Alexandria Medical Evidence Library
Library/Viral infections/COVID-19

Viral infections evidence library

COVID-19

A living PubMed evidence library for SARS-CoV-2 prevention, acute COVID-19 treatment, severe disease, post-COVID conditions, and emerging variants.

PubMed only Research ranked Conflicts shown Data downloadable

Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 1,008 non-retracted PubMed-indexed records for COVID-19. The structured collection includes 5 guideline or consensus records, 124 evidence syntheses/systematic reviews/meta-analyses, and 126 randomized or phase III studies. 398 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 774 of 1,008 included records.

Engine 0.3.2 Snapshot v2 Updated 2026-08-02 Download source data · CSV
PubMed records1,008Non-retracted records included
Last 24 months398Records found by the recent-research search
High-priority evidence250Syntheses, reviews, randomized and phase III studies
Effect estimates293Machine-readable values extracted from abstracts
COI statements76.8%Coverage within PubMed records
Funding records215PMIDs with grant/funding metadata
Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years
5
2020
12
2021
27
2022
16
2023
28
2024
46
2025
873
2026
1
2027
Evidence composition

Study designs

Other or unclassified564
Randomized trials119
Meta-analyses80
Preclinical/laboratory64
Cohort studies48
Systematic reviews44
Prospective cohorts26
Observational studies23
Phase II trials8
Case reports8
Transparency

Conflict-of-interest reporting

Reported no conflicts389
COI statement present309
Not reported in PubMed record234
Declared financial/industry relationship76

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract919
Neutral/null signal44
Harm signal32
Supportive signal9
Mixed signal4
Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0
0.250.51.02.04.0
not_reported Odds Ratio · PMID 39251412 · 2026
1.38
not_reported Odds Ratio · PMID 39251412 · 2026
0.84
not_reported Risk Ratio · PMID 41261059 · 2026
0.80 95% CI 0.60–1.06
not_reported Risk Ratio · PMID 41261059 · 2026
0.94 95% CI 0.88–1.00
not_reported Risk Ratio · PMID 41261059 · 2026
0.70 95% CI 0.51–0.97
not_reported Risk Ratio · PMID 41424145 · 2026
0.85 95% CI 0.80–0.91
not_reported Risk Ratio · PMID 41424145 · 2026
0.87 95% CI 0.79–0.96
not_reported Risk Ratio · PMID 41424145 · 2026
0.93 95% CI 0.76–1.15
not_reported Risk Ratio · PMID 41424145 · 2026
1.35 95% CI 0.85–2.15
not_reported Risk Ratio · PMID 41424145 · 2026
0.79
not_reported Risk Ratio · PMID 41424145 · 2026
0.92 95% CI 0.81–1.04
not_reported Odds Ratio · PMID 41429349 · 2026
0.93
not_reported Odds Ratio · PMID 41429349 · 2026
2.04
not_reported Odds Ratio · PMID 41429349 · 2026
1.78
View extracted numerical results 60
PublicationOutcomeMeasureReported valueSource
Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.Social psychiatry and psychiatric epidemiology · 2026 not_reported Odds Ratio 1.38 PMID 39251412
Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.Social psychiatry and psychiatric epidemiology · 2026 not_reported Odds Ratio 0.84 PMID 39251412
Clinical Outcomes of a Real-Time e-Wound Care Map: A Prospective Study on an Intelligent Model to Improve Wound Care Quality in Hospitals.Plastic and reconstructive surgery · 2026 mortality Percentage Comparison 3.6percent vs 6.7percent P < 0.05 PMID 41172341
Repeated-dose behavioral intervention to reduce opioid overdose among overdose survivors with opioid use disorder: A two-site phase III randomized controlled trial.Addiction (Abingdon, England) · 2026 not_reported Risk Ratio 0.8 95% CI 0.6–1.06 P = 0.45 PMID 41261059
Repeated-dose behavioral intervention to reduce opioid overdose among overdose survivors with opioid use disorder: A two-site phase III randomized controlled trial.Addiction (Abingdon, England) · 2026 not_reported Risk Ratio 0.94 95% CI 0.88–1.0 P = 0.06 PMID 41261059
Repeated-dose behavioral intervention to reduce opioid overdose among overdose survivors with opioid use disorder: A two-site phase III randomized controlled trial.Addiction (Abingdon, England) · 2026 not_reported Risk Ratio 0.7 95% CI 0.51–0.97 P = 0.03 PMID 41261059
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.85 95% CI 0.8–0.91 p < 0.0001 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.87 95% CI 0.79–0.96 p = 0.002 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.93 95% CI 0.76–1.15 p = 0.14 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 1.35 95% CI 0.85–2.15 p = 0.14 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.79 p = 0.0004 PMID 41424145
The impact of the COVID-19 pandemic on osteoporotic fractures: a systematic review and meta-analysis.Annals of medicine · 2026 not_reported Risk Ratio 0.92 95% CI 0.81–1.04 p = 0.0004 PMID 41424145
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 0.93 PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 2.04 PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 1.78 PMID 41429349
Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 not_reported Odds Ratio 2.02 PMID 41429349
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026 not_reported Odds Ratio 5.45 95% CI 4.43–6.71 PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026 not_reported Odds Ratio 7.71 95% CI 5.97–9.96 PMID 41496460
Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.Scandinavian journal of primary health care · 2026 not_reported Odds Ratio 5.32 95% CI 4.84–5.85 PMID 41496460
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026 mortality Odds Ratio 4.66 PMID 41504189
Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.Pulmonology · 2026 mortality Odds Ratio 3.34 PMID 41504189
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 1.19 95% CI 0.7–2.01 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 5.48 95% CI 0.7–43.09 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.4 95% CI 0.17–0.97 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.43 95% CI 0.18–1.06 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.15 95% CI 0.04–0.54 PMID 41571287
Differences in COVID-19-related hospitalization burden between kidney transplant recipients and hemodialysis patients vaccinated against COVID-19.Human vaccines & immunotherapeutics · 2026 response Odds Ratio 0.12 95% CI 0.03–0.47 PMID 41571287
Longitudinal changes in health-related quality of life after a breast cancer diagnosis in sub-Saharan Africa: Evidence from the prospective ABC-DO cohort.International journal of cancer · 2026 not_reported Odds Ratio 1.32 95% CI 1.22–1.42 PMID 41609400
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026 not_reported Odds Ratio 100.0 PMID 41627968
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026 adverse events Odds Ratio 2.0 PMID 41627968
The role of age, sex, and ethnicity in vaccine trust, and sources of information in Canada: Findings from a national survey.Human vaccines & immunotherapeutics · 2026 not_reported Percentage Comparison 87.0percent vs 83.0percent PMID 41640305
Association between prior COVID-19 infection and acute mountain sickness on Jade Mountain: A prospective observational study (2023-2024).Journal of infection and public health · 2026 not_reported Odds Ratio 1.36 PMID 41643499
Association between prior COVID-19 infection and acute mountain sickness on Jade Mountain: A prospective observational study (2023-2024).Journal of infection and public health · 2026 not_reported Odds Ratio 1.34 PMID 41643499
A Cluster Randomized Trial of a Vaccination Communication Educational Intervention: Impact on COVID-19 Vaccine Uptake in Veterans.Journal of general internal medicine · 2026 not_reported Odds Ratio 1.16 p = 0.28 PMID 41680545
Performance of an indigenously developed high-flow nasal cannula device in healthy human volunteers.BMC anesthesiology · 2026 not_reported Odds Ratio 60.0 PMID 41699466
Neonatal intensive care unit admission among infants born full-term to CDC's COVID-19 Vaccine Pregnancy Registry participants: A matched cohort study.Human vaccines & immunotherapeutics · 2026 not_reported Percentage Comparison 7.7percent vs 11.3percent PMID 41774852
Acute respiratory infection (COVID-19) risk prediction in travelers: A random forest model.Infectious Disease Modelling · 2026 not_reported Percentage Comparison 0.7percent vs 1.4percent PMID 41810134
Acute respiratory infection (COVID-19) risk prediction in travelers: A random forest model.Infectious Disease Modelling · 2026 not_reported Percentage Comparison 0.7percent vs 2.0percent PMID 41810134
Acute respiratory infection (COVID-19) risk prediction in travelers: A random forest model.Infectious Disease Modelling · 2026 not_reported Percentage Comparison 0.3percent vs 2.4percent PMID 41810134
Effectiveness of the school-based internet intervention StresSOS for the prevention of mental health problems in young people: a randomized controlled trial as part of the ProHEAD consortium.Journal of child psychology and psychiatry, and allied disciplines · 2026 not_reported Odds Ratio 0.7 p = .01 PMID 41821499
Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage76.8%234 records have no COI statement exposed in PubMed.
Funding metadata coverage21.3%Coverage indicates whether grant/funding metadata was present, not independence or study quality.
Most frequently reported funding agencies
NIAID NIH HHS44
NHLBI NIH HHS20
NCI NIH HHS18
NIH HHS16
National Natural Science Foundation of China14
NIDDK NIH HHS14
NIDA NIH HHS10
NIA NIH HHS9
View records with declared financial or industry relationships 12

The real-world economic impact of herpes zoster disease in patients with selected underlying conditions in Spain.

Helena Moza Moríñigo declares having received consulting fees from GSK for her participation in this study. Andrea García, Eleftherios Zarkadoulas, María Del Rosario Cambronero Mártinez, Javier Varas and Laura Amanda Vallejo-Aparicio are employees of GSK. Eleftherios Zarkadoulas, Javier Varas, María Del Rosario Cambronero Mártinez and Laura Amanda Vallejo-Aparicio hold financial equities in GSK. Alba Martín, María García, Alfonsina Trento and Ignacio Hernández are employees of Atrys Health. All authors declare no other financial or non-financial relationships or activities.

PMID 41656881 · 2026

Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients.

Funding Support and Author Disclosures This study has received funding from the Canadian Venous Thromboembolism Research Network (CanVECTOR) and the Department of Clinical Research, University of Bern. The funders had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Dr Tritschler has received research grants from CanVECTOR, the University of Bern, and the Swiss National Science Foundation. Dr Farkouh has received institutional research grants from Amgen, AstraZeneca, Novo Nordisk, and Novartis; has received consulting fees from Otitopic; and has received honoraria from Novo Nordisk. Dr Marx has received research grant support from the Swiss National Science Foundation (P500PM_230637) and the Swiss Society of General Internal Medicine Foundation. Dr Neal has received grants from the National Institutes of Health (NIGMS and National Heart, Lung, and Blood Institute) and the United States Department of Defense; has received consulting fees from Octapharma, Cellphire, and Takeda; has received honoraria from Haemonetics; and serves as Chief Medical Officer for Haima Therapeutics. Dr Sholzberg has received unrestricted research funding (to institution) from Pfizer and Octapharma; and has received honoraria for speaking engagements with Octapharma, Sobi, Werfen, and Roche. Dr Spyropoulos has received research grants from AstraZeneca and Grifols; has received consulting fees from AstraZeneca, Janssen, Grifols, Daiichi, Serb Pharmaceuticals, Regeneron, Novartis, and Roche Pharmaceuticals; and serves in unpaid leadership roles with the ATLAS Group and VascuLearn. Dr Muñoz-Rivas has received free drug supply from Leo Pharma for the PROTHROMCOVID; has received consultancy fees from Boehringer Ingelheim, Aspen, and Bayer; and has received lecture fees from Leo Pharma, Rovi, Sanofi, Bayer, and Boehringer Ingelheim. Dr Blondon has received research grants from the Swiss National Science Foundation and the Fondation Privée des Hôpitaux Universitaires de Genève; has received travel support from SOBI; and has participated on the advisory board of the COBRRA study. Dr Bikdeli was supported by a Career Development Award from the American Heart Association and VIVA Physicians (#938814) and the Scott Schoen and Nancy Adams IGNITE Award; is supported by the Mary Ann Tynan Research Scientist award from the Mary Horrigan Connors Center for Women’s Health and Gender Biology at Brigham and Women’s Hospital, the Brigham and Women’s Hospital’s Eleanor and Miles Shore Award, and the APS Foundation of America; is a member of the Medical Advisory Board for the VasuLearn Network; serves in the Data Safety and Monitory Board of the NAIL-IT trial funded by the National Heart, Lung, and Blood Institute, and Translational Sciences; is a collaborating consultant with the International Consulting Associates and the U.S. Food and Drug Administration in a study to generate knowledge about utilization, predictors, retrieval, and safety of IVC filters; receives compensation as an Associate Editor for the New England Journal of Medicine Journal Watch Cardiology, as an Associate Editor for Thrombosis Research, and as an Executive Associate Editor for JACC; and is a Section Editor for Thrombosis and Haemostasis (no compensation). Dr Cushman has received research grant support from the National Institutes of Health; and served as a Councilor for the International Society on Thrombosis and Haemostasis, with coverage of meeting travel and meals. Dr Goldin has received grants or contracts from Janssen Scientific Affairs and AstraZeneca, paid to his institution. Dr Goligher receives salary support for research through a grant from the National Sanitarium Association; and has funding unrelated to this work from CIHR. Dr Hochman has received grant support from the National Heart, Lung, and Blood Institute; and has received honoraria for service as a member of the CONNECTS Steering Committee. Dr Morici has received honoraria from AstraZeneca and Zoll. Dr Aujesky has received grant support from the Swiss National Science Foundation; participated on the PEITHO-3 Data Safety Monitoring Board; and has received free drug supply from Bayer SA for an unrelated trial. Dr Carrier has received grants from Pfizer, paid to his institution; and has received consulting fees from Regeneron, Anthos, Pfizer, Bristol Myers Squibb, Leo Pharma, Sanofi, and Valeo, with all payments made to his institution. Dr Stone has received speaker honoraria from Medtronic, Amgen, Boehringer Ingelheim; has served as a consultant to Robocath, Daiichi-Sankyo, Vectorious, Miracor, Millennia Biopharma, Apollo Therapeutics, Cardiac Success, Occlutech, Ablative Solutions, Oxitope, Elixir, Impulse Dynamics, Asceneuron, Myochron, Vesalio, Remote Cardiac Enablement, Valfix, Zoll, HeartFlow, Shockwave, Adona Medical, Abbott, HighLife, Elucid Bio, Aria, Alleviant, FBR Medical, Colibri, Bioventrix, and MedHub; has equity/options from Cardiac Success, Ancora, Cagent, Applied Therapeutics, Biostar family of funds, SpectraWave, Orchestra Biomed, Aria, Valfix, and Xenter; and his employer, Mount Sinai Hospital, receives research grants from Shockwave, Biosense-Webster, Bioventrix, Abbott, Abiomed, Cardiovascular Systems Inc, Phillips, Pulnovo, V-wave, and PCORI (via Weill Cornell Medical Center). Dr Le Gal has received honoraria from Emcure Pharma and Takeda for lectures or educational activities paid to his institution; and holds a Distinguished Clinical Researcher Chair on Diagnosis and Prevention of Venous Thromboembolism from the Department of Medicine, University of Ottawa. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

PMID 42523015 · 2026

Spatial and neighborhood data in the collaborative cohort of cohorts for COVID-19 Research (C4R).

The authors have read the journal’s policy and have the following competing interests: RGB is employed by the Department of Veterans Affairs, the positions and findings in this manuscript do not necessarily reflect those of the United States government. Dr. Buhr received personal fees from Viatris/Theravance Biopharma, DynaMed, and American College of Physicians, not related to this work. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.

PMID 42485397 · 2026

The use of patient-reported outcome questionnaires in patients with post-COVID-19 condition: a systematic review and meta-analysis.

Conflicts of interest: R.A.M., J.K., M.A., and H.K. work at the Evidence-based Practice and Impact Center at KUMC, which received funding under a contractual agreement with McMaster to coordinate the evidence reviews for the PCC diagnosis guidelines and to provide methods support. H.S. received funding from the Public Health Agency of Canada for this project as PI. R.N., W.W., and R.B.P.'s institution received funding from the Public Health Agency of Canada. R.N. received an honorarium for a guideline presentation. E.L.F. received a CAN-PCC honoraria and travel expenses. C.D.M. is a member of Pillar III for Long COVID Web and received an honorarium from CAN-PCC/McMaster/PHAC. G.Y.L. is a co-lead of the Long COVID Web clinical pillar and has received multiple grants and honoraria for Long COVID-related research. G.Y.L., R.K., G.Y.O., and A.V.C. are members of the CAN-PCC Guidelines Writing Committee, A.P. is a member of Pillar 3 of the Long COVID Web. R.K., G.Y.O., and A.V.C. are members of the Long COVID Web Symposium Planning Committee, and R.K. has received grants from Cochrane Canada and McMaster GRADE Centers at McMaster University and Saskatchewan Health Research Foundation (SHRF).

PMID 42536797 · 2026

Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial.

Declarations. Ethics approval and consent to participate: The institutional review boards of the University of Pennsylvania (Protocol #833400) and Chester County Hospital (Protocol ID CCH19-05 PENN #833400) approved this trial with a waiver of informed consent. Consent for publication: Not applicable. Competing interests: All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/disclosure-of-interest/ . and declare: MPK, MOH, DSS, YL, WW, BDF, MEM, TT, AMB, JAS, TK, KDR, RSB, SDH were given support from the National Heart, Lung and Blood Institute of the National Institutes for Health for the submitted work; KJR has received grants, honoraria and support for meeting travel from the American Association for Respiratory Care, Society for Critical Care Medicine, and California Society for Respiratory Care; MOH and FL have received research funding from Patient-Centered Outcomes Research Institute; MOH has received fees for statistical consulting from Elsevier, the American Thoracic Society, Unlearn.AI, and Guidepoint LLC, has participated on a Data Safety and Monitoring Board for the University of California San Francisco and the University of Pittsburgh, and has received honoraria for pilot grant reviews by the National Institute of Aging; no other relationships or activities that could appear to have influenced the submitted work.

PMID 42098760 · 2026

Prophylaxis against covid-19: living systematic review and network meta-analysis.

Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: BS reports receiving funding from PIPRA AG (www.pipra.ch) to conduct a systematic review and individual patient data meta-analysis on predictors of postoperative delirium in elderly people in 2020-21; funding from Mitacs Canada, Accelerate internship in partnership with Nestlé Canada to support his graduate student stipend from 2016 to 2018. Mitacs is a national, not-for-profit organisation that has designed and delivered research and training programmes in Canada, working with universities, companies, and both federal and provincial governments; and funding from the International Life Sciences Institute (ILSI)-North America to support his graduate work for his 2015 academic year. In 2016-17, BS worked part-time for the Cornerstone Research Group (CRG), a contract research organisation. The ILSI funding and being employed by CRG are outside the required three year period requested on the ICJME form. ML reports personal fees and non-financial support from Sanofi, grants and personal fees from Seqirus, and personal fees from Pfizer and Medicago outside the submitted work; and is co-investigator on an Anti-Coronavirus Therapies (ACT) randomised trial of covid-19 treatment. LG reports grants from the Ministry of Science and Technology of China, outside the submitted work. All other authors report no financial relationships with any organisations that might have an interest in the submitted work in the previous three years and no other relationships or activities that could appear to have influenced the submitted work.

PMID 33903131 · 2021

Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis.

Declarations. Competing interests: G.S.: speaker for Merck, Gilead, Abbvie, Novo Nordisk, Eli Lilly, Pfizer, and served as an advisory board member for Gilead, GlaxoSmithKline, Merck, Novo Nordisk. H.S.B.: Trial fees from Abbott, Amgen, Anji Pharmaceuticals, Arrowhead Pharmaceuticals, AstraZeneca, Boehringer Ingelheim, Eli Lilly, GlaxoSmithKline, Ionis Pharmaceuticals, Kowa Pharmaceuticals, Novartis, Novo Nordisk, Pfizer, Vertex. K.P.: Consultant and advisory board: Novo Nordisk, Merck, Boehringer-Ingelheim. Data Safety Committee: Gilead Sciences, Galectin. M.Betel: speaker for Medscape Education, Novo Nordisk, Boehringer and served as an advisory board member for PPD, Worldwide Clinical Studies, Regeneron, WebMD, Sonic Incytes and Madrigal. Fatty Liver Alliance has received unrestricted funding from Madrigal Pharmaceuticals, Novo Nordisk, Regeneron, Perspectum, Aegle Medical, Medscape, Echosens, PPD/Evidera, Siemens-Healthineers, Mind-Ray. S.S. has served as an advisory board member and consultant for Novo Nordisk. No conflicts were reported by the following authors: J.B., M.D., J.A.F., W.W.L.W., Z.L., M.B., A.N., Z.R.G., and E.E.M.M.

PMID 42056181 · 2026

Vitamin D in Gut and Systemic Immune Tolerance and in Infections' Risk: An International Evidence-Based Consensus Statement.

Declarations. Conflicts of interest/Competing interests: A.G. has occasionally consulted for Abiogen. L.D.F. received research grant to Institution from Abiogen and his research activities are partly supported by Glucocorticoid induced Osteoporosis Skeletal (GIOSEG); J.P.B. is a consultant for Abiogen, Amgen, Ascendis, and Radius. All authors: Transportation to and accommodation during Conference covered by Abiogen.

PMID 41886256 · 2026
01

Current Standard-of-Care Sources

Alexandria uses this label only for PubMed-indexed guidelines or consensus documents. These are source publications, not individualized recommendations.

02

Highest-Priority Research

meta analysisn=192158

Psychological and Cognitive Sequelae of COVID-19: Systematic Review and Meta-Analysis.

Journal of psychiatric and mental health nursing · 2026

INTRODUCTION: COVID-19 pandemic has exacerbated global mental health problems with the development of persistent symptoms. AIM: To conduct a prevalence meta-analysis of persistent psychological and cognitive sequelae of COVID-19 based on cohort studies. METHOD: This study followed PRISMA. Cohort studies that followed individuals for at least 12 weeks post-COVID-19 were included and pediatric studies were excluded. The databases Embase, Lilacs/BVS, PubMed, SciELO and Scopus were searched in November 2023. Meta-analyses were performed with subgroup analyses conducted. Results were presented with forest plot graphs and tables. Risk of bias and methodological quality were assessed using Eggers's…

PMID 42101066
clinical guideline

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026

BACKGROUND: This guideline aims to address key clinical questions of long COVID, and to provide evidence-based recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses and general practitioners in community healthcare institutions worldwide. METHODS: The guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinary working group was established and comprised 60 members from 10 countries and 10 areas of expertise, with a strong background in long COVID research and clinical practice, and met…

PMID 41856572
meta analysisn=380191

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Preventive medicine · 2026

OBJECTIVE: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D) and a marker of delayed diagnosis, associated with significant morbidity, mortality, and healthcare costs. Global estimates of DKA at T1D onset remain inconsistent. METHODS: We conducted a systematic review and meta-analysis, searching PubMed (1996), Web of Science (1966), Embase (1947), and Scopus (1980), each from its inception to October 2025, without restrictions. Studies reporting DKA prevalence at diagnosis in individuals <19 years with newly diagnosed T1D were included. Pooled prevalence was calculated using random-effects meta-analysis. Subgroup analyses explored variations by country, …

PMID 42303108
clinical guideline

Pragmatic management of acute cough in children and adolescents: an updated position paper by the Italian Society of Pediatric Allergy and Immunology (SIAIP).

Allergologia et immunopathologia · 2026

BACKGROUND: Cough is one of the most common and distressing symptoms in pediatric practice and represents a major cause of medical consultation, parental anxiety, and inappropriate medication use. Although most acute cough episodes are benign and self-limiting, they can significantly affect child's sleep, school performance, and quality of life. The COVID-19 pandemic and subsequent changes in infection patterns and immune responses have further highlighted the need to update the existing clinical guidance. OBJECTIVE: This joint position paper by the Italian Society of Pediatric Allergy and Immunology (SIAIP) aims to provide a pragmatic, evidence-based update on the management of acute and po…

PMID 42115792
clinical guideline

COVID-19 Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians.

Annals of internal medicine · 2026

DESCRIPTION: The American College of Physicians (ACP) developed these rapid practice points addressing the effectiveness, comparative effectiveness, and harms of Omicron-adapted COVID-19 vaccines in adults (aged ≥18 years) who are not pregnant or immunocompromised. METHODS: The ACP Population Health and Medical Science Committee developed the rapid practice points on the basis of a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria and national disease surveillance data on the epidemiology and baseline risks for COVID-19. UNLABELLED: The following practice points apply to those who are not pregnant or immunocompromised. PRACTICE POINT 1: Adults aged 65 years or older sho…

PMID 41730216
clinical guideline

Outpatient Treatment of Confirmed COVID-19 in Symptomatic Adults: Living, Rapid Practice Points From the American College of Physicians (Version 3).

Annals of internal medicine · 2026

DESCRIPTION: The American College of Physicians (ACP) maintains living, rapid practice points on antiviral treatment in the outpatient setting for COVID-19. METHODS: The Population Health and Medical Science Committee (PHMSC) developed this version 3 based on evidence from a focused update of a living, rapid review conducted by the ACP Center for Evidence Reviews at Cochrane Austria. This version addresses the SARS-CoV-2 Omicron variant and reaffirms previous practice points on the use of antiviral treatments of confirmed COVID-19 in unvaccinated or vaccinated and symptomatic patients in the outpatient setting. PRACTICE POINT 1: Consider nirmatrelvir-ritonavir combination therapy to treat sy…

PMID 41662713
meta analysisn=323440

Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.

Journal of affective disorders · 2026

BACKGROUND: Depression and anxiety constitute a global health crisis, with prevalence increasing by 27.6% during the COVID-19 pandemic. The 24-Hour Movement Guidelines, integrating physical activity, sedentary behavior, and sleep, have been linked to improved mental health, yet no meta-analysis has quantified these associations. METHODS: Following PRISMA guidelines, PubMed, Embase, Cochrane Library, and Web of Science were searched through January 1, 2026. Observational studies examining adherence to the 24-Hour Movement Guidelines and anxiety or depression were included. Cross-sectional and cohort studies were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools, with t…

PMID 42203050
systematic reviewn=327298

Interventions to Enhance COVID-19 Pandemic Health Literacy in Health Professionals: Systematic Review.

JMIR medical education · 2026

BACKGROUND: The COVID-19 pandemic has placed a significant burden on health professionals (HPs). They face higher infection risks due to the nature of their work environment and patient care responsibilities. Their ability to access and apply reliable COVID-19 information affects their own preventive behavior and that of those around them. In this context, health literacy (HL) has become increasingly important. Despite extensive research, information to foster COVID-19-related HL in HPs remains limited. OBJECTIVE: This systematic review aimed to identify, appraise, and synthesize intervention studies on the effectiveness of COVID-19-related HL interventions in HPs. METHODS: Five electronic d…

PMID 42430764
clinical guideline

Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements.

Blood purification · 2025

Extracorporeal blood purification is a technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration, and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus statements for the use of the oXiris filter based on a comprehensive review of publications. After evaluation using a Delphi methodology, 17 statements achieved consensus (three recomm…

PMID 40929000
meta analysisn=24582

Global distribution of fungal rhinosinusitis.

Rhinology · 2026

BACKGROUND: Fungal rhinosinusitis (FRS) comprises subtypes with varying epidemiology and outcomes. Global comparative data remain limited. METHODS: Following PRISMA guidelines (CRD42023481670), a systematic review and meta-analysis was conducted. Cases were categorized into seven subtypes to assess variation across regions. RESULTS: 2,031 studies (40,860 cases, 77 countries) were included. Non-invasive forms accounted for 60% (n=24,582) of cases, mainly fungal ball (35%, n=14,280) and allergic FRS (25%, n=10,302). Invasive subtypes were more frequent in tropical climates, with the hyperacute rhino-orbito-cerebral mucormycosis predominating. This subtype differed from acute and subacute invas…

PMID 41785015
systematic reviewn=20793

Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis.

Reviews in medical virology · 2026

The efficacy of convalescent plasma (CP) in COVID-19 has been contested, with large randomized trials producing conflicting results that led to recommendations against routine use. We performed a systematic review with design-stratified narrative synthesis (PRISMA 2020; SWiM; OSF: https://osf.io/tjcuq) to test whether these conflicting outcomes can be reconciled through three interacting determinants-timing, antibody titre, and host characteristics-using a standardized 91-field extraction matrix applied to each study. PubMed, Web of Science, and Scopus were searched through May 2026. Thirty-one studies (20,793 patients; 8 RCTs, 23 observational) were included. The synthesis indicates that CP…

PMID 42536815
meta analysisn=16994

Pharmacological thromboprophylaxis in hospitalized patients with acute infectious diseases: a meta-analysis.

European journal of clinical pharmacology · 2026

INTRODUCTION: Venous thromboembolism (VTE) may be a significant complication in medical patients, and infectious disease has been highlighted as an additional risk factor. Pharmacological thromboprophylaxis can prevent VTE and is recommended in at-risk populations, but not routinely in patients with infectious diseases. METHODS: We conducted a systematic review and meta-analysis of studies on the effectiveness of pharmacological thromboprophylaxis in patients with acute infections, excluding those involving COVID-19. The primary outcome was VTE events. Secondary outcomes were mortality and adverse events related to anticoagulant therapy. RESULTS: Data from seven studies (four randomized cont…

PMID 42479201
03

Latest Research — Last 24 Months

04

Treatment Options Studied in the PubMed Collection

These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.

higher-confidence evidence

COVID-19 Vaccines

96 linked PMIDs7114964 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization, recurrence, rebound, long COVID
Populations represented
general population; children; neutralizing antibody; localized; older adults; severe COVID-19
Mechanism
Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Least commonly encountered by participants (n = 328, 31.7%) was a person 'Thinking that others are targeting them in order to bully or exploit them, and so isolating from the world and refusing to leave their home'
PMID 39971395PMID 41785679PMID 41630128PMID 42057741PMID 42432642PMID 42503519PMID 41905519PMID 36596943
higher-confidence evidence

COVID-19 vaccine

40 linked PMIDs87586 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, hospitalization, serious adverse events, mortality
Populations represented
general population; children; older adults; severe COVID-19; severe COVID-19; older adults; neutralizing antibody
Mechanism
CONCLUSION: Targeting BeSD factors related to confidence in vaccine benefits, family norms, and parent/caregivers' vaccination intentions could help address barriers to routine childhood COVID-19 vaccination, potentially improving COVID-19 vaccination rates among urban, healthcare-seeking caregivers in similar study settings BACKGROUND: Using adapted COVID-19 vaccines targeting current variants in circulation is necessary for addressing the dynamic evolution of the SARS-CoV-2 virus and protecting against emerging variants
PMID 41785679PMID 42057741PMID 37997650PMID 34171345PMID 41680545PMID 42324927PMID 42437699PMID 42518305
moderate-confidence evidence

Antibodies, Viral

36 linked PMIDs79994 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, rebound, mortality
Populations represented
general population; neutralizing antibody; children; SARS-CoV-2 RNA; children; viral load
Mechanism
Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Here, we evaluated a poly (lactic-co-glycolic acid) (PLGA) microparticle-based vaccine co-encapsulating the receptor binding domain (RBD) of SARS-CoV-2 Spike protein with the TLR3/RIG-1 agonist Riboxxim, employing a subcutaneous prime and intranasal boost immunization schedule
PMID 42536815PMID 41785679PMID 41875666PMID 35742506PMID 42084498PMID 42378965PMID 41919612PMID 42118165
moderate-confidence evidence

Antiviral Agents

29 linked PMIDs8202 reported cumulative sample signal
Research status
mostly neutral
Outcomes represented
reported clinical outcomes, adverse events, mortality, long COVID, quality of life, serious adverse events, mechanical ventilation
Populations represented
general population; long COVID; moderate COVID-19; severe COVID-19; viral load; neutralizing antibody
Mechanism
The COVID-19 pandemic highlighted the urgent necessity for effective therapeutic agents targeting SARS-CoV-2 This study integrates network pharmacology, identifying 335 shared targets between C. fenestratum alkaloids and SARS-CoV-2 host proteins; molecular docking across five hub targets; SiteMap analysis confirming a druggable STAT3 binding cavity (D-score = 1.01); 100 ns MD simulations demonstrating complex stability (RMSD < 3 Å, RMSF <1.2 Å); and MM/GBSA refinement positioning the tembetarine-STAT3 interaction as the lead candidate (binding free energy ΔG_bind = -41.47 kcal/mol)
PMID 41869741PMID 42450260PMID 42081967PMID 42263552PMID 41967451PMID 42285451PMID 42455170PMID 41481484
limited evidence

Spike Glycoprotein, Coronavirus

27 linked PMIDs646 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, mortality
Populations represented
general population; neutralizing antibody; children; severe COVID-19; older adults; viral load
Mechanism
Here, we evaluated a poly (lactic-co-glycolic acid) (PLGA) microparticle-based vaccine co-encapsulating the receptor binding domain (RBD) of SARS-CoV-2 Spike protein with the TLR3/RIG-1 agonist Riboxxim, employing a subcutaneous prime and intranasal boost immunization schedule The primary targets of SARS-CoV-2 are lung cells, where viral-host interactions trigger extensive molecular and structural changes
PMID 42467522PMID 42161120PMID 41919612PMID 42287949PMID 42302372PMID 42308256PMID 42361718PMID 42372164
limited evidence

spike protein, SARS-CoV-2

22 linked PMIDs486 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population; children; neutralizing antibody; severe COVID-19; older adults; viral load
Mechanism
Here, we evaluated a poly (lactic-co-glycolic acid) (PLGA) microparticle-based vaccine co-encapsulating the receptor binding domain (RBD) of SARS-CoV-2 Spike protein with the TLR3/RIG-1 agonist Riboxxim, employing a subcutaneous prime and intranasal boost immunization schedule This integrated, one-pot, and scalable platform provides a versatile strategy for fast, sensitive, and multimodal nucleic acid detection applicable to diverse targets
PMID 42467522PMID 41919612PMID 42330669PMID 42287949PMID 42308256PMID 42361718PMID 42372164PMID 42519305
moderate-confidence evidence

Influenza Vaccines

16 linked PMIDs69646 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events, mortality, hospitalization
Populations represented
general population; older adults; children; neutralizing antibody; C-reactive protein; children
Mechanism
Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2 Primary objectives were to demonstrate noninferiority of mRNA-1083 versus comparators for influenza hemagglutination inhibition (HAI) responses and SARS-CoV-2 neutralizing antibody (nAb; PsVNA) responses at Day 29 after vaccination and to evaluate safety and reactogenicity of study vaccines
PMID 42370650PMID 41734040PMID 42378965PMID 41686169PMID 42518305PMID 42522246PMID 41627968PMID 41661551
moderate-confidence evidence

Antibodies, Neutralizing

16 linked PMIDs54571 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, mortality, adverse events, serious adverse events
Populations represented
general population; neutralizing antibody; children
Mechanism
Pseudovirus neutralizing antibody geometric mean fold rise (GMFR) responses against SARS-CoV-2 (D614G) at Day 29 and Day 181, respectively, among those ≤60 years were 5.2 (95% CI 2.1, 13.3) and 6.1 (2.8, 13.2) after 3 μg, and 3.6 (1.3, 10.4) and 2.4 (0.2, 33.0) after 6 μg Neutralizing antibody titers assessed via focus reduction neutralization test against SARS-CoV-2 D614G largely mirrored the PsVNA findings
PMID 41785679PMID 42423335PMID 42519305PMID 42522246PMID 39990674PMID 41740461PMID 42511517PMID 42539595
higher-confidence evidence

Immunoglobulin G

16 linked PMIDs833 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, long COVID
Populations represented
general population; children; neutralizing antibody; SARS-CoV-2 RNA; children; long COVID
Mechanism
Nipocalimab binds to FcRn with high specificity and affinity, eliciting increased clearance of IgG antibodies without affecting IgG production or other immune functions Vaccination induced a robust humoral response, with high post-vaccination anti-spike IgG levels (median 988.69 BAU/mL), 97.44% seropositivity, 96.88% true seroconversion among baseline IgG-/NAb- patients, and strong neutralizing antibody activity (median 85.73%)
PMID 37393304PMID 35742506PMID 42084498PMID 42378965PMID 42118165PMID 42184776PMID 41739906PMID 41605700
preliminary evidence

Biomarkers

13 linked PMIDs6044 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, symptom duration, hospitalization, mortality, mechanical ventilation
Populations represented
general population; severe COVID-19; older adults; severe COVID-19; advanced; C-reactive protein; C-reactive protein; children
Mechanism
Conclusions: These findings contribute to a better understanding of cf-mtDNA's role in COVID-19 pathogenesis, its potential as a promising biomarker, and pave the way for the identification of new therapeutic targets Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment
PMID 42525082PMID 42415070PMID 41263641PMID 41966795PMID 42361718PMID 41362990PMID 41839271PMID 41902764
preliminary evidence

RNA, Viral

13 linked PMIDs1496 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, mortality, mechanical ventilation, rebound, hospitalization
Populations represented
general population; SARS-CoV-2 RNA; viral load; children
Mechanism
The NeuMoDx™ assay demonstrated strong correlations between Ct values and viral RNA concentrations, with R² values of 0.9971 and 0.9952 for the N and Nsp2 targets, respectively Intra-run precision showed low variability, with standard deviations of 0.23 and 0.34 at 500 copies/mL for the N and Nsp2 targets, respectively
PMID 42161120PMID 42184674PMID 42309186PMID 42361718PMID 40768948PMID 42119158PMID 42247945PMID 42538539
moderate-confidence evidence

Vaccines, Synthetic

12 linked PMIDs10589 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
adverse events, serious adverse events, reported clinical outcomes, mortality
Populations represented
general population; neutralizing antibody; severe COVID-19; older adults
Mechanism
Vaccination induced a robust humoral response, with high post-vaccination anti-spike IgG levels (median 988.69 BAU/mL), 97.44% seropositivity, 96.88% true seroconversion among baseline IgG-/NAb- patients, and strong neutralizing antibody activity (median 85.73%) As a primary regimen, the Flu‑CoV2 vaccine effectively induced strong IgG and neutralizing antibody responses against both influenza and SARS‑CoV‑2
PMID 41627968PMID 42268674PMID 42155675PMID 42379196PMID 42423335PMID 42511517PMID 42539595PMID 41744151
limited evidence

Angiotensin-Converting Enzyme 2

11 linked PMIDs200 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population; viral load
Mechanism
Inhibition of JAK1 by 4-OI will therefore block ACE2 expression as well as other effects driven by JAK1, highlighting a dual capability of itaconate derivatives such as 4-OI for having antiviral and anti-inflammatory effects, which could have therapeutic utility in COVID-19 This single-step platform offers the potential for adaptation to other viral targets
PMID 42467522PMID 42429254PMID 42287949PMID 42308256PMID 42455170PMID 40674406PMID 42044812PMID 42235192
preliminary evidence

BNT162 Vaccine

10 linked PMIDs4859 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
adverse events, reported clinical outcomes, mortality, hospitalization, recurrence
Populations represented
general population; children; older adults; severe COVID-19
Mechanism
BACKGROUND: Using adapted COVID-19 vaccines targeting current variants in circulation is necessary for addressing the dynamic evolution of the SARS-CoV-2 virus and protecting against emerging variants RESEARCH DESIGN AND METHODS: Using a previously published, combined Markov-decision tree model adapted for Costa Rica, this study estimated the outcomes of different vaccination strategies with BNT162b2 COVID-19 mRNA vaccine, targeting various age and risk groups
PMID 42430326PMID 41848549PMID 42435835PMID 42027105PMID 42535780PMID 41711397PMID 41764030PMID 42118165
limited evidence

ACE2 protein, human

10 linked PMIDs200 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population; viral load
Mechanism
Inhibition of JAK1 by 4-OI will therefore block ACE2 expression as well as other effects driven by JAK1, highlighting a dual capability of itaconate derivatives such as 4-OI for having antiviral and anti-inflammatory effects, which could have therapeutic utility in COVID-19 This single-step platform offers the potential for adaptation to other viral targets
PMID 42429254PMID 42287949PMID 42308256PMID 42455170PMID 40674406PMID 42044812PMID 42235192PMID 42435246
moderate-confidence evidence

2019-nCoV Vaccine mRNA-1273

8 linked PMIDs10550 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
adverse events, serious adverse events, reported clinical outcomes, mortality, hospitalization, rebound
Populations represented
general population; severe COVID-19; older adults; severe COVID-19; viral load
Mechanism
While the original mRNA COVID-19 vaccine, mRNA-1273, targets the full-length SARS-CoV-2 spike protein, mRNA-1283 is a novel next-generation mRNA COVID-19 vaccine that specifically targets immunodominant domains within the spike protein
PMID 41627968PMID 42154963PMID 41744151PMID 41764030PMID 41935967PMID 42018766PMID 42220116PMID 42477513
limited evidence

Coronavirus 3C Proteases

8 linked PMIDs1030 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes, adverse events, serious adverse events
Populations represented
general population; severe COVID-19
Mechanism
To explore DAL's potential antiviral activity against SARS-CoV-2, we performed molecular docking and molecular dynamics simulations targeting the main viral protease (Mpro) The organoselenium drug Ebselen has shown potent in vitro inhibition of Mpro as well as antiviral activity, granting clinical interest as a COVID-19 treatment option
PMID 41689234PMID 42285451PMID 41481484PMID 42002052PMID 42102470PMID 42235189PMID 42269456PMID 42127390
preliminary evidence

mRNA Vaccines

8 linked PMIDs87 reported cumulative sample signal
Research status
insufficiently reported
Outcomes represented
reported clinical outcomes
Populations represented
general population; advanced; neutralizing antibody
Mechanism
Preclinical and clinical studies now demonstrate potent and durable immune responses elicited by LNP-mRNA vaccines against diverse viral, bacterial, and cancer targets Yet, challenges such as complex antigen expression, mucosal targeting, and immune durability persist
PMID 42379196PMID 41791686PMID 41962202PMID 42541646PMID 42318873PMID 41740461PMID 42511517PMID 42083894
05

Conflicting Research

higher-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

78 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 72harm: 5null: 1
PMID 42142525PMID 39971395PMID 41785679PMID 41630128PMID 42057741PMID 42220116PMID 42432642PMID 42503519PMID 41905519PMID 42390526
higher-confidence evidence

COVID-19 vaccine · multiple reported outcomes

31 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 27null: 1harm: 3
PMID 42142525PMID 41785679PMID 42057741PMID 42220116PMID 37997650PMID 34171345PMID 41680545PMID 42324927PMID 42155675PMID 42437699
higher-confidence evidence

Antibodies, Viral · multiple reported outcomes

23 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 21harm: 1null: 1
PMID 42536815PMID 41785679PMID 42220116PMID 41875666PMID 42390526PMID 41627968PMID 35742506PMID 41569047PMID 42084498PMID 42268674
higher-confidence evidence

Antiviral Agents · multiple reported outcomes

22 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
benefit: 1unknown: 18null: 2mixed: 1
PMID 40067859PMID 34837230PMID 42017206PMID 41869741PMID 42316440PMID 42433209PMID 42450260PMID 42081967PMID 42104169PMID 42263552
moderate-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

9 studies

Status: apparently conflicting; different clinical questions. Population: children. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 7harm: 1null: 1
PMID 41911278PMID 42053343PMID 42251204PMID 41814863PMID 42535943PMID 42223472PMID 42027105PMID 42535780PMID 42486492
higher-confidence evidence

remdesivir · multiple reported outcomes

7 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 5null: 1mixed: 1
PMID 40067859PMID 42017206PMID 42316440PMID 42446369PMID 42322756PMID 42455170PMID 42542690
higher-confidence evidence

Adenosine Monophosphate · multiple reported outcomes

5 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 3null: 1mixed: 1
PMID 40067859PMID 42017206PMID 42316440PMID 42322756PMID 42455170
preliminary evidence

Antibodies, Viral · multiple reported outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: children. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
harm: 1unknown: 2null: 1
PMID 41956300PMID 42223472PMID 42027105PMID 41980656
moderate-confidence evidence

Drug Combinations · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: not reported.

  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
benefit: 1null: 1unknown: 1
PMID 34837230PMID 41869741PMID 42536986
moderate-confidence evidence

Alanine · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
unknown: 2mixed: 1
PMID 40067859PMID 42316440PMID 42322756
preliminary evidence

Spike Glycoprotein, Coronavirus · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: children. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
harm: 1unknown: 1null: 1
PMID 41956300PMID 42223472PMID 41980656
moderate-confidence evidence

Adrenal Cortex Hormones · multiple reported outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

  • The records use different or inconsistently reported comparators.
  • The records report different endpoints or outcome definitions.
  • The evidence combines different study designs.
  • Some abstracts do not state whether the primary endpoint was met.
harm: 1null: 1
PMID 42425738PMID 42385526
06

Failed or Negative Trials

07

Emerging and Experimental Research

08

Evidence Gaps

Detailed risk-of-bias assessment remains limited

PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.

R

Complete Ranked PubMed Index

The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.

Current Standard Of Care62 records
Rank112.0
Clinical guideline or consensus statement

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026 · PMID 41856572

BACKGROUND: This guideline aims to address key clinical questions of long COVID, and to provide evidence-based recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses and general practitioners in community healthcare institutions worldwide. METHODS: The guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinar…

Rank110.0
Clinical guideline or consensus statementResult signal: harm

COVID-19 Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians.

Annals of internal medicine · 2026 · PMID 41730216

DESCRIPTION: The American College of Physicians (ACP) developed these rapid practice points addressing the effectiveness, comparative effectiveness, and harms of Omicron-adapted COVID-19 vaccines in adults (aged ≥18 years) who are not pregnant or immunocompromised. METHODS: The ACP Population Health and Medical Science Committee developed the rapid practice points on the basis of a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria and national disease surveillance data on the epidemiology and …

Rank110.0
Clinical guideline or consensus statement

Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements.

Blood purification · 2025 · PMID 40929000

Extracorporeal blood purification is a technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration, and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus stat…

Rank110.0
Clinical guideline or consensus statement

Outpatient Treatment of Confirmed COVID-19 in Symptomatic Adults: Living, Rapid Practice Points From the American College of Physicians (Version 3).

Annals of internal medicine · 2026 · PMID 41662713

DESCRIPTION: The American College of Physicians (ACP) maintains living, rapid practice points on antiviral treatment in the outpatient setting for COVID-19. METHODS: The Population Health and Medical Science Committee (PHMSC) developed this version 3 based on evidence from a focused update of a living, rapid review conducted by the ACP Center for Evidence Reviews at Cochrane Austria. This version addresses the SARS-CoV-2 Omicron variant and reaffirms previous practice points on the use of antiviral treatments of co…

Rank110.0
Clinical guideline or consensus statement

Pragmatic management of acute cough in children and adolescents: an updated position paper by the Italian Society of Pediatric Allergy and Immunology (SIAIP).

Allergologia et immunopathologia · 2026 · PMID 42115792

BACKGROUND: Cough is one of the most common and distressing symptoms in pediatric practice and represents a major cause of medical consultation, parental anxiety, and inappropriate medication use. Although most acute cough episodes are benign and self-limiting, they can significantly affect child's sleep, school performance, and quality of life. The COVID-19 pandemic and subsequent changes in infection patterns and immune responses have further highlighted the need to update the existing clinical guidance. OBJECTIV…

Rank105.0
Systematic review or meta-analysis

Nebulized Heparin in Adults With Acute Respiratory Failure: A Meta-Analysis of Randomized Trials.

Critical care medicine · 2026 · PMID 42148826

OBJECTIVES: Dysregulated pulmonary coagulation and inflammation is a hallmark of respiratory failure in various etiologies. Excessive fibrin deposition contributes to alveolar collapse, impaired gas exchange, and progression to pulmonary fibrosis. Nebulized heparin can mitigate these coagulation and inflammation disturbances. Although several randomized controlled trials have explored its effects, results remain inconsistent and limited by small patient populations. We conducted a random-effects meta-analysis to ca…

Rank100.0
Systematic review or meta-analysis

Factors and mitigating strategies impacting receipt of healthcare by the Deaf community: an umbrella review.

BMC health services research · 2026 · PMID 41952170

BACKGROUND: Despite over 70 million Deaf people using sign languages worldwide, their ability to access and receive health services remains disproportionately limited. The Deaf community commonly encounter reduced access to preventive care compared to the hearing population. This umbrella review aims to collate and appraise systematic reviews examining factors and mitigating strategies influencing Deaf people’s receipt of healthcare. METHODS: The protocol was registered in PROSPERO (CRD42024563083). Eligible system…

Rank100.0
Systematic review or meta-analysis

Digital Strategies Utilised to Encourage Undergraduate Nursing Students' Engagement in Online Units of Study Throughout the COVID-19 Pandemic: A Systematic Review.

Nursing open · 2026 · PMID 41963630

AIM: This systematic review provides an overview of digital strategies utilised to encourage undergraduate nursing students' engagement in online units of study throughout the COVID-19 pandemic. BACKGROUND: In nursing education, engagement was crucial in acquiring knowledge, skills, critical thinking and problem-solving abilities. The COVID-19 pandemic forced schools and universities worldwide to quickly adapt from face-to-face learning to online platforms. While online teaching and digital technologies in educatio…

Rank100.0
Systematic review or meta-analysis

Can the Bergen Facebook Addiction Scale be adapted across contexts? Evidence from a COnsensus-based Standards for the selection of health Measurement INstruments systematic review.

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026 · PMID 41973776

OBJECTIVE: The Bergen Facebook Addiction Scale (BFAS) has served as a foundation for a series of adapted measures designed to assess social media-related behavioral addictions. Despite widespread application of these instruments, a systematic evaluation of their psychometric properties is lacking. This review aimed to evaluate the measurement properties of the BFAS and its adaptations using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology. METHOD: A systematic s…

Rank98.5
Randomized controlled trial

Effectiveness of intensive community care services for adolescents with acute psychiatric emergencies: findings from a feasibility multi-centre, parallel-group, single-blinded RCT.

Health technology assessment (Winchester, England) · 2026 · PMID 42148829

BACKGROUND: Adolescents experiencing psychiatric emergencies often require intensive interventions to prevent hospitalisation and support their return to education, employment or training. Intensive Community Care Services aim to provide an alternative to inpatient care. AIMS: To evaluate the effectiveness of Intensive Community Care Services compared to treatment as usual in reducing the time to start or return to education, employment or training for young people with psychiatric emergencies. METHOD: A multicentr…

Rank96.0
Systematic review or meta-analysis

Workforce shortages and supported access to medical care for hospital employees: a scoping review.

BMJ open · 2026 · PMID 42392626

OBJECTIVES: This scoping review synthesises peer-reviewed and grey literature on supported access to medical care for hospital employees with existing physical health complaints to understand how it may reduce sickness absenteeism by promoting sustainable employability and to identify gaps and opportunities to inform the design and implementation of organisational supported care frameworks. DESIGN: We conducted this scoping review following the Arksey and O'Malley framework and Levac et al's methodological recommen…

Rank92.0
Randomized controlled trial

Feasibility and preliminary effects of a yoga program developed for adults with post COVID-19 condition (Breathe Easy): Pilot randomized controlled trial.

Complementary therapies in medicine · 2026 · PMID 41921919

INTRODUCTION: Effective medical management of post COVID-19 condition (post COVID) remains challenging. Symptoms are heterogenous, debilitating, and impact health-related quality of life (HR-QoL). Complementary treatments are needed that can be self-managed and improve health. Yoga is a promising strategy that may help reduce post-COVID symptoms but remains understudied. METHODS: We co-designed a unique yoga intervention for adults with post COVID and evaluated its feasibility and preliminary effects. Two-group par…

Rank89.5
Randomized clinical study

Clinical checklists of multicomponent non-pharmacological interventions for delirium management in adult patients in non-ICU inpatient healthcare settings: a rapid review.

BMJ open · 2026 · PMID 42366006

OBJECTIVES: To identify clinical checklists of multicomponent non-pharmacological interventions for the prevention and treatment of delirium used in non-intensive care unit inpatient healthcare settings, their content and reported implementation. DESIGN: Rapid review. DATA SOURCES: Medline, Embase, PsycINFO, CINAHL and Cochrane CENTRAL were searched from 1 January 1999 to 31 March 2022 and updated on 16 January 2025. A comprehensive grey literature search, including websites of guideline development groups and inte…

Rank87.0
Randomized clinical study

International collaborations in neonatal and fetal medicine - Low-and-middle income countries have the patients and high-income countries have the technology: Consensus, conundrums and controversies.

Seminars in fetal & neonatal medicine · 2026 · PMID 42009582

International collaborations between investigators in low-and-middle-income countries (LMICs) and high-income countries (HICs) in neonatal and fetal medicine have expanded over the past decade. This narrative review documents a rise in HIC-LMIC publications since 2014, with a plateau and transient dip during the COVID-19 pandemic. It analyses leadership, patient recruitment, and how HIC-based technologies and laboratory platforms shape research agendas. Many influential trials are conceived and sponsored by HIC ins…

Rank85.0
Randomized clinical study

Operational strategies among infectious disease clinical trial sites during pandemics: a scoping review.

Trials · 2026 · PMID 41943131

PURPOSE: The aim of this study is to examine documented strategies, challenges, and lessons related to clinical trial site operations during pandemics. METHODS: This review focused on seven major pandemics: COVID-19, HIV/AIDS, Ebola, SARS, MERS, H1N1, and Zika. Searches were conducted using PubMed and Embase between September 2024 and February 2025, yielding 7572 unique records. After dual screening, 47 articles met inclusion criteria, with an additional 8 identified through citation searching, for a total of 55. N…

Rank79.2
Multicenter clinical study

Relationship between negative-pressure ICU rooms and the risk of COVID-19-associated pulmonary aspergillosis: an ancillary analysis of the COVID-ICU cohort study.

Critical care (London, England) · 2026 · PMID 42186034

BACKGROUND: COVID-19-associated pulmonary aspergillosis (CAPA) has emerged as a serious complication of severe SARS-CoV-2 pneumonia in critically ill patients requiring invasive mechanical ventilation (IMV). Several host- and treatment-related risk factors have been identified, but the role of environmental factors-particularly ICU room air pressure-remains underexplored. METHODS: We conducted an ancillary analysis of the COVID-ICU study, a prospective multicenter cohort of COVID-19 patients admitted to ICUs in Fra…

Rank65.9
Observational or cohort study

Association between prior COVID-19 infection and acute mountain sickness on Jade Mountain: A prospective observational study (2023-2024).

Journal of infection and public health · 2026 · PMID 41643499

BACKGROUND: Acute mountain sickness (AMS) is a frequent concern for climbers at high altitudes. Since the COVID-19 pandemic, questions have emerged regarding whether prior infection increases susceptibility to AMS. METHODS: We conducted a prospective observational study at the Paiyun Lodge medical station (3402 m) on Jade Mountain (Yushan, 3952 m) between 2023 and 2024. All climbers presenting for medical services were screened. Demographics, comorbidities, ascent characteristics, sleep duration, prophylactic medic…

Rank55.0
Other PubMed-indexed publicationResult signal: harm

Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis.

Scientific reports · 2026 · PMID 42056181

Adults with type 2 diabetes have increased risk of liver fibrosis, leading guidelines to recommend screening with the Fibrosis-4 Index (FIB-4). We assessed if modifications to Ontario Health Insurance Plan coverage of aspartate aminotransferase (AST) tests in 2013 were associated with changes in liver fibrosis assessment rates among adults with diabetes. This population-based cohort study included adults with diabetes and no history of liver disease in Ontario, Canada, from 2010 to 2022. Policy periods were constru…

Rank49.5
Other PubMed-indexed publication

Healthcare personnel masking: current practices and gaps in standardized thresholds.

Infection control and hospital epidemiology · 2026 · PMID 42187621

OBJECTIVE: To characterize institutional masking policies for healthcare personnel (HCP) and identify factors informing masking decisions in the post-COVID-19 pandemic era. DESIGN: Cross-sectional, survey-based study. SETTING: Healthcare institutions participating in the Society for Healthcare Epidemiology of America (SHEA) and Association for Professionals in Infection Control and Epidemiology (APIC) Research Networks. PARTICIPANTS: One representative per institution, including infection preventionists, hospital e…

Rank49.4
Other PubMed-indexed publication

Implanted Vascular Access Port Flush Frequency: Striking the Balance Between Patient Convenience and Clinical Safety.

Journal of infusion nursing : the official publication of the Infusion Nurses Society · 2026 · PMID 42065601

OBJECTIVE: Guidelines from the Oncology Nursing Society (ONS) and Infusion Nurses Society (INS) were reviewed to establish a flushing protocol. No consensus on implanted vascular access port (IVAP) flush frequency was recommended. Guidelines suggest extending up to 12 weeks may be safe based on functionality. However, limited research on the risks associated with stagnant reservoir contents leaves this practice under debate. METHODS: An oncology clinic studied IVAP flush practices during the COVID-19 pandemic when …

Rank49.4
Other PubMed-indexed publication

Maternity Care Experiences Among Birthing Women in Two European-Region Countries During the COVID-19 Pandemic: A Qualitative Study.

International journal of nursing practice · 2026 · PMID 41841158

BACKGROUND: Early in the COVID-19 pandemic, there was a lack of consensus regarding maternity care infection mitigation practices, including maternal-infant separation when COVID-19 was suspected or confirmed, partner presence and breastfeeding. AIM: To gain insight into the perceived maternity care and birth experiences of women during and following the COVID-19 pandemic in two neighbouring WHO European-Region countries. METHODS: Qualitative content analysis was conducted using the text responses to open-ended que…

Rank49.2
Other PubMed-indexed publication

Lessons from COVID-19 for improving delivery of medications for opioid use disorder in future pandemic events: results from a Puerto Rico Delphi consensus panel.

Harm reduction journal · 2026 · PMID 42002747

BACKGROUND: COVID-19 severely disrupted the provision of medications for opioid use disorder (MOUD) everywhere. Yet, while MOUD has proven to reduce mortality and other drug-related harms, no comprehensive guidelines exist to deliver treatment during a future pandemic. METHODS: From June to November 2023, (N = 12) stakeholders with professional backgrounds in MOUD delivery and policy, including one patient located in San Juan, Puerto Rico, were recruited to deliver policy recommendations on pandemic preparedness. A…

Rank48.7
Other PubMed-indexed publication

Genomic characterization of SARS-CoV-2 variants circulating in the population of Bangui, Central African Republic (CAR) in 2022.

Virology journal · 2026 · PMID 42210300

INTRODUCTION: With the ongoing global resurgence of COVID-19, it is crucial to better understand past transmission dynamics to strengthen national preparedness for future surges. Since its emergence in Wuhan, China, in December 2019, SARS-CoV-2 has caused multiple waves of infection worldwide. The World Health Organization (WHO) has identified several variants of concern, including Alpha, Beta, Gamma, and Delta. At the end of 2021, the Omicron variant emerged in South Africa and rapidly spread across the globe. Whi…

Rank48.6
Other PubMed-indexed publication

Within-host SARS-CoV-2 diversity in immunocompromised patients during acute infection.

Journal of virology · 2026 · PMID 42262131

UNLABELLED: Within-host SARS-CoV-2 diversity during acute infection is largely characterized by low-frequency intra-host single-nucleotide variants (iSNVs), but whether early iSNV patterns differ by immune status remains unclear. We analyzed biobanked diagnostic specimens from adults with RT-qPCR-confirmed SARS-CoV-2 infection collected in Cali, Colombia, between 2020 and 2022. Immunocompromised cases sampled during the acute phase were classified into four clinical categories, and immunocompetent cases from the sa…

Rank48.4
Other PubMed-indexed publication

Placental pathology of 153 SARS-CoV-2 positive women in relation to alpha, delta & omicron variations - a nested case-control study.

Placenta · 2026 · PMID 42107317

BACKGROUND: Maternal SARS-CoV-2 infection has been reported to coincide with specific placental lesions, yet the extent to which these changes differ between viral variants remains insufficiently explored. This study compares placental histopathology in SARS-CoV-2-positive pregnancies with SARS-CoV-2-negative controls and examines differences between Alpha, Delta, and Omicron variants. METHODS: This nested case-control study included placentas from 153 SARS-CoV-2-positive pregnancies from the PREGCO cohort at Hvido…

Diagnosis And Screening160 records
Rank110.0
Systematic review or meta-analysis

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Preventive medicine · 2026 · PMID 42303108

OBJECTIVE: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D) and a marker of delayed diagnosis, associated with significant morbidity, mortality, and healthcare costs. Global estimates of DKA at T1D onset remain inconsistent. METHODS: We conducted a systematic review and meta-analysis, searching PubMed (1996), Web of Science (1966), Embase (1947), and Scopus (1980), each from its inception to October 2025, without restrictions. Studies reporting DKA prevalence at diagnosis in i…

Rank108.8
Systematic review or meta-analysis

Global distribution of fungal rhinosinusitis.

Rhinology · 2026 · PMID 41785015

BACKGROUND: Fungal rhinosinusitis (FRS) comprises subtypes with varying epidemiology and outcomes. Global comparative data remain limited. METHODS: Following PRISMA guidelines (CRD42023481670), a systematic review and meta-analysis was conducted. Cases were categorized into seven subtypes to assess variation across regions. RESULTS: 2,031 studies (40,860 cases, 77 countries) were included. Non-invasive forms accounted for 60% (n=24,582) of cases, mainly fungal ball (35%, n=14,280) and allergic FRS (25%, n=10,302). …

Rank108.0
Systematic review or meta-analysis

Increased Insulin Resistance and Hyperglycaemia in Long COVID: A Systematic Review and Meta-Analysis.

Expert reviews in molecular medicine · 2026 · PMID 42410961

BACKGROUND: Accumulating evidence suggests that long COVID (LC) is mediated by chronic immune activation, oxidative stress and metabolic dysregulation. These processes may impair glucose homeostasis and promote insulin resistance (IR). However, no prior meta-analysis has systematically and quantitatively evaluated IR indices and related biomarkers in LC compared with normal controls. OBJECTIVES: To systematically review and meta-analyse IR indices including HOMA-IR, HOMA-%B, HOMA-%S, insulin, fasting and random blo…

Rank102.0
Systematic review or meta-analysis

Impact of COVID-19 on the Development of Femoral Head Avascular Necrosis: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42506341

BACKGROUND: COVID-19 has been linked to musculoskeletal complications, including femoral head avascular necrosis (AVN). Both COVID-19-related hypercoagulability and corticosteroid therapy have been proposed as contributing factors. This systematic review synthesizes current evidence on the occurrence, clinical characteristics, timing, and risk factors for femoral head AVN following COVID-19. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, and Scopus identified observational studies and case series …

Rank100.0
Systematic review or meta-analysis

The use of patient-reported outcome questionnaires in patients with post-COVID-19 condition: a systematic review and meta-analysis.

Family practice · 2026 · PMID 42536797

BACKGROUND AND OBJECTIVE: Post-COVID-19 condition (PCC) is a complication of acute COVID-19, which often presents with a variety of symptoms. It can also impact individuals' overall well-being, capacity to carry out daily activities, engage in physical exercise, maintain employment, and their general quality of life. Therefore, this review aimed to examine the role of patient-reported outcome measures (PROMs) questionnaires in assessing patients with PCC through prevalence of abnormal tests. METHODS: We searched th…

Rank100.0
Systematic review or meta-analysis

SPECT/CT Scan Images to Evaluate COVID-19 Pulmonary Complications: A Systematic Review.

International journal of environmental research and public health · 2025 · PMID 40003533

INTRODUCTION: The highly contagious 2019 novel coronavirus that causes coronavirus disease 2019 increased the scientific community's interest in diagnosing and monitoring COVID-19. Due to the findings about the association between COVID-19 infection and pulmonary disturbances, the need for the use of complementary tests that can be carried out, preserving the health of patients, has grown. In this context, single-photon emission computed tomography (SPECT) was performed during the COVID-19 pandemic to assess and tr…

Rank100.0
Systematic review or meta-analysis

Responsible artificial intelligence in medical imaging: a systematic review.

Frontiers in digital health · 2026 · PMID 42535035

INTRODUCTION: Responsible artificial intelligence (AI) in medical imaging requires more than high diagnostic accuracy; it also requires transparent reasoning, equitable performance across patient subgroups, privacy protection, calibrated uncertainty, and clinical trustworthiness. METHODS: This PRISMA-informed systematic review synthesized 24 studies published between 2020 and 2025 that used AI or deep learning for disease detection or diagnostic support in X-ray, CT, MRI, mammography, ultrasound, dermoscopy, retina…

Rank98.6
Systematic review or meta-analysis

Systematic review of amino acid profiles among COVID-19 patients caused by SARS-CoV-2.

Journal of diabetes and metabolic disorders · 2026 · PMID 42491141

BACKGROUND: Emerging evidence highlights the critical role of amino acid metabolism in the pathogenesis and severity of COVID-19. This review included studies encompassing patients with varying degrees of disease severity, from mild to critical cases. METHODS: A systematic review following PRISMA guidelines was conducted, and study quality was appraised using the Newcastle-Ottawa tools to explore the relationship between amino acid profiles and clinical outcomes in COVID-19 patients. A comprehensive search of PubMe…

Rank98.0
Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

CONTEXT: Advanced care planning (ACP) can reduce hospitalizations, increase quality of life, and align treatment with patient wishes, while lowering healthcare costs. However, healthcare providers' discomfort, lack of training, and patient anxiety may hinder ACP. Furthermore, disparities exist among minority and low-income groups. Growing research highlights the need for standardized definitions and broader implementation, especially post-COVID-19, incorporating digital tools, economic impacts, ethics, and family r…

Rank97.6
Randomized controlled trial

Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Randomized Clinical Trial.

JAMA internal medicine · 2025 · PMID 39804633

IMPORTANCE: The optimal configuration of a smoking cessation intervention in a lung cancer screening (LCS) setting has not yet been established. OBJECTIVE: To evaluate the efficacy of 3 tobacco treatment strategies of increasing integration and intensity in the LCS setting. DESIGN, SETTING, AND PARTICIPANTS: In this randomized clinical trial, LCS-eligible current smokers were randomized into 3 treatments: quitline (QL), QL plus (QL+), or integrated care (IC). The study was conducted from July 2017 to June 2022 at a…

Rank95.0
Randomized controlled trial

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings.

Frontiers in immunology · 2024 · PMID 39906744

BACKGROUND: Cytokine release triggered by a hyperactive immune response is thought to contribute to severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2)-related respiratory failure. Bruton tyrosine kinase (BTK) is involved in innate immunity, and BTK inhibitors block cytokine release. We assessed the next-generation BTK inhibitor zanubrutinib in SARS-CoV-2-infected patients with respiratory distress. METHOD: Cohort 1 had a prospective, randomized, double-blind, placebo-controlled design; cohort 2 had a s…

Rank92.0
Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 · PMID 42420160

OBJECTIVES: The PRIME randomized trial demonstrated improved neonatal outcomes using biomarker-guided risk stratification to target interventions to pregnancies at higher risk of preterm birth (PTB). This subgroup analysis evaluated its effectiveness in nulliparous pregnancies, a population with higher baseline risk and limited obstetric history to inform risk assessment. METHODS: PRIME (NCT04301518) was a 19‑center randomized controlled trial evaluating a screen‑guided care strategy using the IGFBP4/SHBG biomarker…

Rank91.8
Randomized clinical study

Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury.

American journal of respiratory and critical care medicine · 2026 · PMID 42150114

RATIONALE: Inflammation in acute respiratory distress syndrome (ARDS) and COVID-19 causes disruption of the alveolar-capillary barrier and tissue damage, which has been associated with increased mortality. Elevated pro-inflammatory plasma biomarker (specifically IL-6) levels reflect the degree of systemic inflammation and are linked to severity of lung injury. Understanding the causal pathway between inflammation, interventions, and patient outcomes could improve clinical care. OBJECTIVES: To assess IL-6 as a media…

Rank86.8
Randomized clinical study

Protocol for an attention-matched randomized controlled trial of 2GETHER: a relationship education and HIV prevention program for young male couples.

Trials · 2022 · PMID 35725624

BACKGROUND: Young men who have sex with men (YMSM) are disproportionately impacted by the HIV epidemic in the USA, and a large number of new infections among YMSM occur in the context of main or primary partnerships. At the same time, healthy romantic relationships promote health and wellbeing by improving social support and encouraging healthy behaviors. Thus, we created 2GETHER: a relationship education and HIV prevention program for young male couples. 2GETHER is delivered face-to-face in a university setting an…

Rank85.0
Randomized clinical study

Diagnostic and clinical management of non-obstructive myocardial ischemia in patients with long Covid-19 syndrome and new-onset chest pain: Design and rationale of the long Covid-19 INOCA trial.

Cardiovascular revascularization medicine : including molecular interventions · 2026 · PMID 42538180

BACKGROUND: Beyond the respiratory symptoms of acute Infection from the SARS-CoV-2 virus, there is evidence that infection with the SARS-CoV-2 virus can cause many significant long-term effects, which are currently termed "Long Covid-19 syndrome (LCS)". Chest pain is one of the dominant symptoms of LCS. The exact mechanism of chest pain in LCS is not fully understood but can be potentially related to endothelial and myocardial cell injury caused by SARS-CoV-2 infection. METHODS: The Long Covid-19 INOCA trial is an …

Rank78.9
Multicenter clinical study

Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality.

JCI insight · 2025 · PMID 41212055

BACKGROUNDAccurate prognostic assays for COVID-19 represent an unmet clinical need. We sought to identify and validate early parsimonious transcriptomic signatures that accurately predict fatal outcomes.METHODSWe studied 894 patients enrolled in the prospective, multicenter Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) with peripheral blood mononuclear cells (PBMC) and nasal swabs collected within 48 hours of admission. Host gene expression was measured with RNA-Seq. We trained parsimonious prognostic …

Rank78.1
Multicenter clinical study

Clinical characteristics and outcomes of SARS-CoV-2-associated stroke: a large multicenter national cohort study.

Einstein (Sao Paulo, Brazil) · 2026 · PMID 42524926

OBJECTIVE: This study aimed to characterize the clinical, laboratory, and neuroimaging profiles of hospitalized Brazilian patients with confirmed SARS-CoV-2 and acute cerebrovascular events. METHODS: This retrospective multicenter study included 374 patients from 17 stroke centers between March and November 2020. Eligible events were ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and cerebral venous thrombosis. The stroke subtypes were further classified using the TOAST, Oxfordshire, and SMASH-…

Rank68.7
Prospective cohort study

Post-COVID-19 Thyroid Dysfunction and Autoimmune Ultrasound Changes: A 12-Month Prospective Cohort Study.

Medicina (Kaunas, Lithuania) · 2026 · PMID 42512896

Background and Objectives: Thyroid dysfunction has been increasingly reported during and after SARS-CoV-2 infection, yet prospective longitudinal studies integrating biochemical and imaging assessments remain limited. The aim of this study was to evaluate the evolution of thyroid function and structural changes during a 12-month follow-up after COVID-19 hospitalization. Materials and Methods: This prospective single-center cohort study included adult patients hospitalized with laboratory-confirmed COVID-19 between …

Rank65.0
Prospective cohort study

Early inflammatory profiling identifies patients at risk for persistent pulmonary dysfunction after COVID-19: a cohort study.

Heart & lung : the journal of critical care · 2026 · PMID 42537340

BACKGROUND: The lack of robust evidence regarding long-term pulmonary outcomes after COVID-19 hampers the development of effective, evidence-based follow-up strategies for affected patients. OBJECTIVE: To prospectively identify patients at risk of persistent pulmonary impairment after COVID-19 based on clinical and inflammatory profiles, aiming to support individualized follow-up strategies and precision medicine approaches. METHODS: In this prospective cohort study, adults hospitalized with COVID-19 underwent infl…

Rank64.8
Observational or cohort study

Increased incidence of mild cognitive impairment in long COVID patients.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 · PMID 41772376

INTRODUCTION: Though brain fog is common in Long-coronavirus disease 2019 (Long-COVID), the incidence of mild cognitive impairment (MCI) is unknown. METHODS: In an observational cohort study, recovered COVID-positive, Long-COVID, and COVID-negative subjects underwent blinded evaluation using National Alzheimer's Coordinating Center (NACC) and National Institute on Aging (NIA) -Alzheimer's Association diagnostic criteria for dementia and MCI. The cumulative incidence of MCI was calculated for each group, and the haz…

Rank64.7
Observational or cohort study

Five years-real-world experience with FilmArray Pneumonia Plus Panel in the diagnosis of pneumonia in an intensive care unit in a tertiary hospital: Lights and shadows in pandemic and postpandemic COVID periods.

Enfermedades infecciosas y microbiologia clinica (English ed.) · 2026 · PMID 42542349

INTRODUCTION: The main objective of the study is to evaluate the performance of the FilmArray® Pneumonia Plus (FA-PP) panel in critically ill patients with suspected pneumonia compared to conventional culture, in both pandemic and pospandemic periods, and its impact on therapeutic decision-making. METHODS: Observational study including 225 patients (314 samples) during COVID-19 pandemic and post-pandemic periods. FA-PP and culture results were compared assessing sensitivity (Se), specificity, predictive values, lev…

Rank62.5
Observational or cohort studyCorrection flagged

Artificial intelligence-enhanced nurse navigation for monitoring and care of long COVID.

International journal of medical informatics · 2026 · PMID 42364466

INTRODUCTION: Long COVID is a multisystem condition with challenging diagnosis. Nurse-navigation, a patient-centered intervention, can enhance education and care access. Analyzing patient-nurse text message exchanges using natural language processing (NLP) enables automated extraction of clinical information, potentially supporting early identification of long COVID. We aimed to evaluate a digital nurse navigation platform integrating a predictive model for long COVID identification as a triage-assisting tool and t…

Rank59.5
Observational or cohort study

Large Vessel Occlusions By Free Floating Thrombi in Strokes During the COVID-19 pandemic- A Single Center Observational Study.

Neurology India · 2022 · PMID 35532630

BACKGROUND: An increased incidence of systemic macrothrombotic phenomena such as strokes has been observed in moderate and severe COVID. However, strokes have also been increasingly observed in mild COVID, post COVID, or without obvious COVID illness. OBJECTIVE: To share our experience with a specific stroke type noted during the COVID pandemic period. MATERIALS AND METHODS: A single-center observational study was conducted in Western India from January to December 2020, and data regarding stroke patients admitted …

Rank56.2
Other PubMed-indexed publication

Coagulation Studies are Frequently Ordered in Emergency Department Chest Pain Patients and do not Change Emergency Department Management.

The Journal of emergency medicine · 2025 · PMID 40021395

BACKGROUND: Despite research findings, implementation into clinical practice is often delayed. Coagulation panels are still ordered as part of an emergency department (ED) chest pain evaluation, despite multiple studies showing that it is unnecessary and does not change management. OBJECTIVE: Our primary outcome is to determine if the practice of ordering coagulation studies (prothrombin time [PT]/international normalized ratio [INR]) is still occurring in ED chest pain patients. Our secondary outcome is to determi…

Rank55.8
Other PubMed-indexed publication

Generation Scotland - Linking all the records we can.

International journal of population data science · 2026 · PMID 42541045

We started a family-based genetic epidemiology study in 2006-11 which recruited 24,000 adult volunteers from 7000 families across Scotland with consent for follow-up through medical record linkage and re-contact. In 2022-25 we have recruited a further 16,000 volunteers, with consent extended to administrative records, and age range now 12+. Original volunteers completed demographic, health and lifestyle questionnaires, provided biological samples, and underwent detailed clinical assessment. The samples, phenotype a…

Evidence Syntheses70 records
Rank112.0
Systematic review or meta-analysis

Psychological and Cognitive Sequelae of COVID-19: Systematic Review and Meta-Analysis.

Journal of psychiatric and mental health nursing · 2026 · PMID 42101066

INTRODUCTION: COVID-19 pandemic has exacerbated global mental health problems with the development of persistent symptoms. AIM: To conduct a prevalence meta-analysis of persistent psychological and cognitive sequelae of COVID-19 based on cohort studies. METHOD: This study followed PRISMA. Cohort studies that followed individuals for at least 12 weeks post-COVID-19 were included and pediatric studies were excluded. The databases Embase, Lilacs/BVS, PubMed, SciELO and Scopus were searched in November 2023. Meta-analy…

Rank112.0
Clinical guideline or consensus statement

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026 · PMID 41856572

BACKGROUND: This guideline aims to address key clinical questions of long COVID, and to provide evidence-based recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses and general practitioners in community healthcare institutions worldwide. METHODS: The guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinar…

Rank110.0
Systematic review or meta-analysis

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Preventive medicine · 2026 · PMID 42303108

OBJECTIVE: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D) and a marker of delayed diagnosis, associated with significant morbidity, mortality, and healthcare costs. Global estimates of DKA at T1D onset remain inconsistent. METHODS: We conducted a systematic review and meta-analysis, searching PubMed (1996), Web of Science (1966), Embase (1947), and Scopus (1980), each from its inception to October 2025, without restrictions. Studies reporting DKA prevalence at diagnosis in i…

Rank110.0
Systematic review or meta-analysis

Interventions to Enhance COVID-19 Pandemic Health Literacy in Health Professionals: Systematic Review.

JMIR medical education · 2026 · PMID 42430764

BACKGROUND: The COVID-19 pandemic has placed a significant burden on health professionals (HPs). They face higher infection risks due to the nature of their work environment and patient care responsibilities. Their ability to access and apply reliable COVID-19 information affects their own preventive behavior and that of those around them. In this context, health literacy (HL) has become increasingly important. Despite extensive research, information to foster COVID-19-related HL in HPs remains limited. OBJECTIVE: …

Rank110.0
Clinical guideline or consensus statement

Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements.

Blood purification · 2025 · PMID 40929000

Extracorporeal blood purification is a technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration, and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus stat…

Rank110.0
Systematic review or meta-analysis

Association between adherence to 24-hour movement guidelines and anxiety and depression: A systematic review and meta-analysis of observational studies.

Journal of affective disorders · 2026 · PMID 42203050

BACKGROUND: Depression and anxiety constitute a global health crisis, with prevalence increasing by 27.6% during the COVID-19 pandemic. The 24-Hour Movement Guidelines, integrating physical activity, sedentary behavior, and sleep, have been linked to improved mental health, yet no meta-analysis has quantified these associations. METHODS: Following PRISMA guidelines, PubMed, Embase, Cochrane Library, and Web of Science were searched through January 1, 2026. Observational studies examining adherence to the 24-Hour Mo…

Rank108.8
Systematic review or meta-analysis

Global distribution of fungal rhinosinusitis.

Rhinology · 2026 · PMID 41785015

BACKGROUND: Fungal rhinosinusitis (FRS) comprises subtypes with varying epidemiology and outcomes. Global comparative data remain limited. METHODS: Following PRISMA guidelines (CRD42023481670), a systematic review and meta-analysis was conducted. Cases were categorized into seven subtypes to assess variation across regions. RESULTS: 2,031 studies (40,860 cases, 77 countries) were included. Non-invasive forms accounted for 60% (n=24,582) of cases, mainly fungal ball (35%, n=14,280) and allergic FRS (25%, n=10,302). …

Rank108.5
Systematic review or meta-analysisResult signal: null

Pharmacological thromboprophylaxis in hospitalized patients with acute infectious diseases: a meta-analysis.

European journal of clinical pharmacology · 2026 · PMID 42479201

INTRODUCTION: Venous thromboembolism (VTE) may be a significant complication in medical patients, and infectious disease has been highlighted as an additional risk factor. Pharmacological thromboprophylaxis can prevent VTE and is recommended in at-risk populations, but not routinely in patients with infectious diseases. METHODS: We conducted a systematic review and meta-analysis of studies on the effectiveness of pharmacological thromboprophylaxis in patients with acute infections, excluding those involving COVID-1…

Rank108.2
Systematic review or meta-analysis

CT-Assessed Sarcopenia Combined with Laboratory Inflammatory Markers for Outcome Prediction in Critically Ill, Pulmonary, and Geriatric Patients: A Systematic Review and Meta-Analysis.

La Clinica terapeutica · 2026 · PMID 42340792

BACKGROUND: Sarcopenia, assessed via computed tomography (CT), is an emerging prognostic tool in critically ill, pulmonary, and geriatric patients. Laboratory inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and neutrophil-to-lymphocyte ratio (NLR) are routinely obtained in these populations. Whether CT-assessed sarcopenia combined with laboratory markers offers superior prognostic accuracy over either measure alone remains unclear. OBJECTIVES: To systematically evaluate the prognostic v…

Rank108.0
Systematic review or meta-analysis

Increased Insulin Resistance and Hyperglycaemia in Long COVID: A Systematic Review and Meta-Analysis.

Expert reviews in molecular medicine · 2026 · PMID 42410961

BACKGROUND: Accumulating evidence suggests that long COVID (LC) is mediated by chronic immune activation, oxidative stress and metabolic dysregulation. These processes may impair glucose homeostasis and promote insulin resistance (IR). However, no prior meta-analysis has systematically and quantitatively evaluated IR indices and related biomarkers in LC compared with normal controls. OBJECTIVES: To systematically review and meta-analyse IR indices including HOMA-IR, HOMA-%B, HOMA-%S, insulin, fasting and random blo…

Rank107.3
Systematic review or meta-analysisResult signal: null

Low-dose corticosteroids in severe pulmonary infection: a meta-analysis of randomised controlled trials.

BMJ open respiratory research · 2026 · PMID 42425738

PURPOSE: Pulmonary infections are one of the leading causes of intensive care unit (ICU) admission and contribute to high mortality rates. This paper aimed to determine the effect of low-dose corticosteroids on outcomes in patients with severe pulmonary infections, including coronavirus disease of 2019, community-acquired pneumonia (CAP), pneumocystis pneumonia, sepsis, septic shock, and acute respiratory distress syndrome. METHODS: We systematically reviewed randomised controlled trials (RCTs) comparing low-dose c…

Rank106.7
Systematic review or meta-analysis

Unveiling the genitourinary phenotype of long COVID: a systematic review and meta-analysis.

International urology and nephrology · 2026 · PMID 41796425

IMPORTANCE: Long COVID has been associated with persistent multisystemic manifestations. However, genitourinary alterations have not been formally recognized as a distinct phenotype despite growing reports suggesting their relevance for long-term morbidity and quality of life. OBJECTIVES: To determine the frequency and characteristics of genitourinary manifestations in patients with long COVID and to evaluate the evidence supporting the possible emergence of a genitourinary phenotype within long COVID. DATA SOURCES…

Rank106.7
Systematic review or meta-analysis

Respiratory Support in the Emergency Department: An Updated Systematic Review and Meta-Analysis.

Worldviews on evidence-based nursing · 2026 · PMID 42410869

BACKGROUND: An estimated 20% of emergency department (ED) patients require respiratory support (RS). Evidence suggests that nasal high flow (NHF) reduces RS need. AIMS: This is an update of a published review comparing NHF to non-invasive ventilation (NIV) or to conventional oxygen therapy (COT) in adult ED patients. METHOD: This updated systematic review (SR) and meta-analysis (MA) methods reflect the Cochrane Collaboration's methodology. The search of six databases was first completed in July 2023 and then repeat…

Rank106.6
Systematic review or meta-analysisResult signal: null

The effect of high-dose of vitamin C on mortality among aged patients with severe COVID-19: A systematic review and meta-analysis.

Clinical and investigative medicine. Medecine clinique et experimentale · 2026 · PMID 42446912

BACKGROUND: Critically ill patients are frequently deficient in vitamin C. Given the significant mortality rates in the elderly population associated with COVID-19, we aimed to systematically review the literature and evaluate whether high-dose vitamin C can reduce COVID-19 mortality in this population. METHODS: Multiple data sources (PubMed, Web of Science, ScienceDirect, and medRxiv) were searched using the keywords "COVID-19" AND "vitamin C" up to November 2024. Randomized controlled trials (RCTs) involving COVI…

Rank106.6
Systematic review or meta-analysisResult signal: benefit

Effect of glucocorticoids on smell sensation in patients with non-traumatic olfactory disorders: a systematic review and meta-analysis.

European journal of clinical pharmacology · 2026 · PMID 42507165

BACKGROUND: The efficacy of glucocorticoids (GCs) for treating non-traumatic olfactory disorders (ODs) remains controversial, with existing meta-analyses showing inconsistent results, largely due to variations in included studies and a lack of etiology-specific analysis. METHODS: This systematic review and meta-analysis followed a pre-registered protocol (PROSPERO: CRD42022319449). We searched four databases up to December 2025 for studies assessing GCs therapy in adults with non-traumatic ODs. Efficacy was analyze…

Rank106.4
Systematic review or meta-analysis

Effect of low-dose naltrexone for long COVID: a systematic review and meta-analysis.

BMJ open · 2026 · PMID 42463201

OBJECTIVE: Long covid is a debilitating chronic condition, and the effect of low-dose naltrexone (LDN) on its symptoms is unclear. We aimed to determine the effectiveness of LDN on symptoms of long covid. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase and Cochrane Library for published studies; ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) for registered ongoing studies were searched through 5 May 2026. ELIGIBILITY CRITERIA: We included randomised cont…

Rank104.1
Systematic review or meta-analysis

Mapping global inequities in telemedicine implementation: An umbrella review of barriers and facilitators.

PloS one · 2026 · PMID 42441648

Telemedicine expanded rapidly during the COVID-19 pandemic, yet its diffusion has remained uneven across health systems. Whether implementation challenges differ systematically across economic contexts, and what implications these differences hold for global digital health equity, has not been comprehensively characterized. This study presents an umbrella review (PROSPERO CRD42024615998) of systematic reviews and meta-analyses indexed in PubMed and Scopus through December 2025 that reported barriers and/or facilita…

Rank103.6
Systematic review or meta-analysis

Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients.

Journal of the American College of Cardiology · 2026 · PMID 42523015

BACKGROUND: Public health emergencies require rapid generation, synthesis, and translation of clinical evidence into practice guidelines; yet, systematic synthesis of the challenges and lessons from these processes remains limited. OBJECTIVES: The purpose of this study was to examine how evidence on anticoagulation in COVID-19 was generated and translated into clinical guidance, using randomized controlled trials (RCTs) as a case study, and to contextualize these processes with an individual participant data meta-a…

Rank103.0
Systematic review or meta-analysis

Quality and methodological heterogeneity of COVID-19 vaccine safety studies focusing on the myocarditis safety signal: A systematic review, meta-analysis and meta-regression.

Vaccine · 2026 · PMID 42142525

BACKGROUND: The risk of myocarditis following COVID-19 vaccines has been widely investigated, yielding highly variable effect estimates. It remains unclear how much of this variation can be explained by methodological differences and study quality. This study aimed to evaluate the methodology of observational studies on myocarditis risk post-COVID-19 vaccination and identify sources of heterogeneity. METHODS: We systematically searched PubMed and EMBASE for observational studies reporting relative risks of myocardi…

Rank102.6
Systematic review or meta-analysis

Evaluation of nirmatrelvir/ritonavir treatment for COVID-19 on health-related outcomes: a global economic value systematic literature review.

Journal of medical economics · 2026 · PMID 42406565

AIMS: Nirmatrelvir/ritonavir (NMV/r)i is an antiviral drug indicated for the treatment of patients with mild to moderate coronavirus disease 2019 (COVID-19) who are at high risk of progressing to severe disease. We performed an updated economic systematic literature review (eSLR) of NMV/r to build upon evidence reported in our previous eSLR and additionally examine the health-related outcomes associated with NMV/r and any potential effect of long COVID. METHODS: A systematic search of Embase, PubMed, Cochrane, and …

Rank102.6
Systematic review or meta-analysis

Effect of Pentoxifylline on Inflammatory Markers in COVID-19: A Meta-Analysis of Randomized Controlled Trials.

Viral immunology · 2026 · PMID 42159324

The hyperinflammatory response in COVID-19 is a major factor contributing to morbidity. Pentoxifylline, a methylxanthine derivative, has immunomodulatory properties, but its effects on inflammatory markers in COVID-19 remain unclear. This meta-analysis aims to evaluate the efficacy of pentoxifylline supplementation on CRP and interleukin-6 (IL-6) levels in these patients. A systematic search was conducted across multiple databases for randomized controlled trials (RCTs) published up to September 2025. Four RCTs, in…

Rank102.0
Systematic review or meta-analysis

Impact of COVID-19 on the Development of Femoral Head Avascular Necrosis: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42506341

BACKGROUND: COVID-19 has been linked to musculoskeletal complications, including femoral head avascular necrosis (AVN). Both COVID-19-related hypercoagulability and corticosteroid therapy have been proposed as contributing factors. This systematic review synthesizes current evidence on the occurrence, clinical characteristics, timing, and risk factors for femoral head AVN following COVID-19. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, and Scopus identified observational studies and case series …

Rank101.9
Systematic review or meta-analysis

Factors associated with occupational fatigue among healthcare workers in Malaysia: a systematic review.

BMJ open · 2026 · PMID 42398993

BACKGROUND: Due to the nature of their work, occupational fatigue is an important issue among healthcare workers (HCWs), with implications for workers' health, patient safety and healthcare organisation performance. However, the evidence on factors of work fatigue among HCWs in Malaysia remains fragmented. OBJECTIVE: To synthesise the existing evidence on work fatigue among HCWs in Malaysia, with a focus on its associated factors across HCW populations and to examine the types of fatigue instruments used. DESIGN: S…

Rank100.0
Systematic review or meta-analysis

Approaches to observational study designs and analytical options to evaluate the safety of multi-dose vaccines: a systematic review.

Expert review of vaccines · 2026 · PMID 42057741

INTRODUCTION: Observational studies require careful considerations when evaluating the safety of multidose vaccines. We reviewed design and analytical approaches in observational studies evaluating the safety of multidose vaccines in the post-licensure phase. METHODS: EMBASE, MEDLINE, Web of Science, and Scopus (2018-2022) were searched for hypothesis-testing studies evaluating the safety of multidose vaccines. Key features from frequently used designs were extracted. RESULTS: Among 123 eligible studies, cohort (46…

Rank100.0
Systematic review or meta-analysisResult signal: harm

Co-managing the double burden: strategies for simultaneously tackling infectious and non-communicable diseases.

Infectious diseases of poverty · 2026 · PMID 42538553

BACKGROUND: Evidence increasingly shows close, bidirectional links between infectious diseases (IDs) and non-communicable diseases (NCDs). However, research, health policy, and prevention practices still largely address them in separate frameworks. This scoping review summarises the current evidence on the interconnections between IDs and NCDs and explores integrated strategies for their prevention and management. METHODS: This scoping review systematically searched PubMed, Web of Science, and Scopus for English-la…

Landmark Evidence82 records
Rank110.0
Clinical guideline or consensus statement

Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements.

Blood purification · 2025 · PMID 40929000

Extracorporeal blood purification is a technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration, and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus stat…

Rank108.8
Systematic review or meta-analysis

Global distribution of fungal rhinosinusitis.

Rhinology · 2026 · PMID 41785015

BACKGROUND: Fungal rhinosinusitis (FRS) comprises subtypes with varying epidemiology and outcomes. Global comparative data remain limited. METHODS: Following PRISMA guidelines (CRD42023481670), a systematic review and meta-analysis was conducted. Cases were categorized into seven subtypes to assess variation across regions. RESULTS: 2,031 studies (40,860 cases, 77 countries) were included. Non-invasive forms accounted for 60% (n=24,582) of cases, mainly fungal ball (35%, n=14,280) and allergic FRS (25%, n=10,302). …

Rank108.6
Systematic review or meta-analysis

Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis.

Reviews in medical virology · 2026 · PMID 42536815

The efficacy of convalescent plasma (CP) in COVID-19 has been contested, with large randomized trials producing conflicting results that led to recommendations against routine use. We performed a systematic review with design-stratified narrative synthesis (PRISMA 2020; SWiM; OSF: https://osf.io/tjcuq) to test whether these conflicting outcomes can be reconciled through three interacting determinants-timing, antibody titre, and host characteristics-using a standardized 91-field extraction matrix applied to each stu…

Rank108.0
Systematic review or meta-analysis

Increased Insulin Resistance and Hyperglycaemia in Long COVID: A Systematic Review and Meta-Analysis.

Expert reviews in molecular medicine · 2026 · PMID 42410961

BACKGROUND: Accumulating evidence suggests that long COVID (LC) is mediated by chronic immune activation, oxidative stress and metabolic dysregulation. These processes may impair glucose homeostasis and promote insulin resistance (IR). However, no prior meta-analysis has systematically and quantitatively evaluated IR indices and related biomarkers in LC compared with normal controls. OBJECTIVES: To systematically review and meta-analyse IR indices including HOMA-IR, HOMA-%B, HOMA-%S, insulin, fasting and random blo…

Rank107.9
Systematic review or meta-analysis

Persistent symptoms among post-COVID-19 survivors: A systematic review and meta-analysis.

Journal of clinical nursing · 2024 · PMID 36426658

BACKGROUND: Single studies support the presence of several post-COVID-19 symptoms; however, there is no evidence for the synthesis of symptoms. OBJECTIVE: We attempt to provide an overview of the persistent symptoms that post-COVID-19 patients encounter, as well as the duration of these symptoms to help them plan their rehabilitation. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: A total of 16 studies involving 8756 patients post-COVID-19 were included. METHODS: The CINAHL, PubMed, EMBASE, Scopus, and …

Rank107.0
Systematic review or meta-analysis

COVID-19 and healthcare workers: A systematic review and meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021 · PMID 33444754

BACKGROUND: The COVID-19 pandemic has focused attention on the challenges and risks faced by frontline healthcare workers (HCW). This study aimed to describe the clinical outcomes and risk factors for SARS-CoV-2 infection in HCW. METHODS: Three databases were surveyed and 328 articles were identified. Of these, 225 articles did not meet inclusion criteria; therefore, 97 full-text article were reviewed. Finally, after further revision, 30 articles were included in the systematic review and 28 were used for meta-anal…

Rank105.9
Systematic review or meta-analysis

Ischemic stroke associated with COVID-19: a systematic review and meta-analysis.

Journal of neurology · 2022 · PMID 34652503

BACKGROUND: Coronavirus disease 2019 (COVID-19), a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. Apart from respiratory complications, an increasing number of patients with ischemic stroke have been reporting. OBJECTIVE: This systematic review and meta-analysis aims to explore the characteristics of ischemic stroke after SARS-CoV-2 infection, and provides valuable reference materials for subsequent clinical treatment. MATERIALS AND…

Rank105.5
Systematic review or meta-analysis

Endometriosis and COVID-19: A Systematic Review and Meta-Analysis.

International journal of molecular sciences · 2022 · PMID 36361745

Endometriosis is defined as ectopic endometrial tissues dispersed outside the endometrium. This can cause disruption in hormonal and immunological processes, which may increase susceptibility to SARS-CoV-2 infection. Worsening of endometriosis symptoms may occur as a result of this infection. The aim of our review was to estimate the pooled prevalence of SARS-CoV-2 infection and the health impacts of the COVID-19 pandemic in endometriosis patients. We conducted a systematic review and meta-analysis. MEDLINE, Scienc…

Rank104.5
Systematic review or meta-analysis

A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat SARS-CoV-2 in Hospitalized Patients: Have the Guidelines Evolved With the Evidence?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40067859

BACKGROUND: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir, a broad-spectrum antiviral. Given the evolving nature of coronavirus disease 2019, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review with meta-analysis to summarize the effectiveness of remdesivir among hospitalize…

Rank104.4
Systematic review or meta-analysis

Long-term impact of SARS-CoV-2 infection on cardiorespiratory fitness: a meta-analysis.

Frontiers in public health · 2023 · PMID 37920575

BACKGROUND: Despite surviving Coronavirus disease 2019 (COVID-19), its long-term impact is of concern. Low cardiorespiratory fitness is a strong predictor of all-cause mortality, and likely affected by multisystem impairments following COVID-19 infection. Accumulating evidence has identified the impact of COVID-19 on cardiorespiratory fitness level. However, the findings have been controversial. Conclusive evidence is still needed. OBJECTIVES: This review aimed to systematically summarize and synthesize whether the…

Rank104.2
Systematic review or meta-analysis

Cardiac Complications in COVID-19: A Systematic Review and Meta-analysis.

Archives of Iranian medicine · 2021 · PMID 33636985

BACKGROUND: The newly emerged coronavirus disease 2019 (COVID-19) seems to involve different organs, including the cardiovascular system. We systematically reviewed COVID-19 cardiac complications and calculated their pooled incidences. Secondarily, we compared the cardiac troponin I (cTnI) level between the surviving and expired patients. METHODS: A systematic search was conducted for manuscripts published from December 1, 2019 to April 16, 2020. Cardiovascular complications, along with the levels of cTnI, creatine…

Rank104.0
Systematic review or meta-analysis

Cardiovascular complications of SARS-CoV-2 infection (COVID-19): a systematic review and meta-analysis.

Reviews in cardiovascular medicine · 2021 · PMID 33792257

Coronavirus Disease 2019 (COVID-19) originated in Wuhan, China in December 2019 and rapidly spread worldwide. Herein, we conducted a systematic review and meta-analysis to find the association between COVID-19 and cardiovascular complications. We conducted a systematic literature search of the PubMed and Embase databases from 01 December 2019 to 30 November 2020. We then statistically analyzed the incidence of cardiovascular complications in COVID-19 patients. We included 3044 confirmed COVID-19 cases from 12 studi…

Rank103.6
Systematic review or meta-analysisResult signal: harm

Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis.

Journal of endocrinological investigation · 2022 · PMID 35527294

PURPOSE: The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated. METHODS: All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male …

Rank103.3
Systematic review or meta-analysis

Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.

Reviews in medical virology · 2026 · PMID 42536824

Anti-Spike monoclonal antibodies (mAbs) progressively lost efficacy during the COVID-19 pandemic due to the emergence and predominance of resistant SARS-CoV-2 variants. By contrast, high-titre COVID-19 convalescent plasma (CCP) collected from vaccinated donors recently recovered from infection provides a polyclonal source of antibodies that remains effective in clearing SARS-CoV-2 in immunosuppressed patients, unable to mount an adequate immune response against the virus. We conducted a systematic review and indivi…

Rank103.3
Systematic review or meta-analysis

Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis.

Cardiology journal · 2021 · PMID 33942278

BACKGROUND: The purpose herein, was to perform a systematic review of interventional outcome studies in patients with in-hospital cardiac arrest before and during the coronavirus disease 2019 (COVID-19) pandemic period. METHODS: A meta-analysis was performed of publications meeting the following PICOS criteria: (1) participants, patients > 18 years of age with cardiac arrest due to any causes; (2) intervention, cardiac arrest in COVID-19 period; (3) comparison, cardiac arrest in pre-COVID-19 period; (4) outcomes, d…

Rank103.0
Systematic review or meta-analysis

Obesity in COVID-19: A Systematic Review and Meta-analysis.

Annals of the Academy of Medicine, Singapore · 2020 · PMID 33463658

OBJECTIVE: Obesity has been shown to be associated with adverse outcomes in viral infections such as influenza, but previous studies on coronavirus disease 2019 (COVID-19) had mixed results. The aim of this systematic review is to investigate the relationship between COVID-19 and obesity. METHODS: We performed a systematic review and meta-analysis. A literature search of MEDLINE, EMBASE, Scopus, Web of Science, CENTRAL, OpenGrey and preprint servers medRxiv and bioRxiv was performed, with no restriction on language…

Rank103.0
Systematic review or meta-analysis

Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe outcomes in adults: a systematic review and meta-analysis of European studies published up to 22 January 2024.

European respiratory review : an official journal of the European Respiratory Society · 2025 · PMID 39971395

BACKGROUND: Up-to-date evidence from European studies on long-term vaccine effectiveness (VE) of COVID-19 vaccines is lacking. This review aimed to evaluate effectiveness and durability of primary vaccine series and boosters in preventing infection and severe outcomes in the European population. METHODS: We conducted systematic searches of PubMed and Embase up to 22 January 2024. We included observational studies that evaluated VE against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or sev…

Rank102.6
Systematic review or meta-analysisResult signal: harm

COVID-19 associated oral and oropharyngeal microbiome: Systematic review and meta-analysis.

Periodontology 2000 · 2024 · PMID 37277934

Three years into the coronavirus disease 2019 (COVID-19) pandemic, there are still growing concerns with the emergence of different variants, unknown long- and short-term effects of the virus, and potential biological mechanisms underlying etiopathogenesis and increased risk for morbidity and mortality. The role of the microbiome in human physiology and the initiation and progression of several oral and systemic diseases have been actively studied in the past decade. With the proof of viral transmission, carriage, …

Rank102.6
Systematic review or meta-analysis

Differences of the Chest Images Between Coronavirus Disease 2019 (COVID-19) Patients and Influenza Patients: A Systematic Review and Meta-analysis.

International journal of medical sciences · 2025 · PMID 39898255

Background: Coronavirus disease 2019 (COVID-19) and influenza are two infectious diseases that can pose a great threat to human health. We aimed to compare the differences in chest images between patients with COVID-19 and influenza to deepen the understanding of these two diseases. Methods: We searched PubMed, Embase and Web of Science for articles published before December 25, 2023, and performed a meta-analysis using Stata 14.0 with a random-effects model. The study was conducted in accordance with the Preferred…

Rank102.0
Systematic review or meta-analysis

Impact of COVID-19 on the Development of Femoral Head Avascular Necrosis: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42506341

BACKGROUND: COVID-19 has been linked to musculoskeletal complications, including femoral head avascular necrosis (AVN). Both COVID-19-related hypercoagulability and corticosteroid therapy have been proposed as contributing factors. This systematic review synthesizes current evidence on the occurrence, clinical characteristics, timing, and risk factors for femoral head AVN following COVID-19. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, and Scopus identified observational studies and case series …

Rank101.9
Systematic review or meta-analysis

Orofacial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review.

International dental journal · 2022 · PMID 35367044

OBJECTIVES: Studies reviewing orofacial mycoses in coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection are sparse. Here we review the major oral and maxillofacial mycoses of COVID-19, the associated comorbidities, and the probable precipitating factors. METHODS: English-language manuscripts published between March 2020 and October 2021 were searched using PubMed, OVID, SCOPUS, and Web of Science databases, using appropriate keywords. RESULTS: We identified 30 art…

Rank101.4
Systematic review or meta-analysis

Prophylaxis against covid-19: living systematic review and network meta-analysis.

BMJ (Clinical research ed.) · 2021 · PMID 33903131

UPDATES: This is the second version (first update) of the living systematic review, replacing the previous version (available as a data supplement). When citing this paper please consider adding the version number and date of access for clarity. OBJECTIVE: To determine and compare the effects of drug prophylaxis on severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (covid-19). DESIGN: Living systematic review and network meta-analysis (NMA). DATA SOURCES: World…

Rank101.4
Systematic review or meta-analysis

Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta-analysis.

Journal of medical virology · 2021 · PMID 32691881

We aim to systematically review the characteristics of asymptomatic infection in the coronavirus disease 2019 (COVID-19). PubMed and EMBASE were electronically searched to identify original studies containing the rate of asymptomatic infection in COVID-19 patients before 20 May 2020. Then mate-analysis was conducted using R version 3.6.2. A total of 50 155 patients from 41 studies with confirmed COVID-19 were included. The pooled percentage of asymptomatic infection is 15.6% (95% CI, 10.1%-23.0%). Ten included stud…

Rank100.7
Systematic review or meta-analysis

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection.

Diabetes & metabolic syndrome · 2020 · PMID 32771919

BACKGROUND AND AIMS: The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing. The identification of risk factors for severe outcomes is important. Dyslipidemia has been shown as a long-known risk factor for cardiovascular disease. The aim of this study is to analyze the potential association between dyslipidemia and the severity of COVID-19 infection. METHODS: We systematically searched the PubMed database using specific keywords related to our aims until July 9th, 2020. …

Rank100.6
Systematic review or meta-analysis

A systematic review and meta-analysis of the COVID-19 associated liver injury.

Annals of hepatology · 2020 · PMID 32882393

INTRODUCTION AND OBJECTIVES: The novel coronavirus disease 2019 (COVID-19) has affected more than 5 million people globally. Data on the prevalence and degree of COVID-19 associated liver injury among patients with COVID-19 remain limited. We conducted a systematic review and meta-analysis to assess the prevalence and degree of liver injury between patients with severe and non-severe COVID-19. METHODS: We performed a systematic search of three electronic databases (PubMed/MEDLINE, EMBASE and Cochrane Library), from…

Most Effective Evidence Supported Treatments69 records
Rank112.0
Clinical guideline or consensus statement

Clinical practice guideline for long COVID prevention and treatment.

The European respiratory journal · 2026 · PMID 41856572

BACKGROUND: This guideline aims to address key clinical questions of long COVID, and to provide evidence-based recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses and general practitioners in community healthcare institutions worldwide. METHODS: The guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinar…

Rank110.0
Clinical guideline or consensus statement

Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements.

Blood purification · 2025 · PMID 40929000

Extracorporeal blood purification is a technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration, and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus stat…

Rank108.5
Systematic review or meta-analysisResult signal: null

Pharmacological thromboprophylaxis in hospitalized patients with acute infectious diseases: a meta-analysis.

European journal of clinical pharmacology · 2026 · PMID 42479201

INTRODUCTION: Venous thromboembolism (VTE) may be a significant complication in medical patients, and infectious disease has been highlighted as an additional risk factor. Pharmacological thromboprophylaxis can prevent VTE and is recommended in at-risk populations, but not routinely in patients with infectious diseases. METHODS: We conducted a systematic review and meta-analysis of studies on the effectiveness of pharmacological thromboprophylaxis in patients with acute infections, excluding those involving COVID-1…

Rank107.3
Systematic review or meta-analysisResult signal: null

Low-dose corticosteroids in severe pulmonary infection: a meta-analysis of randomised controlled trials.

BMJ open respiratory research · 2026 · PMID 42425738

PURPOSE: Pulmonary infections are one of the leading causes of intensive care unit (ICU) admission and contribute to high mortality rates. This paper aimed to determine the effect of low-dose corticosteroids on outcomes in patients with severe pulmonary infections, including coronavirus disease of 2019, community-acquired pneumonia (CAP), pneumocystis pneumonia, sepsis, septic shock, and acute respiratory distress syndrome. METHODS: We systematically reviewed randomised controlled trials (RCTs) comparing low-dose c…

Rank106.6
Systematic review or meta-analysisResult signal: benefit

Effect of glucocorticoids on smell sensation in patients with non-traumatic olfactory disorders: a systematic review and meta-analysis.

European journal of clinical pharmacology · 2026 · PMID 42507165

BACKGROUND: The efficacy of glucocorticoids (GCs) for treating non-traumatic olfactory disorders (ODs) remains controversial, with existing meta-analyses showing inconsistent results, largely due to variations in included studies and a lack of etiology-specific analysis. METHODS: This systematic review and meta-analysis followed a pre-registered protocol (PROSPERO: CRD42022319449). We searched four databases up to December 2025 for studies assessing GCs therapy in adults with non-traumatic ODs. Efficacy was analyze…

Rank106.4
Systematic review or meta-analysis

Effect of low-dose naltrexone for long COVID: a systematic review and meta-analysis.

BMJ open · 2026 · PMID 42463201

OBJECTIVE: Long covid is a debilitating chronic condition, and the effect of low-dose naltrexone (LDN) on its symptoms is unclear. We aimed to determine the effectiveness of LDN on symptoms of long covid. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase and Cochrane Library for published studies; ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) for registered ongoing studies were searched through 5 May 2026. ELIGIBILITY CRITERIA: We included randomised cont…

Rank105.0
Systematic review or meta-analysis

Nebulized Heparin in Adults With Acute Respiratory Failure: A Meta-Analysis of Randomized Trials.

Critical care medicine · 2026 · PMID 42148826

OBJECTIVES: Dysregulated pulmonary coagulation and inflammation is a hallmark of respiratory failure in various etiologies. Excessive fibrin deposition contributes to alveolar collapse, impaired gas exchange, and progression to pulmonary fibrosis. Nebulized heparin can mitigate these coagulation and inflammation disturbances. Although several randomized controlled trials have explored its effects, results remain inconsistent and limited by small patient populations. We conducted a random-effects meta-analysis to ca…

Rank102.6
Systematic review or meta-analysis

Effect of Pentoxifylline on Inflammatory Markers in COVID-19: A Meta-Analysis of Randomized Controlled Trials.

Viral immunology · 2026 · PMID 42159324

The hyperinflammatory response in COVID-19 is a major factor contributing to morbidity. Pentoxifylline, a methylxanthine derivative, has immunomodulatory properties, but its effects on inflammatory markers in COVID-19 remain unclear. This meta-analysis aims to evaluate the efficacy of pentoxifylline supplementation on CRP and interleukin-6 (IL-6) levels in these patients. A systematic search was conducted across multiple databases for randomized controlled trials (RCTs) published up to September 2025. Four RCTs, in…

Rank102.6
Systematic review or meta-analysis

Evaluation of nirmatrelvir/ritonavir treatment for COVID-19 on health-related outcomes: a global economic value systematic literature review.

Journal of medical economics · 2026 · PMID 42406565

AIMS: Nirmatrelvir/ritonavir (NMV/r)i is an antiviral drug indicated for the treatment of patients with mild to moderate coronavirus disease 2019 (COVID-19) who are at high risk of progressing to severe disease. We performed an updated economic systematic literature review (eSLR) of NMV/r to build upon evidence reported in our previous eSLR and additionally examine the health-related outcomes associated with NMV/r and any potential effect of long COVID. METHODS: A systematic search of Embase, PubMed, Cochrane, and …

Rank100.0
Systematic review or meta-analysis

Stellate Ganglion Block in the Treatment of Long COVID: A Systematic Review.

Current pain and headache reports · 2026 · PMID 41973314

OBJECTIVES: This review evaluates stellate ganglion block as a treatment for long COVID, seeking to evaluate the treatment's efficacy by various symptoms and the limitations of the current literature. STUDY DESIGN: Systematic Review. SETTING: Ambulatory or Outpatient Setting. METHODS, SUBJECTS: A systematic review of the current literature regarding use of stellate ganglion block in patients with long COVID was conducted. 2 databases were searched on August 28th, 2025. Search terms were "long COVID" and "stellate g…

Rank100.0
Systematic review or meta-analysisResult signal: harm

Co-managing the double burden: strategies for simultaneously tackling infectious and non-communicable diseases.

Infectious diseases of poverty · 2026 · PMID 42538553

BACKGROUND: Evidence increasingly shows close, bidirectional links between infectious diseases (IDs) and non-communicable diseases (NCDs). However, research, health policy, and prevention practices still largely address them in separate frameworks. This scoping review summarises the current evidence on the interconnections between IDs and NCDs and explores integrated strategies for their prevention and management. METHODS: This scoping review systematically searched PubMed, Web of Science, and Scopus for English-la…

Rank100.0
Systematic review or meta-analysis

Patient and provider experiences with opioid use disorder care delivered via telehealth: A systematic mixed-studies review.

Drug and alcohol dependence · 2025 · PMID 39662356

INTRODUCTION: Since the onset of the COVID-19 pandemic and loosening of some opioid use disorder (OUD) treatment regulations in the U.S. and Canada, there has been a rapid rise in the use of telehealth for buprenorphine induction, maintenance, and counseling (tele-bupe). Previous reviews highlight that tele-bupe can expand access to OUD care and improve treatment retention, but none to date have synthesized patient and clinician experiences with and perceptions of this care. OBJECTIVE: This review synthesized findi…

Rank100.0
Systematic review or meta-analysis

The Economic Value of Non-pharmaceutical Interventions for Influenza and COVID-19: A Systematic Review.

Applied health economics and health policy · 2026 · PMID 41882484

BACKGROUND: Non-pharmaceutical interventions (NPIs) are central to mitigating COVID-19 and influenza, yet comparative economic evaluations remain scarce. This systematic review assessed the cost effectiveness and reporting quality of NPI evaluations across both diseases. The study was registered with PROSPERO (CRD42024552613). METHODS: Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, we searched five medical (PubMed, Scopus, EMBASE, CINAHL, and EconLit) and four h…

Rank100.0
Systematic review or meta-analysis

Effect of Yoga Intervention for Health Care Workers During the COVID-19 Pandemic: A Systematic Review.

Journal of integrative and complementary medicine · 2026 · PMID 41782516

BACKGROUND: Health care workers (HCWs) faced unprecedented stress, anxiety, and burnout during the COVID-19 pandemic. Yoga, a mind-body practice combining physical postures, breathing, and meditation, has demonstrated benefits for mental and physical resilience. This systematic review evaluated the effectiveness of yoga interventions in addressing mental health challenges and promoting overall well-being among HCWs during the pandemic. METHODS: This review adhered to Preferred Reporting Items for Systematic Reviews…

Rank100.0
Systematic review or meta-analysis

Experiences of team collaboration among intensive care nurses during COVID-19: a qualitative systematic review and meta-synthesis.

Frontiers in public health · 2026 · PMID 42518594

OBJECTIVE: This study included qualitative studies and employed a meta-synthesis to assess the support, challenges, and coping strategies related to teamwork among Intensive Care Unit (ICU) nurses during the Corona Virus Disease 2019 (COVID-19) pandemic. DESIGN: Qualitative meta-synthesis. METHODS: A systematic search was conducted across five databases: PubMed, Web of Science, Embase, CINAHL, and PsycINFO. The search period covered from inception to December 11, 2025. The study employed the three-stage thematic sy…

Rank99.9
Randomized controlled trial

Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial.

Nature communications · 2026 · PMID 42533000

Persistent cardiac symptoms are common in post-COVID syndrome, even without structural heart disease. Evidence implicates immune dysregulation, endothelial dysfunction and low-grade cardiovascular inflammation. Yet no targeted treatment exists. Myoflame-19 is a multicenter, double-blind clinical trial of 279 participants with inflammatory cardiac involvement defined by cardiovascular magnetic resonance, randomized 1:1 to losartan plus prednisolone (n = 139) or matching placebos (n = 140) for 16 weeks. The modified …

Rank99.5
Randomized controlled trialResult signal: null

Ensitrelvir for the Treatment of Hospitalized Adults With COVID-19: An International Phase 3 Randomized Placebo-controlled Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 42017206

BACKGROUND: Antivirals remain an important treatment strategy for persons who experience severe and life-threatening COVID-19. Ensitrelvir is an oral 3CL protease inhibitor with potent antiviral activity. METHODS: We conducted an international randomized, placebo-controlled trial of ensitrelvir with standard of care (SOC) among adults hospitalized for COVID-19. The primary outcome was clinical recovery assessed by the days to recovery scale through day 60 (DRS-60), analyzed using a Van Elteren test. RESULTS: From 2…

Rank98.9
Randomized controlled trial

Cognitive Rehabilitation and Functional Outcomes in Long COVID-Related Cognitive Impairment: A Randomized Clinical Trial.

JAMA network open · 2026 · PMID 42384384

IMPORTANCE: Cognitive impairment is common in long COVID and severely affects daily life, with no proven treatments to date. OBJECTIVE: To evaluate the ability of cognitive rehabilitation (CR) to improve goal attainment, cognitive, and clinical outcomes in individuals with cognitive impairment as part of long COVID. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, single-blind, 2-arm, parallel-group randomized clinical trial was conducted at 3 sites in England between February 2023 and March 2024. Participants …

Rank98.1
Randomized controlled trial

Effectiveness of the school-based internet intervention StresSOS for the prevention of mental health problems in young people: a randomized controlled trial as part of the ProHEAD consortium.

Journal of child psychology and psychiatry, and allied disciplines · 2026 · PMID 41821499

BACKGROUND: Given the high prevalence of mental illnesses in adolescents, there is an urgent need for effective prevention strategies. The aim of this study was to evaluate the school-based internet intervention StresSOS for the universal prevention of mental illnesses in youth. METHODS: A two-arm, randomized controlled trial was conducted. Participants were recruited from schools across five regions of Germany. Young people between the ages of 12 and 25 years without mental health problems were invited to the tria…

Rank98.1
Randomized controlled trial

Epcoritamab monotherapy or epcoritamab with lenalidomide as first-line therapy for patients with diffuse large B-cell lymphoma (EPCORE DLBCL-3): primary analysis of an open-label, multicentre, randomised, phase 2 trial.

The Lancet. Haematology · 2026 · PMID 42285113

BACKGROUND: Anthracycline-free regimens are needed for older adults with newly diagnosed diffuse large B-cell lymphoma (DLBCL). We aim to evaluate the efficacy and safety of fixed-duration epcoritamab monotherapy versus epcoritamab with lenalidomide in this patient population. METHODS: This open-label, multicentre, randomised, phase 2 trial was conducted at 44 hospitals across 11 countries in Europe and Asia. Patients had newly diagnosed, histologically confirmed CD20-positive large B-cell lymphoma, were ineligible…

Rank98.0
Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

CONTEXT: Advanced care planning (ACP) can reduce hospitalizations, increase quality of life, and align treatment with patient wishes, while lowering healthcare costs. However, healthcare providers' discomfort, lack of training, and patient anxiety may hinder ACP. Furthermore, disparities exist among minority and low-income groups. Growing research highlights the need for standardized definitions and broader implementation, especially post-COVID-19, incorporating digital tools, economic impacts, ethics, and family r…

Rank97.6
Randomized controlled trial

Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Randomized Clinical Trial.

JAMA internal medicine · 2025 · PMID 39804633

IMPORTANCE: The optimal configuration of a smoking cessation intervention in a lung cancer screening (LCS) setting has not yet been established. OBJECTIVE: To evaluate the efficacy of 3 tobacco treatment strategies of increasing integration and intensity in the LCS setting. DESIGN, SETTING, AND PARTICIPANTS: In this randomized clinical trial, LCS-eligible current smokers were randomized into 3 treatments: quitline (QL), QL plus (QL+), or integrated care (IC). The study was conducted from July 2017 to June 2022 at a…

Rank97.6
Randomized controlled trial

PhysiotherApeutic Treat-To-Target Intervention After Total Hip and Knee Arthroplasty Does Not Improve Outcomes Compared to Usual Physical Therapy: The PATIO Study.

The Journal of arthroplasty · 2026 · PMID 41177186

BACKGROUND: This nationwide superiority cluster randomized controlled trial evaluated the effectiveness of a personalized, treat-to-target postoperative physical therapy (PPT) strategy compared to usual care after total hip arthroplasty (THA) and total knee arthroplasty (TKA). METHODS: There were 18 hospitals randomized to treat-to-target or usual PPT, with 624 patients undergoing primary THA or TKA being eligible for participation. Assessments were conducted preoperatively and at six, 12, 24, and 52 weeks after su…

Rank97.2
Randomized controlled trial

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy · 2026 · PMID 42241901

BACKGROUND: During the COVID-19 pandemic, Mesenchymal Stromal Cells (MSCs) were rapidly proposed as a therapeutic option for Acute Respiratory Distress Syndrome (ARDS) based on their immunomodulatory properties. We report the results of COVIDMES, a multicenter trial initiated within a public blood and tissue bank infrastructure during unprecedented period of volatility and scientific uncertainty of the first pandemic waves. AIMS: To evaluate the safety, feasibility and exploratory efficacy of Wharton's Jelly-derive…

Rank97.1
Randomized controlled trial

CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial.

EBioMedicine · 2026 · PMID 42315445

BACKGROUND: APOE ε4 carriers have increased Alzheimer's disease risk and altered omega-3 metabolism. No large-scale prevention trials have tested high-dose docosahexaenoic acid (DHA) supplementation specifically in non-demented APOE ε4 carriers with low baseline omega-3 intake for early intervention. METHODS: We conducted a phase IIa 24-month, randomised, double-blind, placebo-controlled trial (NCT03613844) at the University of Southern California between September 2018 and May 2024. Participants aged 55-80 years w…

New Research Last 24 Months398 records
Rank108.8
Systematic review or meta-analysis

Global distribution of fungal rhinosinusitis.

Rhinology · 2026 · PMID 41785015

BACKGROUND: Fungal rhinosinusitis (FRS) comprises subtypes with varying epidemiology and outcomes. Global comparative data remain limited. METHODS: Following PRISMA guidelines (CRD42023481670), a systematic review and meta-analysis was conducted. Cases were categorized into seven subtypes to assess variation across regions. RESULTS: 2,031 studies (40,860 cases, 77 countries) were included. Non-invasive forms accounted for 60% (n=24,582) of cases, mainly fungal ball (35%, n=14,280) and allergic FRS (25%, n=10,302). …

Rank108.0
Systematic review or meta-analysis

Increased Insulin Resistance and Hyperglycaemia in Long COVID: A Systematic Review and Meta-Analysis.

Expert reviews in molecular medicine · 2026 · PMID 42410961

BACKGROUND: Accumulating evidence suggests that long COVID (LC) is mediated by chronic immune activation, oxidative stress and metabolic dysregulation. These processes may impair glucose homeostasis and promote insulin resistance (IR). However, no prior meta-analysis has systematically and quantitatively evaluated IR indices and related biomarkers in LC compared with normal controls. OBJECTIVES: To systematically review and meta-analyse IR indices including HOMA-IR, HOMA-%B, HOMA-%S, insulin, fasting and random blo…

Rank106.0
Systematic review or meta-analysis

Estimated global prevalence of metabolic syndrome: a proportional meta-analysis.

European journal of cardiovascular nursing · 2026 · PMID 42538574

AIM: Metabolic syndrome is a major global health burden. However, existing global prevalence estimates are largely based on studies conducted before the COVID-19 pandemic and do not fully account for contemporary epidemiological and structural determinants. This systematic review and meta-analysis updated global metabolic syndrome prevalence estimates and examined associated socioeconomic and healthcare system correlates using the most recent available evidence. METHODS AND RESULTS: Six databases were searched from…

Rank102.0
Systematic review or meta-analysis

Impact of COVID-19 on the Development of Femoral Head Avascular Necrosis: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42506341

BACKGROUND: COVID-19 has been linked to musculoskeletal complications, including femoral head avascular necrosis (AVN). Both COVID-19-related hypercoagulability and corticosteroid therapy have been proposed as contributing factors. This systematic review synthesizes current evidence on the occurrence, clinical characteristics, timing, and risk factors for femoral head AVN following COVID-19. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, and Scopus identified observational studies and case series …

Rank100.0
Systematic review or meta-analysis

Impact of Non-Pharmaceutical Interventions Targeted at COVID-19 Pandemic on Influenza Burden-A Systematic Review and Meta-Analysis.

Influenza and other respiratory viruses · 2026 · PMID 42522402

Seasonal influenza imposes a substantial global health burden. The COVID-19 pandemic, accompanied by widespread non-pharmaceutical interventions (NPIs), profoundly disrupted respiratory virus circulation, offering a unique opportunity to assess their broader epidemiological impact. This study aimed to quantify changes in influenza burden between the pre-pandemic and intra-pandemic periods. Within the RESPINOW project, we conducted a systematic review following PRISMA guidelines. Studies reporting absolute influenza…

Rank100.0
Systematic review or meta-analysis

Responsible artificial intelligence in medical imaging: a systematic review.

Frontiers in digital health · 2026 · PMID 42535035

INTRODUCTION: Responsible artificial intelligence (AI) in medical imaging requires more than high diagnostic accuracy; it also requires transparent reasoning, equitable performance across patient subgroups, privacy protection, calibrated uncertainty, and clinical trustworthiness. METHODS: This PRISMA-informed systematic review synthesized 24 studies published between 2020 and 2025 that used AI or deep learning for disease detection or diagnostic support in X-ray, CT, MRI, mammography, ultrasound, dermoscopy, retina…

Rank100.0
Systematic review or meta-analysis

Autoimmunity following SARS-CoV-2 infection and vaccination: Systematic review and meta-analysis.

Clinical immunology (Orlando, Fla.) · 2026 · PMID 41905519

AIM: To systematically review and meta-analyze the available evidence on the association between SARS-CoV-2 infection, COVID-19 vaccination, and the development of new autoimmune conditions (AIC). METHODS: This study followed the PRISMA guidelines. MEDLINE, Scopus, Cochrane Library, and Google Scholar were searched until December 31, 2024, for studies reporting new-onset autoimmunity after SARS-CoV-2 infection or vaccination. Meta-analyses using random-effects models calculated pooled odds ratios using RStudio 4.3.…

Rank100.0
Systematic review or meta-analysis

Stellate Ganglion Block in the Treatment of Long COVID: A Systematic Review.

Current pain and headache reports · 2026 · PMID 41973314

OBJECTIVES: This review evaluates stellate ganglion block as a treatment for long COVID, seeking to evaluate the treatment's efficacy by various symptoms and the limitations of the current literature. STUDY DESIGN: Systematic Review. SETTING: Ambulatory or Outpatient Setting. METHODS, SUBJECTS: A systematic review of the current literature regarding use of stellate ganglion block in patients with long COVID was conducted. 2 databases were searched on August 28th, 2025. Search terms were "long COVID" and "stellate g…

Rank100.0
Systematic review or meta-analysis

The use of patient-reported outcome questionnaires in patients with post-COVID-19 condition: a systematic review and meta-analysis.

Family practice · 2026 · PMID 42536797

BACKGROUND AND OBJECTIVE: Post-COVID-19 condition (PCC) is a complication of acute COVID-19, which often presents with a variety of symptoms. It can also impact individuals' overall well-being, capacity to carry out daily activities, engage in physical exercise, maintain employment, and their general quality of life. Therefore, this review aimed to examine the role of patient-reported outcome measures (PROMs) questionnaires in assessing patients with PCC through prevalence of abnormal tests. METHODS: We searched th…

Rank100.0
Systematic review or meta-analysisResult signal: harm

Co-managing the double burden: strategies for simultaneously tackling infectious and non-communicable diseases.

Infectious diseases of poverty · 2026 · PMID 42538553

BACKGROUND: Evidence increasingly shows close, bidirectional links between infectious diseases (IDs) and non-communicable diseases (NCDs). However, research, health policy, and prevention practices still largely address them in separate frameworks. This scoping review summarises the current evidence on the interconnections between IDs and NCDs and explores integrated strategies for their prevention and management. METHODS: This scoping review systematically searched PubMed, Web of Science, and Scopus for English-la…

Rank98.6
Systematic review or meta-analysis

Systematic review of amino acid profiles among COVID-19 patients caused by SARS-CoV-2.

Journal of diabetes and metabolic disorders · 2026 · PMID 42491141

BACKGROUND: Emerging evidence highlights the critical role of amino acid metabolism in the pathogenesis and severity of COVID-19. This review included studies encompassing patients with varying degrees of disease severity, from mild to critical cases. METHODS: A systematic review following PRISMA guidelines was conducted, and study quality was appraised using the Newcastle-Ottawa tools to explore the relationship between amino acid profiles and clinical outcomes in COVID-19 patients. A comprehensive search of PubMe…

Rank98.1
Systematic review or meta-analysis

Evaluating the Effectiveness of Antivirals for COVID-19 in the Post-vaccine, Omicron Era: A Systematic Review and Meta-analysis.

Open forum infectious diseases · 2026 · PMID 42534418

INTRODUCTION: Randomized controlled trials (RCTs) of oral antivirals for COVID-19 conducted early in the pandemic had favorable results in unvaccinated populations. We conducted a systematic review and meta-analysis of the effectiveness of nirmatrelvir-ritonavir and molnupiravir against hospitalization and death in vaccinated populations in the post-Omicron era. METHODS: We systematically searched PubMed, Embase and the Cochrane library for RCTs conducted from January 2020, and observational studies in adults who w…

Rank98.1
Randomized controlled trial

Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial.

Lancet (London, England) · 2026 · PMID 42442374

BACKGROUND: Latin America faces a high dementia burden, with increased prevalence of factors associated with cognitive decline. Multidomain lifestyle interventions might delay cognitive decline, but populations from Latin America remain under-represented in dementia prevention trials. We aimed to investigate the feasibility of a culturally adapted, multidomain, systematic lifestyle intervention and investigate its effects on global cognitive function in at-risk older adults (aged 60-77 years). METHODS: The LatAm-FI…

Rank97.5
Randomized controlled trial

Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study).

Gut microbes · 2026 · PMID 42520140

BACKGROUND: Although COVID-19 vaccination has reduced morbidity and mortality, adults aged 65 y old and older are at high risk of complications from COVID-19. The evidence suggests that probiotics may enhance immune responses when co-administered with influenza vaccination. However, few studies have evaluated the potential benefit of probiotic supplementation in this context in this high-risk population. MATERIAL: This study was a randomized controlled trial recruiting adults between 65 and 89 y of age living in Qu…

Rank96.0
Systematic review or meta-analysis

Telemedicine in pediatrics: a critical narrative review of innovations, limitations, and future priorities.

European journal of pediatrics · 2026 · PMID 42541600

UNLABELLED: This narrative review synthesizes recent technological and organizational developments in pediatric telemedicine, maps their principal clinical applications, and critically discusses implementation, safety, equity, and future priorities. This narrative review used a transparent, non-systematic literature-search approach in PubMed/MEDLINE, Scopus, and Google Scholar, considering publications available through April 2026. Searches were intended to identify and contextualize relevant literature across pedi…

Rank96.0
Randomized controlled trialResult signal: null

A Randomised Controlled Trial Testing a Behavioural Intervention Program for the Prevention of Type 2 Diabetes Among American Indian Youth: The Tribal Turning Point Study.

Pediatric obesity · 2025 · PMID 40884258

BACKGROUND: American Indian youth experience a high risk of overweight/obesity and type 2 diabetes. OBJECTIVES: To evaluate the effect of a behavioural intervention on diabetes risk factors among American Indian youth with overweight/obesity. METHODS: Between 2018 and 2023, youth (7-10 years) were randomised to the tribal turning point (TTP) intervention (n = 87) or control arm (n = 95). Community coaches delivered the core intervention in the first 6 months (10 group classes, 4 individual sessions with motivationa…

Rank96.0
Systematic review or meta-analysis

A Bibliometric Analysis of Disaster Nursing and Management Research: Global Trends, Key Insights, and Future Directions (1980-2024).

Nursing reports (Pavia, Italy) · 2026 · PMID 42506023

Background/Objectives: As the frequency and impact of global disasters intensify, the role of nursing in disaster management has become increasingly vital. Analyzing the evolution of disaster nursing research can inform preparedness strategies and enhance clinical responses. The aim of the study was to explore and visualize trends in research on disaster, disaster management, disaster nursing, and disaster preparedness from 1980 to 2024. Methods: A scientific mapping and performance analysis were conducted using Bi…

Rank96.0
Systematic review or meta-analysis

Environmental Disinfection in Long-Term Care Facilities-A Scoping Review.

Microorganisms · 2026 · PMID 42513914

Background: Long-term care facility (LTCF) residents are highly susceptible to healthcare-associated infections, and prevention is challenging given frailty, dementia, communal living, and resource constraints. Environmental surface and air contamination contribute to transmission. Novel no-touch automated disinfection technologies have been studied in hospitals, but evidence specific to LTCFs is scarce. This scoping review summarizes recent LTCF-focused interventions, their effectiveness, and implementation consid…

Rank95.6
Randomized controlled trial

The ManageHF Just-in-Time Adaptive Mobile App Interventions to Promote Self-Management and Improve Outcomes in Heart Failure: Randomized Controlled Trial.

JMIR mHealth and uHealth · 2026 · PMID 42520258

BACKGROUND: Heart failure (HF) is a major health care challenge in the United States, with approximately 900,000 older adults hospitalized annually. Gaps in self-management, including unrecognized worsening symptoms and failure to adhere to dietary sodium restriction, can reduce quality of life and precipitate hospital admissions. Existing mobile health approaches to HF self-management have produced mixed results, highlighting the need for innovative strategies to improve postdischarge outcomes in at-risk patients.…

Rank95.5
Randomized controlled trialResult signal: null

Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study.

Inflammatory bowel diseases · 2026 · PMID 42322204

BACKGROUND AND AIMS: Changes to the oral microbiome have been reported in patients with Crohn's disease (CD). The aim of this study was to determine the characteristics and dynamics of the oral microbiome in children randomized to 1 of 2 nutritional treatments for CD. METHODS: Participants (n = 54) in this randomized controlled trial (NCT02843100) received the Crohn's Disease Exclusion Diet (CDED) with either partial enteral nutrition (PEN; n = 28) or exclusive enteral nutrition (EEN; n = 26). The oral microbiome w…

Rank95.2
Randomized controlled trial

Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas.

The New England journal of medicine · 2026 · PMID 42341302

BACKGROUND: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is a standard treatment for relapsed or refractory B-cell non-Hodgkin lymphomas. Long-term results and curative potential remain uncertain. METHODS: We evaluated long-term outcomes in 38 patients with relapsed or refractory B-cell non-Hodgkin lymphomas (24 patients with large B-cell lymphoma and 14 with follicular lymphoma) who had been treated with CTL019 (now called tisagenlecleucel) - autologous T cells expressing CD19-directed, 4-1BB-costimula…

Rank92.0
Randomized controlled trial

Modeling of antibody waning after heterologous boosting with Ad5-nCoV in individuals primed with two-dose CoronaVac previously.

Human vaccines & immunotherapeutics · 2026 · PMID 41569047

Heterologous boosting with aerosolized or intramuscular Ad5-nCoV following a two-dose CoronaVac prime has been shown to induce higher antibody levels than a homologous CoronaVac booster. However, no specific modeling has been reported to characterize the kinetics of antibody waning for these heterologous regimens. By integrating longitudinal serological data from three randomized trials conducted in Jiangsu, China (NCT04892459, NCT04952727, NCT05043259), we applied linear mixed-effects models to establish both expo…

Rank92.0
Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 · PMID 42420160

OBJECTIVES: The PRIME randomized trial demonstrated improved neonatal outcomes using biomarker-guided risk stratification to target interventions to pregnancies at higher risk of preterm birth (PTB). This subgroup analysis evaluated its effectiveness in nulliparous pregnancies, a population with higher baseline risk and limited obstetric history to inform risk assessment. METHODS: PRIME (NCT04301518) was a 19‑center randomized controlled trial evaluating a screen‑guided care strategy using the IGFBP4/SHBG biomarker…

Rank91.8
Randomized clinical study

Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury.

American journal of respiratory and critical care medicine · 2026 · PMID 42150114

RATIONALE: Inflammation in acute respiratory distress syndrome (ARDS) and COVID-19 causes disruption of the alveolar-capillary barrier and tissue damage, which has been associated with increased mortality. Elevated pro-inflammatory plasma biomarker (specifically IL-6) levels reflect the degree of systemic inflammation and are linked to severity of lung injury. Understanding the causal pathway between inflammation, interventions, and patient outcomes could improve clinical care. OBJECTIVES: To assess IL-6 as a media…

Rank90.5
Randomized clinical study

Engaging Urban American Indian/Alaska Native Emerging Adults in a Nationwide Substance Use Intervention Randomized Controlled Trial: A Story of Recruitment during the COVID-19 Pandemic.

American Indian and Alaska native mental health research (Online) · 2026 · PMID 42378638

The majority of American Indian and Alaska Native (AI/AN) peoples reside in urban areas and experience significant health disparities relating to substance use. Nonetheless, very few randomized controlled trials (RCTs) have been conducted analyzing new substance use interventions for these populations, due, in part, to challenges with recruitment. This paper highlights recruitment strategies we employed from 2021-2023 in a study, Traditions, and Connections for Urban Native Americans (TACUNA), which analyzed the be…

Preclinical Research72 records
Rank106.0
Systematic review or meta-analysis

The potential role of indomethacin in COVID-19 management: A systematic review of therapeutic and mechanistic evidence.

New microbes and new infections · 2026 · PMID 42238848

BACKGROUND: Indomethacin has been proposed as a repurposed agent for COVID-19 due to its anti-inflammatory and potential antiviral effects against coronaviruses. However, the available evidence is limited, heterogeneous, and largely indirect, with a large observational NSAID study dominating the sample size without evaluating indomethacin-specific efficacy. METHODS: We conducted a PRISMA 2020-compliant systematic review registered in PROSPERO (CRD420251272994). Major databases and trial registries were searched fro…

Rank96.0
Systematic review or meta-analysis

Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review.

EBioMedicine · 2026 · PMID 42520549

BACKGROUND: The COVID-19 pandemic created a unique situation in which researchers repurposed human models of varying complexity to investigate SARS-CoV-2, providing the opportunity to analyse their contribution across organs. METHODS: We conducted a systematic review of 558 studies, divided into pandemic and post-pandemic periods, to assess how human models were applied to investigate host factors, viral replication of SARS-CoV-2, immune responses, and to evaluate reporting quality. FINDINGS: Our analysis revealed …

Rank94.6
Randomized controlled trial

Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study.

Nutrition research (New York, N.Y.) · 2025 · PMID 39889684

Viral infections are a global public health threat, reaffirming the importance of immune function. We previously identified Lactobacillus crispatus strain KT-11 (KT-11) and found that heat-sterilized KT-11 affect counts of T cell and dendritic cell in vitro, as well as promoted immunoglobulin A production and prevented weight loss caused by influenza virus infection in vivo. It was hypothesized that heat-sterilized KT-11 affects immune cell count/activity even in healthy individuals. We conducted a pilot study to e…

Rank88.4
Randomized clinical study

Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix.

The Journal of infectious diseases · 2026 · PMID 42446369

BACKGROUND: Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a half-life-extended monoclonal antibody optimized using artificial intelligence. It targets the conserved spike S2 stem helix, a region subject to limited selective pressure from antibody responses induced by natural infection or vaccination. METHODS: Pre-clinical safety studies were conducted in cynomolgus monkeys. In the first-in-human trial, healthy adult…

Rank87.2
Randomized clinical study

A Randomized, Double-Blind, Placebo-Controlled Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Outer Membrane Vesicle (OMV) Platform-Based Vaccine Administered Intranasally to Healthy Adults.

Vaccines · 2026 · PMID 42506612

Background: The COVID-19 pandemic exposed critical gaps in pandemic preparedness and highlighted the need for vaccine platforms capable of rapid adaptation. Outer membrane vesicle (OMV)-based platforms utilizing vesicles derived from genetically detoxified Neisseria meningitidis serogroup B (Nm-nOMV) represent a promising plug-and-play approach. Methods: This Phase I, first-in-human, randomized, double-blind, placebo- and OMV-controlled trial, evaluated safety, tolerability, and immunogenicity of intranasally admin…

Rank85.0
Randomized clinical study

Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective.

Lancet (London, England) · 2026 · PMID 42379196

mRNA vaccines represent a transformative advance in vaccinology, combining rapid development timelines, scalable manufacturing, and strong immunogenicity with a favourable safety profile. Global deployment of mRNA vaccines during the COVID-19 pandemic provided an unprecedented real-world evaluation of this platform, with billions of doses administered across diverse populations. In this Review, we critically examine the safety and efficacy of mRNA vaccines from mechanistic, preclinical, clinical, and public health …

Rank69.1
Prospective cohort studyResult signal: null

Mental Health in Fertile and Infertile Women During the COVID-19 Pandemic: A Comparative Cohort Study.

JBRA assisted reproduction · 2026 · PMID 42441892

OBJECTIVE: To assess the impact of the COVID-19 pandemic on symptoms of anxiety, depression, and stress among infertile and fertile women. METHODS: This prospective cohort study evaluated psychological distress using the 42-item Depression, Anxiety and Stress Scale (DASS-42) at two time points: during the early pandemic (Phase 1) and after six months (Phase 2). The study included infertile women whose embryo transfers were postponed (n=71) and fertile women who had given birth over six months earlier without fertil…

Rank66.6
Prospective cohort studyResult signal: harm

Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness.

American journal of physiology. Lung cellular and molecular physiology · 2022 · PMID 35608267

Critically ill patients manifest many of the same immune features seen in coronavirus disease 2019 (COVID-19), including both "cytokine storm" and "immune suppression." However, direct comparisons of molecular and cellular profiles between contemporaneously enrolled critically ill patients with and without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited. We sought to identify immune signatures specifically enriched in critically ill patients with COVID-19 compared with patients without COVI…

Rank45.0
Other PubMed-indexed publication

T cell-associated immunity induced by heterologous recombinant BCG and purified protein vaccination confers cross-variant protection against SARS-CoV-2.

Human vaccines & immunotherapeutics · 2026 · PMID 42423335

Previously, we have developed a recombinant BCG-based vaccine (rBCG) expressing a chimeric protein with spike and nucleocapsid epitopes (rChimera) to combine BCG's innate immune training capacity with SARS-CoV-2-specific adaptive immune responses. The heterologous prime-boost rBCG/rChimera+Alum regimen induced strong humoral and cellular immunity, conferring protection against the ancestral Wuhan strain in K18-hACE2 mice. Here, we used knockout mice lacking functional B cells, CD4+, or CD8+ T lymphocytes expressing…

Rank45.0
Other PubMed-indexed publication

A Conserved Natural Killer Cell Transcriptional Fingerprint in Rhesus Macaque Models of Acute Viral Infections.

AIDS research and human retroviruses · 2026 · PMID 42272153

Natural killer (NK) cell activation and function are controlled by highly complex transcriptional programs. To leverage NK cells against human immunodeficiency virus and other diseases, a more complete understanding of signaling and metabolic dynamics is needed. In this study, we utilize a rhesus macaque (RM) model to define the transcriptomic profile of NK cells during acute lentiviral infection and to map the changes in this profile as infection progresses to the early chronic phase. Using a novel summary gene se…

Rank45.0
Other PubMed-indexed publication

Structure-guided optimization of N-(5-((2-oxopropyl) thio)-1,3,4-thiadiazol-2-yl) propionamide frameworks as potent SARS-CoV-2 Mpro inhibitor for treating coronavirus disease.

Bioorganic chemistry · 2026 · PMID 42314596

The global outbreak of COVID-19, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in over 774 million cases and 7 million deaths worldwide since January 2020. Although widespread vaccination has been instrumental in reducing transmission and disease severity, there is a persistent and urgent need for effective treatments. This has made the virus's main protease (Mpro), a key enzyme in its replication cycle, a leading target for drug development. In the current research work, a sc…

Rank45.0
Other PubMed-indexed publication

Pleiotropic effects of direct oral anticoagulants on the coagulation-inflammation-endothelium axis: A phenotype-stratified narrative review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026 · PMID 42462434

AIMS: Direct oral anticoagulants (DOACs) - dabigatran (a thrombin inhibitor) and rivaroxaban, apixaban, and edoxaban (factor Xa [FXa] inhibitors) - modify oxidative stress, endothelial inflammation, and barrier integrity beyond anticoagulation. We ask whether this reflects distinct pharmacology or silencing of proteases at protease-activated receptors (PARs), and propose a three-condition framework for when it becomes clinically measurable. METHODS: Narrative review (PubMed, Scopus, Web of Science; primary search 2…

Rank45.0
Other PubMed-indexed publication

Multiple monovalent COVID-19 PHH-1V vaccine adaptations elicit homologous and cross-neutralizing antibody responses in mice.

Vaccine · 2026 · PMID 42242009

As SARS-CoV-2 continues to evolve, rapidly adaptable COVID-19 vaccines remain essential. We evaluated monovalent, variant-adapted PHH-1V-based vaccine constructs in BALB/c mice after two-dose primary vaccination and as heterologous boosters in mRNA-primed animals. Adaptations comprised Omicron XBB.1.16, JN.1, XEC, and LP.8.1 receptor-binding domain (RBD) homodimers (2 μg/dose) in squalene-based adjuvant. Immunogenicity on day 14 post-vaccination was assessed by pseudovirus-based neutralization and RBD-specific IgG …

Rank45.0
Other PubMed-indexed publication

Molecular screening for active severe acute respiratory syndrome coronavirus 2 infections among non-human primates in Indonesia.

The Journal of veterinary medical science · 2026 · PMID 42091566

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an ongoing public health concern, and its zoonotic nature increases the risk of cross-species transmission between humans and animals. Non-human primates (NHPs) are particularly susceptible because of the high similarity in angiotensin-converting enzyme 2 (ACE2) critical residues compared to those in humans, especially among catarrhine species. Therefore, surveillance of NHP populations is essential, particularly in Indonesia, a megadiverse nation h…

Rank45.0
Other PubMed-indexed publication

Molecular surveillance of coronaviruses in livestock in northern Vietnam.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2026 · PMID 42424669

Coronavirus (CoV) infections continue to pose a significant challenge to global public health and food security. The COVID-19 pandemic has underscored the importance of One Health approaches and improved surveillance systems. This is due to the considerable potential of CoVs to infect a broad spectrum of hosts and cause respiratory diseases. The present study investigated CoVs circulating in livestock in northern Vietnam using molecular detection and phylogenetic analysis. A total of 412 samples collected from live…

Rank45.0
Other PubMed-indexed publication

Novel vaccine platforms for respiratory viruses: a review of licensed vaccines and candidates in late-stage development.

Expert review of vaccines · 2026 · PMID 42083745

INTRODUCTION: Respiratory infections with influenza, respiratory syncytial virus (RSV), and SARS-CoV-2 are a major cause of global mortality. Vaccination is a cornerstone of disease prevention, though traditional platforms face challenges. Recently, several vaccines utilizing mRNA and adenovirus platforms were brought to the market, with additional vaccines undergoing Phase 3 clinical testing. AREAS COVERED: This review assesses vaccine literature primarily from 2020 to the present, using National Library of Medici…

Rank45.0
Other PubMed-indexed publication

Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication.

Stem cell reports · 2026 · PMID 42492515

While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoid (CBO) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages. We found that enhanced corticogenesis and gliogenesis during maturation are associated with substantial alterations in lipid metabolism, functionally linking these processes to coordinated molecular and functional brain development.…

Rank45.0
Other PubMed-indexed publication

Histological effects of intranasal clove essential oil on the olfactory bulb in a rat model of depression.

Tissue & cell · 2026 · PMID 41980326

BACKGROUND: depression is the most widespread psychiatric disorder, making it the fourth leading cause of death among adults. The olfactory system is a component of the limbic system. Repeated exposure to stressful events has been reported to affect emotions and olfactory perception. Clove oil is an essential oil that exhibits immunomodulatory properties and is used in the recovery of olfactory dysfunctions during the COVID-19 outbreak. AIM: Detect the potential hazards of stress-induced depression on the olfactory…

Rank45.0
Other PubMed-indexed publication

A Wireless Battery-Free Probe-Free Disposable Electrical-Digital-PCR Chip.

IEEE transactions on biomedical circuits and systems · 2026 · PMID 41961575

As the most fundamental and widely-used technique in molecular diagnostics, polymerase chain reaction (PCR) plays a crucial role across various applications including epidemic surveillance and medical diagnosis. For the numerous epidemics such as COVID-19, the massive and frequent detection has challenged the PCR equipment in system miniaturization and hardware cost efficiency as well as rapid and precise detection. In conventional methods, fluorescence-PCR requires huge costly optical instruments, and the DNA-Prob…

Rank34.8
Preclinical or laboratory study

Virologic insights from the phase 3 REDPINE trial: remdesivir in renally impaired and immunocompromised patients with COVID-19.

Antimicrobial agents and chemotherapy · 2026 · PMID 42429789

Remdesivir inhibits the SARS-CoV-2 RNA-dependent polymerase (Nsp12). Here, we present virology analyses from the Phase 3 REDPINE trial in participants with impaired kidney function hospitalized for COVID-19 and treated with remdesivir or placebo for 5 days. Out of 243 participants enrolled and treated in the study, 42 participants had solid organ transplantation (SOT) and received immunosuppressive medication prior to and during the study. Nasopharyngeal swabs were collected at baseline and through Day 29. Virology…

Rank32.6
Preclinical or laboratory study

BLIMP-1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses.

Immunology and cell biology · 2026 · PMID 42448314

BLIMP-1, a transcriptional repressor initially identified in plasma B-cell differentiation, also regulates CD8+ T cells and is differentially expressed between naïve and effector/memory CD4+ T cells. However, the functions of BLIMP-1 in human CD4+ regulatory T cells (Tregs) remain unclear. We found BLIMP-1 mRNA levels were low in naïve Tregs from thymus and cord blood, but high in effector/memory Tregs from adult peripheral blood. We confirmed the expression of BLIMP-1 mRNA by microarray of healthy T-cell populatio…

Rank32.6
Preclinical or laboratory studyResult signal: mixed

High levels of miR-146a-5p in COVID-19 patients are associated with Klebsiella lung coinfection.

Frontiers in immunology · 2026 · PMID 42495606

BACKGROUND: Bacterial coinfections in COVID-19 patients present significant clinical challenges, particularly in severe cases. Previous studies have highlighted the role of microRNAs (miRNAs) in regulating immune responses, with miR-146a-5p and miR-21-5p implicated in inflammation and immune modulation. This study examines the effect of bacterial coinfections on the expression levels of these miRNAs in patients with severe COVID-19. METHODS: We conducted a cohort study involving Mexican mestizo patients ≥18 years h…

Rank31.6
Preclinical or laboratory study

Deep learning-driven 3-D histopathology method: a pipeline for cellular-resolution myocarditis analysis.

American journal of physiology. Heart and circulatory physiology · 2026 · PMID 42294766

Infiltrative cardiovascular diseases are characterized by complex spatial distributions of abnormal tissue that hinder accurate diagnosis and therapeutic monitoring. Conventional two-dimensional (2-D) histopathological analysis often fails to capture their full extent, limiting quantitative assessment of disease burden and treatment response. We present a Linux-optimized, Cellular-resolution Organ Digital Analysis (CODA) pipeline for quantitative three-dimensional (3-D) reconstruction of whole murine hearts at cell…

Rank30.0
Preclinical or laboratory study

From trial site to research emerging research hub: mapping Ghana's vaccine research ecosystem, 1977-2025.

Health research policy and systems · 2026 · PMID 42482056

BACKGROUND: Ghana's vaccine research ecosystem has evolved substantially alongside national and global immunisation efforts. However, the extent and distribution of research activity across the full vaccine development continuum have not been systematically synthesised. This review maps peer-reviewed publications and institutional reports across a nine-stage vaccine development framework from 1977 to 2025, comparing patterns between the pre-pandemic (2000-2020) and post-pandemic (2021-2025) periods. MAIN BODY: Befo…

Rank30.0
Preclinical or laboratory study

Consistent functional properties of MSC-exosomes from different batches revealed by comparative multi-omics, bioinformatics and functional tests.

Stem cell research & therapy · 2026 · PMID 42482105

BACKGROUND: Mesenchymal stromal cell-derived exosomes (MSC-EXOs), also called Extracellular Vesicles (EVs), exhibit anti-inflammatory effects in various diseases and are being developed for clinical use. For instance, MSC-EXO promotes skin healing post-laser therapy and improves outcomes in severe COVID-19. Selecting an optimal cellular source is critical for the therapeutic development of MSC-EXO. It has been suggested that GMP-produced MSC-exosomes have slightly different molecular content. This study therefore a…

Promising Experimental Therapies64 records
Rank98.1
Randomized controlled trial

Epcoritamab monotherapy or epcoritamab with lenalidomide as first-line therapy for patients with diffuse large B-cell lymphoma (EPCORE DLBCL-3): primary analysis of an open-label, multicentre, randomised, phase 2 trial.

The Lancet. Haematology · 2026 · PMID 42285113

BACKGROUND: Anthracycline-free regimens are needed for older adults with newly diagnosed diffuse large B-cell lymphoma (DLBCL). We aim to evaluate the efficacy and safety of fixed-duration epcoritamab monotherapy versus epcoritamab with lenalidomide in this patient population. METHODS: This open-label, multicentre, randomised, phase 2 trial was conducted at 44 hospitals across 11 countries in Europe and Asia. Patients had newly diagnosed, histologically confirmed CD20-positive large B-cell lymphoma, were ineligible…

Rank97.6
Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.5
Randomized controlled trial

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

Human vaccines & immunotherapeutics · 2026 · PMID 41627968

A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase 1/2 clinical trial. This stratified, observer-blinded study randomly assigned healthy adults (18-75 years) to receive mRNA-1073 (25-µg, 50-µg, or 100-µg) + placebo, mRNA-1…

Rank97.2
Randomized controlled trial

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy · 2026 · PMID 42241901

BACKGROUND: During the COVID-19 pandemic, Mesenchymal Stromal Cells (MSCs) were rapidly proposed as a therapeutic option for Acute Respiratory Distress Syndrome (ARDS) based on their immunomodulatory properties. We report the results of COVIDMES, a multicenter trial initiated within a public blood and tissue bank infrastructure during unprecedented period of volatility and scientific uncertainty of the first pandemic waves. AIMS: To evaluate the safety, feasibility and exploratory efficacy of Wharton's Jelly-derive…

Rank97.1
Randomized controlled trial

CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial.

EBioMedicine · 2026 · PMID 42315445

BACKGROUND: APOE ε4 carriers have increased Alzheimer's disease risk and altered omega-3 metabolism. No large-scale prevention trials have tested high-dose docosahexaenoic acid (DHA) supplementation specifically in non-demented APOE ε4 carriers with low baseline omega-3 intake for early intervention. METHODS: We conducted a phase IIa 24-month, randomised, double-blind, placebo-controlled trial (NCT03613844) at the University of Southern California between September 2018 and May 2024. Participants aged 55-80 years w…

Rank96.7
Randomized controlled trialResult signal: null

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir-ritonavir in patients with COVID-19.

British journal of clinical pharmacology · 2026 · PMID 41869741

AIMS: The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans. In this study, we report the secondary endpoints from the phase 2a randomized, double-blind, 2 × 2 factorial placebo-controlled FLARE trial, which studied the combination of favipiravir and lopinavir-ritonavir. METHODS: Populatio…

Rank95.2
Randomized controlled trial

Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas.

The New England journal of medicine · 2026 · PMID 42341302

BACKGROUND: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is a standard treatment for relapsed or refractory B-cell non-Hodgkin lymphomas. Long-term results and curative potential remain uncertain. METHODS: We evaluated long-term outcomes in 38 patients with relapsed or refractory B-cell non-Hodgkin lymphomas (24 patients with large B-cell lymphoma and 14 with follicular lymphoma) who had been treated with CTL019 (now called tisagenlecleucel) - autologous T cells expressing CD19-directed, 4-1BB-costimula…

Rank94.6
Randomized controlled trialResult signal: null

Umbilical cord mesenchymal stromal cells for respiratory complications of COVID-19 infection (ProTrans): phase II randomized clinical trial.

Cytotherapy · 2026 · PMID 42134096

BACKGROUND: Severe COVID-19 is characterized by an aberrant immune response leading to systemic inflammation, organ dysfunction and high mortality among hospitalized patients. Mesenchymal stromal cells (MSCs), due to their immunomodulatory and tissue-reparative properties, are a potential therapeutic option. This study evaluated the safety of Wharton's Jelly-derived MSCs (WJ-MSCs) in patients with severe COVID-19 pneumonia. METHODS: ProTrans19+ is a phase II, randomized, double-blind, placebo-controlled trial. Adul…

Rank92.0
Randomized controlled trial

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42268674

This Phase 1 clinical trial evaluated the safety and immunogenicity of COVAC-2, a recombinant protein subunit vaccine as a heterologous booster in adults previously immunized with authorized COVID-19 vaccines (NCT05226702). COVAC-2 contains the SARS-CoV-2 S1 spike protein subunit adjuvanted with Sepivac SWE™, an open-access oil-in-water adjuvant. Sixty participants were randomized to receive a single intramuscular dose of COVAC-2 (10 µg or 25 µg) or placebo, with follow-up through Day 180. The vaccine was well tole…

Rank92.0
Randomized controlled trial

Nemolizumab in prurigo nodularis up to 100 weeks: OLYMPIA LTE interim analysis.

Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 · PMID 41405008

BACKGROUND: Prurigo nodularis (PN) is a neuroimmune skin disease characterized by the presence of chronic itch (≥6 weeks) and multiple white-pink papules, nodules and/or plaques. OBJECTIVES: The OLYMPIA long-term extension (OLYMPIA-LTE) trial evaluates long-term, over 184 weeks, safety and efficacy of nemolizumab in adults with moderate-to-severe PN. METHODS: Adults with moderate-to-severe PN, who completed phase 2b (NCT03181503) and phase 3 (OLYMPIA 1&2) lead-in trials, were eligible for the ongoing OLYMPIA-LTE tr…

Rank92.0
Randomized controlled trial

A Multipart Phase 1 Study to Assess Safety and Pharmacokinetics of Ibuzatrelvir in Healthy Participants and Dose Selection for a Dose-Ranging Study.

Clinical and translational science · 2026 · PMID 42433209

COVID-19 continues to be a threat to global health and a burden on healthcare systems. There is an ongoing need for COVID-19 antiviral therapies that are safe and effective across broad patient populations. Ibuzatrelvir is a potent, selective inhibitor of the SARS-CoV-2 main protease and demonstrated favorable properties for clinical development. We report safety, tolerability, and pharmacokinetic data for ibuzatrelvir from a phase 1 first-in-human study in healthy adults. Study parts evaluated ibuzatrelvir as sing…

Rank91.8
Phase III clinical trial

Nirmatrelvir/Ritonavir for the Treatment of COVID-19 in Children Aged 6 Years and Older.

Pediatrics · 2026 · PMID 42342255

OBJECTIVES: This ongoing phase 2/3 interventional, open-label study evaluated nirmatrelvir/ritonavir (NMV/r) in pediatric participants with mild-to-moderate COVID-19 at risk for severe disease (due to underlying medical conditions). Primary objectives were pharmacokinetics (PK) and safety. We report data from participants aged at least 6 years. METHODS: Twice daily (BID) oral NMV/r was administered for 5 days to participants aged at least 6 years weighing at least 40 kg (Cohort 1) or 20 to <40 kg (Cohort 2). Day 1 …

Rank89.5
Randomized clinical study

Clinical checklists of multicomponent non-pharmacological interventions for delirium management in adult patients in non-ICU inpatient healthcare settings: a rapid review.

BMJ open · 2026 · PMID 42366006

OBJECTIVES: To identify clinical checklists of multicomponent non-pharmacological interventions for the prevention and treatment of delirium used in non-intensive care unit inpatient healthcare settings, their content and reported implementation. DESIGN: Rapid review. DATA SOURCES: Medline, Embase, PsycINFO, CINAHL and Cochrane CENTRAL were searched from 1 January 1999 to 31 March 2022 and updated on 16 January 2025. A comprehensive grey literature search, including websites of guideline development groups and inte…

Rank89.1
Randomized clinical study

Synchronous Remote Teaching for Neurological Examination Training in Fifth-Year Medical Students: Quasi-Experimental Study.

JMIR medical education · 2026 · PMID 42456133

BACKGROUND: The use of remote teaching in medical education has increased since the COVID-19 pandemic. However, the effectiveness of synchronous remote teaching for specific psychomotor components of the neurological examination, such as tendon reflex assessment, remains underexplored. OBJECTIVE: This study aimed to evaluate the short-term effectiveness of synchronous remote teaching compared with traditional in-person teaching for training medical students in tendon reflex examination skills and related neurologic…

Rank85.0
Randomized clinical study

Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.

International journal of molecular sciences · 2026 · PMID 42450260

The concurrent circulation of influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unveiled complex host-pathogen interactions governed by temporal dynamics of innate immune activation. This narrative review synthesizes evidence from human air-liquid interface (ALI) epithelial models, animal studies (hamster, ferret), clinical cohorts, and randomized controlled trials (2015-2026) to delineate the molecular mechanisms underlying viral interference between these two major respi…

Rank85.0
Randomized clinical study

Production of a Health Awareness Video on Precautionary Measures Against Respiratory Infectious Diseases for Public Transportation Drivers: Protocol for a Scoping Review, a Delphi Study, and a Randomized Controlled Trial.

JMIR research protocols · 2026 · PMID 42324927

BACKGROUND: The public transportation system is a high-risk medium for respiratory infectious disease (RID) transmission. Health awareness videos are integral to disseminating knowledge, elevating health-risk perceptions, and enhancing attitudes toward precautionary measures against RID, as per the Health Belief Model and Cognitive Dissonance theory. OBJECTIVE: This study aimed to produce and evaluate an evidence-based health awareness video on precautionary measures against RID among public transportation drivers …

Rank82.3
Phase II clinical trial

Lucinactant, a Synthetic Surfactant for the Treatment of Acute Respiratory Distress Syndrome Caused by COVID-19: Phase 1/2A Trial.

JMIR formative research · 2026 · PMID 42536986

BACKGROUND: One unique feature of COVID-19-associated acute respiratory distress syndrome (ARDS) is surfactant deficiency because SARS-CoV-2 specifically attacks alveolar type 2 cells. OBJECTIVE: In this study, we evaluated the effects of a synthetic surfactant (lucinactant) therapy in patients with COVID-19-associated ARDS. METHODS: This open-label multicenter phase 1/2A trial enrolled adult patients with COVID-19-associated ARDS who were within 7 days of mechanical ventilation initiation. Lucinactant (160 mL or a…

Rank80.0
Phase II clinical trial

Bendamustine/Rituximab Induction Followed by Venetoclax/Rituximab Consolidation in Frontline Treatment of Chronic Lymphocytic Leukemia: A Phase 2 Multi-Center Study.

Hematological oncology · 2026 · PMID 42241337

We hypothesized that a time-limited frontline treatment strategy with abbreviated chemoimmunotherapy followed by targeted consolidation could achieve durable disease control with manageable toxicity in CLL. We evaluated the safety and efficacy of short-course bendamustine/rituximab (BR) induction followed by venetoclax/rituximab (VR) consolidation. In a multicenter, single-arm Phase 2 trial (NCT03609593), previously untreated CLL/SLL needing therapy received BR for three 28-day cycles followed by venetoclax ramp-up…

Rank78.4
Phase II clinical trialCorrection flagged

Teclistamab-based induction treatment in transplant-eligible, newly diagnosed multiple myeloma: a phase 2 trial.

Nature medicine · 2026 · PMID 42350642

Advancements in frontline therapies have substantially improved outcomes in newly diagnosed multiple myeloma (NDMM); however, many patients will not achieve deep responses and will relapse. Teclistamab, a BCMA×CD3 bispecific antibody, in combination with daratumumab, has demonstrated strong efficacy in relapsed/refractory multiple myeloma versus standard of care as early as first relapse. This ongoing phase 2 GMMG-HD10/DSMM-XX (MajesTEC-5) study evaluates teclistamab-based regimens in transplant-eligible NDMM. In t…

Rank73.0
Multicenter clinical study

Clinical and Cost-Effectiveness of Shared Decision Making: Evidence from a Prospective Multicenter Study Evaluating a Hospital-Based Intervention in Germany.

Medical decision making : an international journal of the Society for Medical Decision Making · 2026 · PMID 42249569

ObjectiveTo evaluate the clinical and cost-effectiveness of SHARE TO CARE (S2C), a complex intervention for hospital-wide, systematic implementation of shared decision making.MethodsWe analyzed clinical effectiveness, health care resource utilization, and implementation costs of S2C from the statutory health insurance perspective using a quasi-experimental difference-in-differences approach with evidence from the Department of Neurology. Clinical outcomes included inpatient hospital admissions, emergency department…

Rank68.4
Phase I clinical trial

The safety, reactogenicity, and immunogenicity of the self-amplifying mRNA COVID-19 vaccine GRT-R910 as a booster in healthy adults.

Vaccine · 2026 · PMID 41740461

BACKGROUND: GRT-R910 (Gritstone bio, Inc), a self-amplifying mRNA vaccine expressing SARS CoV-2 (D614G) spike protein and T-cell epitopes, was evaluated as a booster vaccine in a phase 1 study in 2021-2022. METHODS: This open-label, dose escalation study enrolled healthy adults ≥112 days after completion of primary COVID-19 vaccination, booster of approved mRNA COVID-19 vaccine, or known SARS-CoV-2 infection. Persons aged 18-60 years received single doses of 3 or 6 μg GRT-R910 (n = 10/group). Persons >60 years of a…

Rank68.0
Phase I clinical trial

The safety and efficacy of human umbilical cord mesenchymal stem cell for acute respiratory distress syndrome: an open-label and multicenter phase 1 clinical trial.

Frontiers in immunology · 2026 · PMID 42358964

TRIAL DESIGN: Acute Respiratory Distress Syndrome (ARDS) remains a life-threatening critical illness with high mortality and limited specific therapies. This open-label, multicenter Phase I clinical trial aimed to evaluate the safety, tolerability, and preliminary efficacy of allogeneic human umbilical cord mesenchymal stem cells (hUC-MSCs, BC-U001) in patients with mild-to-moderate ARDS. A total of 12 eligible patients were enrolled into three dose groups following a "3 + 3" dose-escalation design from 2019 to 202…

Rank65.0
Prospective cohort study

SARS-CoV-2 and diabetes: a post-pandemic reappraisal.

Diabetologia · 2026 · PMID 42362970

The COVID-19 pandemic was a dynamic and often confusing period for clinical and biomedical research. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread globally, knowledge accumulated rapidly through publications that were frequently based on preliminary or sometimes conflicting evidence, yet these papers played a critical role in shaping evolving medical, research and societal responses. Early in the pandemic, diabetes emerged as one of the strongest predictors of severe COVID-19 outcomes and m…

Rank65.0
Phase I clinical trial

Pharmacokinetics, Safety, and Tolerability of Obeldesivir in Healthy Japanese and White Participants.

European journal of drug metabolism and pharmacokinetics · 2026 · PMID 42104169

BACKGROUND AND OBJECTIVE: Obeldesivir is an orally administered prodrug of the nucleoside GS-441524. In vitro and preclinical studies have shown that obeldesivir can inhibit severe acute respiratory syndrome coronavirus 2, respiratory syncytial virus, and filoviruses with a high barrier to resistance. Prior population pharmacokinetic modeling has shown that certain factors, such as coronavirus disease 2019 (COVID-19), body weight, and renal function, can impact GS-441524 exposure. This study aimed to evaluate the p…

Rank50.3
Other PubMed-indexed publication

Impact of Respiratory Infections on Health-Related Quality of Life Among Children: Using PedsQL, EQ-5D-Y, and EQ-TIPS.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026 · PMID 41692382

OBJECTIVES: Evidence on the impact of respiratory tract infections (RTIs) on pediatric health-related quality of life (HRQL) remains limited. This study aimed to evaluate the psychometric properties of HRQL measurement instruments for children with RTIs using longitudinal assessments. METHODS: HRQL was assessed in children younger than 16 years with RTIs using proxy-reported versions of EuroQol 5-Dimension Youth version, 3-Level (EQ-5D-Y-3L), the experimental EuroQol Toddler and Infant Populations v2.0 (EQ-TIPS), a…

Prospective Cohort Studies66 records
Rank97.2
Randomized controlled trial

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy · 2026 · PMID 42241901

BACKGROUND: During the COVID-19 pandemic, Mesenchymal Stromal Cells (MSCs) were rapidly proposed as a therapeutic option for Acute Respiratory Distress Syndrome (ARDS) based on their immunomodulatory properties. We report the results of COVIDMES, a multicenter trial initiated within a public blood and tissue bank infrastructure during unprecedented period of volatility and scientific uncertainty of the first pandemic waves. AIMS: To evaluate the safety, feasibility and exploratory efficacy of Wharton's Jelly-derive…

Rank96.0
Randomized controlled trialResult signal: null

A Randomized Controlled Trial of Ultrasound-Assisted versus Traditional Landmark Lumbar Puncture in the Neonatal and Infant Population.

The Journal of pediatrics · 2026 · PMID 42103066

OBJECTIVE: To evaluate whether static ultrasound improves first-attempt, nontraumatic lumbar puncture (LP) success compared with the traditional landmark technique in infants admitted to a neonatal intensive care unit (NICU). STUDY DESIGN: We conducted a prospective, randomized controlled trial at a single tertiary-care NICU between August 2016 and January 2020. Infants ≤6 months of age requiring LP were randomized 1:1 to ultrasound-assisted or traditional landmark LP. The primary outcome was first-attempt, nontrau…

Rank95.5
Randomized controlled trialResult signal: null

Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study.

Inflammatory bowel diseases · 2026 · PMID 42322204

BACKGROUND AND AIMS: Changes to the oral microbiome have been reported in patients with Crohn's disease (CD). The aim of this study was to determine the characteristics and dynamics of the oral microbiome in children randomized to 1 of 2 nutritional treatments for CD. METHODS: Participants (n = 54) in this randomized controlled trial (NCT02843100) received the Crohn's Disease Exclusion Diet (CDED) with either partial enteral nutrition (PEN; n = 28) or exclusive enteral nutrition (EEN; n = 26). The oral microbiome w…

Rank95.0
Randomized controlled trial

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings.

Frontiers in immunology · 2024 · PMID 39906744

BACKGROUND: Cytokine release triggered by a hyperactive immune response is thought to contribute to severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2)-related respiratory failure. Bruton tyrosine kinase (BTK) is involved in innate immunity, and BTK inhibitors block cytokine release. We assessed the next-generation BTK inhibitor zanubrutinib in SARS-CoV-2-infected patients with respiratory distress. METHOD: Cohort 1 had a prospective, randomized, double-blind, placebo-controlled design; cohort 2 had a s…

Rank79.7
Multicenter clinical study

A 3-Tier AI Model for COVID-19 Triage Using Pharyngeal Images: Algorithm Development and Validation.

JMIR formative research · 2026 · PMID 42475730

BACKGROUND: SARS-CoV-2 remains a common cause of acute respiratory illness; however, symptom-based triage poorly discriminates it from other febrile conditions. A recently developed artificial intelligence (AI)-powered pharyngeal camera acquires pharyngeal images and clinical data to assist in influenza diagnosis; leveraging this workflow, we evaluated an adjunct AI algorithm (COVID-19-AI) that reports high, medium, or low suspicion to guide whether SARS-CoV-2 testing should subsequently be performed. OBJECTIVE: Th…

Rank78.9
Multicenter clinical study

Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality.

JCI insight · 2025 · PMID 41212055

BACKGROUNDAccurate prognostic assays for COVID-19 represent an unmet clinical need. We sought to identify and validate early parsimonious transcriptomic signatures that accurately predict fatal outcomes.METHODSWe studied 894 patients enrolled in the prospective, multicenter Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) with peripheral blood mononuclear cells (PBMC) and nasal swabs collected within 48 hours of admission. Host gene expression was measured with RNA-Seq. We trained parsimonious prognostic …

Rank78.4
Multicenter clinical study

Clinical manifestations of adult patients requiring influenza-associated hospitalization in the pre-, during, and post-COVID-19 pandemic periods: An internet-based, prospective, multicenter, cohort study in Japan.

Respiratory investigation · 2026 · PMID 42119417

BACKGROUND: Influenza is a major concern, but it has been affected by the COVID-19 pandemic worldwide. The objective of this study was to clarify the differences in the clinical manifestations of severely ill patients infected with influenza in Japan among the pre-, during, and post-COVID-19 pandemic periods. METHODS: The clinical data of patients who were severely ill with influenza and required hospitalization were gathered and analyzed between September 2019 and August 2025 (6 influenza seasons) using an interne…

Rank78.2
Multicenter clinical study

Impact of Age on Bleeding, Stroke, and Mortality in Edoxaban-Treated Patients with Atrial Fibrillation: Results from the ETAF-TR Registry.

Drugs & aging · 2026 · PMID 42455491

BACKGROUND: Data on age-specific outcomes in patients with atrial fibrillation (AF) treated with edoxaban in real-world settings are limited; this prespecified analysis of the ETAF-TR study aimed to investigate the influence of age on prespecified clinical outcomes, including overt bleeding, major bleeding, ischemic stroke, all-cause mortality, major adverse cardiovascular events (MACE), and net clinical benefit. METHODS: The ETAF-TR study is a prospective, multicenter, observational registry conducted at 50 cardio…

Rank77.9
Multicenter clinical studyResult signal: harm

Long-Term Effect Of COVID-19 on Children's Lung Function: A Prospective Longitudinal Study.

Pediatric pulmonology · 2026 · PMID 42376911

INTRODUCTION-AIM: The study evaluates the long-term effect of COVID-19 on lung function in children, considering symptoms, physical examination findings, radiologic and laboratory evaluations during the acute infection period (AIP). MATERIAL AND METHODS: This prospective, longitudinal, multicenter study involved 270 patients with confirmed SARS-CoV-2 infection. Patients underwent pulmonary function tests (PFTs) (spirometry, diffusion capacity of the lung for carbon monoxide (DLCO), and plethysmography) at the 3rd a…

Rank77.5
Multicenter clinical study

Impact of early oral antiviral use for outpatients with COVID-19 on healthcare utilization and recovery (ANCHOR-02).

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42081967

OBJECTIVES: To evaluate the associations of early-phase oral antivirals with recovery in outpatients with COVID-19, regardless of baseline risk for severe disease, during the SARS-CoV-2 Omicron JN.1-/KP.3-dominant epidemic era. METHODS: This nationwide, multi-institutional (51 acute-care hospitals in Japan), prospective, registry-based cohort study enrolled outpatients aged ≥12 years with laboratory-confirmed COVID-19 within 5 days of symptom onset (February 1-October 31, 2024). Participants were compared between t…

Rank76.1
Multicenter clinical study

Gastrointestinal pathogens in paediatric patients with diarrhoea during the COVID-19 pandemic in Spain: a multicentre molecular-based prospective study.

European journal of pediatrics · 2026 · PMID 42390675

Gastroenteritis is a major cause of morbidity in young children worldwide. A prospective multicentre study was conducted from September 2020 to September 2021 in three tertiary hospitals in Spain to assess the burden of the gastrointestinal pathogens causing paediatric gastroenteritis in different Spanish regions, to understand the impact of COVID-19 pandemic in their incidence, and to assess potential risk factors for infection. Stool samples from children aged 0-59 months with acute or chronic diarrhoea were anal…

Rank75.9
Multicenter clinical studyResult signal: harm

High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

Journal of critical care · 2026 · PMID 42385526

BACKGROUND: Optimal corticosteroid dosing strategies remain unclear for severe coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU). This study compared mortality among patients treated with high-dose versus standard-dose corticosteroids. METHODS: This prospective cohort study included adult patients with COVID-19 ARDS, defined according to Berlin criteria for ARDS, across 22 centers in the Netherlands between March 2020 and January 2021. Mortality hazards were compared between pat…

Rank75.9
Multicenter clinical study

Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study.

The Lancet. Respiratory medicine · 2026 · PMID 42140220

BACKGROUND: Two biological subphenotypes in acute respiratory distress syndrome (ARDS) have been identified in retrospective analyses, with differential clinical outcomes and post-hoc responses to investigational treatments. The ability to identify biological subphenotypes in real-time is unknown. We aimed to evaluate the feasibility of using the multisite ISPY COVID Network to prospectively evaluate biological subphenotypes in real-time. METHODS: This prospective, observational, cohort study enrolled patients with…

Rank75.0
Prospective cohort study

Pre-pandemic care-seeking patterns and subsequent diagnoses of post-COVID condition, post viral fatigue syndrome, and exhaustion disorder: a registry-based cohort study of 208,050 Swedish women.

Scandinavian journal of primary health care · 2026 · PMID 41496460

BACKGROUND: Women are disproportionately diagnosed with symptom-based conditions, notably post-COVID condition (PCC). In Sweden, as of February 2022, 2.3% of PCR-verified female COVID-19 cases versus 1.6% of male cases had a PCC diagnosis. Post-viral fatigue syndrome (PVFS) and exhaustion disorder (ED), a common and relevant diagnosis in Sweden, share substantial symptom overlap with PCC. AIMS: To quantify the association between pre-pandemic, symptom-based primary-care visits and subsequent PCC, PVFS, and ED among…

Rank73.0
Multicenter clinical study

Clinical and Cost-Effectiveness of Shared Decision Making: Evidence from a Prospective Multicenter Study Evaluating a Hospital-Based Intervention in Germany.

Medical decision making : an international journal of the Society for Medical Decision Making · 2026 · PMID 42249569

ObjectiveTo evaluate the clinical and cost-effectiveness of SHARE TO CARE (S2C), a complex intervention for hospital-wide, systematic implementation of shared decision making.MethodsWe analyzed clinical effectiveness, health care resource utilization, and implementation costs of S2C from the statutory health insurance perspective using a quasi-experimental difference-in-differences approach with evidence from the Department of Neurology. Clinical outcomes included inpatient hospital admissions, emergency department…

Rank73.0
Multicenter clinical study

Turnover Intentions Among Intensive Care Healthcare Workers: Key Factors Influencing Decisions to Stay or Leave.

Acta anaesthesiologica Scandinavica · 2026 · PMID 42415569

BACKGROUND: Turnover among healthcare workers (HCWs) is highly prevalent in intensive care units (ICUs). Due to demanding workloads, stressful conditions, and increasing pressure to work more efficiently, this problem is likely to persist. Consequently, implementing proactive strategies to support HCWs retention is needed. This study aimed to examine associations between work environment factors and ICU HCWs' intentions to quit. METHODS: Based on data from a prospective, open-cohort, multicenter study of hospital f…

Rank72.9
Multicenter clinical study

Investigating the course of atopic eczema up to 1 year following completion of narrowband ultraviolet B phototherapy.

Clinical and experimental dermatology · 2026 · PMID 41668473

BACKGROUND: Narrowband (NB)-ultraviolet B (UVB) is a second-line treatment for chronic moderate-to-severe atopic eczema unresponsive to adequate topical therapy, and is known to induce good short-term improvement of eczema severity. However, it is unclear how adult patients fare with their eczema severity long after completion of a course of NB-UVB. OBJECTIVES: To investigate the severity of atopic eczema in adults, 1 year following completion of NB-UVB, using validated clinical activity measures. METHODS: We under…

Rank71.8
Prospective cohort study

Incidence of respiratory syncytial virus in adults ≥50 years during and following the COVID-19 pandemic in upper midwest USA: a community-based prospective cohort study.

BMJ open · 2026 · PMID 42481189

OBJECTIVE: Respiratory syncytial virus (RSV) is an important viral pathogen in children, older adults and adults with certain high-risk conditions. In our prospective community-based cohort study of adults 50 years and older before the COVID-19 pandemic, the incidence of RSV acute respiratory infection (ARI) was 48.6 cases/1000 person-years (PY), which decreased to near zero during the COVID-19 pandemic. Our objective was to determine the incidence of RSV-ARI during the 2 years following the initial phase of the pa…

Rank71.1
Prospective cohort study

Self-reported long COVID symptoms among Japanese adults: Findings of CARE Japan online questionnaire-based prospective cohort study.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2026 · PMID 42202985

INTRODUCTION: We conducted a comprehensive assessment of long COVID and associated risk factors, among an online cohort of Japanese adults in omicron dominant COVID-19 period in Japan. METHODS: We used data from the online questionnaire-based CARE Japan Study, that collected data on patient demographics and information on post-COVID-19 symptoms. Long COVID, was defined as the presence of ≥1 symptom for ≥3 months after the initial COVID-19 infection. We performed Kaplan-Meier survival analysis to estimate the restri…

Rank70.9
Prospective cohort studyResult signal: harm

Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network.

Human vaccines & immunotherapeutics · 2026 · PMID 42053343

Safety data on COVID-19 and influenza vaccination in immunocompromised and/or autoimmune pediatric populations remains limited. This study evaluated post-vaccination health events in this vulnerable population using active surveillance data from the Canadian National Vaccine Safety (CANVAS) Network. A prospective cohort of participants aged 6 months to 19 y, who self-identified with an autoimmune and/or immunocompromised condition, were followed across several Canadian provinces (2023-2025). Participants were vacci…

Rank70.2
Prospective cohort studyResult signal: harm

Newborn IgG and IgM antibodies to maternal SARS-CoV-2 infection in pregnancy and child neurodevelopmental outcomes.

Brain, behavior, and immunity · 2026 · PMID 41956300

Maternal immune activation is a hypothesized mechanism by which prenatal exposure to infection adversely impacts fetal brain development. SARS-CoV-2 IgG class antibodies generated to viral proteins in pregnancy are transferred across the placenta to the newborn. This study aimed to investigate the association between neonatal levels of IgG antibodies to SARS-CoV-2 nucleocapsid and spike proteins and risk of neurodevelopmental disorders (ND) among children with gestational SARS-CoV-2 exposure. Using a longitudinal p…

Rank70.0
Multicenter clinical study

Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle Treatment of Respiratory Failure from COVID-19: Endpoint Analysis of Expanded Access Safety Trial.

Stem cell reviews and reports · 2026 · PMID 42113080

The safety of an extracellular vesicle (EV) enriched secretome from bone marrow mesenchymal stem cells (BM-MSCs) was evaluated in a multi-site, prospective, expanded access trial as potential treatment for respiratory failure due to COVID-19. Subjects (103) received up to three doses of 15 mL IP every 72 h. The primary outcome was all cause 60-day mortality. Secondary outcomes included serious adverse events. One TEAE (grade 1 hyperpigmentation at the infusion site) related to IP occurred. 60-day mortality was 29% …

Rank70.0
Multicenter clinical study

Trajectories of lung recovery following COVID-19 in a prospective multicentric cohort study: Impact of sleep apnea and its treatment by continuous positive airway pressure.

Pulmonology · 2026 · PMID 41848886

BACKGROUND: Obstructive sleep apnoea (OSA) is associated with more severe forms of COVID-19. We investigated the impact of OSA and its treatment on lung recovery trajectories over the year following acute care for different COVID-19 severities. METHODS: Prospective multicentric (5 centres) cohort study, recruiting from June 2020 to April 2022. All patients with a non-fatal pulmonary presentation of COVID-19 were eligible. OSA diagnosis (apnoea-hypopnoea index [AHI] >5/h) was performed at inclusion. Pulmonary functi…

Rank69.4
Observational or cohort study

Spatial and neighborhood data in the collaborative cohort of cohorts for COVID-19 Research (C4R).

PloS one · 2026 · PMID 42485397

Neighborhood factors, encompassing social, built, and natural environments, may explain geographic differences in the impact of COVID-19 pandemic on populations. Data from pre-existing national, population-based cohorts could be leveraged to better understand how pre-existing conditions (both individual and neighborhood) contribute to risk factor development and disease progression. We catalogued spatial and neighborhood data in the Collaborative Cohort of Cohorts for COVID-19 Research (C4R), comprising 14 diverse …

Rank68.7
Prospective cohort study

Post-COVID-19 Thyroid Dysfunction and Autoimmune Ultrasound Changes: A 12-Month Prospective Cohort Study.

Medicina (Kaunas, Lithuania) · 2026 · PMID 42512896

Background and Objectives: Thyroid dysfunction has been increasingly reported during and after SARS-CoV-2 infection, yet prospective longitudinal studies integrating biochemical and imaging assessments remain limited. The aim of this study was to evaluate the evolution of thyroid function and structural changes during a 12-month follow-up after COVID-19 hospitalization. Materials and Methods: This prospective single-center cohort study included adult patients hospitalized with laboratory-confirmed COVID-19 between …

Quality Of Life75 records
Rank106.7
Systematic review or meta-analysis

Unveiling the genitourinary phenotype of long COVID: a systematic review and meta-analysis.

International urology and nephrology · 2026 · PMID 41796425

IMPORTANCE: Long COVID has been associated with persistent multisystemic manifestations. However, genitourinary alterations have not been formally recognized as a distinct phenotype despite growing reports suggesting their relevance for long-term morbidity and quality of life. OBJECTIVES: To determine the frequency and characteristics of genitourinary manifestations in patients with long COVID and to evaluate the evidence supporting the possible emergence of a genitourinary phenotype within long COVID. DATA SOURCES…

Rank106.4
Systematic review or meta-analysis

Effect of low-dose naltrexone for long COVID: a systematic review and meta-analysis.

BMJ open · 2026 · PMID 42463201

OBJECTIVE: Long covid is a debilitating chronic condition, and the effect of low-dose naltrexone (LDN) on its symptoms is unclear. We aimed to determine the effectiveness of LDN on symptoms of long covid. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase and Cochrane Library for published studies; ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) for registered ongoing studies were searched through 5 May 2026. ELIGIBILITY CRITERIA: We included randomised cont…

Rank100.0
Systematic review or meta-analysis

The use of patient-reported outcome questionnaires in patients with post-COVID-19 condition: a systematic review and meta-analysis.

Family practice · 2026 · PMID 42536797

BACKGROUND AND OBJECTIVE: Post-COVID-19 condition (PCC) is a complication of acute COVID-19, which often presents with a variety of symptoms. It can also impact individuals' overall well-being, capacity to carry out daily activities, engage in physical exercise, maintain employment, and their general quality of life. Therefore, this review aimed to examine the role of patient-reported outcome measures (PROMs) questionnaires in assessing patients with PCC through prevalence of abnormal tests. METHODS: We searched th…

Rank98.0
Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

CONTEXT: Advanced care planning (ACP) can reduce hospitalizations, increase quality of life, and align treatment with patient wishes, while lowering healthcare costs. However, healthcare providers' discomfort, lack of training, and patient anxiety may hinder ACP. Furthermore, disparities exist among minority and low-income groups. Growing research highlights the need for standardized definitions and broader implementation, especially post-COVID-19, incorporating digital tools, economic impacts, ethics, and family r…

Rank96.0
Randomized controlled trial

DiaBetter Together: Outcomes of a Randomized Controlled Trial Evaluating a Peer Mentor Behavioral Intervention for Young Adults With Type 1 Diabetes During the Transfer From Pediatric to Adult Care.

Diabetes care · 2026 · PMID 42201336

OBJECTIVE: Transition between pediatric and adult health care is complex, with high risk for loss to follow-up and suboptimal health outcomes for young adults with type 1 diabetes. This trial evaluated the efficacy of DiaBetter Together, a 12-month strengths-based behavioral intervention delivered by trained peer mentors. The intervention aimed to help young adults navigate the transfer process to promote optimal glycemic outcomes, shorten time to adult care follow-up, and improve psychosocial outcomes. RESEARCH DE…

Rank95.6
Randomized controlled trial

The ManageHF Just-in-Time Adaptive Mobile App Interventions to Promote Self-Management and Improve Outcomes in Heart Failure: Randomized Controlled Trial.

JMIR mHealth and uHealth · 2026 · PMID 42520258

BACKGROUND: Heart failure (HF) is a major health care challenge in the United States, with approximately 900,000 older adults hospitalized annually. Gaps in self-management, including unrecognized worsening symptoms and failure to adhere to dietary sodium restriction, can reduce quality of life and precipitate hospital admissions. Existing mobile health approaches to HF self-management have produced mixed results, highlighting the need for innovative strategies to improve postdischarge outcomes in at-risk patients.…

Rank93.3
Randomized clinical studyResult signal: null

Pre-Pandemic- and During-COVID-19 Anxiety and Depression Symptoms and Health-Related Quality of Life Were Similar in Injured Older Adults Enrolled in a Clinical Trial.

Geriatrics (Basel, Switzerland) · 2026 · PMID 42496356

Introduction: The Trauma Medical Home (TMH) randomized clinical trial tested the efficacy of a collaborative care intervention on the biopsychosocial recovery of older injured adults compared to usual care. Study enrollment occurred between 11 October 2017 and 13 October 2021 and study operations were impacted by the COVID-19 pandemic. It is important to measure the potential effects of COVID-19 on research study participants to ensure accurate reporting of results. The purpose of this secondary analysis was to com…

Rank92.0
Randomized clinical study

Herbal medicine (Kyungok-go) for fatigue in Long COVID patients: A prospective multicenter pilot study.

Integrative medicine research · 2026 · PMID 42088012

BACKGROUND: Long COVID, defined as symptoms persisting beyond 12 weeks after acute SARS-CoV-2 infection, has emerged as a significant global health concern. Fatigue is one of its most common and disabling symptoms, yet robust clinical evidence for effective treatments remains limited. METHODS: We conducted a multicenter, prospective, single-arm pilot study to evaluate the feasibility and potential effectiveness of Kyungok-go (Qiong-Yu-Gao), a traditional Korean herbal medicine, in individuals with Long COVID-relate…

Rank90.9
Randomized clinical study

COPANOS: use of gabapentin in the management of post-viral parosmia - a double-blind, randomised, placebo-controlled, multi-site trial - study protocol.

BMJ open · 2026 · PMID 42493204

INTRODUCTION: Parosmia is a qualitative olfactory disorder characterised by a distorted perception of smell, often experienced as unpleasant or offensive. Although parosmia has multiple aetiologies, post-viral parosmia has become increasingly prevalent following the COVID-19 pandemic. In the UK, post-viral parosmia affects an estimated 637 836 individuals and has a substantial negative impact on quality of life and mood. At present, there is no licensed or standardised treatment for this condition. Gabapentin, a ga…

Rank89.6
Randomized clinical study

ADDRESS-LC: study protocol for a phase 2, triple-blind, randomised, placebo-controlled trial to evaluate the efficacy and safety of bezisterim (NE3107) in adults with long COVID.

BMJ open · 2026 · PMID 42498469

INTRODUCTION: Long COVID is a debilitating condition consisting of prolonged neurological symptoms such as cognitive impairment ('brain fog') and sleep disturbance. Symptoms may be associated with ongoing neuroinflammation from the persistence of a viral reservoir, activation of other viruses, protracted macrophagic inflammatory memory or enduring viral Spike protein that stimulates proinflammatory cytokines via toll-like receptor (TLR) signalling. Bezisterim (NE3107) is an oral, blood-brain barrier-permeable, anti…

Rank85.0
Randomized clinical study

Diagnostic and clinical management of non-obstructive myocardial ischemia in patients with long Covid-19 syndrome and new-onset chest pain: Design and rationale of the long Covid-19 INOCA trial.

Cardiovascular revascularization medicine : including molecular interventions · 2026 · PMID 42538180

BACKGROUND: Beyond the respiratory symptoms of acute Infection from the SARS-CoV-2 virus, there is evidence that infection with the SARS-CoV-2 virus can cause many significant long-term effects, which are currently termed "Long Covid-19 syndrome (LCS)". Chest pain is one of the dominant symptoms of LCS. The exact mechanism of chest pain in LCS is not fully understood but can be potentially related to endothelial and myocardial cell injury caused by SARS-CoV-2 infection. METHODS: The Long Covid-19 INOCA trial is an …

Rank85.0
Randomized clinical study

Effectiveness of Brief Behavioral Intervention for Insomnia on Anxiety, Depression, Quality of Life, and Sleep: A Randomized Pilot Trial.

Cureus · 2026 · PMID 42534162

Introduction Sleep disorders and psychiatric diseases are public health problems that have increased due to the COVID-19 lockdown. In Mexico, telemedicine was a frequently used treatment modality under the circumstances of the lockdown. The present study aimed to test the effectiveness of brief behavioral intervention for improving symptoms of insomnia, anxiety, and depression and increasing quality of life in patients who survived the COVID-19 infection. Method A randomized, parallel-group equivalence clinical tri…

Rank85.0
Randomized clinical study

High-intensity interval training vs. moderate-intensity continuous training in COVID-19 survivors (COVIDEX): A randomized clinical trial on feasibility and short-term efficacy.

PM & R : the journal of injury, function, and rehabilitation · 2026 · PMID 42523063

BACKGROUND: High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have been widely studied in individuals with chronic conditions. However, no studies have compared these two exercise modalities in COVID-19 survivors. OBJECTIVE: To compare the feasibility, safety, adherence, and short-term efficacy of HIIT and MICT in improving functioning and health-related quality of life in COVID-19 survivors. DESIGN: Two-arm, parallel-group, single-center randomized clinical trial with a 1:1 …

Rank74.1
Multicenter clinical study

Anxiety and Depression Symptoms in ICU Survivors After COVID-19.

Nursing in critical care · 2026 · PMID 42429090

BACKGROUND: Post-intensive care syndrome includes physical, cognitive and psychological impairments that may persist after discharge from the intensive care unit (ICU), with anxiety and depression among the most commonly reported symptoms. Evidence on these symptoms beyond the first year after discharge remains limited, particularly in patients admitted for COVID-19. AIM: To determine the prevalence and characteristics of anxiety and depression symptoms among patients previously admitted to the ICU for COVID-19 wit…

Rank66.9
Observational or cohort study

PRECISE-DYAD: a prospective cohort study linking maternal and infant health trajectories in sub-Saharan Africa.

BMJ open · 2026 · PMID 42468953

PURPOSE: The PREgnancy Care Integrating Translational Science, Everywhere (PRECISE)-DYAD Study is a prospective observational cohort designed to investigate health outcomes among mother-child pairs (dyads) over the first 3 years of life in two contexts from sub-Saharan Africa. The primary objective of the study was to explore the effects of selected placenta-related complications, such as pregnancy hypertension, fetal growth restriction and preterm birth, on (1) Child health and development, and (2) Women's health …

Rank65.0
Prospective cohort studyResult signal: benefit

Individuals with Disabilities Receiving Care from a Program of All-Inclusive Care for the Elderly.

Archives of physical medicine and rehabilitation · 2026 · PMID 42498012

OBJECTIVE: To evaluate outcomes of the youngest eligible patients with disabilities enrolled in a Program of All Inclusive Care for the Elderly (PACE). HYPOTHESES: health (as defined by validated measures of function, mood, quality of life, and community engagement) and care-satisfaction (as defined by perception of care delivery) would improve after one year compared to baseline, and healthcare utilization would be similar to benchmarks from the National PACE Association. DESIGN: prospective cohort study SETTING: …

Rank63.7
Observational or cohort study

Subacute frontoinsular-cingulate tract changes in unvaccinated COVID-19 survivors: A tract-based spatial statistics study of diffusion tensor imaging.

Brain research bulletin · 2026 · PMID 42235760

BACKGROUND AND OBJECTIVES: Post-recovery brain changes following Coronavirus Disease 2019 (COVID-19) have been reported using various imaging techniques. The objective was to identify microstructural abnormalities between groups in specific fiber tracts using tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI), along with region-specific quantitative analysis of T1 relaxation times (qT1) and volumes. METHODS: This single-center, prospective, observational case-control study included adults ≥ 3 m…

Rank62.6
Observational or cohort study

Neurocognitive and psychological symptoms in post COVID-19 patients (PASC24): prospective cohort study protocol.

BMJ open · 2026 · PMID 42468962

INTRODUCTION: Knowledge about the late effects of COVID-19, or so-called post-acute sequelae of COVID (PASC), and its pathogenesis is still very limited. The purpose of this observational study is to chart late neurocognitive effects of the COVID-19 infection. The aim is to increase knowledge of the underlying biological processes and describe how biomarkers correlate with degree of symptoms, mapping their role as diagnostic markers over time (24 months). METHODS AND ANALYSIS: This prospective observational cohort …

Rank60.0
Observational or cohort study

Early mobilization during intensive care admission and perceived quality of life in the course of the COVID-19 pandemic - A prospective cohort study and propensity score matching.

Medicina intensiva · 2026 · PMID 41152078

OBJECTIVE: To analyze the effect of early physiotherapy (ePHYS) on patients' functional quality of life one year after discharge. DESIGN: Prospective observational study. SETTINGS: Adult polyvalent ICU. PATIENTS OR PARTICIPANTS: Patients with SARS-CoV2 pneumonia requiring invasive mechanical ventilation between March 2020 and July 2022. INTERVENTION: Early physiotherapy. MAIN VARIABLES OF INTEREST: Quality of life measured by CFS, Barthel and SF36 on ICU admission, at hospital discharge and one year after hospital …

Rank55.0
Other PubMed-indexed publication

Seasonality, Hospitalization, and Initiation of Home Dialysis: A Retrospective Cohort Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026 · PMID 42173345

RATIONALE & OBJECTIVE: Patients often initiate dialysis for end-stage kidney disease (ESKD) as inpatients, which may steer patients away from home dialysis. Because hospitalizations are often seasonal, this study examined whether inpatient initiation may contribute to the seasonality of home dialysis use. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: US adults with fee-for-service Medicare insurance who initiated dialysis between January 1, 2007, and November 30, 2020. EXPOSURE: Season of the ye…

Rank54.8
Other PubMed-indexed publicationResult signal: null

In-hospital outcomes of fibromyalgia patients undergoing primary total hip arthroplasty: a seven-year United States National Inpatient Sample propensity-matched analysis.

Scientific reports · 2026 · PMID 42463900

Fibromyalgia (FM) is a chronic nociplastic pain syndrome characterized by widespread pain, fatigue, and sensory amplification. While FM is linked to increased perioperative resource use and poorer patient-reported outcomes, its influence on in-hospital complications after total hip arthroplasty (THA) remains unclear. We analyzed the National Inpatient Sample (2016-2022) for adults undergoing elective primary THA for osteoarthritis. FM was defined as ICD-10-CM code M79.7. Exclusions included fracture, revision arthr…

Rank54.2
Other PubMed-indexed publication

Lessons from an early rheumatoid arthritis incident cohort.

Seminars in arthritis and rheumatism · 2026 · PMID 42247732

BACKGROUND: The Canadian Early Arthritis Cohort (CATCH) study, a pioneering national registry established in 2007, has generated robust real-world evidence that has significantly advanced early rheumatoid arthritis (ERA) care in Canada and internationally. METHODS: Data have been collected from over 3800 patients across 25 sites and >35,000 study visits. RESULTS: This paper synthesizes 15 key learnings from CATCH that span early diagnosis, treatment strategies, patient-reported outcomes, and health equity. Findings…

Rank52.8
Other PubMed-indexed publication

Real-World Evidence for the Impact of Minimal Disease Activity on Quality of Life in Atopic Dermatitis: An Interim Analysis of the Prospective, Multicenter, Non-Interventional UP-TAINED Study.

Dermatology and therapy · 2026 · PMID 42533213

INTRODUCTION: Minimal disease activity (MDA) has recently been introduced as comprehensive treatment target in atopic dermatitis (AD), integrating both clinician- and patient-reported outcomes. Evidence on the real-world feasibility and impact of achieving MDA on quality of life (QoL) remains limited. This analysis evaluated the association between MDA achievement and QoL outcomes in patients with moderate-to-severe AD receiving upadacitinib (UPA) in real-world clinical practice. METHODS: This interim analysis used…

Rank52.4
Other PubMed-indexed publication

Summary of Research: Cognition and Employment Status of People with Relapsing Multiple Sclerosis Treated with Cladribine Tablets: Two-Year CLARIFY-MS Study.

Neurology and therapy · 2026 · PMID 42271112

INTRODUCTION: Cognitive impairment is a common issue for people with multiple sclerosis (MS), affecting their daily lives and work. This study aimed to report the cognition and employment status of participants with highly active relapsing MS (RMS) treated with cladribine tablets (CladT) during the 2-year, open-label, single-arm, Phase 4 CLARIFY-MS study. METHODS: In this post hoc analyses, 482 participants with highly active RMS received at least one dose of CladT. Cognitive function was assessed using the Brief I…

Rank52.3
Other PubMed-indexed publication

Predictors for Anxiety and Stress in Long COVID: A Study in the Brazilian Population.

International journal of environmental research and public health · 2025 · PMID 40003484

Anxiety and stress are major challenges for public health and represent significant symptoms in long COVID. Despite the repercussions on quality of life and mental health, their impacts have not been systematically consolidated in the Brazilian population. Our objective was to analyze the indicators and predictors of anxiety and perceived stress in people who have experienced long COVID in different regional contexts in Brazil. This cross-sectional survey was carried out in the five regions of Brazil and included 4…

Randomized Controlled Trials70 records
Rank110.0
Systematic review or meta-analysis

Interventions to Enhance COVID-19 Pandemic Health Literacy in Health Professionals: Systematic Review.

JMIR medical education · 2026 · PMID 42430764

BACKGROUND: The COVID-19 pandemic has placed a significant burden on health professionals (HPs). They face higher infection risks due to the nature of their work environment and patient care responsibilities. Their ability to access and apply reliable COVID-19 information affects their own preventive behavior and that of those around them. In this context, health literacy (HL) has become increasingly important. Despite extensive research, information to foster COVID-19-related HL in HPs remains limited. OBJECTIVE: …

Rank108.5
Systematic review or meta-analysisResult signal: null

Pharmacological thromboprophylaxis in hospitalized patients with acute infectious diseases: a meta-analysis.

European journal of clinical pharmacology · 2026 · PMID 42479201

INTRODUCTION: Venous thromboembolism (VTE) may be a significant complication in medical patients, and infectious disease has been highlighted as an additional risk factor. Pharmacological thromboprophylaxis can prevent VTE and is recommended in at-risk populations, but not routinely in patients with infectious diseases. METHODS: We conducted a systematic review and meta-analysis of studies on the effectiveness of pharmacological thromboprophylaxis in patients with acute infections, excluding those involving COVID-1…

Rank107.3
Systematic review or meta-analysisResult signal: null

Low-dose corticosteroids in severe pulmonary infection: a meta-analysis of randomised controlled trials.

BMJ open respiratory research · 2026 · PMID 42425738

PURPOSE: Pulmonary infections are one of the leading causes of intensive care unit (ICU) admission and contribute to high mortality rates. This paper aimed to determine the effect of low-dose corticosteroids on outcomes in patients with severe pulmonary infections, including coronavirus disease of 2019, community-acquired pneumonia (CAP), pneumocystis pneumonia, sepsis, septic shock, and acute respiratory distress syndrome. METHODS: We systematically reviewed randomised controlled trials (RCTs) comparing low-dose c…

Rank106.7
Systematic review or meta-analysis

Respiratory Support in the Emergency Department: An Updated Systematic Review and Meta-Analysis.

Worldviews on evidence-based nursing · 2026 · PMID 42410869

BACKGROUND: An estimated 20% of emergency department (ED) patients require respiratory support (RS). Evidence suggests that nasal high flow (NHF) reduces RS need. AIMS: This is an update of a published review comparing NHF to non-invasive ventilation (NIV) or to conventional oxygen therapy (COT) in adult ED patients. METHOD: This updated systematic review (SR) and meta-analysis (MA) methods reflect the Cochrane Collaboration's methodology. The search of six databases was first completed in July 2023 and then repeat…

Rank106.6
Systematic review or meta-analysisResult signal: null

The effect of high-dose of vitamin C on mortality among aged patients with severe COVID-19: A systematic review and meta-analysis.

Clinical and investigative medicine. Medecine clinique et experimentale · 2026 · PMID 42446912

BACKGROUND: Critically ill patients are frequently deficient in vitamin C. Given the significant mortality rates in the elderly population associated with COVID-19, we aimed to systematically review the literature and evaluate whether high-dose vitamin C can reduce COVID-19 mortality in this population. METHODS: Multiple data sources (PubMed, Web of Science, ScienceDirect, and medRxiv) were searched using the keywords "COVID-19" AND "vitamin C" up to November 2024. Randomized controlled trials (RCTs) involving COVI…

Rank106.4
Systematic review or meta-analysis

Effect of low-dose naltrexone for long COVID: a systematic review and meta-analysis.

BMJ open · 2026 · PMID 42463201

OBJECTIVE: Long covid is a debilitating chronic condition, and the effect of low-dose naltrexone (LDN) on its symptoms is unclear. We aimed to determine the effectiveness of LDN on symptoms of long covid. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase and Cochrane Library for published studies; ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) for registered ongoing studies were searched through 5 May 2026. ELIGIBILITY CRITERIA: We included randomised cont…

Rank103.6
Systematic review or meta-analysis

Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients.

Journal of the American College of Cardiology · 2026 · PMID 42523015

BACKGROUND: Public health emergencies require rapid generation, synthesis, and translation of clinical evidence into practice guidelines; yet, systematic synthesis of the challenges and lessons from these processes remains limited. OBJECTIVES: The purpose of this study was to examine how evidence on anticoagulation in COVID-19 was generated and translated into clinical guidance, using randomized controlled trials (RCTs) as a case study, and to contextualize these processes with an individual participant data meta-a…

Rank102.6
Systematic review or meta-analysis

Effect of Pentoxifylline on Inflammatory Markers in COVID-19: A Meta-Analysis of Randomized Controlled Trials.

Viral immunology · 2026 · PMID 42159324

The hyperinflammatory response in COVID-19 is a major factor contributing to morbidity. Pentoxifylline, a methylxanthine derivative, has immunomodulatory properties, but its effects on inflammatory markers in COVID-19 remain unclear. This meta-analysis aims to evaluate the efficacy of pentoxifylline supplementation on CRP and interleukin-6 (IL-6) levels in these patients. A systematic search was conducted across multiple databases for randomized controlled trials (RCTs) published up to September 2025. Four RCTs, in…

Rank100.5
Randomized controlled trial

Multivitamin supplementation and COVID-19 incidence and symptom severity in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized trial.

The American journal of clinical nutrition · 2026 · PMID 42385272

BACKGROUND: The effect of long-term daily multivitamin-mineral (MVM) supplementation on Coronavirus Disease 2019 (COVID-19) prevention and symptom severity remains unclear. OBJECTIVES: We tested the hypothesis that a daily MVM reduced COVID-19 incidence or symptom severity among generally healthy older adults. METHODS: We conducted a secondary analysis in the COcoa Supplement and Multivitamin Outcomes Study, a randomized, double-blinded, placebo-controlled trial (June 2015 to December 2020), evaluating daily MVM an…

Rank100.0
Systematic review or meta-analysis

Approaches to observational study designs and analytical options to evaluate the safety of multi-dose vaccines: a systematic review.

Expert review of vaccines · 2026 · PMID 42057741

INTRODUCTION: Observational studies require careful considerations when evaluating the safety of multidose vaccines. We reviewed design and analytical approaches in observational studies evaluating the safety of multidose vaccines in the post-licensure phase. METHODS: EMBASE, MEDLINE, Web of Science, and Scopus (2018-2022) were searched for hypothesis-testing studies evaluating the safety of multidose vaccines. Key features from frequently used designs were extracted. RESULTS: Among 123 eligible studies, cohort (46…

Rank100.0
Randomized controlled trial

Immune correlates analysis in NextCOVE trial for a next-generation mRNA-1283 COVID-19 vaccine.

Human vaccines & immunotherapeutics · 2026 · PMID 42220116

SARS-CoV-2 neutralizing antibodies (nAbs) are strongly inversely associated with COVID-19 risk and have correlated with vaccine efficacy across multiple clinical trials conducted during the COVID-19 pandemic. As SARS-CoV-2 continues to evolve in the endemic era, it is important to determine whether nAb levels remain a valid statistical correlate of protection and potential surrogate endpoints for emerging variants. The next-generation COVID-19 vaccine, mRNA-1283, has recently received regulatory approval worldwide.…

Rank100.0
Systematic review or meta-analysis

SPECT/CT Scan Images to Evaluate COVID-19 Pulmonary Complications: A Systematic Review.

International journal of environmental research and public health · 2025 · PMID 40003533

INTRODUCTION: The highly contagious 2019 novel coronavirus that causes coronavirus disease 2019 increased the scientific community's interest in diagnosing and monitoring COVID-19. Due to the findings about the association between COVID-19 infection and pulmonary disturbances, the need for the use of complementary tests that can be carried out, preserving the health of patients, has grown. In this context, single-photon emission computed tomography (SPECT) was performed during the COVID-19 pandemic to assess and tr…

Rank99.9
Randomized controlled trial

Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial.

Nature communications · 2026 · PMID 42533000

Persistent cardiac symptoms are common in post-COVID syndrome, even without structural heart disease. Evidence implicates immune dysregulation, endothelial dysfunction and low-grade cardiovascular inflammation. Yet no targeted treatment exists. Myoflame-19 is a multicenter, double-blind clinical trial of 279 participants with inflammatory cardiac involvement defined by cardiovascular magnetic resonance, randomized 1:1 to losartan plus prednisolone (n = 139) or matching placebos (n = 140) for 16 weeks. The modified …

Rank99.5
Randomized controlled trialResult signal: null

Ensitrelvir for the Treatment of Hospitalized Adults With COVID-19: An International Phase 3 Randomized Placebo-controlled Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 42017206

BACKGROUND: Antivirals remain an important treatment strategy for persons who experience severe and life-threatening COVID-19. Ensitrelvir is an oral 3CL protease inhibitor with potent antiviral activity. METHODS: We conducted an international randomized, placebo-controlled trial of ensitrelvir with standard of care (SOC) among adults hospitalized for COVID-19. The primary outcome was clinical recovery assessed by the days to recovery scale through day 60 (DRS-60), analyzed using a Van Elteren test. RESULTS: From 2…

Rank98.9
Randomized controlled trial

Cognitive Rehabilitation and Functional Outcomes in Long COVID-Related Cognitive Impairment: A Randomized Clinical Trial.

JAMA network open · 2026 · PMID 42384384

IMPORTANCE: Cognitive impairment is common in long COVID and severely affects daily life, with no proven treatments to date. OBJECTIVE: To evaluate the ability of cognitive rehabilitation (CR) to improve goal attainment, cognitive, and clinical outcomes in individuals with cognitive impairment as part of long COVID. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, single-blind, 2-arm, parallel-group randomized clinical trial was conducted at 3 sites in England between February 2023 and March 2024. Participants …

Rank98.1
Randomized controlled trial

Effectiveness of the school-based internet intervention StresSOS for the prevention of mental health problems in young people: a randomized controlled trial as part of the ProHEAD consortium.

Journal of child psychology and psychiatry, and allied disciplines · 2026 · PMID 41821499

BACKGROUND: Given the high prevalence of mental illnesses in adolescents, there is an urgent need for effective prevention strategies. The aim of this study was to evaluate the school-based internet intervention StresSOS for the universal prevention of mental illnesses in youth. METHODS: A two-arm, randomized controlled trial was conducted. Participants were recruited from schools across five regions of Germany. Young people between the ages of 12 and 25 years without mental health problems were invited to the tria…

Rank98.1
Randomized controlled trial

Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial.

Lancet (London, England) · 2026 · PMID 42442374

BACKGROUND: Latin America faces a high dementia burden, with increased prevalence of factors associated with cognitive decline. Multidomain lifestyle interventions might delay cognitive decline, but populations from Latin America remain under-represented in dementia prevention trials. We aimed to investigate the feasibility of a culturally adapted, multidomain, systematic lifestyle intervention and investigate its effects on global cognitive function in at-risk older adults (aged 60-77 years). METHODS: The LatAm-FI…

Rank98.0
Randomized controlled trial

Comparing the Antimicrobial Resistance Crisis to the COVID-19 Pandemic: A Randomized Public Health Messaging Experiment.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41964533

BACKGROUND: Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the coronavirus disease 2019 (COVID-19) pandemic could enhance public understanding of AMR and reduce intentions to seek unnecessary antibiotics. METHODS: In this randomized online survey (March-April 2024), US adults were randomized to receive 1 of 3 messages: (1) written message des…

Rank97.6
Randomized controlled trial

Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Randomized Clinical Trial.

JAMA internal medicine · 2025 · PMID 39804633

IMPORTANCE: The optimal configuration of a smoking cessation intervention in a lung cancer screening (LCS) setting has not yet been established. OBJECTIVE: To evaluate the efficacy of 3 tobacco treatment strategies of increasing integration and intensity in the LCS setting. DESIGN, SETTING, AND PARTICIPANTS: In this randomized clinical trial, LCS-eligible current smokers were randomized into 3 treatments: quitline (QL), QL plus (QL+), or integrated care (IC). The study was conducted from July 2017 to June 2022 at a…

Rank97.6
Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.5
Randomized controlled trial

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

Human vaccines & immunotherapeutics · 2026 · PMID 41627968

A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase 1/2 clinical trial. This stratified, observer-blinded study randomly assigned healthy adults (18-75 years) to receive mRNA-1073 (25-µg, 50-µg, or 100-µg) + placebo, mRNA-1…

Rank97.5
Randomized controlled trial

Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study).

Gut microbes · 2026 · PMID 42520140

BACKGROUND: Although COVID-19 vaccination has reduced morbidity and mortality, adults aged 65 y old and older are at high risk of complications from COVID-19. The evidence suggests that probiotics may enhance immune responses when co-administered with influenza vaccination. However, few studies have evaluated the potential benefit of probiotic supplementation in this context in this high-risk population. MATERIAL: This study was a randomized controlled trial recruiting adults between 65 and 89 y of age living in Qu…

Rank97.2
Randomized controlled trial

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy · 2026 · PMID 42241901

BACKGROUND: During the COVID-19 pandemic, Mesenchymal Stromal Cells (MSCs) were rapidly proposed as a therapeutic option for Acute Respiratory Distress Syndrome (ARDS) based on their immunomodulatory properties. We report the results of COVIDMES, a multicenter trial initiated within a public blood and tissue bank infrastructure during unprecedented period of volatility and scientific uncertainty of the first pandemic waves. AIMS: To evaluate the safety, feasibility and exploratory efficacy of Wharton's Jelly-derive…

Rank97.0
Randomized controlled trial

Price Discounts to Promote Supermarket Fruit, Vegetable, and Noncaloric Beverage Intake and Health Outcomes: A Randomized Controlled Trial.

Journal of the Academy of Nutrition and Dietetics · 2026 · PMID 41905413

BACKGROUND: Despite the well-known health benefits of fruit and vegetable (FV) intake, dietary quality among Americans remains low. Barriers to healthy food intake, such as cost, may contribute to suboptimal FV intake. OBJECTIVE: The aim of this study was to assess the effects of multi-level supermarket price discounts of 30%, 15%, or 0% (control) on fruits, vegetables, and noncaloric beverages (NCB) on FV and NCB intake and health outcomes. DESIGN: In this randomized controlled trial (RCT), Multi-level Supermarket…

Rank96.9
Randomized controlled trial

Evaluating a Tailored Web-Based eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic: Randomized Clinical Trial.

Journal of medical Internet research · 2026 · PMID 42430132

BACKGROUND: Prostate cancer (PCa) is the most common nonskin cancer among men. Although treatments achieve excellent survival for localized PCa, long-lasting complications significantly diminish patients' quality of life (QOL) across physical, sexual, psychosocial, and general symptom domains. Because these effects also profoundly impact intimate partners, often reducing partners' QOL as much as or more than patients' QOL, supportive care must address the needs of both members of the couple. OBJECTIVE: This study e…

Safety And Adverse Effects108 records
Rank102.0
Systematic review or meta-analysis

Impact of COVID-19 on the Development of Femoral Head Avascular Necrosis: A Systematic Review.

Medical sciences (Basel, Switzerland) · 2026 · PMID 42506341

BACKGROUND: COVID-19 has been linked to musculoskeletal complications, including femoral head avascular necrosis (AVN). Both COVID-19-related hypercoagulability and corticosteroid therapy have been proposed as contributing factors. This systematic review synthesizes current evidence on the occurrence, clinical characteristics, timing, and risk factors for femoral head AVN following COVID-19. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, and Scopus identified observational studies and case series …

Rank100.0
Systematic review or meta-analysis

No fault vaccine injury compensation after COVID-19: A systematic literature review and proposed typology.

Human vaccines & immunotherapeutics · 2026 · PMID 41630128

The COVID-19 pandemic brought about a unique and rapid period of global vaccine innovation. It revealed structural challenges not only in global vaccine affordability and distribution but in the liability and indemnity structures that can both impede access and affect fair outcomes for the small number of people who suffer severe side effects. This review examines vaccine injury and compensation mechanisms, including no-fault compensation schemes, aimed at addressing both the liability and indemnity concerns of dev…

Rank100.0
Systematic review or meta-analysis

Autoimmunity following SARS-CoV-2 infection and vaccination: Systematic review and meta-analysis.

Clinical immunology (Orlando, Fla.) · 2026 · PMID 41905519

AIM: To systematically review and meta-analyze the available evidence on the association between SARS-CoV-2 infection, COVID-19 vaccination, and the development of new autoimmune conditions (AIC). METHODS: This study followed the PRISMA guidelines. MEDLINE, Scopus, Cochrane Library, and Google Scholar were searched until December 31, 2024, for studies reporting new-onset autoimmunity after SARS-CoV-2 infection or vaccination. Meta-analyses using random-effects models calculated pooled odds ratios using RStudio 4.3.…

Rank100.0
Systematic review or meta-analysis

Approaches to observational study designs and analytical options to evaluate the safety of multi-dose vaccines: a systematic review.

Expert review of vaccines · 2026 · PMID 42057741

INTRODUCTION: Observational studies require careful considerations when evaluating the safety of multidose vaccines. We reviewed design and analytical approaches in observational studies evaluating the safety of multidose vaccines in the post-licensure phase. METHODS: EMBASE, MEDLINE, Web of Science, and Scopus (2018-2022) were searched for hypothesis-testing studies evaluating the safety of multidose vaccines. Key features from frequently used designs were extracted. RESULTS: Among 123 eligible studies, cohort (46…

Rank100.0
Systematic review or meta-analysis

SPECT/CT Scan Images to Evaluate COVID-19 Pulmonary Complications: A Systematic Review.

International journal of environmental research and public health · 2025 · PMID 40003533

INTRODUCTION: The highly contagious 2019 novel coronavirus that causes coronavirus disease 2019 increased the scientific community's interest in diagnosing and monitoring COVID-19. Due to the findings about the association between COVID-19 infection and pulmonary disturbances, the need for the use of complementary tests that can be carried out, preserving the health of patients, has grown. In this context, single-photon emission computed tomography (SPECT) was performed during the COVID-19 pandemic to assess and tr…

Rank98.1
Randomized controlled trial

Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial.

Lancet (London, England) · 2026 · PMID 42442374

BACKGROUND: Latin America faces a high dementia burden, with increased prevalence of factors associated with cognitive decline. Multidomain lifestyle interventions might delay cognitive decline, but populations from Latin America remain under-represented in dementia prevention trials. We aimed to investigate the feasibility of a culturally adapted, multidomain, systematic lifestyle intervention and investigate its effects on global cognitive function in at-risk older adults (aged 60-77 years). METHODS: The LatAm-FI…

Rank97.6
Randomized controlled trial

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42390526

Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike (rS) to the ancestral strain (Wuhan) and quadrivalent influenza hemagglutinin with a Matrix-M® saponin-based adjuvant were evaluated in a phase 1/2 blinded, randomized trial. The safety, t…

Rank97.5
Randomized controlled trial

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

Human vaccines & immunotherapeutics · 2026 · PMID 41627968

A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase 1/2 clinical trial. This stratified, observer-blinded study randomly assigned healthy adults (18-75 years) to receive mRNA-1073 (25-µg, 50-µg, or 100-µg) + placebo, mRNA-1…

Rank96.0
Randomized controlled trialResult signal: null

A Randomised Controlled Trial Testing a Behavioural Intervention Program for the Prevention of Type 2 Diabetes Among American Indian Youth: The Tribal Turning Point Study.

Pediatric obesity · 2025 · PMID 40884258

BACKGROUND: American Indian youth experience a high risk of overweight/obesity and type 2 diabetes. OBJECTIVES: To evaluate the effect of a behavioural intervention on diabetes risk factors among American Indian youth with overweight/obesity. METHODS: Between 2018 and 2023, youth (7-10 years) were randomised to the tribal turning point (TTP) intervention (n = 87) or control arm (n = 95). Community coaches delivered the core intervention in the first 6 months (10 group classes, 4 individual sessions with motivationa…

Rank96.0
Systematic review or meta-analysis

Effectiveness, Safety, and Immunogenicity of a Second COVID-19 Vaccine Booster in the Elderly: A Systematic Review and Meta-Analysis Protocol.

Health science reports · 2026 · PMID 42524361

BACKGROUND/AIMS: Older adults remain highly vulnerable to severe COVID-19 outcomes due to immunosenescence and comorbidities. Although booster vaccination strategies have reduced hospitalizations and mortality, evidence regarding the effectiveness, safety, and immunogenicity of a second COVID-19 vaccine booster dose in older adults remains fragmented. This systematic review and meta-analysis protocol aims to critically evaluate the available evidence from randomized and nonrandomized clinical trials (NRCTs) regardi…

Rank96.0
Systematic review or meta-analysis

Telemedicine in pediatrics: a critical narrative review of innovations, limitations, and future priorities.

European journal of pediatrics · 2026 · PMID 42541600

UNLABELLED: This narrative review synthesizes recent technological and organizational developments in pediatric telemedicine, maps their principal clinical applications, and critically discusses implementation, safety, equity, and future priorities. This narrative review used a transparent, non-systematic literature-search approach in PubMed/MEDLINE, Scopus, and Google Scholar, considering publications available through April 2026. Searches were intended to identify and contextualize relevant literature across pedi…

Rank95.2
Randomized controlled trial

Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas.

The New England journal of medicine · 2026 · PMID 42341302

BACKGROUND: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is a standard treatment for relapsed or refractory B-cell non-Hodgkin lymphomas. Long-term results and curative potential remain uncertain. METHODS: We evaluated long-term outcomes in 38 patients with relapsed or refractory B-cell non-Hodgkin lymphomas (24 patients with large B-cell lymphoma and 14 with follicular lymphoma) who had been treated with CTL019 (now called tisagenlecleucel) - autologous T cells expressing CD19-directed, 4-1BB-costimula…

Rank95.0
Phase III clinical trial

Safety evaluation of the single-dose Ad26.COV2.S vaccine among healthcare workers in the Sisonke study in South Africa: A phase 3b implementation trial.

PLoS medicine · 2022 · PMID 35727802

BACKGROUND: Real-world evaluation of the safety profile of vaccines after licensure is crucial to accurately characterise safety beyond clinical trials, support continued use, and thereby improve public confidence. The Sisonke study aimed to assess the safety and effectiveness of the Janssen Ad26.COV2.S vaccine among healthcare workers (HCWs) in South Africa. Here, we present the safety data. METHODS AND FINDINGS: In this open-label phase 3b implementation study among all eligible HCWs in South Africa registered in…

Rank92.0
Randomized controlled trial

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026 · PMID 42420160

OBJECTIVES: The PRIME randomized trial demonstrated improved neonatal outcomes using biomarker-guided risk stratification to target interventions to pregnancies at higher risk of preterm birth (PTB). This subgroup analysis evaluated its effectiveness in nulliparous pregnancies, a population with higher baseline risk and limited obstetric history to inform risk assessment. METHODS: PRIME (NCT04301518) was a 19‑center randomized controlled trial evaluating a screen‑guided care strategy using the IGFBP4/SHBG biomarker…

Rank92.0
Randomized controlled trial

Safety and immunogenicity of diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed after three-dose priming in 2 months age infants: a randomized, blinded, controlled phase III clinical trial in China.

Emerging microbes & infections · 2026 · PMID 41615771

Pertussis remains a leading cause of infant mortality globally, with rising cases in China post-COVID-19. Despite vaccination, waning immunity from acellular pertussis vaccines has driven resurgence. We evaluated a novel diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed (DTcP), China's first genetically engineered three-component pertussis vaccine, administered under two primary schedules (2/3/4 vs. 2/4/6 months) compared to licensed DTaP-IPV-Hib (Pentaxim). In this randomiz…

Rank92.0
Randomized controlled trial

Safety and immunogenicity of a booster dose of COVAC-2, a Sepivac SWE™ adjuvanted SARS-CoV-2 recombinant protein vaccine in previously vaccinated healthy adults; a randomized controlled multicentre trial.

Human vaccines & immunotherapeutics · 2026 · PMID 42268674

This Phase 1 clinical trial evaluated the safety and immunogenicity of COVAC-2, a recombinant protein subunit vaccine as a heterologous booster in adults previously immunized with authorized COVID-19 vaccines (NCT05226702). COVAC-2 contains the SARS-CoV-2 S1 spike protein subunit adjuvanted with Sepivac SWE™, an open-access oil-in-water adjuvant. Sixty participants were randomized to receive a single intramuscular dose of COVAC-2 (10 µg or 25 µg) or placebo, with follow-up through Day 180. The vaccine was well tole…

Rank92.0
Randomized controlled trial

Safety and durability of influenza and SARS-CoV-2 antibody responses through 6 months after a single dose of mRNA-1083, a multicomponent influenza and COVID-19 vaccine, in adults ≥50 years.

Human vaccines & immunotherapeutics · 2026 · PMID 42213900

Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2. In this phase 3, observer-blind, active-controlled trial (NCT06097273), adults (aged ≥50 y) were randomly assigned (1:1) to receive mRNA-1083 (40 µg; plus placebo) or age-appropriate licensed comparator vaccines for influenza and COVID-19. Two substudies were included: Cohort A (≥65 y) and Cohort B (50-64 y)…

Rank87.2
Randomized clinical study

A Randomized, Double-Blind, Placebo-Controlled Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Outer Membrane Vesicle (OMV) Platform-Based Vaccine Administered Intranasally to Healthy Adults.

Vaccines · 2026 · PMID 42506612

Background: The COVID-19 pandemic exposed critical gaps in pandemic preparedness and highlighted the need for vaccine platforms capable of rapid adaptation. Outer membrane vesicle (OMV)-based platforms utilizing vesicles derived from genetically detoxified Neisseria meningitidis serogroup B (Nm-nOMV) represent a promising plug-and-play approach. Methods: This Phase I, first-in-human, randomized, double-blind, placebo- and OMV-controlled trial, evaluated safety, tolerability, and immunogenicity of intranasally admin…

Rank87.0
Randomized clinical study

Demographics, Services, and Practices in Attention-Deficit/Hyperactivity Disorder Coaching in the US.

JAMA network open · 2026 · PMID 41538184

IMPORTANCE: Individuals with ADHD face great challenges accessing formal psychosocial treatment. ADHD coaching has rapidly emerged online as a popular and accessible form of grassroots psychosocial support; however, there is a paucity of documentation about this workforce or the safety and effectiveness of its services. OBJECTIVE: To document patterns in the ADHD coaching workforce, including workforce entry dates, services, and coach characteristics. DESIGN, SETTING, AND PARTICIPANTS: The US National Survey on ADH…

Rank85.0
Randomized clinical study

Modeling the cost-effectiveness of the next-generation COVID-19 mRNA-1283 vaccine in the United States.

Journal of medical economics · 2026 · PMID 41764030

AIMS: COVID-19 disease burden in United States (US) adults ≥65 years and persons with underlying medical conditions remains high. This modeling study estimated the cost-effectiveness of the next-generation COVID-19 mRNA-1283 vaccine in persons aged 12-64 at high risk of severe COVID-19 outcomes and all adults ≥65 years. METHODS: mRNA-1283 was compared with no annual vaccination and originally licensed mRNA vaccines mRNA-1273 and BNT162b2. Analyses were conducted using a static decision-analytic model (1-year horizo…

Rank82.3
Phase II clinical trial

Lucinactant, a Synthetic Surfactant for the Treatment of Acute Respiratory Distress Syndrome Caused by COVID-19: Phase 1/2A Trial.

JMIR formative research · 2026 · PMID 42536986

BACKGROUND: One unique feature of COVID-19-associated acute respiratory distress syndrome (ARDS) is surfactant deficiency because SARS-CoV-2 specifically attacks alveolar type 2 cells. OBJECTIVE: In this study, we evaluated the effects of a synthetic surfactant (lucinactant) therapy in patients with COVID-19-associated ARDS. METHODS: This open-label multicenter phase 1/2A trial enrolled adult patients with COVID-19-associated ARDS who were within 7 days of mechanical ventilation initiation. Lucinactant (160 mL or a…

Rank78.2
Multicenter clinical study

Impact of Age on Bleeding, Stroke, and Mortality in Edoxaban-Treated Patients with Atrial Fibrillation: Results from the ETAF-TR Registry.

Drugs & aging · 2026 · PMID 42455491

BACKGROUND: Data on age-specific outcomes in patients with atrial fibrillation (AF) treated with edoxaban in real-world settings are limited; this prespecified analysis of the ETAF-TR study aimed to investigate the influence of age on prespecified clinical outcomes, including overt bleeding, major bleeding, ischemic stroke, all-cause mortality, major adverse cardiovascular events (MACE), and net clinical benefit. METHODS: The ETAF-TR study is a prospective, multicenter, observational registry conducted at 50 cardio…

Rank75.9
Multicenter clinical studyResult signal: harm

High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

Journal of critical care · 2026 · PMID 42385526

BACKGROUND: Optimal corticosteroid dosing strategies remain unclear for severe coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU). This study compared mortality among patients treated with high-dose versus standard-dose corticosteroids. METHODS: This prospective cohort study included adult patients with COVID-19 ARDS, defined according to Berlin criteria for ARDS, across 22 centers in the Netherlands between March 2020 and January 2021. Mortality hazards were compared between pat…

Rank73.0
Multicenter clinical study

The impact of pediatric influenza and COVID-19 hospitalization on parental attitudes toward vaccination.

Human vaccines & immunotherapeutics · 2026 · PMID 42246636

Hospitalization for vaccine-preventable infections may influence parental vaccination attitudes, but comparative data for influenza and COVID-19 are limited. We conducted a multicenter observational study of unvaccinated children hospitalized with influenza or COVID-19 in Poland. We collected clinical data and parental survey data assessing vaccination regret, future vaccination intentions, willingness to encourage others, interest in vaccination reminders, reasons for non-vaccination, and sources of influence. Par…

Rank70.9
Prospective cohort studyResult signal: harm

Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network.

Human vaccines & immunotherapeutics · 2026 · PMID 42053343

Safety data on COVID-19 and influenza vaccination in immunocompromised and/or autoimmune pediatric populations remains limited. This study evaluated post-vaccination health events in this vulnerable population using active surveillance data from the Canadian National Vaccine Safety (CANVAS) Network. A prospective cohort of participants aged 6 months to 19 y, who self-identified with an autoimmune and/or immunocompromised condition, were followed across several Canadian provinces (2023-2025). Participants were vacci…

Treatments That Failed Clinical Trials61 records
Rank101.3
Randomized controlled trialResult signal: harm

Adenovirus type 5 vector-based COVID-19 vaccine does not increase the likelihood of HIV infection.

Vaccine · 2026 · PMID 41785679

BACKGROUND: There is a concern about the potential increased risk of acquiring HIV infection after vaccination with adenovirus type 5 (Ad5) vector-based vaccines. We aimed to investigate whether Ad5-nCoV increases the risk of HIV infection. METHODS: Between September 2020 and March 2021, a Phase 3 clinical trial was executed to evaluate the efficacy of Ad5-nCoV. This trial, employing a double-blind, randomized, and placebo-controlled design, enrolled 44,247 participants from 66 clinical sites spanning Argentina, Ch…

Rank99.3
Randomized controlled trialResult signal: null

Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial.

Implementation science : IS · 2026 · PMID 42098760

BACKGROUND: "Nudges" embedded in the electronic health record (EHR) facilitate desired decisions while preserving autonomy and may provide a scalable strategy to overcome the common implementation barrier of lack of knowledge about a best practice. We sought to test whether EHR-based nudges targeting two intensive care unit (ICU) clinician groups would safely increase evidence-based use of low tidal volume ventilation. METHODS: We performed a stepped-wedge, cluster randomized, hybrid type 3 effectiveness-implementa…

Rank99.0
Randomized controlled trialResult signal: null

Personal household air pollution exposure and SARS-CoV-2 antibody responses among women and infants: an analysis within the HAPIN trial.

Environment international · 2026 · PMID 41875666

BACKGROUND: While extensive research has linked ambient air pollution to increased COVID-19 infection rates and severity, the role of household air pollution-a major public health exposure affecting nearly 3 billion people globally-remains understudied. Here, we evaluate associations between a clean cooking intervention, personal household air pollution exposure, and serologic evidence of prior SARS-CoV-2 infection using exploratory intention-to-treat and exposure-response analyses. METHODS: The Household Air Pollu…

Rank98.6
Randomized controlled trialResult signal: null

Impact of eccentric exercise on walking functional capacity after severe COVID-19: randomized, controlled open-label trial.

Annals of physical and rehabilitation medicine · 2026 · PMID 42019312

INTRODUCTION: Severe COVID-19 infection leads to profound pulmonary, cardiovascular, and neuromuscular impairments, resulting in marked exercise deconditioning and reduced functional walking capacity after hospital discharge. Eccentric cycling offers high mechanical load with low metabolic cost and may therefore represent a relevant rehabilitation strategy to restore functional capacity in people after COVID-19. AIM: To compare functional recovery after 8 weeks of eccentric (ECC) or concentric (CON) training in ind…

Rank98.0
Randomized controlled trial

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42370465

BACKGROUND: Despite the relative success of immuno-modulatory disease-modifying therapy in relapsing remitting multiple sclerosis, progressive worsening of disability remains a major problem, particularly for those with secondary progressive multiple sclerosis. Various underlying mechanisms are likely to contribute, augmented by comorbidities (such as vascular risk) and ageing. In the phase 2b MS-STAT trial, simvastatin (80 mg) (Sandoz Ltd, Camberley, UK) reduced the mean annualised whole brain atrophy rate by 43% …

Rank98.0
Randomized controlled trial

Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts.

The New England journal of medicine · 2026 · PMID 42127390

BACKGROUND: Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 (Covid-19). Previously, no antiviral agents were approved for postexposure prophylaxis in household contacts of patients with Covid-19. METHODS: In this double-blind, randomized, placebo-controlled trial, we randomly assigned persons who were SARS-CoV-2-negative on local diagnostic testing but were household c…

Rank97.8
Randomized controlled trialResult signal: harm

Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.

Social psychiatry and psychiatric epidemiology · 2026 · PMID 39251412

BACKGROUND: Social participation as a protective factor against cognitive decline was one of the targets in the AgeWell.de study, a multi-domain interventional trial in a sample of older adults at increased risk for dementia. This study aimed to examine differential effects of the intervention and other influencing factors on social participation throughout the trial. METHODS: A longitudinal analysis of study data at the primary follow-up after 24 months (n = 819) was conducted. The Lubben Social Network Scale (LSN…

Rank97.6
Randomized controlled trialResult signal: null

Evaluating the effectiveness of a telemedicine-based STEADI implementation in primary care on fall outcomes: the STEADI options randomized controlled trial.

The Gerontologist · 2026 · PMID 41349283

BACKGROUND AND OBJECTIVES: Falls are a leading cause of injury and death among older adults (65 years and above). The Centers for Disease Control and Prevention's Stopping Elderly Accident, Deaths, and Injuries (STEADI) initiative aims to reduce falls by screening to find at-risk individuals, evaluation, and then addressing modifiable risk factors. This study evaluated the effectiveness of implementing a STEADI-based multi-component fall prevention approach via telemedicine in primary care. RESEARCH DESIGN AND METH…

Rank97.3
Randomized controlled trialResult signal: null

Assessing a facilitated social network intervention for health outcomes in lonely and socially isolated people: the pragmatic, cluster-randomized PALS trial.

Frontiers in public health · 2026 · PMID 41982893

INTRODUCTION: Loneliness has received attention in recent years as an important public health issue due to its associations with poorer mental and physical health. This study aimed to assess the effectiveness and cost-effectiveness of a facilitated social network intervention to alleviate loneliness and social isolation in community settings. METHODS: A pragmatic, cluster-randomized controlled trial (RCT) was conducted to compare participants receiving the intervention with a wait-list control group. This trial als…

Rank97.2
Randomized controlled trial

The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.

Annals of internal medicine · 2026 · PMID 41911553

BACKGROUND: Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom. OBJECTIVE: To assess the efficacy of fluvoxamine and metformin for long COVID fatigue. DESIGN: Randomized, placebo-controlled, adaptive trial. (ClinicalTrials.gov: NCT06128967). SETTING: Outpatient sites in Brazil. PARTICIPANTS: 399 adults with fatigue persisting 90 or more days after confirmed SARS-CoV-2 infection. INTERVENTION: Participants were randomly ass…

Rank97.2
Randomized controlled trialResult signal: null

Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.

Health technology assessment (Winchester, England) · 2026 · PMID 42153520

BACKGROUND: HomeHealth is a home-based, voluntary sector service supporting older people with mild frailty to maintain independence through behaviour change. Support workers discuss the person's priorities and enable setting/achieving goals around mobility, nutrition, socialising and/or psychological well-being. AIMS: We tested clinical and cost-effectiveness of HomeHealth for maintaining independence in older people with mild frailty in a randomised controlled trial. METHODS: Design: Single-blind, parallel randomi…

Rank97.2
Randomized controlled trialResult signal: benefit

Effects of inspiratory muscle training on exercise capacity, muscle oxygenation and strength, physical activity, and dyspnea in patients with post-COVID-19 syndrome and pulmonary involvement: a randomized controlled triple-blinded study.

BMC pulmonary medicine · 2026 · PMID 41906071

BACKGROUND: Coronavirus disease 2019 (COVID-19) affects multiple organ systems, particularly the lungs, where hypoxemia may occur. Musculoskeletal problems, fatigue, and exercise intolerance frequently occur. The effects of inspiratory muscle strength training (IMST) have not been adequately investigated in patients with post-COVID-19. This study aimed to investigate the effects of IMST on functional exercise capacity, muscle oxygenation and strength, fatigue, and dyspnea in patients with post-COVID-19 syndrome and…

Rank96.9
Randomized controlled trial

Recruitment of nursing homes and residents in a cluster-randomised controlled trial to improve oral health (MundZaRR): a structured analysis of trials and tribulations.

Trials · 2026 · PMID 41827070

BACKGROUND: The cluster-randomised controlled MundZaRR trial aimed to improve the oral health of nursing home (NH) residents through a complex intervention programme. Recruitment in NH settings is notably challenging. Since there is only a limited number of reports from comparable studies on recruitment, we aimed to analyse the challenges and barriers related to the recruitment process of MundZaRR. METHODS: NHs in Southwestern Germany were recruited by the study team, and residents via NH contact persons, e.g. NH m…

Rank96.9
Randomized controlled trial

Evaluating a Tailored Web-Based eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic: Randomized Clinical Trial.

Journal of medical Internet research · 2026 · PMID 42430132

BACKGROUND: Prostate cancer (PCa) is the most common nonskin cancer among men. Although treatments achieve excellent survival for localized PCa, long-lasting complications significantly diminish patients' quality of life (QOL) across physical, sexual, psychosocial, and general symptom domains. Because these effects also profoundly impact intimate partners, often reducing partners' QOL as much as or more than patients' QOL, supportive care must address the needs of both members of the couple. OBJECTIVE: This study e…

Rank96.9
Randomized controlled trialResult signal: null

Dexmedetomidine for sedation during noninvasive ventilation in COVID-19 patients from the Helmet-COVID randomized clinical trial post-hoc analysis.

Scientific reports · 2026 · PMID 42103809

Dexmedetomidine may be used in patients managed by noninvasive ventilation (NIV), but its associations with intubation, mortality and health-related quality of life (HRQoL) are unclear. Thus, we aimed to assess the use of dexmedetomidine in patients with COVID-19-induced acute hypoxemic respiratory failure requiring NIV and its associations with the 28-day intubation rate, 28- and 180-day mortality rate, and HRQoL. This post-hoc study of the Helmet-COVID trial analyzed data from NIV-managed patients who did and did…

Rank96.9
Randomized controlled trial

Repeated-dose behavioral intervention to reduce opioid overdose among overdose survivors with opioid use disorder: A two-site phase III randomized controlled trial.

Addiction (Abingdon, England) · 2026 · PMID 41261059

BACKGROUND AND AIMS: The emergence of fentanyl in the street market for opioids has limited the benefits of some interventions to manage opioid overdose; thus, preventing the occurrence of opioid overdose is essential. We tested a behavioral intervention shown to prevent heroin overdose in a pilot study, in two United States cities with prevalent fentanyl. DESIGN: Phase III two-site single-blinded randomized controlled trial of a repeated dose motivational interviewing intervention to reduce overdose (REBOOT) versu…

Rank96.9
Randomized controlled trialResult signal: null

Transdermal testosterone gel vs placebo in women with diminished ovarian reserve prior to in vitro fertilization: a randomized, clinical trial.

Nature communications · 2026 · PMID 41680203

Diminished ovarian reserve (DOR) is common in women with infertility and is associated with poorer in vitro fertilization (IVF) outcomes. Testosterone is widely used off-label in this patient group, although evidence for its efficacy and safety is limited. To address this, we conducted a triple-blind, placebo-controlled, randomized clinical trial evaluating whether transdermal testosterone gel prior to IVF improves clinical pregnancy rates in women with DOR. Females aged 18-43 with infertility and DOR according to …

Rank96.8
Randomized controlled trial

Development and initial testing of an online security prime writing intervention during COVID-19.

Anxiety, stress, and coping · 2026 · PMID 41038614

BACKGROUND AND OBJECTIVES: During the COVID-19 pandemic, we tested the efficacy of a one-week online security prime (SP) writing intervention in reducing distress among 254 adults (60+ years and/or having an underlying health condition). The efficacy of writing interventions can depend on several factors. Attachment orientations, characterized by dimensions of anxiety and avoidance, reflect individuals' tendencies in how they seek proximity to and rely on others for support, and influence how people experience and …

Rank96.7
Randomized controlled trialResult signal: null

Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 · PMID 41429349

OBJECTIVES: To report long-term clinical efficacy, safety, pharmacokinetics, immunogenicity and seroneutralization results of AZD7442 (monoclonal antibodies tixagevimab-cilgavimab) in patients hospitalized with COVID-19. METHODS: In this phase 3, double-blind, randomized, multicentre trial, hospitalized adults with PCR-confirmed SARS-CoV-2 infection were randomly assigned 1:1 to receive AZD7442 or placebo, and followed-up until day 456, with repeated blood sample collections until day 365. Clinical endpoints includ…

Rank96.6
Randomized controlled trialResult signal: null

A randomized controlled trial of adjunctive speleotherapy in asthma, COPD and long COVID.

Scientific reports · 2026 · PMID 42173973

Speleotherapy (underground climate therapy) is a non-pharmacological intervention for chronic respiratory diseases. This randomized controlled trial investigated whether a 3-week speleotherapy course (6 sessions, 2 h/week) improves respiratory outcomes in patients on standard background therapy with asthma, COPD, or Long COVID, and whether it affects blood CO2 levels. The control group did not receive speleotherapy but continued their standard therapy. A total of 208 patients (asthma: n = 107; COPD: n = 59; Long CO…

Rank96.4
Randomized controlled trialResult signal: null

Can An Innovative Physical Therapy Program Enhance Mobility in Middle-Aged and Older Veterans With Slow Walking Speed? A Randomized Controlled Trial.

Archives of physical medicine and rehabilitation · 2026 · PMID 41397627

OBJECTIVE: To investigate the efficacy of an innovative physical therapy program targeting mobility. DESIGN: Single-blinded randomized controlled trial. SETTING: Outpatient care VA regional tertiary care center. PARTICIPANTS: Community-dwelling middle-aged and older Veterans (N=150) with slow walking speed. INTERVENTIONS: Live Long Walk Strong (LLWS) is an 8-week, 10 (1-h/session) session outpatient physical therapy program. It was designed to enhance mobility by targeting impairments linked to mobility decline. It…

Rank96.4
Randomized controlled trial

Health-related quality of life in immunocompromised adults with mild-moderate COVID-19 treated with nirmatrelvir-ritonavir: results from the randomized, double-blinded EPIC-IC trial.

Health and quality of life outcomes · 2026 · PMID 41857593

BACKGROUND: Little is known about health-related quality of life (HRQoL) in immunocompromised people during and after COVID-19 illness. We describe HRQoL outcomes from the EPIC-IC trial, which included participants with immunocompromise and mild–moderate COVID-19. METHODS: EPIC-IC was a randomized, double-blind trial. Participants were assigned 1:1:1 to 5-day, 10-day, or 15-day nirmatrelvir-ritonavir (NMV/r) and completed the SF-36 and EQ-5D-5L through Week (W)24. HRQoL was analyzed across and by treatment arms for…

Rank96.0
Randomized controlled trialResult signal: null

A Randomised Controlled Trial Testing a Behavioural Intervention Program for the Prevention of Type 2 Diabetes Among American Indian Youth: The Tribal Turning Point Study.

Pediatric obesity · 2025 · PMID 40884258

BACKGROUND: American Indian youth experience a high risk of overweight/obesity and type 2 diabetes. OBJECTIVES: To evaluate the effect of a behavioural intervention on diabetes risk factors among American Indian youth with overweight/obesity. METHODS: Between 2018 and 2023, youth (7-10 years) were randomised to the tribal turning point (TTP) intervention (n = 87) or control arm (n = 95). Community coaches delivered the core intervention in the first 6 months (10 group classes, 4 individual sessions with motivationa…

Rank95.7
Randomized controlled trial

Safety and efficacy of convalescent plasma for COVID-19 in the pre-vaccine era, and implementation in a large healthcare system: A phase I/II randomized, multicentre clinical trial (PC-COVID).

Enfermedades infecciosas y microbiologia clinica (English ed.) · 2026 · PMID 42264588

INTRODUCTION: A phase 2 trial was conducted to evaluate the safety and efficacy of convalescent plasma (CP) for patients admitted with COVID-19 in the pre-vaccine era. METHODS: CP was compared to standard of care (SoC) in a randomized clinical trial in patients admitted with COVID-19 pneumonia and with either hypoxia and/or some underlying condition from April to December 2020 in 15 hospitals in Andalusia, Spain. The primary endpoints were adverse events and failure (all-cause death and need for mechanical ventilat…

Rank95.6
Randomized controlled trialResult signal: null

Effectiveness and safety of cyclosporine A in moderate to severe COVID-19: a randomized, open-label trial.

Scientific reports · 2026 · PMID 41702946

COVID-19 severity is strongly associated with hyperinflammation. Cyclosporine A (CSA), an interleukin-2 inhibitor with immunomodulatory and antiviral activity, has been proposed as a potential adjunctive therapy. This study evaluated the safety and efficacy of CSA in patients with moderate to severe COVID-19. We conducted A randomized, open-label phase III trial was conducted involving 66 patients with COVID-19. Participants were assigned to one of two groups: the CSA group (n = 23), receiving 6 mg/kg/day for 7-14 …

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Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.