Viral infections evidence library

Hepatitis C

A living PubMed evidence library for hepatitis C treatment, direct-acting antivirals, cure outcomes, reinfection, complications, and emerging research.

PubMed only Research ranked Conflicts shown Data downloadable

Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 143 non-retracted PubMed-indexed records for Hepatitis C. The structured collection includes 0 guideline or consensus records, 11 evidence syntheses/systematic reviews/meta-analyses, and 1 randomized or phase III studies. 142 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 126 of 143 included records.

Engine 0.3.2 Snapshot v2 Updated 2026-09-27 Download source data · CSV

PubMed records143Non-retracted records included

Last 24 months142Records found by the recent-research search

High-priority evidence12Syntheses, reviews, randomized and phase III studies

Effect estimates18Machine-readable values extracted from abstracts

COI statements88.1%Coverage within PubMed records

Funding records45PMIDs with grant/funding metadata

Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years

2022

2025

2026

Evidence composition

Study designs

Other or unclassified110

Systematic reviews11

Cohort studies7

Case reports4

Preclinical/laboratory4

Prospective cohorts3

Observational studies2

Randomized trials1

Preprint1

Transparency

Conflict-of-interest reporting

Reported no conflicts88

COI statement present25

Not reported in PubMed record17

Declared financial/industry relationship13

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract130

Harm signal9

Neutral/null signal3

Supportive signal1

Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0

0.250.51.02.04.0

not_reported Odds Ratio · PMID 42089097 · 2026

3.40 95% CI 1.24–9.20

not_reported Odds Ratio · PMID 42387461 · 2026

31.00

mortality Hazard Ratio · PMID 42626007 · 2026

3.10 95% CI 1.70–5.50

mortality Hazard Ratio · PMID 42626007 · 2026

2.20

not_reported Risk Ratio · PMID 42788928 · 2026

0.75 95% CI 0.70–0.79

not_reported Risk Ratio · PMID 42788928 · 2026

0.69 95% CI 0.60–0.79

not_reported Risk Ratio · PMID 42788928 · 2026

1.00 95% CI 0.97–1.04

not_reported Risk Ratio · PMID 42788928 · 2026

0.82 95% CI 0.76–0.89

not_reported Hazard Ratio · PMID 40411291 · 2025

0.84 95% CI 0.74–0.94

not_reported Odds Ratio · PMID 40861921 · 2025

262.00

not_reported Odds Ratio · PMID 40861921 · 2025

214.00

mortality Hazard Ratio · PMID 40980951 · 2025

0.29

not_reported Hazard Ratio · PMID 41133105 · 2025

1.00 95% CI 1.00–1.01

not_reported Odds Ratio · PMID 41211523 · 2025

2.88

View extracted numerical results 18

Publication	Outcome	Measure	Reported value	Source
Association of IL28B Polymorphisms With Hepatitis C Susceptibility in Southern Iran's β-Thalassemia Population: A Cross-Sectional Study.Health science reports · 2026	not_reported	Percentage Comparison	72.0percent vs 12.5percent	PMID 41467239
Safety and Drug-Drug Interaction Burden of Direct-Acting Antiviral Therapy for Hepatitis C: A Single-Center Community Hospital Analysis.International journal of hepatology · 2026	not_reported	Odds Ratio	3.4 95% CI 1.24–9.2	PMID 42089097
Seroprevalence of hepatitis C virus infection among individuals attending a private clinic in Luanda, Angola.BMC infectious diseases · 2026	not_reported	Odds Ratio	31.0 p = 0.003	PMID 42387461
Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis.World journal of nephrology · 2026	mortality	Hazard Ratio	3.1 95% CI 1.7–5.5 P = 0.003	PMID 42626007
Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis.World journal of nephrology · 2026	mortality	Hazard Ratio	2.2 P = 0.003	PMID 42626007
Associations Between Patient Language Preference and Hepatitis C Screening: Results From the DETECT Hep C Emergency Department Screening Trial.Annals of emergency medicine · 2026	not_reported	Risk Ratio	0.75 95% CI 0.7–0.79	PMID 42788928
Associations Between Patient Language Preference and Hepatitis C Screening: Results From the DETECT Hep C Emergency Department Screening Trial.Annals of emergency medicine · 2026	not_reported	Risk Ratio	0.69 95% CI 0.6–0.79	PMID 42788928
Associations Between Patient Language Preference and Hepatitis C Screening: Results From the DETECT Hep C Emergency Department Screening Trial.Annals of emergency medicine · 2026	not_reported	Risk Ratio	1.0 95% CI 0.97–1.04	PMID 42788928
Associations Between Patient Language Preference and Hepatitis C Screening: Results From the DETECT Hep C Emergency Department Screening Trial.Annals of emergency medicine · 2026	not_reported	Risk Ratio	0.82 95% CI 0.76–0.89	PMID 42788928
Impact of Hepatitis C Virus Clearance on Cardiovascular Risk: A Real-World Experience From the Nationwide Taiwan Hepatitis C Virus Registry.The Kaohsiung journal of medical sciences · 2025	not_reported	Hazard Ratio	0.84 95% CI 0.74–0.94	PMID 40411291
Temporal Dynamics and Treatment Outcomes of Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: A Multicenter Retrospective Study from South Korea.Gut and liver · 2025	response rate	Percentage Comparison	89.0percent vs 58.1percent p<0.001	PMID 40675927
National hepatitis B and C estimates for 2021: Measuring Canada's progress towards eliminating viral hepatitis as a public health concern.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025	not_reported	Odds Ratio	262.0	PMID 40861921
National hepatitis B and C estimates for 2021: Measuring Canada's progress towards eliminating viral hepatitis as a public health concern.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025	not_reported	Odds Ratio	214.0	PMID 40861921
Hepatitis C Eradication Improves Oncologic and Clinical Outcomes in Patients Treated With Atezolizumab Plus Bevacizumab.Liver international : official journal of the International Association for the Study of the Liver · 2025	mortality	Hazard Ratio	0.29 p = 0.003	PMID 40980951
Prediction of Hepatocellular Carcinoma After Direct-Acting Antiviral Therapy Using Agile 3+ and End-of-Treatment Alpha-Fetoprotein Levels in Patients With Hepatitis C.JGH open : an open access journal of gastroenterology and hepatology · 2025	not_reported	Hazard Ratio	1.0 95% CI 1.0–1.01 p = 0.02	PMID 41133105
Helicobacter pylori Infection Increases Thrombocytopenia and Inflammation in Patients With Hepatitis B and/or C: An Analytical Study in Cameroon.Health science reports · 2025	not_reported	Odds Ratio	2.88 p = 0.01	PMID 41211523
Helicobacter pylori Infection Increases Thrombocytopenia and Inflammation in Patients With Hepatitis B and/or C: An Analytical Study in Cameroon.Health science reports · 2025	not_reported	Odds Ratio	2.34 p = 0.09	PMID 41211523
Scalp haircuts, keloids and blood-borne virus transmission risk in South Africa-The SHAKA study.PloS one · 2025	not_reported	Odds Ratio	2.51 p = 0.02	PMID 41259314

Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage88.1%17 records have no COI statement exposed in PubMed.

Funding metadata coverage31.5%Coverage indicates whether grant/funding metadata was present, not independence or study quality.

Most frequently reported funding agencies

NIAID NIH HHS40

NIDA NIH HHS19

NCI NIH HHS16

NHLBI NIH HHS15

NIH HHS10

NIDDK NIH HHS9

NIAAA NIH HHS8

NIGMS NIH HHS7

View records with declared financial or industry relationships 12

A precision randomized trial to evaluate the impact of tailored hepatitis C treatment adherence support on HCV treatment outcomes among people who inject drugs in India: design and baseline characteristics of the STOP-C trial.

S.H.M. received materials support from Abbott. D.L.T. reports medical editing for UpToDate and scientific consulting for Merck, Excision Bio, and Evrys; none are related to this study. S.S.S. reports grants and products from Gilead Sciences to institutions not related to this study and products from Abbott Laboratories to institutions related to this study, reports honoraria from Gilead Sciences and Abbott Laboratories, and serves as the Managing Trustee of the YR Gaitonde Medical Educational and Research Foundation and on the Board of Directors of the Serious Fun Children’s Network. Other authors: none declared.

PMID 39572371 · 2025

Beyond Risk Factors: Rethinking Hepatitis B and Hepatitis C Screening in Primary Care.

M.B. has served as a speaker and advisory board member for Gilead, Roche, and Arbutus. J.C.R.‐C. has served as a speaker for Gilead.

PMID 40970664 · 2025

Clinical and demographic characteristics of participants in a hepatitis C treatment trial in rural Kentucky: How policies around treatment access may impact elimination efforts in the United States.

Jennifer Havens has served as a scientific consultant for Gilead Sciences, Inc., and Cepheid.

PMID 41653055 · 2026

HCV Testing and Treatment of Adults in the United States: 2014 Through 2021-Data From Two National Commercial Testing Laboratories.

Marc G. Ghany: None. John W. Ward: The Task Force for Global Health receives funds for the general support of the Coalition for Global Hepatitis Elimination from Abbott, Gilead, AbbVie, Dynavax, Merck, GSK, Siemens, Cepheid, Roche, Pharco, Zydus Life Sciences, governmental agencies and philanthropic organizations. Dr. Ward received no compensation for authorship of this manuscript. Nidhi Shukla: employed by AbbVie. Arina Kuznetsova, Zachary Baldwin, Shiyin Jiao, Jatinder Kaur and Katherine Kosch: employees of AbbVie and may own stock. Timothy R. Morgan: none.

PMID 41017733 · 2025

Hepatitis C Eradication Improves Oncologic and Clinical Outcomes in Patients Treated With Atezolizumab Plus Bevacizumab.

Giuseppe Cabibbo received advisory board and speaker fees for Bayer, Eisai, Ipsen, AstraZeneca, MSD, Roche, Gilead; Fabio Piscaglia received consultation fees from Astrazeneca, Bayer, Bracco, ESAOTE, EISAI, Exact Sciences, GE, IPSEN, MSD, Nerviano, Roche, Samsung, Siemens Healthineers; Francesco Tovoli received consultation fees from Roche, Ipsen, Eisai; Fabio Marra received consultation fees from Roche, MSD/EISAI, AstraZeneca, Ipsen; Massimo Iavarone participated in the advisory board and received speaker fees for Gilead Sciences, Bayer, AstraZeneca, Roche, Roche Diagnostics, EISAI, IPSEN and MSD; Roberta D'Ambrosio received advisory board and consultation fees from Gilead Science and AbbVie; Lorenza Rimassa received consulting fees from AbbVie, AstraZeneca, Basilea, Bayer, BMS, Eisai, Elevar Therapeutics, Exelixis, Genenta, Hengrui, Incyte, Ipsen, Jazz Pharmaceuticals, MSD, Nerviano Medical Sciences, Roche, Servier, Taiho Oncology, Zymeworks; lecture fees from AstraZeneca, Bayer, BMS, Eisai, Guerbet, Incyte, Ipsen, Roche, Servier; travel expenses from AstraZeneca and Servier; research grants (to Institution) from AbbVie, AstraZeneca, BeiGene, Exelixis, Fibrogen, Incyte, Ipsen, Jazz Pharmaceuticals, MSD, Nerviano Medical Sciences, Roche, Servier, Taiho Oncology, TransThera Sciences, Zymeworks; Francesca Romana Ponziani received speaker fees, advisory board fees and travel grants from Bayer, MSD, Roche, Eisai, Ipsen, Astra‐Zeneca, Gilead, Abbvie.

PMID 40980951 · 2025

Exploring the impact of graded alcohol use on atherogenic lipid profiles among Latinos with underlying chronic liver disease.

CONFLICT OF INTEREST STATEMENT. Mandana Khalili has received research grants (to her institution) from Gilead Sciences Inc. and Intercept Pharmaceutical Inc. Mandana Khalili has also served as a scientific consultant to Gilead Sciences Inc. and GlaxoSmithKline Pharmaceuticals. Shyam Patel, Laura Bull, Kian Salimi, Bokun Yang, Jacquelyn J. Maher, Kevin Siao, and Amy M. Shui do not have any disclosures relevant to this manuscript.

PMID 40022301 · 2025

Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design.

S.A.M. is named as an inventor on a U.S. provisional patent application (No. 63/945,526), filed December 19, 2025, entitled Methods and Systems for Identifying Disease-Relevant T-Cell Epitopes and Modified Self or Viral Mimics Using Tissue-Derived T-Cell Receptors, which is assigned to Vanderbilt University. Dr. Neil Greenspan is a Senior Editor for Pathogens and Immunity; he was not involved in the editorial assessment, peer review, or any editorial decisions related to this manuscript.

PMID 42598440 · 2026

National Prescribing Trends of Direct-Acting Antivirals for Hepatitis C.

Conflict of Interest Disclosures: Drs Kishore and Hayden reported consulting for the Equal Justice Initiative. Drs Kishore, Hayden, and Johnson reported being unpaid cofounders of EqualCure. Dr Kesselheim reported serving as an expert witness in cases against Gilead, Johnson & Johnson, generic manufacturers, and pharmacy benefits managers and serving as a consultant for Alosa Health. Dr Rome reported receiving grants from Humana, Elevance Health Public Policy Institute, and PCMA Foundation and personal fees from Alosa Health.

PMID 41879418 · 2026

Less Restrictive Medicaid Policies for Direct-Acting Antiviral Access Are Associated With Greater Declines in Hepatocellular Carcinoma Deaths.

Andrew M. Moon: Consulting TARGET RWE, Intercept Pharmaceuticals, IDEOlogy Health. Research funding (to institution) from DCN diagnostics. A. Sidney Barritt 4th: Consulting Madrigal, Mirium, Merck, BI, LifeEdit, Target RWE. Sasha Deutsch‐Link: Consulting Nanbar Health. Neil D. Shah: Consulting for GSK and Ipsen. For other authors, there are no additional disclosures or potential conflicts of interest.

PMID 41691615 · 2026

Pancreatic Ductal Adenocarcinoma After Hepatitis C Infection.

Conflict of Interest Disclosures: Dr Tate reported receiving grants from the National Institutes of Health during the conduct of the study. No other disclosures were reported.

PMID 41236736 · 2025

National hepatitis B and C estimates for 2021: Measuring Canada's progress towards eliminating viral hepatitis as a public health concern.

Competing interests The statements, findings, conclusions, views, and opinions expressed in this report are based in part on data obtained under licence from IQVIA Solutions Canada Inc. concerning the following information service(s): CompuScript and GPM Custom Solutions from January 2012 to December 2021. All Rights Reserved. The statements, findings, conclusions, views, and opinions expressed herein are not necessarily those of IQVIA Solutions Canada Inc. or any of its affiliated or subsidiary entities. MJB reports receiving presentation fees from AbbVie and Gilead, and grant funding from AbbVie, Gilead, and Cepheid. NK has received research funding from ViiV Healthcare, Abbvie, and Gilead, advisory fees from Gilead Sciences, ViiV Healthcare, Merck, and Abbvie, and speaker fees from Gilead Sciences, Abbvie, and Merck, all outside this work. MBK reports grants for investigator-initiated studies from ViiV Healthcare, AbbVie, and Gilead; and consulting fees from ViiV Healthcare, Merck, AbbVie, and Gilead.

PMID 40861921 · 2025

Estimated prevalence of hepatitis B and C among immigrants in Canada.

Competing interests JC has received research funds paid to his institution from Viiv Healthcare and Gilead. He has received honoraria as a speaker, paid by Viiv Healthcare and Gilead. He has also received the Canadian Association for HIV Research Health Care Professionals Travel Award to attend conferences.

PMID 40861919 · 2025

Current Standard-of-Care Sources

PMID 41312005

randomized controlled trial

A precision randomized trial to evaluate the impact of tailored hepatitis C treatment adherence support on HCV treatment outcomes among people who inject drugs in India: design and baseline characteristics of the STOP-C trial.

American journal of epidemiology · 2025

Efforts to eliminate the hepatitis C virus (HCV) as a public health problem must include people who inject drugs (PWID). We describe the design and baseline characteristics of the Supporting Treatment Outcomes among PWID trial, which evaluates whether HCV treatment outcomes in PWID can be optimized by tailoring treatment support in 7 PWID-focused integrated HIV/HCV prevention/treatment centers across India. The design is a 3-arm, individual-level precision-randomized trial. Leveraging empirical data, a prediction model assigned participants as minimal or elevated risk for failure. Minimal-risk participants were randomized 3:2:1 to low-intensity (basic services), medium-intensity (patient nav…

PMID 39572371

2 linked PMIDs1030 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, sustained virologic response, SVR12
Populations represented: HCV RNA; ALT; chronic hepatitis C; compensated cirrhosis
Mechanism: Not explicitly reported in the retrieved PubMed metadata or abstracts.

PMID 40970664 PMID 42798105

Conflicting Research

moderate-confidence evidence

Antiviral Agents · multiple reported outcomes

15 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

harm: 1unknown: 13null: 1

PMID 39572371 PMID 41305413 PMID 42608263 PMID 41593527 PMID 41653055 PMID 42101220 PMID 42787256 PMID 40257357 PMID 40600572 PMID 40650350

Failed or Negative Trials

No trial with a directly extractable failed/null primary finding has been processed yet.

Emerging and Experimental Research

Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.

unclassified · 2026 · PMID 41921952

Distribution and structural diversity of type IV internal ribosome entry sites.

preclinical or laboratory · 2026 · PMID 41633772

Structural bioinformatics approaches for predicting novel drug targets in hepatitis C virus proteins: a comprehensive analysis.

unclassified · 2025 · PMID 40707671

Network pharmacology and molecular docking reveal antiviral mechanisms of silver nanoparticles synthesized by Oscillatoria sp. against HCV pathogenesis.

preclinical or laboratory · 2025 · PMID 41387476

Functional Antigen-Specific CD8 TSCM Responses Are Associated with Repeated Clearance of Hepatitis C Virus Infection.

preclinical or laboratory · 2025 · PMID 41410180

Polyphenols as Antiviral Agents: Their Potential Against a Range of Virus Types.

preclinical or laboratory · 2025 · PMID 40732950

Evidence Gaps

No PubMed-indexed guideline identified

BACKGROUND: People with diabetes (PWD) exhibit a higher prevalence of Hepatitis C virus (HCV) infection, making them a crucial population for HCV screening and micro-elimination efforts. In light of the first published interdisciplinary consensus on managing/screening HCV in PWD, this study aims to evaluate the results and identify effective strategies for incorporating HCV screening and treatment into an existing diabetes care model managed by case managers. METHODS: This multicenter prospective program, initiated…

Validation of Texas Hepatocellular Carcinoma Consortium Risk Index in the Hepatocellular Carcinoma Early Detection Strategy Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026 · PMID 41672261

BACKGROUND & AIMS: We previously developed a hepatocellular carcinoma (HCC) risk stratification model, the Texas HCC Consortium Risk Index (THCC-RI), for patients with cirrhosis. In this cohort study, we aimed to externally validate THCC-RI in a prospective cohort of patients with cirrhosis. METHODS: We used data from the Hepatocellular Carcinoma Early Detection Strategy (HEDS) Study, a prospective cohort of patients with cirrhosis enrolled in regular HCC surveillance at 7 centers in the United States. Patients wer…

Rank74.6

Multicenter clinical study

The evolving HIV epidemic in Ontario, Canada: A retrospective analysis of new HIV diagnoses to identify subpopulations with persistent risk of HIV transmission.

Canadian journal of public health = Revue canadienne de sante publique · 2025 · PMID 40100336

OBJECTIVE: The objective of this study was to characterize new HIV diagnoses in key Ontario cities, in order to understand current drivers of continued HIV transmission to inform HIV testing and prevention efforts. METHODS: Chart reviews were carried out at four clinical sites in Ontario, Canada. The study population included individuals who were diagnosed with HIV in Ottawa, Hamilton, and Toronto between January 1, 2018, and December 31, 2020, and had no previous evidence of HIV documented. RESULTS: The total numb…

Rank72.8

Multicenter clinical study

Prevalence and Factors Associated With Hepatitis C in Danish Prisons, 2022-2024: A Multicentre Cross-Sectional Study.

Journal of viral hepatitis · 2026 · PMID 41772784

Prisons offer a critical opportunity for hepatitis C virus (HCV) elimination, yet current data from Danish correctional facilities are sparse. We conducted a cross-sectional study in 16 prisons across Eastern Denmark between October 2022 and August 2024, enrolling 651 incarcerated individuals. All participants underwent HCV antibody and RNA testing using dried blood spots and completed a bio-behavioural risk survey. The prevalence of HCV antibody and HCV RNA was 4.2% (n = 26) and 2.0% (n = 13) respectively. HCV exp…

Rank70.3

Prospective cohort study

Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis.

World journal of nephrology · 2026 · PMID 42626007

BACKGROUND: Acute kidney injury (AKI) complicates up to 65% of hospitalizations for decompensated cirrhosis and is associated with high short-term mortality. Traditional markers such as serum creatinine are unreliable in cirrhosis, while novel biomarkers like neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, and Doppler renal resistive index (RRI) show promise but have not been systematically validated in hepatitis C virus-endemic, resource-limited settings such as Egypt. AIM: To evaluate the diagnosti…

Rank60.0

Observational or cohort study

Seroprevalence and Risk Factors for Transfusion-transmitted Infections among Blood Donors in Dera Ismail Khan, Pakistan: A Single-Center Cross-sectional Study.

Journal of epidemiology and global health · 2026 · PMID 42414835

BACKGROUND: Although the highly prophylactic precautions and measures for keeping safe blood transfusions, transfusion-transmitted infections (TTIs) still constitute a remarkably significant risk in medicine. Few documents recorded the situation of TTIs in Dera Ismail khan (D.I. Khan) district, Pakistan so this study aimed to assess the prevalence of TTIs among blood donors in the district, to update and enhance the management of a secure blood supply. METHODS: A cross-sectional observational study was conducted at…

Rank53.6

Other PubMed-indexed publication

Incidence of antiretroviral therapy regimen modification and associated factors among People Living with HIV in Beijing, China.

PLOS global public health · 2025 · PMID 41183094

Durability of the initially prescribed antiretroviral therapy (ART) regimen is critical for long-term virologic suppression among people living with human immunodeficiency virus (HIV). However, data on the incidence of regimen modification and its associated factors remain limited in China. We aim to quantify the incidence of initially prescribed ART modification and identify associated baseline factors in China. Treatment-naïve adults (≥18 years) who initiated ART with complete regimen records and have documented …

Rank53.6

Other PubMed-indexed publicationResult signal: harm

Health Outcomes Associated with Asymptomatic Toxoplasma gondii Seropositivity in Young Adults: A Nationwide Matched Cohort Study.

Microorganisms · 2026 · PMID 42075177

Toxoplasma gondii establishes latent infection in a substantial proportion of the global population, yet the long-term health consequences of this infection remain incompletely characterized. We conducted a retrospective observational matched cohort study using longitudinal electronic health record data from a nationwide integrated healthcare provider, including members aged 18-45 years who underwent routine Toxoplasma serologic screening, typically performed in obstetric evaluation, excluding patients with clinica…

Rank53.0

Other PubMed-indexed publication

Beyond Risk Factors: Rethinking Hepatitis B and Hepatitis C Screening in Primary Care.

Liver international : official journal of the International Association for the Study of the Liver · 2025 · PMID 40970664

INTRODUCTION: Most international guidelines recommend screening for hepatitis B virus (HBV) and hepatitis C virus (HCV) only for individuals with risk factors or elevated ALT levels. However, this approach may not suffice to eradicate viral hepatitis. This study evaluates the application of EASL HBV and HCV screening guidelines in primary care centres (PCCs). METHODS: The study included two components: (1) A retrospective review (January 2021-March 2023) of microbiology data to determine testing rates, analyse clin…

Rank52.7

Other PubMed-indexed publication

Seroepidemiological Prevalence of Hepatitis B and C Virus Coinfection: A Large-Scale Retrospective Cohort Study in Istanbul.

Diagnostics (Basel, Switzerland) · 2026 · PMID 42793680

Background/Objectives: Hepatitis B (HBV) and hepatitis C (HCV) coinfection leads to the progression of liver disease and results in clinically serious outcomes. Continuous monitoring of epidemiological data is crucial for managing the regional disease burden. This study investigates the current seroprevalence of HBV and HCV, the prevalence of coinfection, and the rates of active replication in Istanbul. Methods: This retrospective analysis included 7131 patients evaluated at the Infectious Diseases and Gastroentero…

Rank51.7

Other PubMed-indexed publication

Diagnostic Accuracy of Serum-Based Fibrosis Scores for Clinically Significant Liver Fibrosis in an East Asian Cohort.

The Kaohsiung journal of medical sciences · 2026 · PMID 42781769

Serum-based fibrosis scores are widely used for noninvasive risk stratification in chronic liver disease; however, direct comparisons across liver disease etiologies remain limited, particularly in Asian populations with a high prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study retrospectively analyzed the data of adults who underwent transient elastography (FibroScan) at a university-affiliated hospital. Three fibrosis scores were evaluated: Fibrosis-4 index (FIB-4), aspartate …

Rank50.4

Other PubMed-indexed publication

Serological Screening for HIV, Hepatitis B, Hepatitis C, and Syphilis in Patients with Genital Molluscum Contagiosum: A Retrospective Cross-Sectional Study.

Viruses · 2026 · PMID 42797789

(1) Background: The available literature on sexually transmitted infections in patients with genital molluscum contagiosum is limited. In this study, we aimed to evaluate the serological test results and screening rate for sexually transmitted infections, including human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis, among patients with genital molluscum contagiosum. (2) Methods: In this retrospective cross-sectional study, we reviewed the medical records of patients aged ≥18 years diag…

Rank49.9

Other PubMed-indexed publicationResult signal: harm

Serological Profile of Hepatitis B, C, and D and Factors Associated With Hepatitis B Exposure and Vaccination Among Hemodialysis Patients in Northeastern Brazil.

International journal of nephrology · 2026 · PMID 42666474

INTRODUCTION: Hemodialysis patients are at increased risk for viral hepatitis due to treatment-related exposures and transmission routes, potentially worsening liver and kidney disease. However, updated regional data in Brazil are scarce. This study evaluated the seroprevalence of hepatitis B, C, and D viruses (HBV, HCV, and HDV) and analyzed risk factors associated with HBV infection among patients undergoing hemodialysis in Northeast Brazil. METHODS: This study corresponds to a cross-sectional evaluation of 293 p…

Rank49.1

Other PubMed-indexed publication

Emergency Department-Based Screening and Linkage-to-Care for Hepatitis B, C, and D in a Referral Hospital in Barcelona, Spain: Reduction in Hepatitis C Prevalence After Five Years.

Viruses · 2026 · PMID 42797761

BACKGROUND: Emergency Department (ED) viral hepatitis screening programs typically report short-term outcomes. We evaluated the medium-term impact of an ED-based screening for Hepatitis C (HCV), Hepatitis B (HBV), and Hepatitis D (HDV) viruses. METHODS: Prospective opportunistic screening conducted between January 2020 and December 2024 at a referral hospital in Barcelona. Adults attending the ED were screened for HBV, HCV, and HDV. Positive cases were evaluated and linked to care when appropriate. To assess screen…

Rank48.9

Other PubMed-indexed publication

Serum Granzyme B in Parkinson's Disease: A Case-Control Study of Diagnostic Association.

Journal of clinical medicine · 2026 · PMID 42795888

Background/Objectives: Parkinson's disease (PD) is a neurodegenerative disease with a heterogeneous nature. Many molecular pathways are engaged in PD pathogenesis. Granzyme B (GrB) is an enzyme released by CTLs and has roles in neuroinflammation, axonal degeneration, demyelination, and neuronal ischemic death. However, little is reported about its role in PD pathogenesis and deterioration. To evaluate the role of GrB in PD. Method: A total of 94 participants were recruited from outpatient neurology clinics (47 PD p…

Rank48.9

Other PubMed-indexed publication

Association between LDL-R (exon 8 C.1171 G > A) polymorphisms and response to antiviral therapy in hepatitis C virus infection.

Scientific reports · 2026 · PMID 41720870

The entry of the hepatitis C virus (HCV) into liver cells is closely associated with its interaction with the low-density lipoprotein receptor (LDL-R), which plays a crucial role in facilitating viral uptake. This study aimed to investigate the association between the LDL-R (exon 8 C.1171 G/A) gene polymorphism and response to antiviral therapy in patients infected with HCV. Participants were divided into three groups. Group I included 30 patients positive for both anti-HCV antibodies and HCV-RNA who did not respon…

Rank47.8

Other PubMed-indexed publication

Prevalence and Spectrum of Chronic Liver Disease Among Patients Seeking Health Care in Ghana.

Liver international : official journal of the International Association for the Study of the Liver · 2026 · PMID 41689365

BACKGROUND: Chronic liver diseases (CLD) leading to liver fibrosis and cirrhosis are a major cause of morbidity and mortality in sub-Saharan Africa and pose a significant burden on its health care systems. We aimed to elucidate the prevalence of fibrosis/cirrhosis in patients seeking health care in Kumasi, Ghana, and its underlying aetiologies. METHODS: In this cross-sectional study, we performed sonography, transient elastography as well as biochemical and virological analyses. RESULTS: Transient elastography indi…

Rank47.0

Other PubMed-indexed publication

[Effectiveness of donor selection in a blood bank].

Revista medica del Instituto Mexicano del Seguro Social · 2026 · PMID 42771817

Transfusion safety in Mexico depends on 2 essential pillars: The proper clinical selection of donors and the effective application of screening tests established in current regulations. Among these tests, it is included mandatory detection of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), as well as Trypanosoma cruzi and Treponema pallidum, all considered highly relevant pathogens due to their potential for bloodborne transmission and their clinical impact. Each year, thousand…

Rank45.0

Other PubMed-indexed publication

Opt-Out Screening for Blood-Borne Viruses in Trauma and Orthopaedic Admissions From the Emergency Department: Are We Meeting the Standards?

Cureus · 2025 · PMID 41341364

Background In the United Kingdom, blood-borne viruses (BBVs) such as Hepatitis B, Hepatitis C, and HIV continue to pose a significant health risk to the public. The national guidelines currently recommend that everyone attending the Emergency Department (ED) and having routine blood tests done is automatically offered testing for BBV, unless they choose to opt out. During their management, patients under the care of Trauma and Orthopaedics (T&O) are admitted from several different ED areas, which makes them a key g…

Infectious diseases (London, England) · 2026 · PMID 42036947

BACKGROUND: The association between ABO and Rhesus (Rh) blood groups and susceptibility to hepatitis C virus (HCV) infection remains uncertain. This systematic review and meta-analysis aimed to clarify these associations. METHODS: PubMed, Scopus, Embase, and MEDLINE were searched from inception to 23 January 2025. Studies reporting HCV infection by ABO and/or Rh blood group were eligible. Risk of bias was assessed using the NIH tools. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-…

Rank108.4

Systematic review or meta-analysis

The impact of HIV coinfection on mpox patients: a systematic review and meta-analysis.

Emerging microbes & infections · 2026 · PMID 42461714

A substantial proportion of mpox cases occur in people with HIV, but how HIV coinfection and immune status affect clinical outcomes remains unclear. We systematically searched major databases up to March 2025 for observational studies comparing mpox patients with and without HIV coinfection. Pooled effect sizes were calculated using random-effects models. Risk ratios (RRs) or standardized mean differences (SMDs) with 95% confidence intervals were used for dichotomous or continuous outcomes. Post hoc subgroup analys…

Rank107.9

Systematic review or meta-analysis

Efficacy and Long-Term Outcomes of Direct-Acting Antivirals in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

Gut and liver · 2026 · PMID 42379830

BACKGROUND/AIMS: The role of direct-acting antivirals (DAAs) in patients with hepatocellular carcinoma (HCC) remains uncertain due to conflicting data on virologic efficacy and long-term outcomes. METHODS: This meta-analysis investigated studies reporting the sustained virologic response (SVR), recurrence, and overall survival in patients with HCC treated with DAAs. RESULTS: Eighty-eight studies were included, comprising 8,839 patients with HCC who were treated with DAAs. The pooled SVR rate in patients with HCC wa…

Rank107.9

Systematic review or meta-analysis

Modeling Approaches to the Economic Evaluation of Microelimination Strategies for Hepatitis C Virus in High-Risk Populations.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026 · PMID 42061676

OBJECTIVES: Mathematical models inform hepatitis C virus (HCV) microelimination strategies in high-risk groups, but their reliability depends on underlying methodological choices. We systematically appraised the modeling methods used in economic evaluations of HCV microelimination published between 2015 and 2026. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (International Prospective Register of Systematic Reviews: CRD420251185978), we searched PubMed/MEDLINE, Emb…

Rank107.8

Systematic review or meta-analysisResult signal: benefit

Etiology-related differences in hepatic recompensation in decompensated cirrhosis under Baveno VII criteria: a systematic review and meta-analysis.

BMC gastroenterology · 2026 · PMID 42420862

Rank107.7

Systematic review or meta-analysisResult signal: benefit

First-line immunotherapy for advanced hepatocellular carcinoma: a network meta-analysis of randomized trials with overall and HBV/HCV-stratified efficacy and safety.

Frontiers in immunology · 2026 · PMID 42220514

BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized the front-line treatment of advanced hepatocellular carcinoma (HCC). However, the comparative efficacy and safety of different ICI-based regimens-and their consistency across etiologic subgroups [HBV, HCV, and non-HBV/non-HCV (NBNC)]-remain uncertain. This study conducted a Bayesian network meta-analysis (NMA) of recent randomized controlled trials (RCTs) to compare the first-line immunotherapy strategies both overall and by viral etiology. METHODS…

Rank107.3

Systematic review or meta-analysis

Viral hepatitis co-infections with tuberculosis in India: A systematic review and meta-analysis.

The Indian journal of medical research · 2026 · PMID 42295712

Background and objectives Tuberculosis (TB) and viral hepatitis (hepatitis B and C) co-infection is a significant threat in low-and middle-income countries like India. To optimise treatment protocols and prevent liver-related complications, it is essential to estimate the burden of these co-infections. This systematic review and meta-analysis were conducted to determine the prevalence of hepatitis B and C co-infection with tuberculosis in India. Methods In line with PRISMA guidelines, a systematic search of PubMed,…

Rank106.9

Systematic review or meta-analysisResult signal: harm

Effect of Direct-Acting Antiviral Therapy on Glycemic Control in Patients with Chronic Hepatitis C and Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Viruses · 2026 · PMID 41754582

The eradication of hepatitis C virus (HCV) with interferon-free direct-acting antivirals (DAAs) has transformed the management of chronic HCV infection. Chronic HCV infection is associated with an increased risk of type 2 diabetes mellitus (T2DM) and poor glycemic control. However, the magnitude and consistency of improvement in glycated hemoglobin (HbA1c) after DAA-induced sustained virologic response (SVR) in patients with established T2DM remain unclear. We conducted a systematic review and meta-analysis of six …

Rank106.4

Systematic review or meta-analysisResult signal: harm

Prevalence and risk factors for key infectious diseases amongst migrants to the UK: a systematic review.

BMC infectious diseases · 2026 · PMID 41776448

BACKGROUND: Migrants are at increased risk of infections including HIV, tuberculosis and viral hepatitis, with poorer outcomes. Early diagnosis and management can reduce morbidity, mortality and onward transmission. This systematic review summarises prevalence of HIV, latent and active tuberculosis and hepatitis B and C among UK migrants and evaluates associated risk factors. METHODS: PubMed/Medline, EMBASE, Web of Science and the Cochrane Library were systematically searched from 2004 to 11 June 2025. The review w…

Rank105.7

Systematic review or meta-analysis

Incidence and risk factors of post-transplant diabetes mellitus after kidney transplantation: a systematic review and meta-analysis.

Frontiers in endocrinology · 2026 · PMID 42267307

OBJECTIVE: In order to investigate the incidence rate of post-transplant diabetes mellitus (PTDM) patients and identify the risk factors, we conducted a systematic review of studies published after 2014. DATA SOURCES: PubMed, EMBASE, Cochrane Library, as well as Web of Science were comprehensively retrieved until June 24, 2024. SELECTION OF STUDIES: Extracted data via EndNote reference management software and evaluated the risk of bias through the Newcastle-Ottawa Scale (NOS). DATA EXTRACTION: Statistical analyses …

Rank105.3

Systematic review or meta-analysisResult signal: null

Synchronous Telemedicine Versus In-Person Care in Hepatitis C Treatment: A Systematic Review and Meta-Analysis.

Journal of viral hepatitis · 2026 · PMID 41603321

Inequitable access to HCV treatment persists, particularly for rural and marginalised populations. Synchronous telemedicine (TM) could mitigate access barriers, but its comparative effectiveness versus in-person care is uncertain. We performed a systematic review and meta-analysis comparing synchronous TM with in-person care for HCV. The primary outcome was sustained virologic response (SVR); secondary outcomes were treatment initiation and completion. Subgroup analyses examined study design, therapy era (interfero…

Rank105.0

Systematic review or meta-analysis

Prevalence of circulating hepatitis C virus genotypes and drug-resistant variants in former Soviet Union countries: A scoping review with genotype meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42269919

BACKGROUND: Despite high hepatitis C virus (HCV) prevalence in the Former Soviet Union (FSU), data on genotype distribution and resistance-associated substitutions (RAS) remain fragmented. This study aims to map the breadth of molecular epidemiological evidence on HCV genotypes and resistance in FSU. METHOD: We performed a scoping review with a genotype meta-analysis of 24 cross-sectional studies published in PubMed, Web of Science, and Google Scholar from 1990 to 2025. The systematic review was registered with PRO…

Rank103.0

Systematic review or meta-analysis

Recombinant multiepitope proteins for hepatitis C virus diagnosis: Systematic review.

International journal of biological macromolecules · 2026 · PMID 41980690

Hepatitis C virus (HCV) infection remains as major global health concern given the more than 50 million chronic cases recorded and the significant barriers to its early diagnosis, mainly in low-resource settings. Conventional serological assays rely on recombinant or synthetic antigens accounting for higher production costs and for limiting diagnostic accessibility. Recombinant multiepitope proteins have emerged as promising alternative for incorporating conserved antigenic regions from multiple HCV proteins, such …

Rank102.6

Systematic review or meta-analysis

Evaluating Infections in Solid Organ Donors Before Transplantation: A Systematic Review of Clinical Practice Guidelines.

Transplantation · 2026 · PMID 41805905

Rank102.2

Systematic review or meta-analysis

Comparative Impact of Active Versus Passive Surveillance on Hepatitis C Virus Testing Uptake, Diagnosis and Linkage to Care in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.

Tropical medicine & international health : TM & IH · 2026 · PMID 42153380

BACKGROUND: Hepatitis C virus (HCV) infection remains a major global health challenge, particularly in low- and middle-income countries (LMICs), where limited diagnostic access and weak surveillance hinder progress toward the World Health Organization's 2030 elimination targets. This review compared the effectiveness of active versus passive surveillance on HCV testing uptake, diagnosis, and linkage to care in LMICs. METHODS: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidel…

Rank102.0

Systematic review or meta-analysis

The global epidemiology of injecting drug use, HIV, viral hepatitis and tuberculosis among people who are incarcerated: a multistage systematic review.

The International journal on drug policy · 2026 · PMID 41651703

BACKGROUND: This global systematic review assesses the prevalence of injecting drug use (IDU) and key infectious diseases (HIV, hepatitis C virus [HCV], tuberculosis and hepatitis B virus [HBV]) among people who are incarcerated. METHODS: We conducted a systematic search of peer-reviewed (Medline, Embase, PsycINFO), internet, and grey literature databases, from January 2000 through 2nd June 2025 and engaged international experts and relevant agencies liaising with key agencies focused on incarcerated populations (W…

Rank102.0

Systematic review or meta-analysis

Global coverage of interventions for reduction of injecting drug use-related harm, HIV, viral hepatitis and tuberculosis in prisons and other carceral settings: A systematic review.

The International journal on drug policy · 2026 · PMID 41651702

BACKGROUND: People who are incarcerated experience disproportionately high rates of injecting drug use and infectious disease, including HIV, viral hepatitis and tuberculosis. However, comprehensive global data regarding the availability of services that prevent and manage infectious disease, injecting drug use and related harms remain limited and outdated. We provide the first systematic review to comprehensively examine the availability and coverage of infectious disease prevention, treatment, and harm reduction …

Rank100.0

Systematic review or meta-analysis

Seroprevalence of hepatitis C virus among refugees, asylum seekers, and internally displaced populations within Africa: A systematic review and meta-analysis.

Global public health · 2026 · PMID 41964104

Hepatitis C virus (HCV), an often overlooked public health concern, is highly prevalent among marginalized groups. Refugees, asylum seekers, and internally displaced people (RASIDP) constitute an underserved population in healthcare. Given that displacement rates are increasing and that HCV is endemic to many African countries, we aimed to determine the prevalence of HCV among RASIDP communities in Africa. Studies investigating HCV prevalence within RASIDP communities across Africa were identified via the following…

BMC infectious diseases · 2026 · PMID 42288770

BACKGROUND: The COVID-19 pandemic was associated with widespread health services disruption, including challenges in the management of chronic infectious diseases. However, evidence regarding reported changes in hepatitis C virus (HCV) care during this period remains limited and fragmented. We aimed to map the available evidence on reported changes in HCV care during the COVID-19 pandemic across the HCV cascade of care. METHOD: We conducted a scoping review following the Arksey and O'Malley methodological framework…

Most Effective Evidence Supported Treatments11 records

Rank107.8

Systematic review or meta-analysisResult signal: benefit

Etiology-related differences in hepatic recompensation in decompensated cirrhosis under Baveno VII criteria: a systematic review and meta-analysis.

BMC gastroenterology · 2026 · PMID 42420862

Rank100.0

Systematic review or meta-analysis

Global Systematic Review of the Measurement of Stigma Associated With People Living With Hepatitis B or Hepatitis C Viruses.

Journal of viral hepatitis · 2025 · PMID 40856266

Rank100.0

Systematic review or meta-analysis

Cancer medicine · 2025 · PMID 41201177

Rank95.0

Systematic review or meta-analysisCorrection flagged

Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC).

Clinical rheumatology · 2023 · PMID 36169798

Cryoglobulinemic vasculitis (CV) or mixed cryoglobulinemic syndrome (MCS) is a systemic small-vessel vasculitis characterized by the proliferation of B-cell clones producing pathogenic immune complexes, called cryoglobulins. It is often secondary to hepatitis C virus (HCV), autoimmune diseases, and hematological malignancies. CV usually has a mild benign clinical course, but severe organ damage and life-threatening manifestations can occur. Recently, evidence in favor of rituximab (RTX), an anti-CD 20 monoclonal an…

Rank92.0

Randomized controlled trial

A precision randomized trial to evaluate the impact of tailored hepatitis C treatment adherence support on HCV treatment outcomes among people who inject drugs in India: design and baseline characteristics of the STOP-C trial.

American journal of epidemiology · 2025 · PMID 39572371

Rank65.0

Prospective cohort study

Responding to the increase in substance use, HIV, HCV, and overdose in New England (RISE-NE): Protocol for a prospective cohort study.

PloS one · 2026 · PMID 42789600

BACKGROUND: High levels of opioid use, early introduction of drug supply contaminants, and increasing polysubstance use have led to intersecting epidemics of HIV, HCV, and overdose among people who use drugs (PWUD) in New England. Prevention services (e.g., syringe service programs, HIV testing) have been available in parts of New England for decades, yet significant service delivery gaps exist outside of major metropolitan areas. Further, racially minoritized PWUD face heightened discrimination in service settings…

Rank45.0

Other PubMed-indexed publication

Impact of the COVID-19 pandemic on hepatitis C care across the cascade of care: a scoping review.

BMC infectious diseases · 2026 · PMID 42288770

Rank45.0

Other PubMed-indexed publication

Hepatitis B virus prevalence, susceptibility and care engagement among vulnerable migrant populations in Rome.

Rank76.4

Multicenter clinical study

Validation of Texas Hepatocellular Carcinoma Consortium Risk Index in the Hepatocellular Carcinoma Early Detection Strategy Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026 · PMID 41672261

Rank74.6

Multicenter clinical study

The evolving HIV epidemic in Ontario, Canada: A retrospective analysis of new HIV diagnoses to identify subpopulations with persistent risk of HIV transmission.

Canadian journal of public health = Revue canadienne de sante publique · 2025 · PMID 40100336

Rank74.0

Multicenter clinical studyResult signal: benefit

Hepatitis C Eradication Improves Oncologic and Clinical Outcomes in Patients Treated With Atezolizumab Plus Bevacizumab.

Liver international : official journal of the International Association for the Study of the Liver · 2025 · PMID 40980951

BACKGROUND AND AIMS: Hepatitis C virus (HCV) is a key driver of hepatocellular carcinoma (HCC). However, the impact of HCV eradication on systemic therapy remains unclear. We aimed to assess the safety and efficacy of direct-acting antivirals (DAA) in patients treated with Atezolizumab plus Bevacizumab (AtezoBev). METHODS: This retrospective multicentre study included patients with HCV-related unresectable/advanced HCC treated with AtezoBev between 2021 and 2024. Three groups of patients were compared: Group A (n =…

Rank72.8

Multicenter clinical study

Prevalence and Factors Associated With Hepatitis C in Danish Prisons, 2022-2024: A Multicentre Cross-Sectional Study.

Journal of viral hepatitis · 2026 · PMID 41772784

Rank70.3

Prospective cohort study

Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis.

World journal of nephrology · 2026 · PMID 42626007

Rank65.0

Prospective cohort study

Responding to the increase in substance use, HIV, HCV, and overdose in New England (RISE-NE): Protocol for a prospective cohort study.

PloS one · 2026 · PMID 42789600

Rank63.3

Observational or cohort study

The role of insulin resistance in the development of hepatocellular carcinoma with computational analysis of IRS-1 interaction with HCV genotype 3 core protein.

PloS one · 2026 · PMID 42789558

The link between insulin resistance (IR) and hepatocellular carcinoma (HCC), especially in relation to HCV genotype-3 infection, is still poorly understood. In South Asian countries and among the peoples of the United States, this problem remains a major public health concern. According to previous studies, metabolic and viral interactomes have not been analyzed together, and hence this is a limitation of the study. This cross-sectional observational study involved 110 people, categorized into control (n=20), chron…

Rank60.0

Observational or cohort study

Seroprevalence and Risk Factors for Transfusion-transmitted Infections among Blood Donors in Dera Ismail Khan, Pakistan: A Single-Center Cross-sectional Study.

Journal of epidemiology and global health · 2026 · PMID 42414835

Rank55.9

Other PubMed-indexed publication

Validation of Risk Models for Predicting Post-SVR HCC in Real-World Surveillance Across Global Geographic Regions.

Liver international : official journal of the International Association for the Study of the Liver · 2026 · PMID 42257496

BACKGROUND & AIMS: Several clinical risk models have been proposed to stratify hepatocellular carcinoma (HCC) risk in patients with chronic hepatitis C virus (HCV) after sustained virologic response (SVR). However, validation efforts have focused on monocentric or country-specific cohorts, and it is unclear if clinical risk models can be broadly applied to global populations. We characterised regional variation in model performance for HCC risk stratification in post-SVR patients. METHODS: Four HCC clinical risk mo…

Rank53.6

Other PubMed-indexed publication

Incidence of antiretroviral therapy regimen modification and associated factors among People Living with HIV in Beijing, China.

PLOS global public health · 2025 · PMID 41183094

Rank53.6

Other PubMed-indexed publicationResult signal: harm

Health Outcomes Associated with Asymptomatic Toxoplasma gondii Seropositivity in Young Adults: A Nationwide Matched Cohort Study.

Microorganisms · 2026 · PMID 42075177

Preclinical Research4 records

Rank45.0

Other PubMed-indexed publication

First Detection and Phylogenetic Analysis of Equine Hepacivirus (EqHV) in Iran.

Veterinary medicine and science · 2026 · PMID 41420497

BACKGROUND: The recent identification of novel viruses associated with hepatitis in horses has prompted equine veterinarians to investigate the viral factors contributing to equine hepatitis. Hepacivirus equi (EqHV), a member of the Flaviviridae family within the Hepacivirus genus, has been detected in horses affected by hepatitis. Globally, EqHV is highly conserved, existing as a single genotype with three distinct subtypes (Subtypes 1-3). Numerous studies have detected the virus by PCR and identified EqHV-specifi…

Rank30.0

Preclinical or laboratory study

Functional Antigen-Specific CD8 TSCM Responses Are Associated with Repeated Clearance of Hepatitis C Virus Infection.

European journal of immunology · 2025 · PMID 41410180

Natural clearance of hepatitis C virus (HCV) infection occurs in about 25% of primary infections, but offers only partial protective immunity against re-infections. This study hypothesised that long-lived polyfunctional HCV-specific CD8+ memory stem T cells (TSCM) contribute to protective immunity in rare super-clearer subjects who repeatedly clear viraemia. Six super-clearers and four clearer-chronic subjects who resolved a primary infection but subsequently developed chronic infection were studied at multiple tim…

Rank30.0

Preclinical or laboratory study

Polyphenols as Antiviral Agents: Their Potential Against a Range of Virus Types.

Nutrients · 2025 · PMID 40732950

Polyphenols are structurally diverse plant metabolites that have attracted significant interest. Their compositions are versatile, depending on their structures, including the number of rings in the polyphenol composition. Based on these attributes, polyphenols can be classified as flavanols, anthocyanins, flavones, phenolic acids, stilbenes, and lignans. Polyphenols mainly possess inhibition of viral replication, interference with viral protein synthesis, and modulation of immune responses, providing significant a…

Rank30.0

Preclinical or laboratory study

Distribution and structural diversity of type IV internal ribosome entry sites.

RNA (New York, N.Y.) · 2026 · PMID 41633772

Internal ribosome entry sites (IRESs) are RNA sequences that facilitate cap- and end-independent translation initiation in eukaryotes. Type IV IRESs, which include the hepatitis C virus IRES, directly bind the 40S ribosomal subunit and require only a subset of canonical initiation factors to function. As the full extent of diversity and species distribution of type IV IRESs was unknown, we sought to identify and classify the architectural variation of all members. Using a secondary structure homology-based search m…

Promising Experimental Therapies2 records

Rank45.0

Other PubMed-indexed publication

Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.

Genome biology and evolution · 2026 · PMID 41921952

The immune system mediates the complex interaction between pathogenic microorganisms and their hosts. Despite its significance, the evolutionary mechanisms underlying immune system complexity in primates remain largely elusive. In this study, we investigated the evolution of the primate immune system by generating the first comprehensive catalog of immune-related genes through extensive phylogenomic sampling. Our analyses uncovered substantial genetic diversity in the evolution of the primate immune system, in the …

Rank45.0

Other PubMed-indexed publication

Structural bioinformatics approaches for predicting novel drug targets in hepatitis C virus proteins: a comprehensive analysis.

Scientific reports · 2025 · PMID 40707671

This study employs structural bioinformatics approaches to identify and evaluate potential drug targets within the Hepatitis C virus (HCV) proteome. Through integration of homology modeling, molecular docking, and molecular dynamics simulations, we analyzed the structural features and druggability of key HCV proteins. The research focused on predicting binding sites, evaluating protein-ligand interactions, and assessing the therapeutic potential of identified targets. Our findings revealed promising drug targets in…

Prospective Cohort Studies6 records

Rank76.4

Multicenter clinical study

Validation of Texas Hepatocellular Carcinoma Consortium Risk Index in the Hepatocellular Carcinoma Early Detection Strategy Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026 · PMID 41672261

Rank65.0

Prospective cohort study

Responding to the increase in substance use, HIV, HCV, and overdose in New England (RISE-NE): Protocol for a prospective cohort study.

PloS one · 2026 · PMID 42789600

Rank53.0

Other PubMed-indexed publication

Beyond Risk Factors: Rethinking Hepatitis B and Hepatitis C Screening in Primary Care.

Liver international : official journal of the International Association for the Study of the Liver · 2025 · PMID 40970664

Rank51.1

Other PubMed-indexed publicationResult signal: null

Scalp haircuts, keloids and blood-borne virus transmission risk in South Africa-The SHAKA study.

PloS one · 2025 · PMID 41259314

BACKGROUND: The most frequent transmission modes of blood-borne infections (BBI), including HIV, hepatitis B virus (HBV) and C (HCV), are well documented. South Africa, an HIV epicentre, with HBV endemicity and an additional HCV burden, raises the possibility of novel transmission means. A unique style of close shave haircut that can elicit folliculitis keloidalis nuchea (FKN), may produce bleeding during haircuts and possible BBI transmission. We designed a prospective case control study to evaluate the potential …

Rank49.1

Other PubMed-indexed publication

Emergency Department-Based Screening and Linkage-to-Care for Hepatitis B, C, and D in a Referral Hospital in Barcelona, Spain: Reduction in Hepatitis C Prevalence After Five Years.

Viruses · 2026 · PMID 42797761

Rank45.0

Other PubMed-indexed publication

Hepatitis B virus prevalence, susceptibility and care engagement among vulnerable migrant populations in Rome.

BMC infectious diseases · 2026 · PMID 42414913

Quality Of Life3 records

Rank100.0

Systematic review or meta-analysis

Global Systematic Review of the Measurement of Stigma Associated With People Living With Hepatitis B or Hepatitis C Viruses.

Journal of viral hepatitis · 2025 · PMID 40856266

Rank45.0

Other PubMed-indexed publication

Assessment of Health-Related Quality of Life in Patients Suffering From Chronic Liver Disease in a Tertiary Care Hospital: A Cross-Sectional Study.

Health science reports · 2025 · PMID 40937011

BACKGROUND AND AIMS: Chronic liver disease (CLD) significantly impairs health-related quality of life (HRQoL) due to its multifaceted impact on physical, psychological, and social well-being. Despite its prevalence in Pakistan, there is limited data on the specific HRQoL challenges faced by patients with CLD. This study aims to assess HRQoL in CLD patients using the Chronic Liver Disease Questionnaire (CLDQ) and identify factors influencing their quality of life. METHODS: A cross-sectional study was conducted in a …

Rank45.0

Other PubMed-indexed publication

Post-treatment life-trajectories among people who inject drugs who completed hepatitis C treatment with direct acting antivirals: A thematic analysis.

British journal of health psychology · 2025 · PMID 40650350

BACKGROUND: Hepatitis C Virus is a global health burden, particularly affecting people who inject drugs. Direct-acting antiviral treatment can cure almost all people infected with hepatitis C. However, the longer-term impacts on within people's life trajectories are unknown, although some suggest it may lead to fundamental behavioural changes. DESIGN: A cross-sectional exploratory retrospective qualitative design. METHODS: We interviewed 30 people who inject(ed) drugs and who had previously been treated with direct…

Effect of donor exclusion criteria on blood safety and volume of donations: a systematic review of modelling studies.

Bulletin of the World Health Organization · 2026 · PMID 41924344

Rank96.0

Systematic review or meta-analysisResult signal: null

Targeting Helicobacter pylori in liver-impaired populations: a systematic review of efficacy and safety.

Journal of clinical biochemistry and nutrition · 2025 · PMID 41312005

Rank96.0

Systematic review or meta-analysis

Psoriasis and Chronic Viral Infections (HIV, HBV, and HCV): Therapeutic Approach and Safety.

Medicina (Kaunas, Lithuania) · 2026 · PMID 42796402

Rank74.0

Multicenter clinical studyResult signal: benefit

Hepatitis C Eradication Improves Oncologic and Clinical Outcomes in Patients Treated With Atezolizumab Plus Bevacizumab.

Liver international : official journal of the International Association for the Study of the Liver · 2025 · PMID 40980951

Rank51.0

Other PubMed-indexed publication

High Efficiency and Safety of Hepatitis C Treatment Among People Who Inject Drugs in Vietnam.

Journal of viral hepatitis · 2025 · PMID 41017776

People who inject drugs (PWID) are highly affected by hepatitis C (HCV) worldwide, particularly in low- and middle-income countries (LMICs), where access to addiction services is often limited. Reducing the burden of HCV, as promoted by WHO, requires effective interventions in this high-risk population. Here, we report the safety and efficacy of a pangenotypic generic HCV treatment among PWID in Vietnam, using a sofosbuvir/daclatasvir regimen. PWID were screened for HCV at two community-based organisations (CBO) pr…

Rank50.3

Other PubMed-indexed publicationResult signal: null

Long-Term Outcomes of Heart Transplantation Using Hepatitis C-Positive Donors.

Transplantation proceedings · 2026 · PMID 42608263

BACKGROUND: The global shortage of donor organs has prompted the utilization of extended criteria donors, including those infected with hepatitis C virus (HCV). While direct-acting antivirals (DAAs) have made this strategy feasible, data regarding long-term outcomes in the Asian population remain limited. We aimed to evaluate the long-term survival outcomes of heart transplantation (HT) using HCV-positive donors in a single-center Asian cohort. METHODS: This retrospective study analyzed 451 adult HT recipients at a…

Rank49.9

Other PubMed-indexed publicationResult signal: harm

Serological Profile of Hepatitis B, C, and D and Factors Associated With Hepatitis B Exposure and Vaccination Among Hemodialysis Patients in Northeastern Brazil.

International journal of nephrology · 2026 · PMID 42666474

Rank49.3

Other PubMed-indexed publication

Safety and Drug-Drug Interaction Burden of Direct-Acting Antiviral Therapy for Hepatitis C: A Single-Center Community Hospital Analysis.

International journal of hepatology · 2026 · PMID 42089097

BACKGROUND: Polypharmacy leads to drug-drug interactions (DDIs) with direct-acting antivirals (DAAs). We quantified the DDI burden (Liverpool categories) and evaluated its association with effectiveness and safety. We assessed renal function as a predictor of adverse events (AEs) and reported loss to follow-up (LTFU). METHODS: We retrospectively analyzed 145 adults with chronic hepatitis C treated with glecaprevir/pibrentasvir (GLE/PIB) or sofosbuvir/velpatasvir (SOF/VEL) between February 2018 and October 2024. The…

Rank47.0

Other PubMed-indexed publication

Alcohol, clinical & experimental research · 2025 · PMID 40022301

BACKGROUND: Alcohol use and hepatitis C virus (HCV) often coexist and are associated with cardiovascular disease. One of the underlying drivers is dyslipidemia. We assessed lipid and lipoprotein levels and the relationship between alcohol use and atherogenic lipid profiles, specifically small dense low-density lipoprotein cholesterol (sdLDL-C), in Latinos with and without HCV. METHODS: From June 1, 2002, to January 1, 2016, 150 Latino adults underwent demographic, clinical, metabolic, lipid/lipoprotein, and genetic…

Rank35.0

Case report

Atezolizumab-bevacizumab rechallenge after immune checkpoint inhibitor-associated myocarditis in advanced hepatocellular carcinoma: a case report.

Frontiers in oncology · 2026 · PMID 42787141

BACKGROUND: atezolizumab-bevacizumab is the standard first-line systemic treatment for unresectable hepatocellular carcinoma (HCC). Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare but potentially life-threatening immune-related adverse event. Evidence regarding ICI rechallenge after myocarditis remains limited, particularly in patients with HCC. CASE PRESENTATION: We report the case of a 59-year-old man with hepatitis C-related cirrhosis and advanced HCC with portal vein tumor thrombosis, treated…

Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.