Viral infections evidence library

COVID-19

A living PubMed evidence library for SARS-CoV-2 prevention, acute COVID-19 treatment, severe disease, post-COVID conditions, and emerging variants.

PubMed only Research ranked Conflicts shown Data downloadable

Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 1,033 non-retracted PubMed-indexed records for COVID-19. The structured collection includes 7 guideline or consensus records, 114 evidence syntheses/systematic reviews/meta-analyses, and 125 randomized or phase III studies. 356 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 797 of 1,033 included records.

Engine 0.3.2 Snapshot v19 Updated 2026-10-28 Download source data · CSV

PubMed records1,033Non-retracted records included

Last 24 months356Records found by the recent-research search

High-priority evidence239Syntheses, reviews, randomized and phase III studies

Effect estimates301Machine-readable values extracted from abstracts

COI statements77.2%Coverage within PubMed records

Funding records229PMIDs with grant/funding metadata

Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years

2020

2021

2022

2023

2024

2025

871

2026

2027

Evidence composition

Study designs

Other or unclassified574

Randomized trials121

Preclinical/laboratory96

Meta-analyses71

Cohort studies47

Systematic reviews43

Prospective cohorts30

Observational studies15

Case reports12

Clinical guidelines7

Transparency

Conflict-of-interest reporting

Reported no conflicts367

COI statement present341

Not reported in PubMed record236

Declared financial/industry relationship89

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract926

Neutral/null signal56

Harm signal34

Supportive signal13

Mixed signal4

Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0

0.250.51.02.04.0

not_reported Odds Ratio · PMID 41496460 · 2026

5.45 95% CI 4.43–6.71

not_reported Odds Ratio · PMID 41496460 · 2026

7.71 95% CI 5.97–9.96

not_reported Odds Ratio · PMID 41496460 · 2026

5.32 95% CI 4.84–5.85

mortality Odds Ratio · PMID 41504189 · 2026

4.66

mortality Odds Ratio · PMID 41504189 · 2026

3.34

not_reported Odds Ratio · PMID 41571287 · 2026

1.19 95% CI 0.70–2.01

not_reported Odds Ratio · PMID 41571287 · 2026

5.48 95% CI 0.70–43.09

response Odds Ratio · PMID 41571287 · 2026

0.40 95% CI 0.17–0.97

response Odds Ratio · PMID 41571287 · 2026

0.43 95% CI 0.18–1.06

response Odds Ratio · PMID 41571287 · 2026

0.15 95% CI 0.04–0.54

response Odds Ratio · PMID 41571287 · 2026

0.12 95% CI 0.03–0.47

not_reported Odds Ratio · PMID 42420160 · 2026

0.75

not_reported Odds Ratio · PMID 42268674 · 2026

25.00

not_reported Odds Ratio · PMID 42497820 · 2026

1.65 95% CI 1.22–2.10

View extracted numerical results 60

Publication	Outcome	Measure	Reported value	Source
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026	not_reported	Odds Ratio	5.45 95% CI 4.43–6.71	PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026	not_reported	Odds Ratio	7.71 95% CI 5.97–9.96	PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026	not_reported	Odds Ratio	5.32 95% CI 4.84–5.85	PMID 41496460
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026	mortality	Odds Ratio	4.66	PMID 41504189
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026	mortality	Odds Ratio	3.34	PMID 41504189
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	1.19 95% CI 0.7–2.01	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	5.48 95% CI 0.7–43.09	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.4 95% CI 0.17–0.97	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.43 95% CI 0.18–1.06	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.15 95% CI 0.04–0.54	PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026	response	Odds Ratio	0.12 95% CI 0.03–0.47	PMID 41571287
The role of age, sex, and ethnicity in vaccine trust, and sources of information in Canada: Findings from a national survey.Human vaccines & immunotherapeutics · 2026	not_reported	Percentage Comparison	87.0percent vs 83.0percent	PMID 41640305
Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026	not_reported	Odds Ratio	0.75 p = .036	PMID 42420160
Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	25.0	PMID 42268674
Associations between maternal lipid metabolism in early pregnancy and postpartum symptoms of depression and anxiety: results from a longitudinal cohort of 266 women.Journal of psychiatric research · 2026	not_reported	Odds Ratio	1.65 95% CI 1.22–2.1	PMID 42497820
Neonatal intensive care unit admission among infants born full-term to CDC's COVID-19 Vaccine Pregnancy Registry participants: A matched cohort study.Human vaccines & immunotherapeutics · 2026	not_reported	Percentage Comparison	7.7percent vs 11.3percent	PMID 41774852
The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.Human vaccines & immunotherapeutics · 2026	hospitalization	Odds Ratio	5.5 95% CI 2.2–14.0	PMID 42246636
The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.Human vaccines & immunotherapeutics · 2026	hospitalization	Odds Ratio	3.9 95% CI 1.6–9.7	PMID 42246636
The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.Human vaccines & immunotherapeutics · 2026	hospitalization	Odds Ratio	9.3 95% CI 3.3–26.7	PMID 42246636
The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study.Clinical physiology and functional imaging · 2026	not_reported	Odds Ratio	2.0 p = 0.97	PMID 41921975
The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study.Clinical physiology and functional imaging · 2026	not_reported	Percentage Comparison	9.8percent vs 16.1percent p = 0.97	PMID 41921975
Teclistamab-based induction treatment in transplant-eligible, newly diagnosed multiple myeloma: a phase 2 trial.Nature medicine · 2026	not_reported	Odds Ratio	4.0	PMID 42350642
Teclistamab-based induction treatment in transplant-eligible, newly diagnosed multiple myeloma: a phase 2 trial.Nature medicine · 2026	not_reported	Odds Ratio	4.0	PMID 42350642
Teclistamab-based induction treatment in transplant-eligible, newly diagnosed multiple myeloma: a phase 2 trial.Nature medicine · 2026	not_reported	Odds Ratio	2.0	PMID 42350642
High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.Journal of critical care · 2026	mortality	Hazard Ratio	2.45 95% CI 1.97–3.05	PMID 42385526
Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study).Gut microbes · 2026	response	Percentage Comparison	1.2percent vs 1.6percent	PMID 42520140
Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study).Gut microbes · 2026	not_reported	Odds Ratio	0.6 95% CI 0.4–0.9 p = 0.02	PMID 42520140
Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.Human vaccines & immunotherapeutics · 2026	long COVID	Odds Ratio	2.68 95% CI 2.44–2.96	PMID 42610257
Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.Human vaccines & immunotherapeutics · 2026	long COVID	Odds Ratio	0.77 95% CI 0.64–0.93	PMID 42610257
Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	0.87 95% CI 0.74–1.02	PMID 42610257
Safety and immunogenicity of a reduced, homologous booster dose of the BNT162b2 mRNA COVID-19 vaccine: a single blind, randomized, non-inferiority follow-up trial.Vaccine · 2026	not_reported	Odds Ratio	30.0	PMID 42398210
Safety and immunogenicity of a reduced, homologous booster dose of the BNT162b2 mRNA COVID-19 vaccine: a single blind, randomized, non-inferiority follow-up trial.Vaccine · 2026	not_reported	Odds Ratio	30.0	PMID 42398210
The WORKWELL programme: a randomized controlled trial of job retention vocational rehabilitation for people with inflammatory arthritis.Rheumatology (Oxford, England) · 2026	not_reported	Odds Ratio	36.0 P = 0.53	PMID 42467833
The LTI-01-2001 phase 2a trial of intrapleural LTI-01 in patients with infected, non-draining pleural effusions.Respiratory research · 2026	not_reported	Odds Ratio	1.0	PMID 42310706
The LTI-01-2001 phase 2a trial of intrapleural LTI-01 in patients with infected, non-draining pleural effusions.Respiratory research · 2026	not_reported	Odds Ratio	1.04 P = 0.96	PMID 42310706
Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.Expert review of respiratory medicine · 2026	not_reported	Odds Ratio	0.36 p = 0.006	PMID 42261259
Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.Expert review of respiratory medicine · 2026	not_reported	Odds Ratio	0.62 p = 0.006	PMID 42261259
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026	not_reported	Risk Ratio	0.85 95% CI 0.8–0.91 p < 0.0001	PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026	not_reported	Risk Ratio	0.87 95% CI 0.79–0.96 p = 0.002	PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026	not_reported	Risk Ratio	0.93 95% CI 0.76–1.15 p = 0.14	PMID 41424145

Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage77.2%236 records have no COI statement exposed in PubMed.

Funding metadata coverage22.2%Coverage indicates whether grant/funding metadata was present, not independence or study quality.

Most frequently reported funding agencies

NHLBI NIH HHS98

NIH HHS30

NIAID NIH HHS28

NIDDK NIH HHS25

NCATS NIH HHS20

NIA NIH HHS17

Wellcome Trust14

NIGMS NIH HHS14

View records with declared financial or industry relationships 12

Clinical practice guideline for long COVID prevention and treatment.

Conflict of interest: B. Cao is a member of the European Respiratory Journal editorial board. J.B. Soriano reports grants from Linde via Hospital Universitario de La Princesa, consultancy fees from ERS and SEPAR, participation in speaking activities, advisory committees and consultancies for Air Liquide, Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, ERS, Grifols, GSK, Linde, Lipopharma, Mundipharma, Novartis, Pfizer, RiRL, Rovi, SEPAR and Takeda, a leadership role for the Spanish Network of Research in Long COVID (REiCOP), and is an Associate Editor for the European Respiratory Journal. R. Paredes reports participation in an advisory board with Pfizer, Gilead and AstraZeneca. R.A. Evans reports grants from Genentech/Roche, lecture fees from Moderna, and fees for participation on an advisory board for the UK National COVID Inquiry. M.J. Peluso reports consultancy fees from Gilead Sciences and AstraZeneca. J.D. Chalmers reports grants or contracts from AstraZeneca, Chiesi, Genentech, Gilead Sciences, GlaxoSmithKline, Insmed, Grifols, Trudell, Verona and Boehringer Ingelheim, and consulting fees from AstraZeneca, Biomx, Chiesi, CSL Behring, Expedition, GlaxoSmithKline, Insmed, Grifols, Boehringer Ingelheim, Pfizer, Sanofi/Regeneron and Zambon, and is the Chief Editor of the European Respiratory Journal. Y. Chen is the co-founder and co-chair of the RIGHT (Reporting Items for Practice Guidelines in Healthcare) working group. The remaining authors have no potential conflicts of interest to disclose.

PMID 41856572 · 2026

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Vivek Shinde, Wayne Woo, Susan Neal, Joyce S. Plested, Mingzhu Zhu, Shane Cloney-Clark, Iksung Cho, and Raburn M. Mallory are employees of Novavax, Inc. and may hold Novavax, Inc. stock. Anthony M. Marchese, Timothy S. Vincent, Louis Fries, and Greg Glenn are former employees of Novavax, Inc. and may hold Novavax, Inc. stock.

PMID 42390526 · 2026

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

JML and SAH’s institution received funding for the conduct of clinical trials from VIDO, Moderna, Pfizer and VBI. The remaining authors have no conflicts to declare.

PMID 42268674 · 2026

Immune correlates analysis in NextCOVE trial for a next-generation mRNA-1283 COVID-19 vaccine.

CM, JF, RW, SC, DE, BG, RD, HZ, and LZ are employees of Moderna, Inc., and may hold stock/stock options in the company.

PMID 42220116 · 2026

NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants.

Young reports personal fees from Astra-Zeneca, Gilead, Moderna, Pfizer and Sanofi outside the submitted work. Wang disclose that a patent (Patent No.: US 11,054,429 B1) was issued for the surrogate virus neutralisation test platform (cPass kit) used in this study, and declare royalty payment from GenScript for inventing the technology. All other authors no potential conflicts of interest.

PMID 42083894 · 2026

Exploring the experiences and perceptions of co-administration of routine vaccines in adults: Findings from an embedded qualitative study with participants and research delivery staff in the ZosterFluCov randomized controlled trial.

This work was funded by an investigator initiated grant from GSK. SR’s and VW’s time was funded by an investigator led grant from GSK. RL has received financial compensation from Sanofi for participating in a influenza vaccine advisory board in 2023 and from Astra Zeneca for a conference presentation in 2022. HS has previously received funding for investigator driven research from Moderna and funding to attend COVID-19 related advisor boards and to present at conferences from Pfizer.

PMID 41734040 · 2026

Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.

FN owns some AstraZeneca shares. FN and AS have research project support (paid to his institution, no personal fees) from Bayer, with no relation to the work reported here. All authors have completed the Unified Competing Interest form (available on request from the corresponding author) and declare: no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work.

PMID 41496460 · 2026

Safety of COVID-19 mRNA-1273 booster doses in Asian populations: A literature review of post-marketing observational studies.

All authors are employees of Moderna and may hold stock/stock options in the company: CC, AKB (Moderna, Australia); DE, VU (Moderna, Inc., USA); and PM (Moderna, Singapore).

PMID 42154963 · 2026

From discovery through emergency use to the present: Safety evaluation of the COVID-19 mRNA-1273 (Moderna) vaccine.

WS is an employee of Moderna, Inc., and may hold stock/stock options in the company.

PMID 42018766 · 2026

Hematologic adverse events following COVID-19 vaccination and revaccination in persons aged 12 and above: A Canadian Immunization Research Network study.

CB is a co-investigator on a project funded by Moderna but has not received any funding directly. AC has received research grants and support from Pfizer and GSK. AC has served on speaker bureaus and received honoraria from Pfizer, GSK, Moderna, and Sanofi. AC has also provided consulting services for Merck, GSK, Pfizer, Moderna, Innomed Pharma, and Paladin. LC’s research institution has received honoraria from Bayer, BMS-Pfizer Alliance, The Academy for Continued Advancement in Healthcare Education, Amag Pharmaceutical, LEO Pharma, Sanofi, Valeo Pharma, and Servier. LC holds a Tier 2 research Chair in Thrombosis and Anticoagulation Safety from the University of Ottawa. SS has received speaker honoraria from CSL Behring. MS has been an investigator on projects funded by GlaxoSmithKline, Merck, Moderna, Pfizer, and Sanofi-Pasteur. All funds have been paid to his institute, and he has not received any personal payments. MS is supported via a salary award from the BC Children’s Hospital Foundation. KAT has received grants to her institution from the Coalition for Epidemic Preparedness Innovations outside the submitted work. JMP’s institution has received funds from AstraZeneca for an industry-initiated study of children with RSV bronchiolitis and from Merck for an investigator-initiated study of children with pneumonia; he is also conducting a clinical trial that has received in-kind support for diagnostics from bioMe. JC received honoraria from GSK, Pfizer, AstraZeneca for consultancy work not related to this manuscript. JC holds a Tier 2 Research Chair in Immunization in People with Compromised Immunity from the University of Ottawa. AM has served on speaker bureaus and provided consulting services from Pfizer, Sanofi and Merck for work unrelated to this manuscript. All other authors do not have conflicts of interest to declare.

PMID 41848549 · 2026

Ozone therapy by rectal insufflation in long COVID syndrome: a preliminary study with thermographic evaluation and quality of life measurement.

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

PMID 42478179 · 2026

Vaccine safety for individuals receiving immune checkpoint inhibitor therapy: A narrative review of current literature and recommendations for future research.

The author has received funding from GSK and from Pfizer for observational studies unrelated to this work.

PMID 41661551 · 2026

Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026

BACKGROUND: Although the use of Traditional, Complementary, and Integrative Medicine (TCIM) interventions to treat coronavirus disease 2019 (COVID-19) is common, the effectiveness of these interventions is unclear. OBJECTIVE: To compare different TCIM interventions for the treatment of mild/moderate acute COVID-19. DATA SOURCES: EMBASE (Elsevier), Medline (OVID), VHL TCIM database, Cochrane Central, ClinicalTrials.gov, ICTRP, as of April 29th, 2025, as well as eight Chinese and four Korean databases. STUDY SELECTION: Randomized controlled trials comparing a TCIM intervention with another, the standard of care (SoC), placebo, or conventional medicine in participants with suspected, probable, …

PMID 42735469

Biosensors & bioelectronics · PMID 42772154

Treatment Options Studied in the PubMed Collection

These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.

higher-confidence evidence

COVID-19 Vaccines

105 linked PMIDs219547 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, mortality, serious adverse events, hospitalization, overall survival
Populations represented: general population; children; viral load; neutralizing antibody; immunocompromised patients; older adults
Mechanism: Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions In this Review, we therefore discuss the molecular and principles of formulation that underpin mRNA-LNP performance in hematology and oncology, including mRNA engineering, lipid nanoparticle architecture, intracellular trafficking and selective organ targeting(SORT) delivery strategies, oncology applications spanning neoantigen vaccines, tumor-microenvironment reprogramming, mRNA-encoded biologics, gene editing and combination therapy; and hematology applications including in vivo CAR-T, CAR-NK and HSPC engineering

PMID 42175918 PMID 39971395 PMID 41630128 PMID 42057741 PMID 39430717 PMID 42811742 PMID 37536364 PMID 36596943

higher-confidence evidence

COVID-19 vaccine

44 linked PMIDs122258 reported cumulative sample signal

Research status: conflicting evidence
Outcomes represented: reported clinical outcomes, adverse events, mortality, serious adverse events, overall survival
Populations represented: general population; children; older adults; severe COVID-19; older adults; neutralizing antibody
Mechanism: BACKGROUND: Using adapted COVID-19 vaccines targeting current variants in circulation is necessary for addressing the dynamic evolution of the SARS-CoV-2 virus and protecting against emerging variants RESEARCH DESIGN AND METHODS: Using a previously published, combined Markov-decision tree model adapted for Costa Rica, this study estimated the outcomes of different vaccination strategies with BNT162b2 COVID-19 mRNA vaccine, targeting various age and risk groups

PMID 42057741 PMID 39430717 PMID 42811742 PMID 37997650 PMID 42854550 PMID 41680545 PMID 40972704 PMID 42910459

moderate-confidence evidence

Spike Glycoprotein, Coronavirus

44 linked PMIDs5602 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, long COVID, viral clearance
Populations represented: general population; neutralizing antibody; viral load; long COVID; severe COVID-19; older adults; localized
Mechanism: Owing to its versatility, the presented platform is readily adaptable for sensing a wide range of biological and chemical targets The primary targets of SARS-CoV-2 are lung cells, where viral-host interactions trigger extensive molecular and structural changes

PMID 35720389 PMID 42908321 PMID 42431433 PMID 42501923 PMID 42721513 PMID 42302372 PMID 42361718 PMID 42702742

higher-confidence evidence

Antibodies, Viral

42 linked PMIDs7315 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, long COVID
Populations represented: general population; neutralizing antibody; viral load; long COVID
Mechanism: Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions In subsequent cVNT assays, MR17 showed a significantly higher neutralization titer against XBB.1.5 than against the Wuhan reference strain, whereas Sb14 showed comparable titers against both targets

PMID 35742506 PMID 36284331 PMID 34260780 PMID 35880305 PMID 35720389 PMID 42800087 PMID 42084498 PMID 42431433

moderate-confidence evidence

spike protein, SARS-CoV-2

38 linked PMIDs1602 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, long COVID, viral clearance
Populations represented: general population; neutralizing antibody; viral load; long COVID; severe COVID-19; older adults; localized
Mechanism: Owing to its versatility, the presented platform is readily adaptable for sensing a wide range of biological and chemical targets This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome

PMID 35720389 PMID 42908321 PMID 42431433 PMID 42501923 PMID 42721513 PMID 42361718 PMID 42492714 PMID 42580642

moderate-confidence evidence

Antibodies, Neutralizing

26 linked PMIDs5337 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, long COVID, mortality
Populations represented: general population; neutralizing antibody; viral load; long COVID
Mechanism: In subsequent cVNT assays, MR17 showed a significantly higher neutralization titer against XBB.1.5 than against the Wuhan reference strain, whereas Sb14 showed comparable titers against both targets SARS-CoV-2 infection elicits both neutralizing and non-neutralizing monoclonal antibodies (mAbs), primarily targeting to the N-terminal domain (NTD), receptor-binding domain (RBD), and S2 subunit of the spike protein

PMID 36284331 PMID 42800087 PMID 42492714 PMID 42545256 PMID 42423335 PMID 41666181 PMID 42720299 PMID 42165235

limited evidence

Antiviral Agents

25 linked PMIDs188 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality, adverse events, hospitalization
Populations represented: general population; severe COVID-19; moderate COVID-19; viral load; neutralizing antibody; advanced; older adults
Mechanism: Favipiravir, an antiviral that inhibits viral RNA-dependent RNA polymerase, has demonstrated promise as a therapeutic for RNA viral infections such as SARS-CoV-2 The results showed that the inhibition of E. coli culturability and the induction of the VBNC state by Ritonavir initially increased and then decreased with increasing concentration

PMID 42762112 PMID 42931159 PMID 42935435 PMID 42939663 PMID 42397149 PMID 42944010 PMID 42702742 PMID 42455170

preliminary evidence

Biomarkers

24 linked PMIDs12004 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, long COVID, mortality, hospitalization, adverse events, serious adverse events, mechanical ventilation
Populations represented: general population; long COVID; severe COVID-19; older adults; long COVID; C-reactive protein; severe COVID-19; C-reactive protein; children
Mechanism: Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome

PMID 42826315 PMID 42837503 PMID 42551562 PMID 41263641 PMID 42361718 PMID 42819372 PMID 41143394 PMID 39011971

moderate-confidence evidence

Influenza Vaccines

16 linked PMIDs69076 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization
Populations represented: general population; older adults; advanced; children
Mechanism: Co-administration of vaccines targeting multiple respiratory pathogens may enhance coverage and streamline adult immunization programs

PMID 41734040 PMID 40972704 PMID 41566821 PMID 42493825 PMID 42944074 PMID 42916611 PMID 42904667 PMID 41627968

limited evidence

RNA, Viral

14 linked PMIDs135 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality
Populations represented: general population
Mechanism: This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome Here we show a chip-based visual detection strategy for one or two viral RNA targets that involves only sample loading, without further instrumentation or manual actuation

PMID 42944061 PMID 42734806 PMID 42361718 PMID 42946710 PMID 42594724 PMID 40586311 PMID 39011971 PMID 34854101

moderate-confidence evidence

BNT162 Vaccine

13 linked PMIDs6150 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization
Populations represented: general population; neutralizing antibody; severe COVID-19; older adults
Mechanism: Heterologous BNT162b2 vaccination induced S1 seroconversion and detectable neutralizing antibody and T cell responses in all boosted participants, without safety concerns In a nested case-control analysis, we compared pre-infection live-virus KP.3.3-neutralizing antibody titers between cases and 1: 1 propensity-score matched controls

PMID 42661284 PMID 42800087 PMID 42118165 PMID 42700749 PMID 42430326 PMID 41848549 PMID 42878689 PMID 42879903

moderate-confidence evidence

Vaccines, Synthetic

12 linked PMIDs5453 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: serious adverse events, adverse events, reported clinical outcomes
Populations represented: general population; neutralizing antibody; severe COVID-19; older adults
Mechanism: Humoral and cellular immune responses were measured for up to one year using SARS-CoV-2-specific IgG, neutralizing antibody assays against D614G, Omicron BA.1, and XBB.1.5, cytokine secretion, and activation-induced marker (AIM) assays Both doses elicited robust binding and neutralizing antibody responses, including cross-neutralization of Omicron variants, and durable Th1-biased cellular immunity

PMID 41627968 PMID 42647564 PMID 42268674 PMID 42155675 PMID 42811742 PMID 42402151 PMID 42423335 PMID 42735873

limited evidence

Immunoglobulin G

12 linked PMIDs552 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events
Populations represented: general population; neutralizing antibody
Mechanism: Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Humoral and cellular immune responses were measured for up to one year using SARS-CoV-2-specific IgG, neutralizing antibody assays against D614G, Omicron BA.1, and XBB.1.5, cytokine secretion, and activation-induced marker (AIM) assays

PMID 35742506 PMID 42800087 PMID 42084498 PMID 42184776 PMID 42118165 PMID 34850404 PMID 41605700 PMID 34766646

limited evidence

Angiotensin-Converting Enzyme 2

12 linked PMIDs— reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes
Populations represented: general population; severe COVID-19
Mechanism: Mechanistically, the negative regulation between ENaC and ACE2 was weakened by Lut, which exhibited the efficacy against pulmonary edema through ENaC upregulation, thus improving the damaged airway surface liquid height and short-circuit current during Omicron infection CONCLUSION: Lut ameliorated Omicron-induced pulmonary edema by targeting ACE2 to restore ENaC-mediated sodium transport balance, offering a novel therapeutic strategy for treating COVID-19 related respiratory disorders

PMID 42501923 PMID 42659704 PMID 42397149 PMID 42455170 PMID 34914115 PMID 42782103 PMID 42919422 PMID 42720299

limited evidence

Coronavirus Nucleocapsid Proteins

11 linked PMIDs135 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, viral clearance
Populations represented: general population; neutralizing antibody; localized
Mechanism: Owing to its versatility, the presented platform is readily adaptable for sensing a wide range of biological and chemical targets This review provides a comprehensive overview of recent advances in nucleic acid- and antibody-based bioelectrochemical detection strategies for SARS-CoV-2, targeting the nucleocapsid (N) protein, spike (S) protein, the receptor binding domain (RBD) antigens and the viral RNA genome

PMID 42944061 PMID 42721513 PMID 42361718 PMID 42570816 PMID 34877674 PMID 34904253 PMID 42708611 PMID 42720299

limited evidence

Cytokines

10 linked PMIDs222 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events
Populations represented: general population; older adults
Mechanism: Mechanistically, depletion of mononuclear phagocytes or blockade of T-cell co-stimulation prevented the development of persistent mechanical hypersensitivity, supporting a role for coordinated innate and adaptive immune mechanisms in the establishment of long-lasting nociceptive sensitization

PMID 34260780 PMID 42315918 PMID 42944032 PMID 42580642 PMID 42685505 PMID 42503016 PMID 42836482 PMID 41533733

limited evidence

ACE2 protein, human

10 linked PMIDs— reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes
Populations represented: general population; severe COVID-19
Mechanism: Future research should prioritize mechanistic validation and conduct integrated experimental and clinical investigations to establish AMPK-ACE2 co-targeting as a viable therapeutic strategy for mitigating cardiometabolic disease burden and enhancing resilience against viral infections These insights contribute to a deeper understanding of SARS-CoV-2-host interactions and may guide future therapeutic development targeting viral entry mechanisms

PMID 42501923 PMID 42397149 PMID 42455170 PMID 34914115 PMID 42782103 PMID 42919422 PMID 42720299 PMID 42941771

limited evidence

RNA, Messenger

8 linked PMIDs2092 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes
Populations represented: general population; localized
Mechanism: In this Review, we therefore discuss the molecular and principles of formulation that underpin mRNA-LNP performance in hematology and oncology, including mRNA engineering, lipid nanoparticle architecture, intracellular trafficking and selective organ targeting(SORT) delivery strategies, oncology applications spanning neoantigen vaccines, tumor-microenvironment reprogramming, mRNA-encoded biologics, gene editing and combination therapy; and hematology applications including in vivo CAR-T, CAR-NK and HSPC engineering Preclinical and clinical studies now demonstrate potent and durable immune responses elicited by LNP-mRNA vaccines against diverse viral, bacterial, and cancer targets

PMID 35538060 PMID 36284331 PMID 42888436 PMID 41962202 PMID 42915664 PMID 42937890 PMID 39651917 PMID 35527294

Conflicting Research

higher-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

90 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 83harm: 3benefit: 1null: 3

PMID 42175918 PMID 39971395 PMID 42904667 PMID 41630128 PMID 42057741 PMID 42220116 PMID 39430717 PMID 42833101 PMID 42390526 PMID 41627968

higher-confidence evidence

COVID-19 vaccine · multiple reported outcomes

44 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 40null: 2harm: 2

PMID 34862617 PMID 42057741 PMID 42220116 PMID 39430717 PMID 42700749 PMID 42647564 PMID 42811742 PMID 37997650 PMID 42854550 PMID 41680545

higher-confidence evidence

Antiviral Agents · multiple reported outcomes

22 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 20benefit: 1mixed: 1

PMID 40067859 PMID 34837230 PMID 42925259 PMID 42316440 PMID 42762112 PMID 42931159 PMID 42935435 PMID 42939663 PMID 42397149 PMID 42944010

higher-confidence evidence

Biomarkers · multiple reported outcomes

19 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 17null: 1benefit: 1

PMID 33636985 PMID 42580608 PMID 42681987 PMID 42420160 PMID 42641144 PMID 42823695 PMID 42826315 PMID 42837503 PMID 42551562 PMID 42890148

moderate-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

6 studies

Status: apparently conflicting; different clinical questions. Population: children. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 4harm: 1null: 1

PMID 36102702 PMID 42053343 PMID 42223472 PMID 41814863 PMID 42535943 PMID 42027105

moderate-confidence evidence

remdesivir · multiple reported outcomes

6 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 5mixed: 1

PMID 40067859 PMID 42316440 PMID 42937280 PMID 42455170 PMID 42385347 PMID 34897729

preliminary evidence

Vitamin D · multiple reported outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 2null: 1harm: 1

PMID 36184196 PMID 35004568 PMID 42681987 PMID 42942120

moderate-confidence evidence

Adenosine Monophosphate · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 2mixed: 1

PMID 40067859 PMID 42316440 PMID 42455170

moderate-confidence evidence

Alanine · multiple reported outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 1mixed: 1

PMID 40067859 PMID 42316440

Failed or Negative Trials

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial.

randomized controlled trial · 2026 · PMID 42616612

Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID19: a multicenter, randomized, double-blind, placebo-controlled study.

randomized controlled trial · 2026 · PMID 42261259

Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study.

randomized controlled trial · 2026 · PMID 42848780

Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial.

randomized controlled trial · 2026 · PMID 42098760

Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial.

randomized controlled trial · 2026 · PMID 42449426

Effectiveness of polyhexanide, chlorhexidine with neomycin and mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation: non-inferiority RCT (TIDE).

randomized controlled trial · 2026 · PMID 41773476

Impact of eccentric exercise on walking functional capacity after severe COVID-19: randomized, controlled open-label trial.

randomized controlled trial · 2026 · PMID 42019312

A pragmatic randomized controlled trial of self-directed online writing interventions for posttraumatic stress symptoms in a real-world digital setting.

randomized controlled trial · 2026 · PMID 42635256

Dissociation between humoral and multi-omic immune responses to inactivated COVID-19 vaccination in patients with pulmonary tuberculosis.

randomized controlled trial · 2026 · PMID 42827549

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

randomized controlled trial · 2026 · PMID 42370465

Emerging and Experimental Research

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

preclinical or laboratory · 2027 · PMID 42424692

Piperine: From Green Extraction to Clinical Translation-A Review.

preclinical or laboratory · 2026 · PMID 42800936

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

randomized controlled trial · 2026 · PMID 42390526

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

randomized controlled trial · 2026 · PMID 41627968

Safety and immunogenicity of an mRNA COVID-19 vaccine administered to adults: A phase 2, randomized, active-controlled trial.

randomized controlled trial · 2026 · PMID 42647564

The α2-Subunit Preferring GABA Positive Allosteric Modulator, N-Desmethyl-Clobazam in Peripheral Neuropathic Pain Patients: Results of a Phase IIa Randomised Placebo-Controlled Ascending Dose Study.

randomized controlled trial · 2026 · PMID 42886059

Losartan with add-on spironolactone for severe COVID-19 in the intensive care unit: a randomized controlled trial.

randomized controlled trial · 2026 · PMID 42790654

Safety, Tolerability, and Pharmacokinetics of EGT710, a Novel Coronavirus Mpro Inhibitor, in Healthy Adults: A Randomized, Single- and Multiple-Dose Study.

randomized controlled trial · 2026 · PMID 42925259

Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas.

randomized controlled trial · 2026 · PMID 42341302

Muscle mass gain and strength recovery after discharge of critical COVID-19 patients treated with mesenchymal stromal cell infusion: a randomized clinical trial.

randomized controlled trial · 2026 · PMID 42233282

Evidence Gaps

Detailed risk-of-bias assessment remains limited

PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.

Complete Ranked PubMed Index

The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.

Current Standard Of Care92 records

Rank112.0

Clinical guideline or consensus statement

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026 · PMID 41856572

Rank110.0

Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19 Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41739597

Rank110.0

Clinical guideline or consensus statement

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41920901

Rank110.0

Clinical guideline or consensus statement

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766598

Rank110.0

Clinical guideline or consensus statement

IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal COVID-19, Influenza, and RSV Infections in Immunocompromised Patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41766454

Rank110.0

Clinical guideline or consensus statement

CAR/BRC Recommendations for Management of Axillary Lymphadenopathy Following COVID-19 Vaccination.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes · 2026 · PMID 42175918

Rank107.3

Systematic review or meta-analysis

Blood Biomarkers of Long COVID: A Systematic Review.

Molecular diagnosis & therapy · 2024 · PMID 39103645

BACKGROUND: Long coronavirus disease (COVID; LC) affects millions of people worldwide. The exact mechanisms which result in a broad, undulating and detrimental symptom profile remain unknown. Blood biomarkers associated with LC have been described; however, consensus on these remains elusive, in part due to a lack of continuity between studies on a universally accepted definition of LC. This systematic review aimed to consolidate current knowledge of blood biomarkers associated with the prevalence of LC on the basi…

Rank105.0

Systematic review or meta-analysis

Nebulized Heparin in Adults With Acute Respiratory Failure: A Meta-Analysis of Randomized Trials.

Critical care medicine · 2026 · PMID 42148826

OBJECTIVES: Dysregulated pulmonary coagulation and inflammation is a hallmark of respiratory failure in various etiologies. Excessive fibrin deposition contributes to alveolar collapse, impaired gas exchange, and progression to pulmonary fibrosis. Nebulized heparin can mitigate these coagulation and inflammation disturbances. Although several randomized controlled trials have explored its effects, results remain inconsistent and limited by small patient populations. We conducted a random-effects meta-analysis to ca…

Rank101.0

Systematic review or meta-analysis

Healthcare system disruption across WHO-declared PHEICs: a 4S comparative case analysis.

Frontiers in public health · 2026 · PMID 42807059

OBJECTIVES: To compare documented patterns of healthcare-system disruption and response across WHO-declared Public Health Emergencies of International Concern (PHEICs) using the established 4S surge-capacity framework (Staff, Stuff, Space, Systems) and an author-developed 12-indicator operationalization. METHODS: We conducted a structured comparative case analysis, not a systematic review of intervention effects, of all eight PHEIC events declared by WHO through 31 March 2026. The unit of analysis was the event, an…

Rank100.0

Systematic review or meta-analysis

Cost-Effectiveness of Virtual Emergency Care Models: Systematic Review.

JMIR mHealth and uHealth · 2026 · PMID 42555953

BACKGROUND: Virtual care technologies have rapidly expanded in emergency medicine, particularly following the COVID-19 pandemic. However, comprehensive economic evaluations of their cost-effectiveness remain fragmented across different clinical applications and health care settings, creating uncertainty for policymakers and health care administrators considering implementation. OBJECTIVE: This study aimed to systematically review and synthesize evidence on the cost-effectiveness of virtual emergency care models com…

Rank97.0

Systematic review or meta-analysis

SARS-CoV-2 infection and spontaneous spinal hemorrhage: a systematic review.

Neurosurgical review · 2023 · PMID 37966587

The neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including spontaneous spinal hemorrhage (SSH), are diverse. SSH is a detrimental neurosurgical event requiring immediate medical attention. We aimed to investigate the association between SARS-CoV-2 and SSH and delineate a rational clinical approach. The authors searched PubMed, Scopus, Web of Science, and Google Scholar for studies published up to January 25, 2023, on SSH and SARS-CoV-2 infection. For each da…

Rank96.0

Systematic review or meta-analysis

Workforce shortages and supported access to medical care for hospital employees: a scoping review.

BMJ open · 2026 · PMID 42392626

OBJECTIVES: This scoping review synthesises peer-reviewed and grey literature on supported access to medical care for hospital employees with existing physical health complaints to understand how it may reduce sickness absenteeism by promoting sustainable employability and to identify gaps and opportunities to inform the design and implementation of organisational supported care frameworks. DESIGN: We conducted this scoping review following the Arksey and O'Malley framework and Levac et al's methodological recommen…

Rank96.0

Systematic review or meta-analysis

Single reviewer assessments of certainty of evidence in network meta-analyses probably do not mislead decision-makers: a case study.

Journal of clinical epidemiology · 2026 · PMID 42551807

BACKGROUND: Systematic reviews with network meta-analyses (NMA) are the most comprehensive form of evidence synthesis for informing evidence-based practice recommendations. Rating the certainty of evidence (CoE) is a crucial step for drawing appropriate NMA's conclusions, but it can be time-consuming. OBJECTIVES: To evaluate the disagreements of assessments by a single reviewer (novice or expert) v consensus among two reviewers on CoE ratings of NMA used to support practice recommendations. METHODS: We conducted a …

Rank93.0

Systematic review or meta-analysis

Recommended operating room practice during the COVID-19 pandemic: systematic review.

BJS open · 2020 · PMID 32395909

BACKGROUND: The COVID-19 pandemic poses a critical global public health crisis. Operating room (OR) best practice in this crisis is poorly defined. This systematic review was performed to identify contemporary evidence relating to OR practice in the context of COVID-19. METHODS: MEDLINE was searched systematically using PubMed (search date 19 March 2020) for relevant studies in accordance with PRISMA guidelines. Documented practices and guidance were assessed to determine Oxford Centre for Evidence-Based Medicine (…

Rank89.5

Randomized clinical study

Clinical checklists of multicomponent non-pharmacological interventions for delirium management in adult patients in non-ICU inpatient healthcare settings: a rapid review.

BMJ open · 2026 · PMID 42366006

OBJECTIVES: To identify clinical checklists of multicomponent non-pharmacological interventions for the prevention and treatment of delirium used in non-intensive care unit inpatient healthcare settings, their content and reported implementation. DESIGN: Rapid review. DATA SOURCES: Medline, Embase, PsycINFO, CINAHL and Cochrane CENTRAL were searched from 1 January 1999 to 31 March 2022 and updated on 16 January 2025. A comprehensive grey literature search, including websites of guideline development groups and inte…

Rank87.5

Randomized clinical study

Duplex Ultrasound Surveillance after Endovascular Therapy for Peripheral Arterial Disease: A Retrospective Cohort Study.

Annals of vascular surgery · 2026 · PMID 42364765

BACKGROUND: Postoperative duplex ultrasound (DUS) surveillance is common practice globally, yet there is limited evidence to demonstrate its efficacy. This study aimed to determine the incidence of adverse events in a contemporary cohort of patients undergoing post endovascular therapy DUS surveillance and to inform the design of a planned randomized controlled trial. METHODS: A retrospective cohort study was conducted at Prince of Wales Hospital, Sydney, Australia. We reviewed consecutive patients who underwent en…

Rank87.0

Randomized clinical study

REenergizeME: intermittent hypoxia-hyperoxia treatment for myalgic encephalomyelitis/chronic fatigue syndrome-protocol for a randomised, placebo-controlled trial.

BMJ open · 2026 · PMID 42601095

INTRODUCTION: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, disabling condition characterised by post-exertional malaise (PEM), autonomic dysfunction and markedly reduced quality of life. Its prevalence has increased following the COVID-19 pandemic, yet no effective disease-modifying treatments are available and underlying mechanisms remain unclear. Evidence implicates immune-metabolic dysregulation, impaired energy metabolism, vascular dysfunction and altered oxygen handling. Intermitte…

Rank85.0

Randomized clinical study

Utilizing an explanatory case method approach to explore alternative recruitment strategies for a longitudinal randomized clinical trial of insomnia treatment in cancer survivors amid COVID-19.

PloS one · 2025 · PMID 40768530

COVID-19 was a barrier to meeting recruitment goals in clinical trials particularly for behavioral interventions requiring innovative and evolving strategies. This paper explores recruitment approaches prior to, during, and after the in-person recruitment pause in a longitudinal randomized controlled trial (RCT) in which cancer survivors received one of two interventions to self-manage insomnia. An explanatory case study method was used to investigate pre, during, and post COVID-19 recruitment during a longitudinal…

Rank73.0

Multicenter clinical study

Structured, expert-informed selection and harmonization of patient-reported outcome measures (PROMs) in a German multicenter network: the post-COVID syndrome use case.

Health and quality of life outcomes · 2026 · PMID 42791580

BACKGROUND: Patient-reported outcome measures (PROMs) provide subjective information on symptoms, functional ability or quality of life. In post-COVID syndrome (PCS), lacking clear diagnostic criteria or biomarkers, PROMs enable a differentiated assessment of disease course and treatment effects. Within a multicenter research project (EMOPROM LCN), a structured selection process for PROMs was conducted to reach consensus on a validated PROMs battery for PCS, suitable for studies and clinical care, and transferable …

Rank55.0

Other PubMed-indexed publication

Resident Exposure to Acutely Ill Patients Over the Course of Residency.

The western journal of emergency medicine · 2026 · PMID 42900943

INTRODUCTION: Emergency medicine literature has long debated the "black cloud" and "white cloud" phenomena, which suggest individual variability in exposure to acutely ill patients. If true, this variation may have significant implications for resident training. This study investigates whether emergency medicine (EM) residents consistently encounter differing volumes of high-acuity clinical encounters throughout their training. METHODS: This retrospective cohort study analyzed 11 years of electronic health record (…

Rank52.9

Other PubMed-indexed publication

Kinetics of anti-Aspergillus spp. IgG antibodies in COVID-19-associated pulmonary aspergillosis.

Medical mycology · 2026 · PMID 42667380

COVID-19-associated pulmonary aspergillosis (CAPA) is a recognized fungal superinfection, but diagnosis remains difficult due to non-specific clinical and radiological findings. While anti-Aspergillus spp. IgG antibodies (AspAb) are used for chronic aspergillosis diagnosis, their role in this context is unclear. We described AspAb kinetics in CAPA patients hospitalized in intensive care unit (ICU). We performed a retrospective study at Lille University Hospital from February 2020 to December 2021, enrolling ICU SAR…

Rank52.0

Other PubMed-indexed publication

Consensus Classification of Brain Injury Predicts Long-Term Neurodevelopmental Outcomes in Neonates With Hypoxic-Ischemic Encephalopathy.

Pediatric neurology · 2026 · PMID 42537572

BACKGROUND: Accurate early prognostication in neonatal hypoxic-ischemic encephalopathy is vital for family counseling and early interventions. This study evaluated the predictive value of the Canadian standardized magnetic resonance imaging (MRI) classification system for long-term neurodevelopmental outcomes in neonates treated with therapeutic hypothermia. METHODS: A retrospective cohort study of 172 neonates with moderate-to-severe hypoxic-ischemic encephalopathy who received therapeutic hypothermia (2014-2020) …

Diagnosis And Screening191 records

Rank106.1

Systematic review or meta-analysis

The post-acute effects of COVID-19 are not associated with robust long-term regional or global brain volumetric changes: A Bayesian meta-analytic evidence.

Neuroscience and biobehavioral reviews · 2026 · PMID 42767409

Acute respiratory and systemic manifestations associated with SARS-CoV-2 infection have been extensively investigated, including their potential effects on brain structure. However, whether structural magnetic resonance imaging (MRI) studies converge towards reproducible long-term neuroanatomical alterations following COVID-19 remains unclear, mostly due to high variability in methods and reported results across neuroimaging investigations. The present study applied a Bayesian meta-analytic approach to quantify the…

Rank102.6

Systematic review or meta-analysis

Performance of self-performed SARS-CoV-2 rapid antigen test: a systematic review and meta-analysis.

Frontiers in public health · 2024 · PMID 39494084

BACKGROUND: The aim of this study was to investigate the accuracy of self-tested SARS-CoV-2 rapid antigen tests. METHODS: Databases of Pubmed, Embase, and Cochrane Library were searched for original studies investigating accuracy of self-tested SARS-CoV-2 rapid antigen tests, with RT-PCR as "gold standard." RESULTS: Forty-five eligible studies were found after database searching and screening using pre-defined criteria. The accuracy results from 50,897 suspected COVID-19 patients were pooled, and the overall sensit…

Rank102.3

Systematic review or meta-analysis

A systematic review of acute telogen effluvium, a harrowing post-COVID-19 manifestation.

Journal of medical virology · 2022 · PMID 34931698

This systematic review focuses on the clinical features, physical examination findings, outcomes, and underlying pathology of acute telogen effluvium (TE), a type of diffuse hair loss, occurring in coronavirus disease 2019 (COVID-19) recovered patients. MEDLINE/PubMed and Embase databases were queried till October 2021 to identify studies reporting acute TE occurring after COVID-19 recovery. Data were obtained from 19 studies, which included 465 patients who were diagnosed with acute TE. The median age of these pat…

Rank100.7

Systematic review or meta-analysis

Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID-19 vaccine.

Journal of medical virology · 2022 · PMID 34862617

To analyze the clinical presentation and outcomes of myocarditis after administration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccine. Nine case series and 15 case reports (74 patients) of myocarditis after administration of the BNT162b2 or mRNA-1273 vaccine were reviewed from PubMed, Scopus, Embase, and Web of Science. We analyzed clinical manifestations, diagnostic findings, and outcomes. In addition, we performed a pooled analysis and investigated risk factors lea…

Rank100.0

Systematic review or meta-analysisResult signal: harm

Association of COVID-19 infection and the risk of new incident diabetes: a systematic review and meta-analysis.

Frontiers in endocrinology · 2024 · PMID 39253580

BACKGROUND: As the world population recovers from the COVID-19 infection, a series of acute sequelae emerge including new incident diabetes. However, the association between COVID-19 infection and new incident diabetes is not fully understood. We purpose to determine the risk of new incident diabetes after COVID-19 infection. METHODS: PubMed, Embase, and Cochrane Library were used as databases to search for cohort studies published from database inception to February 4, 2024. Two reviewers independently conducted t…

Rank100.0

Systematic review or meta-analysis

suPAR as a circulating inflammatory biomarker: time for translation into clinical practice - A systematic review.

Clinica chimica acta; international journal of clinical chemistry · 2027 · PMID 42580608

Urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor composed of three homologous domains (DI, DII, and DIII), forming a flexible structure that mediates interactions with multiple ligands. Through these interactions, uPAR plays a key role in extracellular matrix (ECM) remodeling, cell invasion, proliferation, and migration, making it a promising therapeutic target in various diseases. In addition to its membrane-bound form, uPAR can be released…

Rank98.6

Systematic review or meta-analysis

Systematic review of amino acid profiles among COVID-19 patients caused by SARS-CoV-2.

Journal of diabetes and metabolic disorders · 2026 · PMID 42491141

BACKGROUND: Emerging evidence highlights the critical role of amino acid metabolism in the pathogenesis and severity of COVID-19. This review included studies encompassing patients with varying degrees of disease severity, from mild to critical cases. METHODS: A systematic review following PRISMA guidelines was conducted, and study quality was appraised using the Newcastle-Ottawa tools to explore the relationship between amino acid profiles and clinical outcomes in COVID-19 patients. A comprehensive search of PubMe…

Rank97.8

Randomized controlled trial

Patients with MASH experience worse health-related quality of life: a multinational real-world study using LiverMultiScan.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026 · PMID 42911297

PURPOSE: Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), is increasing globally. Assessment of health-related quality of life (HRQoL), alongside non-invasive tests (NITs), may support identification of patients requiring closer clinical management. This multinational real-world randomised controlled trial evaluated associations between HRQoL (using the EQ-5D) and multiparametric MRI (mpMRI) markers of l…

Rank96.2

Randomized controlled trialResult signal: null

Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk Factor: A Randomized Trial.

Journal of the American Heart Association · 2026 · PMID 42622217

BACKGROUND: Individuals residing in the southeastern United States experience disproportionately worse stroke outcomes. Although blood pressure (BP) reduction is among the most effective strategies for improving stroke outcomes, fewer than one third of survivors of stroke achieve BP control within 1 year of the index event. METHODS: The PACESETTER (Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk Factor) trial enrolled patients with stroke and uncontrol…

Rank92.0

Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 · PMID 42420160

OBJECTIVES: The PRIME randomized trial demonstrated improved neonatal outcomes using biomarker-guided risk stratification to target interventions to pregnancies at higher risk of preterm birth (PTB). This subgroup analysis evaluated its effectiveness in nulliparous pregnancies, a population with higher baseline risk and limited obstetric history to inform risk assessment. METHODS: PRIME (NCT04301518) was a 19‑center randomized controlled trial evaluating a screen‑guided care strategy using the IGFBP4/SHBG biomarker…

Rank85.0

Randomized clinical study

Beyond Neuroinflammation: Targeting the Microbe-Barrier-Brain Axis Through Precision Nutrition in Neurological Long COVID (Neuro-PASC).

Nutrients · 2026 · PMID 42942991

Post-acute Neurological Sequelae of SARS-CoV-2 infection (Neuro-PASC) contribute substantially to Long COVID-related disability, with cognitive impairment, chronic fatigue, dysautonomia, and neuropsychiatric symptoms among its most debilitating manifestations. Although its pathogenesis remains incompletely understood, evidence implicates persistent immune activation, intestinal barrier dysfunction, microbiota dysbiosis, microbiome-derived metabolic alterations, mitochondrial dysfunction, and neuroimmune interaction…

Rank85.0

Randomized clinical study

Combined elevated C-reactive protein and detectable plasma RNA has predictive value for hospitalization during an outpatient COVID-19 convalescent plasma clinical trial.

Journal of clinical virology plus · 2026 · PMID 42877651

BACKGROUND: Laboratory biomarkers that predict progression from mild COVID-19 to hospitalization are not well defined. OBJECTIVE: To evaluate the performance of C-reactive protein (CRP) and plasma SARS-CoV-2 RNA for predicting hospitalization among mild COVID-19 outpatients enrolled in a randomized controlled trial of COVID-19 convalescent plasma (CCP). METHODS: CRP and plasma SARS-CoV-2 RNA were measured in 487 outpatient trial participants screened before March 2021. Weighted analyses accounting for sampling prob…

Rank85.0

Randomized clinical studyResult signal: benefit

IL-6 Blockade with Clazakizumab is Associated with Low Myeloid Cell Activation and Increased Type 2 Immune Responses in Non-survivors of COVID-19.

The Journal of infectious diseases · 2026 · PMID 42937315

BACKGROUND: IL-6 inhibitors have been associated with reduced mortality in severe COVID-19 in randomized clinical trials, but the comprehensive immunological impact of IL-6 blockade in the setting of an acute viral infection is poorly understood. METHODS: To gain insight into the systemic immune response to IL-6 inhibition in COVID-19, we utilized samples from patients who participated in a randomized placebo-controlled trial of clazakizumab, a direct anti-IL-6 monoclonal antibody, in severe COVID-19 in the pre-vac…

Rank85.0

Randomized clinical study

The Canadian underage substance use prevention (CUSP) trial: Amended protocol for a hybrid effectiveness-implementation cluster randomized trial of PreVenture.

Contemporary clinical trials · 2026 · PMID 42927776

BACKGROUND: Adolescent substance use remains a significant public health concern, particularly among youth with elevated personality-based risk profiles. PreVenture is a brief, personality-targeted intervention shown to reduce substance-related behaviours in prior randomized trials. OBJECTIVE: The Canadian Underage Substance Use Prevention (CUSP) trial was designed to evaluate the effectiveness and implementation of PreVenture under routine school conditions. METHODS: CUSP is a three-arm, parallel-group, hybrid eff…

Rank85.0

Randomized clinical study

Evaluation of Potential Prognostic Biomarkers for Identifying Adults Hospitalised with COVID-19 at Increased Risk of Adverse Clinical Outcomes.

Advances in therapy · 2026 · PMID 42928084

INTRODUCTION: Elevated levels of circulating cytokines and immune cells are often observed in patients with coronavirus disease 2019 (COVID-19), some of which have been associated with disease severity and clinical outcomes across various medical interventions. We evaluated 50 biomarkers and immune cell types in blood from patients in a randomised controlled trial and hypothesised that baseline inflammatory cytokines and haematologic markers would be associated with COVID-19 severity and outcomes, and a composite b…

Rank82.1

Multicenter clinical study

An interpretable machine learning model integrating mucosal and cellular immunity to predict SARS-CoV-2 reinfection: a multicenter cohort study.

Emerging microbes & infections · 2026 · PMID 42908321

SARS-CoV-2 reinfection remains a significant public health challenge that requires accurate risk assessment across populations. Using prospectively collected data from two independent cohorts, we developed and externally validated an interpretable machine learning model for predicting symptomatic SARS-CoV-2 reinfection. The cohort comprised 1,156 adults from Wuxi and Nantong, China, with a median follow-up duration of 10 months. Reinfection occurred in 128 participants (11.1%). The model integrated eighteen clinica…

Rank79.7

Multicenter clinical study

Pandemic-Related Disruptions and Hepatocellular Carcinoma Surveillance in Safety-Net Settings.

JAMA network open · 2026 · PMID 42172025

IMPORTANCE: Pandemic-related disruptions in cirrhosis care resulted in major gaps and delays in surveillance for hepatocellular carcinoma (HCC). Whether these initial declines improved and rebounded to prepandemic levels remains unclear. OBJECTIVE: To evaluate contemporary clinical practice data on HCC surveillance utilization from before the COVID-19 pandemic to 4 years after the onset of the pandemic among safety-net populations with cirrhosis. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study wa…

Rank78.5

Multicenter clinical study

Influenza A-associated pulmonary aspergillosis in critically ill patients in the post-COVID-19 era: a multicenter cohort study from China.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42668058

BACKGROUND: To determine the incidence, risk factors, and outcomes of invasive pulmonary aspergillosis (IPA) in critically ill patients with Influenza A pneumonia in post-COVID-19 China. METHODS: We conducted a multicenter retrospective cohort study across 21 ICUs (November 2024-February 2025) including adults with acute respiratory failure due to confirmed severe Influenza A pneumonia. IPA was defined by 2024 FUNDICU criteria. The primary outcome was 60-day all-cause mortality. RESULTS: Among 542 patients, 179 (33…

Rank71.2

Prospective cohort studyCorrection flagged

Residential greenness and reduced depression during COVID-19: Longitudinal evidence from the Canadian Longitudinal Study on Aging.

PloS one · 2025 · PMID 40833944

BACKGROUND: Urban greenness has several demonstrated mental health benefits, including lower rates of depression and loneliness. Few studies have evaluated the possible benefits of greenness on depression during the COVID-19 worldwide pandemic. We investigated this topic using a prospective cohort of Canadian adults. METHODS: Our study population consisted of 13,130 participants, 50 years of age and older, of the Canadian Longitudinal Study on Aging. The Center for Epidemiological Studies Depression Short Scale (CE…

Rank70.1

Prospective cohort study

Biomarkers of Apoptosis and Systemic Inflammation in Patients with COVID-19 Undergoing Targeted Anticoagulant Therapy.

Life (Basel, Switzerland) · 2026 · PMID 42942279

BACKGROUND: We assessed apoptosis biomarkers alongside systemic inflammatory indices in patients diagnosed with COVID-19 undergoing targeted anticoagulant therapy. METHODS: A prospective cohort study involved a total of 370 patients hospitalized with COVID-19 from 2021 to 2022. One hundred ninety patients with COVID-19 received low-molecular-weight heparins, LMWH (group 1), one hundred twenty-three patients received unfractionated heparin, UFH (group 2), and fifty-seven patients received direct oral anticoagulants,…

Rank65.6

Observational or cohort studyResult signal: null

Impact of the COVID-19 pandemic on endometrial cancer diagnosis: a retrospective observational study.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026 · PMID 42921470

OBJECTIVE: To compare the prevalence of diagnostic hysteroscopies for endometrial cancer, the prevalence of endometrial cancer diagnoses, and the staging of endometrial cancer at the time of diagnosis before and during the COVID-19 pandemic. METHODS: Retrospective observational study included 631 women who underwent diagnostic hysteroscopy at a tertiary hospital in Campinas. Medical records were analyzed from two periods: two years before the COVID-19 pandemic (2018 and 2019) and two years during the pandemic (2020…

Rank60.0

Observational or cohort study

Online Information-Seeking Behaviour for Major Cancers: A 10-Year Infodemiological Study to Inform Public Health and Health Promotion Priorities in Hungary.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42930599

Background/Objectives: To analyse trends in online information-seeking behaviour for five major cancers in Hungary, compare them with global trends, and assess changes during the COVID-19 pandemic, cancer-related awareness campaigns, and major cancer-related events on search activity. Methods: A retrospective observational infodemiological study was conducted using Google Trends™ (GT) data for lung, colorectal, breast, prostate, and pancreatic cancers between 2013 and 2022. Search intensity was assessed using uncor…

Rank58.0

Other PubMed-indexed publication

Stage Migration, Treatment Patterns, and Machine Learning-Based Prediction of 12-Month Mortality in Lung Adenocarcinoma Across the COVID-19 Era: A SEER Population-Based Study.

Diagnostics (Basel, Switzerland) · 2026 · PMID 42938208

Background/Objectives: The COVID-19 pandemic coincided with widespread disruption of cancer care. We examined changes in lung adenocarcinoma presentation and outcomes across the COVID-19 era and whether diagnosis-time information identifies patients at risk of early death. Methods: Adults with microscopically confirmed lung adenocarcinoma diagnosed during 2018-2023 were identified from the Surveillance, Epidemiology, and End Results 17 Registries database and grouped into three diagnostic periods. Logistic regressi…

Rank55.0

Other PubMed-indexed publication

Evaluating Healthcare Center Staff Attitudes Toward Adoption of Tobacco-Free Policies and Concurrent Tobacco Use and Behavioral Health Treatment in Rural and Medically Underserved Areas of Texas.

Healthcare (Basel, Switzerland) · 2026 · PMID 42940527

BACKGROUND: People with behavioral health conditions (BHCs), including substance use disorders (SUDs) and mental health conditions, use tobacco at elevated rates, yet tobacco management is often overlooked during healthcare visits. Tobacco-free workplace policies (TFWPs) effectively reduce tobacco use in healthcare centers (HCs), but staff valuation is key to successful adoption. Little is known about the factors influencing staff (providers' and managers') value of TFWPs, especially in HCs serving rural or medical…

Rank53.8

Other PubMed-indexed publication

Temporomandibular Disorder-Related Symptoms and Health-Related Quality of Life among Japanese Adults.

JDR clinical and translational research · 2026 · PMID 42935443

INTRODUCTION: Temporomandibular disorders (TMDs) are among the most prevalent musculoskeletal conditions affecting the orofacial region. However, their association with preference-based health-related quality of life (HRQOL) has not been fully examined. OBJECTIVES: This study evaluated the association between TMD-related symptoms and HRQOL using a 5-level EuroQol 5-dimensional questionnaire (EQ-5D-5L) in Japanese adults. METHODS: A cross-sectional analysis was conducted using data from the Japan COVID-19 and Societ…

World journal of pediatrics : WJP · 2024 · PMID 38055113

BACKGROUND: The long-term sequelae of COVID-19 in children and adolescents remain poorly understood and characterized. This systematic review and meta-analysis sought to summarize the risk factors for long COVID in the pediatric population. METHODS: We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVID or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression analyses. Trial registries, reference list…

Rank109.1

Systematic review or meta-analysis

The Relationship Between Boredom and Smartphone Addiction Before and After the Outbreak of the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Psychological reports · 2026 · PMID 39868931

Prior research has explored the relationship between boredom and smartphone addiction (SPA), but significant discrepancies remain. Moreover, the outbreak of the COVID-19 pandemic may have altered this association. Thus, this meta-analysis aims to clarify the true relationship between boredom and SPA, while also analyzing potential moderating factors. Articles published through April 2024 were retrieved from Chinese databases (CNKI, Wanfang, VIP) and English databases (Web of Science Core Collection, PubMed, Science…

Rank109.0

Systematic review or meta-analysis

The association between ulcerative colitis and COVID-19 severity: a systematic review and meta-analysis systematic review.

International journal of colorectal disease · 2023 · PMID 38108846

PURPOSE: After the COVID-19 pandemic, many challenges arose regarding the impact of this disease on people with ulcerative colitis. The aims of this study were to estimate the prevalence, severity, and death consequences of COVID-19 in patients with ulcerative colitis using a systematic review and meta-analysis. METHODS: This study was conducted using a systematic review and meta-analysis method in the field of prevalence, severity, and clinical consequences of COVID-19 in people with ulcerative colitis worldwide. …

Rank109.0

Systematic review or meta-analysis

Molnupiravir for treating COVID-19.

The Cochrane database of systematic reviews · 2025 · PMID 41147546

RATIONALE: Five years from the start of the COVID-19 pandemic, morbidity and mortality have subsided. Vaccines have contributed to reducing the risk of infection and severe disease. However, new COVID-19 variants continue to emerge, and the role of oral antivirals such as molnupiravir in preventing progression of disease or hospitalisation must be assessed. OBJECTIVES: To assess the effects of molnupiravir in people with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mild to mo…

Rank108.5

Systematic review or meta-analysisResult signal: benefit

Traditional, complementary, and integrative medicine therapies for mild/moderate acute COVID-19: a systematic review and network meta-analysis.

Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026 · PMID 42735469

Rank108.2

Systematic review or meta-analysis

Hydroxychloroquine and COVID-19 story: is the low-dose treatment the missing link? A comprehensive review and meta-analysis.

Naunyn-Schmiedeberg's archives of pharmacology · 2024 · PMID 37639021

Hydroxychloroquine (HCQ) has been repurposed and used for the treatment of COVID-19 patients; however, its efficacy remains controversial, maybe partly due to the dosage, ranging from 200 to 800 mg/day, reported in different studies. Indeed, HCQ low dose (≤ 2.4 g/5 days) showed a lower risk of side effects compared to high doses. In this study, we performed a systematic review and meta-analysis to investigate the effect of low-dose HCQ used alone on three outcomes including in-hospital mortality, the need for mecha…

Rank108.1

Systematic review or meta-analysis

Infectious Complications in Adults Receiving Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis of Nosocomial and Bloodstream Infection, Prevalence, Risk Factors, and Clinical Outcomes.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42930572

BACKGROUND/OBJECTIVES: Reported infection rates during extracorporeal membrane oxygenation (ECMO) vary widely, partly because case definitions are applied inconsistently. We synthesized the prevalence and prognostic association of nosocomial and bloodstream infection (BSI) acquired during adult ECMO. METHODS: PubMed/MEDLINE, Embase, Scopus and CENTRAL were searched through December 2025 for observational studies of at least 10 adults on ECMO with an explicit infection definition. We classified case definitions by t…

Rank107.5

Systematic review or meta-analysisResult signal: null

Sotrovimab in the treatment of coronavirus disease-2019 (COVID-19): a systematic review and meta-analysis of randomized clinical trials.

Naunyn-Schmiedeberg's archives of pharmacology · 2024 · PMID 39031183

This study was carried out to verify the evidence regarding the effectiveness and safety of sotrovimab in patients with COVID-19. This is a systematic review of randomized clinical trials retrieved from the PubMed, Embase, Scopus, Lilacs, and Cochrane Library databases. The risk of bias was measured using the Cochrane Risk and Bias Checklist (RoB 2). For the meta-analysis, RStudio Version 2024.04.2 software was used. The certainty of evidence was assessed using GRADE. The study protocol was registered in PROSPERO (…

Rank107.3

Systematic review or meta-analysis

COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss.

Human reproduction update · 2024 · PMID 38016805

BACKGROUND: Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates are more likely to be stillborn or admitted to a neonatal unit. The World Health Organization declared in May 2023 an end to the coronavirus disease 2019 (COVID-19) pandemic as a global health emergency. However, pregnant women are still becoming infected with SARS-CoV-2 and there is limited information available regarding the effect of SARS-CoV-2 infec…

Rank107.3

Systematic review or meta-analysis

Blood Biomarkers of Long COVID: A Systematic Review.

Molecular diagnosis & therapy · 2024 · PMID 39103645

Rank107.1

Systematic review or meta-analysisResult signal: harm

Thromboprophylaxis for outpatients with COVID-19: a Systematic Review and Meta-analysis.

Journal of thrombosis and thrombolysis · 2024 · PMID 38671166

Patients with COVID-19 develop an increased risk of thromboembolism. Thromboprophylaxis is recommended for hospitalized COVID-19 patients, but the role of thromboprophylaxis in outpatients with COVID-19 is less well defined. We conducted a systematic review and meta-analysis to evaluate the safety and efficacy of thromboprophylaxis among outpatients with COVID-19. We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus from inception to August 2023. The outcomes of int…

Rank107.0

Systematic review or meta-analysis

Effectiveness of COVID-19 vaccines among children and adolescents against SARS-CoV-2 variants: a meta-analysis.

European journal of pediatrics · 2023 · PMID 37768334

This systematic review and meta-analysis aimed to evaluate the effectiveness of COVID-19 vaccines among children and adolescents against SARS-CoV-2 variants. We searched PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov for studies published on or before June 20, 2023. Studies evaluating the effectiveness of COVID-19 vaccines in children and adolescents (≤ 18 years of age) were included. Data extraction, quality assessment, and analysis were conducted following PRISMA guidelines. Ten stud…

Rank107.0

Systematic review or meta-analysis

Systematic review and meta-analysis of anti-CD20 treatments in patients with COVID-19: an assessment of severe illness and mortality outcomes.

Inflammopharmacology · 2023 · PMID 37804462

BACKGROUND: The use of anti-CD20 monoclonal antibodies, such as rituximab and ocrelizumab, has emerged as a matter of concern, in patients with coronavirus disease 2019 (COVID-19). OBJECTIVE: We aimed to summarize the overall evidence on the pre-admission/pre-diagnosis use of anti-CD20 among patients with COVID-19 with regards to mortality and severe illness outcomes. METHODS: A systematic literature search with no language restriction was performed in electronic databases, including PubMed, Google Scholar, Scopus,…

Rank106.8

Systematic review or meta-analysis

Transition of care interventions to manage severe COVID-19 in the ambulatory setting: a systematic review.

Internal and emergency medicine · 2024 · PMID 38104299

BACKGROUND: Severe COVID-19, with the need in supplemental oxygen and hospitalization, leads to major burden on patients and healthcare systems. As a result, safe and effective ambulatory treatment strategies for severe COVID-19 are of urgent need. In this systematic review, we aimed to evaluate interventions to transition care to the ambulatory setting for patients with active severe COVID-19 that required supplemental oxygen. METHODS: We searched Medline, Scopus, Web of Science, and DOAJ databases to identify art…

Rank106.8

Systematic review or meta-analysis

The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology · 2024 · PMID 39225947

INTRODUCTION: Vitamin D, known for its role in bone health, is now being explored for its immunomodulatory effects. This study aimed to evaluate the impact of vitamin D supplementation on mortality in coronavirus disease 2019 (COVID-19) patients through a systematic review and meta-analysis of randomized controlled trials. METHODS: A comprehensive search was conducted across PubMed, Scopus, Web of Science, and preprint servers for eligible trials up to July 8, 2024. Two investigators independently screened the reco…

Rank106.8

Systematic review or meta-analysisResult signal: mixed

Extended Prone Positioning in ARDS: A Systematic Review and Meta-Analysis.

Respiratory care · 2026 · PMID 41631378

BACKGROUND: Prone positioning is a recommended therapy for patients with moderate-to-severe ARDS; however, the optimal duration of this maneuver is still unknown. METHODS: We performed a systematic review and meta-analysis comparing clinical outcomes of extended (≥24 h) versus traditional prone positioning (16-24 h) of adults with moderate-to-severe ARDS receiving invasive mechanical ventilation. RESULTS: Ten studies involving 2,412 subjects met the inclusion criteria, including one randomized controlled trial and …

Rank106.6

Systematic review or meta-analysisResult signal: null

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.

Journal of rehabilitation medicine · 2026 · PMID 42895360

OBJECTIVE: To evaluate supervised physical, psycho-logical, and alternative non-pharmacological interventions for improving patient-reported and objective functional outcomes in adults with post-COVID-19 condition. DESIGN: Systematic review of randomized controlled trials. METHODS: PubMed, Web of Science Core Collection, APA PsycInfo, and Scopus were searched from 1 January 2020 to 29 January 2026. Eligible studies were supervised, face-to-face trials evaluating physical, psychological, or alternative non-pharmacol…

Rank106.2

Systematic review or meta-analysis

Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024 · PMID 38421524

Post-COVID conditions (PCCs) cover a wide spectrum of lingering symptoms experienced by survivors of coronavirus disease 2019 (COVID-19). Neurological and neuropsychiatric sequelae are common in PCCs. Advanced magnetic resonance imaging (MRI) techniques can reveal subtle alterations in brain structure, function, and perfusion that underlie these sequelae. This systematic review aimed to synthesize findings from studies that used advanced MRI to characterize brain changes in individuals with PCCs. A detailed literat…

Landmark Evidence90 records

Rank108.1

Systematic review or meta-analysis

Infectious Complications in Adults Receiving Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis of Nosocomial and Bloodstream Infection, Prevalence, Risk Factors, and Clinical Outcomes.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42930572

Rank107.9

Systematic review or meta-analysis

Persistent symptoms among post-COVID-19 survivors: A systematic review and meta-analysis.

Journal of clinical nursing · 2024 · PMID 36426658

BACKGROUND: Single studies support the presence of several post-COVID-19 symptoms; however, there is no evidence for the synthesis of symptoms. OBJECTIVE: We attempt to provide an overview of the persistent symptoms that post-COVID-19 patients encounter, as well as the duration of these symptoms to help them plan their rehabilitation. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: A total of 16 studies involving 8756 patients post-COVID-19 were included. METHODS: The CINAHL, PubMed, EMBASE, Scopus, and …

Rank107.0

Systematic review or meta-analysis

COVID-19 and healthcare workers: A systematic review and meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021 · PMID 33444754

BACKGROUND: The COVID-19 pandemic has focused attention on the challenges and risks faced by frontline healthcare workers (HCW). This study aimed to describe the clinical outcomes and risk factors for SARS-CoV-2 infection in HCW. METHODS: Three databases were surveyed and 328 articles were identified. Of these, 225 articles did not meet inclusion criteria; therefore, 97 full-text article were reviewed. Finally, after further revision, 30 articles were included in the systematic review and 28 were used for meta-anal…

Rank106.8

Systematic review or meta-analysisResult signal: mixed

Extended Prone Positioning in ARDS: A Systematic Review and Meta-Analysis.

Respiratory care · 2026 · PMID 41631378

Rank105.9

Systematic review or meta-analysis

Ischemic stroke associated with COVID-19: a systematic review and meta-analysis.

Journal of neurology · 2022 · PMID 34652503

BACKGROUND: Coronavirus disease 2019 (COVID-19), a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. Apart from respiratory complications, an increasing number of patients with ischemic stroke have been reporting. OBJECTIVE: This systematic review and meta-analysis aims to explore the characteristics of ischemic stroke after SARS-CoV-2 infection, and provides valuable reference materials for subsequent clinical treatment. MATERIALS AND…

Rank105.7

Systematic review or meta-analysisResult signal: harm

Effect of heart failure on the outcome of COVID-19 - A meta analysis and systematic review.

The American journal of emergency medicine · 2021 · PMID 33071085

BACKGROUND: Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease. PURPOSE: In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19. METHODS: We performed a systematic literature search from PubMed, EuropePMC, SCOP…

Rank105.5

Systematic review or meta-analysis

Endometriosis and COVID-19: A Systematic Review and Meta-Analysis.

International journal of molecular sciences · 2022 · PMID 36361745

Endometriosis is defined as ectopic endometrial tissues dispersed outside the endometrium. This can cause disruption in hormonal and immunological processes, which may increase susceptibility to SARS-CoV-2 infection. Worsening of endometriosis symptoms may occur as a result of this infection. The aim of our review was to estimate the pooled prevalence of SARS-CoV-2 infection and the health impacts of the COVID-19 pandemic in endometriosis patients. We conducted a systematic review and meta-analysis. MEDLINE, Scienc…

Rank104.5

Systematic review or meta-analysis

A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat SARS-CoV-2 in Hospitalized Patients: Have the Guidelines Evolved With the Evidence?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40067859

BACKGROUND: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir, a broad-spectrum antiviral. Given the evolving nature of coronavirus disease 2019, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review with meta-analysis to summarize the effectiveness of remdesivir among hospitalize…

Rank104.4

Systematic review or meta-analysis

Long-term impact of SARS-CoV-2 infection on cardiorespiratory fitness: a meta-analysis.

Frontiers in public health · 2023 · PMID 37920575

BACKGROUND: Despite surviving Coronavirus disease 2019 (COVID-19), its long-term impact is of concern. Low cardiorespiratory fitness is a strong predictor of all-cause mortality, and likely affected by multisystem impairments following COVID-19 infection. Accumulating evidence has identified the impact of COVID-19 on cardiorespiratory fitness level. However, the findings have been controversial. Conclusive evidence is still needed. OBJECTIVES: This review aimed to systematically summarize and synthesize whether the…

Rank104.2

Systematic review or meta-analysis

Cardiac Complications in COVID-19: A Systematic Review and Meta-analysis.

Archives of Iranian medicine · 2021 · PMID 33636985

BACKGROUND: The newly emerged coronavirus disease 2019 (COVID-19) seems to involve different organs, including the cardiovascular system. We systematically reviewed COVID-19 cardiac complications and calculated their pooled incidences. Secondarily, we compared the cardiac troponin I (cTnI) level between the surviving and expired patients. METHODS: A systematic search was conducted for manuscripts published from December 1, 2019 to April 16, 2020. Cardiovascular complications, along with the levels of cTnI, creatine…

Rank104.1

Systematic review or meta-analysis

Clinical efficacy and adverse events of baricitinib treatment for coronavirus disease-2019 (COVID-19): A systematic review and meta-analysis.

Journal of medical virology · 2022 · PMID 34846766

The benefits of baricitinib in coronavirus disease-2019 are inadequately defined. We performed a systematic review and meta-analysis of studies of baricitinib to determine its clinical efficacy and adverse events in patients with COVID-19. Databases were searched from their inception to September 5, 2021. The primary outcome was the coefficient of mortality. We also compared secondary indicators and adverse events between baricitinib treatment and placebo or other treatments. Twelve studies of 3564 patients were in…

Rank103.6

Systematic review or meta-analysisResult signal: harm

Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis.

Journal of endocrinological investigation · 2022 · PMID 35527294

PURPOSE: The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated. METHODS: All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male …

Rank103.0

Systematic review or meta-analysis

Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe outcomes in adults: a systematic review and meta-analysis of European studies published up to 22 January 2024.

European respiratory review : an official journal of the European Respiratory Society · 2025 · PMID 39971395

BACKGROUND: Up-to-date evidence from European studies on long-term vaccine effectiveness (VE) of COVID-19 vaccines is lacking. This review aimed to evaluate effectiveness and durability of primary vaccine series and boosters in preventing infection and severe outcomes in the European population. METHODS: We conducted systematic searches of PubMed and Embase up to 22 January 2024. We included observational studies that evaluated VE against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or sev…

Rank103.0

Systematic review or meta-analysis

Obesity in COVID-19: A Systematic Review and Meta-analysis.

Annals of the Academy of Medicine, Singapore · 2020 · PMID 33463658

Journal of medical virology · 2022 · PMID 34850411

The coagulation markers, pro-inflammatory cytokines (such as IL-2R, IL-6, IL-10, and TNF-a) and lymphopenia are associated with the severity of coronavirus disease 2019 (COVID-19) disease. The use of anti-inflammatory agents, such as corticosteroids (CS) or tosilizumab (TCZ), has been suggested for the treatment of advanced stage of COVID-19 and the reduction of mechanical ventilators and mortality. The aim of this meta-analysis is to determine the role of combination therapy with tocilizumab and steroids in COVID-…

Rank101.4

Systematic review or meta-analysis

Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta-analysis.

Journal of medical virology · 2021 · PMID 32691881

We aim to systematically review the characteristics of asymptomatic infection in the coronavirus disease 2019 (COVID-19). PubMed and EMBASE were electronically searched to identify original studies containing the rate of asymptomatic infection in COVID-19 patients before 20 May 2020. Then mate-analysis was conducted using R version 3.6.2. A total of 50 155 patients from 41 studies with confirmed COVID-19 were included. The pooled percentage of asymptomatic infection is 15.6% (95% CI, 10.1%-23.0%). Ten included stud…

Rank101.4

Systematic review or meta-analysis

Prophylaxis against covid-19: living systematic review and network meta-analysis.

BMJ (Clinical research ed.) · 2021 · PMID 33903131

UPDATES: This is the second version (first update) of the living systematic review, replacing the previous version (available as a data supplement). When citing this paper please consider adding the version number and date of access for clarity. OBJECTIVE: To determine and compare the effects of drug prophylaxis on severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (covid-19). DESIGN: Living systematic review and network meta-analysis (NMA). DATA SOURCES: World…

Rank101.3

Randomized controlled trial

Evaluating a multi-vaccine respiratory immunization strategy involving SARS-CoV-2, pneumococcal, and influenza vaccines in adults: A randomized, open-label, multicenter, controlled, non-inferiority Phase IV trial in China.

Human vaccines & immunotherapeutics · 2026 · PMID 42904667

Co-administration of vaccines targeting multiple respiratory pathogens may enhance coverage and streamline adult immunization programs. We conducted a randomized, multicentre, open-label Phase IV trial registered at Chinese Clinical Trial Registry (ChiCTR2100046227) in China to evaluate the immunogenicity and safety of co-administering an inactivated SARS-CoV-2 vaccine (WIBP-CorV) with the 23-valent pneumococcal polysaccharide vaccine (PPV23) and a quadrivalent inactivated influenza vaccine (IIV4). A total of 1,404…

Rank100.7

Systematic review or meta-analysis

Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID-19 vaccine.

Journal of medical virology · 2022 · PMID 34862617

Rank100.4

Systematic review or meta-analysis

Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis.

JAMA network open · 2020 · PMID 32525549

IMPORTANCE: Coronavirus disease 2019 (COVID-19) is a global pandemic and can involve the gastrointestinal (GI) tract, including symptoms like diarrhea and shedding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in feces. OBJECTIVE: To provide a pooled estimate of GI symptoms, liver enzyme levels outside reference ranges, and fecal tests positive for SARS-CoV-2 among patients with COVID-19. DATA SOURCES: An electronic literature search was performed for published (using MEDLINE/PubMed and Embase…

Most Effective Evidence Supported Treatments225 records

Rank110.8

Systematic review or meta-analysis

Clinical Outcomes and Complications of Extracorporeal Membrane Oxygenation (ECMO) in Adult Patients With COVID-19 in Central and Eastern Europe: A Systematic Review and Meta-Analysis.

Medical science monitor : international medical journal of experimental and clinical research · 2026 · PMID 42908181

Rank110.0

Clinical guideline or consensus statement

CAR/BRC Recommendations for Management of Axillary Lymphadenopathy Following COVID-19 Vaccination.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes · 2026 · PMID 42175918

Rank110.0

Systematic review or meta-analysis

Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.

Journal of affective disorders · 2026 · PMID 42203050

Rank110.0

Clinical guideline or consensus statementResult signal: harm

Recommendations for COVID-19 Vaccines in Infants, Children, and Adolescents, 2026-2027: Policy Statement.

Pediatrics · 2026 · PMID 42683684

Rank110.0

Clinical guideline or consensus statement

Recommendations for COVID-19 Vaccines in Infants, Children, and Adolescents, 2026-2027: Technical Report.

Pediatrics · 2026 · PMID 42683687

Rank109.0

Systematic review or meta-analysis

Molnupiravir for treating COVID-19.

The Cochrane database of systematic reviews · 2025 · PMID 41147546

Rank108.5

Systematic review or meta-analysisResult signal: benefit

Traditional, complementary, and integrative medicine therapies for mild/moderate acute COVID-19: a systematic review and network meta-analysis.

Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026 · PMID 42735469

Rank108.2

Systematic review or meta-analysis

Hydroxychloroquine and COVID-19 story: is the low-dose treatment the missing link? A comprehensive review and meta-analysis.

Naunyn-Schmiedeberg's archives of pharmacology · 2024 · PMID 37639021

Rank107.5

Systematic review or meta-analysisResult signal: null

Sotrovimab in the treatment of coronavirus disease-2019 (COVID-19): a systematic review and meta-analysis of randomized clinical trials.

Naunyn-Schmiedeberg's archives of pharmacology · 2024 · PMID 39031183

Rank107.1

Systematic review or meta-analysisResult signal: harm

Thromboprophylaxis for outpatients with COVID-19: a Systematic Review and Meta-analysis.

Journal of thrombosis and thrombolysis · 2024 · PMID 38671166

Rank107.0

Systematic review or meta-analysis

Effectiveness of COVID-19 vaccines among children and adolescents against SARS-CoV-2 variants: a meta-analysis.

European journal of pediatrics · 2023 · PMID 37768334

Rank106.8

Systematic review or meta-analysis

Transition of care interventions to manage severe COVID-19 in the ambulatory setting: a systematic review.

Internal and emergency medicine · 2024 · PMID 38104299

Rank106.8

Systematic review or meta-analysisResult signal: mixed

Extended Prone Positioning in ARDS: A Systematic Review and Meta-Analysis.

Respiratory care · 2026 · PMID 41631378

Rank106.8

Systematic review or meta-analysis

The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology · 2024 · PMID 39225947

Rank106.6

Systematic review or meta-analysisResult signal: null

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.

Journal of rehabilitation medicine · 2026 · PMID 42895360

Rank106.1

Systematic review or meta-analysis

Anticoagulants for people hospitalised with COVID-19: a rapid review.

The Cochrane database of systematic reviews · 2022 · PMID 35244208

BACKGROUND: The primary manifestation of coronavirus disease 2019 (COVID-19) is respiratory insufficiency that can also be related to diffuse pulmonary microthrombosis and thromboembolic events, such as pulmonary embolism, deep vein thrombosis, or arterial thrombosis. People with COVID-19 who develop thromboembolism have a worse prognosis. Anticoagulants such as heparinoids (heparins or pentasaccharides), vitamin K antagonists and direct anticoagulants are used for the prevention and treatment of venous or arterial…

Rank106.0

Systematic review or meta-analysis

Mesenchymal Stem Cells on Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Stem cell reviews and reports · 2024 · PMID 38427315

BACKGROUND: The Coronavirus disease-2019 (COVID-19) pandemic continues, and the death toll continues to surge. This meta-analysis aimed to determine the efficacy of mesenchymal stem cells (MSCs) on mortality in patients with COVID-19. METHODS: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on treatment of COVID-19 with MSCs, compared with placebo or blank, were reviewed. Studies were pooled to risk ratios (…

Rank106.0

Systematic review or meta-analysisResult signal: harm

Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis.

BMJ global health · 2024 · PMID 38580375

OBJECTIVE: To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Major databases between December 2019 and January 2023. STUDY SELECTION: Nine pairs of reviewers contributed to study selection. We included test-negative designs, comparative cohorts and randomised trials on effects of COVID-19 vaccines on infection-related and pregnancy outcomes. Non-c…

Rank105.8

Systematic review or meta-analysis

Effect of methotrexate hold on COVID-19 vaccine response in the patients with autoimmune inflammatory disorders: a systematic review and meta-analysis.

Clinical rheumatology · 2024 · PMID 38802670

Immunosuppressants, such as methotrexate (MTX), can suppress the COVID-19 vaccine response in patients with autoimmune diseases. Thus, this study aims to evaluate the effects of MTX hold following COVID-19 vaccination on vaccine efficacy response. A systematic review and meta-analysis of relevant studies retrieved from Web of Science, SCOPUS, PubMed, and CENTRAL from inception until Oct 1, 2023, was conducted. Covidence was used to screen the eligible articles, and all relevant outcomes data were synthesized using …

Rank105.4

Systematic review or meta-analysisResult signal: null

Effect of subcutaneous vs. intravenous tocilizumab in patients with severe COVID-19: a systematic review.

European journal of clinical pharmacology · 2024 · PMID 38926166

OBJECTIVE: To systematically evaluate the efficacy of subcutaneous tocilizumab in the treatment of patients with severe COVID-19 and provide evidence for the rational use of subcutaneous tocilizumab in patients with severe COVID-19. METHODS: This meta-analysis was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched the Cochrane Library, PubMed, Embase, CNKI, SinoMed, and Wanfang Medical Network electronic databases up to 11 January 20…

Rank104.9

Systematic review or meta-analysisCorrection flagged

Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review.

Infection · 2024 · PMID 38113020

PURPOSE: Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID. METHODS: MEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to July 15th, 2023. Articles comparing the presence of long-COVID symptoms between individuals who receive…

Rank104.7

Systematic review or meta-analysis

Long-term renal outcomes of patients with COVID-19: a meta-analysis of observational studies.

Journal of nephrology · 2023 · PMID 37787893

BACKGROUND: Kidney involvement is common in hospitalized coronavirus disease 2019 (COVID-19) patients during the acute phase, little is known about the long-term impact of COVID-19 on the kidney. METHODS: This is a systematic review and meta-analysis on long-term renal outcomes among COVID-19 patients. We carried out a systematic literature search in PUBMED, EMBASE, SCOPUS, and Cochrane COVID-19 study register and performed the random-effects meta-analysis of rates. The search was last updated on November 23, 2022.…

Rank104.4

Systematic review or meta-analysis

Urban green spaces: lessons from COVID-19 for future public health crises.

Environmental research · 2026 · PMID 42679879

The COVID-19 pandemic constituted a global socioeconomic crisis with long-lasting consequences. In response to the rapid spread of the virus, governments implemented containment measures such as social distancing, mask mandates, and mobility restrictions, which also affected access to urban green spaces (UGS). This systematic review aimed to identify key lessons from the pandemic regarding the role of UGS during public health crises. The analysis included 155 studies published between 2020 and 2025, grouped into fo…

Rank104.2

Systematic review or meta-analysis

Factors Influencing the Uptake of Digital Health Interventions for Cardiovascular Disease Prevention Among Healthcare Providers: A Systematic Review.

Global heart · 2026 · PMID 42253600

BACKGROUND: Digital health interventions (DHIs) offer major potential for improving cardiovascular disease (CVD) primary and secondary prevention, but their adoption by healthcare providers (HCPs) remains inconsistent. OBJECTIVE: To identify barriers and facilitators to DHI uptake in CVD primary and secondary prevention from HCPs' perspectives. METHODS: We conducted a systematic review of studies published between 2020 and 2024 that investigated HCPs' perceptions of DHI implementation for CVD primary and secondary …

Rank104.1

Systematic review or meta-analysis

Clinical efficacy and adverse events of baricitinib treatment for coronavirus disease-2019 (COVID-19): A systematic review and meta-analysis.

Journal of medical virology · 2022 · PMID 34846766

New Research Last 24 Months356 records

Rank108.1

Systematic review or meta-analysis

Infectious Complications in Adults Receiving Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis of Nosocomial and Bloodstream Infection, Prevalence, Risk Factors, and Clinical Outcomes.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42930572

Rank102.7

Systematic review or meta-analysisResult signal: null

Effects of Telerehabilitation on Quality of Life, Physical Capacity, and Symptom Burden Within the Post-COVID-19 Condition: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR rehabilitation and assistive technologies · 2026 · PMID 42944723

BACKGROUND: Post-COVID-19 condition (PCC) is characterized by persistent symptoms and functional limitations that impair quality of life, and rehabilitation is an important component of its management. Because access to conventional face-to-face rehabilitation may be limited, telerehabilitation has emerged as an accessible alternative. However, the effectiveness of telerehabilitation across clinical outcomes remains uncertain, and the influence of different delivery modes is not well understood. OBJECTIVE: This stu…

Rank101.3

Randomized controlled trial

Clinica chimica acta; international journal of clinical chemistry · 2027 · PMID 42580608

Rank99.2

Randomized controlled trial

Safety and immunogenicity of Thailand Government Pharmaceutical Organization (GPO) produced, COVID-19 vaccine, 10 μg HXP-GPOVac: A Phase III, double-blind, randomized trial in comparison with VAXZEVRIA.

Vaccine · 2026 · PMID 42869875

BACKGROUND: HXP-GPOVac is a Thailand-produced, egg-based, inactivated recombinant Newcastle disease virus (NDV)-chimera vaccine expressing a membrane-anchored, prefusion-stabilized SARS-CoV-2 spike (NDV-HXP-S), developed to expand vaccine access. This phase III trial evaluated the safety and immunogenicity of a single HXP-GPOVac dose in healthy or clinically stable Thai adults who had completed a two-dose primary series of an authorized COVID-19 vaccine. METHODS: In this double-blind, randomized, active-controlled …

Rank98.0

Systematic review or meta-analysis

Reliability of accelerated confirmatory trials during the COVID-19 pandemic: the consequences of low pretrial plausibility.

Journal of clinical epidemiology · 2026 · PMID 42600710

OBJECTIVES: The reliability of confirmatory clinical trials (ie, the post-trial probability) depends on the pretrial probability. During the COVID-19 pandemic, many early COVID-19 confirmatory trials were launched despite limited phase II evidence and weak mechanistic or preclinical support. Whether this accelerated development strategy reduced the reliability of therapeutic evidence remains uncertain. STUDY DESIGN AND SETTING: Overall empirical pretrial plausibility was estimated at the trial level as the proporti…

Rank97.8

Randomized controlled trial

Journal of clinical epidemiology · 2026 · PMID 42551807

Rank96.0

Systematic review or meta-analysis

Telemedicine in Rheumatology in the United States: A Scoping Review of Modalities, Outcomes, and Costs in Support of a Hybrid Model of Care.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2026 · PMID 42932782

BACKGROUND: Shortages and geographic maldistribution of rheumatologists limit access to rheumatology care in the United States. Tele-rheumatology grew from targeted rural and Veterans Affairs programs into mainstream practice during the coronavirus disease 2019 pandemic, and its postpandemic role remains unsettled. OBJECTIVE: To map the modalities, settings, and reported outcomes of telemedicine in US rheumatology. DESIGN: Scoping review following Joanna Briggs Institute methodology and Preferred Reporting Items fo…

Rank95.5

Randomized controlled trialResult signal: harm

Challenges of Conducting a Feasibility Pilot Randomized Controlled Trial During COVID-19 Restrictions: Rivaroxaban Versus Acetyl Salicylic Acid in Patients with Multiple Myeloma on Lenalidomide-Based Therapy (RithMM).

Current oncology (Toronto, Ont.) · 2026 · PMID 42930200

Venous thromboembolism is a serious medical complication with an increased risk in patients with multiple myeloma undergoing combination treatment regimens. Acetylsalicylic acid is routinely used as a method of thromboprophylaxis in multiple myeloma patients treated with lenalidomide, and rivaroxaban has been assessed in small-scale studies in multiple myeloma patients treated with immunomodulatory drugs; yet, no study has compared the two methods. In this pilot, we asked if a full-scale trial would be feasible to …

Rank92.0

Randomized controlled trial

Influence of COVID-19 and COVID-19 rumours on trust and uptake of single-dose male HPV vaccination in the Add-Vacc cluster-randomised trial, northwest Tanzania.

Vaccine · 2026 · PMID 42854550

BACKGROUND: The COVID-19 pandemic impacted public health services and vaccination uptake globally. Trust in health services and vaccination programmes is critical for vaccine acceptance. Between 2020 and 2022, Tanzania shifted its acknowledgement of COVID-19 and its prevention strategies. National COVID-19 vaccination coverage reached 51% by April 2023. The Add-Vacc cluster-randomised trial (CRT) provided single-dose, human papillomavirus (HPV) vaccination to 14-18-year-old males in 2023-2024, the first time HPV va…

Rank91.6

Randomized clinical studyResult signal: null

Comparative Short-Term Clinical Events Associated with Molnupiravir and Ensitrelvir for COVID-19: A Retrospective Cohort Study Using Community Pharmacy Records in Japan.

Pharmacy (Basel, Switzerland) · 2026 · PMID 42931125

Molnupiravir and ensitrelvir are widely used for outpatient coronavirus disease 2019 treatment; however, real-world safety comparisons remain limited. This retrospective cohort study evaluated acute clinical event risks over a 29-day follow-up using community pharmacy records from Japanese patients newly prescribed either drug between January and September 2023. Hazard ratios (HRs) were estimated using multivariable Cox proportional hazard models. The analysis included 2051 patients prescribed molnupiravir and 563 …

Rank90.8

Randomized clinical study

Randomized controlled trial of pirfenidone XR for patients with COVID-19 and exploration of effects on long-COVID incidence.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42896728

OBJECTIVE: Evaluate safety and efficacy of extended-release pirfenidone (pirfenidone-XR), an anti-inflammatory and antifibrotic agent, as an early treatment for acute and long-term effects of COVID-19. METHODS: This double-blinded, placebo-controlled trial randomized hospitalized and ambulatory COVID-19 patients in Mexico City 2:1 to pirfenidone-XR or placebo. The primary endpoint was recovery dynamics using a clinical severity 7-point ordinal scale; secondary and exploratory endpoints included long COVID incidence…

Rank90.2

Randomized clinical studyResult signal: null

Which spontaneous breathing trial should be used to reproduce post-extubation respiratory effort in COVID-19-related ARDS? A multicenter randomized crossover study.

Anaesthesia, critical care & pain medicine · 2026 · PMID 42946130

BACKGROUND: Spontaneous breathing trials (SBT) guide extubation decisions in intensive care unit (ICU), predicting the respiratory effort required by the patient after extubation. Different SBTs exist and should be adapted to critical illness. Viral pneumonias such as COVID-19 combine lung injury, sepsis-induced systemic inflammation, and encephalopathy, making classification challenging. The objective was to assess which SBT could be used to reproduce postextubation respiratory effort in COVID-19-related acute res…

Rank89.5

Randomized clinical study

Physical Performance Outcomes and Programme Delivery Costs of ELDERPLAY, a Community-Based Multicomponent Exercise and Recreational Intervention for Older Adults: A Non-Randomized Controlled Evaluation.

Healthcare (Basel, Switzerland) · 2026 · PMID 42940486

Background/Objectives: This study examined the association between participation in a community-based multicomponent physical and recreational programme (ELDERPLAY) and changes in physical performance and frailty-related outcomes in adults aged 65 years and older, and estimated programme delivery costs. The study was designed as a quasi-experimental, non-randomized controlled evaluation conducted in a community setting. Methods: Community-dwelling older adults (n = 184) were allocated to an intervention group (n = …

Preclinical Research95 records

Rank98.0

Systematic review or meta-analysis

Pathogens (Basel, Switzerland) · 2026 · PMID 42931159

Favipiravir, an antiviral that inhibits viral RNA-dependent RNA polymerase, has demonstrated promise as a therapeutic for RNA viral infections such as SARS-CoV-2. Mathematical modeling of viral kinetics provides a tool for analyzing the progression of viral infections and the action of antiviral drugs. In the present investigation, the viral kinetics of SARS-CoV-2 infection in cynomolgus macaques treated with the antiviral drug favipiravir were analyzed using a target-cell-limited mathematical model of viral infect…

Promising Experimental Therapies71 records

Rank100.3

Systematic review or meta-analysis

Piperine: From Green Extraction to Clinical Translation-A Review.

Drug design, development and therapy · 2026 · PMID 42800936

BACKGROUND: Piperine has diverse pharmacological and bioenhancing activities, but poor aqueous solubility, variable exposure, interaction liability, and discontinuity across production, formulation, and clinical evaluation limit translation. This review integrates these frequently separated stages. METHODS: A structured narrative PubMed search covered English-language studies published from 1 January 2021 to 27 April 2026, supplemented by ClinicalTrials.gov records checked through 13 June 2026, backward citation se…

Rank97.6

Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.5

Randomized controlled trial

The Journal of infection · 2026 · PMID 42735873

BACKGROUND: GEO-CM04S1 is a synthetic modified vaccinia Ankara (sMVA)-based SARS-CoV-2 vaccine expressing Spike (S) and Nucleocapsid (N) antigens derived from the ancestral Wuhan-Hu-1 reference strain. This phase 2 study evaluated the safety and immunogenicity of two GEO-CM04S1 dose levels administered as a single booster in healthy adults previously vaccinated against COVID-19. METHODS: In this randomized, double-blind, parallel-group trial, participants received a single intramuscular booster of GEO-CM04S1 at eit…

Rank92.0

Randomized controlled trial

Serum Virus-Neutralizing Antibody Titers in Clinical Trial Participants With and Without Immunocompromise Receiving Pemivibart, a Long-Acting Monoclonal Antibody for COVID-19.

The Journal of infectious diseases · 2026 · PMID 42165235

Rank92.0

Randomized controlled trial

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42268674

This Phase 1 clinical trial evaluated the safety and immunogenicity of COVAC-2, a recombinant protein subunit vaccine as a heterologous booster in adults previously immunized with authorized COVID-19 vaccines (NCT05226702). COVAC-2 contains the SARS-CoV-2 S1 spike protein subunit adjuvanted with Sepivac SWE™, an open-access oil-in-water adjuvant. Sixty participants were randomized to receive a single intramuscular dose of COVAC-2 (10 µg or 25 µg) or placebo, with follow-up through Day 180. The vaccine was well tole…

Rank92.0

Randomized controlled trialResult signal: null

Phase IIB, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID-19.

European journal of haematology · 2026 · PMID 42117493

INTRODUCTION: Endothelial dysfunction is key in COVID-19 pathogenesis. This randomized, double-blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS-CoV-2 infection and respiratory failure. METHODS: One-hundred and fifty patients were randomized (2:1) to defibrotide or placebo, stratified by disease severity (WHO COVID-19 severity scale 4/5 vs. 6). The primary endpoint was clinical improvement time (days from first improvement through Day 30). RESULTS: …

Rank91.7

Randomized clinical study

Moving beyond the average: a method to measure health related-inequalities within randomised trials.

International journal for equity in health · 2026 · PMID 42811325

BACKGROUND: Randomised trials seldom investigate the impacts interventions have on socioeconomic inequality in health, focusing instead on their average treatment effects. METHODS: We illustrate how standard measures of inequality such as the corrected concentration index can be reported in randomised experiments to quantify the interventions' socio-economic distribution effect alongside more traditional average treatment effects. We illustrate this with a proof-of-concept example using a study on the impact of inf…

Rank89.0

Randomized controlled trial

Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19.

Frontiers in immunology · 2022 · PMID 35720389

UNLABELLED: COVID-19 emergency use authorizations and approvals for vaccines were achieved in record time. However, there remains a need to develop additional safe, effective, easy-to-produce, and inexpensive prevention to reduce the risk of acquiring SARS-CoV-2 infection. This need is due to difficulties in vaccine manufacturing and distribution, vaccine hesitancy, and, critically, the increased prevalence of SARS-CoV-2 variants with greater contagiousness or reduced sensitivity to immunity. Antibodies from eggs o…

Rank85.0

Randomized clinical study

Evaluation of the tuberculosis notification impact from an intermediary-facilitated public-private mix intervention in Viet Nam: A population-level quasi-experimental study.

PLoS medicine · 2026 · PMID 42776977

BACKGROUND: Treatment coverage gaps remain a major barrier to ending tuberculosis (TB). Public-private mix (PPM) entails the engagement of healthcare providers outside of national TB programs (NTP). PPM strategies are promoted to improve TB notification, particularly in high-burden settings with fragmented care systems, and intermediary agencies are recognized as effective mechanisms to operationalize PPM by bridging NTPs and out-of-network healthcare providers. However, population-level evidence is rare, as most e…

Rank69.2

Phase I clinical trial

Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42878689

The rapid development of effective COVID-19 vaccines was enabled by the parallel assessment of multiple candidates early in the pandemic, including candidates based on the Modified Vaccinia virus Ankara (MVA) vector platform. This Phase 1 trial (NCT04569383) evaluated the MVA-based vaccine candidate MVA-SARS-2-S, expressing the full-length native SARS-CoV-2 spike glycoprotein (Wuhan-HU-1). Between October 2020 and May 2021, 30 healthy, SARS-CoV-2-naive adults received two doses of either 107 or 108 international un…

Rank64.8

Observational or cohort study

Bidirectional Associations Between Autonomic Function, Sleep Quality, and Daily Fatigue and Energy Symptoms in Long COVID: Longitudinal Digital Health Study.

JMIR cardio · 2026 · PMID 42735381

BACKGROUND: Long COVID is characterized by persistent fatigue, with disrupted autonomic function and sleep disturbances frequently reported. Whether daily symptom severity influences subsequent sleep and autonomic recovery (the reverse temporal direction) remains underexplored. OBJECTIVE: This study aimed to examine bidirectional, within-person associations between objectively measured sleep quality, nocturnal heart rate variability (HRV), and daily fatigue and energy levels in individuals reporting post-COVID fati…

Rank55.0

Other PubMed-indexed publication

COVID-19 vaccination around immune checkpoint inhibitor start and survival in a nationwide cohort of patients with cancer.

Nature medicine · 2026 · PMID 42722885

Experimental data suggest that COVID-19 vaccination could modulate immune checkpoint inhibitor (ICI) effects, but population evidence is limited. Using the French health data system (Système National des Données de Santé), we identified 95,015 adults initiating ICI therapy between December 2020 and March 2023. We assessed mRNA vaccination within 100 days before ICI initiation using inverse probability of treatment weighting and within 100 days after ICI initiation among previously unvaccinated patients using a clon…

Rank50.8

Other PubMed-indexed publication

The unintended consequences of state policies on entrepreneurial activity and quality of work life: A social impact study.

The Journal of applied psychology · 2026 · PMID 41627323

The United States and other countries enacted various policies aimed at containing the spread of COVID-19. Though the pandemic itself took a physical, psychological, and economic toll on society, it is unclear how specific containment policies influenced longer term aspects of employment. Taking up this challenge, this research uses human agency theory to study the effects of U.S. state policy COVID-19 strictness, defined along the spectrum from the absence to the presence (e.g., none, recommended, and mandated) of…

Rank50.6

Other PubMed-indexed publication

Inflexible responses to uncertainty: The mediating role of psychological inflexibility in the link between intolerance of uncertainty, traumatic stress, and somatic symptoms.

Psychological trauma : theory, research, practice and policy · 2026 · PMID 40029269

OBJECTIVE: Intolerance of uncertainty (IU) and psychological inflexibility (PI) were shown to be risk factors of traumatic stress (TS) and somatic symptoms (SS) during COVID-19. The present study tested a structural equation model where PI mediated the relationships between IU, TS, and SS based on their theoretical and experimental overlaps. The contribution of all six PI facets including experiential avoidance (EA) and cognitive fusion (CF) were investigated. METHOD: The sample was made up of 656 participants who …

Rank48.8

Other PubMed-indexed publication

Mechanistically Guided Combinatorial Coding Based on Strand Displacement Probes for Multiplex Pathogen Variant Discrimination.

Angewandte Chemie (International ed. in English) · 2026 · PMID 42530284

Accurate and scalable discrimination of closely related genetic variants at single-nucleotide resolution remains challenge in molecular diagnostics, particularly under multiplexed conditions. Herein, we present a mechanistically guided Color-Coding Strategy for Multiple Variants Based on Single-Mutation-Responsive Strand-Displacement Padlock Probes that enables combinatorial color-coded identification of genetic variants with minimal parallel reactions. By integrating multiple isothermal amplification reactions (n)…

Prospective Cohort Studies176 records

Rank103.1

Systematic review or meta-analysis

Intravenous immunoglobulin for treatment of hospitalized COVID-19 patients: an evidence mapping and meta-analysis.

Inflammopharmacology · 2024 · PMID 38097885

BACKGROUND: The clinical efficacy and safety of intravenous immunoglobulin (IVIg) treatment for COVID-19 remain controversial. This study aimed to map the current status and gaps of available evidence, and conduct a meta-analysis to further investigate the benefit of IVIg in COVID-19 patients. METHODS: Electronic databases were searched for systematic reviews/meta-analyses (SR/MAs), primary studies with control groups, reporting on the use of IVIg in patients with COVID-19. A random-effects meta-analysis with subgr…

Rank100.0

Systematic review or meta-analysis

Social Isolation, Loneliness, and Cardiovascular Mortality: The Role of Health Care System Interventions.

Current cardiology reports · 2024 · PMID 38713361

PURPOSE OF REVIEW: The world is proliferating rapidly, with science and technology advancing at an incredible rate. These advances have, however, ushered in an age with a rise in social isolation (SI) and loneliness. SI is an objective term that refers to lacking social contact or support. On the other hand, loneliness is subjective and refers to feeling alone or isolated. These concepts are rapidly gaining prominence mainly due to their negative impact on the physical and psychological health of the population, ma…

Rank97.0

Randomized controlled trial

Impact of supermarket fruit and vegetable placement on store sales, customer purchasing, diet and household waste: A prospective matched-controlled cluster trial.

PLoS medicine · 2026 · PMID 41915648

BACKGROUND: Previous product placement trials have been underpowered and limited in outcomes. This study assessed effects of positioning an expanded fruit and vegetable section near entrances on store-level sales, household-level purchasing and waste, and dietary behaviours. METHODS AND FINDINGS: This prospective matched controlled cluster trial (NIHR 17/44/46) involved 36 stores (18 intervention and 18 control) of a discount supermarket chain in England. The study took place between March 2018 and May 2022, and th…

Rank95.2

Randomized controlled trialResult signal: null

An adaptive simulation intervention decreases emergency physician physiologic stress while caring for patients during COVID-19: A randomized clinical trial.

PloS one · 2025 · PMID 40901855

BACKGROUND: Stressful work environments and burnout in emergency medicine (EM) physicians adversely impact patient care quality. The future EM workforce will need to prioritize clinician well-being to ensure optimal patient care. METHODS: This prospective, randomized, controlled study aimed to determine whether an adaptive simulation intervention, COVID-19 Responsive Intervention: Systems Improvement Simulations (CRI:SIS), decreased physiologic stress as measured by heart rate variability (HRV) in front-line EM phy…

Rank95.0

Randomized controlled trialResult signal: harm

REmotely monitored, Mobile health-supported Multidomain Rehabilitation Program incorporating High-intensity Interval Training for COVID-19 (REMM-HIIT-CoV): trial design and rationale.

Physical therapy · 2026 · PMID 42752600

IMPORTANCE: Individuals hospitalized with COVID-19 are at increased risk for prolonged physical, cognitive, and psychosocial impairments. Timely post-acute rehabilitation may reduce these sequelae and accelerate recovery. OBJECTIVE: The objective is to determine whether a REmotely monitored, Mobile health-supported Multidomain Rehabilitation Program incorporating High-intensity Interval Training (REMM-HIIT-CoV) after COVID-19 hospitalization improves functional exercise capacity. DESIGN: This study is a multicenter…

Rank94.6

Randomized controlled trial

Muscle mass gain and strength recovery after discharge of critical COVID-19 patients treated with mesenchymal stromal cell infusion: a randomized clinical trial.

T cell correlates of COVID-19 risk are poorly defined, particularly in people with HIV (PWH). CoVPN 3008 ( NCT05168813 ) Part A was a prospective 14,002-participant cohort study that administered one or two doses of mRNA-1273 COVID-19 vaccine, depending on baseline SARS-CoV-2 serostatus, in participants (83% PWH) in sub-Saharan Africa. Participants self-monitored for prespecified COVID-19 symptoms, defined by Centers for Disease Control and Prevention symptom criteria. Previous work showed that protection from COVI…

Rank75.6

Multicenter clinical studyResult signal: harm

A COVID-19 specific multiparametric and ECG-based score for the prediction of in-hospital mortality: ELCOVID score.

Internal and emergency medicine · 2024 · PMID 38652232

We aimed to develop and validate a COVID-19 specific scoring system, also including some ECG features, to predict all-cause in-hospital mortality at admission. Patients were retrieved from the ELCOVID study (ClinicalTrials.gov identifier: NCT04367129), a prospective, multicenter Italian study enrolling COVID-19 patients between May to September 2020. For the model validation, we randomly selected two-thirds of participants to create a derivation dataset and we used the remaining one-third of participants as the val…

Quality Of Life74 records

Rank102.7

Systematic review or meta-analysisResult signal: null

Effects of Telerehabilitation on Quality of Life, Physical Capacity, and Symptom Burden Within the Post-COVID-19 Condition: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR rehabilitation and assistive technologies · 2026 · PMID 42944723

Rank97.8

Randomized controlled trial

Patients with MASH experience worse health-related quality of life: a multinational real-world study using LiverMultiScan.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026 · PMID 42911297

Rank96.0

Systematic review or meta-analysis

Waiting for elective orthopaedic surgery: a qualitative scoping review of the patient experience.

International journal for quality in health care : journal of the International Society for Quality in Health Care · 2026 · PMID 42858156

BACKGROUND: Public health waiting lists for elective or planned orthopaedic surgery are increasing to the point where demand far exceeds our ability to treat. This is largely due to ageing populations, rising obesity and the continued impact of delays caused by the COVID-19 pandemic. While waiting, patients suffer debilitating physical pain, functional limitation, social isolation, and associated mental health impacts while some are unable to work. This qualitative scoping review explored and mapped the experiences…

Rank95.8

Randomized controlled trial

The α2-Subunit Preferring GABA Positive Allosteric Modulator, N-Desmethyl-Clobazam in Peripheral Neuropathic Pain Patients: Results of a Phase IIa Randomised Placebo-Controlled Ascending Dose Study.

European journal of pain (London, England) · 2026 · PMID 42886059

Rank95.0

Randomized controlled trialResult signal: harm

REmotely monitored, Mobile health-supported Multidomain Rehabilitation Program incorporating High-intensity Interval Training for COVID-19 (REMM-HIIT-CoV): trial design and rationale.

Physical therapy · 2026 · PMID 42752600

Rank92.0

Randomized controlled trial

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026 · PMID 42850372

Rank85.0

Randomized clinical studyResult signal: null

Interventions to Reduce Burnout for Military Physicians: A Scoping Review.

Military medicine · 2026 · PMID 42837269

INTRODUCTION: Physician burnout is an increasingly researched topic, particularly since the COVID-19 pandemic. Burnout reduction interventions, both organizational and individual, have been studied in the civilian healthcare setting. Few have been conducted in military settings. A 2022 United States (U.S.) Department of Defense (DOD) Inspector General report identified staff burnout and fatigue as a serious concern for Military Treatment Facilities. Other studies identified a significant association between burnout…

Rank78.8

Multicenter clinical study

Unemployed Burn Survivors Experience Significantly Worse Long-Term Psychosocial and Functional Outcomes: A Burn Model System Study.

Plastic and reconstructive surgery · 2026 · PMID 41481395

BACKGROUND: The impact of preinjury employment status on patient-reported outcomes after injury is not well described. This study compared psychosocial and functional domains between adults who were employed or unemployed before sustaining a burn injury to examine the association of employment status with long-term outcomes. METHODS: Adult participants enrolled in the Burn Model System national, multicenter database between 2013 and 2023 were included. Associations between preburn employment status and long-term ou…

Rank73.0

Multicenter clinical study

Assessing the performance of Hungary's primary health care system during the COVID-19 pandemic: findings from the cross-sectional PRICOV-19 study.

BMC primary care · 2026 · PMID 42420846

BACKGROUND: Primary care (PC) has played a crucial role in the fight against the COVID-19 epidemic. The novel challenges have significantly increased the workload for PC workers, leading to negative impacts on their mental health. Hungarian primary care is in the early stage of moving from solo practices to primary health care teams, while the number of elderly physicians increases quickly. The PRICOV-19 study is a multicenter study in 38 countries that comprehensively assesses the performance of PC during the pand…

Rank70.0

Multicenter clinical study

Workplace and personal predictors of well-being in the broader maternity and neonatal workforce during COVID-19: evidence from a multicentre survey.

BMC health services research · 2026 · PMID 42928238

BACKGROUND: The COVID-19 pandemic placed unprecedented pressures on maternity and neonatal services, disrupting models of care and amplifying existing stressors for healthcare staff. While much of the literature has focused on doctors and midwives, less is known about the emotional well-being of the broader multidisciplinary maternity and neonatal workforce, including neonatal nurses, sonographers, allied health, and administrative staff. Understanding the collective impact of workplace and personal factors on emot…

Rank65.0

Prospective cohort study

Correlates of fatigue in SARS-CoV-2-positive and -negative adolescents and young adults: Repeated cross-sectional analyses from a prospective cohort study.

Journal of psychosomatic research · 2026 · PMID 42235362

PURPOSE: To investigate cross-sectional associations between concurrent fatigue and a range of covariates in adolescents and young adults with acute SARS-CoV-2 infection and follow-up six months after infection, as well as in SARS-CoV-2-negative controls. METHODS: A total of 404 SARS-CoV-2 -positive adolescents and young adults were studied during their infection and again six months post-infection, compared to 105 SARS-CoV-2-negative controls. In this exploratory study, cross-sectional linear regression analyses w…

Rank54.3

Other PubMed-indexed publication

Prevalence and Trends of Post-COVID-19 Sequelae Among U.S. Adults With Prior COVID-19 Infection, 2022-2024.

Cureus · 2026 · PMID 42921630

BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection (PASC) affect a substantial proportion of U.S. adults, involving multiple organ systems and resulting in significant disability and diminished quality of life. Population-level PASC estimates include individuals without prior COVID-19 infection and therefore do not accurately reflect postinfection risk required for effective risk stratification. We estimated the prevalence and trends of PASC among U.S. adults with prior COVID-19. METHODS: We analyzed data from…

Rank53.9

Other PubMed-indexed publication

Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.

Human vaccines & immunotherapeutics · 2026 · PMID 42610257

The aim of the present study was to prospectively investigate the associations between psychological wellbeing and COVID-19 outcomes (vaccination, infection, long COVID) based on the Survey of Health, Aging, and Retirement in Europe (SHARE), using the data from Wave 8 and two supplementary COVID-19 surveys (Corona Survey 1 and 2) covering 27 European countries and Israel. Furthermore, we also conducted a cross-sectional study to evaluated the joint effects of wellbeing and vaccination status on the risks of SARS-Co…

Rank53.8

Other PubMed-indexed publication

Temporomandibular Disorder-Related Symptoms and Health-Related Quality of Life among Japanese Adults.

JDR clinical and translational research · 2026 · PMID 42935443

Rank53.4

Other PubMed-indexed publication

The Burden of Alcohol-Related Caring for Others in Australia in the 2021 Pandemic Period.

Journal of studies on alcohol and drugs · 2024 · PMID 38445854

OBJECTIVE: The magnitude of caring for others because of excessive alcohol use is unclear in Australia and internationally. This study explores the prevalence, sociodemographic predictors, and consequences of informal care for others because of alcohol use. METHOD: A survey on harm from others' drinking was conducted among 2,574 Australian adults in November 2021 from national random digit dial and "Life in Australia" panel samples to elicit representative data. Respondents who indicated that they had "heavy drinke…

Rank53.0

Other PubMed-indexed publication

Impact of veterans' military-to-civilian transition experiences on their longer-term mental health.

Social psychiatry and psychiatric epidemiology · 2026 · PMID 41559196

PURPOSE: How well the over 200,000 U.S. servicemembers who complete military service each year navigate the transition to civilian life may impact their later-life outcomes, with smoother transitions increasing resilience to later life stressors and leading to better long-term outcomes. The purpose of this study was to examine whether veterans who experience better military-to-civilian transitions are less vulnerable to poor mental health when faced with later stressors. METHODS: Data were drawn from a population-b…

Rank52.3

Other PubMed-indexed publication

Long COVID and Incident Multimorbidity in the United States: Evidence from a Nationally Representative Longitudinal Study.

Healthcare (Basel, Switzerland) · 2026 · PMID 42940472

Background/Objectives: Long COVID has been associated with elevated risks of individual chronic conditions, but its association with the transition to multimorbidity remains unclear. This study aims to examine whether retrospective COVID-19 status was associated with incident multimorbidity among U.S. adults. Methods: We analyzed Panel 24 of the Medical Expenditure Panel Survey (MEPS; 2019-2022), including 4356 individuals free of multimorbidity at baseline. COVID-19 exposure was classified as Long COVID, COVID-19-…

Rank52.0

Other PubMed-indexed publication

Factors associated with severe neurological sequelae of COVID-19: findings from the multicenter COVID-BRAIN imaging cohort.

Frontiers in human neuroscience · 2026 · PMID 41939224

INTRODUCTION: Neurological post-acute sequelae of COVID-19 (neuroPASC) are associated with persistent cognitive dysfunction and quality-of-life decline. We aimed to identify clinical, behavioral and sociodemographic factors associated with neuroPASC symptom burden two years after COVID-19 among individuals without prior neurological disease. METHODS: In this prospective, observational study, individuals with neuroPASC (n = 102) and controls without symptomatic COVID-19 (n = 74), all without prior neurological, psyc…

Rank51.9

Other PubMed-indexed publication

Patient-centered communication and emotional well-being among cancer survivors: The role of online peer interaction and the COVID-19 context.

Patient education and counseling · 2026 · PMID 42632321

OBJECTIVE: Patient-centered communication (PCC) predicts better emotional well-being among cancer survivors, but whether this benefit holds across changing care contexts is unclear. The COVID-19 pandemic, which disrupted in-person care and shifted survivors toward digital support, offers a natural test of whether PCC's value depends on context. We examined how the PCC-well-being association varies across pandemic periods and online participation, and whether self-efficacy consistently mediates it. METHODS: Data cam…

Randomized Controlled Trials157 records

Rank109.0

Systematic review or meta-analysis

Molnupiravir for treating COVID-19.

The Cochrane database of systematic reviews · 2025 · PMID 41147546

Rank108.5

Systematic review or meta-analysisResult signal: benefit

Traditional, complementary, and integrative medicine therapies for mild/moderate acute COVID-19: a systematic review and network meta-analysis.

Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026 · PMID 42735469

Rank107.5

Systematic review or meta-analysisResult signal: null

Sotrovimab in the treatment of coronavirus disease-2019 (COVID-19): a systematic review and meta-analysis of randomized clinical trials.

Naunyn-Schmiedeberg's archives of pharmacology · 2024 · PMID 39031183

Rank107.3

Systematic review or meta-analysis

Blood Biomarkers of Long COVID: A Systematic Review.

Molecular diagnosis & therapy · 2024 · PMID 39103645

Rank106.8

Systematic review or meta-analysis

The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology · 2024 · PMID 39225947

Rank106.8

Systematic review or meta-analysisResult signal: mixed

Extended Prone Positioning in ARDS: A Systematic Review and Meta-Analysis.

Respiratory care · 2026 · PMID 41631378

Rank106.6

Systematic review or meta-analysisResult signal: null

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.

Journal of rehabilitation medicine · 2026 · PMID 42895360

Rank106.1

Systematic review or meta-analysis

Anticoagulants for people hospitalised with COVID-19: a rapid review.

The Cochrane database of systematic reviews · 2022 · PMID 35244208

Rank106.0

Systematic review or meta-analysis

Mesenchymal Stem Cells on Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Stem cell reviews and reports · 2024 · PMID 38427315

Rank106.0

Systematic review or meta-analysisResult signal: harm

Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis.

BMJ global health · 2024 · PMID 38580375

Rank105.4

Systematic review or meta-analysisResult signal: null

Effect of subcutaneous vs. intravenous tocilizumab in patients with severe COVID-19: a systematic review.

European journal of clinical pharmacology · 2024 · PMID 38926166

Rank102.6

Systematic review or meta-analysis

Effect of modified intravascular laser irradiation of blood in the oral and systemic conditions during dental treatment-A systematic review.

Lasers in medical science · 2024 · PMID 39704836

The aim of this study was to investigate the scientific evidence regarding the effectiveness of modified-ILIB (intravascular laser irradiation of blood) in the control of systemic conditions and/or oral changes during dental care. This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control of systemic conditions and/or oral changes in children and adults during dental treatment?". The protocol for this systematic review was registered in the P…

Rank102.6

Systematic review or meta-analysis

The effect of probiotics on the risk of mortality in patients with COVID-19: systematic review and meta-analysis of randomized trials.

Inflammopharmacology · 2023 · PMID 37848697

Probiotics have been hypothesized to play a beneficial role in modulating immune responses and gut microbiota in various clinical settings. This systematic review and meta-analysis aimed to assess the effectiveness of probiotics in reducing all-cause mortality among patients diagnosed with COVID-19. We conducted a comprehensive search of the following databases: PubMed, Scopus, and Web of Science for published studies, and medRxiv, Research Square, and SSRN for preprints. The search spanned from the inception of th…

Rank101.3

Randomized controlled trial

BMC pulmonary medicine · 2026 · PMID 42920113

BACKGROUND: High-flow nasal cannula (HFNC) is widely used as an early respiratory support strategy for adults with acute hypoxemic respiratory failure (AHRF). Although HFNC may reduce the risk of endotracheal intubation, it remains uncertain whether the available evidence is sufficiently mature and whether this potential benefit translates into improved survival. We performed a systematic review and meta-analysis with trial sequential analysis (TSA) and GRADE assessment to assess HFNC versus standard oxygen therapy…

Rank100.0

Randomized controlled trial

Immune correlates analysis in NextCOVE trial for a next-generation mRNA-1283 COVID-19 vaccine.

Human vaccines & immunotherapeutics · 2026 · PMID 42220116

SARS-CoV-2 neutralizing antibodies (nAbs) are strongly inversely associated with COVID-19 risk and have correlated with vaccine efficacy across multiple clinical trials conducted during the COVID-19 pandemic. As SARS-CoV-2 continues to evolve in the endemic era, it is important to determine whether nAb levels remain a valid statistical correlate of protection and potential surrogate endpoints for emerging variants. The next-generation COVID-19 vaccine, mRNA-1283, has recently received regulatory approval worldwide.…

Safety And Adverse Effects147 records

Rank108.1

Systematic review or meta-analysis

Infectious Complications in Adults Receiving Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis of Nosocomial and Bloodstream Infection, Prevalence, Risk Factors, and Clinical Outcomes.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42930572

Rank104.1

Systematic review or meta-analysis

Clinical efficacy and adverse events of baricitinib treatment for coronavirus disease-2019 (COVID-19): A systematic review and meta-analysis.

Journal of medical virology · 2022 · PMID 34846766

Rank101.3

Randomized controlled trial

Evaluating a multi-vaccine respiratory immunization strategy involving SARS-CoV-2, pneumococcal, and influenza vaccines in adults: A randomized, open-label, multicenter, controlled, non-inferiority Phase IV trial in China.

Human vaccines & immunotherapeutics · 2026 · PMID 42904667

Rank100.7

Systematic review or meta-analysis

Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID-19 vaccine.

Journal of medical virology · 2022 · PMID 34862617

Rank100.0

Systematic review or meta-analysisResult signal: benefit

Efficacy and safety of current treatment interventions for patients with severe COVID-19 infection: A network meta-analysis of randomized controlled trials.

Journal of medical virology · 2022 · PMID 34882805

Rank100.0

Systematic review or meta-analysis

Journal of medical virology · 2022 · PMID 34837230

Rank100.0

Systematic review or meta-analysis

Exploring the experiences, views, and needs of family members of emergency response workers: a systematic review and meta-synthesis.

European journal of psychotraumatology · 2026 · PMID 42706908

Background: Emergency responders, including firefighters, police officers, and paramedics, face workplace challenges that may harm their well-being. They typically rely on family members for support, which may have damaging effects on the family system. While the experiences of emergency responders are well established, their families' subsequent struggles are less well explored.Objective: This review explores the experiences, views, and needs of family members, through determining the mental health and well-being …

Rank99.2

Randomized controlled trial

Safety and immunogenicity of Thailand Government Pharmaceutical Organization (GPO) produced, COVID-19 vaccine, 10 μg HXP-GPOVac: A Phase III, double-blind, randomized trial in comparison with VAXZEVRIA.

Vaccine · 2026 · PMID 42869875

Rank98.2

Randomized controlled trial

Dissociation between humoral and multi-omic immune responses to inactivated COVID-19 vaccination in patients with pulmonary tuberculosis.

Frontiers in immunology · 2026 · PMID 42827549

INTRODUCTION: Patients with pulmonary tuberculosis (PTB) may experience persistent immune dysregulation during anti-tuberculosis treatment, yet vaccine evaluation in this population has largely relied on humoral endpoints. Whether preserved antibody responses reflect coordinated systems-level immune activation after inactivated COVID-19 vaccination remains unclear. This study used systems vaccinology to identify multi-omic immune signatures induced by vaccination in PTB patients. METHODS: We compared PTB patients w…

Rank97.6

Randomized controlled trial

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2026 · PMID 42932782

Rank95.5

Randomized controlled trialResult signal: harm

Challenges of Conducting a Feasibility Pilot Randomized Controlled Trial During COVID-19 Restrictions: Rivaroxaban Versus Acetyl Salicylic Acid in Patients with Multiple Myeloma on Lenalidomide-Based Therapy (RithMM).

Current oncology (Toronto, Ont.) · 2026 · PMID 42930200

Rank95.2

Randomized controlled trial

Frontiers in immunology · 2026 · PMID 42827549

Rank98.0

Randomized controlled trial

Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts.

The New England journal of medicine · 2026 · PMID 42127390

BACKGROUND: Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 (Covid-19). Previously, no antiviral agents were approved for postexposure prophylaxis in household contacts of patients with Covid-19. METHODS: In this double-blind, randomized, placebo-controlled trial, we randomly assigned persons who were SARS-CoV-2-negative on local diagnostic testing but were household c…

Rank98.0

Randomized controlled trial

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42370465

BACKGROUND: Despite the relative success of immuno-modulatory disease-modifying therapy in relapsing remitting multiple sclerosis, progressive worsening of disability remains a major problem, particularly for those with secondary progressive multiple sclerosis. Various underlying mechanisms are likely to contribute, augmented by comorbidities (such as vascular risk) and ageing. In the phase 2b MS-STAT trial, simvastatin (80 mg) (Sandoz Ltd, Camberley, UK) reduced the mean annualised whole brain atrophy rate by 43% …

Rank97.9

Randomized controlled trial

Duration of external neck stabilisation in the management of older and frail patients with a new odontoid fracture: the DENS RCT.

Health technology assessment (Winchester, England) · 2026 · PMID 42104907

BACKGROUND: Fractures of the cervical spine's odontoid process can result from low-impact falls in frail or older adults, and are usually managed in hard collars to immobilise the fracture and promote bony healing. However, bony healing often does not occur in older/frail adults and is not necessary for good outcomes. Further, hard collars can cause complications, such as skin pressure ulcers, and difficulties with swallowing or personal care. OBJECTIVE: To examine whether management of odontoid process fractures w…

Rank97.8

Randomized controlled trialResult signal: harm

Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.

Social psychiatry and psychiatric epidemiology · 2026 · PMID 39251412

BACKGROUND: Social participation as a protective factor against cognitive decline was one of the targets in the AgeWell.de study, a multi-domain interventional trial in a sample of older adults at increased risk for dementia. This study aimed to examine differential effects of the intervention and other influencing factors on social participation throughout the trial. METHODS: A longitudinal analysis of study data at the primary follow-up after 24 months (n = 819) was conducted. The Lubben Social Network Scale (LSN…

Rank97.6

Randomized controlled trialResult signal: null

Evaluating the effectiveness of a telemedicine-based STEADI implementation in primary care on fall outcomes: the STEADI options randomized controlled trial.

The Gerontologist · 2026 · PMID 41349283

BACKGROUND AND OBJECTIVES: Falls are a leading cause of injury and death among older adults (65 years and above). The Centers for Disease Control and Prevention's Stopping Elderly Accident, Deaths, and Injuries (STEADI) initiative aims to reduce falls by screening to find at-risk individuals, evaluation, and then addressing modifiable risk factors. This study evaluated the effectiveness of implementing a STEADI-based multi-component fall prevention approach via telemedicine in primary care. RESEARCH DESIGN AND METH…

Rank97.5

Randomized controlled trialResult signal: null

Patient-Centered Prescription Opioid Tapering Methods: A Randomized Clinical Trial.

Annals of internal medicine · 2026 · PMID 42407075

BACKGROUND: Evidence is needed on tapering long-term prescription opioids in outpatient settings. OBJECTIVE: To determine and compare the effectiveness of 3 opioid tapering and pain control strategies (July 2018 to November 2023). DESIGN: Randomized controlled trial. (ClinicalTrials.gov: NCT03445988). SETTING: 11 U.S. sites. PARTICIPANTS: Adults with pain for at least 6 months receiving a morphine equivalent daily dose (MEDD) of 10 or higher for at least 3 months without moderate or severe opioid use disorder. INTE…

Rank97.2

Randomized controlled trialResult signal: null

Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42153520

BACKGROUND: HomeHealth is a home-based, voluntary sector service supporting older people with mild frailty to maintain independence through behaviour change. Support workers discuss the person's priorities and enable setting/achieving goals around mobility, nutrition, socialising and/or psychological well-being. AIMS: We tested clinical and cost-effectiveness of HomeHealth for maintaining independence in older people with mild frailty in a randomised controlled trial. METHODS: Design: Single-blind, parallel randomi…

Rank96.9

Randomized controlled trialResult signal: null

A randomized controlled trial testing a digital intervention to promote weight loss and weight loss maintenance.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026 · PMID 41989407

OBJECTIVE: This study aimed to determine the effectiveness and cost-effectiveness of the Choosing Health program, which tailors support to an individual's weight loss and weight loss maintenance determinants among adults with overweight and obesity. METHOD: We conducted a randomized controlled trial with a nested interrupted time series within-person design. Participants (N = 288) were randomized to the Choosing Health digital intervention (n = 145) or a control group (n = 143). Intervention participants completed …

Rank96.9

Randomized controlled trialResult signal: null

Dexmedetomidine for sedation during noninvasive ventilation in COVID-19 patients from the Helmet-COVID randomized clinical trial post-hoc analysis.

Scientific reports · 2026 · PMID 42103809

Dexmedetomidine may be used in patients managed by noninvasive ventilation (NIV), but its associations with intubation, mortality and health-related quality of life (HRQoL) are unclear. Thus, we aimed to assess the use of dexmedetomidine in patients with COVID-19-induced acute hypoxemic respiratory failure requiring NIV and its associations with the 28-day intubation rate, 28- and 180-day mortality rate, and HRQoL. This post-hoc study of the Helmet-COVID trial analyzed data from NIV-managed patients who did and did…

Rank96.9

Randomized controlled trial

Evaluating a Tailored Web-Based eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic: Randomized Clinical Trial.

Journal of medical Internet research · 2026 · PMID 42430132

BACKGROUND: Prostate cancer (PCa) is the most common nonskin cancer among men. Although treatments achieve excellent survival for localized PCa, long-lasting complications significantly diminish patients' quality of life (QOL) across physical, sexual, psychosocial, and general symptom domains. Because these effects also profoundly impact intimate partners, often reducing partners' QOL as much as or more than patients' QOL, supportive care must address the needs of both members of the couple. OBJECTIVE: This study e…

Rank96.8

Randomized controlled trialResult signal: null

The WORKWELL programme: a randomized controlled trial of job retention vocational rehabilitation for people with inflammatory arthritis.

Rheumatology (Oxford, England) · 2026 · PMID 42467833

OBJECTIVE: People with inflammatory arthritis (InfA) frequently experience work instability, absenteeism, and reduced productivity, culminating in early job loss. This study evaluated the effectiveness and cost-effectiveness of WORKWELL job retention vocational rehabilitation (JRVR) delivered by occupational therapists, compared with a control group receiving written self-help advice. METHODS: A pragmatic, multicentre randomized controlled trial was conducted across 18 UK National Health Service (NHS) Trusts. Emplo…

Rank96.8

Randomized controlled trial

Microfracture with or without collagen scaffold insertion for adults with chondral or osteochondral defects of the knee: the SISMIC RCT and its challenges during and after the COVID-19 pandemic.

Health technology assessment (Winchester, England) · 2026 · PMID 41178217

BACKGROUND: Around 10,000 symptomatic knee articular cartilage injuries requiring repair occur annually in the United Kingdom, mostly in people under 35 years of age. Microfracture surgery aims to restore cartilage. Adding microstructural scaffolds made of collagen may further improve outcomes. OBJECTIVES: To evaluate the clinical and cost-effectiveness of microstructural scaffold in patients undergoing microfracture for a symptomatic chondral or osteochondral defect of the knee. DESIGN: Multicentre, parallel two-g…

Rank96.7

Randomized controlled trialResult signal: null

A Pilot Placebo-Controlled Randomized Trial of Repeated High-Dose Intravenous Magnesium Sulphate and High-Dose Nebulized Budesonide for Severe Asthma in the Paediatric Emergency Department.

Journal of paediatrics and child health · 2026 · PMID 42605209

OBJECTIVE: Determine if high-dose intravenous magnesium with/without nebulized budesonide for children with acute severe asthma is safe and reduces time to medical readiness for discharge compared to standard intravenous magnesium. METHODS: Either 2 doses of intravenous magnesium or 1 dose and placebo, each with/without high-dose nebulized budesonide, were given in a double-blind randomized trial to study patients in addition to standard-of-care asthma treatment. Time to medical readiness for discharge was the prim…

Rank96.6

Randomized controlled trialResult signal: null

A randomized controlled trial of adjunctive speleotherapy in asthma, COPD and long COVID.

Scientific reports · 2026 · PMID 42173973

Speleotherapy (underground climate therapy) is a non-pharmacological intervention for chronic respiratory diseases. This randomized controlled trial investigated whether a 3-week speleotherapy course (6 sessions, 2 h/week) improves respiratory outcomes in patients on standard background therapy with asthma, COPD, or Long COVID, and whether it affects blood CO2 levels. The control group did not receive speleotherapy but continued their standard therapy. A total of 208 patients (asthma: n = 107; COPD: n = 59; Long CO…

Rank96.4

Randomized controlled trialResult signal: null

Can An Innovative Physical Therapy Program Enhance Mobility in Middle-Aged and Older Veterans With Slow Walking Speed? A Randomized Controlled Trial.

Archives of physical medicine and rehabilitation · 2026 · PMID 41397627

OBJECTIVE: To investigate the efficacy of an innovative physical therapy program targeting mobility. DESIGN: Single-blinded randomized controlled trial. SETTING: Outpatient care VA regional tertiary care center. PARTICIPANTS: Community-dwelling middle-aged and older Veterans (N=150) with slow walking speed. INTERVENTIONS: Live Long Walk Strong (LLWS) is an 8-week, 10 (1-h/session) session outpatient physical therapy program. It was designed to enhance mobility by targeting impairments linked to mobility decline. It…

Rank96.3

Randomized controlled trialResult signal: benefit

Virtual Reality-Assisted Therapy Compared to Cognitive Behavioral Therapy for Patients With Treatment-Resistant Schizophrenia: Assessor-Blind Randomized Controlled Trial.

JMIR mental health · 2026 · PMID 42748056

BACKGROUND: Auditory verbal hallucinations (AVH) are among the most disabling symptoms of schizophrenia and often persist despite treatment. Virtual reality-assisted therapies (VRTs) are a new generation of relational interventions for AVH, but comparative evidence against active interventions is currently lacking. OBJECTIVE: This study aimed to assess whether VRT (9 sessions) is superior to a short course of cognitive behavioral therapy (CBT) targeting AVH (9 sessions) in reducing AVH in individuals with treatment…

Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.