Viral infections evidence library

HIV Infection

A living PubMed evidence library for HIV prevention, antiretroviral therapy, long-acting treatment, resistance, comorbidities, and cure research.

PubMed only Research ranked Conflicts shown Data downloadable

Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 772 non-retracted PubMed-indexed records for HIV Infection. The structured collection includes 8 guideline or consensus records, 111 evidence syntheses/systematic reviews/meta-analyses, and 117 randomized or phase III studies. 264 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 560 of 772 included records.

Engine 0.3.2 Snapshot v2 Updated 2026-08-02 Download source data · CSV

PubMed records772Non-retracted records included

Last 24 months264Records found by the recent-research search

High-priority evidence228Syntheses, reviews, randomized and phase III studies

Effect estimates196Machine-readable values extracted from abstracts

COI statements72.5%Coverage within PubMed records

Funding records235PMIDs with grant/funding metadata

Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years

2002

2018

2020

2021

2022

2023

2024

2025

675

2026

Evidence composition

Study designs

Other or unclassified387

Randomized trials113

Preclinical/laboratory64

Meta-analyses57

Systematic reviews54

Prospective cohorts29

Cohort studies24

Observational studies13

Clinical guidelines8

Case reports8

Transparency

Conflict-of-interest reporting

Reported no conflicts277

COI statement present232

Not reported in PubMed record212

Declared financial/industry relationship51

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract695

Neutral/null signal33

Harm signal30

Supportive signal10

Mixed signal4

Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0

0.250.51.02.04.0

not_reported Risk Ratio · PMID 42263092 · 2026

1.52 95% CI 1.13–2.04

not_reported Risk Ratio · PMID 42263092 · 2026

1.49 95% CI 0.98–2.28

not_reported Odds Ratio · PMID 41493630 · 2026

12.00

not_reported Odds Ratio · PMID 42521123 · 2026

30.00

not_reported Odds Ratio · PMID 41501688 · 2026

1.68

not_reported Odds Ratio · PMID 42414619 · 2026

1.00

not_reported Odds Ratio · PMID 42414619 · 2026

30.00

not_reported Odds Ratio · PMID 42414619 · 2026

30.00

not_reported Odds Ratio · PMID 42414619 · 2026

10.00

not_reported Hazard Ratio · PMID 42454801 · 2026

0.51 95% CI 0.36–0.72

adverse events Risk Ratio · PMID 42486497 · 2026

8.00 95% CI 1.13–56.79

not_reported Risk Ratio · PMID 42486497 · 2026

1.57 95% CI 0.62–3.99

not_reported Risk Ratio · PMID 42486497 · 2026

1.51 95% CI 0.80–2.86

adverse events Risk Ratio · PMID 42486497 · 2026

2.95 95% CI 0.62–13.96

View extracted numerical results 60

Publication	Outcome	Measure	Reported value	Source
Promoting shared decision-making in colorectal cancer screening in primary care: A cluster randomized controlled trial.PloS one · 2026	not_reported	Risk Ratio	1.52 95% CI 1.13–2.04	PMID 42263092
Promoting shared decision-making in colorectal cancer screening in primary care: A cluster randomized controlled trial.PloS one · 2026	not_reported	Risk Ratio	1.49 95% CI 0.98–2.28	PMID 42263092
Individualized online exercise therapy aids recovery in pediatric long-COVID-findings from an exploratory randomized controlled trial.European journal of pediatrics · 2026	not_reported	Odds Ratio	12.0	PMID 41493630
Clinical course and virologic dynamics of Mpox during tecovirimat treatment: Prospective multicenter case series in Japan.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2026	not_reported	Odds Ratio	30.0	PMID 42521123
Baseline determinants of adherence for drug-sensitive TB treatment in a South African prospective cohort: a focus on HIV infection and anti-retroviral therapy, clinical care access, and TB stigma.BMC infectious diseases · 2026	not_reported	Odds Ratio	1.68	PMID 41501688
Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial.Nature medicine · 2026	not_reported	Odds Ratio	1.0	PMID 42414619
Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial.Nature medicine · 2026	not_reported	Odds Ratio	30.0	PMID 42414619
Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial.Nature medicine · 2026	not_reported	Odds Ratio	30.0	PMID 42414619
Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial.Nature medicine · 2026	not_reported	Odds Ratio	10.0	PMID 42414619
Determinants of HIV-1 virologic suppression in HIV-associated tuberculosis in Brazil.Memorias do Instituto Oswaldo Cruz · 2026	not_reported	Hazard Ratio	0.51 95% CI 0.36–0.72	PMID 42454801
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	adverse events	Risk Ratio	8.0 95% CI 1.13–56.79	PMID 42486497
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	not_reported	Risk Ratio	1.57 95% CI 0.62–3.99	PMID 42486497
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	not_reported	Risk Ratio	1.51 95% CI 0.8–2.86	PMID 42486497
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	adverse events	Risk Ratio	2.95 95% CI 0.62–13.96	PMID 42486497
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	not_reported	Risk Ratio	1.25 95% CI 0.62–2.54	PMID 42486497
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	not_reported	Risk Ratio	0.85 95% CI 0.55–1.32	PMID 42486497
Exercise for osteoarthritis of the hip.The Cochrane database of systematic reviews · 2026	adverse events	Risk Ratio	0.75 95% CI 0.58–0.97	PMID 42486497
Oral Lesions in People Living with HIV: The Lining HIV Study.Pathogens (Basel, Switzerland) · 2026	not_reported	Odds Ratio	0.377 p = 0.006	PMID 42515006
Effects of targeted interventions on HIV testing, knowledge and sexual risk behaviours among long-distance truck drivers: a systematic review and meta-analysis.BMJ open · 2026	not_reported	Risk Ratio	1.25 p=0.002	PMID 42457421
Effects of targeted interventions on HIV testing, knowledge and sexual risk behaviours among long-distance truck drivers: a systematic review and meta-analysis.BMJ open · 2026	not_reported	Risk Ratio	1.24 95% CI 1.13–1.36 p=0.002	PMID 42457421
Effects of targeted interventions on HIV testing, knowledge and sexual risk behaviours among long-distance truck drivers: a systematic review and meta-analysis.BMJ open · 2026	not_reported	Risk Ratio	0.86 p=0.002	PMID 42457421
Effects of targeted interventions on HIV testing, knowledge and sexual risk behaviours among long-distance truck drivers: a systematic review and meta-analysis.BMJ open · 2026	not_reported	Risk Ratio	1.14 p=0.248	PMID 42457421
Effectiveness of behavioural tobacco cessation interventions with and without pharmacotherapy among people living with HIV in Viet Nam: a three-arm pragmatic randomised controlled trial.The Lancet. Global health · 2026	not_reported	Odds Ratio	1.0	PMID 41713442
Assessing the impact of nicotinic partial agonists compared to NRT on opioid and cigarette use: A secondary analysis investigating treatment outcomes for co-occurring nicotine and opioid use.Journal of substance use and addiction treatment · 2026	not_reported	Odds Ratio	12.0	PMID 41558587
Factors associated with mortality and recurrence among patients with multidrug-resistant tuberculosis (MDR-TB): a systematic review, meta-analysis and meta-regression.Infectious diseases (London, England) · 2026	mortality	Odds Ratio	2.8 95% CI 1.92–4.09 p < .001	PMID 42017750
Factors associated with mortality and recurrence among patients with multidrug-resistant tuberculosis (MDR-TB): a systematic review, meta-analysis and meta-regression.Infectious diseases (London, England) · 2026	mortality	Odds Ratio	2.67 95% CI 1.64–4.38 p < .001	PMID 42017750
Factors associated with mortality and recurrence among patients with multidrug-resistant tuberculosis (MDR-TB): a systematic review, meta-analysis and meta-regression.Infectious diseases (London, England) · 2026	mortality	Odds Ratio	3.15 95% CI 2.28–4.36 p < .001	PMID 42017750
Factors associated with mortality and recurrence among patients with multidrug-resistant tuberculosis (MDR-TB): a systematic review, meta-analysis and meta-regression.Infectious diseases (London, England) · 2026	mortality	Odds Ratio	3.53 95% CI 1.03–12.09 p < .001	PMID 42017750
Factors associated with mortality and recurrence among patients with multidrug-resistant tuberculosis (MDR-TB): a systematic review, meta-analysis and meta-regression.Infectious diseases (London, England) · 2026	mortality	Odds Ratio	2.94 95% CI 1.08–8.0 p < .001	PMID 42017750
Renal outcomes with dolutegravir plus lamivudine versus bictegravir/emtricitabine/tenofovir alafenamide in ART-naive adults with HIV.AIDS (London, England) · 2026	not_reported	Percentage Comparison	29.9percent vs 16.8percent P > 0.05	PMID 42084114
Renal outcomes with dolutegravir plus lamivudine versus bictegravir/emtricitabine/tenofovir alafenamide in ART-naive adults with HIV.AIDS (London, England) · 2026	not_reported	Percentage Comparison	5.1percent vs 4.7percent P > 0.05	PMID 42084114
Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.International journal of antimicrobial agents · 2026	not_reported	Percentage Comparison	21.9percent vs 17.9percent P = 0.650	PMID 42055353
Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.International journal of antimicrobial agents · 2026	not_reported	Percentage Comparison	7.3percent vs 5.1percent	PMID 42055353
Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.International journal of antimicrobial agents · 2026	not_reported	Percentage Comparison	3.8percent vs 23.2percent P = 0.027	PMID 42055353
Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.International journal of antimicrobial agents · 2026	not_reported	Percentage Comparison	16.8percent vs 40.2percent P = 0.027	PMID 42055353
Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.International journal of antimicrobial agents · 2026	not_reported	Percentage Comparison	55.7percent vs 26.1percent P = 0.03	PMID 42055353
Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.International journal of antimicrobial agents · 2026	not_reported	Percentage Comparison	24.9percent vs 49.2percent P = 0.03	PMID 42055353
Syphilis infection and incident dementia in two real-world cohorts: A harmonized propensity-matched analysis in Taiwan NHIRD and TriNetX Asia-Pacific.Brain, behavior, and immunity · 2026	not_reported	Hazard Ratio	1.35 95% CI 1.23–1.48	PMID 42035811
Syphilis infection and incident dementia in two real-world cohorts: A harmonized propensity-matched analysis in Taiwan NHIRD and TriNetX Asia-Pacific.Brain, behavior, and immunity · 2026	not_reported	Hazard Ratio	1.64 95% CI 1.42–1.89	PMID 42035811
Syphilis infection and incident dementia in two real-world cohorts: A harmonized propensity-matched analysis in Taiwan NHIRD and TriNetX Asia-Pacific.Brain, behavior, and immunity · 2026	not_reported	Hazard Ratio	1.48 95% CI 1.22–1.79	PMID 42035811

Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage72.5%212 records have no COI statement exposed in PubMed.

Funding metadata coverage30.4%Coverage indicates whether grant/funding metadata was present, not independence or study quality.

Most frequently reported funding agencies

NIAID NIH HHS224

NHLBI NIH HHS85

NIH HHS70

NIMH NIH HHS34

FIC NIH HHS27

NIAAA NIH HHS24

NIDA NIH HHS21

NCATS NIH HHS21

View records with declared financial or industry relationships 12

Bodies, Boundaries, and Belonging: A Nurse's Guide to Providing Affirming Sexual Health Care for Transgender and Gender-Diverse Individuals.

Disclosures Dr A. Elliott is currently an employee of ViiV Healthcare. The statements and beliefs expressed in this article are solely those of the authors and does not reflect the position or beliefs of ViiV Healthcare. Drs C-H. Shrader and K. Duffy have no conflicts to disclose.

PMID 42527015 · 2026

In vitro and in vivo base editing of CCR5 in hematopoietic stem cells confers HIV-1 resistance.

Declaration of interests A.L. and H.-P.K. are academic co-founders of Ensoma Bio. H.-P.K. is a paid advisor for Ensoma Bio. S.R. is a consultant to Inograft Inc. and Ensoma Inc.

PMID 41832601 · 2026

Changes in weight and glycemia after initiation of integrase strand transfer inhibitors among people with HIV and diabetes.

Dr. Brown has served as a consultant to ViiV Healthcare, Gilead Sciences, Janssen, and EMD Serono. Dr. Alexander is past Chair of FDA’s Peripheral and Central Nervous System Advisory Committee and a co-founding Principal and equity holder in Stage Analytics. These arrangements have been reviewed and approved by Johns Hopkins University in accordance with its conflict-of-interest policies. Dr. Falade-Nwulia received grants from AbbVie to the institution and received advisory fees from Gilead Sciences. Dr. Marconi has received investigator-initiated research grants (to the institution) and research support from Eli Lilly, Bayer, Gilead Sciences, Merck, Pfizer, and ViiV Healthcare. Dr Kassaye contributed to the development of HIV educational materials for VINDICO CME. Other authors have no potential conflicts of interest to report.

PMID 41879108 · 2026

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV.

GT has received grants unrelated to this study and paid to her institution from Gilead Sciences Europe, UCL, ECDC, EU, and National funds. B.S. reports financial support for travel grants from Gilead Sciences and ViiV healthcare, and for advisory boards from Gilead Sciences and MSD, paid to his institution. MK reports grants for investigator-initiated studies from ViiV Healthcare, AbbVie, and Gilead; consulting fees from ViiV Healthcare, AbbVie, and Gilead, all outside the submitted work; and is supported by a Tier I Canada Research Chair. JMM has received consulting honoraria and/or research grants from Angelini, Gilead Sciences, Jansen, MSD, Novartis, Pfizer, and ViiV Healthcare. JMM received a personal 80:20 research grant from Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, during 2017–26.

PMID 41879095 · 2026

Utility of Artificial Intelligence-Driven Chatbots in Suggesting Solutions to Stapling Misadventures in Colorectal Surgery.

Declaration of Conflicting InterestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Steven Wexner is a consultant for Activ Surgical, Arthex, Baxter, Becton, Dickinson and Co., Intuitive Surgical, OstomyCure, Takeda, and Virtual Ports, has consulting agreements with stock options for consulting with GI View, OstomyCure, and Virtual Ports, is the Data Safety Monitoring Board chair of Polypid, and receives royalties from Intuitive Surgical, Karl Storz Endoscopy America Inc., and Unique Surgical Solutions, LLC. None of the remaining authors reports any conflicts of interest. Sameh Hany Emile, Preeti Singh, Nir Horesh, Lucia Oliveira, and Julio Mayol do not report any conflicts of interest.

PMID 41460110 · 2026

A 48-Week, Randomized Controlled Trial of Doravirine for Individuals With HIV and Obesity on Integrase Inhibitors and Tenofovir Alafenamide: The Do IT Study (ACTG A5391).

Potential conflicts of interest. J. R. K. has served as a consultant to Gilead, Merck, and Theratechnologies. He has received research support from Gilead and Merck, and provided expert testimony on behalf of Gilead. J. E. L. has served as a consultant to Gilead, ViiV, and Theratechnologies. K. E. has served as a consultant to Gilead, Merck, and ViiV and has received research support from Gilead and Theratechnologies. J. O’H. has received research support from Janssen. R. E. C. is a full-time employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, United States, and stockholder of Merck & Co., Inc., Rahway, NJ, United States. P. B.-Z is a contractor for the Division of AIDS at the National Institute of Allergy and Infectious Diseases. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.

PMID 41847923 · 2026

HIV tri-specific killer engagers directly enhance NK cell function and safely expand NK cells in vivo.

Declaration of interests M.F. and J.S.M. receive research support and, with the University of Minnesota, are shared owners of the TriKE technology licensed by the University to GT Biopharma, Inc. M.F. and J.S.M. also consult for GT Biopharma, Inc. M.F., Z.D., T.W.S., and J.S.M. are inventors on patents related to the TriKE platform and/or HIV-targeting TriKE molecules. M.F. and J.S.M. hold stock options in GT Biopharma, Inc., a company which may commercially benefit from the results of this research project. This relationship has been reviewed and managed by the University of Minnesota in accordance with its conflict-of-interest policy. R.T.C. holds stock in GT Biopharma, Inc. The content of this manuscript was not funded by GT Biopharma, Inc., and the data and design were under the control of the investigators.

PMID 42242227 · 2026

Burden of disease in US patients with skeletal versus muscular or pain manifestations of hypophosphatasia: An analysis from the Global HPP Registry.

Declaration of competing interest Priya Kishnani is a consultant for and has received research funding and honoraria from Alexion, AstraZeneca Rare Disease. Steven Ing has received research grants paid to his institution from Alexion, Amgen, Calcilytix, Radius, Takeda, and Ultragenyx and has served on an advisory board and/or as a consultant for Amgen, Bone Health & Osteoporosis Foundation, Extend Biosciences, and Radius. Julie Hoover-Fong has participated in advisory boards and served as a consultant for Ascendis, AstraZeneca, BioMarin, Children's Mercy Research Institute, Medscape, Pfizer, QED, and Therachon and has received research support from AstraZeneca, BioMarin, and QED. J. Carl Pallais has been a consultant for Alexion, AstraZeneca Rare Disease and Ensho Health and received research funding to his institution from Alexion, AstraZeneca Rare Disease. Angie Voskopoja, Shona Fang, and William R. Mowrey are employees of Alexion, AstraZeneca Rare Disease, and may hold stock or stock options in AstraZeneca. Eric Rush has received research funding to his institution from Alexion, AstraZeneca Rare Disease and Ultragenyx. He has received consulting fees and payment or honoraria from Alexion, AstraZeneca Rare Disease, Ultragenyx, Inozyme, Ipsen, and Kyowa Kirin. He has received support for meetings and/or travel from Alexion, AstraZeneca Rare Disease and Kyowa Kirin and participates on a data safety monitoring or advisory board for Inozyme. Kathryn Dahir is a clinical trial investigator and consultant for Alexion, AstraZeneca Rare Disease, Regeneron, Kyowa Kirin and Ultragenyx.

PMID 42365936 · 2026

Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester.

Potential conflicts of interest. A. G. reports Advisory Board roles from NIAID and Indo-US Science and Technology Forum (IUSSTF). M. H. reports institutional research and training grants related to infectious diseases from US NIH; board membership of Botswana-Harvard Partnership through employer; spouse's research grants from NIH related to infectious diseases research. C. A. B. reports institutional grant support for clinical trials from Gilead and DNAe; consulting fees (paid to author) from National Data and Analytics Platform (NDAP), Inc.; honoraria for medical education lectures and travel support (paid to author) from International Antiviral Society–United States (IAS-USA), a non-profit medical education entity; and unpaid positions as Present of the non-profit Conference on Retroviruses and Opportunistic Infections (CROI) Foundation Board, and Secretary/Treasurer of the IAS-USA Board of Directors. R. E. C. reports spouse's stock in Merck. S. S. reports institutional research support from ViiV Healthcare and participation on a Data Safety Monitoring or Advisory board for now completed NIH coronavirus disease (COVID)-related trials. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

PMID 37768207 · 2024

The emerging and evolving evidence supporting creatine as an ergogenic aid: history and applications.

CMK has received grants, honoraria, and consulting fees from companies who do business in areas related to exercise and nutrition. He currently serves as a scientific advisor to multiple companies who do business in exercise and nutrition, and he currently serves as a Scientific Affiliate for Alzchem and on a Scientific Advisory Board for NNB Nutrition, companies that manufacture creatine. DG conducted industry-sponsored research involving creatine supplementation and received creatine donations for scientific studies and travel support for presentations involving creatine supplementation at scientific conferences and serves on the Scientific Advisory Board for Alzchem, Create and Iovate (companies that manufacture creatine products). RBK has conducted industry-sponsored research on creatine through grants awarded to the universities he has been affiliated, received financial support for presenting invited lectures at conferences about sports nutrition and creatine. Additionally, he serves as Chair of the Scientific Advisory Board for AlzChem (a company that makes creatine monohydrate). He does not own any patents, receive royalties for the sale of creatine or any dietary supplement, or have any ownership in a company that sells creatine or any dietary supplements. TNZ has conducted industry sponsored research involving creatine supplementation and has received research funding from industry sponsors related to sports nutrition products and ingredients. JRS has received grants and contracts to research dietary supplements, has served as a paid consultant for industry, and received honoraria for speaking at conferences and writing lay articles about sports nutrition. He is a Chair of the Scientific Advisory Board for Alzchem. SF is a scientific advisor for Bear Balanced® and has received creatine donations from Creapure® for research purposes. PM and RS declare that no commercial or financial relationships exist that could be construed as a potential conflict of interest.

PMID 41870601 · 2026

Antiretroviral Activity, Pharmacokinetics, and Safety of MK-8527, an Oral Nucleoside Reverse Transcriptase Translocation Inhibitor, in Adults With HIV-1 Who Had Not Previously Taken Antiretroviral Agents: Results From 2 Open-Label, Phase 1 Studies.

Potential conflicts of interest. R. P. C., Y. K., R. C. V., A. B., G. G., C. C., A. A., X. Z., J.-F. D., C. L., T. R., R. P. M., S. A. S., M. I., and G. L. G. are current or former employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and may own stock and/or options in Merck & Co., Inc., Rahway, NJ, USA. All other authors report no potential conflicts. A. A., S. A. S., and M. I. are employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, at the time the study was conducted.

PMID 41830320 · 2026

Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

KME received grant funding from Gilead Sciences and has served as a consultant for ViiV, Merck, and Gilead (all of which were paid to the University of Colorado). SM serves as a consultant to ViiV.

PMID 42407092 · 2026

International journal of STD & AIDS · 2026

The 2026 British Association for Sexual Health and HIV (BASHH) guidelines for the management of viral hepatitis are in line with current evidence and practice within the United Kingdom. We provide evidence-based recommendations for the prevention, diagnosis and initial management of viral hepatitis A, B, C and D. Key updates are detailed at the start of the article.

PMID 42117446

EClinicalMedicine · PMID 42541296

Treatment Options Studied in the PubMed Collection

These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.

higher-confidence evidence

antiretroviral therapy

109 linked PMIDs63691 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, quality of life, mortality, viral suppression, HIV transmission, drug resistance, virologic failure, adverse events
Populations represented: general population; HIV-1; CD4 count; HIV-1; drug resistance; children; HIV-1; viral load
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 42103547 PMID 41656685 PMID 42538058 PMID 41860796 PMID 42541631 PMID 42070588 PMID 40983787 PMID 42517094

preliminary evidence

Anti-HIV Agents

80 linked PMIDs62931 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality, adverse events, viral suppression, drug resistance, quality of life, serious adverse events, virologic failure
Populations represented: general population; HIV-1; drug resistance; children; HIV-1; drug resistance; HIV-1; viral load
Mechanism: Ainuovirine (ANV), a novel non-nucleoside reverse transcriptase inhibitor, demonstrates a favorable preclinical safety profile Among the available antiretroviral therapies, non-nucleoside reverse transcriptase inhibitors (NNRTIs) play a crucial role by targeting viral reverse transcriptase (RT) through non-competitive inhibition

PMID 41656685 PMID 42155336 PMID 35077265 PMID 41632776 PMID 41832915 PMID 42163437 PMID 42189090 PMID 41498432

higher-confidence evidence

PrEP

30 linked PMIDs17288 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, HIV transmission, drug resistance, adverse events, quality of life
Populations represented: general population; HIV-1; second-line; drug resistance; locally advanced; advanced
Mechanism: Participants underwent individual randomization to 3 arms: (1) HAPA-based cognitive behavioral intervention featuring tailored WeChat messages and 2 structured motivational interviews targeting stage-specific barriers; (2) combined HAPA intervention with GCEI linked to peer group initiation rates, incorporating facilitated offline group activities; or (3) standard care control receiving nonpersonalized HIV prevention information Geographic targeting at ≥0.7% incidence was more cost-effective, averting approximately 8450 acquisitions at a net cost of US$8530 per acquisition averted

PMID 42184839 PMID 41983677 PMID 35077265 PMID 41632776 PMID 42008629 PMID 41832915 PMID 42536098 PMID 42360715

higher-confidence evidence

pre-exposure prophylaxis

26 linked PMIDs46823 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, HIV transmission
Populations represented: general population
Mechanism: Participants underwent individual randomization to 3 arms: (1) HAPA-based cognitive behavioral intervention featuring tailored WeChat messages and 2 structured motivational interviews targeting stage-specific barriers; (2) combined HAPA intervention with GCEI linked to peer group initiation rates, incorporating facilitated offline group activities; or (3) standard care control receiving nonpersonalized HIV prevention information

PMID 42184839 PMID 41181883 PMID 35077265 PMID 42475342 PMID 41632776 PMID 42008629 PMID 41832915 PMID 42536098

moderate-confidence evidence

Pyridones

19 linked PMIDs12147 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, viral suppression, serious adverse events, quality of life
Populations represented: general population; HIV-1; HIV-1; viral load; first-line; second-line; third-line
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 41348547 PMID 41539988 PMID 42097858 PMID 41891184 PMID 41665101 PMID 42170807 PMID 42125948 PMID 41805169

moderate-confidence evidence

Tenofovir

17 linked PMIDs14239 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, drug resistance, adverse events, viral suppression, quality of life
Populations represented: general population; drug resistance; HIV-1; first-line; HIV-1; viral load
Mechanism: BACKGROUND: Integrase inhibitors (INSTI) and tenofovir alafenamide (TAF) have been associated with greater weight gain compared to nonnucleoside reverse transcriptase inhibitors (NNRTIs) and tenofovir disoproxil fumarate (TDF), but the effects of an antiretroviral regimen switch on weight are unclear Ainuovirine (ANV), a novel non-nucleoside reverse transcriptase inhibitor, demonstrates a favorable preclinical safety profile

PMID 42541296 PMID 41832915 PMID 42264148 PMID 42502240 PMID 41539988 PMID 42391559 PMID 35545381 PMID 40755217

preliminary evidence

Anti-Retroviral Agents

13 linked PMIDs31596 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, viral suppression, adverse events, recurrence
Populations represented: general population; chronic HIV infection
Mechanism: Identifying factors contributing to poor adherence could refine targeting strategies and optimize resource distribution

PMID 41656685 PMID 42517094 PMID 41689280 PMID 42295005 PMID 41399124 PMID 35731794 PMID 42467806 PMID 42533069

preliminary evidence

Dolutegravir

12 linked PMIDs10703 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, quality of life, undetectable viral load, viral suppression
Populations represented: general population; children; first-line; HIV-1; first-line; viral load; second-line; third-line
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 41348547 PMID 42097858 PMID 41252594 PMID 41891184 PMID 42319215 PMID 42425238 PMID 42398161 PMID 42084114

preliminary evidence

HIV Antibodies

12 linked PMIDs138 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, virologic failure
Populations represented: HIV-1; general population; HIV-1; perinatal HIV; children; early-stage; HIV RNA; HIV-1; viral load
Mechanism: Notable progress includes promising results in germline-targeting and sequential immunization for the induction of broadly neutralizing antibody precursors, a better understanding of the mechanisms of reservoir persistence, and encouraging signals that immune-based strategies can lead to postintervention control This study (HVTN 140/HPTN 101) sought to evaluate PGDM1400LS (targeting V3-glycan) administered alone (part A, previously reported), and in combination (part B) with VRC07-523LS (targeting CD4 binding site) and PGT121.414.LS (targeting V2-apex) in healthy adults without HIV-1

PMID 34354709 PMID 41774769 PMID 42520014 PMID 39772772 PMID 42249623 PMID 42414619 PMID 42114530 PMID 42171686

moderate-confidence evidence

Antibodies, Neutralizing

10 linked PMIDs44317 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, virologic failure
Populations represented: general population; HIV-1; HIV-1; perinatal HIV; children; HIV-1; viral load
Mechanism: Neutralizing antibody (NAb) levels against 19 SARS-CoV-2 variants were measured using a multiplex bead-based flow cytometry assay This study (HVTN 140/HPTN 101) sought to evaluate PGDM1400LS (targeting V3-glycan) administered alone (part A, previously reported), and in combination (part B) with VRC07-523LS (targeting CD4 binding site) and PGT121.414.LS (targeting V2-apex) in healthy adults without HIV-1

PMID 41785679 PMID 41707950 PMID 39772772 PMID 42414619 PMID 42114530 PMID 42171686 PMID 42387620 PMID 42051541

preliminary evidence

Antitubercular Agents

10 linked PMIDs42074 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: mortality, reported clinical outcomes, recurrence
Populations represented: general population; children
Mechanism: INTERPRETATION: In this study, undernutrition, ever-smoking, and alcohol misuse accounted for more than one-third of all unfavorable treatment outcomes and may present high-yield intervention targets to improve TB treatment outcomes in India Identifying factors contributing to poor adherence could refine targeting strategies and optimize resource distribution

PMID 42017750 PMID 41921598 PMID 42244082 PMID 42538626 PMID 40147460 PMID 39733063 PMID 40939932 PMID 36650479

preliminary evidence

Piperazines

10 linked PMIDs10485 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, viral suppression, adverse events, quality of life
Populations represented: general population; HIV-1; viral load; HIV-1; first-line
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 41348547 PMID 42097858 PMID 41891184 PMID 41874003 PMID 41070447 PMID 42084114 PMID 42055353 PMID 41992416

preliminary evidence

Oxazines

9 linked PMIDs10485 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, viral suppression
Populations represented: general population; HIV-1; first-line; second-line; third-line
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 41348547 PMID 42097858 PMID 41891184 PMID 41070447 PMID 42084114 PMID 42055353 PMID 41992416 PMID 41665101

preliminary evidence

Heterocyclic Compounds, 3-Ring

9 linked PMIDs10485 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, viral suppression, quality of life
Populations represented: general population; HIV-1; first-line
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 41348547 PMID 42097858 PMID 41891184 PMID 41070447 PMID 42084114 PMID 42055353 PMID 41992416 PMID 41665101

limited evidence

Biomarkers

8 linked PMIDs5604 reported cumulative sample signal

Research status: harm signal
Outcomes represented: reported clinical outcomes, mortality
Populations represented: general population; CD4 count; HIV RNA; CD4 count
Mechanism: Bioinformatic network analysis was performed to identify potential molecular targets In silico network analysis suggested potential inflammatory and metabolic targets of miR-23a-3p; however, these findings require experimental validation

PMID 42041228 PMID 40530901 PMID 42449934 PMID 41734663 PMID 42019744 PMID 40576558 PMID 41639021 PMID 41991901

preliminary evidence

HIV Integrase Inhibitors

7 linked PMIDs5590 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, drug resistance, mortality, virologic failure
Populations represented: general population; HIV-1; drug resistance
Mechanism: OBJECTIVES: We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2

PMID 41921079 PMID 42097858 PMID 41891184 PMID 42320813 PMID 42198743 PMID 42398161 PMID 42485628

preliminary evidence

Lamivudine

7 linked PMIDs5254 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, viral suppression, virologic failure
Populations represented: HIV-1; first-line; general population; viral load
Mechanism: Ainuovirine (ANV), a novel non-nucleoside reverse transcriptase inhibitor, demonstrates a favorable preclinical safety profile Those with prior Non-Nucleoside Reverse Transcriptase Inhibitor failure or 3TC resistance were excluded

PMID 41665101 PMID 42086178 PMID 41070447 PMID 42084114 PMID 42055353 PMID 41992416 PMID 42418369

moderate-confidence evidence

Emtricitabine

7 linked PMIDs2434 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: adverse events, viral suppression, serious adverse events, reported clinical outcomes, quality of life
Populations represented: HIV-1; general population; HIV-1; viral load
Mechanism: Not explicitly reported in the retrieved PubMed metadata or abstracts.

PMID 41070447 PMID 42105781 PMID 42055353 PMID 42264148 PMID 42306935 PMID 42517223 PMID 41703498

Conflicting Research

higher-confidence evidence

antiretroviral therapy · multiple reported outcomes

89 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 82benefit: 1harm: 3null: 2mixed: 1

PMID 42103547 PMID 42490547 PMID 41656685 PMID 42044724 PMID 42538058 PMID 37548796 PMID 41860796 PMID 42047974 PMID 41806928 PMID 42541631

higher-confidence evidence

Anti-HIV Agents · multiple reported outcomes

60 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 53benefit: 1harm: 3null: 3

PMID 42490547 PMID 41656685 PMID 42044724 PMID 42171901 PMID 42155336 PMID 41847923 PMID 42339560 PMID 35077265 PMID 41632776 PMID 42055353

higher-confidence evidence

Antitubercular Agents · multiple reported outcomes

19 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 17null: 1benefit: 1

PMID 42017750 PMID 39012226 PMID 41501688 PMID 36041016 PMID 41666121 PMID 41408415 PMID 41619753 PMID 36650479 PMID 33430786 PMID 35943252

higher-confidence evidence

Tenofovir · multiple reported outcomes

17 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 14null: 2harm: 1

PMID 42171901 PMID 41847923 PMID 42541296 PMID 42055353 PMID 41251867 PMID 39882974 PMID 42479941 PMID 41832915 PMID 42264148 PMID 42502240

higher-confidence evidence

Isoniazid · multiple reported outcomes

9 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1benefit: 1unknown: 7

PMID 36041016 PMID 41666121 PMID 36476206 PMID 41619753 PMID 36650479 PMID 35943252 PMID 37634517 PMID 36622148 PMID 42244082

moderate-confidence evidence

antiretroviral therapy · multiple reported outcomes

7 studies

Status: apparently conflicting; different clinical questions. Population: CD4 count. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 5harm: 1mixed: 1

PMID 33387480 PMID 41098140 PMID 42190668 PMID 37768207 PMID 41639021 PMID 41747748 PMID 42075025

moderate-confidence evidence

Biomarkers · multiple reported outcomes

7 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1harm: 1unknown: 5

PMID 42041228 PMID 40576558 PMID 40530901 PMID 42449934 PMID 42084015 PMID 41734663 PMID 42019744

higher-confidence evidence

Caffeine · reported clinical outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1mixed: 1unknown: 2

PMID 42228847 PMID 41918248 PMID 41754174 PMID 42124064

moderate-confidence evidence

Papillomavirus Vaccines · reported clinical outcomes

4 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1unknown: 2benefit: 1

PMID 42459477 PMID 42499163 PMID 41586588 PMID 41649263

moderate-confidence evidence

antiretroviral therapy · multiple reported outcomes

3 studies

Status: apparently conflicting; different clinical questions. Population: HIV-1; CD4 count. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

harm: 1null: 1unknown: 1

PMID 35107660 PMID 41967778 PMID 42534220

moderate-confidence evidence

Chewing Gum · reported clinical outcomes

2 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1mixed: 1

PMID 42228847 PMID 41754174

preliminary evidence

Anti-Retroviral Agents · mortality

2 studies

Status: apparently conflicting; different clinical questions. Population: CD4 count. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 1mixed: 1

PMID 33387480 PMID 42288973

Failed or Negative Trials

Adenovirus type 5 vector-based COVID-19 vaccine does not increase the likelihood of HIV infection.

randomized controlled trial · 2026 · PMID 41785679

A Randomized Trial to Compare Dolutegravir Plus Boosted Darunavir Versus Recommended Standard of Care Antiretroviral Regimens in People With HIV-1, Whose First-line Non-nucleoside Reverse Transcriptase Inhibitor Therapy Has Failed: Final 96-week Results of the D2EFT Study.

randomized controlled trial · 2026 · PMID 40577173

Comparison of the Hearing Benefits and User Satisfaction With Hearing Aids and Personal Sound Amplification Products: A Multicenter Prospective Randomized Crossover Trial.

randomized controlled trial · 2026 · PMID 42011002

Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial.

randomized controlled trial · 2026 · PMID 41877274

LC16m8 for Pre-exposure Prophylaxis Against Mpox in a High-Risk Population: An Open-Label Randomized Trial.

randomized controlled trial · 2026 · PMID 39982831

Efficacy and safety of the Chinese herbal medicine Yiaikang capsule in treating AIDS: a randomized, double-blind, controlled trial.

randomized controlled trial · 2026 · PMID 41967778

Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults With HIV (INSTINCT/GESIDA10918 Study).

randomized controlled trial · 2026 · PMID 41070447

Promoting shared decision-making in colorectal cancer screening in primary care: A cluster randomized controlled trial.

randomized controlled trial · 2026 · PMID 42263092

HIV Care Retention and Cost Analysis in Multi-Month ART Dispensing: A Randomized Controlled Trial in China.

randomized controlled trial · 2026 · PMID 42339560

Baseline determinants of adherence for drug-sensitive TB treatment in a South African prospective cohort: a focus on HIV infection and anti-retroviral therapy, clinical care access, and TB stigma.

randomized controlled trial · 2026 · PMID 41501688

Emerging and Experimental Research

The Effectiveness of Artificial Intelligence in Undergraduate Health Professions Education: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

meta analysis · 2026 · PMID 42085678

A Systematic Review of Quantitative Health Preference Methods to Support Value Clarification and Shared Decision Making: A Report of an ISPOR Special Interest Group.

systematic review · 2026 · PMID 42000134

Implementation of therapeutic adherence in adult patients diagnosed with the Human Immunodeficiency Virus: A systematic review.

systematic review · 2026 · PMID 42155336

Integrating smoking cessation into HIV care settings: A systematic review and meta-analysis of effectiveness and the evidence gap in cost-effectiveness.

meta analysis · 2026 · PMID 42531253

Islatravir distribution in plasma, peripheral blood mononuclear cells, and mucosal tissues after monthly oral dosing.

randomized controlled trial · 2026 · PMID 41789892

[Cochlear implantation in Ménière's disease].

systematic review · 2026 · PMID 41644838

Effects of Semaglutide on Cognitive Function in People With HIV: A Randomized, Controlled Trial.

randomized controlled trial · 2026 · PMID 41098140

Interventions to improve access to sexual and reproductive health services for adolescents living with HIV in sub-Saharan Africa: a scoping review.

systematic review · 2026 · PMID 42331589

Understanding trial designs and acceptability of participation in an HIV vaccine trial with concurrent randomisation to oral pre-exposure prophylaxis in East and Southern Africa: a longitudinal qualitative study.

randomized controlled trial · 2026 · PMID 42141483

Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial.

randomized controlled trial · 2026 · PMID 42414619

Evidence Gaps

Detailed risk-of-bias assessment remains limited

PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.

Complete Ranked PubMed Index

The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.

Nursing research · 2026 · PMID 41656685

BACKGROUND: Antiretroviral therapy (ART) is crucial for prolonging the lives of people with human immunodeficiency virus (HIV), but adherence remains suboptimal. Psychosocial interventions show promise for improving ART adherence, yet no consensus exists on the most effective approach. OBJECTIVES: To identify the most effective psychosocial interventions for improving ART adherence in people with HIV. METHODS: Six databases (EMBASE, MEDLINE, Web of Science, CINAHL, PsycINFO, and CENTRAL) were searched from their in…

Rank107.4

Systematic review or meta-analysis

Inflammatory Biomarkers Predicting Major Adverse Cardiovascular Events in People Living With HIV: A Systematic Review and Meta-Analysis.

Journal of the International AIDS Society · 2026 · PMID 42041228

INTRODUCTION: Chronic inflammation is a unique contributor to cardiovascular disease (CVD) risk among people living with HIV, yet there is a lack of consensus on the predictive utility of inflammatory biomarkers in this population. We conducted a systematic review assessing the predictive value of inflammatory biomarkers for major adverse cardiovascular events in people living with HIV to inform their potential integration into CVD risk assessment. METHODS: MEDLINE, Embase and Google Scholar were searched for artic…

Rank105.0

Systematic review or meta-analysis

Metal-artefact-reduction MRI for diagnosing periprosthetic joint infection: a systematic review and meta-analysis.

Skeletal radiology · 2026 · PMID 41792512

BACKGROUND: Periprosthetic joint infection (PJI) remains one of the most serious. Advances in metal-artefact-reduction sequences (MARS) now allow for improved diagnostic quality imaging in the periprosthetic region. Early studies suggest the diagnostic efficacy of MARS, including subfeatures, yet no formal synthesis of available data exists. METHODS: A systematic review and meta-analysis were conducted following PRISMA-DTA and PRISMA 2020 guidelines. Eligible studies include diagnostic accuracy studies reporting MA…

Rank103.4

Systematic review or meta-analysis

Gait analysis methods in people with spinal cord injury: a systematic review.

Journal of neuroengineering and rehabilitation · 2026 · PMID 41821044

BACKGROUND: Spinal cord injury (SCI) leads to impairments in motor, sensory, and autonomic pathways, often resulting in significant disability and reduced quality of life. Recovery of ambulation is a priority for people with SCI and vital for regaining independence and social participation. The increasing incidence of incomplete SCI, especially from non-traumatic causes like degenerative cervical myelopathy, has amplified the clinical relevance of gait recovery. Although gait analysis is widely applied in neurologi…

Rank102.4

Systematic review or meta-analysis

Dysregulated Metabolism in People Living With HIV in the Modern ART-Era: A Systematic Review of Targeted Metabolomics Studies.

Reviews in medical virology · 2026 · PMID 42406562

HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy (ART) suppresses viral replication, it does not eradicate the virus, and metabolic dysregulation persists despite treatment. Metabolomics allows for a detailed investigation of these alterations; however, targeted metabolomics studies in ART-treated PLHIV are limited, and there is no consensus on consistently dys…

Rank102.0

Systematic review or meta-analysis

Towards consensus on the treatment of congenital craniofacial conditions: the discussion section of a doctoral thesis.

Journal of plastic surgery and hand surgery · 2026 · PMID 42095487

BACKGROUND: Congenital craniofacial conditions are a diverse group of rare and complex disorders, leading to significant functional and psychosocial challenges. Their rarity and variability hinder research and clinical standardisation, resulting in substantial practice variation across centres. International collaboration and high-quality evidence are therefore essential to improve and converge care for affected individuals. This article presents the discussion section of a doctoral thesis that addressed these chal…

Rank98.0

Systematic review or meta-analysis

Availability, acceptability and adoption of decision aids for HIV prevention and contraception for young people: a scoping review protocol.

BMJ open · 2026 · PMID 41781051

INTRODUCTION: Young people face challenges in accessing information on HIV and sexual and reproductive health services, with corresponding suboptimal uptake. Decision aids can provide information and decisional support to improve young people's engagement with health interventions. However, they have not been widely implemented among young people. The availability of different choices for HIV and pregnancy prevention means that it is important to implement interventions that facilitate informed choices for these me…

Rank98.0

Systematic review or meta-analysis

[Cochlear implantation in Ménière's disease].

HNO · 2026 · PMID 41644838

Menière's disease is a chronic inner ear disorder characterized by recurrent vertigo attacks, tinnitus, and fluctuating hearing loss, which may progress to severe sensorineural hearing impairment in a subset of patients. Since 2015, international consensus criteria distinguish between definite and probable disease. Current therapeutic strategies follow a stepwise approach, ranging from non-ablative to ablative interventions. Cochlear implantation (CI) has emerged as an effective option for auditory rehabilitation a…

Rank97.2

Randomized controlled trialResult signal: null

Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

Age and ageing · 2026 · PMID 42407092

BACKGROUND: Frailty and sarcopenia contribute to functional decline in older people with HIV (PWH), yet intervention data remain limited. We evaluated changes in frailty phenotype status, sarcopenia-related outcomes and functional performance during a supervised exercise trial and assessed associations between baseline frailty, study withdrawal and intervention response. METHODS: The High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults with HIV (HEALTH) study randomised sedentary PWH ag…

Rank85.0

Randomized clinical study

Methamphetamine use and HIV prevention: a qualitative study on challenges and opportunities for PrEP utilization.

AIDS care · 2026 · PMID 41498432

Methamphetamine use often co-occurs with sexual behaviors that may increase HIV acquisition risk and disrupt adherence to HIV pre-exposure prophylaxis (PrEP). To explore barriers and opportunities for PrEP among people who use methamphetamine, we conducted semi-structured interviews with 28 self-reported HIV-negative adults (ages 18-55) with current moderate-to-high risk methamphetamine use in the New York City metropolitan area. Transcripts were thematically analyzed with double coding and iterative consensus. Par…

Rank85.0

Randomized clinical study

Operational strategies among infectious disease clinical trial sites during pandemics: a scoping review.

Trials · 2026 · PMID 41943131

PURPOSE: The aim of this study is to examine documented strategies, challenges, and lessons related to clinical trial site operations during pandemics. METHODS: This review focused on seven major pandemics: COVID-19, HIV/AIDS, Ebola, SARS, MERS, H1N1, and Zika. Searches were conducted using PubMed and Embase between September 2024 and February 2025, yielding 7572 unique records. After dual screening, 47 articles met inclusion criteria, with an additional 8 identified through citation searching, for a total of 55. N…

Rank75.6

Multicenter clinical study

Determinants of long-acting cabotegravir plus rilpivirine discontinuation in real-world HIV care: insights from the relativity cohort.

AIDS (London, England) · 2026 · PMID 41805169

OBJECTIVES: To evaluate real-world persistence with long-acting cabotegravir plus rilpivirine (CAB+RPV LA) in a nationwide cohort of virologically suppressed adults, describe the main clinical and structural reasons for discontinuation, and identify predictors of early interruption in routine practice. DESIGN: Ambispective, multicenter cohort study assessing the durability, safety, adherence, and virological outcomes of CAB+RPV LA implementation across 58 Spanish healthcare settings. METHODS: Adults initiating CAB+…

Rank53.6

Other PubMed-indexed publication

Nomogram model for predicting incomplete immune reconstitution in people living with HIV based on clinical characteristics.

Frontiers in immunology · 2026 · PMID 41846935

BACKGROUND: Despite the success of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) in China, immune non-response (INR) remains critical for the long-term quality of life of people living with HIV (PLWH). Although the consensus on diagnosis and management of immunological non-responders in HIV infection (Version 2023) was published in China to standardize diagnostic criteria, prediction models for INR based on these criteria remain scarce. This study aims to develop and validate a nomogram model …

Rank52.6

Other PubMed-indexed publication

Real-world lymphoma cohort in an HIV-endemic setting: cohort design, epidemiological features and impact of implementing novel classification standards.

BMC cancer · 2026 · PMID 41928152

BACKGROUND: Lymphoma real-world observational data and accurate diagnostic systems are lacking in low-resource HIV-endemic settings. We established a new lymphoma registry to generate internationally comparable, clinically validated data, with up-to-date disease classification. We also describe our findings on aggressive B-cell lymphoma. METHODS: The descriptive retrospective cohort included patients ≥ 13 years of age newly diagnosed with lymphoma from 2005 to 2020. Patients were enrolled at a single site in a regi…

Rank50.7

Other PubMed-indexed publication

The impact of accumulating immune adaptation in circulating strains of HIV-1.

HIV medicine · 2026 · PMID 41795223

BACKGROUND: Mutations in human immunodeficiency virus type 1 (HIV-1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)-restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele-HIV sequence associations at the population level. Most studies of HLA associations have been cross-sectional and may not capture selective changes that have accumulated to reach fixation at the population level, with potential impacts on v…

Rank50.1

Other PubMed-indexed publication

Profile of SARS-CoV-2/HIV-1 coinfection in patients from the extreme south of Brazil.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026 · PMID 41811606

The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in millions of infections and deaths. Studies describing the pathophysiology and characterizing the outcome of the disease in specific populations, including those living with HIV, are necessary. There is no consensus on whether the disease worsens in immunosuppressed patients, which is considered a risk factor, or if immunosuppression might confer protection against cytokine storms. This retrospective descriptive study reports on the profile of SARS-CoV-2/H…

Rank49.8

Other PubMed-indexed publication

Comparative evaluation of multimodal large language models for diagnostic accuracy in pediatric electrocardiography: a prospective comparative diagnostic accuracy study.

European journal of pediatrics · 2026 · PMID 41872525

UNLABELLED: We evaluated three multimodal LLMs, ChatGPT (GPT-5.2), Gemini 3, and Microsoft Copilot, in pediatric ECG interpretation, focusing on clinically significant abnormalities and emergency arrhythmias with likelihood ratios as primary outcome measures. This prospective comparative diagnostic accuracy study (STARD/STARD-AI) included 264 pediatric patients with 12-lead ECGs (November 2024-November 2025). De-identified images were submitted via standardized zero-shot prompt. Three blinded pediatric cardiologist…

Rank49.1

Other PubMed-indexed publication

Hypophosphatasia: low penetrance of pathogenic and likely-pathogenic ALPL variants identified through an unselected biorepository.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026 · PMID 41269245

Hypophosphatasia (HPP) is a heritable multisystem disorder caused by pathogenic variants in the tissue nonspecific alkaline phosphatase (ALP)-coding gene ALPL. The genotype-phenotype correlation in heterozygous adults with HPP remains incompletely understood. In this genotype-based study, we aimed to measure the prevalence of pathogenic or likely-pathogenic ALPL variants and to test the hypothesis that HPP penetrance is low in adult carriers. A total of 37 147 genomes from unselected individuals visiting a tertiary…

Diagnosis And Screening117 records

Rank110.2

Systematic review or meta-analysis

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

The Cochrane database of systematic reviews · 2025 · PMID 40492485

Rank107.7

Systematic review or meta-analysis

The relationship between digit ratio (2D:4D) and autoimmune diseases: A systematic review and meta-analysis.

Early human development · 2026 · PMID 42034071

OBJECTIVE: To explore the association between the second-to-fourth digit ratio (2D:4D) and autoimmune diseases (AIDs). METHODS: Relevant studies were retrieved from multiple databases up to October 2025. The 2D:4D ratio of both hands (2D:4D R + L), right hand minus left hand (ΔR - L 2D:4D), right hand (2D:4D R), left hand (2D:4D L), and Type 3 finger pattern (index finger shorter than the ring finger) were extracted. The pooled standardized mean difference (SMD) and odds ratio (OR) with their respective 95% confide…

Rank101.6

Systematic review or meta-analysis

Cervical length surveillance for predicting spontaneous preterm birth in women with congenital uterine anomalies: A systematic review and diagnostic accuracy meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology · 2026 · PMID 42541967

BACKGROUND: The role of transvaginal cervical length surveillance in predicting spontaneous preterm birth (sPTB) in women with congenital uterine anomalies (CUA) remains unclear. This study is a systematic review and diagnostic accuracy meta-analysis of its predictive value in this population. METHODS: A literature review of MEDLINE, EMBASE and Cochrane Library was conducted from inception to December 2025. Observational studies assessing second-trimester cervical length measurement in pregnant women with CUAs were…

Rank100.0

Systematic review or meta-analysis

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

The Cochrane database of systematic reviews · 2024 · PMID 39908067

This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity automated nucleic acid amplification tests on respiratory samples versus each test alone for detection of tuberculosis disease in adults and adolescents living with HIV who present with presumptive tuberculosis. Secondary objectives To investigate the following sources of heterogeneity: clinical setting; signs and…

Rank100.0

Systematic review or meta-analysis

Magnitude and factors associated with diabetes mellitus among people living with HIV/AIDS in Eastern Africa. Evidence from Ethiopia, Kenya, Uganda and Tanzania. A systematic review and meta-analysis.

Endocrine · 2026 · PMID 42541631

BACKGROUND: The introduction of combination antiretroviral therapy (cART) has improved survival among people living with HIV (PLHIV) but increased the risk of non-communicable diseases, including diabetes mellitus (DM). In East Africa, estimates of DM prevalence among PLHIV vary widely, and contributing factors are not well defined. This study aimed to estimate the pooled prevalence of DM and identify associated risk factors among PLHIV in the region. METHODS: A systematic review and meta-analysis were conducted fo…

Rank99.3

Randomized controlled trialResult signal: null

Efficacy and safety of the Chinese herbal medicine Yiaikang capsule in treating AIDS: a randomized, double-blind, controlled trial.

Journal of ethnopharmacology · 2026 · PMID 41967778

ETHNOPHARMACOLOGICAL RELEVANCE: The Shuyu pill is a traditional Chinese medicine (TCM) formula, used to treat Xu Lao for over 1800 years. Studies have reported the effectiveness of Yiaikang capsules (YAK), a modified form of Shuyu pills, in AIDS treatment. However, clinical evidence for the management of AIDS using YAK is lacking. We aimed to evaluate the efficacy and safety of YAK combined with antiretroviral therapy (ART) among people living with HIV infection. MATERIALS AND METHODS: We conducted a randomized, do…

Rank98.6

Systematic review or meta-analysisResult signal: harm

HIV and Human Papilloma Virus Community Service Integration Among Women: A Systematic Review and Narrative Synthesis.

The Journal of the Association of Nurses in AIDS Care : JANAC · 2026 · PMID 42460889

Cervical cancer (CC) is a leading cause of death, with women with HIV at an increased risk. Geographic disparities in CC and HIV reflect inequities in care access. The purpose of this systematic review was to evaluate integrated models for HIV and CC screening. This review was conducted following PRISMA guidelines. Full-text screening and data extraction were conducted independently. Eligible studies described integrated HIV and CC services. Of 4,280 records, 24 met inclusion criteria. Most studies ( n = 21) were c…

Rank98.0

Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

CONTEXT: Advanced care planning (ACP) can reduce hospitalizations, increase quality of life, and align treatment with patient wishes, while lowering healthcare costs. However, healthcare providers' discomfort, lack of training, and patient anxiety may hinder ACP. Furthermore, disparities exist among minority and low-income groups. Growing research highlights the need for standardized definitions and broader implementation, especially post-COVID-19, incorporating digital tools, economic impacts, ethics, and family r…

Rank96.0

Randomized controlled trial

A 3-month clofazimine-rifapentine-containing regimen for drug-susceptible tuberculosis versus standard of care (Clo-Fast): a randomised, open-label, phase 2c clinical trial.

The Lancet. Infectious diseases · 2026 · PMID 40915311

BACKGROUND: Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine loading dose, to the standard 6 month regimen of isoniazid, rifampicin,…

Rank96.0

Systematic review or meta-analysis

Feeding the gut-immune axis: dietary, prebiotic, and probiotic strategies to target persistent inflammation in ART-treated HIV: a narrative review.

Frontiers in immunology · 2026 · PMID 42539524

People living with HIV (PWH) experience ongoing systemic inflammation driven by gut dysbiosis, epithelial barrier disruption, and microbial translocation, despite antiretroviral therapy (ART). This review examines evidence from randomized controlled trials, mechanistic studies, systematic reviews, and meta-analyses evaluating nutritional and microbiome-based interventions to reduce inflammation in PWH. Reduced production of short-chain fatty acids (SCFAs) by the gut microbiota has been observed to precede morbidity…

Rank95.0

Randomized controlled trial

Prevalence of neurotoxicity symptoms among postpartum women on isoniazid preventive therapy and efavirenz-based treatment for HIV: an exploratory objective of the IMPAACT P1078 randomized trial.

BMC pregnancy and childbirth · 2023 · PMID 36650479

BACKGROUND: This exploratory analysis investigates the prevalence and risk factors of neurocognitive toxicity in postpartum women on HIV treatment in response to a concern of an Isoniazid Preventive Therapy (IPT)/Efavirenz interaction. TRIAL DESIGN: Pregnant women on HIV treatment from countries with high TB prevalence were randomized in IMPAACT P1078 to 28 weeks of IPT started either during pregnancy or at 12 weeks postpartum. Partway through study implementation, the Patient Health Questionnaire 9, the cognitive …

Rank93.6

Randomized clinical study

Voluntary HIV Testing and Counselling Initiatives in Occupational Settings: A Scoping Review.

International journal of environmental research and public health · 2025 · PMID 40003488

Voluntary HIV testing and counselling (VCT) in the workplace could reach population groups who may be at risk for HIV but may not readily seek out testing from other services. We conducted a scoping review to understand (a) the nature of evidence related to initiatives and interventions for vocationally active adults on VCT in occupational settings, and (b) any facilitators and barriers to the delivery of and/or engagement with VCT initiatives/interventions in the workplace. JBI scoping review methodology was follo…

Rank93.0

Systematic review or meta-analysis

Evidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review.

PloS one · 2022 · PMID 35709211

BACKGROUND: At the end of 2019, there were about 2.8 million children and adolescents aged 0-19 living with HIV. In contrast to pregnant women and adults, service delivery for children and adolescents living with HIV continues to lag behind with regard to access to care, components of care delivery, treatment options, and clinical and immunologic outcomes. AIM: The aim of this systematic review is to synthesize the evidence on the most effective interventions, models, programs, and strategies to optimize the delive…

Rank89.0

Randomized controlled trial

Timing of maternal isoniazid preventive therapy on tuberculosis infection among infants exposed to HIV in low-income and middle-income settings: a secondary analysis of the TB APPRISE trial.

The Lancet. Child & adolescent health · 2023 · PMID 37634517

BACKGROUND: Infants born to women with HIV in settings with a high tuberculosis burden are at risk of tuberculosis infection and rapid progression to active disease. Maternal isoniazid preventive therapy might mitigate this risk, but optimal timing of therapy remains unclear. The TB APPRISE trial showed that initiation of isoniazid during pregnancy resulted in more frequent adverse pregnancy outcomes than when initiated postpartum. We aimed to determine the proportion of infants testing positive for tuberculosis in…

Rank86.9

Randomized clinical study

Effect of the relationship between anaemia and systemic inflammation on the risk of incident tuberculosis and death in people with advanced HIV: a sub-analysis of the REMEMBER trial.

EClinicalMedicine · 2023 · PMID 37287871

BACKGROUND: Tuberculosis (TB) is an infectious morbidity that commonly occurs in people living with HIV (PWH) and increases the progression of HIV disease, as well as the risk of death. Simple markers of progression are much needed to identify those at highest risk for poor outcome. This study aimed to assess how baseline severity of anaemia and associated inflammatory profiles impact death and the incidence of TB in a cohort of PWH who received TB preventive therapy (TPT). METHODS: This study is a secondary postho…

Rank86.8

Randomized clinical study

Protocol for an attention-matched randomized controlled trial of 2GETHER: a relationship education and HIV prevention program for young male couples.

Trials · 2022 · PMID 35725624

BACKGROUND: Young men who have sex with men (YMSM) are disproportionately impacted by the HIV epidemic in the USA, and a large number of new infections among YMSM occur in the context of main or primary partnerships. At the same time, healthy romantic relationships promote health and wellbeing by improving social support and encouraging healthy behaviors. Thus, we created 2GETHER: a relationship education and HIV prevention program for young male couples. 2GETHER is delivered face-to-face in a university setting an…

Rank81.0

Multicenter clinical study

An Interpretable Machine Learning Model for Predicting the Presence of Talaromycosis in HIV Patients Lacking Skin Lesions.

Mycopathologia · 2026 · PMID 42477230

INTRODUCTION: The existing predictive models for talaromycosis in people living with HIV without skin lesions are limited by established risk factors and traditional statistical approaches. This study aims to develop an interpretable machine learning(ML) model for predicting the presence of talaromycosis in HIV patients without skin lesions and to validate its clinical applicability. METHODS: This retrospective multicenter study involved the analysis of electronic medical records from four tertiary hospitals in Chi…

Rank76.3

Multicenter clinical studyResult signal: null

Enhanced detection of low-level viremia by cobas 5800/6800 testing systems: a multi-center evaluation and clinical calibration study in China.

Frontiers in cellular and infection microbiology · 2026 · PMID 42539470

INTRODUCTION: With the advent of more sensitive HIV-1 viral load (VL) testing systems, a greater number of low VL samples can be identified. However, for some patients who were previously virally suppressed, the new testing system may yield discordant results, posing challenges for clinical decision-making. This study systematically evaluated and compared the performance of the cobas 5800/6800 testing systems and the cobas AmpliPrep/cobas TaqMan (CAP/CTM) testing systems. METHODS: The performance of the cobas 5800/…

Rank75.7

Multicenter clinical study

Missed Opportunities for HIV Testing in Hospitalised Adults in Türkiye: Indicator Conditions and Testing Coverage in a National Multicentre Point-Prevalence Survey (HIV-ICs-TR).

Scientific reports · 2026 · PMID 42218185

To quantify the prevalence of HIV testing indications among hospitalised adults in Türkiye, assess HIV testing coverage when clinically indicated, and identify missed diagnostic opportunities in a national multicentre point-prevalence survey. We conducted a national multicentre cross-sectional point-prevalence survey across tertiary referral hospitals from all seven geographical regions of Türkiye. Adult inpatients present at 08:00 on a predefined index day were assessed for predefined HIV testing indications, incl…

Rank73.4

Multicenter clinical study

Identification of pulmonary hypertension with pulmonary vascular surface volume ratio by non-contrast CT.

BMC cardiovascular disorders · 2026 · PMID 42522016

BACKGROUND: The diagnosis of pulmonary hypertension (PH) relies primarily on invasive right heart catheterization (RHC). Although imaging modalities, including echocardiography, computed tomography angiography (CTA) and computed tomography (CT), offer clinical utility, their effectiveness in early detection remains limited. OBJECTIVES: To clarify the relationship between group 1/2 PH and radiomic-morphological features of the pulmonary vasculature derived from non-contrast CT. METHODS: We retrospectively enrolled c…

Rank72.0

Multicenter clinical study

The implementation of tuberculosis preventive therapy in HIV care clinics in Africa, Asia and Latin America: a multiregional site survey.

BMJ global health · 2026 · PMID 41592909

INTRODUCTION: Towards the 'End TB Strategy' targets, the WHO recommends the provision of tuberculosis (TB) preventive therapy (TPT) for high-risk groups including people living with HIV (PLWH). 3 years after the release of the updated 2020 WHO guidelines, we investigated the implementation of TPT services at HIV clinics in low-income and middle-income countries (LMICs), focusing on TB screening, populations eligible for TPT and available TPT regimens. METHODS: In 2023, we surveyed HIV care clinics in the Internatio…

Rank70.9

Prospective cohort study

Indicator condition-guided HIV testing in patients with mononucleosis-like illness and community-acquired pneumonia in an Emergency Department setting: A prospective study from Poland (2015-2018).

PloS one · 2026 · PMID 42525658

BACKGROUND: Despite advances in HIV care, late diagnosis remains a major public health challenge in Europe, with nearly half of HIV diagnoses in the EU/EEA occurring at a late stage. In Poland, a substantial proportion of people living with HIV remain undiagnosed. Indicator condition-guided testing has been proposed as an effective strategy to reduce missed opportunities for earlier diagnosis. METHODS: A prospective cohort study was conducted at the Emergency Department of the Hospital for Infectious Diseases in Wa…

Rank69.0

Prospective cohort study

Contribution of hepatic steatosis to subclinical atherosclerosis progression in people with HIV receiving integrase inhibitors: a 5-year prospective cohort study.

AIDS (London, England) · 2026 · PMID 41921079

BACKGROUND AND OBJECTIVES: Cardiovascular disease (CVD) remains elevated among people with HIV (PWH) despite virological suppression. Whether metabolic-hepatic abnormalities contribute to vascular remodeling during contemporary integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) remains uncertain. We evaluated long-term carotid intima-media thickness (cIMT) trajectories and their metabolic, hepatic, and inflammatory determinants. METHODS AND DESIGN: We conducted a 5-year prospective cohor…

Rank65.0

Prospective cohort study

All-cause and cause-specific mortality trends among people with and without HIV in the Siaya health and demographic surveillance system, Kenya, 2011-2018.

Global health action · 2026 · PMID 41782524

BACKGROUND: All-cause mortality among people with HIV (PWH) in sub-Saharan Africa declined after antiretroviral therapy's introduction, but data in rural settings on evolving causes of death as this population age remain limited. OBJECTIVES: To compare all-cause and cause-specific mortality trends among PWH and people without HIV (PWOH) in western Kenya using a prospective cohort study. METHODS: Data from the Siaya Health and Demographic Surveillance System were used to estimate mortality rates from 2011 to 2018 am…

Rank60.0

Observational or cohort studyResult signal: harm

Metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction.

American journal of physiology. Heart and circulatory physiology · 2026 · PMID 42302383

People with HIV (PWH) remain at increased risk for cardiovascular disease despite sustained viral suppression on antiretroviral therapy, but the biological mechanisms underlying this risk are incompletely understood. We hypothesized that coronary endothelial dysfunction in virally suppressed PWH is associated with specific circulating proteomic signatures reflecting metabolic and redox pathway dysregulation. We conducted a prospective observational study integrating in vivo stress cardiovascular magnetic resonance …

Effectiveness of Digital Health Interventions for Improving Antiretroviral Therapy Outcomes in People With HIV: Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.

Journal of medical Internet research · 2026 · PMID 42490547

BACKGROUND: Digital health interventions (DHIs) are increasingly used to support antiretroviral therapy (ART) management among people living with HIV. However, existing systematic reviews have largely focused on single intervention types or limited outcomes, and few have integrated multiple DHI modalities across both behavioral and clinical end points. Additionally, previous evidence has rarely incorporated analytical approaches, such as prediction intervals (PIs) or trial sequential analysis (TSA), leaving uncerta…

Rank108.4

Systematic review or meta-analysis

The impact of HIV coinfection on mpox patients: a systematic review and meta-analysis.

Emerging microbes & infections · 2026 · PMID 42461714

A substantial proportion of mpox cases occur in people with HIV, but how HIV coinfection and immune status affect clinical outcomes remains unclear. We systematically searched major databases up to March 2025 for observational studies comparing mpox patients with and without HIV coinfection. Pooled effect sizes were calculated using random-effects models. Risk ratios (RRs) or standardized mean differences (SMDs) with 95% confidence intervals were used for dichotomous or continuous outcomes. Post hoc subgroup analys…

Rank108.3

Systematic review or meta-analysis

Exercise for osteoarthritis of the hip.

The Cochrane database of systematic reviews · 2026 · PMID 42486497

RATIONALE: Hip osteoarthritis is a major public health issue. International treatment guidelines recommend exercise to manage symptoms. This is an update of a review first published in 2009 and last updated in 2014. OBJECTIVES: To determine the effects of land-based exercise on pain, physical function, quality of life, participant-reported treatment success, study withdrawals, and adverse events in people with hip osteoarthritis. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, and two trial registries from Fe…

Rank107.7

Systematic review or meta-analysis

The relationship between digit ratio (2D:4D) and autoimmune diseases: A systematic review and meta-analysis.

Early human development · 2026 · PMID 42034071

Rank107.1

Systematic review or meta-analysis

Efficacy and safety of doravirine/islatravir for HIV-1: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

HIV research & clinical practice · 2026 · PMID 42400399

BACKGROUND: The combination of doravirine and islatravir (DOR/ISL) is a novel two-drug regimen for HIV-1. Early development faced challenges due to dose-dependent immunological signals. We aimed to synthesize the evidence on the efficacy and safety of DOR/ISL across all treatment-experience categories, specifically evaluating the impact of islatravir dosage (0.25 mg vs 0.75 mg) on clinical and immunological outcomes. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) …

Rank107.0

Systematic review or meta-analysis

Benchmarking long-acting injectable antiretroviral therapy against real-world oral antiretroviral therapy in southern China: a matching-adjusted indirect comparison of global trial data.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42044724

INTRODUCTION: Long-acting injectable (LAI) antiretroviral efficacy derives largely from Western-centric trials, yet its translation to China's centralized public health model remains unknown. We addressed this gap by benchmarking global trial data against real-world evidence from Southern China. METHODS: We performed a systematic review and meta-analysis (PROSPERO CRD420251249065) of RCTs comparing LAI versus standard oral therapy (SOT), followed by MAIC using individual patient data from a Chinese cohort stratifie…

Rank106.1

Systematic review or meta-analysis

Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019.

Pediatric nephrology (Berlin, Germany) · 2026 · PMID 41649528

INTRODUCTION: Despite major advances in antiretroviral therapy, HIV infection remains a significant global public health challenge. HIV can directly affect the kidneys, leading to HIV-associated nephropathy in children, a condition characterized by proteinuria, elevated serum creatinine, and kidney enlargement. HIV-associated nephropathy is a serious complication that may progress to kidney failure and death. OBJECTIVE: To estimate the prevalence of HIV-associated nephropathy in children. METHODS: We searched PubMe…

Rank105.9

Systematic review or meta-analysis

Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.

Journal of the International Association of Providers of AIDS Care · 2026 · PMID 42538058

BackgroundHIV-associated lipodystrophy, a complication of combined antiretroviral therapy (CART), causes significant physical and psychological distress in people living with HIV (PLWH), compromising treatment adherence. Tesamorelin, a growth hormone-releasing hormone (GHRH) analogue, has emerged as a therapeutic option.ObjectiveTo systematically evaluate the efficacy and safety of tesamorelin in HIV-infected individuals with lipodystrophy receiving CART, incorporating GRADE assessment.MethodsWe searched PubMed, ht…

Rank104.3

Systematic review or meta-analysisResult signal: harm

Syphilis infection and incident dementia in two real-world cohorts: A harmonized propensity-matched analysis in Taiwan NHIRD and TriNetX Asia-Pacific.

Brain, behavior, and immunity · 2026 · PMID 42035811

BACKGROUND: Syphilis is a treatable infection with established neurotropism and broad systemic inflammatory consequences, but population-level evidence linking a history of syphilis to later dementia remains limited. We examined this association across two independent real-world data sources using harmonized analytic methods. METHODS: We conducted retrospective cohort analyses in Taiwan's National Health Insurance Research Database (NHIRD, 2001-2020) and the TriNetX Asia-Pacific electronic health record network (20…

Rank103.7

Systematic review or meta-analysis

Automated Insulin Delivery Systems in Cystic Fibrosis-Related Diabetes: A Systematic Review and Meta-Analysis.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026 · PMID 41933587

OBJECTIVES: To assess the effects of automated insulin delivery systems (AIDs) on glycemic control and selected metabolic and pulmonary outcomes in people with cystic fibrosis related diabetes (pwCFRD). METHODS: We searched MEDLINE (via PubMed), Embase, and Cochrane Library for studies of AIDs in pwCFRD. Eligible studies included at least 14 days of follow-up and reported continuous glucose monitoring outcomes. The primary outcome was time in range (3.9-10.0 mmol/L or 70-180 mg/dL). Additional outcomes included tim…

Rank103.2

Systematic review or meta-analysis

From community engagement to lived experience leadership: a systematic review of HIV services among men who have sex with men.

Health promotion international · 2026 · PMID 42391518

Community responses are essential to achieving the global goal of Ending AIDS by 2030, yet men who have sex with men (MSM) remain underrepresented and often tokenized within HIV initiatives. While community engagement is widely emphasized, far less attention has been given to leadership rooted in lived experience. Meaningful community engagement requires recognizing MSM not merely as a target population, but as leaders shaping HIV responses. This systematic review examines how MSM perceive the use of their lived ex…

Rank103.1

Systematic review or meta-analysis

A Systematic Review of Quantitative Health Preference Methods to Support Value Clarification and Shared Decision Making: A Report of an ISPOR Special Interest Group.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026 · PMID 42000134

OBJECTIVES: This study aimed to explore the design and outcomes of preference-based value clarification methods (Pb-VCMs) used in the context of supporting patients' clinical decision making to understand whether guidance is used in Pb-VCM development and which Pb-VCM is most effective. METHODS: In April of 2023, PubMed, Scopus, and Web of Science were searched for studies reporting the development and/or evaluation of Pb-VCMs without restrictions on publication date. Two reviewers independently extracted data incl…

Rank102.4

Systematic review or meta-analysis

Dysregulated Metabolism in People Living With HIV in the Modern ART-Era: A Systematic Review of Targeted Metabolomics Studies.

Reviews in medical virology · 2026 · PMID 42406562

Rank102.2

Systematic review or meta-analysis

Effects of targeted interventions on HIV testing, knowledge and sexual risk behaviours among long-distance truck drivers: a systematic review and meta-analysis.

BMJ open · 2026 · PMID 42457421

OBJECTIVES: We aimed to systematically summarise and quantify the empirical evidence on targeted interventions and their effects on various HIV prevention outcomes for long-distance truck drivers (LDTDs) globally. DESIGN: A systematic review and meta-analysis. DATA SOURCES: We searched PubMed, PubMed Central (PMC), Cumulated Index to Nursing and Allied Health Literature (CINAHL), ProQuest Central, EBSCOhost, ScienceDirect, World Health Organisation (Global Index Medicus), Cochrane Library, Scientific Electronic Lib…

Rank102.0

Systematic review or meta-analysis

A systematic review of patient decision aids for hypertension.

BMC medical informatics and decision making · 2026 · PMID 42436484

BACKGROUND: Hypertension is a major cause of premature death and a modifiable risk factor for cardiovascular disease. Effective management includes both pharmacological treatment strategies, including antihypertensive medications, and non-pharmacological treatment strategies, such as lifestyle changes. Shared decision making (SDM) between patients and healthcare professionals is essential to determine the most appropriate treatment for hypertension. Patient decision aids (PDAs) facilitate SDM by providing informati…

Rank101.2

Systematic review or meta-analysis

Maternal-to-Child-Transmission of Human Immunodeficiency Virus in Maternal Preterm Premature Rupture of the Membranes: A Systematic Review.

The journal of obstetrics and gynaecology research · 2026 · PMID 42409579

AIM: Preterm premature rupture of membranes (PPROM) in the context of maternal human immunodeficiency virus (HIV) infection poses a significant clinical dilemma, as clinicians must balance the risks of prematurity with the risks of delaying delivery and potentially increasing the chance of mother-to-child transmission (MTCT) of HIV. This review aimed to identify the rate of MTCT in HIV-positive pregnant individuals with PPROM and assess neonatal outcomes. METHODS: A systematic search strategy following PRISMA guide…

Rank100.0

Systematic review or meta-analysis

Risk and protective factors associated with depressive symptoms in older adults with visual impairment: a systematic review.

The Gerontologist · 2026 · PMID 42287712

BACKGROUND AND OBJECTIVES: This systematic review aimed to synthesize risk and protective factors associated with depressive symptoms in older adults with visual impairment. RESEARCH DESIGN AND METHODS: We included quantitative studies that examined factors associated with depressive symptoms in adults aged 60 or older with visual impairment. Five electronic bibliographic databases (PubMed, Web of Science, Embase, PsycINFO, and CINAHL Complete) were searched in November 2025 in collaboration with medical librarians…

Rank100.0

Systematic review or meta-analysisResult signal: null

Fast-Acting Caffeine: Does Caffeinated Chewing Gum Enhance Muscular Strength, Endurance, and Jumping Performance? A Systematic Review and Meta-Analysis.

Journal of strength and conditioning research · 2026 · PMID 42228847

Varovic, D and Grgic, J. Fast-acting caffeine: Does caffeinated chewing gum enhance muscular strength, endurance, and jumping performance? A systematic review and meta-analysis. J Strength Cond Res 40(8): 1020-1029, 2026-Caffeine delivered through chewing gum is rapidly absorbed, making it a practical ergogenic aid for athletes. We aimed to conduct a systematic review and a multilevel meta-analysis exploring the effects of caffeinated chewing gum on muscular strength, endurance, and jump height. We searched 4 datab…

Landmark Evidence64 records

Rank110.2

Systematic review or meta-analysis

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

The Cochrane database of systematic reviews · 2025 · PMID 40492485

Rank110.0

Systematic review or meta-analysis

Effects of hearing aid use on memory, executive function, and cognitive impairment among older adults with hearing loss: a systematic review and meta-analysis.

The journals of gerontology. Series B, Psychological sciences and social sciences · 2026 · PMID 41803081

Rank108.5

Systematic review or meta-analysis

What is polypharmacy in people living with HIV/AIDS? A systematic review.

AIDS research and therapy · 2022 · PMID 35918746

Polypharmacy in people living with HIV/AIDS (PLWHA) is a rising morbidity that exacts hefty economic burden on health budgets in addition to other adverse clinical outcomes. Despite recent advances, uncertainty remains around its exact definition in PLWHA. In this systematic review and Meta-analysis, we explored relevant databases (PUBMED, EMBASE, CROI) for studies evaluating polypharmacy in PLWHA from January 2000 to August 2021 to ascertain the exact numerical threshold that defines this morbidity. Two independen…

Rank107.3

Systematic review or meta-analysis

Antiviral therapy for cytomegalovirus retinitis: A systematic review and meta-analysis.

Survey of ophthalmology · 2025 · PMID 39549781

Cytomegalovirus retinitis (CMVR) is a significant cause of blindness in patients with advanced acquired immunodeficiency syndrome (AIDS). There are no established guidelines for its treatment, resulting in varied antiviral approaches. We pooled data from 59 studies (4501 patients) to evaluate treatment variations and outcomes (CRD42022321088). Overall pooled estimates showed visual acuity improvement at 18 % (95 % CI: 7-41 %), inflammation resolution at 90 % (95 % CI: 81-95 %), retinal detachment at 11 % (95 % CI: …

Rank107.0

Systematic review or meta-analysisResult signal: harm

Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies.

Journal of acquired immune deficiency syndromes (1999) · 2021 · PMID 33492019

OBJECTIVES: To systematically analyze available prospective evidence on the association between HIV infection and incident heart failure (HF). METHODS: A systematic search of PubMed, EMBASE, Web of Science, and manual search of relevant articles through June 1st, 2020, was conducted. Two authors independently performed full-text assessments and data extraction. The pooled relative risk with 95% confidence interval was estimated using DerSimonian and Laird random-effects models, with inverse-variance fixed-effects m…

Rank105.9

Systematic review or meta-analysis

Endocrine · 2026 · PMID 42541631

Rank100.0

Systematic review or meta-analysis

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

The Cochrane database of systematic reviews · 2024 · PMID 39908067

Rank100.0

Systematic review or meta-analysis

HIV infection and esophageal cancer in Sub-Saharan Africa: a comprehensive meta-analysis.

AIDS reviews · 2024 · PMID 38530745

Africa hosts the highest burden of esophageal cancer (49%) and HIV (60%) worldwide. It is imperative to investigate the synergistic impact of these two diseases on African populations. This study conducted an exhaustive computerized search of databases, including Medline/PubMed, Embase, Web of Science, Scopus, Cochrane library, and African Journals Online, to identify eligible studies up to October 2023. HIV infection was the exposure, esophageal cancer risk was the outcome, and healthy subjects with no cancer hist…

Rank99.8

Systematic review or meta-analysis

Factors associated with pyomyositis: A systematic review and meta-analysis.

Tropical medicine & international health : TM & IH · 2021 · PMID 34407271

OBJECTIVES: Pyomyositis, an acute bacterial infection of skeletal muscle usually resulting in abscess formation, is well recognised in tropical regions where it can account for up to 4% of adult surgical admissions. It is increasingly being reported from high-income temperate countries. Pyomyositis occurs across all ages and in both sexes. Mortality ranges from 1% to 23%. Many risk factors have been suggested. We aimed to identify factors associated with pyomyositis. METHODS: We undertook a systematic review and me…

Rank99.6

Systematic review or meta-analysisResult signal: harm

Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis.

Journal of infection and public health · 2022 · PMID 35617829

BACKGROUND: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. METHODS: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Ana…

Rank99.6

Randomized controlled trial

Statin effects on the incidence of major non-cardiovascular disease events among a global cohort of people with HIV: a randomised controlled trial.

The lancet. HIV · 2025 · PMID 40180472

BACKGROUND: Given the pleiotropic effects of statins beyond lipid-lowering, statins might positively impact other, non-cardiovascular diseases (non-CVDs). In this study, we prospectively assessed statin effects on non-CVD events and their incidence among people with HIV globally. METHODS: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE; ClinicalTrials.gov, NCT02344290) was a randomised, placebo-controlled trial of pitavastatin for CVD prevention took place from 2015 to 2023 at 145 research sites in…

Most Effective Evidence Supported Treatments85 records

Rank110.2

Systematic review or meta-analysis

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

The Cochrane database of systematic reviews · 2025 · PMID 40492485

Rank110.0

Systematic review or meta-analysisResult signal: harm

Factors associated with tuberculosis patient delay: a meta-analysis.

Frontiers in public health · 2026 · PMID 42523815

Rank110.0

Systematic review or meta-analysis

Effects of hearing aid use on memory, executive function, and cognitive impairment among older adults with hearing loss: a systematic review and meta-analysis.

The journals of gerontology. Series B, Psychological sciences and social sciences · 2026 · PMID 41803081

Rank110.0

Clinical guideline or consensus statement

British Association of Sexual Health and HIV guidelines on the management of viral hepatitis 2026.

International journal of STD & AIDS · 2026 · PMID 42117446

Rank109.1

Systematic review or meta-analysis

Factors associated with mortality and recurrence among patients with multidrug-resistant tuberculosis (MDR-TB): a systematic review, meta-analysis and meta-regression.

Infectious diseases (London, England) · 2026 · PMID 42017750

Rank108.7

Systematic review or meta-analysis

Effectiveness of Digital Health Interventions for Improving Antiretroviral Therapy Outcomes in People With HIV: Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.

Journal of medical Internet research · 2026 · PMID 42490547

Rank108.3

Systematic review or meta-analysis

Exercise for osteoarthritis of the hip.

The Cochrane database of systematic reviews · 2026 · PMID 42486497

Rank107.1

Systematic review or meta-analysis

Efficacy and safety of doravirine/islatravir for HIV-1: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

HIV research & clinical practice · 2026 · PMID 42400399

Rank106.1

Systematic review or meta-analysis

Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019.

Pediatric nephrology (Berlin, Germany) · 2026 · PMID 41649528

Rank105.9

Systematic review or meta-analysis

Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.

Journal of the International Association of Providers of AIDS Care · 2026 · PMID 42538058

Rank103.2

Systematic review or meta-analysis

From community engagement to lived experience leadership: a systematic review of HIV services among men who have sex with men.

Health promotion international · 2026 · PMID 42391518

Rank102.4

Systematic review or meta-analysis

Dysregulated Metabolism in People Living With HIV in the Modern ART-Era: A Systematic Review of Targeted Metabolomics Studies.

Reviews in medical virology · 2026 · PMID 42406562

Rank102.0

Systematic review or meta-analysis

Patient education and counseling · 2026 · PMID 41570487

Rank100.0

Systematic review or meta-analysis

Cancer medicine · 2024 · PMID 38741546

Rank100.0

Systematic review or meta-analysisResult signal: harm

Integrating smoking cessation into HIV care settings: A systematic review and meta-analysis of effectiveness and the evidence gap in cost-effectiveness.

PloS one · 2026 · PMID 42531253

The prevalence of smoking among people living with HIV (PLWH) is higher than in the general population, and PLWH who smoke are at increased risk of both smoking- and HIV-related comorbidities. As most PLWH reside in low- and middle-income countries (LMICs), there is a need for effective and cost-effective smoking cessation interventions in resource-constrained settings. We systematically reviewed and meta-analyzed the effectiveness of smoking cessation interventions for PLWH and looked for economic evaluations. Fou…

Rank100.0

Systematic review or meta-analysis

Implementation of therapeutic adherence in adult patients diagnosed with the Human Immunodeficiency Virus: A systematic review.

Patient education and counseling · 2026 · PMID 42155336

OBJECTIVES: To systematically map and summarize the available knowledge on interventions that promote medication adherence among adult HIV patients and to describe the current state of the art regarding the impact of these interventions on clinical and psychosocial outcomes. METHODS: A systematic search was conducted and two researchers screened eligible studies independently. The Joanna Briggs Institute Quality Appraisal for Randomized Controlled Trials, Cross-Sectional Studies, and Quasi-Experimental Studies were…

Rank100.0

Systematic review or meta-analysis

Integrated Care Models for HIV, Diabetes and Hypertension in Sub-Saharan Africa: A Systematic Review of Effectiveness, Implementation and Real-World Applicability.

Journal of the International AIDS Society · 2026 · PMID 42402976

BACKGROUND: Sub-Saharan Africa faces a syndemic of HIV and non-communicable diseases (NCDs), particularly diabetes and hypertension. Integrated care models have been promoted to improve service efficiency and patient outcomes; however, evidence on their effectiveness, implementation and real-world applicability remains fragmented. OBJECTIVE: This systematic review aimed to assess the clinical and service delivery effectiveness of integrated HIV-diabetes-hypertension care models in sub-Saharan Africa and to identify…

New Research Last 24 Months264 records

Rank110.2

Systematic review or meta-analysis

Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.

The Cochrane database of systematic reviews · 2025 · PMID 40492485

Rank110.0

Systematic review or meta-analysis

Effects of hearing aid use on memory, executive function, and cognitive impairment among older adults with hearing loss: a systematic review and meta-analysis.

The journals of gerontology. Series B, Psychological sciences and social sciences · 2026 · PMID 41803081

Rank108.4

Systematic review or meta-analysis

The impact of HIV coinfection on mpox patients: a systematic review and meta-analysis.

Emerging microbes & infections · 2026 · PMID 42461714

Rank107.1

Systematic review or meta-analysis

Efficacy and safety of doravirine/islatravir for HIV-1: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

HIV research & clinical practice · 2026 · PMID 42400399

Rank105.9

Systematic review or meta-analysis

Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.

Journal of the International Association of Providers of AIDS Care · 2026 · PMID 42538058

Rank101.6

Systematic review or meta-analysis

Cervical length surveillance for predicting spontaneous preterm birth in women with congenital uterine anomalies: A systematic review and diagnostic accuracy meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology · 2026 · PMID 42541967

Rank100.0

Systematic review or meta-analysis

Prevalence and risk of cardiovascular events among people living with HIV: a meta-analysis.

Annals of medicine · 2026 · PMID 42478138

Rank100.0

Systematic review or meta-analysis

Youth-friendly health services for tuberculosis care: an integrative review and implementation science synthesis.

BMC health services research · 2026 · PMID 42271397

The lancet. HIV · 2025 · PMID 41314741

BACKGROUND: There is a high unmet need for effective HIV prevention options, including vaccines, for individuals at high risk of HIV acquisition who choose not to use pre-exposure prophylaxis or other prevention strategies. This study evaluated the efficacy and safety of an HIV-1 vaccine regimen consisting of tetravalent mosaic adenovirus serotype 26-based vaccine (Ad26.Mos4.HIV) and bivalent clade C glycoprotein (gp) 140-mosaic gp140 vaccine, in a population with high seroincidence. METHODS: This randomised, doubl…

Rank98.7

Randomized controlled trial

Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial.

American journal of respiratory and critical care medicine · 2024 · PMID 39012226

Rationale: Optimizing pyrazinamide dosing is critical to improve treatment efficacy while minimizing toxicity during tuberculosis treatment. Study 31/AIDS Clinical Trials Group A5349 represents the largest phase 3 randomized controlled therapeutic trial to date for such an investigation. Objectives: We sought to report pyrazinamide pharmacokinetic parameters, risk factors for lower pyrazinamide exposure, and relationships between pyrazinamide exposure and efficacy and safety outcomes. We aimed to determine pyrazina…

Rank98.6

Randomized controlled trial

Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, implementation and early clinical data.

Journal of the International AIDS Society · 2025 · PMID 40462491

INTRODUCTION: Antiretroviral therapy (ART) prevents and treats, but does not eradicate, HIV. Early ART initiation is associated with post-ART virologic control, particularly among African women, and anti-HIV-1 broadly neutralizing antibodies (bnAbs) may modulate immune responses to HIV. We evaluate whether early ART with or without anti-HIV-1 bnAb VRC01, present at HIV acquisition, is associated with later ART-free control in African women and we assess potential associations with observed control. METHODS: Stakeho…

Rank98.6

Systematic review or meta-analysisResult signal: harm

HIV and Human Papilloma Virus Community Service Integration Among Women: A Systematic Review and Narrative Synthesis.

The Journal of the Association of Nurses in AIDS Care : JANAC · 2026 · PMID 42460889

Rank97.4

Randomized controlled trialResult signal: benefit

Acceptability and safety of one versus three months of rifapentine and isoniazid to prevent tuberculosis in people exposed in the household or workplace in Brazil: The Ultra-Curto randomized controlled trial.

PLoS medicine · 2026 · PMID 41666121

BACKGROUND: Short-course tuberculosis preventive therapy with isoniazid and rifapentine (HP) is widely recommended, but the acceptability and safety of one month of daily HP (1HP) compared to three months of weekly HP (3HP) is uncertain. We compared treatment with these two regimens in people with a positive latent tuberculosis infection test and without HIV infection. We hypothesized that 1HP would have greater treatment completion and fewer targeted safety events than 3HP. METHODS AND FINDINGS: We conducted a Pha…

Rank97.3

Randomized controlled trial

Impact of "absolute" versus "relative" HIV risk communication on pre-exposure prophylaxis interest in Canada: a randomized survey.

AIDS care · 2026 · PMID 41257432

The way human immunodeficiency virus (HIV) acquisition risk is communicated can shape individuals' perceptions and their interest in using pre-exposure prophylaxis (PrEP). This study examined two risk communication strategies among non-PrEP-using gay, bisexual, and other men who have sex with men (GBM) in Canada. In 2022, adult GBMs in Ontario and British Columbia completed an online survey and were randomly assigned to receive HIV risk messages tailored to their risk assessment scores. Messages were framed in eith…

Rank96.0

Systematic review or meta-analysis

Urate dysregulation (hyperuricemia and gout) among people living with HIV: A protocol for a systematic review and meta-analysis.

PloS one · 2026 · PMID 42536647

INTRODUCTION: Approximately 39.9 million people are living with HIV worldwide, most in sub-Saharan Africa. Effective antiretroviral therapy has shifted attention to metabolic comorbidities, and emerging evidence links integrase inhibitors such as dolutegravir to elevated serum uric acid, yet the global burden of hyperuricemia and gout in this population is unquantified. METHODS AND ANALYSIS: This protocol describes a systematic review and meta-analysis of observational studies (cross-sectional, cohort, and case-con…

Rank96.0

Systematic review or meta-analysisResult signal: harm

Beyond Cure: A Scoping Review of Post-Tuberculosis Long-Term Health Outcomes.

Tropical medicine and infectious disease · 2026 · PMID 42506774

BACKGROUND: Tuberculosis (TB) remains a leading cause of global morbidity and mortality, yet its impact extends far beyond microbiological cure. Many TB survivors experience persistent structural lung damage or functional impairment consistent with post-TB lung disease, while growing evidence highlights long-term non-respiratory health outcomes. Synthesizing evidence across lung and non- respiratory health outcomes, along with their risk factors, is critical to inform long-term TB care. METHODS: We conducted a scop…

Rank96.0

Randomized controlled trial

Contact dermatitis · 2026 · PMID 42535430

Henna has traditionally been considered safe as a natural dye for hair, skin and nails. However, recent reports of dermatitis are increasing. While often linked to para-phenyldiamine (PPD) additives, allergic reactions to pure henna are also emerging. This review aims to provide a focused clinical overview of allergic contact dermatitis (ACD) caused specifically by pure henna. We performed a systematic review of studies reporting on cases of ACD to pure henna. We searched PubMed, SCOPUS and Web of Science without t…

Preclinical Research66 records

Rank96.0

Randomized controlled trial

A 3-month clofazimine-rifapentine-containing regimen for drug-susceptible tuberculosis versus standard of care (Clo-Fast): a randomised, open-label, phase 2c clinical trial.

The Lancet. Infectious diseases · 2026 · PMID 40915311

Rank94.4

Randomized controlled trial

Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, VRC07-523LS, and PGT121.414.LS infused intravenously or subcutaneously (HVTN 140/HPTN 101 part B): a phase 1, randomised trial.

The lancet. HIV · 2026 · PMID 42114530

BACKGROUND: Passive immunisation with a combination of broadly neutralising monoclonal antibodies (mAbs) presents a potential HIV-1 prevention modality. This study (HVTN 140/HPTN 101) sought to evaluate PGDM1400LS (targeting V3-glycan) administered alone (part A, previously reported), and in combination (part B) with VRC07-523LS (targeting CD4 binding site) and PGT121.414.LS (targeting V2-apex) in healthy adults without HIV-1. METHODS: The study was a phase 1, multicentre, randomised, open-label trial done across t…

Rank73.4

Multicenter clinical study

Molecular therapy : the journal of the American Society of Gene Therapy · 2026 · PMID 41832601

Here, we present an HIV gene therapy strategy by in vivo precision gene editing in hematopoietic stem cells (HSCs). We successfully generated a panel of helper-dependent adenoviral vectors expressing all-in-one base editors (HDAd-BEs) targeting the CCR5 gene. In an HIV-permissive cell line, transduction with the HDAd-BE vector led to near-complete target site editing, CCR5 knockout, and inhibition of HIV infection. In HSC-enriched human CD34+ cells from mobilized donors or cord blood, we measured efficient precisio…

Promising Experimental Therapies62 records

Rank107.4

Systematic review or meta-analysis

The Effectiveness of Artificial Intelligence in Undergraduate Health Professions Education: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR medical education · 2026 · PMID 42085678

BACKGROUND: Health professions education faces increasing challenges from rising health care complexity, pedagogical shifts, and constrained curricular space, and rapidly expanding knowledge and technological advances. While artificial intelligence (AI) shows promise for transforming health professions education, evidence of its effectiveness remains unclear. OBJECTIVE: This study synthesized evidence from randomized controlled trials (RCTs) on the effectiveness of AI in undergraduate health professions education. …

Rank103.1

Systematic review or meta-analysis

A Systematic Review of Quantitative Health Preference Methods to Support Value Clarification and Shared Decision Making: A Report of an ISPOR Special Interest Group.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026 · PMID 42000134

Rank100.0

Systematic review or meta-analysisResult signal: harm

Integrating smoking cessation into HIV care settings: A systematic review and meta-analysis of effectiveness and the evidence gap in cost-effectiveness.

PloS one · 2026 · PMID 42531253

Rank100.0

Systematic review or meta-analysis

Implementation of therapeutic adherence in adult patients diagnosed with the Human Immunodeficiency Virus: A systematic review.

Patient education and counseling · 2026 · PMID 42155336

Rank98.3

Randomized controlled trial

Islatravir distribution in plasma, peripheral blood mononuclear cells, and mucosal tissues after monthly oral dosing.

AIDS (London, England) · 2026 · PMID 41789892

OBJECTIVE: Islatravir is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) under development for HIV-1 treatment. We aimed to evaluate the pharmacokinetics (PK) of islatravir and its active form, islatravir-triphosphate, in blood and mucosal tissues. DESIGN: This was an exploratory substudy of a randomized, double-blind, placebo-controlled, multicenter, Phase 2a study of once-monthly islatravir in adults at low likelihood of HIV-1 exposure (NCT04003103). METHODS: Participants were randomly assigned…

Rank98.0

Systematic review or meta-analysis

Nature communications · 2026 · PMID 42156721

Glucagon-like peptide-1 (GLP-1) receptor agonists have attracted interest as gerotherapeutics, yet clinical-trial evidence for their effects on biological aging is lacking. We report a post hoc exploratory epigenetic age analysis of a 32-week, randomized, double-blind, placebo-controlled phase 2b trial (NCT04019197) of semaglutide in adults with human immunodeficiency virus (HIV)-associated lipohypertrophy (semaglutide n = 45; placebo n = 39). The parent trial's primary endpoint was change in visceral adipose tissu…

Rank94.4

Randomized controlled trial

Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, VRC07-523LS, and PGT121.414.LS infused intravenously or subcutaneously (HVTN 140/HPTN 101 part B): a phase 1, randomised trial.

The lancet. HIV · 2026 · PMID 42114530

Rank94.0

Randomized controlled trial

Adapting mHealth Interventions to Improve Self-Management of HIV and Reduce Substance Use Among Emerging Adults in Zambia: Protocol for a Randomized Controlled Trial.

JMIR research protocols · 2026 · PMID 42470201

BACKGROUND: Sub-Saharan Africa remains the region most affected by the HIV epidemic, with Zambia experiencing a substantial burden of disease. Young people with HIV are disproportionately impacted. Emerging adulthood (ages 18-24 years) is characterized by increasing independence, risk-taking behaviors, identity exploration, and changing social supports, all of which may impact HIV self-management, including medication adherence and retention in care. Substance use may further undermine HIV outcomes. Innovative inte…

Rank92.0

Randomized controlled trial

Nutrition education has a positive impact on nutritional knowledge, food consumption and body composition in PLHIV: a randomized clinical trial.

Frontiers in public health · 2026 · PMID 42245356

Antiretroviral therapy (ART) has substantially increased the life expectancy of people living with HIV (PLHIV), but its prolonged use has been associated with metabolic alterations that may negatively affect nutritional status. In this context, knowledge about food and nutrition plays a crucial role in promoting healthy food choices and preventing health complications. This study aimed to assess the impact of an intervention with Nutrition education (NE) on nutritional knowledge, food consumption, energy expenditur…

Rank92.0

Randomized controlled trial

Effects of Dietary Nitrate and Caffeine on End Power and Work Above End Power During a 3 min All-Out Test in Trained Male Cyclists.

Nutrients · 2026 · PMID 42124064

BACKGROUND: The purpose of this study was to examine the effects of acute dietary nitrate (NO3-) and caffeine (CAF) supplementation on end power (EP) and work performed above EP (WEP) in trained male cyclists during a 3 min all-out test (3MT) on a cycle ergometer. METHODS: Fifteen healthy, trained male cyclists (28.5 ± 5.3 years, 79.2 ± 9.1 kg, VO2peak 55.2 ± 5.6 mL·kg-1·min-1) completed four exercise trials in a randomized, double-blind, placebo-controlled, crossover study design separated by 3-7 days. The four ex…

Rank92.0

Randomized controlled trial

Acceptability of a Dolutegravir Oral Dispersible Film in Term Neonates Born to Mothers Living With HIV.

Journal of the International AIDS Society · 2026 · PMID 42319215

INTRODUCTION: Dolutegravir (DTG) is a key antiretroviral (ARV) drug for children living with HIV, but no specific formulation is available for neonates (<28 days old). One of the DTG formulations evaluated in the PETITE-DTG trial was a novel 5 mg oral DTG dispersible film (DTG-Film). Acceptability to end-users is essential when introducing new ARV drugs. We report on the experiences of mothers and health workers related to the DTG-Film. METHODS: PETITE-DTG was a phase I/II, open-label two-stage study evaluating the…

Rank88.0

Phase III clinical trial

Baseline and week 48 resistance analysis in participants receiving bictegravir + lenacapavir in the phase 2 ARTISTRY-1 study.

AIDS (London, England) · 2026 · PMID 41874003

BACKGROUND: ARTISTRY-1 is an operationally seamless Phase 2/3 study evaluating the safety and efficacy of once-daily oral lenacapavir (LEN) + bictegravir (BIC) in virologically suppressed participants without known integrase strand-transfer inhibitor (INSTI) resistance, compared to a complex multi-tablet regimen. METHODS: Baseline HIV-1 resistance-associated mutations (RAMs) were assessed via historical genotypic reports (HGR) and proviral DNA genotyping (GenoSure Archive, Monogram Biosciences). The impact of basel…

Rank85.0

Randomized clinical study

A General Framework for Designing and Evaluating Active-Controlled Trials with Non-Inferiority Objectives.

Statistics in medicine · 2026 · PMID 42189090

Active-controlled trials with non-inferiority objectives are often used when effective interventions are available, but new options may offer advantages or meet public health needs. In these trials, participants are randomized to an experimental intervention or an active control. The traditional non-inferiority criterion requires that the new intervention preserve a substantial proportion of the active control effect. A key challenge is the absence of a placebo arm, which necessitates reliance on historical data to…

Rank85.0

Randomized clinical study

Epidemiological yield and cost-effectiveness of non-targeted community HIV screening in a low-prevalence district: a prospective quasi-experimental study.

Frontiers in public health · 2026 · PMID 42523627

OBJECTIVE: To evaluate the epidemiological yield, cost-effectiveness, and mechanisms of diagnostic cascade attrition of active, expanded community-based HIV screening in a low-prevalence region, and to contextualize the regional management burden. METHODS: A prospective, non-randomized, quasi-experimental study was conducted (August-December 2025) across six demographically matched sub-districts. Three implemented active community screening (intervention); three maintained routine facility-based testing (control). …

Rank85.0

Randomized clinical study

Effects of strength training on morphological changes of lipodystrophy in people living with HIV: A quasi-experimental non-randomized controlled trial.

Journal of bodywork and movement therapies · 2026 · PMID 41927229

BACKGROUND: Lipodystrophy syndrome in people living with HIV (PLHIV) is an adverse effect of antiretroviral therapy (ART), characterized by morphological changes that contribute to the social stigma associated with the disease. PURPOSE: The aim of the study was to investigate the effects of a strength training intervention on the morphological changes associated with lipodystrophy in PLHIV. METHODS: This quasi-experimental, non-randomized controlled trial was conducted over 12 weeks with 40 PLHIV (70 % male), divid…

Rank84.2

Phase II clinical trial

Impact of Proviral-DNA M184V/I on 96-Week Outcomes of DTG/3TC Maintenance Therapy: Results From the VOLVER Clinical Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41665101

BACKGROUND: The effect of archived lamivudine resistance mutations in the efficacy of dolutegravir plus lamivudine (DTG/3TC) remains unclear. We evaluated whether proviral-DNA M184V/I detection is associated with virological outcomes in the VOLVER-GESIDA 11820 study. METHODS: This open-label, single-arm, multicenter phase IIa trial (NCT04880785) enrolled virologically suppressed adults with documented or suspected historical lamivudine resistance if the M184V/I mutation was not detected in baseline proviral DNA pop…

Rank79.9

Phase II clinical trial

Maternal and health worker preferences for paediatric antiretroviral formulations in neonates exposed to HIV.

AIDS care · 2026 · PMID 41348547

Oral liquid formulations of zidovudine (ZDV) and nevirapine (NVP) are the main antiretrovirals (ARVs) for neonates born to mothers living with HIV, but they have limitations including poor palatability, short shelf-life, frequent dosing and supply challenges. Understanding caregiver and provider preferences for infant ARV formulations is essential to guide the development of acceptable alternatives. Within the PETITE-DTG trial in South Africa (NCT05590325), evaluating the pharmacokinetics, safety and acceptability …

Rank77.0

Phase II clinical trial

High Isoniazid Exposures When Administered with Rifapentine Once Weekly for Latent Tuberculosis in Individuals with Human Immunodeficiency Virus.

Antimicrobial agents and chemotherapy · 2023 · PMID 36622148

Isoniazid pharmacokinetics are not yet well-described during once weekly, high-dose administrations with rifapentine (3HP) for latent tuberculosis infection (LTBI). Fewer data describe 3HP with dolutegravir-based antiretroviral therapy for the treatment of human immunodeficiency virus (HIV). The only prior report of 3HP with dolutegravir reported elevated isoniazid exposures. We measured the plasma isoniazid levels in 30 adults receiving 3HP and dolutegravir for the treatment of LTBI and HIV. The patients were geno…

Rank68.9

Phase I clinical trial

Exposure-response modeling of QTc interval and creatine kinase-MB in healthy people and treatment-naïve adults living with HIV-1 treated with ainuovirine monotherapy or combined with lamivudine and tenofovir DF.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2026 · PMID 42086178

Prospective Cohort Studies67 records

Rank99.6

Randomized controlled trial

Statin effects on the incidence of major non-cardiovascular disease events among a global cohort of people with HIV: a randomised controlled trial.

The lancet. HIV · 2025 · PMID 40180472

Rank90.7

Randomized clinical study

Feasibility, Acceptability, and Test Performance of Point-of-Care Nucleic Acid Tests for HIV Testing and Viral Load Monitoring in the United States: Prospective Longitudinal Mixed-Methods Study.

JMIR research protocols · 2026 · PMID 42492499

BACKGROUND: With shorter window periods than serologic point-of-care (POC) tests and faster turnaround than laboratory-based nucleic acid tests (NAT), POC NATs could improve early detection of HIV. Furthermore, semiquantitative POC NAT may provide real-time monitoring for persons with HIV. There have been limited evaluations of POC NAT implementation in the United States. OBJECTIVE: This paper describes the protocols and procedures used to evaluate the acceptability and feasibility of POC NAT implementation and tes…

Rank85.0

Randomized clinical study

Quality Of Life65 records

Rank110.0

Clinical guideline or consensus statement

Clinical Practice Guideline for the Diagnosis and Management of Tinnitus in Korea.

Clinical and experimental otorhinolaryngology · 2026 · PMID 42409067

Rank108.3

Systematic review or meta-analysis

Exercise for osteoarthritis of the hip.

The Cochrane database of systematic reviews · 2026 · PMID 42486497

Rank105.9

Systematic review or meta-analysis

Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.

Journal of the International Association of Providers of AIDS Care · 2026 · PMID 42538058

Rank104.2

Systematic review or meta-analysis

Quality of Life in Children With Cochlear Implants: A Systematic Review and Meta-Analysis of Different Quality of Life Domains.

Journal of speech, language, and hearing research : JSLHR · 2026 · PMID 42525886

PURPOSE: The primary objective of this study was to assess the quality of life (QoL) in children with cochlear implants (CIs) from the children's and parents' perspectives through utilizing the Pediatric Quality of Life Inventory (PedsQL) and KINDL questionnaires. A secondary objective was to compare the QoL of children with CIs to those using hearing aids and to children with normal hearing (NH). METHOD: A total of 1,830 records were obtained since the search was systematically carried out across databases, which …

Rank100.0

Systematic review or meta-analysis

Design thinking as health intervention strategy for active aging from 2014 to 2024: A systematic review.

Work (Reading, Mass.) · 2026 · PMID 41761483

BackgroundThe global population is aging rapidly, creating an urgent need to motivate older adults to engage with health interventions despite challenges such as low health literacy, physical and cognitive limitations, perceived stigma, limited resources, and low engagement with new technologies. Design Thinking (DT), a user-centered innovation approach, has been increasingly applied in public health to enhance intervention design and implementation. Systematic reviews on the application of DT in active aging inter…

Rank100.0

Systematic review or meta-analysis

Prevalence and associated factors of ICD/DSM-diagnosed depressive disorders among people living with HIV: A systematic review and meta-analysis.

Journal of affective disorders · 2026 · PMID 41806928

BACKGROUND: Depressive disorders are highly prevalent among people living with HIV (PLWH), severely impairing quality of life and antiretroviral therapy (ART) adherence. While ART advances call for reassessing depressive disorders among PLWH prevalence, most studies rely on self-report tools rather than standardized clinical diagnoses. Linked to HIV stigma, low CD4+ T-cell counts, and ART-related side effects, depressive disorders among PLWH requires targeted prevention and intervention strategies. METHODS: An exte…

Rank98.0

Systematic review or meta-analysisCorrection flagged

Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review.

Archives of gerontology and geriatrics · 2026 · PMID 42085825

Rank98.0

Systematic review or meta-analysis

[Cochlear implantation in Ménière's disease].

HNO · 2026 · PMID 41644838

Rank96.0

Systematic review or meta-analysis

Efficacy of Non-Pharmacological Interventions in Improving Health-Related Quality of Life in People Living With HIV: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.

Worldviews on evidence-based nursing · 2026 · PMID 42503697

BACKGROUND: With antiretroviral therapy, HIV has become a manageable chronic condition, shifting focus to improving health-related quality of life (HRQoL). Non-pharmacological interventions offer distinct advantages for optimizing long-term health outcomes in people living with HIV. OBJECTIVES: To identify optimal non-pharmacological interventions for improving overall HRQoL and its domains (physical, psychological, social, environmental, independence, spiritual). METHODS: Ten databases (Embase, MEDLINE, Web of Sci…

Rank96.0

Systematic review or meta-analysisResult signal: benefit

Shared Decision making aids in palliative care: A systematic review & meta-analysis of randomized controlled trials.

Palliative medicine · 2026 · PMID 42517466

BACKGROUND: Shared Decision Making in palliative care encompassing patient-clinician collaboration has shown potential for improved patient outcomes. However, the impact of decision aids intended to support palliative care decision making discussions across clinical care settings remains uncertain. AIM: To assess the impact of shared of decision aids on decision making, clinical outcomes, and quality of life for patients with palliative care needs and their caregivers. DESIGN: Systematic review and meta-analysis of…

Rank96.0

Systematic review or meta-analysis

Unheard Voices: A Systematic Literature Review of Studies Using Self-Report Methods to Gather the Perspectives of Autistic Adults with Intellectual Disability.

Autism in adulthood · 2026 · PMID 42383261

BACKGROUND: Autistic individuals with intellectual disability remain significantly underrepresented in research, particularly in studies that capture their lived experiences through self-report methods. This systematic review critically examines existing research employing self-report methods in studies where the focus is on autistic adults who have intellectual disability, evaluating the scope of this research, the self-report measures used, and the extent of community involvement. METHODS: We conducted a systemat…

Rank96.0

Systematic review or meta-analysis

Identification and synthesis of decision-making factors in vestibular schwannoma treatment.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 · PMID 41838144

BACKGROUND: Managing vestibular schwannomas (VS) involves complex choices among wait-and-scan, stereotactic radiotherapy, and surgery. Although shared decision-making (SDM) is increasingly emphasized, the factors reported to influence treatment choices remain incompletely characterized. OBJECTIVE: This systematic review aims to synthesize reported factors influencing treatment decision-making in VS and inform SDM practices. METHODS: In accordance with the PRISMA 2020 guidelines, a systematic literature search was c…

Rank96.0

Systematic review or meta-analysis

Effectiveness of Decision Aids for Breast Cancer Treatment: A Systematic Review and Meta-Analysis.

Cancer nursing · 2026 · PMID 42476578

BACKGROUND: Decision aids (DAs) have been developed to support decision-making for breast cancer treatments, but evidence regarding their effectiveness remains inconclusive. OBJECTIVES: To systematically identify and synthesize evidence on the effectiveness of DAs for breast cancer treatment on decision conflict, decision regret, shared decision-making (SDM), quality of life (QoL), health-related quality of life (HRQoL), and surgical choices. METHODS: A systematic search across 9 databases from inception to October…

Rank95.2

Randomized controlled trial

Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.

International journal of antimicrobial agents · 2026 · PMID 42055353

OBJECTIVE: To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsychiatric comorbidities. METHODS: MIND was a phase IV, randomised, double-blind, multicentre trial. Participants were assigned (1:1) to switch to BIC/FTC/TAF or continue DTG/3TC. The primary endpoint was the proportion of grade 2-4 neuropsychiatric adverse events (NP-AEs) at week 24. Secondary endpoi…

Rank92.0

Randomized controlled trial

Proof-of-concept randomised controlled trial of data-driven hearing rehabilitation versus standard care in older adults with hearing loss: the healthy hearing for healthy ageing protocol.

BMJ open · 2026 · PMID 42481198

INTRODUCTION: Hearing aids (HAs) can alleviate hearing loss; however, HA rehabilitation is frequently hampered by delayed diagnosis, suboptimal fitting and lack of systematic follow-up. Although the association between hearing loss and cognitive decline has been identified, evidence from randomised controlled trials remains limited. Addressing these gaps is essential for reducing hearing loss-related experiences and evaluating whether effective HA use could reduce the risk of cognitive decline. METHODS AND ANALYSIS…

Rank89.9

Randomized clinical study

Multidimensional associations of HbA1c with behavioural, psychosocial, and economic factors across Educational Pharmaceutical Care Interventional Program (EPCIP) timeline: a prospective, longitudinal, RCT study.

BMC endocrine disorders · 2026 · PMID 42432611

INTRODUCTION: According to real-time data from Gujarat, which has the third highest score in the country nationally (7.55%), shows that behavioral, psychological, and economic stressors are associated with elevating HbA1c levels. The current investigation of multifaceted connection within the educational pharmaceutical care interventional program (EPCIP) timeline provides important information about regional causes of inadequate glycaemic control and aids in the development of tailored diabetes management strategie…

Rank89.4

Randomized clinical study

A Stepped Care, Peer-Delivered Intervention to Improve Substance Use and HIV Medication Adherence in Primary Care in South Africa (Project Khanya): Protocol for a Hybrid Type 2 Effectiveness-Implementation Randomized Controlled Trial.

JMIR research protocols · 2026 · PMID 42390468

BACKGROUND: A substance use disorder (SUD) treatment gap exists globally, with the greatest gaps in settings with the fewest resources. Integrating SUD care into primary care is needed to expand access to SUD care and support adherence to chronic disease services, especially HIV, in high-burden areas. Guided by stakeholder feedback, our team has previously adapted and piloted a peer-delivered behavioral intervention for antiretroviral therapy (ART) adherence for people with HIV and SUD in HIV care ("Khanya")-based …

Rank88.5

Randomized clinical study

Effects of crutch-assisted walking on pain, gait, and hip function in early and middle-stage osteonecrosis: a randomized trial.

Journal of orthopaedic translation · 2026 · PMID 42375815

BACKGROUND: Early-to middle-stage osteonecrosis of the femoral head (ONFH) is commonly associated with pain, gait impairment, and functional limitation. Although protective weight-bearing is frequently recommended, high-quality evidence supporting standardized crutch use as a non-surgical intervention remains limited. OBJECTIVE: To evaluate the effects of daily crutch-assisted walking on pain, hip function, gait performance, health-related quality of life, and bone metabolic markers in patients with early-to middle…

Rank85.0

Randomized clinical study

Nine Months of Fluoxetine Aids in the Reduction of Posttraumatic Stress Symptoms following a Traumatic Musculoskeletal Injury: A Randomized Controlled Trial.

Journal of orthopaedic trauma · 2026 · PMID 42441660

OBJECTIVES: To determine whether Fluoxetine, prescribed by orthopaedic providers during the immediate post-traumatic period, can lessen post-traumatic stress symptoms in survivors of traumatic musculoskeletal injuries. METHODS: Design: Non-Blinded Prospective Randomized Clinical Trial. SETTING: Single Academic Level 1 Trauma Center. PATIENT SELECTION CRITERIA: From July 2021 to December 2023, orthopaedic surgical patients admitted for a high-energy musculoskeletal trauma (injuries not resulting from a ground level …

Rank85.0

Randomized clinical study

Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH): a clinical trial protocol.

BMJ open · 2026 · PMID 42419889

BACKGROUND: The Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH) study is a randomised controlled trial with the overall goal of examining the combined effect of exercise and the growth hormone-releasing hormone analogue tesamorelin on physical function. METHODS: TRIUMPH is a two-site, double-blind, randomised trial of 100 sedentary older adults (aged 50-80 years) living with HIV who are frail or at risk for frailty and have excess abdominal adiposity. Enrolled participants wil…

Rank77.6

Multicenter clinical study

Using agile development methodology to develop a decision aid for complex rectal cancer.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026 · PMID 42173033

INTRODUCTION: Approximately 5-10% of rectal cancer diagnoses are locally advanced (LARC) at presentation and between 4 and 8% recur locally after initial treatment, locally recurrent rectal cancer (LRRC). For patients diagnosed with LARC/LRRC pelvic exenteration (PE) may be potentially curative, but is likely to impact on subsequent quality of life (QoL). To make optimal decisions about their treatment options patients need high quality detailed comprehensible information. To date there are no validated patient dec…

Rank73.8

Multicenter clinical study

Assessment of smoking status and management of smoking cessation in moderate to severe Graves' orbitopathy. A retrospective study of 78 patients.

Annales d'endocrinologie · 2026 · PMID 42167443

INTRODUCTION: Graves' orbitopathy (GO) is a frequent extra-thyroidal manifestation of autoimmune dysthyroidism. Moderate-to-severe forms impair quality of life and visual prognosis. Smoking has been identified for some 30 years as one of the main risk factors. Recently, effective targeted therapies have emerged for GO, but are costly. The aim of this study was to evaluate the assessment of smoking status and management of smoking cessation in a population of moderate-to-severe Graves' orbitopathy in real life. METH…

Rank73.0

Multicenter clinical study

Patient-reported quality of life in people living with HIV in Romania: a cross-sectional PROM-based study.

HIV research & clinical practice · 2026 · PMID 42169383

BACKGROUND: In Romania, people living with HIV represent heterogeneous cohorts shaped by distinct epidemiological and social contexts. While antiretroviral therapy (ART) has markedly improved survival, quality-of-life (QoL) encompasses broader dimensions not fully captured by clinical indicators. Patient-reported outcome measures (PROMs) offer a valuable approach to understanding these dimensions in routine care. METHODS: We conducted a multicenter, cross-sectional study using the OCTAVE PROM to assess patient-repo…

Rank73.0

Multicenter clinical study

Oral Lesions in People Living with HIV: The Lining HIV Study.

Pathogens (Basel, Switzerland) · 2026 · PMID 42515006

Rank51.2

Other PubMed-indexed publication

Comparative exploration of EQ-5D-5L bolt-on variants for fatigue, sleep, and vision in a general population sample.

Health and quality of life outcomes · 2026 · PMID 42387500

OBJECTIVE: Fatigue, sleep, and vision are among the most commonly used EQ-5D-5 L bolt-ons, with multiple alternative wordings. This study aimed to evaluate and compare the psychometric performance of the following bolt-on variants: (1) fatigue (FA) vs. tiredness (TI); (2) vision (VI) vs. VI with reference to vision aids (VI-A); and (3) sleep (SL) vs. sleep with examples in the dimension title (SL-E). METHODS: A representative sample of 1,262 adults in Hong Kong completed an online survey including the EQ-5D-5 L and…

Journal of the International AIDS Society · 2025 · PMID 40462491

Rank98.4

Randomized controlled trial

HIV Care Retention and Cost Analysis in Multi-Month ART Dispensing: A Randomized Controlled Trial in China.

Journal of the International AIDS Society · 2026 · PMID 42339560

INTRODUCTION: Multi-month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV. This study aimed to evaluate the impact of 6-month MMD of antiretroviral therapy (ART) on retention and conduct a cost analysis in China. METHODS: We conducted a randomized, non-blind, non-inferiority study from December 2022 to March 2023 at The First Hospital of China Medical University. Eligible participants …

Rank98.3

Randomized controlled trial

A 3-month clofazimine-rifapentine-containing regimen for drug-susceptible tuberculosis versus standard of care (Clo-Fast): a randomised, open-label, phase 2c clinical trial.

The Lancet. Infectious diseases · 2026 · PMID 40915311

Rank95.7

Randomized controlled trial

Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial.

The lancet. HIV · 2026 · PMID 42202839

BACKGROUND: HIV-specific broadly neutralising antibodies (bNAbs) can maintain viral control after interrupting antiretroviral therapy (ART). We investigated the duration and efficacy of Fc-engineered long-acting bNAbs (LS-bNAbs) in maintaining ART-free HIV control compared with placebo. METHODS: RIO is a double-blind, randomised, placebo-controlled trial. Eligibile participants were adults age 18-60 years, initiated on ART in early-stage HIV infection, virally suppressed on ART, and had no evidence of viral insensi…

Rank95.2

Randomized controlled trial

Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.

International journal of antimicrobial agents · 2026 · PMID 42055353

Rank95.0

Randomized controlled trial

Adenovirus type 5 vector-based COVID-19 vaccine does not increase the likelihood of HIV infection.

Vaccine · 2026 · PMID 41785679

BACKGROUND: There is a concern about the potential increased risk of acquiring HIV infection after vaccination with adenovirus type 5 (Ad5) vector-based vaccines. We aimed to investigate whether Ad5-nCoV increases the risk of HIV infection. METHODS: Between September 2020 and March 2021, a Phase 3 clinical trial was executed to evaluate the efficacy of Ad5-nCoV. This trial, employing a double-blind, randomized, and placebo-controlled design, enrolled 44,247 participants from 66 clinical sites spanning Argentina, Ch…

Rank101.2

Randomized controlled trial

A Randomized Trial to Compare Dolutegravir Plus Boosted Darunavir Versus Recommended Standard of Care Antiretroviral Regimens in People With HIV-1, Whose First-line Non-nucleoside Reverse Transcriptase Inhibitor Therapy Has Failed: Final 96-week Results of the D2EFT Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 40577173

BACKGROUND: Longer-term outcome data following second-line antiretroviral therapy initiation in resource-limited settings is limited, especially in regions where genotypic resistance is inaccessible. This analysis evaluated extended efficacy and tolerability data from the D2EFT study. METHODS: D2EFT is a completed, multicenter, phase IIIB/IV, randomized, open-label trial in 14 low- and middle-income countries. People with human immunodeficiency virus (HIV) who had failed first-line non-nucleoside reverse transcript…

Rank100.7

Randomized controlled trialResult signal: null

Comparison of the Hearing Benefits and User Satisfaction With Hearing Aids and Personal Sound Amplification Products: A Multicenter Prospective Randomized Crossover Trial.

Journal of Korean medical science · 2026 · PMID 42011002

BACKGROUND: While hearing aids (HAs) remain the primary intervention for hearing loss, their high cost creates barriers to access. Personal sound amplification products (PSAPs) are a more affordable alternative, but few studies have compared their efficacy to those of HAs. This multicenter, prospective, randomized, crossover trial was conducted to compare audiologic performance and user satisfaction between HAs and PSAPs to evaluate PSAP potential as alternatives for hearing rehabilitation. METHODS: A total of 73 p…

Rank100.6

Randomized controlled trialResult signal: benefit

Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial.

Trials · 2026 · PMID 41877274

BACKGROUND: Despite the expansion of antiretroviral treatment programmes, the incidence and mortality of HIV-associated cryptococcal meningitis remain high in Africa. Cryptococcal antigen (CrAg) in the blood precedes meningitis. CrAg screening of individuals with advanced HIV disease, combined with pre-emptive fluconazole treatment, reduces the risk of cryptococcal meningitis and associated mortality. However, mortality among individuals with antigenaemia treated with fluconazole is higher than that of CD4-matched …

Rank100.5

Randomized controlled trial

LC16m8 for Pre-exposure Prophylaxis Against Mpox in a High-Risk Population: An Open-Label Randomized Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 39982831

AIDS (London, England) · 2026 · PMID 41467698

OBJECTIVES: We examined whether effects of an agricultural livelihood intervention on food insecurity and psychosocial outcomes remained robust in pregnant compared to nonpregnant women living with HIV, and whether potentially negative associations between pregnancy and these outcomes were alleviated by the intervention. DESIGN: Secondary analysis of the Shamba Maisha cluster-randomized controlled trial ( N = 396 women; NCT02815579). The intervention included agribusiness training and supplies. METHODS: Food insecu…

Rank97.2

Randomized controlled trialResult signal: null

Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

Age and ageing · 2026 · PMID 42407092

Rank97.1

Randomized controlled trial

The Factorial Structure, Reliability, and Validity of a Coping Measure Among Women with HIV and Sexual Trauma in Cape Town, South Africa.

AIDS and behavior · 2026 · PMID 40983787

The dual epidemics of HIV and sexual violence against women complicate HIV care engagement in South Africa. In settings with limited mental health treatment, robust measures to enhance screening and intervention for mental health specific to people with HIV are needed. The current study developed a 42-item assessment for coping with HIV and trauma in isiXhosa. In a randomized controlled trial, 350 participants completed measures of coping, anxiety, traumatic stress, and depression at their baseline assessments. Par…

Rank96.9

Randomized controlled trial

Mediation Effects of Biobehavioral Factors in a Trial of Pharmacotherapy and Intensive Cessation Counseling for People with HIV Who Smoke Cigarettes in Nairobi, Kenya.

AIDS and behavior · 2026 · PMID 41369963

There is growing recognition of the important health risks of tobacco use in people with HIV (PWH). Multiple randomized controlled trials have tested cessation treatments in this population, but little is known about factors that mediate successful quitting. We conducted a randomized, placebo-controlled 2 × 2 factorial design trial of a behavioral intervention (Positively Smoke Free [PSF] one-on-one counseling) vs. brief advice to quit ± bupropion vs. placebo in PWH who smoked cigarettes in Nairobi, Kenya. Abstinen…

Rank96.6

Randomized controlled trialResult signal: null

The Effect of an Educational Intervention Based on the Theory of Planned Behavior on Preventing Drug Relapse Among Men with Substance Use Disorder.

Substance use & misuse · 2026 · PMID 41020737

BACKGROUND: Drug abuse has severe physical and psychological consequences, contributing to family and social instability. Given the challenges of substance use disorders, prevention is crucial. This study aimed to evaluate the effect of an educational intervention based on the Theory of Planned Behavior (TPB) on preventing drug relapse among those with substance use disorder in treatment centers in Shiraz. METHODS: This experimental study included 200 drug-dependent individuals undergoing methadone and buprenorphin…

Rank96.6

Randomized controlled trial

An integrated HIV and chronic disease intervention to reduce HIV infection risk among older men who have sex with men in China: a randomized controlled trial.

BMC public health · 2026 · PMID 42021278

INTRODUCTION: Population ageing has altered the health profile of men who have sex with men (MSM) in China, with older MSM experiencing overlapping challenges related to sexual health risks, chronic diseases, and stigma-related barriers to care. Conventional HIV interventions often fail to address these age-specific health priorities. This study evaluated an integrated HIV and chronic disease intervention, informed by the Health Belief Model (HBM), to examine its impact on HIV infection risk among older MSM. METHOD…

Rank96.6

Randomized controlled trial

Adapted Motivational Interviewing Reduces Substance Use and Sexual Risk Taking Among Partnered Sexual Minority Men Aged 18-35 Years: Results of the PARTNER Study.

Journal of acquired immune deficiency syndromes (1999) · 2026 · PMID 41343494

BACKGROUND: The development of interventions addressing drug use and sexual HIV infection risk for emerging adult sexual minority men in primary relationships is a public health priority. This study evaluated the efficacy of PARTNER, a 4-session motivational interviewing intervention, to reduce cannabis and illicit drug use, increase preexposure prophylaxis (PrEP) uptake, and reduce HIV infection risk. SETTING: Staff at Hunter College in New York City, NY, administered study procedures between January 2018 and Febr…

Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.