Viral infections evidence library

COVID-19

A living PubMed evidence library for SARS-CoV-2 prevention, acute COVID-19 treatment, severe disease, post-COVID conditions, and emerging variants.

PubMed only Research ranked Conflicts shown Data downloadable

Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 607 non-retracted PubMed-indexed records for COVID-19. The structured collection includes 7 guideline or consensus records, 97 evidence syntheses/systematic reviews/meta-analyses, and 114 randomized or phase III studies. 60 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 470 of 607 included records.

Engine 0.3.2 Snapshot v8 Updated 2026-09-14 Download source data · CSV

PubMed records607Non-retracted records included

Last 24 months60Records found by the recent-research search

High-priority evidence211Syntheses, reviews, randomized and phase III studies

Effect estimates204Machine-readable values extracted from abstracts

COI statements77.4%Coverage within PubMed records

Funding records95PMIDs with grant/funding metadata

Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years

2020

2021

2022

2023

2024

2025

545

2026

2027

Evidence composition

Study designs

Other or unclassified257

Randomized trials109

Meta-analyses62

Preclinical/laboratory53

Systematic reviews35

Prospective cohorts30

Cohort studies18

Observational studies14

Clinical guidelines7

Phase II trials6

Transparency

Conflict-of-interest reporting

COI statement present238

Reported no conflicts175

Not reported in PubMed record137

Declared financial/industry relationship57

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract541

Neutral/null signal40

Harm signal18

Supportive signal5

Mixed signal3

Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0

0.250.51.02.04.0

not_reported Odds Ratio · PMID 41429349 · 2026

0.93

not_reported Odds Ratio · PMID 41429349 · 2026

2.04

not_reported Odds Ratio · PMID 41429349 · 2026

1.78

not_reported Odds Ratio · PMID 41429349 · 2026

2.02

not_reported Odds Ratio · PMID 41496460 · 2026

5.45 95% CI 4.43–6.71

not_reported Odds Ratio · PMID 41496460 · 2026

7.71 95% CI 5.97–9.96

not_reported Odds Ratio · PMID 41496460 · 2026

5.32 95% CI 4.84–5.85

mortality Odds Ratio · PMID 41504189 · 2026

4.66

mortality Odds Ratio · PMID 41504189 · 2026

3.34

not_reported Odds Ratio · PMID 41571287 · 2026

1.19 95% CI 0.70–2.01

not_reported Odds Ratio · PMID 41571287 · 2026

5.48 95% CI 0.70–43.09

response Odds Ratio · PMID 41571287 · 2026

0.40 95% CI 0.17–0.97

response Odds Ratio · PMID 41571287 · 2026

0.43 95% CI 0.18–1.06

response Odds Ratio · PMID 41571287 · 2026

0.15 95% CI 0.04–0.54

View extracted numerical results 60

Publication	Outcome	Measure	Reported value	Source
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026	not_reported	Odds Ratio	0.93	PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026	not_reported	Odds Ratio	2.04	PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026	not_reported	Odds Ratio	1.78	PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026	not_reported	Odds Ratio	2.02	PMID 41429349
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026	not_reported	Odds Ratio	5.45 95% CI 4.43–6.71	PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026	not_reported	Odds Ratio	7.71 95% CI 5.97–9.96	PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026	not_reported	Odds Ratio	5.32 95% CI 4.84–5.85	PMID 41496460
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026	mortality	Odds Ratio	4.66	PMID 41504189
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026	mortality	Odds Ratio	3.34	PMID 41504189
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	1.19 95% CI 0.7–2.01	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	5.48 95% CI 0.7–43.09	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.4 95% CI 0.17–0.97	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.43 95% CI 0.18–1.06	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.15 95% CI 0.04–0.54	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.12 95% CI 0.03–0.47	PMID 41571287
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	100.0	PMID 41627968
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026	adverse events	Odds Ratio	2.0	PMID 41627968
The role of age, sex, and ethnicity in vaccine trust, and sources of information in Canada: Findings from a national survey.Human vaccines & immunotherapeutics · 2026	not_reported	Percentage Comparison	87.0percent vs 83.0percent	PMID 41640305
Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026	not_reported	Odds Ratio	0.75 p = .036	PMID 42420160
Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	25.0	PMID 42268674
Associations between maternal lipid metabolism in early pregnancy and postpartum symptoms of depression and anxiety: results from a longitudinal cohort of 266 women.Journal of psychiatric research · 2026	not_reported	Odds Ratio	1.65 95% CI 1.22–2.1	PMID 42497820
Low prevalence of bacterial coinfection at hospital admission in COVID-19 and the role of procalcitonin as a rule-out biomarker.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026	mortality	Odds Ratio	28.0	PMID 42349772
Low prevalence of bacterial coinfection at hospital admission in COVID-19 and the role of procalcitonin as a rule-out biomarker.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026	not_reported	Odds Ratio	4.31 95% CI 2.35–7.84	PMID 42349772
Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.Journal of affective disorders · 2026	not_reported	Odds Ratio	0.72	PMID 42203050
Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.Journal of affective disorders · 2026	not_reported	Odds Ratio	0.69	PMID 42203050
Neonatal intensive care unit admission among infants born full-term to CDC's COVID-19 Vaccine Pregnancy Registry participants: A matched cohort study.Human vaccines & immunotherapeutics · 2026	not_reported	Percentage Comparison	7.7percent vs 11.3percent	PMID 41774852
The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.Human vaccines & immunotherapeutics · 2026	hospitalization	Odds Ratio	5.5 95% CI 2.2–14.0	PMID 42246636
The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.Human vaccines & immunotherapeutics · 2026	hospitalization	Odds Ratio	3.9 95% CI 1.6–9.7	PMID 42246636
The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.Human vaccines & immunotherapeutics · 2026	hospitalization	Odds Ratio	9.3 95% CI 3.3–26.7	PMID 42246636
Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.Health technology assessment (Winchester, England) · 2026	not_reported	Odds Ratio	54.0	PMID 42370465
Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.Health technology assessment (Winchester, England) · 2026	not_reported	Hazard Ratio	1.13 95% CI 0.91–1.39 p = 0.263	PMID 42370465
Relationship between negative-pressure ICU rooms and the risk of COVID-19-associated pulmonary aspergillosis: an ancillary analysis of the COVID-ICU cohort study.Critical care (London, England) · 2026	not_reported	Hazard Ratio	0.45 95% CI 0.27–0.76 p = 0.002	PMID 42186034
Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.Social psychiatry and psychiatric epidemiology · 2026	not_reported	Odds Ratio	1.38	PMID 39251412
Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.Social psychiatry and psychiatric epidemiology · 2026	not_reported	Odds Ratio	0.84	PMID 39251412
A Cluster Randomized Trial of a Vaccination Communication Educational Intervention: Impact on COVID-19 Vaccine Uptake in Veterans.Journal of general internal medicine · 2026	not_reported	Odds Ratio	1.16 p = 0.28	PMID 41680545
The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study.Clinical physiology and functional imaging · 2026	not_reported	Odds Ratio	2.0 p = 0.97	PMID 41921975
The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study.Clinical physiology and functional imaging · 2026	not_reported	Percentage Comparison	9.8percent vs 16.1percent p = 0.97	PMID 41921975
Effectiveness of intensive community care services for adolescents with acute psychiatric emergencies: findings from a feasibility multi-centre, parallel-group, single-blinded RCT.Health technology assessment (Winchester, England) · 2026	not_reported	Hazard Ratio	1.34 95% CI 0.63–2.86	PMID 42148829
Effectiveness of intensive community care services for adolescents with acute psychiatric emergencies: findings from a feasibility multi-centre, parallel-group, single-blinded RCT.Health technology assessment (Winchester, England) · 2026	not_reported	Odds Ratio	3.66 95% CI 1.65–8.13	PMID 42148829
[Practice variation in Medical Decision in Critically Ill Patients During COVID-19 Pandemic in Spain].Journal of healthcare quality research · 2026	not_reported	Odds Ratio	8.13	PMID 42235285

Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage77.4%137 records have no COI statement exposed in PubMed.

Funding metadata coverage15.7%Coverage indicates whether grant/funding metadata was present, not independence or study quality.

Most frequently reported funding agencies

NIAID NIH HHS28

NHLBI NIH HHS10

Wellcome Trust9

NIDDK NIH HHS9

National Natural Science Foundation of China7

NIH HHS6

NIGMS NIH HHS6

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior6

View records with declared financial or industry relationships 12

A systematic review of observational studies of sodium-glucose cotransporter 2 inhibitors and COVID-19 outcomes: a methodological assessment.

Declaration of competing interest In the last three years, Dr. Suissa attended scientific advisory meetings for Atara, Novartis, and Panalgo, and received speaking fees from Amgen, Covis Pharma, and CSL Behring. Dr. Filion received personal fees from Regeneron and Statlog, both unrelated to this study. The remaining authors have no relevant conflicts of interest to disclose.

PMID 42203176 · 2026

Clinical practice guideline for long COVID prevention and treatment.

Conflict of interest: B. Cao is a member of the European Respiratory Journal editorial board. J.B. Soriano reports grants from Linde via Hospital Universitario de La Princesa, consultancy fees from ERS and SEPAR, participation in speaking activities, advisory committees and consultancies for Air Liquide, Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, ERS, Grifols, GSK, Linde, Lipopharma, Mundipharma, Novartis, Pfizer, RiRL, Rovi, SEPAR and Takeda, a leadership role for the Spanish Network of Research in Long COVID (REiCOP), and is an Associate Editor for the European Respiratory Journal. R. Paredes reports participation in an advisory board with Pfizer, Gilead and AstraZeneca. R.A. Evans reports grants from Genentech/Roche, lecture fees from Moderna, and fees for participation on an advisory board for the UK National COVID Inquiry. M.J. Peluso reports consultancy fees from Gilead Sciences and AstraZeneca. J.D. Chalmers reports grants or contracts from AstraZeneca, Chiesi, Genentech, Gilead Sciences, GlaxoSmithKline, Insmed, Grifols, Trudell, Verona and Boehringer Ingelheim, and consulting fees from AstraZeneca, Biomx, Chiesi, CSL Behring, Expedition, GlaxoSmithKline, Insmed, Grifols, Boehringer Ingelheim, Pfizer, Sanofi/Regeneron and Zambon, and is the Chief Editor of the European Respiratory Journal. Y. Chen is the co-founder and co-chair of the RIGHT (Reporting Items for Practice Guidelines in Healthcare) working group. The remaining authors have no potential conflicts of interest to disclose.

PMID 41856572 · 2026

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Vivek Shinde, Wayne Woo, Susan Neal, Joyce S. Plested, Mingzhu Zhu, Shane Cloney-Clark, Iksung Cho, and Raburn M. Mallory are employees of Novavax, Inc. and may hold Novavax, Inc. stock. Anthony M. Marchese, Timothy S. Vincent, Louis Fries, and Greg Glenn are former employees of Novavax, Inc. and may hold Novavax, Inc. stock.

PMID 42390526 · 2026

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

JML and SAH’s institution received funding for the conduct of clinical trials from VIDO, Moderna, Pfizer and VBI. The remaining authors have no conflicts to declare.

PMID 42268674 · 2026

Immune correlates analysis in NextCOVE trial for a next-generation mRNA-1283 COVID-19 vaccine.

CM, JF, RW, SC, DE, BG, RD, HZ, and LZ are employees of Moderna, Inc., and may hold stock/stock options in the company.

PMID 42220116 · 2026

Effect of nipocalimab on IgG responses to vaccinations and viral infections in patients with IgG autoantibody-mediated diseases: Post hoc analyses of three randomized, placebo-controlled trials.

FY, EM, BN, CBM, MC, KF, QW, JJH, KC, SR, RRC, RE, CC, MJL, DD, and SG are employees of Johnson & Johnson and may hold stock options in Johnson & Johnson. PCT has served on Data and Safety Monitoring Boards for Immunovant, Sanofi, and MoonLake; served as a consultant for AbbVie, Alfasigma, Aqtual, Biogen, Eli Lilly, Fresenius, Gilead Sciences, Janssen, Nordic Pharma, Roche, Takeda, and UCB; and received grants/research support from Alfasigma. J-EG has served as a consultant for AbbVie, Bristol Myers Squibb, Galapagos, Gilead Sciences, Johnson & Johnson, Eli Lilly, MSD, Novartis, Pfizer, Sanofi, and UCB. GN has served as a consultant for Johnson & Johnson, Novartis, argenx, and Amgen; received research or grant support related to SjD and systemic lupus erythematosus from LuCIN network, Novartis, Janssen, Amgen, Bristol Myers Squibb, Pfizer, Sanofi, and Horizon. TV has received research or grant support related to myasthenia gravis from Alexion, AstraZeneca Rare Disease, Amgen, argenx, Cartesian Therapeutics, COUR, Dianthus Therapeutics, Immunovant, Johnson & Johnson, NMD Pharma, Regeneron, and UCB; and served as a consultant or on a speakers bureau for Alexion, AstraZeneca Rare Disease, Amgen, argenx, CSL Behring, Dianthus Therapeutics, Johnson & Johnson, and Takeda. CA received funding for travel, meeting attendance, and advisory board participation from Alexion, Momenta, Sanofi, argenx, UCB, and Johnosn & Johnson. KLW received consulting fees from AbbVie, AstraZeneca, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead, GSK, Moderna, Novartis, Roche, Sanofi, UCB, Zura Bio, Takeda, Ouro Medicines, and Otsuka.

PMID 42084498 · 2026

NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants.

Young reports personal fees from Astra-Zeneca, Gilead, Moderna, Pfizer and Sanofi outside the submitted work. Wang disclose that a patent (Patent No.: US 11,054,429 B1) was issued for the surrogate virus neutralisation test platform (cPass kit) used in this study, and declare royalty payment from GenScript for inventing the technology. All other authors no potential conflicts of interest.

PMID 42083894 · 2026

Exploring the experiences and perceptions of co-administration of routine vaccines in adults: Findings from an embedded qualitative study with participants and research delivery staff in the ZosterFluCov randomized controlled trial.

This work was funded by an investigator initiated grant from GSK. SR’s and VW’s time was funded by an investigator led grant from GSK. RL has received financial compensation from Sanofi for participating in a influenza vaccine advisory board in 2023 and from Astra Zeneca for a conference presentation in 2022. HS has previously received funding for investigator driven research from Moderna and funding to attend COVID-19 related advisor boards and to present at conferences from Pfizer.

PMID 41734040 · 2026

Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.

FN owns some AstraZeneca shares. FN and AS have research project support (paid to his institution, no personal fees) from Bayer, with no relation to the work reported here. All authors have completed the Unified Competing Interest form (available on request from the corresponding author) and declare: no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work.

PMID 41496460 · 2026

Safety of COVID-19 mRNA-1273 booster doses in Asian populations: A literature review of post-marketing observational studies.

All authors are employees of Moderna and may hold stock/stock options in the company: CC, AKB (Moderna, Australia); DE, VU (Moderna, Inc., USA); and PM (Moderna, Singapore).

PMID 42154963 · 2026

From discovery through emergency use to the present: Safety evaluation of the COVID-19 mRNA-1273 (Moderna) vaccine.

WS is an employee of Moderna, Inc., and may hold stock/stock options in the company.

PMID 42018766 · 2026

Hematologic adverse events following COVID-19 vaccination and revaccination in persons aged 12 and above: A Canadian Immunization Research Network study.

CB is a co-investigator on a project funded by Moderna but has not received any funding directly. AC has received research grants and support from Pfizer and GSK. AC has served on speaker bureaus and received honoraria from Pfizer, GSK, Moderna, and Sanofi. AC has also provided consulting services for Merck, GSK, Pfizer, Moderna, Innomed Pharma, and Paladin. LC’s research institution has received honoraria from Bayer, BMS-Pfizer Alliance, The Academy for Continued Advancement in Healthcare Education, Amag Pharmaceutical, LEO Pharma, Sanofi, Valeo Pharma, and Servier. LC holds a Tier 2 research Chair in Thrombosis and Anticoagulation Safety from the University of Ottawa. SS has received speaker honoraria from CSL Behring. MS has been an investigator on projects funded by GlaxoSmithKline, Merck, Moderna, Pfizer, and Sanofi-Pasteur. All funds have been paid to his institute, and he has not received any personal payments. MS is supported via a salary award from the BC Children’s Hospital Foundation. KAT has received grants to her institution from the Coalition for Epidemic Preparedness Innovations outside the submitted work. JMP’s institution has received funds from AstraZeneca for an industry-initiated study of children with RSV bronchiolitis and from Merck for an investigator-initiated study of children with pneumonia; he is also conducting a clinical trial that has received in-kind support for diagnostics from bioMe. JC received honoraria from GSK, Pfizer, AstraZeneca for consultancy work not related to this manuscript. JC holds a Tier 2 Research Chair in Immunization in People with Compromised Immunity from the University of Ottawa. AM has served on speaker bureaus and provided consulting services from Pfizer, Sanofi and Merck for work unrelated to this manuscript. All other authors do not have conflicts of interest to declare.

PMID 41848549 · 2026

Journal of human hypertension · 2026

Although numerous studies have investigated the association between hypertension and coronavirus disease 2019 (COVID-19) severity, differences in study characteristics have limited the consistency and generalizability of the available evidence. This systematic review and meta-analysis systematically evaluated the association between hypertension and COVID-19 severity by synthesizing evidence from 30 studies involving 15,549 participants comparing the prevalence of hypertension in non-severe and severe COVID-19 patients. Pooled odds ratios (ORs) were calculated using a random-effects model. Heterogeneity was assessed using I² and τ² statistics, while subgroup analyses and meta-regression exam…

PMID 42595776

Human vaccines & immunotherapeutics · PMID 42223472

Treatment Options Studied in the PubMed Collection

These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.

higher-confidence evidence

COVID-19 Vaccines

87 linked PMIDs367472 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization, recurrence, long COVID
Populations represented: general population; children; neutralizing antibody; severe COVID-19; older adults; severe COVID-19; older adults
Mechanism: Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2

PMID 39971395 PMID 41785679 PMID 42057741 PMID 41630128 PMID 42717339 PMID 42640841 PMID 37997650 PMID 36651093

higher-confidence evidence

COVID-19 vaccine

40 linked PMIDs232803 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization
Populations represented: general population; children; neutralizing antibody; severe COVID-19; older adults; older adults; severe COVID-19; immunocompromised patients; children
Mechanism: Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2 Primary objectives were to demonstrate noninferiority of mRNA-1083 versus comparators for influenza hemagglutination inhibition (HAI) responses and SARS-CoV-2 neutralizing antibody (nAb; PsVNA) responses at Day 29 after vaccination and to evaluate safety and reactogenicity of study vaccines

PMID 41785679 PMID 42057741 PMID 42640841 PMID 37997650 PMID 34171345 PMID 41680545 PMID 42383737 PMID 42430873

higher-confidence evidence

Antibodies, Viral

37 linked PMIDs90470 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality
Populations represented: general population; neutralizing antibody; children; severe COVID-19; older adults
Mechanism: Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions This validated pseudo-VSV based SARS-CoV-2 neutralization assay is a valuable bioassay for evaluating neutralizing antibody potency against various SARS-CoV-2 strains in a BSL-2 environment, thus making it useful for vaccine and therapeutic development

PMID 42536815 PMID 41785679 PMID 41947067 PMID 41875666 PMID 34260780 PMID 42084498 PMID 42361783 PMID 42184776

moderate-confidence evidence

Antiviral Agents

26 linked PMIDs17039 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality, mechanical ventilation, adverse events, serious adverse events, long COVID
Populations represented: general population; severe COVID-19; moderate COVID-19; neutralizing antibody; advanced; critical COVID-19
Mechanism: In our preliminary screening, vilazodone was identified as an inhibitor of SARS-CoV-2 replication via targeting the METTL3 protein However, its moderate binding to METTL3 and weak inhibitory activity suggest that its antiviral activity may be mediated through targets other than METTL3

PMID 39565561 PMID 42455170 PMID 42385347 PMID 42653958 PMID 42702742 PMID 42697889 PMID 42557548 PMID 42348940

limited evidence

Spike Glycoprotein, Coronavirus

23 linked PMIDs6832 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events
Populations represented: general population; neutralizing antibody; severe COVID-19; older adults; children
Mechanism: This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome The primary targets of SARS-CoV-2 are lung cells, where viral-host interactions trigger extensive molecular and structural changes

PMID 42361783 PMID 42361718 PMID 42287949 PMID 42302372 PMID 42620702 PMID 42702742 PMID 42554515 PMID 42448314

moderate-confidence evidence

Antibodies, Neutralizing

18 linked PMIDs54944 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality
Populations represented: general population; neutralizing antibody; severe COVID-19
Mechanism: This validated pseudo-VSV based SARS-CoV-2 neutralization assay is a valuable bioassay for evaluating neutralizing antibody potency against various SARS-CoV-2 strains in a BSL-2 environment, thus making it useful for vaccine and therapeutic development The receptor binding domain (RBD) of Spike is an appealing antigen due to its relatively simple structure, proven immunogenicity - especially in multimerized formats - and because it harbors most neutralizing antibody epitopes

PMID 41785679 PMID 42423335 PMID 42585813 PMID 42554515 PMID 42545256 PMID 42687061 PMID 42647564 PMID 42378814

limited evidence

spike protein, SARS-CoV-2

16 linked PMIDs5556 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events
Populations represented: general population; severe COVID-19; older adults
Mechanism: This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome This integrated, one-pot, and scalable platform provides a versatile strategy for fast, sensitive, and multimodal nucleic acid detection applicable to diverse targets

PMID 42361718 PMID 42330669 PMID 42287949 PMID 42620702 PMID 42554515 PMID 42448314 PMID 41605700 PMID 41362990

moderate-confidence evidence

Influenza Vaccines

15 linked PMIDs69688 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, mortality, serious adverse events, hospitalization
Populations represented: general population; neutralizing antibody; children; older adults; C-reactive protein; children; advanced
Mechanism: Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2 Primary objectives were to demonstrate noninferiority of mRNA-1083 versus comparators for influenza hemagglutination inhibition (HAI) responses and SARS-CoV-2 neutralizing antibody (nAb; PsVNA) responses at Day 29 after vaccination and to evaluate safety and reactogenicity of study vaccines

PMID 41734040 PMID 41686169 PMID 41627968 PMID 41661551 PMID 42213900 PMID 42053343 PMID 41884998 PMID 42246636

moderate-confidence evidence

BNT162 Vaccine

14 linked PMIDs139596 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, mortality, hospitalization, recurrence
Populations represented: general population; children; severe COVID-19; older adults; critical COVID-19
Mechanism: BACKGROUND: Using adapted COVID-19 vaccines targeting current variants in circulation is necessary for addressing the dynamic evolution of the SARS-CoV-2 virus and protecting against emerging variants RESEARCH DESIGN AND METHODS: Using a previously published, combined Markov-decision tree model adapted for Costa Rica, this study estimated the outcomes of different vaccination strategies with BNT162b2 COVID-19 mRNA vaccine, targeting various age and risk groups

PMID 42661284 PMID 42383737 PMID 42361783 PMID 42118165 PMID 42628376 PMID 42685055 PMID 42027105 PMID 41848549

higher-confidence evidence

Vaccines, Synthetic

13 linked PMIDs149740 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: adverse events, serious adverse events, reported clinical outcomes, mortality, hospitalization
Populations represented: general population; neutralizing antibody; severe COVID-19; older adults
Mechanism: Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2 Primary objectives were to demonstrate noninferiority of mRNA-1083 versus comparators for influenza hemagglutination inhibition (HAI) responses and SARS-CoV-2 neutralizing antibody (nAb; PsVNA) responses at Day 29 after vaccination and to evaluate safety and reactogenicity of study vaccines

PMID 41627968 PMID 42647564 PMID 42378814 PMID 42268674 PMID 42155675 PMID 42361783 PMID 42423335 PMID 42213900

moderate-confidence evidence

Immunoglobulin G

10 linked PMIDs5181 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events
Populations represented: general population; children
Mechanism: Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions

PMID 42699831 PMID 42084498 PMID 42361783 PMID 42184776 PMID 42118165 PMID 42585813 PMID 41605700 PMID 42378814

limited evidence

Biomarkers

9 linked PMIDs948 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, hospitalization, mortality, adverse events, serious adverse events
Populations represented: general population; severe COVID-19; older adults; D-dimer
Mechanism: Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome

PMID 42551562 PMID 41263641 PMID 42361718 PMID 42567273 PMID 42470742 PMID 41362990 PMID 41902764 PMID 42323884

moderate-confidence evidence

2019-nCoV Vaccine mRNA-1273

7 linked PMIDs10629 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: adverse events, mortality, hospitalization, serious adverse events, reported clinical outcomes
Populations represented: general population; severe COVID-19; severe COVID-19; older adults; critical COVID-19
Mechanism: While the original mRNA COVID-19 vaccine, mRNA-1273, targets the full-length SARS-CoV-2 spike protein, mRNA-1283 is a novel next-generation mRNA COVID-19 vaccine that specifically targets immunodominant domains within the spike protein

PMID 41627968 PMID 42154963 PMID 41764030 PMID 42018766 PMID 41744151 PMID 42594644 PMID 42220116

limited evidence

Coronavirus 3C Proteases

7 linked PMIDs1030 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events
Populations represented: general population; severe COVID-19; advanced
Mechanism: The organoselenium drug Ebselen has shown potent in vitro inhibition of Mpro as well as antiviral activity, granting clinical interest as a COVID-19 treatment option The combined results imply that the cephalosporin scaffold may be of use for development of antiviral drugs targeting the SARS-CoV-2 proteases and, by implication, other nucleophilic cysteine proteases

PMID 41481484 PMID 42269456 PMID 42235189 PMID 42102470 PMID 42647061 PMID 42127390 PMID 42314596

limited evidence

Protease Inhibitors

6 linked PMIDs— reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes
Populations represented: general population; advanced
Mechanism: The organoselenium drug Ebselen has shown potent in vitro inhibition of Mpro as well as antiviral activity, granting clinical interest as a COVID-19 treatment option The combined results imply that the cephalosporin scaffold may be of use for development of antiviral drugs targeting the SARS-CoV-2 proteases and, by implication, other nucleophilic cysteine proteases

PMID 42697889 PMID 41481484 PMID 42235189 PMID 42102470 PMID 42647061 PMID 42314596

preliminary evidence

RNA, Viral

6 linked PMIDs— reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality, hospitalization
Populations represented: general population; SARS-CoV-2 RNA
Mechanism: This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome The NeuMoDx™ assay demonstrated strong correlations between Ct values and viral RNA concentrations, with R² values of 0.9971 and 0.9952 for the N and Nsp2 targets, respectively

PMID 42361718 PMID 42309186 PMID 42594724 PMID 42322970 PMID 42247945 PMID 35004568

preliminary evidence

Pneumococcal Vaccines

5 linked PMIDs7506 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: mortality, hospitalization, reported clinical outcomes
Populations represented: general population; older adults; children
Mechanism: Not explicitly reported in the retrieved PubMed metadata or abstracts.

PMID 41914241 PMID 41816940 PMID 41665459 PMID 41686169 PMID 42300867

preclinical evidence only

3C-like proteinase, SARS-CoV-2

5 linked PMIDs1030 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events
Populations represented: general population; severe COVID-19
Mechanism: The organoselenium drug Ebselen has shown potent in vitro inhibition of Mpro as well as antiviral activity, granting clinical interest as a COVID-19 treatment option The combined results imply that the cephalosporin scaffold may be of use for development of antiviral drugs targeting the SARS-CoV-2 proteases and, by implication, other nucleophilic cysteine proteases

PMID 41481484 PMID 42235189 PMID 42102470 PMID 42647061 PMID 42127390

Conflicting Research

higher-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

65 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 61harm: 2null: 2

PMID 39971395 PMID 41785679 PMID 42057741 PMID 41630128 PMID 42220116 PMID 42717339 PMID 42640841 PMID 42390526 PMID 41627968 PMID 42647564

higher-confidence evidence

COVID-19 vaccine · multiple reported outcomes

28 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 25harm: 2null: 1

PMID 41785679 PMID 42057741 PMID 42220116 PMID 42640841 PMID 42647564 PMID 37997650 PMID 34171345 PMID 41680545 PMID 42383737 PMID 42430873

higher-confidence evidence

Antibodies, Viral · multiple reported outcomes

27 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 25harm: 1null: 1

PMID 42536815 PMID 41785679 PMID 42220116 PMID 41947067 PMID 41875666 PMID 42390526 PMID 41627968 PMID 42647564 PMID 34260780 PMID 42378814

higher-confidence evidence

Antiviral Agents · multiple reported outcomes

17 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

mixed: 1unknown: 15benefit: 1

PMID 40067859 PMID 34837230 PMID 39565561 PMID 42316440 PMID 42455170 PMID 42385347 PMID 42653958 PMID 42702742 PMID 42697889 PMID 42557548

higher-confidence evidence

Antibodies, Neutralizing · multiple reported outcomes

13 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 11harm: 1null: 1

PMID 41785679 PMID 42220116 PMID 42647564 PMID 42378814 PMID 36411267 PMID 41569047 PMID 42268674 PMID 42227026 PMID 42423335 PMID 42585813

moderate-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

9 studies

Status: apparently conflicting; different clinical questions. Population: children. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 6harm: 2null: 1

PMID 42364277 PMID 41911278 PMID 42053343 PMID 42685055 PMID 42223472 PMID 41814863 PMID 42667899 PMID 42535943 PMID 42027105

moderate-confidence evidence

remdesivir · multiple reported outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

mixed: 1unknown: 3

PMID 40067859 PMID 42316440 PMID 42455170 PMID 42385347

moderate-confidence evidence

Drug Combinations · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 1benefit: 1null: 1

PMID 34837230 PMID 36411267 PMID 42536986

moderate-confidence evidence

Adenosine Monophosphate · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

mixed: 1unknown: 2

PMID 40067859 PMID 42316440 PMID 42455170

moderate-confidence evidence

Alanine · multiple reported outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

mixed: 1unknown: 1

PMID 40067859 PMID 42316440

moderate-confidence evidence

beta-Cyclodextrins · multiple reported outcomes

1 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
Some abstracts do not state whether the primary endpoint was met.

mixed: 1

PMID 42316440

moderate-confidence evidence

SBE4-beta-cyclodextrin · multiple reported outcomes

1 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
Some abstracts do not state whether the primary endpoint was met.

mixed: 1

PMID 42316440

Failed or Negative Trials

Adenovirus type 5 vector-based COVID-19 vaccine does not increase the likelihood of HIV infection.

randomized controlled trial · 2026 · PMID 41785679

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

randomized controlled trial · 2026 · PMID 42616612

Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.

randomized controlled trial · 2026 · PMID 42261259

Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial.

randomized controlled trial · 2026 · PMID 42098760

Optimising COVID-19 episode identification using serology and PCR/rapid antigen testing: insights from the BRACE trial.

randomized controlled trial · 2026 · PMID 41947067

Personal household air pollution exposure and SARS-CoV-2 antibody responses among women and infants: an analysis within the HAPIN trial.

randomized controlled trial · 2026 · PMID 41875666

Impact of eccentric exercise on walking functional capacity after severe COVID-19: randomized, controlled open-label trial.

randomized controlled trial · 2026 · PMID 42019312

A pragmatic randomized controlled trial of self-directed online writing interventions for posttraumatic stress symptoms in a real-world digital setting.

randomized controlled trial · 2026 · PMID 42635256

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

randomized controlled trial · 2026 · PMID 42370465

Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts.

randomized controlled trial · 2026 · PMID 42127390

Emerging and Experimental Research

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

preclinical or laboratory · 2027 · PMID 42424692

Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review.

systematic review · 2026 · PMID 42520549

Optimizing Web Links Used in Digital Vaccination Invitations to Raise Trust and Booking Intention: 3 Online Randomized Controlled Trials.

randomized controlled trial · 2026 · PMID 42640841

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

randomized controlled trial · 2026 · PMID 42390526

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

randomized controlled trial · 2026 · PMID 41627968

Safety and immunogenicity of an mRNA COVID-19 vaccine administered to adults: A phase 2, randomized, active-controlled trial.

randomized controlled trial · 2026 · PMID 42647564

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial.

randomized controlled trial · 2026 · PMID 42601614

Phase 1 trial of intranasal NDV-HXP-S in previously vaccinated adults.

randomized controlled trial · 2026 · PMID 42378814

A prematurely terminated phase 2, randomised trial to evaluate immunogenicity and reactogenicity of a single versus two-dose primary vaccination regimen of the mRNA vaccine BNT162b2 in previously SARS-CoV-2 infected children 5-11 years old (CoVacc trial).

randomized controlled trial · 2026 · PMID 42364277

The Effects of Aromatherapy With Thyme Oil on Disease Symptoms, Vital Findings, and Hemodynamic Parameters in COVID-19 Patients: A Randomized Controlled Trial.

randomized controlled trial · 2026 · PMID 40262016

Evidence Gaps

Detailed risk-of-bias assessment remains limited

PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.

Complete Ranked PubMed Index

The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.

BACKGROUND: Virtual care technologies have rapidly expanded in emergency medicine, particularly following the COVID-19 pandemic. However, comprehensive economic evaluations of their cost-effectiveness remain fragmented across different clinical applications and health care settings, creating uncertainty for policymakers and health care administrators considering implementation. OBJECTIVE: This study aimed to systematically review and synthesize evidence on the cost-effectiveness of virtual emergency care models com…

Rank100.0

Systematic review or meta-analysis

Can the Bergen Facebook Addiction Scale be adapted across contexts? Evidence from a COnsensus-based Standards for the selection of health Measurement INstruments systematic review.

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026 · PMID 41973776

OBJECTIVE: The Bergen Facebook Addiction Scale (BFAS) has served as a foundation for a series of adapted measures designed to assess social media-related behavioral addictions. Despite widespread application of these instruments, a systematic evaluation of their psychometric properties is lacking. This review aimed to evaluate the measurement properties of the BFAS and its adaptations using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology. METHOD: A systematic s…

Diagnosis And Screening60 records

Rank98.6

Systematic review or meta-analysis

Systematic review of amino acid profiles among COVID-19 patients caused by SARS-CoV-2.

Journal of diabetes and metabolic disorders · 2026 · PMID 42491141

BACKGROUND: Emerging evidence highlights the critical role of amino acid metabolism in the pathogenesis and severity of COVID-19. This review included studies encompassing patients with varying degrees of disease severity, from mild to critical cases. METHODS: A systematic review following PRISMA guidelines was conducted, and study quality was appraised using the Newcastle-Ottawa tools to explore the relationship between amino acid profiles and clinical outcomes in COVID-19 patients. A comprehensive search of PubMe…

Rank98.5

Systematic review or meta-analysis

Virtual hospital services for adult patients: A scoping review.

International journal of medical informatics · 2026 · PMID 42556091

BACKGROUND AND OBJECTIVES: The COVID-19 pandemic expedited the use of virtual hospital services (VHS) and hybrid hospital-in-the-home (HITH) models. However, the current evidence base remains fragmented and heterogeneous in care model designs, terminology, and reported outcome measures. This scoping review maps the published literature on VHS models implemented or evaluated for adults aged 18 to 65 during and after the COVID-19 period. METHODS: Following the Joanna Briggs Institute (JBI) methodology and Preferred R…

Rank92.0

Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 · PMID 42420160

OBJECTIVES: The PRIME randomized trial demonstrated improved neonatal outcomes using biomarker-guided risk stratification to target interventions to pregnancies at higher risk of preterm birth (PTB). This subgroup analysis evaluated its effectiveness in nulliparous pregnancies, a population with higher baseline risk and limited obstetric history to inform risk assessment. METHODS: PRIME (NCT04301518) was a 19‑center randomized controlled trial evaluating a screen‑guided care strategy using the IGFBP4/SHBG biomarker…

Rank87.5

Randomized clinical study

Duplex Ultrasound Surveillance after Endovascular Therapy for Peripheral Arterial Disease: A Retrospective Cohort Study.

Annals of vascular surgery · 2026 · PMID 42364765

BACKGROUND: Postoperative duplex ultrasound (DUS) surveillance is common practice globally, yet there is limited evidence to demonstrate its efficacy. This study aimed to determine the incidence of adverse events in a contemporary cohort of patients undergoing post endovascular therapy DUS surveillance and to inform the design of a planned randomized controlled trial. METHODS: A retrospective cohort study was conducted at Prince of Wales Hospital, Sydney, Australia. We reviewed consecutive patients who underwent en…

Rank69.8

Prospective cohort study

Associations between maternal lipid metabolism in early pregnancy and postpartum symptoms of depression and anxiety: results from a longitudinal cohort of 266 women.

Journal of psychiatric research · 2026 · PMID 42497820

BACKGROUND: The COVID-19 pandemic has exacerbated psychological vulnerability in perinatal women. Emerging evidence suggests a link between systemic inflammation, lipid metabolism, and mental health. This study aims to evaluate whether first-trimester lipid profiles can predict postpartum depression (PPD) and anxiety in the post-pandemic context. METHODS: A prospective cohort study of 266 pregnant women was conducted. Fasting lipids (Triglycerides, HDL, LDL) were measured at the 12th week of gestation. Mental healt…

Rank60.0

Observational or cohort study

Temporal trends and regional inequalities in oral cancer in Brazil, 2013-2030: An ecological time-series analysis.

Cancer epidemiology · 2026 · PMID 42551071

PURPOSE: This study analyzed temporal trends, the impact of the COVID-19 pandemic, and projections up to 2030 for oral cancer incidence and mortality rates in Brazil, stratified by sex and macro-region. METHODS: This population-based observational study used secondary data from the Department of Informatics of the Brazilian Unified Health System (DATASUS) and the Hospital Information System (SIH/SUS), covering the period from 2013 to 2022. Malignant neoplasms of the oral cavity and major salivary glands (C00-C08, I…

Rank55.6

Other PubMed-indexed publication

Airway Anatomy as a Predictor of Tracheostomy in Critically Ill Patients: A Multicampus Analysis of Airway Grade, Admission Diagnosis, and Clinical Trajectory.

Laryngoscope investigative otolaryngology · 2026 · PMID 42676688

OBJECTIVE: Determine whether the Cormack-Lehane airway grade at intubation predicts subsequent tracheostomy in critically ill adults and whether this association persists after controlling for admission diagnosis. METHODS: Retrospective multicenter cohort study of 10,234 ICU patients requiring ventilation across three campuses from April 2018 to June 2024. The primary predictor was Cormack-Lehane grade (1-4) during intubation; the primary outcome was tracheostomy. Principal problem documentation classified patients…

Rank52.1

Other PubMed-indexed publication

A retrospective analysis of COVID-19 vaccination uptake among patients admitted to psychiatric hospitals in southwest Bavaria.

Journal of psychiatric research · 2026 · PMID 42603342

Individuals with mental illness represent a vulnerable group for coronavirus disease 2019 (COVID-19) severity and mortality, highlighting the need for continued evaluation of preventive measures in this population. Previous studies exploring the COVID-19 vaccination uptake among individuals with mental illness, including comparisons with general population and analyses of high-risk subgroups showed inconsistent results. Large-scale studies from an entire catchment area in Germany are lacking. This retrospective stu…

Rank50.9

Other PubMed-indexed publication

Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.

Pulmonology · 2026 · PMID 41504189

BACKGROUND: The redistribution of pulmonary blood volume (PBV) across COVID-19 severity levels and its prognostic value for the less pathogenic, predominantly upper respiratory tract-infecting Omicron variant remain unclear. This study investigates PBV distribution patterns and validates its predictive utility for Omicron outcomes. METHODS: This retrospective study enrolled consecutive patients (November 2022-January 2023) with baseline CT and clinical data, followed for six months. Patients were divided into mild/…

Rank50.7

Other PubMed-indexed publication

Hair neuroendocrine signatures of acute stress reaction symptoms: Cross-national validation and latent profile heterogeneity.

Journal of affective disorders · 2026 · PMID 42551562

The Acute Stress Reaction (ASR) involves transient emotional, somatic, cognitive, and behavioral symptoms after stressful exposure. Acute stress engages neuroendocrine responses and endocannabinoid systems (ECS), yet their joint links to multidimensional ASR symptoms remain unclear. This study characterizes coupling between hair-based neuroendocrine and ECS markers and ASR symptom dimensions, and tests consistency across countries and symptom severity profiles. Hair steroids, endocannabinoid concentrations and ASR …

Rank50.1

Other PubMed-indexed publicationResult signal: null

Impact of SARS-CoV-2 infection history on the clinical features and outcomes of patients with recurrent pulmonary tuberculosis: a retrospective case-control study.

Annals of medicine · 2026 · PMID 42262973

OBJECTIVE: The impact of prior SARS-CoV-2 infection on the clinical course of recurrent pulmonary tuberculosis (TB) remains poorly defined. This study aimed to compare clinical features, radiographic evolution, and outcomes in recurrent TB patients with and without a history of SARS-CoV-2 infection. METHODS: A retrospective case-control study was conducted. Patients diagnosed with recurrent pulmonary TB between January 2019 and January 2025 were consecutively enrolled. A history of SARS-CoV-2 infection was defined …

Rank49.4

Other PubMed-indexed publication

Evaluation of neuronal and immunological biomarkers in post-COVID-19 condition.

Journal of neuroimmunology · 2026 · PMID 42476066

OBJECTIVE: To investigate evidence of central nervous system (CNS) injury in Post-COVID-19 Condition (PCC) through plasma biomarkers of neuronal damage (APP, NfL, Tau), inflammation (IL-2, IL-6, IL-10, IL-18, IFN-γ, TNF-α), and immune response (IgM, IgA, IgG) in individuals with PCC and neurological symptoms. METHODS: We analyzed 155 volunteers from a post-COVID-19 Center in Rio de Janeiro, categorized into four groups: COVID-19 control (COV; recovered without PCC), PCC without memory loss and reasoning difficulty …

Rank49.3

Other PubMed-indexed publication

Association between COVID-19 status and Leydig cell functional capacity among men in hospitalized cohorts.

The aging male : the official journal of the International Society for the Study of the Aging Male · 2026 · PMID 41902764

BACKGROUND: The first wave of the COVID-19 pandemic in the UK in 2020 led to significant morbidity, hospitalization, and death, particularly amongst elderly men. Recent meta-analyses confirmed that SARS-CoV-2 infection led to reduced testosterone and increased LH, suggestive of testicular Leydig cell involvement. METHODS: The unique Leydig cell biomarker insulin-like peptide 3 (INSL3) was measured in two cohorts of hospitalized men in Nottingham and London with moderate to severe COVID-19 symptoms. RESULTS: For Not…

Rank49.1

Other PubMed-indexed publication

Surface proteome of plasma extracellular vesicles differentiates between SARS-CoV-2 and influenza infection.

Virulence · 2026 · PMID 41263641

Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment. We investigated differences in the surface proteome of plasma sEVs in patients with COVID-19 and Influenza. In a discovery cohort with 117 patients, we used a random forest (RF) classifier in order to discriminate COVID-19 and Influenza patients based on routine clinical parameters. Furthermore, plasma samples from thes…

Rank48.4

Other PubMed-indexed publication

Evaluation of one-step amplicon-based targeted enrichment for SARS-CoV-2 whole-genome sequencing using the Midnight amplicon scheme.

Journal of virological methods · 2026 · PMID 42551833

Genomic surveillance proved invaluable during the COVID-19 pandemic for tracking SARS-CoV-2 variants and guiding outbreak responses, underscoring the ongoing need to reduce whole-genome sequencing (WGS) costs and improve workflow efficiency to ensure accessibility in resource limited settings. Here, we evaluated a one-step reverse transcription polymerase chain reaction (RT-PCR) approach using the Midnight V2 primer scheme for targeted amplification of the SARS-CoV-2 genome, assessed its compatibility with Illumina…

Rank48.3

Other PubMed-indexed publication

Amygdala and hippocampal volumes as neural correlates of resilience and loneliness in older adults.

Neurobiology of aging · 2026 · PMID 42398301

Loneliness and social isolation increase the risk of physical and mental disorders in older adults, while resilience may mitigate this risk. The evidence that medial temporal lobe (MTL) structures are associated with loneliness, social isolation, and resilience is largely cross-sectional. This study examined whether baseline MTL structures were associated with loneliness, social isolation, or resilience during the COVID-19 pandemic. 114 older adults (59 females; mean age: 73.8 ± 5.6 years) completed magnetic resona…

Rank48.1

Other PubMed-indexed publication

Marin-Amat syndrome: a comprehensive review of pathophysiology, clinical presentation, and management.

Orbit (Amsterdam, Netherlands) · 2026 · PMID 42504772

PURPOSE: Marin-Amat syndrome is a rare, acquired facial synkinesis characterized by involuntary eyelid closure upon jaw opening. It is historically confused with other types of synkinesis, despite distinct underlying mechanisms. This scoping review aims to clarify the pathophysiology, clinical presentation, and optimal treatment modalities for Marin-Amat syndrome. METHODS: A comprehensive search was conducted on PubMed, Scopus, Embase, and Web of Science databases following PRISMA-ScR guidelines. Studies published …

Rank48.0

Other PubMed-indexed publicationResult signal: null

Subclinical neurovascular and immune correlates of post-COVID-19 syndrome detected by retinal imaging.

Brain, behavior, & immunity - health · 2026 · PMID 42571220

BACKGROUND: Post-COVID-19 Syndrome (PCS) encompasses a range of persistent symptoms, including cognitive and autonomic disturbances, potentially linked to microvascular or neuroinflammatory mechanisms. Retinal imaging provides a non-invasive window into the central nervous system and vascular integrity. This study aimed to assess retinal structural and microvascular alterations in PCS patients and explore their relationship with symptom severity. METHODS: In this monocentric, cross-sectional, exploratory study, we …

Rank47.9

Other PubMed-indexed publication

Pulmonary and cerebral damage in COVID-19 survivors: is there any association?

Annals of medicine · 2026 · PMID 42305018

BACKGROUND: COVID-19 primarily affects the respiratory system, with pulmonary function tests (PFTs) evaluating respiratory impairments and chest CT imaging revealing structural lung abnormalities. However, the disease's multisystem impact - including vascular dysfunction and neurological complications associated with MRI neuroimaging alterations - raises the possibility of shared mechanisms underlying both pulmonary and cerebral involvement, potentially mediated by vascular damage. MATERIALS AND METHODS: The study …

Rank47.0

Other PubMed-indexed publication

Consensus based expert recommendations for management and prevention of RSV infections in older adults in emerging market countries: results from an expert panel structured survey.

Expert review of vaccines · 2026 · PMID 42596759

BACKGROUND: Respiratory syncytial virus (RSV) can cause serious disease in older adults (OAs), particularly those with comorbidities. It is a leading cause of acute respiratory illness and lower respiratory tract infections in adults ≥60 years. Its impact on morbidity, mortality, and healthcare systems is becoming evident. Questions about the burden of disease (BoD) are raised due to underdiagnosis and the similarity with other respiratory illnesses. First opportunities for prevention came in 2023 and 2024, with va…

Rank47.0

Other PubMed-indexed publication

Management of long COVID-19 in children and adolescents: from diagnosis to therapeutically approaches.

Annals of medicine · 2026 · PMID 41814585

INTRODUCTION: Long Coronavirus disease 2019 (COVID-19), also termed post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC), has emerged as a complex multisystem condition in children and adolescents worldwide. It can occur even after mild or asymptomatic acute infections, with symptoms that may persist, fluctuate, or relapse over time. This review aims to comprehensively explore the characteristic manifestations, management and current therapeutic possibilities of pediatric Long COV…

Rank45.0

Other PubMed-indexed publication

A genome-wide coverage-based pipeline for the identification of host-derived candidate DNA biomarkers from cell-free blood.

Journal of biotechnology · 2026 · PMID 42567273

We have created a new data-analysis pipeline for the discovery of host-specific candidate DNA biomarkers derived from sequencing data of cell-free blood. Unlike approaches that rely on specific molecular or genetic signatures, our method leverages the coverage distribution of cell-free DNA sequences mapped to a reference genome, applying statistical analyses to identify informative short genomic regions for biomarker discovery. The pipeline is applicable to diverse diseases and can be used to analyze cell-free DNA …

Rank45.0

Other PubMed-indexed publication

Impact of the COVID-19 pandemic on clinical laboratories in Japanese hospitals and preparedness for the next pandemic: A nationwide questionnaire survey.

Diagnostic microbiology and infectious disease · 2026 · PMID 42229296

INTRODUCTION: During the coronavirus disease 2019 (COVID-19) pandemic, clinical laboratories faced urgent testing demands for severe acute respiratory syndrome coronavirus 2 amid resource shortages. However, few descriptive studies have documented the challenges faced by hospital laboratories during the pandemic. This study investigated the changes in laboratory and diagnostic capacities in Japanese hospitals before and during the COVID-19 pandemic to help identify issues relevant to pandemic preparedness. METHODS:…

Rank45.0

Other PubMed-indexed publication

Ethanol improves RNase P stability in nasopharyngeal samples stored at room temperature for SARS-CoV-2 RT-qPCR diagnosis.

Diagnostic microbiology and infectious disease · 2026 · PMID 42242126

Despite the end of the global health emergency, COVID-19 and its etiological agent, SARS-CoV-2, remain topics of high scientific and public health relevance due to the continued circulation of the virus, the emergence of new variants, and the persistent risk of outbreaks. RT-qPCR is the gold standard procedure for SARS-CoV-2 detection, but its reliability depends on preserving viral RNA and the human Ribonuclease P (RNase P; internal control) target during sample storage and transport. This study aimed to evaluate …

Rank45.0

Other PubMed-indexed publication

An extraction-free multiplex RT-PCR assay for simultaneous detection of six respiratory pathogens using polychromatic melting curve analysis.

Diagnostic microbiology and infectious disease · 2026 · PMID 42269389

OBJECTIVES: Acute respiratory infections commonly result from a spectrum of pathogens, including SARS-CoV-2, influenza A (IAV) and B viruses (IBV), respiratory syncytial virus (RSV), human adenovirus (HAdV), and Mycoplasma pneumoniae (MP). This study aimed to develop and validate a rapid, extraction-free multiplex RT-PCR assay coupled with polychromatic melting curve analysis (RPCR-MC). This assay enables simultaneous detection of all six pathogens in a single tube. METHODS: Specific primers and TaqMan probes were …

Systematic review or meta-analysis

Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis.

Reviews in medical virology · 2026 · PMID 42536815

Rank108.4

Systematic review or meta-analysis

Prevalence of hypertension in severe vs. non-severe COVID-19: a systematic review and meta-analysis.

Journal of human hypertension · 2026 · PMID 42595776

Rank108.4

Systematic review or meta-analysis

Vitamin D, acute respiratory infections, and Covid-19: The curse of small-size randomised trials. A critical review with meta-analysis of randomised trials.

PloS one · 2025 · PMID 39808630

BACKGROUND: Randomised trials conducted from 2006 to 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI). However, larger randomised trials published in 2022 did not confirm the health benefits of VDS in COVID-19 patients. OBJECTIVE: To examine through a systematic review with meta-analysis the characteristics of randomised trials on VDS to COVID-19 patients and admission to intensive care unit (ICU), and of randomised trials on VDS for the …

Rank106.9

Systematic review or meta-analysis

Prevalence and measurement of post-exertional malaise in post-acute COVID-19 syndrome: A systematic review and meta-analysis.

General hospital psychiatry · 2024 · PMID 39490027

OBJECTIVE: Post-exertional malaise (PEM) is a common and debilitating symptom of post-acute COVID-19 syndrome (PACS), and it is also included in the core outcome set for PACS. Our aims are to determine the prevalence of PEM in patients with PACS, and to review the measurement tools utilized in studies assessing PEM among these patients. METHODS: A systematic literature search was conducted up to 29 February 2024 across four databases: PubMed, EMBASE, Web of Science, and Cochrane Library. Studies were included if th…

Rank106.0

Systematic review or meta-analysis

Genetic evidence that advanced COVID-19 accelerates longitudinal brain atrophy: A Mendelian randomization study.

Medicine · 2026 · PMID 42363551

Coronavirus disease 2019 (COVID-19) was reported to persist long-term in the brain and leave several long-term neurologic sequelae. However, the causal relationship between COVID-19 and brain aging is still unknown. The genome-wide association study (GWAS) data on COVID-19 phenotypes (susceptibility, hospitalization, and severity), involving a total of 5,779,391 participants, were collected from the COVID-19 Host Genetics Initiative. In addition, GWAS data on longitudinal changes in 15 brain structures, assessed vi…

Rank104.8

Systematic review or meta-analysis

Indirect Comparison of the Efficacy of Zanubrutinib vs Ibrutinib and Acalabrutinib in Treatment-Naive Chronic Lymphocytic Leukemia: 6-Year Follow-Up.

Advances in therapy · 2026 · PMID 42274978

INTRODUCTION: Zanubrutinib, acalabrutinib, and ibrutinib each demonstrated improved investigator-assessed progression-free survival (PFS-INV) and overall survival (OS) versus chemotherapy-based regimens in treatment-naive chronic lymphocytic leukemia (CLL) in the phase 3 trials SEQUOIA (NCT03336333), ELEVATE-TN (NCT02475681), and RESONATE-2 (NCT01722487), respectively. In the absence of head-to-head studies, this analysis compared the efficacy of zanubrutinib vs ibrutinib and vs acalabrutinib in treatment-naive CLL…

Rank104.6

Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

OBJECTIVES: The reporting of patient-important outcomes (PIOs) in randomized controlled trials (RCTs) for COVID-19 varies widely, limiting their application in clinical decision-making. We evaluated how often PIOs were reported as primary outcomes in RCTs of COVID-19 treatments and identified trial characteristics associated with their reporting. STUDY DESIGN AND SETTING: This meta-epidemiological study analyzed primary outcome data from 102 RCTs evaluating COVID-19 treatments. RESULTS: Mortality outcomes were more…

Rank104.2

Systematic review or meta-analysis

Factors that impact on healthcare workers' adherence with infection prevention and control (IPC) guidelines for COVID-19: a qualitative evidence synthesis.

The Cochrane database of systematic reviews · 2026 · PMID 42677895

BACKGROUND: The COVID-19 pandemic, declared in 2020, brought unprecedented challenges to our healthcare services in relation to the prevention and treatment of the disease. Additionally, preventing transmission within healthcare settings was critical. Infection Prevention and Control (IPC) guidelines are important for providing strategies on the use of personal protective equipment (PPE), the separation of patients with respiratory infections from others, and stricter cleaning routines. It is important to examine h…

Rank104.1

Systematic review or meta-analysis

Adherence to handwashing behaviour and its impact on the incidence and death of viral respiratory infectious diseases: a systematic review, meta-analysis and modelling study.

BMJ global health · 2025 · PMID 41360478

OBJECTIVES: Washing hands is considered an effective way for preventing viral respiratory infections. This study systematically investigated the global and regional adherence to hand-washing behaviour and its impact on the incidence and death of viral respiratory infectious diseases (VRIDs). METHODS: In our systematic review and meta-analysis, we searched PubMed, Embase, Web of Science and Scopus for related studies. We included observational studies with raw data of adherence to handwashing (rates of acceptability…

Rank103.8

Systematic review or meta-analysis

Implications for future pandemics from a living systematic review and critical evaluation of observational studies of the effectiveness of COVID-19 vaccination against the Omicron variant.

Vaccine · 2026 · PMID 42594644

Reliable evidence on COVID-19 vaccine effectiveness during the period of Omicron variant predominance was essential to inform global vaccination strategies. Our living systematic review, commissioned by the World Health Organization (WHO), was established to provide an ongoing synthesis and critical appraisal of comparative observational studies evaluating the effectiveness of vaccines against COVID-19/SARS-CoV-2 infection caused by the Omicron variant. Weekly searches covering seven databases up to 31 December 202…

Rank103.7

Systematic review or meta-analysis

Post-Infectious Cerebellitis: A Systematic Review of Aetiology, Clinical Presentation, Treatment, and Outcomes.

Cerebellum (London, England) · 2026 · PMID 42649322

Post-infectious cerebellitis is an immune-mediated cerebellar inflammatory syndrome that follows a preceding infection (or, rarely, vaccination) after a latent interval. It spans a spectrum from benign post-infectious/acute cerebellar ataxia (ACA) through more severe acute cerebellitis (AC) with leptomeningeal enhancement and mass effect, to rare, life-threatening acute fulminant cerebellitis (AFC) with hydrocephalus risk. Evidence is largely limited to individual case reports and small case series, and no prior re…

Rank103.7

Systematic review or meta-analysis

Changes in child maltreatment occurrence during the COVID-19 pandemic: A systematic review.

Child abuse & neglect · 2025 · PMID 41201952

BACKGROUND: Child maltreatment (CM) is an important public health issue. During the COVID-19 pandemic, there was widespread concern that CM risk factors were exacerbated while opportunities to seek support were reduced, potentially impacting occurrences of CM. OBJECTIVE: To synthesize evidence evaluating changes in CM outcomes during the COVID-19 pandemic compared to pre-pandemic. PARTICIPANTS AND SETTING: Individuals ≤18 years old living in member countries of the Organization for Economic Co-operation and Develop…

Rank103.3

Systematic review or meta-analysis

Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.

Reviews in medical virology · 2026 · PMID 42536824

Anti-Spike monoclonal antibodies (mAbs) progressively lost efficacy during the COVID-19 pandemic due to the emergence and predominance of resistant SARS-CoV-2 variants. By contrast, high-titre COVID-19 convalescent plasma (CCP) collected from vaccinated donors recently recovered from infection provides a polyclonal source of antibodies that remains effective in clearing SARS-CoV-2 in immunosuppressed patients, unable to mount an adequate immune response against the virus. We conducted a systematic review and indivi…

Rank103.3

Systematic review or meta-analysis

Application of health belief model (HBM) in health sciences and medical researches: systematic review on African and Asian countries.

BMC public health · 2026 · PMID 42351066

BACKGROUND: The Health Belief Model (HBM) is a widely used psychological framework for explaining and predicting individual's health related attitudes, belief, and behaviors. Although the model has been applied across various fields of health and medical sciences, the extent of its global use, particularly across African and Asian countries has not been well documented. OBJECTIVE: This systematic review aimed to assess the application of HBM in health sciences and medical research conducted between 2010 and 2025 in…

Landmark Evidence55 records

Rank107.9

Systematic review or meta-analysis

Persistent symptoms among post-COVID-19 survivors: A systematic review and meta-analysis.

Journal of clinical nursing · 2024 · PMID 36426658

BACKGROUND: Single studies support the presence of several post-COVID-19 symptoms; however, there is no evidence for the synthesis of symptoms. OBJECTIVE: We attempt to provide an overview of the persistent symptoms that post-COVID-19 patients encounter, as well as the duration of these symptoms to help them plan their rehabilitation. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: A total of 16 studies involving 8756 patients post-COVID-19 were included. METHODS: The CINAHL, PubMed, EMBASE, Scopus, and …

Rank107.0

Systematic review or meta-analysis

COVID-19 and healthcare workers: A systematic review and meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021 · PMID 33444754

BACKGROUND: The COVID-19 pandemic has focused attention on the challenges and risks faced by frontline healthcare workers (HCW). This study aimed to describe the clinical outcomes and risk factors for SARS-CoV-2 infection in HCW. METHODS: Three databases were surveyed and 328 articles were identified. Of these, 225 articles did not meet inclusion criteria; therefore, 97 full-text article were reviewed. Finally, after further revision, 30 articles were included in the systematic review and 28 were used for meta-anal…

Rank106.2

Systematic review or meta-analysis

Impact of COVID-19 on testicular function: a systematic review and meta-analysis.

Endocrine · 2024 · PMID 38345682

INTRODUCTION: Studies investigating the effects of SARS-CoV-2 on male reproductive function are few and heterogeneous, and results are often conflicting. This systematic review and meta-analysis was carried out on studies conducted in men with active or anamnestic SARS-CoV-2 infection to evaluate its consequences on the male sex hormone profile and semen parameters. MATERIALS AND METHOD: This meta-analysis follows the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocols. PubMed, Scop…

Rank105.9

Systematic review or meta-analysis

Ischemic stroke associated with COVID-19: a systematic review and meta-analysis.

Journal of neurology · 2022 · PMID 34652503

BACKGROUND: Coronavirus disease 2019 (COVID-19), a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. Apart from respiratory complications, an increasing number of patients with ischemic stroke have been reporting. OBJECTIVE: This systematic review and meta-analysis aims to explore the characteristics of ischemic stroke after SARS-CoV-2 infection, and provides valuable reference materials for subsequent clinical treatment. MATERIALS AND…

Rank105.5

Systematic review or meta-analysis

Endometriosis and COVID-19: A Systematic Review and Meta-Analysis.

International journal of molecular sciences · 2022 · PMID 36361745

Endometriosis is defined as ectopic endometrial tissues dispersed outside the endometrium. This can cause disruption in hormonal and immunological processes, which may increase susceptibility to SARS-CoV-2 infection. Worsening of endometriosis symptoms may occur as a result of this infection. The aim of our review was to estimate the pooled prevalence of SARS-CoV-2 infection and the health impacts of the COVID-19 pandemic in endometriosis patients. We conducted a systematic review and meta-analysis. MEDLINE, Scienc…

Rank104.5

Systematic review or meta-analysis

A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat SARS-CoV-2 in Hospitalized Patients: Have the Guidelines Evolved With the Evidence?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40067859

BACKGROUND: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir, a broad-spectrum antiviral. Given the evolving nature of coronavirus disease 2019, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review with meta-analysis to summarize the effectiveness of remdesivir among hospitalize…

Rank104.3

Systematic review or meta-analysis

Tracheostomy outcomes in coronavirus disease 2019: a systematic review and meta-analysis.

Anaesthesiology intensive therapy · 2021 · PMID 35100800

Tracheostomy is a standard surgical procedure that is used in critically ill patients who require sustained mechanical ventilation. In this article, we review the outcomes of coronavirus disease 2019 (COVID-19) patients who underwent tracheostomy. We searched for relevant articles on PubMed, Scopus, and Google Scholar, up to April 20, 2021. This meta- analysis examines ventilation liberation, decannulation, and hospital mortality rates in COVID-19 patients who have undergone tracheostomy. Two investigators evaluate…

Rank104.0

Systematic review or meta-analysis

Cardiovascular complications of SARS-CoV-2 infection (COVID-19): a systematic review and meta-analysis.

Reviews in cardiovascular medicine · 2021 · PMID 33792257

Coronavirus Disease 2019 (COVID-19) originated in Wuhan, China in December 2019 and rapidly spread worldwide. Herein, we conducted a systematic review and meta-analysis to find the association between COVID-19 and cardiovascular complications. We conducted a systematic literature search of the PubMed and Embase databases from 01 December 2019 to 30 November 2020. We then statistically analyzed the incidence of cardiovascular complications in COVID-19 patients. We included 3044 confirmed COVID-19 cases from 12 studi…

Rank103.0

Systematic review or meta-analysis

Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe outcomes in adults: a systematic review and meta-analysis of European studies published up to 22 January 2024.

European respiratory review : an official journal of the European Respiratory Society · 2025 · PMID 39971395

BACKGROUND: Up-to-date evidence from European studies on long-term vaccine effectiveness (VE) of COVID-19 vaccines is lacking. This review aimed to evaluate effectiveness and durability of primary vaccine series and boosters in preventing infection and severe outcomes in the European population. METHODS: We conducted systematic searches of PubMed and Embase up to 22 January 2024. We included observational studies that evaluated VE against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or sev…

Rank103.0

Systematic review or meta-analysis

Obesity in COVID-19: A Systematic Review and Meta-analysis.

Annals of the Academy of Medicine, Singapore · 2020 · PMID 33463658

OBJECTIVE: Obesity has been shown to be associated with adverse outcomes in viral infections such as influenza, but previous studies on coronavirus disease 2019 (COVID-19) had mixed results. The aim of this systematic review is to investigate the relationship between COVID-19 and obesity. METHODS: We performed a systematic review and meta-analysis. A literature search of MEDLINE, EMBASE, Scopus, Web of Science, CENTRAL, OpenGrey and preprint servers medRxiv and bioRxiv was performed, with no restriction on language…

Rank102.6

Systematic review or meta-analysisResult signal: harm

COVID-19 associated oral and oropharyngeal microbiome: Systematic review and meta-analysis.

Periodontology 2000 · 2024 · PMID 37277934

Three years into the coronavirus disease 2019 (COVID-19) pandemic, there are still growing concerns with the emergence of different variants, unknown long- and short-term effects of the virus, and potential biological mechanisms underlying etiopathogenesis and increased risk for morbidity and mortality. The role of the microbiome in human physiology and the initiation and progression of several oral and systemic diseases have been actively studied in the past decade. With the proof of viral transmission, carriage, …

Rank101.9

Systematic review or meta-analysis

Orofacial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review.

International dental journal · 2022 · PMID 35367044

OBJECTIVES: Studies reviewing orofacial mycoses in coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection are sparse. Here we review the major oral and maxillofacial mycoses of COVID-19, the associated comorbidities, and the probable precipitating factors. METHODS: English-language manuscripts published between March 2020 and October 2021 were searched using PubMed, OVID, SCOPUS, and Web of Science databases, using appropriate keywords. RESULTS: We identified 30 art…

Rank101.4

Systematic review or meta-analysis

Prophylaxis against covid-19: living systematic review and network meta-analysis.

BMJ (Clinical research ed.) · 2021 · PMID 33903131

UPDATES: This is the second version (first update) of the living systematic review, replacing the previous version (available as a data supplement). When citing this paper please consider adding the version number and date of access for clarity. OBJECTIVE: To determine and compare the effects of drug prophylaxis on severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (covid-19). DESIGN: Living systematic review and network meta-analysis (NMA). DATA SOURCES: World…

Rank101.4

Systematic review or meta-analysis

Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta-analysis.

Journal of medical virology · 2021 · PMID 32691881

We aim to systematically review the characteristics of asymptomatic infection in the coronavirus disease 2019 (COVID-19). PubMed and EMBASE were electronically searched to identify original studies containing the rate of asymptomatic infection in COVID-19 patients before 20 May 2020. Then mate-analysis was conducted using R version 3.6.2. A total of 50 155 patients from 41 studies with confirmed COVID-19 were included. The pooled percentage of asymptomatic infection is 15.6% (95% CI, 10.1%-23.0%). Ten included stud…

Rank100.7

Systematic review or meta-analysis

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection.

Diabetes & metabolic syndrome · 2020 · PMID 32771919

BACKGROUND AND AIMS: The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing. The identification of risk factors for severe outcomes is important. Dyslipidemia has been shown as a long-known risk factor for cardiovascular disease. The aim of this study is to analyze the potential association between dyslipidemia and the severity of COVID-19 infection. METHODS: We systematically searched the PubMed database using specific keywords related to our aims until July 9th, 2020. …

Rank100.6

Systematic review or meta-analysis

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis.

Travel medicine and infectious disease · 2020 · PMID 32179124

INTRODUCTION: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date. METHODS: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed c…

Rank100.6

Systematic review or meta-analysis

A systematic review and meta-analysis of the COVID-19 associated liver injury.

Annals of hepatology · 2020 · PMID 32882393

INTRODUCTION AND OBJECTIVES: The novel coronavirus disease 2019 (COVID-19) has affected more than 5 million people globally. Data on the prevalence and degree of COVID-19 associated liver injury among patients with COVID-19 remain limited. We conducted a systematic review and meta-analysis to assess the prevalence and degree of liver injury between patients with severe and non-severe COVID-19. METHODS: We performed a systematic search of three electronic databases (PubMed/MEDLINE, EMBASE and Cochrane Library), from…

Rank100.3

Systematic review or meta-analysis

Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review.

Journal of autoimmunity · 2022 · PMID 36108473

Coronavirus disease 2019 (COVID-19) and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been associated with autoimmune phenomena. However, the interplay between COVID-19 or vaccination against SARS-CoV-2 and Berger glomerulonephritis or Henoch-Schönlein vasculitis, two diseases mediated by immunoglobulin A, has never been comprehensively investigated. Therefore, we carried out a systematic review of the literature on this topic. Following databases were used: Google Scholar, E…

Rank100.1

Systematic review or meta-analysis

Venous thromboembolism in patients with COVID-19: Systematic review and meta-analysis.

Thrombosis research · 2020 · PMID 32853978

BACKGROUND: Venous thromboembolism (VTE) may complicate the course of Coronavirus Disease 2019 (COVID-19). OBJECTIVES: To evaluate the incidence of VTE in patients with COVID-19. METHODS: MEDLINE, EMBASE, and PubMed were searched up to 24th June 2020 for studies that evaluated the incidence of VTE, including pulmonary embolism (PE) and/or deep vein thrombosis (DVT), in patients with COVID-19. Pooled proportions with corresponding 95% confidence intervals (CI) and prediction intervals (PI) were calculated by random-…

Rank100.0

Systematic review or meta-analysis

Outcomes of SARS-CoV-2 infection in early pregnancy-A systematic review and meta-analysis.

Acta obstetricia et gynecologica Scandinavica · 2024 · PMID 38200686

INTRODUCTION: Available data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and pregnancy outcomes mostly refer to women contracting the infection during advanced pregnancy or close to delivery. There is limited information on the association between SARS-CoV-2 infection in early pregnancy and outcomes thereof. MATERIAL AND METHODS: We aimed to systematically review the maternal, fetal and neonatal outcomes following SARS-CoV-2 infection in early pregnancy, defined as <20 weeks of gestati…

Rank100.0

Systematic review or meta-analysis

The persistence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after SARS-CoV-2 infection: A systematic review and meta-analysis.

The Journal of infection · 2024 · PMID 39353473

OBJECTIVES: Long COVID-19 (LC) patients experience a number of chronic idiopathic symptoms that are highly similar to those of post-viral myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We have therefore performed a systematic review and meta-analysis to determine the proportion of LC patients that satisfy ME/CFS diagnostic criteria. METHODS: Clinical studies published between January 2020 and May 2023 were identified using the PubMed, Web of Science, Embase and CINAHL databases. Publication inclusion/…

Rank100.0

Systematic review or meta-analysis

Predictors of post-COVID-19 syndrome: a meta-analysis.

Journal of infection in developing countries · 2025 · PMID 40305533

INTRODUCTION: Post Coronavirus Disease 2019 (COVID-19) Syndrome also known as long COVID-19 would affect survivors of various patients. At present, the evidence for predicting a poor prognosis of COVID-19 remains insufficient. This study aims to explore potential predictors of post-COVID-19 syndrome. METHODOLOGY: A systematic review process and meta-analysis method are applied to identify the predictors. Systematic searches were conducted without language restrictions from December 1, 2019, to February 28, 2022, on…

Rank100.0

Systematic review or meta-analysisResult signal: benefit

Meta-analysis of arbidol versus lopinavir/ritonavir in the treatment of coronavirus disease 2019.

Journal of medical virology · 2022 · PMID 34837230

OBJECTIVES: To systematically evaluate the efficacy and safety of arbidol and lopinavir/ritonavir (LPV/r) in the treatment of coronavirus disease 2019 (COVID-19) using a meta-analysis method. METHODS: The China Knowledge Network, VIP database, WanFang database PubMed database, Embase database, and Cochrane Library were searched for a collection of comparative studies on arbidol and lopinavir/ritonavir in the treatment of COVID-19. Meta-analysis was used to evaluate the efficacy and safety of Arbidol and lopinavir/r…

Rank100.0

Systematic review or meta-analysis

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of Symptoms 3 Years Post-SARS-CoV-2 Infection.

Journal of medical virology · 2025 · PMID 40476637

The symptoms of long COVID are well-documented. However, the long-term effects beyond 2 years remain poorly understood due to a lack of data. This systematic review and meta-analysis examined the prevalence of persistent symptoms in COVID-19 survivors 3 years following initial SARS-CoV-2 infection. PubMed, MEDLINE (Ovid), CENTRAL, Web of Science, Scopus, and Embase were searched from inception of the databases up to July 20, 2024, by two independent researchers for articles reporting on the prevalence of persistent…

Rank99.6

Systematic review or meta-analysis

Comprehensive proteomics and meta-analysis of COVID-19 host response.

Nature communications · 2023 · PMID 37739942

COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them e…

Most Effective Evidence Supported Treatments60 records

Rank110.0

Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920902

Rank110.0

Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

Rank110.0

Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766598

Rank108.6

Systematic review or meta-analysis

Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis.

Reviews in medical virology · 2026 · PMID 42536815

Rank104.8

Systematic review or meta-analysis

Indirect Comparison of the Efficacy of Zanubrutinib vs Ibrutinib and Acalabrutinib in Treatment-Naive Chronic Lymphocytic Leukemia: 6-Year Follow-Up.

Advances in therapy · 2026 · PMID 42274978

Rank104.6

Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

Rank104.4

Systematic review or meta-analysis

Interventions to Support the Mental Health of Frontline Healthcare Workers During the COVID-19 Pandemic: A Systematic Review.

International journal of environmental research and public health · 2026 · PMID 42652397

The COVID-19 pandemic led to distress and an increased prevalence of psychopathology among front-line (FL) healthcare workers (HCWs). A synthesis of the available data on the effectiveness of MH interventions among FL HCWs is essential to inform an MH plan for FL HCWs in future pandemics. The objective of this systematic review is to examine interventions used to support the MH of FL HCWs during the COVID-19 pandemic. All studies published between 1 January 2020 and 1 March 2026 that reported on MH interventions am…

Rank104.2

Systematic review or meta-analysis

Factors that impact on healthcare workers' adherence with infection prevention and control (IPC) guidelines for COVID-19: a qualitative evidence synthesis.

The Cochrane database of systematic reviews · 2026 · PMID 42677895

Rank103.7

Systematic review or meta-analysis

Post-Infectious Cerebellitis: A Systematic Review of Aetiology, Clinical Presentation, Treatment, and Outcomes.

Cerebellum (London, England) · 2026 · PMID 42649322

Rank103.3

Systematic review or meta-analysis

Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.

Reviews in medical virology · 2026 · PMID 42536824

Rank102.6

Systematic review or meta-analysis

A systematic review of observational studies of sodium-glucose cotransporter 2 inhibitors and COVID-19 outcomes: a methodological assessment.

Journal of clinical epidemiology · 2026 · PMID 42203176

OBJECTIVES: To conduct a systematic review of observational studies examining the association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and the risk of mortality and of hospitalization compared with the use of other antidiabetic medications in patients with type two diabetes and COVID-19, with a focus on the methodological quality. We also describe how such studies can be improved when addressing a public health emergency. STUDY DESIGN AND SETTING: We conducted a systematic review by searching Embas…

Rank102.6

Systematic review or meta-analysis

Risk factors for post-COVID-19 condition among previously hospitalized COVID-19 patients: a systematic review and meta-analysis.

Frontiers in public health · 2026 · PMID 42666214

BACKGROUND: Post-COVID-19 condition is a major source of long-term morbidity after SARS-CoV-2 infection. Patients hospitalized for COVID-19 may be at particularly high risk because hospitalization often reflects greater acute disease severity and comorbidity burden. However, evidence on risk factors in previously hospitalized populations remains inconsistent due to differences in outcome definitions, follow-up periods, and analytical approaches. This systematic review and meta-analysis aimed to identify risk factor…

Rank102.6

Systematic review or meta-analysis

Evaluation of nirmatrelvir/ritonavir treatment for COVID-19 on health-related outcomes: a global economic value systematic literature review.

Journal of medical economics · 2026 · PMID 42406565

AIMS: Nirmatrelvir/ritonavir (NMV/r)i is an antiviral drug indicated for the treatment of patients with mild to moderate coronavirus disease 2019 (COVID-19) who are at high risk of progressing to severe disease. We performed an updated economic systematic literature review (eSLR) of NMV/r to build upon evidence reported in our previous eSLR and additionally examine the health-related outcomes associated with NMV/r and any potential effect of long COVID. METHODS: A systematic search of Embase, PubMed, Cochrane, and …

Rank101.2

Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

BACKGROUND: The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we developed…

Rank100.2

Randomized controlled trial

Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.

Expert review of respiratory medicine · 2026 · PMID 42261259

BACKGROUND: Bovhyaluronidase azoximer (BA) has been reported to improve pulmonary function and exercise tolerance in patients with pulmonary sequelae of COVID-19. In this multicenter, randomized, double-blind, placebo-controlled study, we evaluated the effects of BA on patients with long-term (up to 12 months) pulmonary sequelae of COVID-19. METHODS: Patients (n = 392) were randomized 1:1 to receive BA or placebo every 5 days for 71 days. Percent predicted forced vital capacity (ppFVC), respiratory symptoms, and ex…

Rank100.0

Systematic review or meta-analysis

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review.

Journal of psychosomatic obstetrics and gynaecology · 2026 · PMID 42578412

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circumstances. OBJECTIVE: This systematic review aimed to provide an overview of psychological interventions for pregnant women during the COVID-19 pandemic and to evaluate their effectiveness in reducing distress and enhancing resilience. METHO…

Rank100.0

Systematic review or meta-analysis

Psychological interventions for individuals with long COVID: a systematic review and meta-analysis.

Health psychology review · 2026 · PMID 41880671

INTRODUCTION: Long COVID involves a variety of persistent symptoms after initial SARS-CoV-2 infection, affects multiple functional areas and requires multidisciplinary treatment. OBJECTIVE: This study aimed to explore the available evidence about psychological interventions for individuals with long COVID and their effectiveness in reducing some prevalent symptoms, such as fatigue, anxiety or depression, among others, and improving patient quality of life. METHODOLOGY: A systematic review and meta-analysis were con…

Rank100.0

Systematic review or meta-analysis

Timeliness of publication of randomized controlled trials in rheumatology: A systematic review.

Seminars in arthritis and rheumatism · 2026 · PMID 42574892

OBJECTIVE: To systematically review the (1) timeliness of publication of randomized controlled trials (RCTs) in rheumatology, (2) impact of the COVID-19 pandemic on time to publication, and (3) factors associated with publication delays. METHODS: We searched Medline, Embase, EBM Reviews, Cochrane Central Register of Controlled Trials, and Scopus from January 1, 2018, to June 30, 2023 for Phase 3, superiority, parallel-design RCTs that evaluated any treatment for a rheumatologic illness or a rheumatologic treatment …

Rank99.8

Randomized controlled trial

Efficacy of Silver Diamine Fluoride on Young Children With Severe Early Childhood Caries: A Randomized Clinical Trial.

JAMA pediatrics · 2026 · PMID 42507437

IMPORTANCE: Dental caries is a highly prevalent yet preventable disease affecting more than 40% of US children, with severe early childhood caries (S-ECC) leading to serious health and economic consequences. This randomized clinical trial addresses critical evidence gaps by evaluating 38% silver diamine fluoride (SDF) effectiveness for caries arrest in young US children with S-ECC to inform US Food and Drug Administration (FDA) regulatory approval. OBJECTIVE: To assess the efficacy of 38% SDF vs placebo for arresti…

Rank99.0

Systematic review or meta-analysis

Post-COVID Multisystem Inflammatory Syndrome in Children with Kawasaki-like Features: A Scoping Review of Middle Eastern Evidence.

Medicina (Kaunas, Lithuania) · 2026 · PMID 42654497

Background: Multisystem inflammatory syndrome in children (MIS-C) was recognized in 2020 as a post-infectious hyperinflammatory condition occurring 2-6 weeks after SARS-CoV-2 infection. While large studies from Europe and North America have described its clinical spectrum and outcomes, evidence from the Middle East remains limited. MIS-C shares features with Kawasaki disease (KD), including persistent fever, mucocutaneous manifestations, and cardiac involvement, but differs in age distribution, gastrointestinal inv…

Rank98.4

Randomized controlled trial

A pragmatic randomized controlled trial of self-directed online writing interventions for posttraumatic stress symptoms in a real-world digital setting.

European journal of psychotraumatology · 2026 · PMID 42635256

Background: Public health and other large-scale crises, such as the COVID-19 pandemic, have intensified the global mental health burden, creating unprecedented demand for accessible interventions for posttraumatic stress symptoms (PTSS).Objective: We evaluated the feasibility and effectiveness of two self-directed online writing interventions embedded within China's WeChat ecosystem during the COVID-19 pandemic through a pragmatic randomised controlled trial.Methods: Between December 2021 and August 2022, 1,526 adu…

Rank98.0

Systematic review or meta-analysis

Repurposing of colchicine: critical examination of clinical trials and scoping review.

European journal of clinical pharmacology · 2026 · PMID 42618809

PURPOSE: Drug repurposing represents a cost-effective and time-efficient strategy to expand therapeutic treatment options. Colchicine, traditionally used for gout and familial Mediterranean fever, has gained attention as a candidate for diverse conditions. This study aimed to provide a comprehensive and critical overview of clinical trials on colchicine repurposing, with particular focus on reliability, significance, and safety outcomes. METHODS: A structured search of clinicaltrials.gov and the World Health Organi…

Rank98.0

Randomized controlled trialResult signal: harm

Effect of moderate or high versus low dose daily vitamin D on COVID-19 incidence: A double-blind, parallel-group randomized clinical trial.

Clinical nutrition (Edinburgh, Scotland) · 2026 · PMID 42480239

BACKGROUND & AIMS: Vitamin D affects immune function and is associated with lower COVID-19 risk in observational studies. However, randomized clinical trials vary in whether they find vitamin D supplementation affects COVID-19 risk. The objective of this trial was to determine whether moderate or high dose vitamin D (4000 or 10,000 IU/day) versus low dose vitamin D (400 IU/day) affects COVID-19 risk. METHODS: We conducted a double-blind, parallel-group randomized trial (clinicaltrials.gov, NCT0486890) enrolling par…

Rank98.0

Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

CONTEXT: Advanced care planning (ACP) can reduce hospitalizations, increase quality of life, and align treatment with patient wishes, while lowering healthcare costs. However, healthcare providers' discomfort, lack of training, and patient anxiety may hinder ACP. Furthermore, disparities exist among minority and low-income groups. Growing research highlights the need for standardized definitions and broader implementation, especially post-COVID-19, incorporating digital tools, economic impacts, ethics, and family r…

Rank97.9

Randomized controlled trial

Body mass index and baricitinib treatment effect in hospitalized adults with COVID-19: A secondary analysis of ACTT-2.

Heart & lung : the journal of critical care · 2026 · PMID 42247829

BACKGROUND: Obesity alters inflammatory signaling in critical illness. Whether body weight modifies response to targeted immunomodulatory therapy remains unknown. OBJECTIVES: To assess whether body mass index (BMI) and metabolic phenotypes modify the treatment effect of baricitinib in hospitalized adults with COVID-19. METHODS: We conducted a secondary analysis of the Adaptive COVID-19 Treatment Trial 2, which randomized participants to baricitinib plus remdesivir versus placebo plus remdesivir between May and July…

New Research Last 24 Months60 records

Rank100.0

Systematic review or meta-analysis

Stroke risk following BNT162b2 vaccination: a systematic review and meta-analysis of self-controlled case series studies.

Expert review of vaccines · 2026 · PMID 42661284

INTRODUCTION: Whether BNT162b2 (Pfizer-BioNTech) vaccination increases stroke risk remains a public health concern. This is the first meta-analysis to synthesize self-controlled case series (SCCS)-derived stroke risk estimates specifically for BNT162b2 vaccination. METHODS: PubMed and Embase were searched from inception through 9 May 2026, following PRISMA 2020 guidelines. Eight eligible SCCS studies were pooled using a random-effects model with restricted maximum likelihood (REML) estimation and the Knapp-Hartung …

Rank100.0

Systematic review or meta-analysis

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review.

Journal of psychosomatic obstetrics and gynaecology · 2026 · PMID 42578412

Rank100.0

Systematic review or meta-analysis

Exploring the experiences, views, and needs of family members of emergency response workers: a systematic review and meta-synthesis.

European journal of psychotraumatology · 2026 · PMID 42706908

Background: Emergency responders, including firefighters, police officers, and paramedics, face workplace challenges that may harm their well-being. They typically rely on family members for support, which may have damaging effects on the family system. While the experiences of emergency responders are well established, their families' subsequent struggles are less well explored.Objective: This review explores the experiences, views, and needs of family members, through determining the mental health and well-being …

Rank97.5

Randomized controlled trial

Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study).

Gut microbes · 2026 · PMID 42520140

BACKGROUND: Although COVID-19 vaccination has reduced morbidity and mortality, adults aged 65 y old and older are at high risk of complications from COVID-19. The evidence suggests that probiotics may enhance immune responses when co-administered with influenza vaccination. However, few studies have evaluated the potential benefit of probiotic supplementation in this context in this high-risk population. MATERIAL: This study was a randomized controlled trial recruiting adults between 65 and 89 y of age living in Qu…

Rank92.0

Randomized controlled trial

Acceptability of alcohol-based hand rub during neonatal care in rural Ugandan households: a qualitative study nested within the BabyGel trial.

Global health action · 2026 · PMID 42695229

BACKGROUND: Poor access to water, sanitation and hygiene exacerbates the spread of infections among newborns. The BabyGel cluster randomised trial assessed the effectiveness of a community-level alcohol-based hand rub with a training component in reducing infection or death rates among newborns in Uganda. OBJECTIVE: Nested in the BabyGel trial, this study investigated the acceptability of the BabyGel intervention among mothers and household members in Eastern Uganda, using the Theoretical Framework of Acceptability…

Rank92.0

Randomized controlled trial

Modeling of antibody waning after heterologous boosting with Ad5-nCoV in individuals primed with two-dose CoronaVac previously.

Human vaccines & immunotherapeutics · 2026 · PMID 41569047

Heterologous boosting with aerosolized or intramuscular Ad5-nCoV following a two-dose CoronaVac prime has been shown to induce higher antibody levels than a homologous CoronaVac booster. However, no specific modeling has been reported to characterize the kinetics of antibody waning for these heterologous regimens. By integrating longitudinal serological data from three randomized trials conducted in Jiangsu, China (NCT04892459, NCT04952727, NCT05043259), we applied linear mixed-effects models to establish both expo…

Rank70.0

Multicenter clinical study

Adapted XBB.1.5 vaccine effectiveness against severe COVID-19 outcomes among immunocompromised persons in 2023-24 in six European countries: a VEBIS-EHR network study.

Expert review of vaccines · 2026 · PMID 42504085

BACKGROUND: We estimated the XBB.1.5 vaccine effectiveness (VE) against COVID-19 hospitalization and death in Belgium, Denmark, Italy, Portugal, Spain (Navarre), and Sweden following the 2023-24 fall vaccination campaign among immunocompromised persons (ICPs). RESEARCH DESIGN AND METHODS: We conducted a multi-country retrospective cohort study using electronic health records. Study sites identified ICPs aged ≥18 years through a common set of immunocompromising conditions and follow-up started the first day of the 2…

Rank63.5

Observational or cohort studyResult signal: null

T-cell responses to primary SARS-CoV-2 vaccination in Down syndrome - From childhood to adulthood.

Human vaccines & immunotherapeutics · 2026 · PMID 42223472

Down syndrome (DS) is the most common genetic disorder worldwide and associated with high morbidity and mortality rates during the COVID-19 pandemic. For safety reasons, SARS-CoV-2 vaccine schedules and dosages were age-dependent, with children <12 years (y) receiving a lower dose than adolescents and adults. While we previously reported age-dependent antibody responses after SARS-CoV-2 vaccination in children with DS, cellular vaccine responses in this population remain insufficiently characterized. We evaluated v…

Rank60.0

Observational or cohort study

The real-world economic impact of herpes zoster disease in patients with selected underlying conditions in Spain.

Human vaccines & immunotherapeutics · 2026 · PMID 41656881

People with underlying diseases are at-increased-risk of suffering from herpes zoster (HZ). However, the economic impact of HZ on these populations is not well described. This study aimed to quantify the clinical and economic impact of HZ in patients with comorbidities (diabetes, chronic obstructive pulmonary disease, heart disease, kidney disease, asthma) and immune disorders (inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, COVID-19 and psoriatic arthr…

Rank60.0

Observational or cohort study

Costs and healthcare resource utilization after COVID-19 hospitalization among US Medicare patients: a retrospective claims analysis.

Journal of medical economics · 2026 · PMID 42677503

AIMS: The objective of this study was to quantify all-cause direct healthcare costs and healthcare resource utilization (HCRU) in the six months before and after COVID-19-associated hospitalization among Medicare fee-for-service (FFS) beneficiaries during the recent Omicron period (March 2023-March 2025). METHODS: This retrospective observational study used 100% Medicare FFS claims data. Beneficiaries aged ≥65 years with a COVID-19 hospitalization between September 2023 and September 2024 and continuous enrollment …

Rank53.3

Other PubMed-indexed publication

Real-world healthcare resource utilization and cost burden of COVID-19 in commercially insured adults at high-risk of severe disease in the US: a retrospective database analysis.

Journal of medical economics · 2026 · PMID 42693756

BACKGROUND AND AIM: High-risk patients with COVID-19 remained at elevated risk of severe outcomes in the Omicron era, even after receiving multiple vaccine doses. We report the Omicron-era healthcare resource utilization (HCRU) and cost burden of COVID-19 among commercially insured, oral antiviral therapy-eligible patients at high risk of severe disease. METHODS: This retrospective analysis used the TriNetX Linked US database. Eligible commercially insured patients were aged ≥18 years, had a COVID-19 diagnosis betw…

Rank52.4

Other PubMed-indexed publication

Vaccination in patients with cancer: Gaps in coverage, barriers, and the role of clinician recommendations.

Human vaccines & immunotherapeutics · 2026 · PMID 41686169

Cancer patients require a tailored vaccination strategy. This study aims to assess the vaccination status of cancer patients, evaluate disease incidence and severity in vaccinated individuals, identify reasons for noncompliance with guideline-recommended vaccines, and explore vaccine hesitancy. A cross-sectional survey, including 36 multiple-choice and 6 open-ended questions, was conducted in across Turkey. A total of 506 patients participated between September 1, 2024, and December 31, 2024. Among the participants…

Rank52.0

Other PubMed-indexed publication

Covid-19 and influenza vaccine hesitancy insights from France, Italy and Hungary: A mixed-methods study.

Human vaccines & immunotherapeutics · 2026 · PMID 41884998

Since the Covid-19 pandemic entered its endemic phase, France, Italy, and Hungary, as well as many other European countries, have observed a rise in vaccine hesitancy. This study employs a mixed-methods approach to understand the reasons behind this trend by linking statistical observations with in-depth view of vaccine hesitancy. A total of 3,021 adults were surveyed from France, Italy, and Hungary via nationally representative surveys, examining views toward these vaccines. We employed both pooled and un-pooled l…

Rank49.7

Other PubMed-indexed publication

'Well… we keep adapting our labs': Interconnected factors shaping vaccine R&D and production capacity in Brazil.

Global public health · 2026 · PMID 41536243

Over the past century, Brazil has become a hub of excellence in public health research, biomedical sciences and health technology policymaking. However, the Zika outbreak (2016) and the COVID-19 pandemic (2020) exposed critical weaknesses in its healthcare innovation system, particularly regarding the rapid production and delivery of essential technologies. This article examines the interconnected factors shaping vaccine research and development (R&D) and production capacity for neglected and re-emerging diseases i…

Rank49.7

Other PubMed-indexed publication

'When you hear such rumours, you get scared': A comparison of vaccine-related concerns between the oral polio vaccine and Covid-19 vaccines among communities in Cameroon and Ethiopia.

Global public health · 2026 · PMID 42535943

Despite widespread acceptance of the oral polio vaccine (OPV), vaccine hesitancy towards OPV in some countries presents a barrier to global eradication efforts. Between 2021 and 2022, the Global Polio Eradication Initiative implemented OPV campaigns concurrently with the roll-out of Covid-19 vaccines, for which vaccine hesitancy is well-documented. We sought to understand stakeholder perceptions of OPV and Covid-19 vaccines in Cameroon and Ethiopia. We implemented 32 focus group discussions (16 per country) with n …

Rank49.7

Other PubMed-indexed publication

Physical activity, sleep, dietary habits, and screen time in Bogotá's children post-pandemic lockdown: a mixed-methods study.

International journal of qualitative studies on health and well-being · 2026 · PMID 42287140

PURPOSE: This study explored how Bogotá's children reconfigured their post-lockdown routines as part of their lived experience after returning to in-person activities. METHODS: A mixed-methods design was applied to capture behavioral patterns and their meanings. Quantitatively, 217 children aged 8-12 years attending pediatric clinics (Oct 2022-Sep 2023) completed validated questionnaires assessing physical activity, sleep, diet, and screen exposure. Qualitatively, semi-structured interviews were conducted with 15 c…

Rank49.6

Other PubMed-indexed publication

'COVID kills, and it's not joking around': Perceptions and experiences of COVID-19 in Soweto, South Africa.

Global public health · 2026 · PMID 42594851

The COVID-19 pandemic intensified existing social and gender inequalities, disproportionately affecting Black women living in communities like Soweto, South Africa. This paper primarily draws on qualitative data from 25 in-depth interviews conducted in 2021, complemented by descriptive survey data from 204 women collected between 2020 and 2021. We employed inductive thematic analysis guided by the socio-ecological model to examine how intersecting individual, interpersonal, community and societal factors shaped wom…

Rank49.3

Other PubMed-indexed publication

Association between COVID-19 status and Leydig cell functional capacity among men in hospitalized cohorts.

The aging male : the official journal of the International Society for the Study of the Aging Male · 2026 · PMID 41902764

Rank49.2

Other PubMed-indexed publication

Stakeholder recommendations to optimize vaccination implementation and uptake for disease outbreaks: Qualitative insights from less-established adult and childhood vaccination programs in Nigeria.

Global public health · 2026 · PMID 42334339

Achieving sufficient vaccination coverage to mitigate disease outbreaks remains a persistent challenge in Nigeria, particularly for less-established vaccination programs. We aimed to obtain stakeholder recommendations for optimizing the implementation and uptake of less-established adult and childhood vaccination programs in Nigeria. We conducted eight Focus Group Discussions (FGDs) and 53 interviews with 132 participants purposively selected from three Nigerian states, Oyo, Nasarawa, and the Federal Capital Territ…

Rank49.1

Other PubMed-indexed publication

Children's thinking about asymptomatic carriers of disease.

Journal of experimental child psychology · 2027 · PMID 42612397

Prior research has examined children's understanding of disease transmission between people who demonstrate illness symptoms or are labeled as sick (Blacker & LoBue, 2016; DeJesus et al., 2021). The present studies examine North American children's thinking about illness carriers with varying symptoms in terms of the likelihood and severity of disease transmission (Study 1) and moral judgments about disease transmission (Study 2). In Study 1, we tested 6- to 12-year-old children on Zoom (n = 108, 42 % female, 59 % …

Rank49.1

Other PubMed-indexed publication

Maternal bonding and psychological symptoms among women with and without COVID-19 infection: a comparative cross-sectional study.

Journal of psychosomatic obstetrics and gynaecology · 2026 · PMID 42704218

BACKGROUND: Childbirth during the COVID-19 pandemic involved infection-control measures and changes in maternity care that may have increased psychological stress and affected early mother-infant bonding, particularly among women infected at delivery. OBJECTIVE: This study aimed to compare postpartum depressive symptoms, anxiety levels, and mother-infant bonding among women with positive versus negative COVID-19 PCR test results at the time of delivery. METHODS: The study included 107 postpartum women (53 COVID-19 …

Rank48.0

Other PubMed-indexed publication

More than a moment: Evolving decisions among eligible volunteers in phase 1 COVID-19 vaccine trials.

Human vaccines & immunotherapeutics · 2026 · PMID 42721118

Phase 1 vaccine trials rely on healthy participants who accept uncertainty with limited or no personal health benefit. Why people join and why they stay until trial completion is underexplored. Using a modified grounded theory approach, we examined decision making among eligible individuals who enrolled (trial participants (TPs), n = 32) and those that declined enrollment (non-participants (NPs), n = 5) across two phase 1 COVID-19 vaccine trials conducted during the pandemic (Nova Scotia, Canada; 2021-2023). Semi-s…

Rank47.5

Other PubMed-indexed publication

"I thought I was normal" children's understanding of overweight and obesity: a qualitative study in chile.

International journal of qualitative studies on health and well-being · 2026 · PMID 42484054

BACKGROUND: Childhood overweight and obesity are prevalent in Chile and globally. Health care responses typically emphasise biomedical and risk-focused approaches, with limited attention to children's own perspectives. OBJECTIVE: This study explored how children clinically classified as overweight or obese understand health, growth and weight within health contexts. METHODS: Participants were recruited from primary care clinics in two municipalities in Santiago, Chile. Semi-structured online interviews were conduct…

Rank47.0

Other PubMed-indexed publication

'Outbreak distress': Characterising moral distress among international healthcare workers responding to mpox.

Global public health · 2026 · PMID 41629257

In May 2022, a global outbreak of mpox (formerly known as monkeypox) was declared an international public health emergency. During this time, healthcare workers scrambled to respond to the outbreak amidst a lack of resources, knowledge gaps and pressures related to COVID-19. This period posed a risk of heightened moral distress, defined as distress arising from a situation in which a healthcare worker knows the right thing to do but is externally constrained from doing so. An international survey of healthcare work…

Rank47.0

Other PubMed-indexed publication

Eighty years of postwar multilateralism: Global health law's emergence and its contemporary challenges.

Global public health · 2026 · PMID 42312797

Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review.

EBioMedicine · 2026 · PMID 42520549

BACKGROUND: The COVID-19 pandemic created a unique situation in which researchers repurposed human models of varying complexity to investigate SARS-CoV-2, providing the opportunity to analyse their contribution across organs. METHODS: We conducted a systematic review of 558 studies, divided into pandemic and post-pandemic periods, to assess how human models were applied to investigate host factors, viral replication of SARS-CoV-2, immune responses, and to evaluate reporting quality. FINDINGS: Our analysis revealed …

Rank97.7

Randomized controlled trial

Optimizing Web Links Used in Digital Vaccination Invitations to Raise Trust and Booking Intention: 3 Online Randomized Controlled Trials.

Journal of medical Internet research · 2026 · PMID 42640841

BACKGROUND: People are encouraged to respond swiftly to digital health invitations, but they can be (rightly) skeptical about their legitimacy. OBJECTIVE: Drawing on digital communication theory and psychological science, we hypothesized that easy-to-read web links that facilitate participants' ability to identify the health organization as the website host would improve trust in and user engagement with digital communications. METHODS: In 3 double-blind, randomized online experiments, adult UK residents were recru…

Rank97.6

Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.5

Randomized controlled trial

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

Human vaccines & immunotherapeutics · 2026 · PMID 41627968

A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase 1/2 clinical trial. This stratified, observer-blinded study randomly assigned healthy adults (18-75 years) to receive mRNA-1073 (25-µg, 50-µg, or 100-µg) + placebo, mRNA-1…

Rank97.3

Randomized controlled trial

Safety and immunogenicity of an mRNA COVID-19 vaccine administered to adults: A phase 2, randomized, active-controlled trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42647564

We conducted a phase 2, randomized, active-controlled, observer-blind study (NCT05960097) among healthy adults ≥18 y of age who completed a primary COVID-19 mRNA vaccination series, with or without a booster, ≥3 months earlier. Participants were randomized (1:1:1:1:1) to either receive an investigational bivalent mRNA COVID-19 vaccine encoding ancestral D614G and Omicron BA.4-5 spike proteins (CV0701 mRNA vaccine) at one of three dose levels, an investigational monovalent mRNA COVID-19 vaccine encoding the Omicron …

Rank96.3

Randomized controlled trial

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial.

Journal of biomedical science · 2026 · PMID 42601614

BACKGROUND: SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymerase gene, representing a strategy that may enable broader antiviral activity against emerging variants. METHODS: In this phase 2, double-blind, randomised, placebo-controlled trial, adults with mild-to-moderate COVID-19 within 3 days of symptom onset…

Rank95.1

Randomized controlled trial

Phase 1 trial of intranasal NDV-HXP-S in previously vaccinated adults.

Vaccine · 2026 · PMID 42378814

BACKGROUND: Newcastle disease virus hexapro spike (NDV-HXP-S) is a recombinant vaccine designed to elicit both systemic and mucosal immunity against SARS-CoV-2. Intramuscular vaccines protect against severe disease but provide limited mucosal protection. We conducted a Phase 1 trial of live NDV-HXP-S administered intranasally (IN), intramuscularly (IM), or simultaneously (IN+IM) in previously vaccinated adults. METHODS: Thirty-five healthy adults without prior COVID-19 were enrolled at a single site in New York Cit…

Rank95.0

Randomized controlled trial

A prematurely terminated phase 2, randomised trial to evaluate immunogenicity and reactogenicity of a single versus two-dose primary vaccination regimen of the mRNA vaccine BNT162b2 in previously SARS-CoV-2 infected children 5-11 years old (CoVacc trial).

Vaccine · 2026 · PMID 42364277

BACKGROUND: This open-label randomised phase 2 study aimed to determine whether a single versus two-dose BNT162b2 primary vaccination regimen in children 5 to 11 years old with prior SARS-CoV-2 infection was non-inferior in terms of immunogenicity and superior in terms of safety and reactogenicity. METHODS: Participants were randomly assigned (1:1) to receive either one or two doses, spaced 3 to 12-weeks. The primary endpoint was geometric mean ratio (GMR) of neutralizing antibodies against wild-type SARS-CoV-2 at …

Rank94.6

Randomized controlled trial

The Effects of Aromatherapy With Thyme Oil on Disease Symptoms, Vital Findings, and Hemodynamic Parameters in COVID-19 Patients: A Randomized Controlled Trial.

Holistic nursing practice · 2026 · PMID 40262016

The present study aimed to determine the effects of aromatherapy through thyme oil inhalation on respiratory symptoms, hemodynamic parameters and vital signs in COPD patients. The pre-test post-test randomized controlled experimental study was conducted with inpatients COPD (intervention group = 60, control group = 60). Data were collected using the "Patient Information Form", "COPD Symptoms Form", and "Hemodynamic Parameters and Vital Signs Monitoring Form" as well as a saturation device. Following the pre-test, p…

Rank92.0

Randomized controlled trialResult signal: null

Phase IIB, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID-19.

European journal of haematology · 2026 · PMID 42117493

INTRODUCTION: Endothelial dysfunction is key in COVID-19 pathogenesis. This randomized, double-blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS-CoV-2 infection and respiratory failure. METHODS: One-hundred and fifty patients were randomized (2:1) to defibrotide or placebo, stratified by disease severity (WHO COVID-19 severity scale 4/5 vs. 6). The primary endpoint was clinical improvement time (days from first improvement through Day 30). RESULTS: …

Rank92.0

Randomized controlled trial

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42268674

This Phase 1 clinical trial evaluated the safety and immunogenicity of COVAC-2, a recombinant protein subunit vaccine as a heterologous booster in adults previously immunized with authorized COVID-19 vaccines (NCT05226702). COVAC-2 contains the SARS-CoV-2 S1 spike protein subunit adjuvanted with Sepivac SWE™, an open-access oil-in-water adjuvant. Sixty participants were randomized to receive a single intramuscular dose of COVAC-2 (10 µg or 25 µg) or placebo, with follow-up through Day 180. The vaccine was well tole…

Rank85.0

Randomized clinical study

Virtual reality in nursing education: Integrating technology, pedagogy, and learning outcomes - A scoping review.

Nurse education in practice · 2026 · PMID 42492397

AIM: To map and synthesize how VR has been applied in nursing education by integrating technologies, pedagogical strategies, learning outcomes and implementation challenges. BACKGROUND: Virtual Reality (VR) has become an increasingly relevant educational tool in nursing education, particularly following the COVID-19 pandemic. However, evidence remains fragmented across technological, pedagogical and learning dimensions. METHODS: A scoping review was conducted according to the PRISMA Extension for Scoping Reviews (P…

Rank80.3

Phase II clinical trial

Epcoritamab with rituximab and lenalidomide as first-line treatment for follicular lymphoma (EPCORE NHL-2): an open-label, multicentre, phase 1/2 b trial.

The Lancet. Haematology · 2026 · PMID 42660129

BACKGROUND: Chemotherapy-free regimens, such as rituximab and lenalidomide, are attractive first-line treatment options for follicular lymphoma, but combinations providing deeper, more durable responses are needed. We aimed to assess 3-year activity and safety of epcoritamab, a subcutaneously administered CD3 × CD20 bispecific antibody, plus rituximab-lenalidomide as first-line treatment for follicular lymphoma. METHODS: EPCORE NHL-2 is an open-label, phase 1b/2, clinical trial. Arm 6 of the study was conducted at …

Rank79.9

Phase II clinical trial

CD19 CAR T-cell therapy (GLPG5101) for relapsed or refractory B-cell non-Hodgkin lymphoma (ATALANTA-1): phase 1 results from a single-arm, multicentre, phase 1/2 study.

The Lancet. Haematology · 2026 · PMID 42660131

BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapies have transformed the treatment of B-cell non-Hodgkin lymphoma, but centralised manufacturing-with its complex logistics and long vein-to-vein times-drives up costs and restricts access. We aimed to evaluate the safety of GLPG5101, a fresh, CD19 CAR T-cell product manufactured through a decentralised process, and determine the recommended phase 2 dose. METHODS: This phase 1 dose-escalation part of the ATALANTA-1 phase 1/2, single-arm study, was executed in…

Rank75.9

Multicenter clinical study

Effect of Regional COVID-19 Lockdowns on Alcohol Use and Smoking in Two Chilean University Communities: A Difference-In-Difference Analysis.

Drug and alcohol review · 2026 · PMID 42580821

INTRODUCTION: Effects of lockdowns on alcohol use and smoking remain unclear. By exploiting the variation in regional COVID-19 lockdowns in two Chilean regions, we examined their effect on alcohol use and smoking in two university communities. METHODS: We conducted a quasi-experimental study in university communities in two Chilean regions, Coquimbo and Araucanía. Participants were a longitudinal cohort (n = 896) assessed seven times from July 2020 ( t 1 ) to April 2021 ( t 7 ). Outcomes were weekly grams of alcoho…

Rank65.0

Prospective cohort study

SARS-CoV-2 and diabetes: a post-pandemic reappraisal.

Diabetologia · 2026 · PMID 42362970

The COVID-19 pandemic was a dynamic and often confusing period for clinical and biomedical research. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread globally, knowledge accumulated rapidly through publications that were frequently based on preliminary or sometimes conflicting evidence, yet these papers played a critical role in shaping evolving medical, research and societal responses. Early in the pandemic, diabetes emerged as one of the strongest predictors of severe COVID-19 outcomes and m…

Rank51.8

Other PubMed-indexed publication

WIC Benefits Issued Remotely Increased Participation, Especially In States With Online Benefit Distribution, 2017-21.

Health affairs (Project Hope) · 2026 · PMID 42715483

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides food assistance and nutrition education for pregnant and postpartum women and children younger than age five in low-income households. State policy changes implemented during the COVID-19 pandemic aimed to increase WIC access. This study used national administrative data from the period January 2017-March 2021 and a quasi-experimental difference-in-differences approach to assess the associations between five state-level polic…

Rank51.3

Other PubMed-indexed publicationResult signal: null

Long-term follow-up of surgical complications and general health after preoperative optimisation for primary arthroplasty: a prospective quasi-experimental study.

BMJ open · 2026 · PMID 42562582

OBJECTIVES: Preoperative optimisation programmes aim to reduce complications after total joint arthroplasty (TJA), yet long-term effects on superficial surgical site infections (SSI), periprosthetic joint infections (PJI) and overall health remain unclear. This study evaluated the long-term impact of preoperative optimisation in cooperation with hospital and primary healthcare on infection outcomes and general health following elective primary lower extremity TJA. DESIGN: In this prospective quasi-experimental stud…

Rank50.4

Other PubMed-indexed publication

The effects of online intervention program implemented during COVID-19 on the quality of life and physical activities of individuals with intellectual disabilities and their mothers.

Journal of intellectual disabilities : JOID · 2026 · PMID 39134000

The aim of the study was to examine the effect of the Online Intervention Program implemented during the COVID-19 period on the quality of life (QoL) and physical activity (PA) levels of individuals with intellectual disability and their mothers. The experimental method was used in this study. A total of 184 people, 92 individuals with intellectual disability and their mothers participated in the study. By random assignment method, 40 participants with intellectual disability and their mothers were assigned to the …

Rank49.5

Other PubMed-indexed publication

Changing ageist mindsets - An experimental study on the effects of intervention methods on ageist hate speech perception.

Journal of aging studies · 2026 · PMID 42705830

Globally, one in two people discriminates against older adults. The COVID-19 pandemic has exacerbated this issue, as evidenced by the increase in ageist hate speech in social media, highlighting the urgent need to combat ageism also in digital spaces. To identify effective online interventions against ageism and hate speech, this study compares three intervention methods: 1) exposure to counter-stereotypical traits, 2) perspective taking, and 3) implementation intention, focusing on their differences in targeting e…

Rank49.5

Other PubMed-indexed publication

Mobile application intervention for workplace resilience, self-efficacy, and depression in clinical nurses.

Archives of psychiatric nursing · 2026 · PMID 42608109

BACKGROUND: Clinical nurses are particularly vulnerable to stress and psychological distress during public health emergencies such as the COVID-19 pandemic. Workplace resilience is vital for mental health and professional functioning. Mobile app-based interventions offer accessible and flexible support in clinical practice. Such approaches may facilitate scalable support for healthcare workers in dynamic and high-demand settings. Clinical nurses face significant mental health challenges in the post-pandemic context…

Rank48.8

Other PubMed-indexed publication

Effects of a health literacy program on COVID-19 awareness and preventive behaviors among older adults in Bangkok, Thailand: a quasi-experimental study.

Journal of Korean Academy of Nursing · 2026 · PMID 42687651

PURPOSE: This study examined the effectiveness of a health literacy (HL) enhancement program in improving awareness of and preventive behaviors related to coronavirus disease 2019 (COVID-19) among older adults in an urban community in Bangkok, Thailand. METHODS: This quasi-experimental study included 76 older adults in Dusit District, Bangkok. Eight participants were lost to follow-up; however, all 76 participants (38 per group) were included in the primary analysis using all available observations. The interventio…

Rank47.0

Other PubMed-indexed publication

International Comparison of Ambulance Time Intervals for Suspected Stroke/Transient Ischemic Attack Across 7 Emergency Medical Services Before and During the COVID-19 Pandemic.

Journal of the American Heart Association · 2026 · PMID 42657687

BACKGROUND: International reports highlight the COVID-19 pandemic's wide-ranging impacts on time-sensitive conditions, including stroke/transient ischemic attack (TIA). Comparing ambulance time intervals globally offers insights into COVID-19's effects on different health care systems. This study aimed to compare ambulance time intervals for adults with suspected stroke/TIA across 7 services before and during the COVID-19 pandemic. METHODS: We conducted a quasi-experimental before-and-after study examining the impa…

Rank45.0

Other PubMed-indexed publication

Reactive molecular dynamics investigation of the first steps of coronavirus (COVID-19) viral-protein ligands fragment (SARS-CoV-2).

Biophysical chemistry · 2026 · PMID 42302372

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was first identified in the People's Republic of China and is characterized by infection of airway epithelial cells, frequently leading to severe acute respiratory syndrome and clinically diagnosed as severe human pneumonia. The primary targets of SARS-CoV-2 are lung cells, where viral-host interactions trigger extensive molecular and structural changes. In this work, we developed fully atomistic reactive mo…

Rank45.0

Other PubMed-indexed publication

Interrupted time-series analysis of nationwide surveillance in Thai adult pneumococcal diseases over 14 years: evidence to inform policy in resource-limited countries.

Expert review of vaccines · 2026 · PMID 41816940

BACKGROUND: This study aimed to update the incidence and mortality of pneumococcal diseases and to evaluate the population-level trends in pneumococcal diseases incidence in Thailand, following PCV13 licensure and during the COVID-19 pandemic, in order to generate evidence supporting its inclusion in the National Immunization Program (NIP). RESEARCH DESIGN AND METHODS: We conducted a quasi-experimental interrupted time-series analysis using sentinel hospital surveillance data from adults aged ≥ 18 years hospitalize…

Prospective Cohort Studies60 records

Rank101.2

Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

Rank96.0

Systematic review or meta-analysis

Telemedicine-Enabled Surgical Outreach across the Surgical Continuum to Bridge the Gap in Low- and Middle-Income Countries: Lessons from the COVID-19 Era and Applications Beyond.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2026 · PMID 42176257

INTRODUCTION: Telemedicine has revolutionized health care delivery globally, reducing health care costs, increasing patient satisfaction, and improving surgical outcomes. Innovation is often born out of necessity, and during the Coronavirus disease 2019 (COVID-19) pandemic, there was a surge of telemedicine initiatives both in surgical education and surgical care delivery. This has been well documented in high-income countries, but there has been less evaluation of the use and potential application of telemedicine …

Rank90.2

Randomized clinical study

Association Between Pseudoaccommodation Measured With the Salzburg Reading Desk Versus the Reading Chart in Pseudophakic Patients.

Journal of refractive surgery (Thorofare, N.J. : 1995) · 2026 · PMID 42715023

PURPOSE: To assess the incidence and contributing factors of pseudoaccommodation in pseudophakic eyes implanted with aspherically neutral monofocal intraocular lenses (IOLs), comparing printed chart reading under standardized ambient illumination with assessment using the backlit Salzburg Reading Desk (SRD) (SRD Vision, LLC). METHODS: This was a prospective, non-randomized, single-eye cohort study of patients undergoing monofocal IOL implantation for cataract surgery. Uncorrected near visual acuity (UNVA) was measu…

Rank80.6

Multicenter clinical study

Biopsy-to-treatment delay in prostate cancer: Postpandemic impact in a swiss national, multicenter, prospective registry.

Urologic oncology · 2026 · PMID 42436100

BACKGROUND: Surgical delays increased during the COVID-19 pandemic. The effect of treatment delay in intermediate- and high-risk prostate cancer remains uncertain. We evaluated whether biopsy-to-surgery delay influences early oncological outcomes in a large contemporary cohort. METHODS: We analyzed 6,448 intermediate- or high-risk patients from the prospective Swiss national prostatectomy registry (2020-2025). Outcomes were: PSA persistence; adverse pathology (lymph-node invasion [LNI], extracapsular extension [ECE…

Rank79.1

Multicenter clinical study

Evolution of functional and mental status and quality of life in people aged 75 years and over after the COVID-19 pandemic in Spain: a prospective cohort study.

BMC geriatrics · 2026 · PMID 42701179

The COVID-19 pandemic has had significant health and psychosocial consequences in the older adults. However, there is little community-based evidence that clearly distinguishes the effect attributable to SARS-CoV-2 infection to be differentiated from the contextual impact of the pandemic itself. The objective of this study was to describe the 18-month evolution of multidimensional domains of comprehensive geriatric assessment and to compare trajectories according to the presence or absence of confirmed infection at…

Rank79.0

Multicenter clinical study

Association between corticosteroid therapy during acute COVID-19 and Long COVID symptoms: a propensity score overlap-weighted analysis.

Respiratory medicine · 2026 · PMID 42190841

BACKGROUND: The association between acute-phase corticosteroid therapy and subsequent Long COVID symptoms remains uncertain. Therefore, we aimed to evaluate the association between systemic corticosteroid therapy during hospitalization and patient-reported Long COVID symptoms during follow-up. METHODS: In this prospective multicenter observational study, we enrolled adults hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at 26 hospitals in Japan between J…

Rank78.4

Multicenter clinical study

Oropharyngeal swabs show higher bacterial loads than nasopharyngeal swabs for PCR detection of pertussis: a multicenter prospective study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42361964

OBJECTIVE: Pertussis remains a significant public health concern despite widespread vaccination, with a resurgence observed following the COVID-19 pandemic. The optimal sampling site for PCR-based detection of Bordetella pertussis remains uncertain. METHODS: We conducted a multicenter prospective study across five institutions in Japan between October 2024 and May 2025. A total of 475 patients presenting with cough were enrolled. Nasopharyngeal and oropharyngeal swabs were collected and analyzed using real-time pol…

Rank76.9

Multicenter clinical study

Non-traumatic chief complaints in older patients in European emergency departments and associated outcomes during the Covid-19 pandemic - a secondary analysis of the cross sectional EGERS study.

BMC geriatrics · 2026 · PMID 42701177

BACKGROUND: The scope of medical conditions addressed in Emergency Departments (ED) increases with growing numbers of older patients among the ED patient population. More information on their chief complaints and related treatment outcomes is essential to ensure high-quality ED care. The objective of this study was to describe the pattern of chief complaints of older ED patients and evaluate the associations between these complaints and outcomes such as mortality and hospital admission. METHODS: This secondary anal…

Rank75.9

Multicenter clinical studyResult signal: harm

High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

Journal of critical care · 2026 · PMID 42385526

BACKGROUND: Optimal corticosteroid dosing strategies remain unclear for severe coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU). This study compared mortality among patients treated with high-dose versus standard-dose corticosteroids. METHODS: This prospective cohort study included adult patients with COVID-19 ARDS, defined according to Berlin criteria for ARDS, across 22 centers in the Netherlands between March 2020 and January 2021. Mortality hazards were compared between pat…

Rank75.6

Multicenter clinical study

Longitudinal 1H and 129Xe Lung MRI in Patients With Post-COVID Residual Lung Abnormalities.

Journal of magnetic resonance imaging : JMRI · 2026 · PMID 42210667

BACKGROUND: It is unclear how lung function may recover in patients with residual lung abnormalities (RLAs) following COVID-19 pneumonia. PURPOSE: To evaluate lung function trends over time in patients with RLAs following hospitalization due to COVID-19. STUDY TYPE: Prospective, multicenter longitudinal cohort study. POPULATION: Twenty-four participants hospitalized due to COVID-19 with RLAs identified on CT ≥ 3 months postdischarge (median [IQR] age 69 (15) years; 3 female) underwent at least one MRI at 6 months (…

Rank75.3

Multicenter clinical study

COVID-19 vaccination among people with HIV in Uganda: lessons from a high-risk group with high vaccine uptake for the next pandemic.

Vaccine · 2026 · PMID 42430873

BACKGROUND: Despite the effectiveness of the COVID-19 vaccine, vaccination rates vary across settings and populations, especially among people living with HIV (PLHIV). We assessed factors associated with COVID-19 vaccination among PLHIV in Mbarara, Uganda. METHODS: We conducted a cross-sectional, secondary analysis of a prospective cohort study consisting of PLHIV ≥18 years old on antiretroviral therapy (ART). We collected data on COVID-19 vaccine uptake and associated factors beginning in December 2021, 9 months a…

Rank75.0

Prospective cohort study

Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.

Scandinavian journal of primary health care · 2026 · PMID 41496460

BACKGROUND: Women are disproportionately diagnosed with symptom-based conditions, notably post-COVID condition (PCC). In Sweden, as of February 2022, 2.3% of PCR-verified female COVID-19 cases versus 1.6% of male cases had a PCC diagnosis. Post-viral fatigue syndrome (PVFS) and exhaustion disorder (ED), a common and relevant diagnosis in Sweden, share substantial symptom overlap with PCC. AIMS: To quantify the association between pre-pandemic, symptom-based primary-care visits and subsequent PCC, PVFS, and ED among…

Rank74.7

Multicenter clinical study

Impact of diagnostic delay in COVID-19 index cases on SARS-CoV-2 transmission to household contacts.

Medicina clinica · 2026 · PMID 42413342

INTRODUCTION: Diagnostic delay in COVID-19 index cases may increase household transmission of SARS-CoV-2. A prospective epidemiological study was conducted to analyze SARS-CoV-2 infection among household contacts of confirmed COVID-19 cases. METHODS: Recruitment of index cases and their household contacts took place in eight primary care centers. This study included 227 index cases and 329 household contacts and examined the association between the time from symptom onset to index case diagnosis and the household t…

Rank74.1

Prospective cohort study

Long COVID symptoms before and 3-35 months after SARS-CoV-2 infection in a Norwegian prospective cohort study, symptoms over the pandemic, and different virus variants.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42208931

OBJECTIVES: Examine long COVID symptoms and prevalence of symptoms over the pandemic and compare symptoms due to the Omicron variants with symptoms due to earlier variants of the SARS-CoV-2 virus. METHODS: In the present Norwegian prospective cohort study, 11,5737 persons, aged 18-96 years, completed 1-6 questionnaires 3-35 months after a positive and/or negative SARS-CoV-2 test between 2020 and 2023. RESULTS: The following symptoms were reported more frequently 3-35 months after than before a positive SARS-CoV-2 t…

Rank73.6

Prospective cohort study

Effectiveness of Omicron JN.1 vaccination against infection with JN.1-derived SARS-CoV-2 subvariants in a prospective cohort study in the Netherlands.

Vaccine · 2026 · PMID 42585808

INTRODUCTION: We estimated vaccine effectiveness (VE) of JN.1 COVID-19 vaccination against SARS-CoV-2 infection by (sub)variant between 23 September 2024 and 23 February 2025. METHODS: JN.1 vaccine-eligible participants of an ongoing prospective cohort study (VAccine Study COvid-19; VASCO) were included: individuals aged ≥60 years, and individuals aged <60 years with a medical risk condition or who were healthcare workers. In VASCO, questionnaire and serology data are regularly collected and self-tests are provided…

Rank73.3

Prospective cohort study

Association between post-vaccination adverse events and subsequent COVID-19 booster uptake in the Netherlands.

Vaccine · 2026 · PMID 42603508

INTRODUCTION: This study aimed to assess whether the occurrence, severity, and duration of AE following COVID-19 booster vaccination were associated with subsequent booster uptake during the 2022-2024 autumn booster campaigns in the Netherlands. METHODS: We included participants from the Vaccine Study COVID-19 (VASCO), an ongoing prospective cohort study, who were eligible for booster vaccination in 2022-2024. Participants completed a questionnaire on AE one month after booster vaccination. Logistic regression was …

Rank73.0

Multicenter clinical studyResult signal: benefit

IN.PACT AV Access Post-Approval Study of a Paclitaxel Drug-Coated Balloon for the Treatment of Dysfunctional Arteriovenous Dialysis Circuits.

Journal of vascular and interventional radiology : JVIR · 2026 · PMID 42208889

PURPOSE: To report the 12-month safety and effectiveness data of a drug-coated balloon (DCB) for the treatment of de novo or restenotic (nonstented) lesions in native arteriovenous fistulae (AVFs) in patients requiring hemodialysis. MATERIALS AND METHODS: The IN.PACT AV Post-Approval Study is a prospective, multicenter, single-arm study conducted in the United States. In the primary cohort, 159 eligible participants (163 lesions) received DCB treatment at 15 sites and are included in this analysis. The primary endp…

Rank73.0

Multicenter clinical study

Heterogeneity of baseline immune activation and SARS-CoV-2 vaccine responses in people with HIV: a multicenter prospective study.

AIDS (London, England) · 2026 · PMID 42227026

OBJECTIVE: The aim of this study was to determine whether baseline immune activation and inflammation contribute to heterogeneity in SARS-CoV-2 vaccine-induced immunity in antiretroviral therapy (ART)-treated people with HIV (PWH) compared to controls. METHODS: In this multicenter prospective study, 159 ART-treated PWH from two cohorts and 56 HIV-negative controls were enrolled. The two PWH cohorts differed in immunovirological control: one showed sustained viral suppression and CD4 + T-cell recovery, the other per…

Rank72.3

Prospective cohort studyResult signal: harm

Sitting-rising test scores predict natural and cardiovascular causes of deaths in middle-aged and older men and women.

European journal of preventive cardiology · 2026 · PMID 40569873

AIMS: In a previous study, the ability to sit and rise from the floor was associated with all-cause mortality. Now, we aim to assess whether sitting-rising test (SRT) scores also predict premature natural and cardiovascular (CV) deaths. This is a prospective cohort design study. METHODS AND RESULTS: A total of 4282 adults aged 46-75 years (68% men) performed sitting and rising from the floor, which was scored from 0 to 5, with one point being subtracted from 5 for each support used (hand/knee) and 0.5 for an unstea…

Rank71.7

Prospective cohort study

Workforce exit and work productivity loss in adults with and without post-COVID-19 condition: The PRIME post-COVID cohort study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42336192

BACKGROUND: Post-COVID-19 condition (PCC) is highly prevalent, yet evidence on its long-term impact on work participation remains limited. This study assessed workforce exit and work productivity loss among adults with PCC compared to those recovered or without PCC. METHODS: In this prospective cohort study (PRIME post-COVID) in the Netherlands, we used online questionnaire data from adults with a positive COVID-19 test between June 2020 and September 2022. Participants were categorized as PCC (not feeling recovere…

Rank71.7

Prospective cohort study

Low prevalence of bacterial coinfection at hospital admission in COVID-19 and the role of procalcitonin as a rule-out biomarker.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42349772

BACKGROUND: Empirical antibiotic use at hospital admission is common in patients with COVID-19 despite uncertainty regarding the prevalence of bacterial coinfection. Procalcitonin (PCT) has been proposed to support early decision-making, but its diagnostic value at presentation remains unclear. METHODS: We performed a post hoc analysis of a prospective cohort of adults hospitalized with SARS-CoV-2 infection between March 2020 and July 2022 who had PCT measured within 48 hours of admission. Bacterial coinfection at …

Rank70.9

Prospective cohort studyResult signal: harm

Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network.

Human vaccines & immunotherapeutics · 2026 · PMID 42053343

Safety data on COVID-19 and influenza vaccination in immunocompromised and/or autoimmune pediatric populations remains limited. This study evaluated post-vaccination health events in this vulnerable population using active surveillance data from the Canadian National Vaccine Safety (CANVAS) Network. A prospective cohort of participants aged 6 months to 19 y, who self-identified with an autoimmune and/or immunocompromised condition, were followed across several Canadian provinces (2023-2025). Participants were vacci…

Rank70.7

Prospective cohort study

Age-specific humoral immune response to SARS-CoV-2: A comparative analysis of antibody levels in children and adults after vaccination with primary series or infection.

PloS one · 2026 · PMID 42685055

BACKGROUND: Age is a crucial factor in COVID-19 risk and severity, however its role in humoral immunity is unclear. This study compares associations between age and immune response following COVID-19 vaccination and SARS-CoV-2 infection. METHODS: Data from the Arizona Healthcare, Emergency Response, and Other Essential Workers study (AZ-HEROES), a prospective cohort, were used to create two analytic groups: 1) a post-vaccination cohort including individuals who received two doses of the monovalent ancestral mRNA CO…

Rank70.4

Prospective cohort study

Longitudinal changes in the antibody responses and adverse reactions across successive SARS-CoV-2 mRNA vaccinations from the primary series to the JN.1-adapted booster in hospital employees: A 4-year prospective cohort study.

Vaccine · 2026 · PMID 42361783

BACKGROUND: Longitudinal profiles of immunogenicity and reactogenicity across successive SARS-CoV-2 vaccinations, including the XBB.1.5- and JN.1-adapted boosters, remain incompletely characterized. It also remains unclear whether the previously observed association between post-vaccination fever and antibody responses persists with these newer boosters. METHODS: In this prospective open-cohort study of healthcare workers, participants received a primary series followed by first wild-type (WT) booster, BA.4/5 bival…

Rank70.3

Prospective cohort study

Species-specific climate and agricultural determinants of viper bite risk in rural Sri Lanka call for targeted prevention approaches.

Toxicon : official journal of the International Society on Toxinology · 2026 · PMID 42580421

Ecological drivers of snakebite risk are expected to differ between sympatric species, yet few studies have directly tested this. We compared meteorological and agricultural drivers of bites from Hypnale hypnale (hump-nosed viper) and Daboia russelii (Russell's viper) in the dry zone of Sri Lanka. We analysed 424 authenticated viper bites (313 H. hypnale; 111 D. russelii) from a prospective cohort in Anuradhapura (2018-2022), restricted to bites within 15 km of a central meteorological station. Monthly bite counts …

Quality Of Life60 records

Rank104.6

Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

Rank103.1

Systematic review or meta-analysisResult signal: benefit

Impacts of different treatment methods on patients with COVID-related olfactory dysfunction: a systematic review and network meta-analysis.

Clinics (Sao Paulo, Brazil) · 2026 · PMID 42710356

BACKGROUND: Olfactory Dysfunction (OD) is a prevalent neurological sequela of Coronavirus Disease 2019 (COVID-19) and substantially impairs quality of life. Although multiple pharmaceutical and non-pharmaceutical interventions have been proposed, their relative efficacy remains controversial. This study aimed to compare the efficacy of existing interventions for post-COVID-19 OD. METHODS: PubMed, Embase, the Cochrane Library, and Web of Science databases were systematically searched up to July 31, 2025. Randomized …

Rank100.0

Systematic review or meta-analysis

Psychological interventions for individuals with long COVID: a systematic review and meta-analysis.

Health psychology review · 2026 · PMID 41880671

Rank98.0

Systematic review or meta-analysisCorrection flagged

Respiratory medicine · 2026 · PMID 42190841

Rank77.7

Multicenter clinical study

Post-Intensive Care Syndrome in COVID-19 Patients in Spanish ICUs. One-Year Follow-Up. CoronaPICS Study.

Journal of intensive care medicine · 2026 · PMID 41739591

PurposeTo characterize post-intensive care syndrome (PICS) in critical patients who survived COVID-19 during the first pandemic wave and to follow PICS symptoms during one year.Material and methodsProspective, observational, multicenter cohort study conducted in 11 Spanish ICUs. Critically ill adult patients who survived SARS-CoV-2 infection and met risk criteria for PICS were included. In-person follow-up was conducted at 3, 6, and 12 months after hospital discharge, assessing physical, cognitive, psychological, a…

Rank67.9

Prospective cohort studyResult signal: null

Limited observed efficacy of olfactory training in severe long-term post-COVID-19 syndrome: a prospective cohort study.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 · PMID 42704468

PURPOSE: Persistent chemosensory dysfunction is a debilitating symptom of Post-COVID-19 Syndrome (PCS). While olfactory training (OT) is effective in early post-viral smell loss, its efficacy in chronic, multisystemic PCS remains unclear. This study aimed to characterize a severely affected cohort and to evaluate changes in olfactory function during a structured OT intervention. METHODS: In this prospective study, 29 patients with persistent PCS lasting > 12 weeks (mean duration approximately 30 months) were recrui…

Rank66.6

Observational or cohort study

Respiratory symptoms up to 18 months after COVID-19 - a longitudinal observational study.

Respiratory research · 2026 · PMID 42717356

BACKGROUND: This study aimed to identify, analyse and compare adults with and without respiratory symptoms over time after COVID-19 and identify predictors of persistent respiratory symptoms, in hospitalised and non-hospitalised patients. METHODS: Participants were recruited at the Post COVID-19 clinic at Karolinska University hospital, Sweden, between May 2020 until December 2022, with longitudinal data collected until February 2025. Data from medical records and two clinical follow-up visits were analysed. Partic…

Rank65.0

Prospective cohort study

Correlates of fatigue in SARS-CoV-2-positive and -negative adolescents and young adults: Repeated cross-sectional analyses from a prospective cohort study.

Journal of psychosomatic research · 2026 · PMID 42235362

PURPOSE: To investigate cross-sectional associations between concurrent fatigue and a range of covariates in adolescents and young adults with acute SARS-CoV-2 infection and follow-up six months after infection, as well as in SARS-CoV-2-negative controls. METHODS: A total of 404 SARS-CoV-2 -positive adolescents and young adults were studied during their infection and again six months post-infection, compared to 105 SARS-CoV-2-negative controls. In this exploratory study, cross-sectional linear regression analyses w…

Rank64.6

Observational or cohort study

Quality of life of people with and without respiratory complications in post-COVID-19 syndrome: a retrospective study.

Revista brasileira de enfermagem · 2026 · PMID 42659491

OBJECTIVES: to assess and compare the quality of life (QoL) of people with and without respiratory complications resulting from post-COVID-19 syndrome. METHODS: a retrospective, comparative, and analytical observational study, with a quantitative approach and non-probabilistic convenience sampling, conducted with 300 people residing in Ceará, Maranhão, or Pernambuco, distributed into case group (n=100/with respiratory complications) and control group (n=200/without respiratory complications). For data collection (2…

Rank60.0

Observational or cohort studyResult signal: null

Influence of COVID-19 on the effectiveness of a cardiac rehabilitation programme in patients with coronary heart disease.

Respiratory medicine · 2026 · PMID 42342135

BACKGROUND: Cardiac rehabilitation (CR) improves quality of life, functional capacity, and cardiovascular outcomes in patients with coronary heart disease (CHD). However, post-COVID-19 sequelae may affect baseline physical condition and potentially influence CR outcomes. OBJECTIVES: To compare baseline inspiratory muscle strength, hand grip force, cardiorespiratory function and quality of life in CHD patients with and without prior COVID-19, and to evaluate their response to a CR programme. METHODS: A prospective o…

Rank53.9

Other PubMed-indexed publication

Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.

Human vaccines & immunotherapeutics · 2026 · PMID 42610257

The aim of the present study was to prospectively investigate the associations between psychological wellbeing and COVID-19 outcomes (vaccination, infection, long COVID) based on the Survey of Health, Aging, and Retirement in Europe (SHARE), using the data from Wave 8 and two supplementary COVID-19 surveys (Corona Survey 1 and 2) covering 27 European countries and Israel. Furthermore, we also conducted a cross-sectional study to evaluated the joint effects of wellbeing and vaccination status on the risks of SARS-Co…

Rank52.8

Other PubMed-indexed publication

Real-World Evidence for the Impact of Minimal Disease Activity on Quality of Life in Atopic Dermatitis: An Interim Analysis of the Prospective, Multicenter, Non-Interventional UP-TAINED Study.

Dermatology and therapy · 2026 · PMID 42533213

INTRODUCTION: Minimal disease activity (MDA) has recently been introduced as comprehensive treatment target in atopic dermatitis (AD), integrating both clinician- and patient-reported outcomes. Evidence on the real-world feasibility and impact of achieving MDA on quality of life (QoL) remains limited. This analysis evaluated the association between MDA achievement and QoL outcomes in patients with moderate-to-severe AD receiving upadacitinib (UPA) in real-world clinical practice. METHODS: This interim analysis used…

Rank51.9

Other PubMed-indexed publication

Patient-centered communication and emotional well-being among cancer survivors: The role of online peer interaction and the COVID-19 context.

Patient education and counseling · 2026 · PMID 42632321

OBJECTIVE: Patient-centered communication (PCC) predicts better emotional well-being among cancer survivors, but whether this benefit holds across changing care contexts is unclear. The COVID-19 pandemic, which disrupted in-person care and shifted survivors toward digital support, offers a natural test of whether PCC's value depends on context. We examined how the PCC-well-being association varies across pandemic periods and online participation, and whether self-efficacy consistently mediates it. METHODS: Data cam…

Rank51.7

Other PubMed-indexed publication

Residual Burden in Adalimumab-Treated Patients with Hidradenitis Suppurativa: An Observational Cohort Study Based on Insurance Claims in the USA.

Drugs - real world outcomes · 2026 · PMID 42525209

INTRODUCTION: Hidradenitis suppurativa (HS), a chronic, inflammatory skin disease, causes significant morbidity. Until 2023, adalimumab was the only US-approved biologic for patients with moderate to severe HS. AIM: This study describes the clinical profile, treatment utilization, and residual disease burden in patients with HS initiating adalimumab in the USA. METHODS: This observational cohort study used data from the Merative MarketScan® Commercial, Medicare, and Multi-State Medicaid claims databases. Adult pati…

Rank50.8

Other PubMed-indexed publication

Sex-stratified neuropsychiatric manifestations of post-COVID-19 condition: A Japanese National Registry of clinical and patient-reported outcomes (PSCORE-J).

General hospital psychiatry · 2026 · PMID 42574927

AIM: To establish and characterize neuropsychiatric manifestations of post-COVID-19 condition (PCC) through Japan's first nationwide registry integrating clinical assessments with patient-reported outcomes. METHODS: The Psychiatric Symptoms for COVID-19 Registry Japan collected data between December 2022 and September 2024, integrating electronic patient-reported outcomes (n = 806) with in-person clinical assessments (n = 136). Participants were classified as cases or tolerant controls following WHO criteria. The C…

Rank50.8

Other PubMed-indexed publication

Prevalence and risk factors of adverse work outcomes among manufacturing workers with Long COVID in Malaysia - A nationwide study.

PloS one · 2026 · PMID 42726744

INTRODUCTION: The increasing prevalence and multiorgan involvement of Long COVID among the general population has raised concerns about the possible long-term effect of this condition among industrial workers. Therefore, this study seeks to determine the prevalence and risk factors of adverse work outcomes among Malaysian manufacturing workers affected by Long COVID. MATERIALS AND METHODS: A cross-sectional survey was conducted using the Long COVID Questionnaire, Work-Related Quality of Life (WRQoL) Scale, and the …

Rank50.5

Other PubMed-indexed publication

Somatic symptom burden and distress in post COVID-19 and persistent physical symptoms: Evidence from combined SSD-12 and PHQ-15 factor analysis.

Journal of psychosomatic research · 2026 · PMID 42068900

BACKGROUND AND AIM: Post COVID-19 condition (PCC) and persistent physical symptoms (PPS) may involve overlapping symptom presentations. We examined whether symptom-related dimensions differ or overlap between PCC and functional somatic disorders by comparing Somatic Symptom Disorder-B Criteria Scale (SSD-12; cognitive-affective distress) and the Patient Health Questionnaire-15 (PHQ-15; somatic symptom burden), and by performing a joint factor analysis of their items. METHODS: Two cohorts at Helsinki University Hosp…

Rank50.4

Other PubMed-indexed publication

The effects of online intervention program implemented during COVID-19 on the quality of life and physical activities of individuals with intellectual disabilities and their mothers.

Journal of intellectual disabilities : JOID · 2026 · PMID 39134000

Rank50.3

Other PubMed-indexed publication

Association of oral outpatient antiviral medications for COVID-19 with the risk of post-acute sequelae of COVID-19 at 28 and 90 days in a cohort of individuals with systemic autoimmune rheumatic diseases.

Clinical rheumatology · 2026 · PMID 42461564

INTRODUCTION/OBJECTIVES: Prior studies have evaluated the relationship between antiviral medications for COVID-19 and the risk of post-acute sequelae of COVID-19 (PASC, i.e., "long COVID") in the general population. We evaluated PASC in individuals with systemic autoimmune rheumatic diseases (SARDs) by antiviral use, hypothesizing that antivirals are associated with lower PASC risk. METHODS: We investigated oral outpatient antiviral use (nirmatrelvir/ritonavir or molnupiravir) and PASC in a prospective SARD cohort …

Randomized Controlled Trials127 records

Rank108.6

Systematic review or meta-analysis

Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis.

Reviews in medical virology · 2026 · PMID 42536815

Rank108.4

Systematic review or meta-analysis

Vitamin D, acute respiratory infections, and Covid-19: The curse of small-size randomised trials. A critical review with meta-analysis of randomised trials.

PloS one · 2025 · PMID 39808630

Rank104.6

Systematic review or meta-analysis

Patient-important outcomes reported as primary outcomes in clinical studies of treatments for COVID-19: a meta-epidemiological study.

Journal of clinical epidemiology · 2026 · PMID 42309365

Rank103.8

Systematic review or meta-analysis

Expert review of respiratory medicine · 2026 · PMID 42261259

Rank100.0

Systematic review or meta-analysis

Seminars in arthritis and rheumatism · 2026 · PMID 42574892

Rank99.8

Randomized controlled trial

European journal of psychotraumatology · 2026 · PMID 42635256

Rank98.2

Randomized controlled trialResult signal: null

Impact of the Smarter Safer Homes Solution on Quality of Life and Health Outcomes in Older People Living in Their Own Homes: Randomized Controlled Trial.

Journal of medical Internet research · 2025 · PMID 39608020

BACKGROUND: An increasingly aging population, accompanied by a shortage of residential aged care homes and workforce and consumer feedback, has driven a growing interest in enabling older people to age in place through home-based care. In this context, smart home technologies for remote health monitoring have gained popularity for supporting older people to live in their own homes. OBJECTIVE: This study aims to investigate the impact of smart home monitoring on multiple outcomes, including quality of life, activiti…

Rank98.2

Randomized controlled trial

Immunogenicity and safety of SARS-CoV-2 recombinant protein vaccine (CHO cell) LYB001 as a heterologous booster following two- or three-dose inactivated COVID-19 vaccine in adults aged ≥18 years: interim results of a randomized, active-controlled, double-blinded, phase 3 trial.

Expert review of vaccines · 2025 · PMID 39720838

BACKGROUND: LYB001 is a recombinant protein COVID-19 vaccine displaying a receptor-binding domain (RBD) in a highly immunogenic array on virus-like particles (VLPs). This study assessed the immunogenicity and safety of LYB001 as a booster. RESEARCH DESIGN AND METHODS: In this randomized, active-controlled, double-blinded, phase 3 trial, participants aged ≥ 18 years received a booster with LYB001 or ZF2001 (Recombinant COVID-19 Vaccine). The primary endpoint was to compare the geometric mean titer (GMT) of neutraliz…

Rank98.1

Randomized controlled trial

Passive Remote Monitoring Technologies' Influence on Home Care Clients' Ability to Stay Home: Multiprovincial Randomized Controlled Trial.

JMIR aging · 2025 · PMID 40106817

BACKGROUND: Researchers in Nova Scotia and Ontario, Canada, implemented a passive remote monitoring (PRM) model of home care unique to their health system contexts. Each PRM model integrated tailored PRM devices (eg, motion sensors, cameras, and door alarms) into home care patients' residences with the aim of linking patients, family and friend caregivers, and health care providers to support older adults' aging in place. OBJECTIVE: The purpose of this study was to examine the use of PRM technologies in the home to…

Rank98.0

Randomized controlled trialResult signal: harm

Effect of moderate or high versus low dose daily vitamin D on COVID-19 incidence: A double-blind, parallel-group randomized clinical trial.

Clinical nutrition (Edinburgh, Scotland) · 2026 · PMID 42480239

Rank97.9

Randomized controlled trial

Chest · 2025 · PMID 39303806

BACKGROUND: In the Handling Oxygenation Targets in COVID-19 (HOT-COVID) trial, a Pao2 target of 60 mm Hg compared with 90 mm Hg resulted in more days alive without life support at 90 days in adults in the ICU with COVID-19 and hypoxemia. The trial was stopped after enrolling 726 of 780 planned patients because of slow recruitment. Herein, we present the preplanned Bayesian analysis of the HOT-COVID trial. RESEARCH QUESTION: What are the probabilities of any benefits and of clinically relevant benefits resulting fro…

Safety And Adverse Effects60 records

Rank100.0

Systematic review or meta-analysis

No fault vaccine injury compensation after COVID-19: A systematic literature review and proposed typology.

Human vaccines & immunotherapeutics · 2026 · PMID 41630128

Human vaccines & immunotherapeutics · 2026 · PMID 42268674

Rank92.0

Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

Rank92.0

Randomized controlled trial

Acceptability of alcohol-based hand rub during neonatal care in rural Ugandan households: a qualitative study nested within the BabyGel trial.

Global health action · 2026 · PMID 42695229

Rank90.0

Randomized clinical study

GOLDEN: Efficacy and Safety of Complement Factor B Antisense, Sefaxersen, in Geographic Atrophy due to Age-Related Macular Degeneration.

Ophthalmology science · 2026 · PMID 42718940

OBJECTIVE: To evaluate the efficacy and safety of sefaxersen, an investigational antisense oligonucleotide targeting complement factor B (FB), in slowing the progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). DESIGN: Randomized, double-masked, placebo-controlled, adaptive phase II clinical trial. SUBJECTS: A total of 332 patients with GA secondary to AMD were enrolled, with 91% of treated patients completing the final study visit at 56 weeks. METHODS: In stage 1, 58 patients…

Rank87.5

Randomized clinical study

Duplex Ultrasound Surveillance after Endovascular Therapy for Peripheral Arterial Disease: A Retrospective Cohort Study.

Annals of vascular surgery · 2026 · PMID 42364765

Rank85.0

Randomized clinical study

Modeling the cost-effectiveness of the next-generation COVID-19 mRNA-1283 vaccine in the United States.

Journal of medical economics · 2026 · PMID 41764030

AIMS: COVID-19 disease burden in United States (US) adults ≥65 years and persons with underlying medical conditions remains high. This modeling study estimated the cost-effectiveness of the next-generation COVID-19 mRNA-1283 vaccine in persons aged 12-64 at high risk of severe COVID-19 outcomes and all adults ≥65 years. METHODS: mRNA-1283 was compared with no annual vaccination and originally licensed mRNA vaccines mRNA-1273 and BNT162b2. Analyses were conducted using a static decision-analytic model (1-year horizo…

Rank85.0

Randomized clinical study

Rationale, design, and methods of the dietary approaches to stop hypertension for diabetes (DASH4D) controlled feeding trial.

Contemporary clinical trials · 2026 · PMID 42607881

Diabetes and hypertension frequently coexist, greatly increasing cardiovascular and mortality risk. The optimal dietary strategies for blood pressure (BP) control in people with diabetes remain uncertain. This report details the rationale and design of the Dietary Approaches to Stop Hypertension for Diabetes (DASH4D) trial, a randomized, controlled, crossover feeding study designed to evaluate the effects of the DASH4D dietary pattern and sodium content on BP among adults with type 2 diabetes. The DASH4D dietary pa…

Rank73.0

Multicenter clinical study

The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.

Human vaccines & immunotherapeutics · 2026 · PMID 42246636

Hospitalization for vaccine-preventable infections may influence parental vaccination attitudes, but comparative data for influenza and COVID-19 are limited. We conducted a multicenter observational study of unvaccinated children hospitalized with influenza or COVID-19 in Poland. We collected clinical data and parental survey data assessing vaccination regret, future vaccination intentions, willingness to encourage others, interest in vaccination reminders, reasons for non-vaccination, and sources of influence. Par…

Rank70.9

Prospective cohort studyResult signal: harm

Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network.

Human vaccines & immunotherapeutics · 2026 · PMID 42053343

Rank63.5

Observational or cohort studyResult signal: null

T-cell responses to primary SARS-CoV-2 vaccination in Down syndrome - From childhood to adulthood.

Human vaccines & immunotherapeutics · 2026 · PMID 42223472

Rank55.0

Other PubMed-indexed publication

Cardiac outcomes following SARS-CoV-2 infection versus BNT162b2 vaccination in adolescents and young adults: a cohort study of 4 million individuals.

Vaccine · 2026 · PMID 42607625

BACKGROUND: Concerns about myocarditis and mortality after COVID-19 vaccination in pediatrics persist despite limited direct comparisons with SARS-CoV-2 infection risks. We compared risks of myocarditis, pericarditis, and mortality between infection and BNT162b2 vaccination in adolescents and young adults. METHODS: This retrospective cohort study used TriNetX data (December 2020-September 2025) for 4,072,375 individuals aged 16-25 years, categorized as uninfected/unvaccinated (n = 3,572,000), infected/unvaccinated …

Rank55.0

Other PubMed-indexed publication

Retrospective cohort study of mRNA COVID-19 vaccine-associated enhanced disease in the Vaccine Safety Datalink, 2021-23.

Human vaccines & immunotherapeutics · 2026 · PMID 42252746

Vaccine-associated enhanced disease (VAED) was recognized as a theoretical risk when COVID-19 vaccines were authorized. Epidemiologic data can identify a signal for VAED if vaccine effectiveness (VE) is negative for preventing serious illness. In 2021, we initiated a cohort study to examine VAED indirectly by estimating VE against COVID-19 hospitalization and severe illness in the Vaccine Safety Datalink. The study cohort included VSD enrollees who were age-eligible to receive mRNA COVID-19 vaccine from February 20…

Rank54.6

Other PubMed-indexed publication

Safety of Matrix-M-adjuvanted COVID-19, seasonal influenza, combination influenza-COVID-19, and malaria vaccines: a review of the evidence.

Expert review of vaccines · 2026 · PMID 41814863

INTRODUCTION: The saponin-based Matrix-M adjuvant induces potent and durable immunity through producing long-lasting memory B-cells and broad-based T-cell immunity, across a variety of vaccine platforms. Matrix-M-adjuvanted vaccines have a history of successful development for protection against a broad range of infectious diseases with high public health urgency. Two authorized Matrix-M-adjuvanted vaccines, NUVAXOVID (COVID-19) and R21/Matrix-M (Plasmodium falciparum malaria), have been administered to >10 million…

Rank53.8

Other PubMed-indexed publication

Analysis of vaccine adverse events associated with rheumatoid arthritis: A pharmacovigilance study based on the VAERS database.

Human vaccines & immunotherapeutics · 2026 · PMID 42522140

Vaccination is a principal method of infectious disease prevention, but its association with rheumatoid arthritis (RA) remains controversial. This study assessed vaccine‑associated RA using the Vaccine Adverse Event Reporting System (VAERS). Data from 1990 to 2026 were extracted. Descriptive statistics, Weibull fitting, and disproportionality analysis using four methods, including the reporting odds ratio (ROR), along with subgroup analyses by age, sex, and pre‑/post‑COVID, were performed. Among 11,532,185 reports,…

Rank53.6

Other PubMed-indexed publicationResult signal: harm

A cohort study to assess the safety and coverage of COVID-19, influenza, and pertussis vaccine in Australian pregnant women.

Vaccine · 2026 · PMID 42667899

BACKGROUND: The study aimed to evaluate the safety and impact of maternal influenza, pertussis, COVID-19 vaccine on perinatal outcomes and identify determinants of uptake among pregnant women in South Australia. METHODS: This retrospective cohort study included 19,098 pregnant women who delivered at the Women's and Children's Hospital in South Australia between 2020 to 2023. Cox proportional-hazards models estimated hazard ratios (HRs) for time-sensitive perinatal outcomes, and log-binomial models were used for tim…

Rank53.1

Other PubMed-indexed publication

The role of age, sex, and ethnicity in vaccine trust, and sources of information in Canada: Findings from a national survey.

Human vaccines & immunotherapeutics · 2026 · PMID 41640305

Vaccine confidence plays a critical role in public health. Understanding demographic differences in trust and sources of vaccine information is essential for designing equitable communication strategies. We analyzed nationally representative summary data from Cycle 2 of the Canadian COVID-19 Vaccine Coverage Survey (CVCS), collected April-May2021 during the initial phase of the national vaccine rollout. The survey included adults aged 18 and older (n = 10,678). This study examines trust in vaccine safety, efficacy,…

Treatments That Failed Clinical Trials60 records

Rank101.3

Randomized controlled trialResult signal: harm

Adenovirus type 5 vector-based COVID-19 vaccine does not increase the likelihood of HIV infection.

Vaccine · 2026 · PMID 41785679

BACKGROUND: There is a concern about the potential increased risk of acquiring HIV infection after vaccination with adenovirus type 5 (Ad5) vector-based vaccines. We aimed to investigate whether Ad5-nCoV increases the risk of HIV infection. METHODS: Between September 2020 and March 2021, a Phase 3 clinical trial was executed to evaluate the efficacy of Ad5-nCoV. This trial, employing a double-blind, randomized, and placebo-controlled design, enrolled 44,247 participants from 66 clinical sites spanning Argentina, Ch…

Rank101.2

Randomized controlled trial

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

JMIR aging · 2026 · PMID 42616612

Rank100.2

Randomized controlled trial

Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.

Expert review of respiratory medicine · 2026 · PMID 42261259

Rank99.3

Randomized controlled trialResult signal: null

Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial.

Implementation science : IS · 2026 · PMID 42098760

BACKGROUND: "Nudges" embedded in the electronic health record (EHR) facilitate desired decisions while preserving autonomy and may provide a scalable strategy to overcome the common implementation barrier of lack of knowledge about a best practice. We sought to test whether EHR-based nudges targeting two intensive care unit (ICU) clinician groups would safely increase evidence-based use of low tidal volume ventilation. METHODS: We performed a stepped-wedge, cluster randomized, hybrid type 3 effectiveness-implementa…

Rank99.2

Randomized controlled trial

Optimising COVID-19 episode identification using serology and PCR/rapid antigen testing: insights from the BRACE trial.

Assessing a facilitated social network intervention for health outcomes in lonely and socially isolated people: the pragmatic, cluster-randomized PALS trial.

Frontiers in public health · 2026 · PMID 41982893

INTRODUCTION: Loneliness has received attention in recent years as an important public health issue due to its associations with poorer mental and physical health. This study aimed to assess the effectiveness and cost-effectiveness of a facilitated social network intervention to alleviate loneliness and social isolation in community settings. METHODS: A pragmatic, cluster-randomized controlled trial (RCT) was conducted to compare participants receiving the intervention with a wait-list control group. This trial als…

Rank97.2

Randomized controlled trial

The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.

Annals of internal medicine · 2026 · PMID 41911553

BACKGROUND: Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom. OBJECTIVE: To assess the efficacy of fluvoxamine and metformin for long COVID fatigue. DESIGN: Randomized, placebo-controlled, adaptive trial. (ClinicalTrials.gov: NCT06128967). SETTING: Outpatient sites in Brazil. PARTICIPANTS: 399 adults with fatigue persisting 90 or more days after confirmed SARS-CoV-2 infection. INTERVENTION: Participants were randomly ass…

Rank97.2

Randomized controlled trialResult signal: benefit

Effects of inspiratory muscle training on exercise capacity, muscle oxygenation and strength, physical activity, and dyspnea in patients with post-COVID-19 syndrome and pulmonary involvement: a randomized controlled triple-blinded study.

BMC pulmonary medicine · 2026 · PMID 41906071

BACKGROUND: Coronavirus disease 2019 (COVID-19) affects multiple organ systems, particularly the lungs, where hypoxemia may occur. Musculoskeletal problems, fatigue, and exercise intolerance frequently occur. The effects of inspiratory muscle strength training (IMST) have not been adequately investigated in patients with post-COVID-19. This study aimed to investigate the effects of IMST on functional exercise capacity, muscle oxygenation and strength, fatigue, and dyspnea in patients with post-COVID-19 syndrome and…

Rank97.2

Randomized controlled trialResult signal: null

Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42153520

BACKGROUND: HomeHealth is a home-based, voluntary sector service supporting older people with mild frailty to maintain independence through behaviour change. Support workers discuss the person's priorities and enable setting/achieving goals around mobility, nutrition, socialising and/or psychological well-being. AIMS: We tested clinical and cost-effectiveness of HomeHealth for maintaining independence in older people with mild frailty in a randomised controlled trial. METHODS: Design: Single-blind, parallel randomi…

Rank96.9

Randomized controlled trialResult signal: null

Dexmedetomidine for sedation during noninvasive ventilation in COVID-19 patients from the Helmet-COVID randomized clinical trial post-hoc analysis.

Scientific reports · 2026 · PMID 42103809

Dexmedetomidine may be used in patients managed by noninvasive ventilation (NIV), but its associations with intubation, mortality and health-related quality of life (HRQoL) are unclear. Thus, we aimed to assess the use of dexmedetomidine in patients with COVID-19-induced acute hypoxemic respiratory failure requiring NIV and its associations with the 28-day intubation rate, 28- and 180-day mortality rate, and HRQoL. This post-hoc study of the Helmet-COVID trial analyzed data from NIV-managed patients who did and did…

Rank96.9

Randomized controlled trial

Evaluating a Tailored Web-Based eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic: Randomized Clinical Trial.

Journal of medical Internet research · 2026 · PMID 42430132

BACKGROUND: Prostate cancer (PCa) is the most common nonskin cancer among men. Although treatments achieve excellent survival for localized PCa, long-lasting complications significantly diminish patients' quality of life (QOL) across physical, sexual, psychosocial, and general symptom domains. Because these effects also profoundly impact intimate partners, often reducing partners' QOL as much as or more than patients' QOL, supportive care must address the needs of both members of the couple. OBJECTIVE: This study e…

Rank96.9

Randomized controlled trialResult signal: null

A randomized controlled trial testing a digital intervention to promote weight loss and weight loss maintenance.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026 · PMID 41989407

OBJECTIVE: This study aimed to determine the effectiveness and cost-effectiveness of the Choosing Health program, which tailors support to an individual's weight loss and weight loss maintenance determinants among adults with overweight and obesity. METHOD: We conducted a randomized controlled trial with a nested interrupted time series within-person design. Participants (N = 288) were randomized to the Choosing Health digital intervention (n = 145) or a control group (n = 143). Intervention participants completed …

Rank96.8

Randomized controlled trialResult signal: null

The WORKWELL programme: a randomized controlled trial of job retention vocational rehabilitation for people with inflammatory arthritis.

Rheumatology (Oxford, England) · 2026 · PMID 42467833

OBJECTIVE: People with inflammatory arthritis (InfA) frequently experience work instability, absenteeism, and reduced productivity, culminating in early job loss. This study evaluated the effectiveness and cost-effectiveness of WORKWELL job retention vocational rehabilitation (JRVR) delivered by occupational therapists, compared with a control group receiving written self-help advice. METHODS: A pragmatic, multicentre randomized controlled trial was conducted across 18 UK National Health Service (NHS) Trusts. Emplo…

Rank96.7

Randomized controlled trialResult signal: null

Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 · PMID 41429349

OBJECTIVES: To report long-term clinical efficacy, safety, pharmacokinetics, immunogenicity and seroneutralization results of AZD7442 (monoclonal antibodies tixagevimab-cilgavimab) in patients hospitalized with COVID-19. METHODS: In this phase 3, double-blind, randomized, multicentre trial, hospitalized adults with PCR-confirmed SARS-CoV-2 infection were randomly assigned 1:1 to receive AZD7442 or placebo, and followed-up until day 456, with repeated blood sample collections until day 365. Clinical endpoints includ…

Rank96.6

Randomized controlled trialResult signal: null

A randomized controlled trial of adjunctive speleotherapy in asthma, COPD and long COVID.

Scientific reports · 2026 · PMID 42173973

Speleotherapy (underground climate therapy) is a non-pharmacological intervention for chronic respiratory diseases. This randomized controlled trial investigated whether a 3-week speleotherapy course (6 sessions, 2 h/week) improves respiratory outcomes in patients on standard background therapy with asthma, COPD, or Long COVID, and whether it affects blood CO2 levels. The control group did not receive speleotherapy but continued their standard therapy. A total of 208 patients (asthma: n = 107; COPD: n = 59; Long CO…

Rank96.4

Randomized controlled trialResult signal: null

Can An Innovative Physical Therapy Program Enhance Mobility in Middle-Aged and Older Veterans With Slow Walking Speed? A Randomized Controlled Trial.

Archives of physical medicine and rehabilitation · 2026 · PMID 41397627

OBJECTIVE: To investigate the efficacy of an innovative physical therapy program targeting mobility. DESIGN: Single-blinded randomized controlled trial. SETTING: Outpatient care VA regional tertiary care center. PARTICIPANTS: Community-dwelling middle-aged and older Veterans (N=150) with slow walking speed. INTERVENTIONS: Live Long Walk Strong (LLWS) is an 8-week, 10 (1-h/session) session outpatient physical therapy program. It was designed to enhance mobility by targeting impairments linked to mobility decline. It…

Rank96.2

Randomized controlled trialResult signal: null

Safety and immunogenicity of a reduced, homologous booster dose of the BNT162b2 mRNA COVID-19 vaccine: a single blind, randomized, non-inferiority follow-up trial.

Vaccine · 2026 · PMID 42398210

BACKGROUND: Reduced-dose primo-vaccination against COVID-19 demonstrated safety and immunogenicity, as evidenced by us and others. Fractional booster dosing may similarly maintain strong immunogenicity and protection while reducing reactogenicity, improving acceptability, and conserving supplies. OBJECTIVE: To evaluate the safety and humoral immunogenicity of a reduced-dose (10 μg) versus full-dose (30 μg) BNT162b2 booster in healthy adults. METHODS: In this single-blind, randomized, non-inferiority follow-up trial…

Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.