY TYPE: Prospective, multicenter longitudinal cohort study. POPULATION: Twenty-four participants hospitalized due to COVID-19 with RLAs identified on CT ≥ 3 months postdischarge (median [IQR] age 69 (15) years; 3 female) underwent at least one MRI at 6 months (…

Rank75.5
Multicenter clinical study

Long COVID among the first three waves of COVID-19 in Japan: a multicentre cohort study.

BMJ open respiratory research · 2024 · PMID 39721744

OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 significantly impacts Japan with a high number of infections and deaths reported. Long coronavirus disease (COVID) characterised by persistent symptoms after COVID-19 has gained recognition but varies across studies. This study aimed to investigate the differences in long COVID among patients hospitalised during Japan's first three waves of the pandemic. DESIGN: Multicentre prospective cohort study. SETTING: 26 medical facilities across Japan between Febru…

Rank75.3
Multicenter clinical study

COVID-19 vaccination among people with HIV in Uganda: lessons from a high-risk group with high vaccine uptake for the next pandemic.

Vaccine · 2026 · PMID 42430873

BACKGROUND: Despite the effectiveness of the COVID-19 vaccine, vaccination rates vary across settings and populations, especially among people living with HIV (PLHIV). We assessed factors associated with COVID-19 vaccination among PLHIV in Mbarara, Uganda. METHODS: We conducted a cross-sectional, secondary analysis of a prospective cohort study consisting of PLHIV ≥18 years old on antiretroviral therapy (ART). We collected data on COVID-19 vaccine uptake and associated factors beginning in December 2021, 9 months a…

Rank75.0
Prospective cohort study

Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.

Scandinavian journal of primary health care · 2026 · PMID 41496460

BACKGROUND: Women are disproportionately diagnosed with symptom-based conditions, notably post-COVID condition (PCC). In Sweden, as of February 2022, 2.3% of PCR-verified female COVID-19 cases versus 1.6% of male cases had a PCC diagnosis. Post-viral fatigue syndrome (PVFS) and exhaustion disorder (ED), a common and relevant diagnosis in Sweden, share substantial symptom overlap with PCC. AIMS: To quantify the association between pre-pandemic, symptom-based primary-care visits and subsequent PCC, PVFS, and ED among…

Rank74.7
Multicenter clinical study

Impact of diagnostic delay in COVID-19 index cases on SARS-CoV-2 transmission to household contacts.

Medicina clinica · 2026 · PMID 42413342

INTRODUCTION: Diagnostic delay in COVID-19 index cases may increase household transmission of SARS-CoV-2. A prospective epidemiological study was conducted to analyze SARS-CoV-2 infection among household contacts of confirmed COVID-19 cases. METHODS: Recruitment of index cases and their household contacts took place in eight primary care centers. This study included 227 index cases and 329 household contacts and examined the association between the time from symptom onset to index case diagnosis and the household t…

Rank74.1
Prospective cohort study

Long COVID symptoms before and 3-35 months after SARS-CoV-2 infection in a Norwegian prospective cohort study, symptoms over the pandemic, and different virus variants.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42208931

OBJECTIVES: Examine long COVID symptoms and prevalence of symptoms over the pandemic and compare symptoms due to the Omicron variants with symptoms due to earlier variants of the SARS-CoV-2 virus. METHODS: In the present Norwegian prospective cohort study, 11,5737 persons, aged 18-96 years, completed 1-6 questionnaires 3-35 months after a positive and/or negative SARS-CoV-2 test between 2020 and 2023. RESULTS: The following symptoms were reported more frequently 3-35 months after than before a positive SARS-CoV-2 t…

Rank73.6
Multicenter clinical study

Pulmonary fibrosis followed by severe pneumonia in patients with COVID-19 infection requiring mechanical ventilation: a prospective multicentre study.

BMJ open respiratory research · 2024 · PMID 39366721

BACKGROUNDS: The management of lung complications, especially fibrosis, after COVID-19 pneumonia, is an important issue in the COVID-19 post-pandemic era. We aimed to investigate risk factors for pulmonary fibrosis development in patients with severe COVID-19 pneumonia. METHODS: Clinical and radiological data were prospectively collected from 64 patients who required mechanical ventilation due to COVID-19 pneumonia and were enrolled from eight hospitals in South Korea. Fibrotic changes on chest CT were evaluated by…

Rank73.6
Prospective cohort study

Effectiveness of Omicron JN.1 vaccination against infection with JN.1-derived SARS-CoV-2 subvariants in a prospective cohort study in the Netherlands.

Vaccine · 2026 · PMID 42585808

INTRODUCTION: We estimated vaccine effectiveness (VE) of JN.1 COVID-19 vaccination against SARS-CoV-2 infection by (sub)variant between 23 September 2024 and 23 February 2025. METHODS: JN.1 vaccine-eligible participants of an ongoing prospective cohort study (VAccine Study COvid-19; VASCO) were included: individuals aged ≥60 years, and individuals aged <60 years with a medical risk condition or who were healthcare workers. In VASCO, questionnaire and serology data are regularly collected and self-tests are provided…

Rank73.6
Multicenter clinical study

COVID-19 in people with Cystic Fibrosis beyond the pre-omicron era: a prospective study with a specific focus on long COVID.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026 · PMID 40908194

BACKGROUND: The long-term clinical consequences of COVID-19 in cystic fibrosis (CF) remain largely unexplored. This study aimed to assess the incidence of long COVID in a large population of people with CF. METHODS: This prospective, multicentre study enrolled individuals with confirmed SARS-CoV-2 infection between July 2021 and October 2022. Data collected included clinical features prior to infection, symptoms during the acute phase, hospitalization and symptom persistence after 1 and 6 months. Long COVID was def…

Rank73.3
Prospective cohort study

Association between post-vaccination adverse events and subsequent COVID-19 booster uptake in the Netherlands.

Vaccine · 2026 · PMID 42603508

INTRODUCTION: This study aimed to assess whether the occurrence, severity, and duration of AE following COVID-19 booster vaccination were associated with subsequent booster uptake during the 2022-2024 autumn booster campaigns in the Netherlands. METHODS: We included participants from the Vaccine Study COVID-19 (VASCO), an ongoing prospective cohort study, who were eligible for booster vaccination in 2022-2024. Participants completed a questionnaire on AE one month after booster vaccination. Logistic regression was …

Quality Of Life82 records
Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank106.0
Systematic review or meta-analysis

Post-Acute Sequelae of Non-COVID-19 Respiratory Viral Infections: A Systematic Review.

Respirology (Carlton, Vic.) · 2026 · PMID 42616003

Respiratory viral infections (RVIs) affect millions annually, yet long-term consequences outside COVID-19 are poorly defined. Post-acute sequelae, encompassing persistent or new physical, cognitive, and mental health impairments, are increasingly recognised as clinically important. We systematically reviewed evidence on post-acute outcomes in adults following non-COVID RVIs to characterise pathogen-specific patterns and highlight areas for future research. Major databases were searched from January 2004 to August 2…

Rank102.0
Systematic review or meta-analysis

Individual Participant Data Meta-Analysis (IPDMA) of long-term COVID-19 outcomes in a systematic review-informed, international, multidisciplinary database.

Health and social care delivery research · 2026 · PMID 42663308

BACKGROUND: Identifying and addressing long-term health and societal challenges after COVID-19 is a research priority. OBJECTIVES: To create an international, multidisciplinary COVID-19 database, and synthesise long-term outcomes, predictors and costs. DESIGN: Systematic identification of COVID-19 data sets and meta-analysis of individual participant data on long-term outcomes after COVID-19. SETTING: Contributed data were collected in clinical, community and research settings. INTERVENTIONS: Interventions from ori…

Rank100.0
Systematic review or meta-analysis

The Impact of Pulmonary Rehabilitation in Patients with Post-COVID-19 Syndrome: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42646577

BACKGROUND: Post-COVID-19 syndrome represents a global health problem, manifesting with persistent multiple organ symptoms, including respiratory ones. This review aimed to evaluate the efficacy of different pulmonary rehabilitation interventions in the management of the disease, including its particularities. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) statement and prospectively registered in the PROSPERO dat…

Rank100.0
Systematic review or meta-analysis

Psychological interventions for individuals with long COVID: a systematic review and meta-analysis.

Health psychology review · 2026 · PMID 41880671

INTRODUCTION: Long COVID involves a variety of persistent symptoms after initial SARS-CoV-2 infection, affects multiple functional areas and requires multidisciplinary treatment. OBJECTIVE: This study aimed to explore the available evidence about psychological interventions for individuals with long COVID and their effectiveness in reducing some prevalent symptoms, such as fatigue, anxiety or depression, among others, and improving patient quality of life. METHODOLOGY: A systematic review and meta-analysis were con…

Rank100.0
Systematic review or meta-analysis

Cost-Effectiveness of Virtual Emergency Care Models: Systematic Review.

JMIR mHealth and uHealth · 2026 · PMID 42555953

BACKGROUND: Virtual care technologies have rapidly expanded in emergency medicine, particularly following the COVID-19 pandemic. However, comprehensive economic evaluations of their cost-effectiveness remain fragmented across different clinical applications and health care settings, creating uncertainty for policymakers and health care administrators considering implementation. OBJECTIVE: This study aimed to systematically review and synthesize evidence on the cost-effectiveness of virtual emergency care models com…

Rank98.0
Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

CONTEXT: Advanced care planning (ACP) can reduce hospitalizations, increase quality of life, and align treatment with patient wishes, while lowering healthcare costs. However, healthcare providers' discomfort, lack of training, and patient anxiety may hinder ACP. Furthermore, disparities exist among minority and low-income groups. Growing research highlights the need for standardized definitions and broader implementation, especially post-COVID-19, incorporating digital tools, economic impacts, ethics, and family r…

Rank96.3
Randomized controlled trial

Effectiveness of adapted physical activity and therapeutic exercise programme in improving chronic fatigue syndrome in long COVID, delivered via hospital-based rehabilitation versus telerehabilitation.

Trials · 2026 · PMID 42310705

BACKGROUND: Long COVID is a prevalent condition characterised by pain, fatigue, disability, and a multitude of health issues. There are various treatment options for managing long COVID symptoms, including non-pharmacological interventions like physiotherapy and rehabilitation, which can be effectively delivered either in institutional care settings or via telerehabilitation. METHODS: This three-arm randomised controlled trial included 145 participants selected from a population-based cohort in eight administrative…

Rank96.2
Randomized controlled trial

Center- vs Home-Based Cardiac Rehabilitation in Patients With Heart Failure: EXIT-HF Randomized Controlled Trial.

JACC. Heart failure · 2025 · PMID 39895436

BACKGROUND: Despite being an evidence-based intervention, the implementation of cardiac rehabilitation (CR) is often unsatisfactory, especially among patients with heart failure (HF). Home-based CR can serve as an alternative to improve accessibility for patients unable to participate in center-based programs. OBJECTIVES: The study sought to compare the clinical impact of center- vs home-based CR in HF patients. METHODS: Single-center, parallel group, noninferiority trial, enrolling HF patients irrespective of ejec…

Rank95.2
Randomized controlled trial

Effects of incentive spirometer added to standard rehabilitation in previously hospitalized adults with post-COVID-19 condition: a randomized controlled trial.

Journal of rehabilitation medicine · 2026 · PMID 42084202

OBJECTIVE: Post-COVID-19 condition is associated with persistent respiratory symptoms and impaired functional capacity. This study evaluated the effects of adding an incentive spirometer to standard rehabilitation in adults with post-COVID-19 condition, with peak expiratory flow, dyspnoea, and quality of life as the prespecified primary outcomes. DESIGN: Randomized controlled trial. SUBJECTS/PATIENTS: Eighty-two previously hospitalized adults diagnosed with post-COVID-19 condition, were randomly assigned to an expe…

Rank94.8
Randomized controlled trialResult signal: benefit

VSL#3® supplementation improves fatigue in long COVID: results from the DELong#3 randomized placebo-controlled trial.

British journal of biomedical science · 2026 · PMID 42577968

BACKGROUND: Long COVID is frequently characterized by persistent fatigue and impaired quality of life. Increasing evidence suggests that gut microbiota dysbiosis and immune dysregulation may contribute to symptom persistence. We evaluated the effects of the probiotic formulation VSL#3® in patients with long COVID. METHODS: In this randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT05874089), patients with long COVID and clinically relevant fatigue received VSL#3® or placebo for 4 …

Rank92.0
Randomized clinical study

Herbal medicine (Kyungok-go) for fatigue in Long COVID patients: A prospective multicenter pilot study.

Integrative medicine research · 2026 · PMID 42088012

BACKGROUND: Long COVID, defined as symptoms persisting beyond 12 weeks after acute SARS-CoV-2 infection, has emerged as a significant global health concern. Fatigue is one of its most common and disabling symptoms, yet robust clinical evidence for effective treatments remains limited. METHODS: We conducted a multicenter, prospective, single-arm pilot study to evaluate the feasibility and potential effectiveness of Kyungok-go (Qiong-Yu-Gao), a traditional Korean herbal medicine, in individuals with Long COVID-relate…

Rank92.0
Randomized controlled trial

Telehealth-delivered group-based exercise therapy and education for knee osteoarthritis: A non-inferiority randomised clinical trial disrupted by COVID-19.

Journal of telemedicine and telecare · 2026 · PMID 41505342

ObjectiveInability to attend in-person care is a common barrier to accessing exercise therapy and education programs for knee osteoarthritis. The primary aim of this randomised clinical trial (RCT) was to determine if telehealth was non-inferior to 'in-person' delivery of a group-based exercise therapy and education program (GLA:D®) for knee-related burden at 3 (primary timepoint), 12 and 24 months in people with knee osteoarthritis.DesignThis pre-registered (ACTRN12619000235101) two-arm (in-person v telehealth) no…

Rank91.6
Randomized clinical study

Randomised controlled trial assessing the efficacy of balance acceptance and commitment therapy (ACT) for post-COVID syndrome: a study protocol.

BMJ open · 2026 · PMID 42547235

INTRODUCTION: Post-COVID syndrome (PCS) is an ongoing legacy of the SARS-CoV-2 pandemic. Defined as symptoms persisting beyond 12 weeks following SARS-CoV-2 infection unexplained by an alternative diagnosis, many individuals continue to experience symptoms for months post-infection. Fatigue, breathlessness, cognitive difficulties and sleep disturbances are all commonly reported, frequently impairing daily functioning and quality of life. Acceptance and commitment therapy (ACT), which enhances psychological flexibil…

Rank91.4
Randomized clinical study

Deucravacitinib 5-Year Safety and Efficacy Results in Plaque Psoriasis: A Phase 3 Open-Label Extension of Randomized Clinical Trials.

American journal of clinical dermatology · 2026 · PMID 42563042

BACKGROUND: Deucravacitinib, an oral, selective, tyrosine kinase 2 inhibitor, is approved for adults with moderate to severe plaque psoriasis who are candidates for systemic therapy and for adults with active psoriatic arthritis. OBJECTIVE: We evaluated deucravacitinib safety and efficacy over 5 years in the phase 3 POETYK PSO-1, PSO-2, and long-term extension (LTE) trials in patients with moderate to severe plaque psoriasis. METHODS: PSO-1 and PSO-2 (parent trials) randomized patients 1:2:1 to oral placebo, deucra…

Rank89.0
Randomized clinical study

Benralizumab in bronchiectasis: results from the phase 3 MAHALE study.

ERJ open research · 2026 · PMID 42639375

BACKGROUND: Bronchiectasis is a chronic, inflammatory lung disease with distinct endotypes, often defined by inflammatory cells in blood and sputum. We assessed safety and efficacy of benralizumab, an anti-interleukin-5Rα monoclonal antibody, in patients with bronchiectasis and eosinophilic inflammation. METHODS: MAHALE (NCT05006573) was a 52-week, randomised, multicentre, double-blind, phase 3 study. Patients with bronchiectasis and no comorbid pulmonary conditions were randomised 1:1 to receive subcutaneous benra…

Rank87.4
Randomized clinical study

Potential Adjunctive Effects of Quercetin-Curcumin Co-Supplementation in Adults with Mild-to-Moderate Long COVID: Results from a Pragmatic Exploratory Real-World Clinical Study.

Pharmaceuticals (Basel, Switzerland) · 2026 · PMID 42653699

Background/Objectives: Long COVID is characterised by persistent symptoms such as fatigue, pain, cognitive impairment, sleep disturbances, and reduced quality of life (QoL) following SARS-CoV-2 infection. Proposed mechanisms include persistent immune activation, chronic inflammation, oxidative stress, endothelial dysfunction, mitochondrial disturbances, and virus-induced cellular senescence. Current management is largely supportive, highlighting the need for complementary strategies targeting these pathways. Natura…

Rank87.0
Randomized clinical study

REenergizeME: intermittent hypoxia-hyperoxia treatment for myalgic encephalomyelitis/chronic fatigue syndrome-protocol for a randomised, placebo-controlled trial.

BMJ open · 2026 · PMID 42601095

INTRODUCTION: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, disabling condition characterised by post-exertional malaise (PEM), autonomic dysfunction and markedly reduced quality of life. Its prevalence has increased following the COVID-19 pandemic, yet no effective disease-modifying treatments are available and underlying mechanisms remain unclear. Evidence implicates immune-metabolic dysregulation, impaired energy metabolism, vascular dysfunction and altered oxygen handling. Intermitte…

Rank86.8
Randomized clinical study

A Visual Telerehabilitation Program in Virtual Reality for Age-Related Macular Degeneration: Randomized Feasibility and Proof-of-Concept Trial.

JMIR rehabilitation and assistive technologies · 2026 · PMID 42546222

BACKGROUND: Age-related macular degeneration (AMD) causes progressive central vision loss in older adults. Low-vision rehabilitation can improve functional vision by training the use of a preferred retinal locus, commonly through clinic-based biofeedback training (BFT). However, repeated supervised rehabilitation is burdensome, and functional gains may be difficult to sustain without home practice. Stand-alone virtual reality (VR) may enable home-based, remotely monitored visual stimulation, but feasibility, safety…

Rank85.0
Randomized clinical studyResult signal: harm

Occupational Contact Dermatitis in the Post-COVID Era: From Barrier Dysfunction and Microbiome Dysbiosis to Prevention and Precision Management.

Journal of clinical medicine · 2026 · PMID 42652757

Background/Objectives: Occupational contact dermatitis (OCD) is the most common work-related skin disease, accounting for roughly 90-95% of occupational dermatoses and falling predominantly on the hands. It is rarely dangerous yet imposes a substantial burden through impaired quality of life, lost productivity, and premature exit from affected trades. The COVID-19 pandemic intensified this burden among healthcare workers, in whom the pooled one-year prevalence of self-reported hand eczema reaches around 27%; meta-a…

Rank79.0
Multicenter clinical study

Association between corticosteroid therapy during acute COVID-19 and Long COVID symptoms: a propensity score overlap-weighted analysis.

Respiratory medicine · 2026 · PMID 42190841

BACKGROUND: The association between acute-phase corticosteroid therapy and subsequent Long COVID symptoms remains uncertain. Therefore, we aimed to evaluate the association between systemic corticosteroid therapy during hospitalization and patient-reported Long COVID symptoms during follow-up. METHODS: In this prospective multicenter observational study, we enrolled adults hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at 26 hospitals in Japan between J…

Rank77.7
Multicenter clinical study

Post-Intensive Care Syndrome in COVID-19 Patients in Spanish ICUs. One-Year Follow-Up. CoronaPICS Study.

Journal of intensive care medicine · 2026 · PMID 41739591

PurposeTo characterize post-intensive care syndrome (PICS) in critical patients who survived COVID-19 during the first pandemic wave and to follow PICS symptoms during one year.Material and methodsProspective, observational, multicenter cohort study conducted in 11 Spanish ICUs. Critically ill adult patients who survived SARS-CoV-2 infection and met risk criteria for PICS were included. In-person follow-up was conducted at 3, 6, and 12 months after hospital discharge, assessing physical, cognitive, psychological, a…

Rank76.5
Multicenter clinical study

Longitudinal assessment of health-related quality of life and clinical outcomes with at home advanced pneumatic compression treatment of lower extremity lymphedema.

Journal of vascular surgery. Venous and lymphatic disorders · 2024 · PMID 38636734

OBJECTIVE: This prospective, longitudinal, pragmatic study describes at home treatment with a proprietary advanced pneumatic compression device (APCD) for patients with lower extremity lymphedema (LED). METHODS: Following institutiona review board approval, four participating Veterans Affairs centers enrolled LED patients from 2016 to 2022. The primary outcome measures were health-related quality of life (HR-QoL) questionnaires (lymphedema quality of life-leg and the generic SF-36v2) obtained at baseline and 12, 24…

Rank71.8
Prospective cohort study

Olfactory dysfunction in SARS-CoV-2 infection: 12 month trajectory of psychophysical tests.

American journal of otolaryngology · 2026 · PMID 42628245

AIM: To report olfactory dysfunction (OD) as measured by psychophysical testing in the post-acute COVID-19 patient over a 12-month period; to correlate this with patient-reported quality of life (QOL) outcomes. METHODS: In this multi-centre UK prospective cohort, adults with confirmed COVID-19 completed the University of Pennsylvania Smell Identification Test (UPSIT), the validated Sinonasal Outcome Test-22 (SNOT-22) and the English Questionnaire of Olfactory Disorders (eODQ) at baseline (median 3 months after infe…

Rank65.0
Prospective cohort study

Correlates of fatigue in SARS-CoV-2-positive and -negative adolescents and young adults: Repeated cross-sectional analyses from a prospective cohort study.

Journal of psychosomatic research · 2026 · PMID 42235362

PURPOSE: To investigate cross-sectional associations between concurrent fatigue and a range of covariates in adolescents and young adults with acute SARS-CoV-2 infection and follow-up six months after infection, as well as in SARS-CoV-2-negative controls. METHODS: A total of 404 SARS-CoV-2 -positive adolescents and young adults were studied during their infection and again six months post-infection, compared to 105 SARS-CoV-2-negative controls. In this exploratory study, cross-sectional linear regression analyses w…

Randomized Controlled Trials138 records
Rank110.0
Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766598

Immunocompromised individuals experience disproportionately severe outcomes from respiratory syncytial virus (RSV) infection, yet direct evidence to guide vaccination in this population remains limited. To support clinical and shared decision-making for the 2025-2026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary expert panel to develop rapid, evidence-based recommendations on RSV vaccination among immunocompromised adults and children. The panel conducted a…

Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank106.1
Systematic review or meta-analysis

Effects of different exercise training modalities in post-COVID-19 individuals: a systematic review of randomized controlled trials.

Disability and rehabilitation · 2026 · PMID 41622853

PURPOSE: Although the COVID-19 pandemic has ended, long-term effects persist. Exercise training (ET) supports recovery, but evidence on optimal modalities is limited. This study evaluated the effects of different ET modalities in post-COVID-19 individuals. METHODS: A systematic search identified randomized controlled trials (RCTs) up to 23 September 2025, involving adults with COVID-19. Studies compared ≥4-week interventions-aerobic training, high-intensity interval training (HIIT), or combined training (aerobic pl…

Rank104.6
Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

OBJECTIVES: The reporting of patient-important outcomes (PIOs) in randomized controlled trials (RCTs) for COVID-19 varies widely, limiting their application in clinical decision-making. We evaluated how often PIOs were reported as primary outcomes in RCTs of COVID-19 treatments and identified trial characteristics associated with their reporting. STUDY DESIGN AND SETTING: This meta-epidemiological study analyzed primary outcome data from 102 RCTs evaluating COVID-19 treatments. RESULTS: Mortality outcomes were more…

Rank103.8
Systematic review or meta-analysis

Implications for future pandemics from a living systematic review and critical evaluation of observational studies of the effectiveness of COVID-19 vaccination against the Omicron variant.

Vaccine · 2026 · PMID 42594644

Reliable evidence on COVID-19 vaccine effectiveness during the period of Omicron variant predominance was essential to inform global vaccination strategies. Our living systematic review, commissioned by the World Health Organization (WHO), was established to provide an ongoing synthesis and critical appraisal of comparative observational studies evaluating the effectiveness of vaccines against COVID-19/SARS-CoV-2 infection caused by the Omicron variant. Weekly searches covering seven databases up to 31 December 202…

Rank103.8
Systematic review or meta-analysisResult signal: benefitCorrection flagged

Effects of Telehealth Interventions for People With Parkinson Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR mHealth and uHealth · 2026 · PMID 41604670

BACKGROUND: The global integration of telehealth into the management of Parkinson disease (PD) addresses critical gaps in health care access, especially for patients with limited mobility in underserved regions. Despite accelerated adoption during the COVID-19 pandemic, evidence regarding telehealth's multidimensional efficacy remains inconsistent. Previous meta-analyses reported conflicting outcomes for quality of life (QOL), motor symptoms, and neuropsychiatric comorbidities. OBJECTIVE: This study aimed to quanti…

Rank102.0
Systematic review or meta-analysis

Individual Participant Data Meta-Analysis (IPDMA) of long-term COVID-19 outcomes in a systematic review-informed, international, multidisciplinary database.

Health and social care delivery research · 2026 · PMID 42663308

BACKGROUND: Identifying and addressing long-term health and societal challenges after COVID-19 is a research priority. OBJECTIVES: To create an international, multidisciplinary COVID-19 database, and synthesise long-term outcomes, predictors and costs. DESIGN: Systematic identification of COVID-19 data sets and meta-analysis of individual participant data on long-term outcomes after COVID-19. SETTING: Contributed data were collected in clinical, community and research settings. INTERVENTIONS: Interventions from ori…

Rank101.2
Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

BACKGROUND: The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we developed…

Rank101.1
Randomized controlled trial

Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial.

Nature medicine · 2026 · PMID 42521821

Combining multidisciplinary care plans into integrated care pathways (ICPs) is scalable, generalizable and effective for several long-term conditions, but not evaluated in Long COVID (LC). Our phase 3, cluster-randomized, multicenter clinical trial investigated the effectiveness of ICP interventions for LC. Recruitment of adults ≥18 years with LC was conducted in 6 National Health Service LC clinics in England with specialist ICPs. The intervention arms were (i) multi-organ magnetic resonance imaging (MRI; Coversca…

Rank100.7
Randomized controlled trial

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine · 2026 · PMID 42398333

BACKGROUND: S-268024 is a recombinant protein vaccine developed as a COVID-19 booster. METHODS: This randomized, observer-blind, phase 3 study enrolled previously vaccinated Japanese adults without a history of SARS-CoV-2 infection. The noninferiority of the immunogenicity of the S-268024 booster vaccination versus NVX-CoV2373 was assessed. RESULTS: The immunogenicity population included 733 (S-268024 group: n = 368; NVX-CoV2373 group: n = 365) of 734 randomized participants. The geometric mean titer (GMT) ratio (9…

Rank100.3
Randomized controlled trial

Identification of HIF1A as a therapeutic target during SARS-CoV-2-associated lung injury.

JCI insight · 2025 · PMID 40526427

Hypoxia-inducible factors (HIFs) promote lung protection and pathogen eradication during acute lung injury. We, therefore, tested the theory that pharmacologic stabilization of HIFs dampens lung injury during SARS-CoV-2 pneumonia. Initial studies in murine SARS-CoV-2 models showed improved outcomes after treatment with the FDA-approved HIF stabilizer vadadustat. Subsequent studies in genetic models implicated alveolus-expressed Hif1a in mediating lung protection. Therefore, we performed a randomized, double-blinded…

Rank100.2
Randomized controlled trial

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19.

Critical care explorations · 2026 · PMID 42329789

OBJECTIVES: Understanding the mechanistic impact of fostamatinib, a spleen tyrosine kinase inhibitor, in severe COVID-19 using biomarkers associated with disease severity is crucial for the development of host-directed therapeutics. We analyzed samples from a randomized clinical trial to investigate the impact of fostamatinib on multiple inflammatory biomarkers associated with COVID-19 disease severity. DESIGN: Secondary analyses of biomarkers from a randomized clinical trial. SETTING: Multicenter randomized clinic…

Rank100.2
Randomized controlled trial

Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.

Expert review of respiratory medicine · 2026 · PMID 42261259

BACKGROUND: Bovhyaluronidase azoximer (BA) has been reported to improve pulmonary function and exercise tolerance in patients with pulmonary sequelae of COVID-19. In this multicenter, randomized, double-blind, placebo-controlled study, we evaluated the effects of BA on patients with long-term (up to 12 months) pulmonary sequelae of COVID-19. METHODS: Patients (n = 392) were randomized 1:1 to receive BA or placebo every 5 days for 71 days. Percent predicted forced vital capacity (ppFVC), respiratory symptoms, and ex…

Rank100.0
Systematic review or meta-analysis

The Impact of Pulmonary Rehabilitation in Patients with Post-COVID-19 Syndrome: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42646577

BACKGROUND: Post-COVID-19 syndrome represents a global health problem, manifesting with persistent multiple organ symptoms, including respiratory ones. This review aimed to evaluate the efficacy of different pulmonary rehabilitation interventions in the management of the disease, including its particularities. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) statement and prospectively registered in the PROSPERO dat…

Rank100.0
Randomized controlled trial

Immune correlates analysis in NextCOVE trial for a next-generation mRNA-1283 COVID-19 vaccine.

Human vaccines & immunotherapeutics · 2026 · PMID 42220116

SARS-CoV-2 neutralizing antibodies (nAbs) are strongly inversely associated with COVID-19 risk and have correlated with vaccine efficacy across multiple clinical trials conducted during the COVID-19 pandemic. As SARS-CoV-2 continues to evolve in the endemic era, it is important to determine whether nAb levels remain a valid statistical correlate of protection and potential surrogate endpoints for emerging variants. The next-generation COVID-19 vaccine, mRNA-1283, has recently received regulatory approval worldwide.…

Rank100.0
Systematic review or meta-analysis

Approaches to observational study designs and analytical options to evaluate the safety of multi-dose vaccines: a systematic review.

Expert review of vaccines · 2026 · PMID 42057741

INTRODUCTION: Observational studies require careful considerations when evaluating the safety of multidose vaccines. We reviewed design and analytical approaches in observational studies evaluating the safety of multidose vaccines in the post-licensure phase. METHODS: EMBASE, MEDLINE, Web of Science, and Scopus (2018-2022) were searched for hypothesis-testing studies evaluating the safety of multidose vaccines. Key features from frequently used designs were extracted. RESULTS: Among 123 eligible studies, cohort (46…

Rank100.0
Systematic review or meta-analysis

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review.

Journal of psychosomatic obstetrics and gynaecology · 2026 · PMID 42578412

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circumstances. OBJECTIVE: This systematic review aimed to provide an overview of psychological interventions for pregnant women during the COVID-19 pandemic and to evaluate their effectiveness in reducing distress and enhancing resilience. METHO…

Rank99.9
Randomized controlled trial

Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial.

Nature communications · 2026 · PMID 42533000

Persistent cardiac symptoms are common in post-COVID syndrome, even without structural heart disease. Evidence implicates immune dysregulation, endothelial dysfunction and low-grade cardiovascular inflammation. Yet no targeted treatment exists. Myoflame-19 is a multicenter, double-blind clinical trial of 279 participants with inflammatory cardiac involvement defined by cardiovascular magnetic resonance, randomized 1:1 to losartan plus prednisolone (n = 139) or matching placebos (n = 140) for 16 weeks. The modified …

Rank99.9
Randomized controlled trial

A process evaluation of a randomized clinical trial of selective decontamination of the digestive tract in ventilated adults admitted to intensive care: the SuDDICU PE study.

Trials · 2026 · PMID 42642777

BACKGROUND: The SuDDICU trial evaluated the effectiveness of selective digestive decontamination (SDD), a prophylactic antibiotic regimen comprising oral, gastric and intravenous (IV) components in ventilated adults admitted to intensive care. The trial recruited 9289 participants in 26 clusters across Australia and Canada. There was no difference in the primary outcome of in-hospital mortality, but a reduction in new positive blood cultures and antibiotic organisms. We conducted a concomitant process evaluation in…

Rank99.5
Randomized controlled trial

Evaluation of patient centred digital adherence technology for tuberculosis treatment outcomes: pragmatic randomised controlled trial.

BMJ (Clinical research ed.) · 2026 · PMID 42562413

OBJECTIVE: To evaluate the effectiveness of Tuberculosis Treatment Support Tools (TB-TST), a patient centred digital adherence technology, in improving treatment outcomes among individuals with drug susceptible tuberculosis in Argentina. DESIGN: Pragmatic, two arm, parallel randomised controlled trial. SETTING: Four public reference hospitals in Buenos Aires, Argentina. PARTICIPANTS: 555 patients aged ≥16 years with newly diagnosed drug susceptible tuberculosis, recruited between November 2020 and July 2023, random…

Rank99.5
Randomized controlled trialResult signal: null

Ensitrelvir for the Treatment of Hospitalized Adults With COVID-19: An International Phase 3 Randomized Placebo-controlled Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 42017206

BACKGROUND: Antivirals remain an important treatment strategy for persons who experience severe and life-threatening COVID-19. Ensitrelvir is an oral 3CL protease inhibitor with potent antiviral activity. METHODS: We conducted an international randomized, placebo-controlled trial of ensitrelvir with standard of care (SOC) among adults hospitalized for COVID-19. The primary outcome was clinical recovery assessed by the days to recovery scale through day 60 (DRS-60), analyzed using a Van Elteren test. RESULTS: From 2…

Rank99.4
Randomized controlled trial

Effect of PCSK9 inhibitor usage on coronary endothelial dysfunction in patients with hypercholesterolemia after coronary stenting: The CuVIC-2 trial.

Journal of cardiology · 2025 · PMID 40221085

BACKGROUND: The effects of evolocumab on coronary endothelial dysfunction (CED), a hallmark of atherogenesis, are unknown. The aim of this study was to investigate whether evolocumab, in combination with high-dose statins, could ameliorate CED in patients who underwent coronary stenting. METHODS: The CuVIC-2 trial was a multicenter randomized controlled trial. CED was defined as intracoronary acetylcholine (ACh)-induced contractile responses with signs of myocardial ischemia. We originally intended to enroll 160 pa…

Rank99.1
Randomized controlled trial

"How" Versus "Why" Messaging to Increase Uptake of Booster Vaccination Against COVID-19: Results of a Pragmatic Randomized Trial.

Journal of general internal medicine · 2024 · PMID 37932539

BACKGROUND: Messages aimed at increasing uptake of vaccines have been modestly successful, perhaps in part because they often focus on why individuals should receive a vaccine. Construal Level Theory posits that messages emphasizing "how" to get a vaccine may be more effective at encouraging vaccination than emphasizing "why." This message framing may be particularly important for COVID-19 booster acceptance. OBJECTIVE: To determine if pre-visit patient portal messages designed using Construal Level Theory increase…

Rank98.9
Randomized controlled trial

Cognitive Rehabilitation and Functional Outcomes in Long COVID-Related Cognitive Impairment: A Randomized Clinical Trial.

JAMA network open · 2026 · PMID 42384384

IMPORTANCE: Cognitive impairment is common in long COVID and severely affects daily life, with no proven treatments to date. OBJECTIVE: To evaluate the ability of cognitive rehabilitation (CR) to improve goal attainment, cognitive, and clinical outcomes in individuals with cognitive impairment as part of long COVID. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, single-blind, 2-arm, parallel-group randomized clinical trial was conducted at 3 sites in England between February 2023 and March 2024. Participants …

Rank98.6
Randomized controlled trial

Immunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

Vaccine · 2026 · PMID 42531981

A multicomponent vaccine targeting seasonal influenza and coronavirus disease 2019 (COVID-19) may reduce disease burden by providing simultaneous protection in a single injection. We report findings from Part 1 (Japan) of a phase 3, Asia-Pacific, randomized, observer-blind study evaluating immunogenicity, reactogenicity, and safety of mRNA-based multicomponent vaccine mRNA-1083, combining influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens. Participants aged ≥50 years were randomized…

Safety And Adverse Effects160 records
Rank110.0
Clinical guideline or consensus statement

HRS/ACC scientific statement: Guiding principles on same-day discharge for intracardiac catheter ablation procedures.

Heart rhythm · 2025 · PMID 40272340

Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown. Access challenges (exacerbated during the COVID-19 public health emergency) and economic pressures have driven a shift in practi…

Rank107.8
Systematic review or meta-analysis

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 2026 · PMID 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a selective If channel inhibitor, reduces heart rate without affecting blood pressure or myocardial contractility, making it a promising option, particularly in post-COVID-19 POTS. This systematic review and meta-analysis eval…

Rank100.7
Randomized controlled trial

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine · 2026 · PMID 42398333

BACKGROUND: S-268024 is a recombinant protein vaccine developed as a COVID-19 booster. METHODS: This randomized, observer-blind, phase 3 study enrolled previously vaccinated Japanese adults without a history of SARS-CoV-2 infection. The noninferiority of the immunogenicity of the S-268024 booster vaccination versus NVX-CoV2373 was assessed. RESULTS: The immunogenicity population included 733 (S-268024 group: n = 368; NVX-CoV2373 group: n = 365) of 734 randomized participants. The geometric mean titer (GMT) ratio (9…

Rank100.3
Randomized controlled trial

Identification of HIF1A as a therapeutic target during SARS-CoV-2-associated lung injury.

JCI insight · 2025 · PMID 40526427

Hypoxia-inducible factors (HIFs) promote lung protection and pathogen eradication during acute lung injury. We, therefore, tested the theory that pharmacologic stabilization of HIFs dampens lung injury during SARS-CoV-2 pneumonia. Initial studies in murine SARS-CoV-2 models showed improved outcomes after treatment with the FDA-approved HIF stabilizer vadadustat. Subsequent studies in genetic models implicated alveolus-expressed Hif1a in mediating lung protection. Therefore, we performed a randomized, double-blinded…

Rank100.0
Systematic review or meta-analysis

Approaches to observational study designs and analytical options to evaluate the safety of multi-dose vaccines: a systematic review.

Expert review of vaccines · 2026 · PMID 42057741

INTRODUCTION: Observational studies require careful considerations when evaluating the safety of multidose vaccines. We reviewed design and analytical approaches in observational studies evaluating the safety of multidose vaccines in the post-licensure phase. METHODS: EMBASE, MEDLINE, Web of Science, and Scopus (2018-2022) were searched for hypothesis-testing studies evaluating the safety of multidose vaccines. Key features from frequently used designs were extracted. RESULTS: Among 123 eligible studies, cohort (46…

Rank100.0
Systematic review or meta-analysis

Stroke risk following BNT162b2 vaccination: a systematic review and meta-analysis of self-controlled case series studies.

Expert review of vaccines · 2026 · PMID 42661284

INTRODUCTION: Whether BNT162b2 (Pfizer-BioNTech) vaccination increases stroke risk remains a public health concern. This is the first meta-analysis to synthesize self-controlled case series (SCCS)-derived stroke risk estimates specifically for BNT162b2 vaccination. METHODS: PubMed and Embase were searched from inception through 9 May 2026, following PRISMA 2020 guidelines. Eight eligible SCCS studies were pooled using a random-effects model with restricted maximum likelihood (REML) estimation and the Knapp-Hartung …

Rank100.0
Systematic review or meta-analysis

No fault vaccine injury compensation after COVID-19: A systematic literature review and proposed typology.

Human vaccines & immunotherapeutics · 2026 · PMID 41630128

The COVID-19 pandemic brought about a unique and rapid period of global vaccine innovation. It revealed structural challenges not only in global vaccine affordability and distribution but in the liability and indemnity structures that can both impede access and affect fair outcomes for the small number of people who suffer severe side effects. This review examines vaccine injury and compensation mechanisms, including no-fault compensation schemes, aimed at addressing both the liability and indemnity concerns of dev…

Rank99.9
Randomized controlled trial

A process evaluation of a randomized clinical trial of selective decontamination of the digestive tract in ventilated adults admitted to intensive care: the SuDDICU PE study.

Trials · 2026 · PMID 42642777

BACKGROUND: The SuDDICU trial evaluated the effectiveness of selective digestive decontamination (SDD), a prophylactic antibiotic regimen comprising oral, gastric and intravenous (IV) components in ventilated adults admitted to intensive care. The trial recruited 9289 participants in 26 clusters across Australia and Canada. There was no difference in the primary outcome of in-hospital mortality, but a reduction in new positive blood cultures and antibiotic organisms. We conducted a concomitant process evaluation in…

Rank99.5
Randomized controlled trialResult signal: null

Ensitrelvir for the Treatment of Hospitalized Adults With COVID-19: An International Phase 3 Randomized Placebo-controlled Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 42017206

BACKGROUND: Antivirals remain an important treatment strategy for persons who experience severe and life-threatening COVID-19. Ensitrelvir is an oral 3CL protease inhibitor with potent antiviral activity. METHODS: We conducted an international randomized, placebo-controlled trial of ensitrelvir with standard of care (SOC) among adults hospitalized for COVID-19. The primary outcome was clinical recovery assessed by the days to recovery scale through day 60 (DRS-60), analyzed using a Van Elteren test. RESULTS: From 2…

Rank98.6
Randomized controlled trial

Immunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

Vaccine · 2026 · PMID 42531981

A multicomponent vaccine targeting seasonal influenza and coronavirus disease 2019 (COVID-19) may reduce disease burden by providing simultaneous protection in a single injection. We report findings from Part 1 (Japan) of a phase 3, Asia-Pacific, randomized, observer-blind study evaluating immunogenicity, reactogenicity, and safety of mRNA-based multicomponent vaccine mRNA-1083, combining influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens. Participants aged ≥50 years were randomized…

Rank98.1
Randomized controlled trial

Montessori approaches counterbalance pandemic precautions in nursing homes: staff perspectives.

The Gerontologist · 2026 · PMID 41849432

BACKGROUND AND OBJECTIVES: We describe nursing home staff perspectives implementing Montessori approaches to person-centered care (MAP-VA) in Veterans Administration Community Living Centers (CLCs) during the coronavirus disease 2019 (COVID-19) pandemic We investigated. staff perspectives on implementing MAP-VA to promote resident autonomy, engagement, and connection in the context of pandemic-related safety precautions. RESEARCH DESIGN AND METHODS: We used longitudinal data from a stepped-wedge, randomized clinica…

Rank97.9
Randomized controlled trial

Real-world effectiveness and safety of protein-based and mRNA COVID-19 vaccines (BEEHIVE trial).

Vaccine · 2026 · PMID 42486052

BACKGROUND: Real-world vaccine effectiveness (VE) and relative VE (rVE) data of protein-based and mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infections inform policy recommendations and reinforce public confidence. The study aim was to assess the safety and VE of the 2023-2024 protein-based and mRNA COVID-19 vaccines (XBB.1.5) in a real-world setting. METHODS: The single-site, pragmatic BEEHIVE clinical trial was conducted among participants aged ≥18 years from the Salt Lake City, Utah, area, who had pre…

Rank97.9
Randomized controlled trial

Immunogenicity and reactogenicity of fractional vs. full booster doses of COVID-19 vaccines: A non-inferiority, randomized, double-blind, phase IV clinical trial in Pakistan.

Vaccine · 2026 · PMID 42480193

BACKGROUND: We evaluated the immunogenicity and safety of fractional doses of SARS-CoV-2 booster vaccines compared to full doses in adults aged 18-60 primed with full series of Sinovac, AZD1222, or Natural Infection in Sindh, Pakistan. METHODS: This observer-blind, randomized phase IV non-inferiority trial (Feb 2023-Jan 2024) evaluated one-third, half, or full doses of BNT162b2, or full-dose Sinovac, in 10 arms based on primary vaccination. Participants were followed for 6 months with blood samples and safety asses…

Rank97.6
Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.6
Randomized controlled trial

Doravirine/Islatravir (100/0.75 mg) Once-Daily Compared With Bictegravir/Emtricitabine/Tenofovir Alafenamide as Initial HIV-1 Treatment: 48-Week Results From a Phase 3, Randomized, Controlled, Double-Blind, Noninferiority Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40079835

BACKGROUND: Doravirine/islatravir is an investigational regimen that is being studied for human immunodeficiency virus type 1 (HIV-1) treatment. METHODS: In this phase 3, double-blind, double-dummy trial (ClinicalTrials.gov NCT04233879), previously untreated adults with HIV-1 were randomized (1:1) and stratified by HIV-1 RNA (≤/>100 000 copies/mL) and CD4 count (</≥200 cells/µL) to doravirine/islatravir (100/0.75 mg) or bictegravir/emtricitabine/tenofovir alafenamide (50/200/25 mg) orally once-daily (primary endpoi…

Rank97.5
Randomized controlled trial

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

Human vaccines & immunotherapeutics · 2026 · PMID 41627968

A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase 1/2 clinical trial. This stratified, observer-blinded study randomly assigned healthy adults (18-75 years) to receive mRNA-1073 (25-µg, 50-µg, or 100-µg) + placebo, mRNA-1…

Rank97.3
Randomized controlled trial

Safety and immunogenicity of an mRNA COVID-19 vaccine administered to adults: A phase 2, randomized, active-controlled trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42647564

We conducted a phase 2, randomized, active-controlled, observer-blind study (NCT05960097) among healthy adults ≥18 y of age who completed a primary COVID-19 mRNA vaccination series, with or without a booster, ≥3 months earlier. Participants were randomized (1:1:1:1:1) to either receive an investigational bivalent mRNA COVID-19 vaccine encoding ancestral D614G and Omicron BA.4-5 spike proteins (CV0701 mRNA vaccine) at one of three dose levels, an investigational monovalent mRNA COVID-19 vaccine encoding the Omicron …

Rank97.3
Randomized controlled trialResult signal: harm

Implementation of a Face-To-Face Vs Virtual Peer-Integrated Collaborative Care Intervention for Mental Health Treatment of Physical Trauma Survivors: A Qualitative Study of Lessons from the COVID-19 Pandemic.

Psychiatry · 2026 · PMID 41289309

OBJECTIVE: We assessed the impact of the COVID-19 pandemic on the implementation of a peer-integrated enhancement of integrated clinical care intervention to address the mental health needs of 450 patients undergoing treatment for a physical injury. METHODS: Qualitative data were collected by 7 clinician investigators of a randomized controlled trial acting as participant observers in a trauma care setting of a major U.S. metropolitan hospital and analyzed in collaboration with an external mixed methods specialist.…

Rank96.8
Randomized controlled trial

The Platform trial In COVID-19 priming and BOOsting (PICOBOO): The immunogenicity, reactogenicity and safety of seven licensed COVID-19 vaccines delivered as fifth dose or subsequent boosters in immunocompetent adults.

Vaccine · 2026 · PMID 42520645

BACKGROUND: PICOBOO is a randomised, adaptive trial evaluating the immunogenicity and reactogenicity of licensed COVID-19 booster vaccines in immunocompetent individuals >12 years old. Here, we present data for seven different vaccines among three pre-specified participant strata defined by age and primary vaccine schedule: those primed with AZD1222 and aged 50 - < 70 or 70+ years old and those primed with BNT162b2 aged 50- < 70 years old until day (D) 365. METHODS: People who had not received a booster vaccine in …

Rank96.0
Systematic review or meta-analysis

Determinants of the Seasonal Influenza Vaccination Uptake Among People Aged 50 Years or Above During and After the Pandemic: A Systematic Review.

Vaccines · 2026 · PMID 42646722

Background/Objectives: Seasonal influenza vaccination (SIV) coverage remains suboptimal among adults aged ≥50 years, and the COVID-19 pandemic might influence the determinants of SIV uptake. This systematic review aimed to identify determinants of SIV uptake among adults aged ≥50 years during and after the COVID-19 pandemic. Methods: We searched PubMed, MEDLINE, Embase, Web of Science, Global Health, CINAHL, Cochrane Library, APA PsycINFO, and APA PsycArticles for studies published between 1 December 2019 and 1 Jan…

Rank96.0
Systematic review or meta-analysisResult signal: harm

Seroconversion Rates Following COVID-19 Vaccination in People Living with HIV: A Systematic Review and Meta-Analysis.

Vaccines · 2026 · PMID 42646667

Background: People living with human immunodeficiency virus (HIV) (PLWH) remain at increased risk of severe COVID-19 outcomes; however, conflicting evidence exists regarding the seroconversion rates of COVID-19 vaccines in this population. Methods: A systematic review and meta-analysis were conducted on studies reporting seroconversion outcomes following COVID-19 vaccination in PLWH. Results: Forty-four studies (5391 PLWH) were included in the meta-analysis. The overall pooled seroconversion proportion was 93.5%. B…

Rank96.0
Systematic review or meta-analysis

Comparator-Dependent Safety Signals for Incident Systemic Autoimmune Rheumatic Diseases After mRNA COVID-19 Vaccination: A Systematic Review.

Vaccines · 2026 · PMID 42646723

BACKGROUND: Pharmacovigilance systems have flagged possible associations between mRNA COVID-19 vaccination and systemic autoimmune inflammatory rheumatic diseases (AIRDs), generating uncertainty for rheumatologists counselling patients. As the first population-scale deployment of an mRNA vaccine platform, COVID-19 vaccination provides a unique setting to examine whether autoimmune safety signals detected in spontaneous reporting systems correspond to measurable disease risk. We synthesised pharmacovigilance and pop…

Rank95.8
Randomized controlled trial

New in Town-An internet-based self-efficacy intervention for internal migrants: A randomized controlled trial.

PloS one · 2024 · PMID 38452136

OBJECTIVE: Migration is a profound life transition that may threaten migrants' well-being and mental health. Results of several studies suggest that social self-efficacy beliefs may be beneficial for the psychological adjustment of migrants, buffering the effect of specific stressors related to migration, helping them reduce anxiety levels, and providing support in forming of new social bonds and better integration with a new community or culture. The primary purpose of this randomized controlled trial was to exami…

Rank95.0
Randomized controlled trial

A prematurely terminated phase 2, randomised trial to evaluate immunogenicity and reactogenicity of a single versus two-dose primary vaccination regimen of the mRNA vaccine BNT162b2 in previously SARS-CoV-2 infected children 5-11 years old (CoVacc trial).

Vaccine · 2026 · PMID 42364277

BACKGROUND: This open-label randomised phase 2 study aimed to determine whether a single versus two-dose BNT162b2 primary vaccination regimen in children 5 to 11 years old with prior SARS-CoV-2 infection was non-inferior in terms of immunogenicity and superior in terms of safety and reactogenicity. METHODS: Participants were randomly assigned (1:1) to receive either one or two doses, spaced 3 to 12-weeks. The primary endpoint was geometric mean ratio (GMR) of neutralizing antibodies against wild-type SARS-CoV-2 at …

Rank94.6
Randomized controlled trial

Immunological effects of supervised exercise in long COVID in adults: A secondary analysis of a randomized crossover trial.

Physiological reports · 2026 · PMID 42665974

Long COVID (post-acute sequelae of SARS-CoV-2 infection) affects approximately 5%-30% of survivors and is characterized by persistent fatigue, dyspnea, exercise intolerance, and cognitive impairment. We evaluated the immunological effects of supervised exercise in adults with long COVID. In this pre-specified exploratory substudy of the EXER-COVID randomized 2 × 2 crossover trial, participants completed a 6-week supervised exercise program (twice weekly) or usual care before crossing over after a 3-5 day washout. P…

Treatments That Failed Clinical Trials62 records
Rank101.3
Randomized controlled trialResult signal: harm

Adenovirus type 5 vector-based COVID-19 vaccine does not increase the likelihood of HIV infection.

Vaccine · 2026 · PMID 41785679

BACKGROUND: There is a concern about the potential increased risk of acquiring HIV infection after vaccination with adenovirus type 5 (Ad5) vector-based vaccines. We aimed to investigate whether Ad5-nCoV increases the risk of HIV infection. METHODS: Between September 2020 and March 2021, a Phase 3 clinical trial was executed to evaluate the efficacy of Ad5-nCoV. This trial, employing a double-blind, randomized, and placebo-controlled design, enrolled 44,247 participants from 66 clinical sites spanning Argentina, Ch…

Rank101.2
Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

BACKGROUND: The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we developed…

Rank99.3
Randomized controlled trialResult signal: null

Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial.

Implementation science : IS · 2026 · PMID 42098760

BACKGROUND: "Nudges" embedded in the electronic health record (EHR) facilitate desired decisions while preserving autonomy and may provide a scalable strategy to overcome the common implementation barrier of lack of knowledge about a best practice. We sought to test whether EHR-based nudges targeting two intensive care unit (ICU) clinician groups would safely increase evidence-based use of low tidal volume ventilation. METHODS: We performed a stepped-wedge, cluster randomized, hybrid type 3 effectiveness-implementa…

Rank99.2
Randomized controlled trial

Optimising COVID-19 episode identification using serology and PCR/rapid antigen testing: insights from the BRACE trial.

BMC infectious diseases · 2026 · PMID 41947067

BACKGROUND: Accurately identifying COVID-19 episodes was crucial during the pandemic for evaluating interventions. Results from diagnostic tools like PCR, rapid antigen test (RAT) and serology are affected by factors such as timing of tests and vaccination status. The BRACE trial developed an algorithm integrating these diagnostic tools for illness episode classification. METHODS: In the BRACE trial, 3988 participants reported 5512 febrile/respiratory illness episodes and provided longitudinal blood samples over on…

Rank99.0
Randomized controlled trialResult signal: null

Personal household air pollution exposure and SARS-CoV-2 antibody responses among women and infants: an analysis within the HAPIN trial.

Environment international · 2026 · PMID 41875666

BACKGROUND: While extensive research has linked ambient air pollution to increased COVID-19 infection rates and severity, the role of household air pollution-a major public health exposure affecting nearly 3 billion people globally-remains understudied. Here, we evaluate associations between a clean cooking intervention, personal household air pollution exposure, and serologic evidence of prior SARS-CoV-2 infection using exploratory intention-to-treat and exposure-response analyses. METHODS: The Household Air Pollu…

Rank98.6
Randomized controlled trialResult signal: null

Impact of eccentric exercise on walking functional capacity after severe COVID-19: randomized, controlled open-label trial.

Annals of physical and rehabilitation medicine · 2026 · PMID 42019312

INTRODUCTION: Severe COVID-19 infection leads to profound pulmonary, cardiovascular, and neuromuscular impairments, resulting in marked exercise deconditioning and reduced functional walking capacity after hospital discharge. Eccentric cycling offers high mechanical load with low metabolic cost and may therefore represent a relevant rehabilitation strategy to restore functional capacity in people after COVID-19. AIM: To compare functional recovery after 8 weeks of eccentric (ECC) or concentric (CON) training in ind…

Rank98.4
Randomized controlled trial

A pragmatic randomized controlled trial of self-directed online writing interventions for posttraumatic stress symptoms in a real-world digital setting.

European journal of psychotraumatology · 2026 · PMID 42635256

Background: Public health and other large-scale crises, such as the COVID-19 pandemic, have intensified the global mental health burden, creating unprecedented demand for accessible interventions for posttraumatic stress symptoms (PTSS).Objective: We evaluated the feasibility and effectiveness of two self-directed online writing interventions embedded within China's WeChat ecosystem during the COVID-19 pandemic through a pragmatic randomised controlled trial.Methods: Between December 2021 and August 2022, 1,526 adu…

Rank98.0
Randomized controlled trial

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42370465

BACKGROUND: Despite the relative success of immuno-modulatory disease-modifying therapy in relapsing remitting multiple sclerosis, progressive worsening of disability remains a major problem, particularly for those with secondary progressive multiple sclerosis. Various underlying mechanisms are likely to contribute, augmented by comorbidities (such as vascular risk) and ageing. In the phase 2b MS-STAT trial, simvastatin (80 mg) (Sandoz Ltd, Camberley, UK) reduced the mean annualised whole brain atrophy rate by 43% …

Rank98.0
Randomized controlled trial

Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts.

The New England journal of medicine · 2026 · PMID 42127390

BACKGROUND: Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 (Covid-19). Previously, no antiviral agents were approved for postexposure prophylaxis in household contacts of patients with Covid-19. METHODS: In this double-blind, randomized, placebo-controlled trial, we randomly assigned persons who were SARS-CoV-2-negative on local diagnostic testing but were household c…

Rank97.8
Randomized controlled trialResult signal: harm

Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.

Social psychiatry and psychiatric epidemiology · 2026 · PMID 39251412

BACKGROUND: Social participation as a protective factor against cognitive decline was one of the targets in the AgeWell.de study, a multi-domain interventional trial in a sample of older adults at increased risk for dementia. This study aimed to examine differential effects of the intervention and other influencing factors on social participation throughout the trial. METHODS: A longitudinal analysis of study data at the primary follow-up after 24 months (n = 819) was conducted. The Lubben Social Network Scale (LSN…

Rank97.6
Randomized controlled trialResult signal: null

Evaluating the effectiveness of a telemedicine-based STEADI implementation in primary care on fall outcomes: the STEADI options randomized controlled trial.

The Gerontologist · 2026 · PMID 41349283

BACKGROUND AND OBJECTIVES: Falls are a leading cause of injury and death among older adults (65 years and above). The Centers for Disease Control and Prevention's Stopping Elderly Accident, Deaths, and Injuries (STEADI) initiative aims to reduce falls by screening to find at-risk individuals, evaluation, and then addressing modifiable risk factors. This study evaluated the effectiveness of implementing a STEADI-based multi-component fall prevention approach via telemedicine in primary care. RESEARCH DESIGN AND METH…

Rank97.3
Randomized controlled trialResult signal: null

Assessing a facilitated social network intervention for health outcomes in lonely and socially isolated people: the pragmatic, cluster-randomized PALS trial.

Frontiers in public health · 2026 · PMID 41982893

INTRODUCTION: Loneliness has received attention in recent years as an important public health issue due to its associations with poorer mental and physical health. This study aimed to assess the effectiveness and cost-effectiveness of a facilitated social network intervention to alleviate loneliness and social isolation in community settings. METHODS: A pragmatic, cluster-randomized controlled trial (RCT) was conducted to compare participants receiving the intervention with a wait-list control group. This trial als…

Rank97.2
Randomized controlled trialResult signal: benefit

Effects of inspiratory muscle training on exercise capacity, muscle oxygenation and strength, physical activity, and dyspnea in patients with post-COVID-19 syndrome and pulmonary involvement: a randomized controlled triple-blinded study.

BMC pulmonary medicine · 2026 · PMID 41906071

BACKGROUND: Coronavirus disease 2019 (COVID-19) affects multiple organ systems, particularly the lungs, where hypoxemia may occur. Musculoskeletal problems, fatigue, and exercise intolerance frequently occur. The effects of inspiratory muscle strength training (IMST) have not been adequately investigated in patients with post-COVID-19. This study aimed to investigate the effects of IMST on functional exercise capacity, muscle oxygenation and strength, fatigue, and dyspnea in patients with post-COVID-19 syndrome and…

Rank97.2
Randomized controlled trialResult signal: null

Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42153520

BACKGROUND: HomeHealth is a home-based, voluntary sector service supporting older people with mild frailty to maintain independence through behaviour change. Support workers discuss the person's priorities and enable setting/achieving goals around mobility, nutrition, socialising and/or psychological well-being. AIMS: We tested clinical and cost-effectiveness of HomeHealth for maintaining independence in older people with mild frailty in a randomised controlled trial. METHODS: Design: Single-blind, parallel randomi…

Rank97.2
Randomized controlled trial

The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.

Annals of internal medicine · 2026 · PMID 41911553

BACKGROUND: Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom. OBJECTIVE: To assess the efficacy of fluvoxamine and metformin for long COVID fatigue. DESIGN: Randomized, placebo-controlled, adaptive trial. (ClinicalTrials.gov: NCT06128967). SETTING: Outpatient sites in Brazil. PARTICIPANTS: 399 adults with fatigue persisting 90 or more days after confirmed SARS-CoV-2 infection. INTERVENTION: Participants were randomly ass…

Rank96.9
Randomized controlled trial

Recruitment of nursing homes and residents in a cluster-randomised controlled trial to improve oral health (MundZaRR): a structured analysis of trials and tribulations.

Trials · 2026 · PMID 41827070

BACKGROUND: The cluster-randomised controlled MundZaRR trial aimed to improve the oral health of nursing home (NH) residents through a complex intervention programme. Recruitment in NH settings is notably challenging. Since there is only a limited number of reports from comparable studies on recruitment, we aimed to analyse the challenges and barriers related to the recruitment process of MundZaRR. METHODS: NHs in Southwestern Germany were recruited by the study team, and residents via NH contact persons, e.g. NH m…

Rank96.9
Randomized controlled trialResult signal: null

A randomized controlled trial testing a digital intervention to promote weight loss and weight loss maintenance.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026 · PMID 41989407

OBJECTIVE: This study aimed to determine the effectiveness and cost-effectiveness of the Choosing Health program, which tailors support to an individual's weight loss and weight loss maintenance determinants among adults with overweight and obesity. METHOD: We conducted a randomized controlled trial with a nested interrupted time series within-person design. Participants (N = 288) were randomized to the Choosing Health digital intervention (n = 145) or a control group (n = 143). Intervention participants completed …

Rank96.9
Randomized controlled trial

Evaluating a Tailored Web-Based eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic: Randomized Clinical Trial.

Journal of medical Internet research · 2026 · PMID 42430132

BACKGROUND: Prostate cancer (PCa) is the most common nonskin cancer among men. Although treatments achieve excellent survival for localized PCa, long-lasting complications significantly diminish patients' quality of life (QOL) across physical, sexual, psychosocial, and general symptom domains. Because these effects also profoundly impact intimate partners, often reducing partners' QOL as much as or more than patients' QOL, supportive care must address the needs of both members of the couple. OBJECTIVE: This study e…

Rank96.9
Randomized controlled trialResult signal: null

Dexmedetomidine for sedation during noninvasive ventilation in COVID-19 patients from the Helmet-COVID randomized clinical trial post-hoc analysis.

Scientific reports · 2026 · PMID 42103809

Dexmedetomidine may be used in patients managed by noninvasive ventilation (NIV), but its associations with intubation, mortality and health-related quality of life (HRQoL) are unclear. Thus, we aimed to assess the use of dexmedetomidine in patients with COVID-19-induced acute hypoxemic respiratory failure requiring NIV and its associations with the 28-day intubation rate, 28- and 180-day mortality rate, and HRQoL. This post-hoc study of the Helmet-COVID trial analyzed data from NIV-managed patients who did and did…

Rank96.8
Randomized controlled trialResult signal: null

The WORKWELL programme: a randomized controlled trial of job retention vocational rehabilitation for people with inflammatory arthritis.

Rheumatology (Oxford, England) · 2026 · PMID 42467833

OBJECTIVE: People with inflammatory arthritis (InfA) frequently experience work instability, absenteeism, and reduced productivity, culminating in early job loss. This study evaluated the effectiveness and cost-effectiveness of WORKWELL job retention vocational rehabilitation (JRVR) delivered by occupational therapists, compared with a control group receiving written self-help advice. METHODS: A pragmatic, multicentre randomized controlled trial was conducted across 18 UK National Health Service (NHS) Trusts. Emplo…

Rank96.7
Randomized controlled trialResult signal: null

Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 · PMID 41429349

OBJECTIVES: To report long-term clinical efficacy, safety, pharmacokinetics, immunogenicity and seroneutralization results of AZD7442 (monoclonal antibodies tixagevimab-cilgavimab) in patients hospitalized with COVID-19. METHODS: In this phase 3, double-blind, randomized, multicentre trial, hospitalized adults with PCR-confirmed SARS-CoV-2 infection were randomly assigned 1:1 to receive AZD7442 or placebo, and followed-up until day 456, with repeated blood sample collections until day 365. Clinical endpoints includ…

Rank96.6
Randomized controlled trialResult signal: null

A randomized controlled trial of adjunctive speleotherapy in asthma, COPD and long COVID.

Scientific reports · 2026 · PMID 42173973

Speleotherapy (underground climate therapy) is a non-pharmacological intervention for chronic respiratory diseases. This randomized controlled trial investigated whether a 3-week speleotherapy course (6 sessions, 2 h/week) improves respiratory outcomes in patients on standard background therapy with asthma, COPD, or Long COVID, and whether it affects blood CO2 levels. The control group did not receive speleotherapy but continued their standard therapy. A total of 208 patients (asthma: n = 107; COPD: n = 59; Long CO…

Rank96.4
Randomized controlled trialResult signal: null

Can An Innovative Physical Therapy Program Enhance Mobility in Middle-Aged and Older Veterans With Slow Walking Speed? A Randomized Controlled Trial.

Archives of physical medicine and rehabilitation · 2026 · PMID 41397627

OBJECTIVE: To investigate the efficacy of an innovative physical therapy program targeting mobility. DESIGN: Single-blinded randomized controlled trial. SETTING: Outpatient care VA regional tertiary care center. PARTICIPANTS: Community-dwelling middle-aged and older Veterans (N=150) with slow walking speed. INTERVENTIONS: Live Long Walk Strong (LLWS) is an 8-week, 10 (1-h/session) session outpatient physical therapy program. It was designed to enhance mobility by targeting impairments linked to mobility decline. It…

Rank96.4
Randomized controlled trial

Health-related quality of life in immunocompromised adults with mild-moderate COVID-19 treated with nirmatrelvir-ritonavir: results from the randomized, double-blinded EPIC-IC trial.

Health and quality of life outcomes · 2026 · PMID 41857593

BACKGROUND: Little is known about health-related quality of life (HRQoL) in immunocompromised people during and after COVID-19 illness. We describe HRQoL outcomes from the EPIC-IC trial, which included participants with immunocompromise and mild–moderate COVID-19. METHODS: EPIC-IC was a randomized, double-blind trial. Participants were assigned 1:1:1 to 5-day, 10-day, or 15-day nirmatrelvir-ritonavir (NMV/r) and completed the SF-36 and EQ-5D-5L through Week (W)24. HRQoL was analyzed across and by treatment arms for…

Rank96.2
Randomized controlled trial

Center- vs Home-Based Cardiac Rehabilitation in Patients With Heart Failure: EXIT-HF Randomized Controlled Trial.

JACC. Heart failure · 2025 · PMID 39895436

BACKGROUND: Despite being an evidence-based intervention, the implementation of cardiac rehabilitation (CR) is often unsatisfactory, especially among patients with heart failure (HF). Home-based CR can serve as an alternative to improve accessibility for patients unable to participate in center-based programs. OBJECTIVES: The study sought to compare the clinical impact of center- vs home-based CR in HF patients. METHODS: Single-center, parallel group, noninferiority trial, enrolling HF patients irrespective of ejec…

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Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.