Library/Viral infections/Hepatitis C
Viral infections evidence library
Hepatitis C
A living PubMed evidence library for hepatitis C treatment, direct-acting antivirals, cure outcomes, reinfection, complications, and emerging research.
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Hepatitis C
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Complete Ranked PubMed Index
The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.
Current Standard Of Care60 records
Rank112.0
Clinical guideline or consensus statement
British journal of haematology · 2026 · PMID 41431438
This is a new British Society of Haematology (BSH) guideline which focuses on the management of hepatitis B and C (HBV and HCV) infection affecting people with bleeding disorders (PwBD), including those who cleared the infection many years previously. It is based on the European Association for the Study of the Liver (EASL) guidance and is a succinct practical guide for haematologists to support joint care with hepatology. It is compatible with the joint international guidance from the European Association for Haem…
Rank112.0
Clinical guideline or consensus statement
The Lancet. Haematology · 2025 · PMID 40306834
Viral hepatitis remains a global health challenge and immune status affects outcomes. In patients with haematological malignancies, including haematopoietic stem-cell transplantation recipients, viral hepatitis can be life-threatening due to the direct effects of the virus or the need to modify or delay chemotherapy. Additionally, haematopoietic stem-cell donors with past or current viral hepatitis infections might transmit the virus to recipients. The growing recognition of hepatitis E virus (HEV), advances in hae…
Rank110.0
Clinical guideline or consensus statement
Hepatology (Baltimore, Md.) · 2026 · PMID 41186418
BACKGROUND AND AIMS: Accumulating data related to prevention, surveillance and treatment of chronic hepatitis B (CHB) provided the impetus for this updated guideline, using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach.
METHODS: The guideline was developed in compliance with the National Academy of Medicine standards. The guideline panel developed structured questions following the Population, Intervention Comparison, Outcomes (PICO) framework. The panel addressed 6 PICO ques…
Rank110.0
Clinical guideline or consensus statement
Journal of the American Academy of Dermatology · 2025 · PMID 39725212
BACKGROUND: Hidradenitis suppurativa (HS) affects different patient populations that require unique considerations in their management. However, no HS guidelines for these populations exist.
OBJECTIVE: To provide evidence-based consensus recommendations for patients with HS in 7 special patient populations: (i) pregnancy, (ii) breastfeeding, (iii) pediatrics, (iv) malignancy, (v) tuberculosis infection, (vi) hepatitis B or C infection, and (vii) HIV disease.
METHODS: Recommendations were developed using the Grading…
Rank110.0
Clinical guideline or consensus statement
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026 · PMID 40197438
The Association of Ringside Physicians (ARP) emphasizes the importance of screening combat sports athletes for blood-borne infections, including hepatitis B, HIV, and hepatitis C, to mitigate transmission risks and ensure participant safety. Although transmission of hepatitis B and C and HIV in combat sports is rare, protecting athletes is of utmost importance. It is the recommendation of the ARP that all fighters participating in combat sports, in which the presence of blood is a common occurrence and is allowed d…
Rank110.0
Clinical guideline or consensus statement
Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 · PMID 41469898
The current French guidelines for the treatment of psoriasis date from 2019 and do not include the most up-to-date interventions. The Psoriasis Research Group of the French Society of Dermatology has developed new guidelines to provide updated decision-making algorithms for the systemic treatment of adult patients with moderate-to-severe psoriasis. The algorithms were created following a thorough review of existing psoriasis treatment guidelines and recent publications on new systemic therapies not included in prev…
Rank110.0
Clinical guideline or consensus statement
The Medical journal of Australia · 2025 · PMID 40976940
INTRODUCTION: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, the sixth most common cause of cancer death in Australia. With shifting aetiologies and a growing at-risk population, consistent routine surveillance recommendations are key to early detection of HCC and improved survival. We developed new evidence-based HCC surveillance guidelines for people at high risk in Australia due to liver disease and/or other risk factors. These guidelines were developed by a working group of expe…
Rank110.0
Clinical guideline or consensus statement
Gastroenterology · 2026 · PMID 42017860
DESCRIPTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in patients with cirrhosis. Although advancements in surgical, locoregional, and systemic therapies have improved outcomes for patients with early-stage HCC, most cases are diagnosed at later stages due to both the limitations of currently recommended surveillance modalities and their underuse, with fewer than 1 in 4 patients with cirrhosis receiving surveillance for this tumor. Current guidelines recommend semiannual surveillanc…
Rank110.0
Clinical guideline or consensus statement
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases · 2026 · PMID 42236454
Multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant tuberculosis (RR-TB) pose significant challenges to global tuberculosis prevention and treatment efforts. At present, the chemotherapy of MDR/RR-TB is still hampered by prolonged treatment duration and suboptimal success rates. In 2019, the Chinese Medical Association Tuberculosis Branch issued the Chinese Expert Consensus on the Treatment of MDR-TB and RR-TB, which has provided essential guidance for standardizing the diagnosis, treatment, and clin…
Rank110.0
Clinical guideline or consensus statement
Dermatology (Basel, Switzerland) · 2024 · PMID 37963431
BACKGROUND: Current infectious disease screening recommendations for hidradenitis suppurativa (HS) are adopted from recommendations in chronic plaque psoriasis. No HS-specific guidelines for infectious disease screening prior to immunomodulatory therapy have been developed.
OBJECTIVES: The aim of the study was to establish an expert Delphi consensus of recommendations regarding infectious disease screening prior to systemic immunomodulatory therapy in HS.
METHODS: Participants were identified via recent publication…
Rank110.0
Clinical guideline or consensus statement
Journal of hepatology · 2024 · PMID 38845253
Following the advent of direct-acting antivirals (DAAs), hepatitis C virus (HCV) infection can be cured in almost all infected patients. This has led to a number of clinical questions regarding the optimal management of the millions of patients cured of HCV. This position statement provides specific guidance on the appropriate follow-up after a sustained virological response in patients without advanced fibrosis, those with compensated advanced chronic liver disease, and those with decompensated cirrhosis. Guidance…
Rank110.0
Clinical guideline or consensus statement
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias · 2024 · PMID 39364991
The prevalence of active hepatitis C virus (HCV) infection is higher in hospital emergency departments (EDs) than in the general population. Numerous patients who seek emergency care are unaware that they have detectable viremia, yet they fall outside established ED protocols for HCV screening. Often they belong to groups with difficult access to health care who use the ED as their point of entry to the system. The aim of this consensus paper was to develop an approach to guide ED detection of HCV infection in all …
Rank110.0
Clinical guideline or consensus statement
Medycyna pracy · 2024 · PMID 39323355
The set up of new healthcare models by taking into account diagnosis and health education of the viral infection, aims to achieve the goals of the World Health Organization Global Health Sector Strategy on viral diseases for 2022-2030. In comparison to Europe, Poland is ranked among countries with an moderate prevalence of hepatitis B and C virus (HBV and HCV), also human immunodeficiency virus (HIV). An additional challenge is the changing epidemiological situation due to the impact of immigrants, resulting mainly…
Rank110.0
Clinical guideline or consensus statement
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias · 2024 · PMID 39807550
Hidden infections and late diagnoses are currently the main challenges of the HIV pandemic. Emergency departments (EDs) are one of the health care system's key resources addressing these challenges. In 2020, the Spanish Society of Emergency Medicine (SEMES) published recommendations for ordering HIV serology testing for patients with certain health conditions, and in 2021 SEMES launched the "Leave Your Mark" (Deja tu Huella - DTH) program to facilitate implementing the recommendations during emergency care. The pre…
Rank107.0
Clinical guideline or consensus statement
Annals of internal medicine · 2023 · PMID 38079642
DESCRIPTION: The Kidney Disease: Improving Global Outcomes (KDIGO) 2022 clinical practice guideline on prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease (CKD) is an update of the 2018 guideline from KDIGO.
METHODS: The KDIGO Work Group (WG) updated the guideline, which included reviewing and grading new evidence that was identified and summarized. As in the previous guideline, the WG used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach t…
Rank107.0
Systematic review or meta-analysis
BMC nephrology · 2025 · PMID 41013381
PURPOSE: Electrolyte disturbances, including hyponatremia, are common in cirrhosis, with hyponatremia already incorporated into the MELD-Na score as a prognostic marker. However, the prognostic role of serum chloride, the main extracellular anion, remains underexplored. Emerging evidence suggests hypochloremia is independently associated with increased mortality and acute kidney injury (AKI) in cirrhotic patients. Proposed mechanisms include dysregulated activation of the renin-angiotensin, vasopressin, and sympath…
Rank107.0
Clinical guideline or consensus statement
Obstetrics and gynecology · 2023 · PMID 37590986
PURPOSE: The purpose of this document is to describe the specific types of viral hepatitis, their implications during pregnancy, the risk of perinatal transmission, and issues related to both treatment and prevention of infection.
TARGET POPULATION: Pregnant or postpartum women and individuals who screen positive for viral hepatitis infection. The onset of these conditions may have predated the perinatal period or may have occurred for the first time in pregnancy or the first year postpartum.
METHODS: This guidelin…
Rank104.6
Systematic review or meta-analysis
Journal of gastrointestinal cancer · 2024 · PMID 37480425
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, including Australia. The absence of a consensus clinical practice guideline (CPG) specific to HCC management poses challenges in reducing morbidity, mortality, and improving patient recovery. This systematic review aims to evaluate the existing evidence and assess the potential of published guidelines, including those with an international scope, to provide guidance for healthcare professionals in Australia.
METHODS: El…
Rank103.5
Systematic review or meta-analysis
Aging · 2023 · PMID 37733676
BACKGROUNDS: Hepatocellular Carcinoma (HCC) is one of the most common malignant cancers in humans and has a high fatality rate. In recent years, researchers have verified that the Wnt/β-catenin signaling pathway affects the clinicopathological features and prognosis of patients with HCC. Although many studies have investigated the relationship between Wnt/β-catenin signaling pathway and HCC, the prognostic value of β-catenin in HCC remains inconclusive. CTNNB1 (Catenin Beta-1) is an important factor in the Wnt/β-ca…
Rank102.6
Systematic review or meta-analysis
Transplantation · 2026 · PMID 41805905
BACKGROUND: Donor-derived infection remains a risk in solid organ transplantation. Clinical practice guidelines inform best practices for donor evaluation and acceptance, although they vary across centers and regions. This study aimed to evaluate the quality and consistency of guidelines for the evaluation of infections in solid organ donors and to summarize their recommendations.
METHODS: We searched electronic databases and websites of professional organizations for clinical practice guidelines and consensus stat…
Rank90.0
Randomized controlled trialCorrection flagged
Ophthalmic epidemiology · 2025 · PMID 41025833
OBJECTIVE: To screen influencing factors of dry eye and evaluate a new diagnosis and treatment model combining tertiary hospitals with community health management.
METHODS: A total of 500 community residents from two Chinese hospitals between January - September, 2023 were included. Dry eye was diagnosed based on the presence of typical symptoms, an OSDI score > 13, a tear film break-up time (BUT) < 10 seconds, and/or a Schirmer I test (SIT) result < 10 mm/5 min, following the 2020 Chinese Dry Eye Expert Consensus.…
Rank85.0
Randomized clinical study
Journal of cardiac failure · 2025 · PMID 39900221
BACKGROUND: Heart transplantation from hepatitis C-positive donors is on the rise, yet there exists divergence in approaches to managing recipients of these organs. Practices range from prophylactic treatment of recipients prior to transplantation to delayed treatment following the detection of viremia, with no established consensus on the optimal approach.
METHODS: An online survey was conducted among the heart transplant centers in the United States and Canada from January 2023-February 2024. The survey gathered …
Rank81.9
Multicenter clinical study
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2026 · PMID 41253622
BACKGROUND: People with diabetes (PWD) exhibit a higher prevalence of Hepatitis C virus (HCV) infection, making them a crucial population for HCV screening and micro-elimination efforts. In light of the first published interdisciplinary consensus on managing/screening HCV in PWD, this study aims to evaluate the results and identify effective strategies for incorporating HCV screening and treatment into an existing diabetes care model managed by case managers.
METHODS: This multicenter prospective program, initiated…
Rank80.9
Multicenter clinical study
Journal of hepatology · 2025 · PMID 40056934
BACKGOUND & AIMS: The Baveno VII consensus introduced the term "recompensated cirrhosis," though few studies have examined its clinical relevance. We analyzed the rate and predictors of recompensation after sustained virological response (SVR) in patients with HCV and evaluated its impact on mortality and hepatocellular carcinoma (HCC) compared to compensated and decompensated cirrhosis.
METHODS: We performed a multicenter observational study enrolling 916 patients with HCV-related cirrhosis with a minimum follow-u…
Rank53.0
Other PubMed-indexed publication
Transfusion · 2024 · PMID 39434410
BACKGROUND: Transfusion-transmissible infection (TTI) prevalence among US blood donors has been widely documented. Here we estimate the prevalence of donors presenting with ≥2 TTIs (multiple infections past or present referred to as coinfections) and describe their demographics and associations.
METHODS: Data from the Transfusion-Transmissible Infections Monitoring System were compiled for October 2020-September 2023 (3 years). Prevalence per million donations (pmd) was calculated for each TTI coinfection combinati…
Evidence Syntheses60 records
Rank113.0
Systematic review or meta-analysis
Nefrologia · 2025 · PMID 41276383
Hepatitis C virus infection and chronic kidney disease are major public health issues globally and HCV plays activity in various organs and systems including kidneys. Recent large-scale epidemiological studies have highlighted the negative impact of HCV on the incidence and progression of chronic kidney disease in the adult general population of the western world. In addition, HCV-related glomerular disease is a well-known complication of chronic HCV and novel improvements concerning its management has been achieve…
Rank112.0
Clinical guideline or consensus statement
British journal of haematology · 2026 · PMID 41431438
This is a new British Society of Haematology (BSH) guideline which focuses on the management of hepatitis B and C (HBV and HCV) infection affecting people with bleeding disorders (PwBD), including those who cleared the infection many years previously. It is based on the European Association for the Study of the Liver (EASL) guidance and is a succinct practical guide for haematologists to support joint care with hepatology. It is compatible with the joint international guidance from the European Association for Haem…
Rank112.0
Systematic review or meta-analysis
Journal of epidemiology and global health · 2025 · PMID 41455870
Concurrent HBV, HCV, and HDV infections pose a global health challenge, worsening disease, treatment, and patient outcomes, and burdening healthcare. In Iran, no comprehensive review has assessed HBV/HCV and HBV/HDV coinfection rates. This study conducted a systematic review and meta-analysis per PRISMA 2020 guidelines. The study was prospectively registered in PROSPERO (CRD420251007210). A comprehensive search was conducted across international (PubMed, Scopus, Embase, Web of Science, Cochrane Library) and Iranian…
Rank110.0
Systematic review or meta-analysis
Neuroepidemiology · 2026 · PMID 40139168
INTRODUCTION: Gut dysbiosis is one of the environmental factors that might contribute to the development of Parkinson's disease (PD). The potential impact of antimicrobial agents on PD risk, particularly through dysbiosis and neuroinflammation, is an area of ongoing investigation, though findings remain inconsistent.
METHODS: This systematic review and meta-analysis aimed to assess the relationship between antimicrobial use and PD risk. After searching PubMed, Scopus, Web of Science, and Embase, ten studies involvi…
Rank110.0
Clinical guideline or consensus statement
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases · 2026 · PMID 42236454
Multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant tuberculosis (RR-TB) pose significant challenges to global tuberculosis prevention and treatment efforts. At present, the chemotherapy of MDR/RR-TB is still hampered by prolonged treatment duration and suboptimal success rates. In 2019, the Chinese Medical Association Tuberculosis Branch issued the Chinese Expert Consensus on the Treatment of MDR-TB and RR-TB, which has provided essential guidance for standardizing the diagnosis, treatment, and clin…
Rank110.0
Clinical guideline or consensus statement
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026 · PMID 40197438
The Association of Ringside Physicians (ARP) emphasizes the importance of screening combat sports athletes for blood-borne infections, including hepatitis B, HIV, and hepatitis C, to mitigate transmission risks and ensure participant safety. Although transmission of hepatitis B and C and HIV in combat sports is rare, protecting athletes is of utmost importance. It is the recommendation of the ARP that all fighters participating in combat sports, in which the presence of blood is a common occurrence and is allowed d…
Rank110.0
Clinical guideline or consensus statement
Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 · PMID 41469898
The current French guidelines for the treatment of psoriasis date from 2019 and do not include the most up-to-date interventions. The Psoriasis Research Group of the French Society of Dermatology has developed new guidelines to provide updated decision-making algorithms for the systemic treatment of adult patients with moderate-to-severe psoriasis. The algorithms were created following a thorough review of existing psoriasis treatment guidelines and recent publications on new systemic therapies not included in prev…
Rank110.0
Clinical guideline or consensus statement
Gastroenterology · 2026 · PMID 42017860
DESCRIPTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in patients with cirrhosis. Although advancements in surgical, locoregional, and systemic therapies have improved outcomes for patients with early-stage HCC, most cases are diagnosed at later stages due to both the limitations of currently recommended surveillance modalities and their underuse, with fewer than 1 in 4 patients with cirrhosis receiving surveillance for this tumor. Current guidelines recommend semiannual surveillanc…
Rank110.0
Clinical guideline or consensus statement
Hepatology (Baltimore, Md.) · 2026 · PMID 41186418
BACKGROUND AND AIMS: Accumulating data related to prevention, surveillance and treatment of chronic hepatitis B (CHB) provided the impetus for this updated guideline, using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach.
METHODS: The guideline was developed in compliance with the National Academy of Medicine standards. The guideline panel developed structured questions following the Population, Intervention Comparison, Outcomes (PICO) framework. The panel addressed 6 PICO ques…
Rank108.4
Systematic review or meta-analysis
Emerging microbes & infections · 2026 · PMID 42461714
A substantial proportion of mpox cases occur in people with HIV, but how HIV coinfection and immune status affect clinical outcomes remains unclear. We systematically searched major databases up to March 2025 for observational studies comparing mpox patients with and without HIV coinfection. Pooled effect sizes were calculated using random-effects models. Risk ratios (RRs) or standardized mean differences (SMDs) with 95% confidence intervals were used for dichotomous or continuous outcomes. Post hoc subgroup analys…
Rank108.3
Systematic review or meta-analysis
Frontiers in immunology · 2026 · PMID 41694404
INTRODUCTION: We conducted an etiology-stratified network meta-analysis of first-line systemic therapies for advanced HCC to compare newer regimens beyond sorafenib-based RCT evidence (HBV, HCV, or non-viral).
METHODS: Following PRISMA-NMA, we searched PubMed, Embase, Cochrane Library, and Web of Science to 01 June 2025 for first-line RCTs in advanced/unresectable HCC. Primary endpoints were overall survival (OS) and progression-free survival (PFS); secondary endpoints were objective response rate (ORR) and grade ≥…
Rank107.9
Systematic review or meta-analysis
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025 · PMID 41176147
OBJECTIVES: This study aimed to improve the understanding of the relative influence of schistosome and viral hepatitis coinfection on liver disease.
METHODS: We conducted a meta-analysis adhering to PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines to examine intestinal schistosome and hepatitis B or C coinfection in relation to liver fibrosis, cirrhosis, and hepatocellular carcinoma (PROSPERO CRD42023443435). Inverse-variance weighted random effects were used to calculate poole…
Rank107.9
Systematic review or meta-analysis
Gut and liver · 2026 · PMID 42379830
BACKGROUND/AIMS: The role of direct-acting antivirals (DAAs) in patients with hepatocellular carcinoma (HCC) remains uncertain due to conflicting data on virologic efficacy and long-term outcomes.
METHODS: This meta-analysis investigated studies reporting the sustained virologic response (SVR), recurrence, and overall survival in patients with HCC treated with DAAs.
RESULTS: Eighty-eight studies were included, comprising 8,839 patients with HCC who were treated with DAAs. The pooled SVR rate in patients with HCC wa…
Rank107.7
Systematic review or meta-analysisResult signal: benefit
Frontiers in immunology · 2026 · PMID 42220514
BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized the front-line treatment of advanced hepatocellular carcinoma (HCC). However, the comparative efficacy and safety of different ICI-based regimens-and their consistency across etiologic subgroups [HBV, HCV, and non-HBV/non-HCV (NBNC)]-remain uncertain. This study conducted a Bayesian network meta-analysis (NMA) of recent randomized controlled trials (RCTs) to compare the first-line immunotherapy strategies both overall and by viral etiology.
METHODS…
Rank107.3
Systematic review or meta-analysis
The Indian journal of medical research · 2026 · PMID 42295712
Background and objectives Tuberculosis (TB) and viral hepatitis (hepatitis B and C) co-infection is a significant threat in low-and middle-income countries like India. To optimise treatment protocols and prevent liver-related complications, it is essential to estimate the burden of these co-infections. This systematic review and meta-analysis were conducted to determine the prevalence of hepatitis B and C co-infection with tuberculosis in India. Methods In line with PRISMA guidelines, a systematic search of PubMed,…
Rank107.0
Systematic review or meta-analysis
BMC infectious diseases · 2025 · PMID 41233746
PURPOSE: Antituberculosis drug-induced liver injury (ATLI) is a common and serious adverse drug reaction of tuberculosis treatment. The impact of ATLI in patients with chronic hepatitis C is unclear. The aim of this study is to evaluate the prevalence of DILI in patients with and without HCV and assess its impact in the prevalence of ATLI.
METHODS: The preferred reporting items for systematic reviews and meta-analyses standards were followed, and the protocol was registered in PROSPERO. In this study, PubMed, Web o…
Rank106.9
Systematic review or meta-analysisResult signal: harm
Viruses · 2026 · PMID 41754582
The eradication of hepatitis C virus (HCV) with interferon-free direct-acting antivirals (DAAs) has transformed the management of chronic HCV infection. Chronic HCV infection is associated with an increased risk of type 2 diabetes mellitus (T2DM) and poor glycemic control. However, the magnitude and consistency of improvement in glycated hemoglobin (HbA1c) after DAA-induced sustained virologic response (SVR) in patients with established T2DM remain unclear. We conducted a systematic review and meta-analysis of six …
Rank106.9
Systematic review or meta-analysisResult signal: harm
Reproductive health · 2025 · PMID 41454412
INTRODUCTION: Several studies have identified an association between chronic hepatitis B (CHB), chronic hepatitis C (CHC), and an elevated risk of sexual dysfunction (SD). However, no systematic review or meta-analysis has been conducted to investigate this relationship. OBJECTIVE: This study aimed to provide an overview of the prevalence of SD and its associated risk factors in patients with CHB and/or CHC. METHODS: Databases including EMBASE, MEDLINE, and the Cochrane Library, were systematically searched from th…
Rank106.8
Systematic review or meta-analysis
BMC public health · 2025 · PMID 41286768
BACKGROUND: Hepatitis B (HBV) and hepatitis C (HCV) infections are significant global public health challenges. Correctional facilities face amplified and disproportionate risks due to overcrowding, limited healthcare access, and high-risk behaviours. There is a lack of consolidated prevalence and risk factor data on viral hepatitis in Nigerian correctional settings. This study synthesizes evidence on the prevalence of HBV and HCV, risk factors, and regional disparities within Nigerian correctional facilities. METH…
Rank106.4
Systematic review or meta-analysisResult signal: harm
BMC infectious diseases · 2026 · PMID 41776448
BACKGROUND: Migrants are at increased risk of infections including HIV, tuberculosis and viral hepatitis, with poorer outcomes. Early diagnosis and management can reduce morbidity, mortality and onward transmission. This systematic review summarises prevalence of HIV, latent and active tuberculosis and hepatitis B and C among UK migrants and evaluates associated risk factors.
METHODS: PubMed/Medline, EMBASE, Web of Science and the Cochrane Library were systematically searched from 2004 to 11 June 2025. The review w…
Rank105.7
Systematic review or meta-analysis
Frontiers in endocrinology · 2026 · PMID 42267307
OBJECTIVE: In order to investigate the incidence rate of post-transplant diabetes mellitus (PTDM) patients and identify the risk factors, we conducted a systematic review of studies published after 2014.
DATA SOURCES: PubMed, EMBASE, Cochrane Library, as well as Web of Science were comprehensively retrieved until June 24, 2024.
SELECTION OF STUDIES: Extracted data via EndNote reference management software and evaluated the risk of bias through the Newcastle-Ottawa Scale (NOS).
DATA EXTRACTION: Statistical analyses …
Rank105.3
Systematic review or meta-analysisResult signal: null
Journal of viral hepatitis · 2026 · PMID 41603321
Inequitable access to HCV treatment persists, particularly for rural and marginalised populations. Synchronous telemedicine (TM) could mitigate access barriers, but its comparative effectiveness versus in-person care is uncertain. We performed a systematic review and meta-analysis comparing synchronous TM with in-person care for HCV. The primary outcome was sustained virologic response (SVR); secondary outcomes were treatment initiation and completion. Subgroup analyses examined study design, therapy era (interfero…
Rank104.4
Systematic review or meta-analysisResult signal: harm
Journal of the American Heart Association · 2025 · PMID 41160032
BACKGROUND: We conducted a systematic review and meta-analysis of studies examining the association of viral infections with the risk of cardiovascular disease, including coronary heart disease (CHD) and stroke.
METHODS: MEDLINE, Embase, Web of Science, African-Wide Information, and the Cochrane Library database were searched from inception to July 2024.
RESULTS: We included 155 studies. HIV infection was consistently associated with an elevated risk of CHD (pooled adjusted risk ratio [RR], 1.60 [95% CI, 1.38-1.85]…
Rank103.4
Systematic review or meta-analysis
BMC infectious diseases · 2025 · PMID 41291465
BACKGROUND: Diagnosing human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in general population settings is challenging. We conducted a systematic review and meta-analysis of prediction tools designed to help identify individuals at risk of these blood-borne viruses. METHODS: We included studies on individuals of any age at risk of blood-borne viruses from healthcare, community settings, and national databases. We searched the Web of Science, MEDLINE, EMBASE, and CEN…
Rank103.0
Systematic review or meta-analysis
International journal of biological macromolecules · 2026 · PMID 41980690
Hepatitis C virus (HCV) infection remains as major global health concern given the more than 50 million chronic cases recorded and the significant barriers to its early diagnosis, mainly in low-resource settings. Conventional serological assays rely on recombinant or synthetic antigens accounting for higher production costs and for limiting diagnostic accessibility. Recombinant multiepitope proteins have emerged as promising alternative for incorporating conserved antigenic regions from multiple HCV proteins, such …
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