Viral infections evidence library
Human Papillomavirus Infection
A living PubMed evidence library for HPV prevention, vaccination, persistent infection, precancer treatment, recurrence, and therapeutic research.
PubMed only
Research ranked
Conflicts shown
Data downloadable
Living evidence synopsis
What the current PubMed collection shows.
Alexandria currently organizes 654 non-retracted PubMed-indexed records for Human Papillomavirus Infection. The structured collection includes 14 guideline or consensus records, 101 evidence syntheses/systematic reviews/meta-analyses, and 91 randomized or phase III studies. 135 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 525 of 654 included records.
Evidence data
Research landscape
Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.
Publication activity
Latest 12 represented yearsRecords by publication year
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2024
67
2025
540
2026
Evidence composition
Study designs
Transparency
Conflict-of-interest reporting
Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.
Abstract result signals
Extracted result direction
Reported outcomes
Numerical results extracted from PubMed abstracts
Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.
Non-pooled ratio measures
Reference = 1.0
Hazard, risk, and odds ratios reported in abstracts
0.250.51.02.04.0
View extracted numerical results 60
| Publication | Outcome | Measure | Reported value | Source |
|---|---|---|---|---|
| Adjuvant VaccInation After Conization for the Treatment for CervicAL Dysplasia.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026 | not_reported | Hazard Ratio | 0.9 95% CI 0.47–1.73 | PMID 40277212 |
| FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 | progression-free survival | Hazard Ratio | 1.052 P = 0.023 | PMID 41385605 |
| FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 | progression-free survival | Hazard Ratio | 1.038 P = 0.023 | PMID 41385605 |
| Phase 2 Prospective Trial of Personalized Radiation Therapy Fractionation in Human Papillomavirus Positive Oropharyngeal Cancer.International journal of radiation oncology, biology, physics · 2026 | not_reported | Odds Ratio | 60.0 | PMID 41519405 |
| Human Papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan - 2023.Human vaccines & immunotherapeutics · 2026 | not_reported | Odds Ratio | 1.52 95% CI 1.06–2.18 | PMID 41623232 |
| Human Papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan - 2023.Human vaccines & immunotherapeutics · 2026 | not_reported | Odds Ratio | 1.47 95% CI 1.03–2.07 | PMID 41623232 |
| Human Papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan - 2023.Human vaccines & immunotherapeutics · 2026 | not_reported | Odds Ratio | 1.63 95% CI 1.14–2.32 | PMID 41623232 |
| Human Papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan - 2023.Human vaccines & immunotherapeutics · 2026 | not_reported | Odds Ratio | 1.65 95% CI 1.12–2.47 | PMID 41623232 |
| Human Papillomavirus vaccine knowledge and recommendation practice among primary care providers, Almaty, Kazakhstan - 2023.Human vaccines & immunotherapeutics · 2026 | not_reported | Odds Ratio | 3.07 95% CI 2.11–4.54 | PMID 41623232 |
| Phase I/II clinical study of next-generation photodynamic therapy (L-PDT) using talaporfin sodium (Laserphyrin®) for cervical intraepithelial neoplasia: Efficacy, safety, and fertility preservation.Photodiagnosis and photodynamic therapy · 2026 | not_reported | Odds Ratio | 100.0 | PMID 41638379 |
| Impact of male genital tract infections on semen quality: a systematic review and meta-analysis.Fertility and sterility · 2026 | not_reported | Odds Ratio | 10.63 | PMID 41825760 |
| Impact of male genital tract infections on semen quality: a systematic review and meta-analysis.Fertility and sterility · 2026 | not_reported | Odds Ratio | 1.43 | PMID 41825760 |
| Beyond dietary habits: ultra-processed food consumption reveals the association with HPV infection in U.S. women.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2026 | not_reported | Odds Ratio | 1.18 95% CI 1.07–1.32 | PMID 42059104 |
| Beyond dietary habits: ultra-processed food consumption reveals the association with HPV infection in U.S. women.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2026 | not_reported | Odds Ratio | 1.26 95% CI 1.04–1.53 | PMID 42059104 |
| Immunogenicity of 2 versus 3 dose HPV vaccination by HIV infection status in Eswatini.Vaccine · 2026 | not_reported | Odds Ratio | 7.0 | PMID 42142523 |
| Aristolochic acid and the risk of female lung cancer: Population-based case-control study in Taiwan.Cancer epidemiology · 2026 | not_reported | Odds Ratio | 1.08 95% CI 1.04–1.12 | PMID 42217389 |
| Serum human papilloma virus detection following treatment of cervical cancer: prevalence and its correlation with recurrence.Cancer causes & control : CCC · 2026 | recurrence | Odds Ratio | 29.17 95% CI 7.32–116.24 | PMID 42347892 |
| Cost-Effectiveness of an HPV Vaccination Program in the Postpartum Period.Journal of women's health (2002) · 2026 | CIN2+ | Odds Ratio | 3.0 | PMID 42411364 |
| Long-term predictors of recurrence in pediatric recurrent respiratory papillomatosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 | recurrence | Hazard Ratio | 0.62 | PMID 42472951 |
| Long-term predictors of recurrence in pediatric recurrent respiratory papillomatosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 | recurrence | Hazard Ratio | 0.66 | PMID 42472951 |
| Long-term predictors of recurrence in pediatric recurrent respiratory papillomatosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 | recurrence | Hazard Ratio | 0.53 | PMID 42472951 |
| Efficacy and Safety of Ionic Contra-viral Therapy (Digoxin-furosemide) in the Treatment of Multiple Cutaneous Warts: A Systematic Review, Meta-analysis, and Trial Sequential Analysis.Current drug research reviews · 2026 | not_reported | Risk Ratio | 13.27 95% CI 2.93–60.17 p = 0.0018 | PMID 40873359 |
| Efficacy and Safety of Ionic Contra-viral Therapy (Digoxin-furosemide) in the Treatment of Multiple Cutaneous Warts: A Systematic Review, Meta-analysis, and Trial Sequential Analysis.Current drug research reviews · 2026 | not_reported | Risk Ratio | 0.66 95% CI 0.09–5.09 p = 0.69 | PMID 40873359 |
| Efficacy and Safety of Ionic Contra-viral Therapy (Digoxin-furosemide) in the Treatment of Multiple Cutaneous Warts: A Systematic Review, Meta-analysis, and Trial Sequential Analysis.Current drug research reviews · 2026 | not_reported | Risk Ratio | 1.33 95% CI 0.47–3.79 p = 0.59 | PMID 40873359 |
| Efficacy and Safety of Ionic Contra-viral Therapy (Digoxin-furosemide) in the Treatment of Multiple Cutaneous Warts: A Systematic Review, Meta-analysis, and Trial Sequential Analysis.Current drug research reviews · 2026 | not_reported | Risk Ratio | 1.45 95% CI 0.29–7.22 p = 0.65 | PMID 40873359 |
| Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.Medicine · 2026 | not_reported | Risk Ratio | 1.698 P = .015 | PMID 42363527 |
| Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.Medicine · 2026 | not_reported | Risk Ratio | 1.488 P = .015 | PMID 42363527 |
| Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.Medicine · 2026 | not_reported | Risk Ratio | 1.679 P = .015 | PMID 42363527 |
| Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.Medicine · 2026 | not_reported | Risk Ratio | 1.783 P = .015 | PMID 42363527 |
| Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.Medicine · 2026 | not_reported | Risk Ratio | 1.819 P = .015 | PMID 42363527 |
| Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.Medicine · 2026 | pathological complete response | Risk Ratio | 2.15 P = .01 | PMID 42363527 |
| Local carboxymethyl-β-glucan and polycarbophil therapy is associated with regression of low-grade cervical cytological abnormalities: a prospective observational study.Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina · 2026 | not_reported | Risk Ratio | 0.22 95% CI 0.08–0.6 p < 0.001 | PMID 42592979 |
| REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective study.World journal of surgical oncology · 2026 | not_reported | Odds Ratio | 0.34 95% CI 0.14–0.81 | PMID 42035080 |
| REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective study.World journal of surgical oncology · 2026 | not_reported | Odds Ratio | 0.36 95% CI 0.17–0.76 | PMID 42035080 |
| REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective study.World journal of surgical oncology · 2026 | not_reported | Odds Ratio | 0.26 95% CI 0.12–0.58 | PMID 42035080 |
| Health Outcome Determinants of Human Papillomavirus Vaccination in Adult Women in Spain.Vaccines · 2026 | not_reported | Odds Ratio | 2.16 p < 0.001 | PMID 42188830 |
| Health Outcome Determinants of Human Papillomavirus Vaccination in Adult Women in Spain.Vaccines · 2026 | not_reported | Odds Ratio | 0.63 p < 0.001 | PMID 42188830 |
| Health Outcome Determinants of Human Papillomavirus Vaccination in Adult Women in Spain.Vaccines · 2026 | not_reported | Odds Ratio | 0.92 p < 0.001 | PMID 42188830 |
| Health Outcome Determinants of Human Papillomavirus Vaccination in Adult Women in Spain.Vaccines · 2026 | not_reported | Odds Ratio | 7.48 p < 0.001 | PMID 42188830 |
| Health Outcome Determinants of Human Papillomavirus Vaccination in Adult Women in Spain.Vaccines · 2026 | not_reported | Odds Ratio | 1.49 p < 0.001 | PMID 42188830 |
Research transparency
Funding and conflicts of interest
Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.
NCI NIH HHS109
National Natural Science Foundation of China18
NIDCR NIH HHS18
NIH HHS18
NIAID NIH HHS15
National Institutes of Health (NIH)9
U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR)9
Cancer Research UK7
View records with declared financial or industry relationships 12
A Tale of Two Cohorts: Comparing HPV Vaccination Barriers and Facilitators Among HIV-Negative and HIV-Positive Women in Tennessee.
The authors declare that this study received funding from Merck Sharp & Dohme LLC, Grant # A24-1019-001. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.
PMID 42652293 · 2026Clinical Validation of the Roche cobas and cobas 4800 Human Papillomavirus Tests on Self-Collected Vaginal Dry Swabs versus Practitioner-Collected Cervical Specimens Using the VALHUDES Protocol.
Disclosure Statement M.S., J.M.L.B., D.H., and C.D.W. are investigators on the Compass Trial, for which the Australian Centre for the Prevention of Cervical Cancer (ACPCC) has received funding from Roche Molecular Systems. ACPCC, the employer of M.S., A.L., and D.H., has received funding, instruments, and consumables from Roche for other clinical validation studies. C.D.W. and A.S. are members of the Board of ACPCC. J.M.L.B., M.S., and D.H. are investigators on a Global Alliance for Chronic Diseases/National Health and Medical Research Council–funded study in India [Self-Collected HPV Evaluation for the Prevention of Cervical Cancer (SHE-CAN)], which has received donated tests and swabs from Copan, Abbott, and Seegene. Sciensano, the employer of M.A., received funding in the framework of VALidation of HPV GENotyping Tests (VALGENT) and Validation of Human Papillomavirus Assays and Collection Devices for Self-Samples and Urine Samples, which are researcher-induced fora for evaluation of human papillomavirus tests on cervical and vaginal samples, respectively. M.A. did not receive any financial or material benefit from these projects. Sciensano also received support from the European Society of Gynecological Oncology, German Guideline Program in Oncology (German Cancer Aid project), World Health Organization (Geneva, Switzerland; via Agreement for Performance of Work for Guidelines on Screening and Treatment of Pre-Invasive Cervical Disease), and the European Commission Initiative on Cervical Cancer. M.A. has received support from the European Joint Action EUCanScreen grant 101162959, funded by the EU4Health Programme of the European Commission; and the European Commission Initiative on Cervical Cancer, coordinated by the International Agency for Research on Cancer and the Joint Research Center.
PMID 42320756 · 2026Amivantamab in Recurrent/Metastatic Head and Neck Squamous Cell Cancer After Checkpoint Inhibitor and Chemotherapy: Pivotal Results From the Phase Ib/II OrigAMI-4 Study.
Disclosures provided by the authors are available with this article at DOI https://doi.org/10.1200/JCO-26-01042. The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center. Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments). Barbara Burtness . Consulting or Advisory Role: Merck, ALX Oncology, IO Biotech, Genentech/Roche, Merck KGaA, Coherus Biosciences, Rakuten Medical, Mirati Therapeutics, Merus, Janssen Oncology, Takeda, GlaxoSmithKline, AstraZeneca, Induxion, Astellas Pharma. Research Funding: Merck (Inst), CUE Biopharma (Inst), Merck, IO Biotech (Inst). Patents, Royalties, Other Intellectual Property: Royalties from Up-to-Date chapter. Expert Testimony: Cel-Sci Corporation. Travel, Accommodations, Expenses: Merck. Ari J. Rosenberg . Stock and Other Ownership Interests: Privo Technologies. Consulting or Advisory Role: Nanobiotix, EMD Serono, Vaccitech, Novartis, Eisai, Astellas Pharma, Regeneron, RAPT Therapeutics, Geovax Labs, Janssen, Summit Therapeutics. Speakers' Bureau: Coherus Biosciences. Research Funding: Hookipa Biotech (Inst), EMD Serono (Inst), Purple Biotech (Inst), Bristol Myers Squibb/Celgene (Inst), BeiGene (Inst), AbbVie (Inst), Astellas Pharma (Inst), Pfizer (Inst), Janux Therapeutics (Inst). Benoit Calderon . Speakers' Bureau: Merck Serono. Shigenori Kadowaki . Honoraria: Bayer, Bristol Myers Squibb, Chugai Pharma, Ono Pharmaceutical, Merck KGaA, Daiichi Sankyo, Eisai, MSD, Taiho Pharmaceutical, Novartis, Astellas Pharma. Research Funding: Ono Pharmaceutical (Inst), Lilly (Inst), MSD (Inst), Chugai Pharma (Inst), Daiichi Sankyo (Inst), Bayer (Inst), AstraZeneca (Inst), AbbVie (Inst), Astellas Pharma (Inst), Novartis (Inst), Janssen (Inst). Paul L. Swiecicki . Employment: University of Michigan. Honoraria: Janssen Research & Development. Research Funding: Ascentage Pharma Group (Inst), Summit Therapeutics (Inst), Regeneron (Inst), Astellas Pharma (Inst), Kineta (Inst), Volastra Therapeutics (Inst), LigaChem Biosciences (Inst), Remix Therapeutics (Inst), Janssen Oncology (Inst), Rgenta (Inst), Coherus Biosciences (Inst). Patents, Royalties, Other Intellectual Property: Co-inventor of a patent pending related to HPV ctDNA assay technology. Jessica L. Geiger . Consulting or Advisory Role: Janssen Oncology, Regeneron, Coherus Biosciences, Replimune, Johnson & Johnson/Janssen, Eisai. Research Funding: Janssen Oncology (Inst), Merus (Inst), Astellas Pharma (Inst). William Ince . Consulting or Advisory Role: J&J, Regeneron, MSD Oncology, AstraZeneca. Speakers' Bureau: Regeneron, Merck Serono, MSD Oncology, AstraZeneca, Astellas Pharma, Johnson & Johnson/Janssen, Ipsen. Travel, Accommodations, Expenses: Ipsen, Recordati, Genesis Cancer Care. Dennis Hahn . Consulting or Advisory Role: Merck, MSD, BMSi, BeOne. Travel, Accommodations, Expenses: Merck Serono. Ye Guo . Honoraria: Merck Serono, Roche, MSD, BeOne. Consulting or Advisory Role: MSD, AstraZeneca, BMS, Johnson & Johnson. Douglas Adkins . Consulting or Advisory Role: Merck, CUE Biopharma, Immunitas, Kura Oncology, Boehringer Ingelheim, Genmab/Seattle Genetics, Adlai Nortye, InhibRx, Merus, Purple Biotech, Regeneron, Adcendo, AstraZeneca, GlaxoSmithKline, Johnson & Johnson/Janssen, Pyxis, Tubulis GmbH. Research Funding: Pfizer (Inst), Lilly (Inst), Merck (Inst), Celgene (Inst), Novartis (Inst), AstraZeneca (Inst), Blueprint Medicines (Inst), Bristol Myers Squibb (Inst), Kura Oncology (Inst), CUE Biopharma (Inst), Cofactor Genomics (Inst), Debiopharm Group (Inst), ISA Pharmaceuticals (Inst), Gilead Sciences (Inst), BeiGene (Inst), Roche (Inst), Vaccinex (Inst), Immutep (Inst), Hookipa Biotech (Inst), Epizyme (Inst), Adlai Nortye (Inst), BioAtla (Inst), Boehringer Ingelheim (Inst), Calliditas Therapeutics (Inst), Genmab (Inst), NATCO Pharma (Inst), Tizona Therapeutics, Inc (Inst), Seagen (Inst), Merus (Inst), InhibRx (Inst), Erasca, Inc (Inst), Alentis Therapeutics (Inst), Coherus Biosciences (Inst), Takeda (Inst), Xilio Therapeutics (Inst), GlaxoSmithKline (Inst), Johnson & Johnson/Janssen (Inst), Rgenta (Inst), AVEO (Inst), Daiichi Sankyo Europe GmbH (Inst), Exelixis (Inst), Tempus (Inst). Robert Metcalf . Honoraria: Sanofi. Consulting or Advisory Role: Avacta Life Sciences, Rgenta. Myung-Ju Ahn . Honoraria: AstraZeneca, MSD, TAKEDA, Amgen, Merck Serono, YUHAN, Daiichi Sankyo/AstraZeneca, Boehringer Ingelheim. Consulting or Advisory Role: AstraZeneca, MSD, TAKEDA, Amgen, Merck Serono, Pfizer, YUHAN, Daiichi Sankyo/AstraZeneca, Genexine, Voronoi Health Analytics, Boehringer Ingelheim, AIMEDBIO. Ammar Sukari . Stock and Other Ownership Interests: Immunomedics. Honoraria: Merck, AstraZeneca/Daiichi Sankyo. Consulting or Advisory Role: Merck, Eisai. Speakers' Bureau: Coherus Biosciences, MSD. Irene Braña . Consulting or Advisory Role: Merck Sharp & Dohme, Cancer Expert Now, Merus, Gilead Sciences, Bicara Therapeutics, AstraZeneca, Boehringer Ingelheim Spain, Pyxis, Pyxis. Speakers' Bureau: Bristol Myers Squibb, Merck Serono, MSD. Research Funding: AstraZeneca (Inst), Bristol Myers Squibb (Inst), Celgene (Inst), GlaxoSmithKline (Inst), Janssen Oncology (Inst), Kura Oncology (Inst), Merck Sharp & Dohme (Inst), Novartis (Inst), Pfizer (Inst), Roche (Inst), Shattuck Labs (Inst), Nanobiotix (Inst), Seagen (Inst), Immutep (Inst), Debiopharm Group (Inst), Regeneron (Inst), Boehringer Ingelheim (Inst), ISA Pharmaceuticals (Inst), Merck Serono (Inst), VCN Biosciences (Inst), Tolremo (Inst), Merus (Inst), Tango Therapeutics (Inst), IDEAYA Biosciences (Inst), Gilead Sciences (Inst), Bicara Therapeutics (Inst), AOP Health (Inst), PharmaMar (Inst), Hookipa Pharma (Inst), Epizyme (Inst), Dragonfly Therapeutics (Inst), SERVIER (Inst), Pyxis (Inst). Bhumsuk Keam . Honoraria: MSD Oncology. Consulting or Advisory Role: Handok, Trial Informatics, TiumBio, Yuhan, Bicara Therapeutics, AVEO. Research Funding: AstraZeneca, Bayer. Hideki Tanaka . Honoraria: MSD K.K. Merck & Co., Inc, Ono Pharmaceutical, Chugai Pharma, Janssen. Patents, Royalties, Other Intellectual Property: National Cancer Center East Fractionated Light Irradiation in Photoimmunotherapy (Inst). Siddharth Sheth . Honoraria: Eisai, InhibRx, Coherus Biosciences. Speakers' Bureau: Exelixis. Research Funding: AstraZeneca (Inst), Inovio Pharmaceuticals (Inst), Exelixis (Inst), Regeneron (Inst), Merck (Inst). Travel, Accommodations, Expenses: Merus. Marc Oliva . Honoraria: MSD Oncology, Merck, Agilent. Consulting or Advisory Role: Merck KGaA, MSD Oncology, Obatica, Pyxis, Transgene, Bicara Therapeutics, Ipsen. Research Funding: Merck, Roche (Inst), ALX Oncology (Inst), GlaxoSmithKline (Inst), MSD Oncology (Inst), ISA Pharmaceuticals (Inst), Boehringer Ingelheim (Inst), Seagen (Inst), Seagen (Inst), BeiGene (Inst), Pfizer (Inst). Travel, Accommodations, Expenses: MSD Oncology, Bristol Myers Squibb/Pfizer, Merck, BeiGene, Boehringer Ingelheim. Xuesong Lyu . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Joshua C. Curtin . Employment: Janssen Research & Development. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Kiichiro Toyoizumi . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. John Xie . Employment: JNJ. Stock and Other Ownership Interests: JNJ. Mark Wade . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Research Funding: Johnson & Johnson/Janssen. Travel, Accommodations, Expenses: Johnson & Johnson/Janssen. Other Relationship: Johnson & Johnson/Janssen. Brooke Diorio . Employment: Janssen Research & Development. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Travel, Accommodations, Expenses: Janssen Research & Development. Aastha Kapoor . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Travel, Accommodations, Expenses: Johnson & Johnson/Janssen. Emrullah Yilmaz . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Mahadi Baig . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Priya Kim . Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Remy B. Verheijen . Employment: Johnson & Johnson. Stock and Other Ownership Interests: Johnson & Johnson. Sujay Shah . Employment: Johnson & Johnson/Janssen. Stock and Other Ownership Interests: Johnson & Johnson/Janssen. Kevin J. Harrington . Honoraria: AstraZeneca (Inst), Boehringer Ingelheim (Inst), Merck Serono (Inst), MSD (Inst), Replimune (Inst), Johnson & Johnson (Inst), Nanobiotix (Inst), ALX Oncology (Inst), BeiGene (Inst), GlaxoSmithKline (Inst), Bicara Therapeutics (Inst), Merus (Inst), PDS Biotechnology (Inst), Exelixis (Inst), Flamingo Pharma (Inst), PsiVac Ltd (Inst), AbbVie (Inst), QBiotics (Inst). Consulting or Advisory Role: AstraZeneca (Inst), Boehringer Ingelheim (Inst), Merck Serono (Inst), MSD (Inst), Replimune (Inst), Nanobiotix (Inst), Onchilles Pharma (Inst). Research Funding: AstraZeneca (Inst), Replimune (Inst), Boehringer Ingelheim (Inst). No other potential conflicts of interest were reported.
PMID 42218660 · 2026Linking clinical trial data with real-world data for enhanced clinical evidence generation: methodological considerations and recommendations.
A-KM is an employee of Bayer AG and holds stock options in the company. CP and JD-D were employees of ModernaTX, Inc. and held stock options in the company at the time this manuscript was conceptualized. KG is a full-time employee of Datavant. TS is an employee of ModernaTX, Inc. and holds stock options in the company. JBS reports research grants from the National Heart, Lung, and Blood Institute (1R01HL169517, 1R01HL173998), Anumana, Ultromics, Philips Healthcare, EVERSANA Lifesciences, and Bracco Diagnostics; consulting for Bracco Diagnostics, Edwards Lifesciences, Philips Healthcare, General Electric Healthcare, and EVERSANA; membership on the scientific advisory boards for Ultromics, HeartSciences, and EchoIQ; and membership on the data safety monitoring board for Pfizer. MS is a former employee of Bayer AG and GSK and holds Bayer and GSK shares. HL is an employee of Neurocrine Biosciences and may hold stock options/shares in the company. DT is an employee of AZ-Alexion and holds shares of AstraZeneca; the views presented are their own and do not represent those of AstraZeneca-Alexion. MN was employed by Medidata Solutions during the conduct of this study and is now employed by UCB, Inc. PV is a full-time employee of Bayer AG and owns stock in Bayer, Merck, Novo Nordisk, J&J, Eli Lilly, Abbott, BMS, and Pfizer. MB is an employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and owns stock in Merck & Co., Inc., Rahway, NJ, USA. The handling editor TJ declared a past co-authorship with the author MS at the time of review.
PMID 42630489 · 2026HuB/HuR inhibition decreases HPV E6 and E7 proteins, stabilizes p53, and induces integrated stress to impair cervical cancer cell growth.
Competing interests statement:N.F. and L.B.N. has patent (US 12,435,091 B2) as part of UAB on SRI-42127.
PMID 42647117 · 2026Preclinical Development of ARV-2001, an Intradermally Administered mRNA-Lipid Nanoparticle Immunotherapeutic for the Treatment of HPV-16-Positive Cervical High-Grade Squamous Intraepithelial Lesions.
Z.H., J.H.J., G.M.G. and R.X. are currently employed by Pinion Immunotherapeutics. H.Z. is former employee of Pinion Immunotherapeutics. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. J.C. is a co-founder of Pinion Immunotherapeutics and serves on its Scientific Advisory Board. The authors report no other conflicts of interest in this work.
PMID 42646731 · 2026High Risk of New HPV Infection Acquisition Among Unvaccinated Young Men.
Potential conflicts of interest. A. R. G. reports receipt of support in the form of medical writing for the current manuscript, grants, and consulting fees from Merck Sharp & Dohme LLC. J. M. P. reports receipt of consulting fees from Merck Sharp & Dohme, LLC, Vir Biotechnologies, Antiva Biosciences, and Roche Diagnostics; has received payment from Merck Sharp & Dohme LLC, for lectures, presentations, speakers’ bureaus, and manuscript writing or educational events; is an honorary board member of the International Papillomavirus Society; and holds stock or stock options in Virion Therapeutics. S. G. has received grants from Inovio and Franz Viral Technologies; consulting fees from THD America; and payment or honoraria from Merck Sharp & Dohme, LLC, for speakers’ bureaus. S. G. and J. E. T. have received support from Merck Sharp & Dohme, LLC, for the present manuscript. A. L., B. D., A. S., C. V., and J. E. T. are employees of Merck Sharp & Dohme, LLC. A. L., B. D., A. S., and J. E. T. hold stock in Merck & Co, Inc, Rahway, NJ, USA. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
PMID 38012959 · 2024ASO Special Article: Proceedings of the Inaugural Joint US-India Cancer Dialogue: Accelerating Collaboration to Advance Cancer Prevention, Early Detection, Treatment, and Care.
Disclosure: Dr. Parikh has held Equity in C2i Genomics, Khora, OneCell, XGenomes, Cadex, and Parithera. In the last 36 months, she has served as an advisor/consultant for Zola, CVS, Phesi, Xilio, 3T Biosciences, Do More Diagnostics, Summit Therapeutics, Pfizer, Regeneron, GSK, Foundation Medicine, Careset, Value Analytics Labs, Naterara, Adroya, Astra Zeneca, Scare, Hookipa, Guardant, Abbvie, Seagen, Mirati, Takeda, PMV, Kahr, Sirtex, Eli Lilly, Merck, Amgen, Delicate, Exact, Caris, BMS, Incyte, Pheon, Neogenomics, J & J, Exact, Boehringer Ingelheim, Novartis, Third Rock Ventures, MPM Capital, and Science For America. She is Chief Scientist of Reversing Early Recurrence. She receives fees from Up to Date. She has received travel fees from Karkinos Healthcare. She has received research funding to the Institution from PMV Pharmaceuticals, BMS, Mirati, Erasca, Genentech, Daiichi Sankyo, Syndax, Revolution Medicine, Lily, Xilio, and Parthenon.
PMID 42166060 · 2026Rapid Systematic Review-Informed Multidisciplinary Expert Consensus on the Management of HPV-Positive Women with Low-Grade Cervical Lesions and the Role of a Coriolus versicolor-Based Vaginal Treatment.
J.C. declares that he has received travel and/or research grants and/or honoraria for conferences and/or consultancy fees from Genómica, GSK, Merck, Procare Health, Qiagen, Roche, and SPMSD; N.N declares that she has received travel and/or research grants and/or honoraria for conferences and/or consultancy fees from Procare Health and MSD, and reports article publishing charges provided by Procare Health and writing assistance provided by GOC Health Consulting; M.R.B. declares that she has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper; R.C. declares that she has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper; J.S. declares that he has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper; A.R.J. reports financial support provided by Procare Health; F.L. reports he has received consulting/advisory fees provided by Procare Health, and speaking and lecture fees provided by Procare Health, Bayer Schering Pharma AG and BTL Medical Technologies s.r.o; L.S. declares that he has received speaking and consultancy fees from Shionogi, Iprad, and Procare Health.
PMID 42512825 · 2026Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative.
Financial Disclosure Alex Vosooney is a board member of the Minnesota Academy of Family Physicians and reports past payment from the American Academy of Family Physicians. Heidi D. Nelson reports ongoing royalties payment from Elsevier and Wolters Kluwer, and payment to her institution by the Agency for Healthcare Research & Quality (AHRQ). Nancy Byatt reports receiving past payment from The Kinitex Group; JBS, International; VentureWell; honorarium from James Bell Associates; payment from Elsevier for serving as an editor; and payment from Reproductive Mental Health Consultants for serving as a consultant. May Lau reports past payment from the American Academy of Pediatrics and past payment from the Coalition to Expand Contraceptive Access. Julie K. Wood reports past payment from the American Academy of Family Physicians and US Against Alzheimers. Linda Humphrey receives royalties from UpToDate. Margot L. Savoy reports payment from Merck for authorship of the immunization chapter for Merck Manual and from Novo Nordisk in the form of travel and honorarium for serving on an obesity advisory panel on behalf of AAFP. Kimberly Gregory reports payment to her institution from the California Dept of Public Health California Healthcare Foundation NCQA. The other authors did not report any potential conflicts of interest. Participation in the Advisory Panel, Multidisciplinary Steering Committee, WPSI or authorship of this document does not constitute organizational or individual endorsement of the recommendations or conclusions. This information or content and conclusions are those of the authors and should not be construed as the official position nor policy of, nor should any endorsements be inferred by HRSA, HHS, or the U.S. Government. All financial and intellectual disclosures of interest were declared, and potential conflicts were discussed and managed following the conflict of interest process of the American College of Obstetricians & Gynecologists ( https://www.womenspreventivehealth.org/wp-content/uploads/Methodology-August-2025.pdf ).
PMID 42024880 · 2026IPVS Consensus Statement on The Natural History of Cervical Human Papillomavirus Infection.
Potential conflicts of interest. A. H. has received reagents from Roche Diagnostics, Denmark, and an honoraria from Exeltis, outside the submitted work. A. F. R. is currently employed by Hologic, although this work was undertaken as part of her faculty appointment at Johns Hopkins School of Public Health; Hologic had no role in writing, reviewing, or funding this work. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
PMID 41239758 · 2026Examining Artificial Intelligence Chatbots' Responses in Providing Human Papillomavirus Vaccine Information for Young Adults: Qualitative Content Analysis.
Conflicts of Interest: MLK has received investigator-initiated research funding from Merck, administered through Purdue University, and has served as a consultant to Merck.
PMID 41707197 · 202601
Current Standard-of-Care Sources
Alexandria uses this label only for PubMed-indexed guidelines or consensus documents. These are source publications, not individualized recommendations.
Screening for Cervical Cancer.
Obstetrics and gynecology · 2026
PMID 42024877International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 report on Terminology, Grading, and Molecular Testing Practices.
The American journal of surgical pathology · 2026
PMID 40826809Clinical practice guideline for high-risk human papillomavirus testing in cervical cancer screening: a consensus statement from the Korean Society of Gynecologic Oncology.
Journal of gynecologic oncology · 2026
PMID 41834415Australian guidelines for anal cancer screening using anal human papillomavirus testing with cytology triage in people living with HIV.
HIV medicine · 2025
PMID 41130598Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative.
Obstetrics and gynecology · 2026
PMID 42024880SEOM-TTCC clinical guidelines for the treatment of head and neck cancer (2025).
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
PMID 41843267Updated clinical practice guidelines for human papillomavirus vaccination: the Korean Society of Gynecologic Oncology recommendations.
Journal of gynecologic oncology · 2026
PMID 41775253Role of radiotherapy in the management of anal canal cancer: Recommendations of the Société française de radiothérapie oncologique.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2025
PMID 41273885[Cervical cancer screening : implementation of the hr-HPV test].
Revue medicale de Liege · 2025
PMID 41229231Radiotherapy for penile cancers: 2025 update.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2025
PMID 41205450Management of women with abnormal cervical cytology: Update of French guidelines after the implementation of HPV screening.
European journal of obstetrics, gynecology, and reproductive biology · 2025
PMID 40957151High-Risk HPV Testing in Head and Neck Carcinoma: Key Updates from the 2025 College of American Pathologists Guideline.
Head and neck pathology · 2025
PMID 4102108202
Highest-Priority Research
Screening for Cervical Cancer.
Obstetrics and gynecology · 2026
This committee statement announces the American College of Obstetricians & Gynecologists' qualified endorsement of the 2026 Women's Preventive Services Initiative's (WPSI) updated cervical cancer screening guidelines and addresses cervical cancer screening for patients at average risk in the following age categories: 21-29 years, 30-65 years, and older than 65 years. This committee statement discusses specific qualifications to the WPSI guidelines, particularly regarding self-collection for primary high-risk human papillomavirus screening, among other implementation considerations.
PMID 42024877International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 report on Terminology, Grading, and Molecular Testing Practices.
The American journal of surgical pathology · 2026
The classification and diagnosis of penile intraepithelial neoplasia (PeIN) remains inconsistent among pathologists, despite its recognized role and understanding as a precursor to penile squamous cell carcinoma (PSCC). The International Society of Urological Pathology (ISUP) convened a consensus group of multidisciplinary thought leaders to assess current global practices regarding the usage of terminology, grading, and molecular testing in penile cancer precursor lesions. A preconference survey was distributed to ISUP members in 2024, collecting responses from 112 pathologists, predominantly genitourinary specialists, to evaluate the use of penile cancer precursor lesion classification sys…
PMID 40826809Clinical practice guideline for high-risk human papillomavirus testing in cervical cancer screening: a consensus statement from the Korean Society of Gynecologic Oncology.
Journal of gynecologic oncology · 2026
High-risk human papillomavirus (hrHPV) is a necessary cause of cervical cancer, and hrHPV testing has increasingly been recognized as an effective screening tool that overcomes the limitations of cytology-based screening. However, standardized clinical guidance for the use of hrHPV testing in cervical cancer screening has been limited in Korea, resulting in variability in clinical practice. This consensus-based clinical practice guideline was developed under the auspices of the Korean Society of Gynecologic Oncology through multidisciplinary collaboration involving experts in gynecology, pathology, laboratory medicine, and public health. Relevant domestic and international evidence was syste…
PMID 41834415Australian guidelines for anal cancer screening using anal human papillomavirus testing with cytology triage in people living with HIV.
HIV medicine · 2025
OBJECTIVES: To develop Australian anal cancer screening guidelines for people living with HIV. METHODS: In 2023, ASHM Health assembled a committee to create guidelines, based on existing international guidelines and utilizing data from the Study of the Prevention of Anal Cancer (SPANC). SPANC provided Australian-specific data on different screening methodologies for the detection of anal high-grade squamous intraepithelial lesions. RESULTS: The guidelines were released in March 2025. They recommend primary high-risk human papillomavirus (HRHPV) testing with cytology triage for high-resolution anoscopy. Gay, bisexual and other men who have sex with men (GBM) and trans-women living with HIV sh…
PMID 41130598Sex and human papillomavirus in oropharyngeal cancer: A systematic review and meta-analysis.
American journal of otolaryngology · 2024
INTRODUCTION: While the presence of human papillomavirus (HPV) is known to affect the outcomes of oropharyngeal squamous cell carcinoma (OPSCC), there is a significant gap in research regarding the potential sex-based differences. This systematic review-metanalysis (SR-MA) aims to evaluate if sex is a prognostic factor in HPV-associated OPSCC. METHODS: A systematic review and meta-analysis was performed. COCHRANE Library, CINAHL, PubMed, and Scopus were searched for English-language articles from 1966 to October 2023. Studies with multivariable analysis of overall survival (OS) based on sex were included. Adjusted hazard ratios (aHRs) with a 95 % confidence interval (CI) were presented for t…
PMID 39106680Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative.
Obstetrics and gynecology · 2026
The Women's Preventive Services Initiative (WPSI) expanded its previous cervical cancer screening recommendation for average-risk women by including patient-collected high-risk human papillomavirus (hrHPV) screening tests and additional follow-up testing needed to complete the screening process. To update the previous recommendation, the WPSI identified new evidence demonstrating that primary hrHPV screening increases detection of precancerous lesions compared with cytology screening. New studies indicate that patient-collected hrHPV testing has similar test accuracy for precancer detection compared with clinician-collected samples and may reduce barriers to screening. Consistent with the pr…
PMID 42024880SEOM-TTCC clinical guidelines for the treatment of head and neck cancer (2025).
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
Squamous cell carcinoma of the lip, oral cavity, oropharynx, hypopharynx, and larynx comprises the ninth most common cancer in Spain. While alcohol and tobacco use have long been the primary etiological factors, the role of human papillomavirus (HPV) in oropharyngeal cancer is increasing. Diagnoses and relapses should always be discussed by an expert multidisciplinary team. For localized stages, surgery or radiotherapy should be used as single-modality treatments, while locoregional stages require combined modality approaches. In the case of recurrent or metastatic disease, curative intent should be considered for patients with local recurrence or oligometastatic disease, while systemic trea…
PMID 41843267Updated clinical practice guidelines for human papillomavirus vaccination: the Korean Society of Gynecologic Oncology recommendations.
Journal of gynecologic oncology · 2026
The Korean Society of Gynecologic Oncology (KSGO) first developed clinical guidelines for the appropriate administration of human papillomavirus (HPV) vaccines tailored to the Korean context in 2016. In 2019, additional guidelines were introduced following the development of the nonavalent HPV vaccine. The 2021 revision included recommendations for vaccination in middle-aged women and men, as well as the potential benefits of vaccination following conization. In this latest revision, the guidelines focus on the necessity of HPV vaccination in middle-aged men, the Society's position on the single-dose schedule recently recommended by the World Health Organization to expand global vaccine cove…
PMID 41775253Comparative performance of HPV self-sampling and conventional screening methods: A systematic review and bivariate meta-analysis.
Gynecologic oncology · 2026
BACKGROUND: Cervical cancer is a major public health challenge, especially in low-resource settings with suboptimal screening. HPV self-sampling (SS) is a promising strategy to overcome logistical barriers, but its diagnostic accuracy relative to clinician-collected (CC) sampling, Visual Inspection with Acetic Acid (VIA), and Papanicolaou (Pap) cytology requires rigorous validation. METHODS: Following PRISMA-DTA guidelines, we searched PubMed/Medline, Scopus, Embase, and the Cochrane Library through March 2025 for studies comparing high-risk HPV SS against CC, VIA, or Pap cytology, using biopsy-confirmed CIN2+ as the reference standard. A bivariate random-effects model pooled sensitivity and…
PMID 42217258Role of radiotherapy in the management of anal canal cancer: Recommendations of the Société française de radiothérapie oncologique.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2025
We present the updated recommendations from the Société française de radiothérapie oncologique (SFRO, the French society for radiation oncology) regarding the use of external beam radiotherapy and brachytherapy in the management of anal cancer. Anal cancer is a rare malignancy with an increasing incidence, largely due to the high prevalence of Human papillomavirus infection. It primarily affects females over 65years of age. The most common histological type is squamous cell carcinoma. The standard treatment involves a combination of intensity-modulated radiotherapy and concurrent chemotherapy with 5-fluorouracil (or capecitabine) and mitomycin. A localized boost dose to the tumour can be del…
PMID 41273885[Cervical cancer screening : implementation of the hr-HPV test].
Revue medicale de Liege · 2025
Cervical cancer remains the fourth most common cancer in women. Recognition of the involvement of viral infection by human papillomavirus (HPV) in the carcinogenesis of lesions has enabled the evolution and adaptation of screening methods. Early detection of pre-invasive lesions and their treatment ultimately led to a reduction in the incidence and mortality of cervical cancer. In Belgium, the transition to primary screening is validated since January 1st, 2025. Let us nevertheless remember the importance of primary prevention through recommended vaccination for girls and boys.
PMID 41229231Radiotherapy for penile cancers: 2025 update.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2025
This article presents an update of the French national guidelines for the management of penile cancer, with recommendations on dose and volume for radiotherapy and brachytherapy. Multidisciplinary management and centralization in high-level of expertise centres is key for the management of this rare malignancy. For patients at high-risk of having micrometastatic disease (stage T1b or higher), a dynamic sentinel node biopsy should be offered as surgical staging and human papillomavirus status should be obtained. Organ-preservation with brachytherapy should be discussed whenever it is possible (tumours limited to the glans). For locoregionally advanced diseases, chemoradiotherapy as primary tr…
PMID 4120545003
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04
Treatment Options Studied in the PubMed Collection
These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.
higher-confidence evidence
Papillomavirus Vaccines
140 linked PMIDs1223425 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- reported clinical outcomes, cervical cancer, mortality, adverse events, CIN2+, serious adverse events, genital warts, vaccine effectiveness
- Populations represented
- general population; children; CIN2; HPV16; HPV18; HPV DNA; genital HPV infection
- Mechanism
- This study examined how current pharmacy vaccination practices align with parent expectations and identified modifiable behavioral and implementation targets to improve uptake WeChat-based interventions guided by the Information - Motivation - Behavioral Skills (IMB) model offer a theory-driven approach by targeting knowledge, motivation, social norms, and self-efficacy
higher-confidence evidence
HPV vaccine
82 linked PMIDs111968 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- reported clinical outcomes, cervical cancer, adverse events, vaccine effectiveness, CIN2+, recurrence, serious adverse events, persistent infection
- Populations represented
- general population; children; HPV16; HPV18; genital HPV infection; HPV16; CIN2; previously treated; HPV DNA
- Mechanism
- This study examined how current pharmacy vaccination practices align with parent expectations and identified modifiable behavioral and implementation targets to improve uptake WeChat-based interventions guided by the Information - Motivation - Behavioral Skills (IMB) model offer a theory-driven approach by targeting knowledge, motivation, social norms, and self-efficacy
preliminary evidence
DNA, Viral
25 linked PMIDs8402 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- reported clinical outcomes, cervical cancer, disease-free survival, recurrence, persistent infection, vaccine effectiveness, CIN3+, CIN2+
- Populations represented
- general population; advanced; HPV DNA; HPV DNA; HPV DNA; p16; HPV16; HPV18; stage I; HPV DNA
- Mechanism
- Furthermore, while current assays exploit the analytical simplicity of viral targets, host-derived fragmentomics remains an overlooked compartment that warrants exploration to determine its true clinical value regarding underlying tumor dynamics METHODS AND RESULTS: A new set of primers targeting amplification of approximately 391 base pairs of the L1 capsid protein gene of camel papillomavirus was designed, and PCR conditions were optimized
preliminary evidence
Biomarkers, Tumor
17 linked PMIDs76941 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- reported clinical outcomes, CIN2+, CIN3+, cervical cancer, overall survival, pathological complete response, recurrence, quality of life
- Populations represented
- general population; p16; CIN2; CIN3; high-risk HPV infection; p16; CIN3; high-risk HPV infection; metastatic
- Mechanism
- Furthermore, while current assays exploit the analytical simplicity of viral targets, host-derived fragmentomics remains an overlooked compartment that warrants exploration to determine its true clinical value regarding underlying tumor dynamics Notably, TRMT112 expression inversely correlated with cytotoxic T-cell infiltration, mechanistically linking it to the formation of "cold" tumors
preliminary evidence
Oncogene Proteins, Viral
14 linked PMIDs2533 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- cervical cancer, reported clinical outcomes, persistent infection, recurrence
- Populations represented
- general population; HPV16; metastatic; HPV16; HPV18
- Mechanism
- We developed two HPV genotyping assays targeting L1 and E6/E7 regions, respectively, using the same MeltArray platform to minimize technical variability These findings support their interchangeable use in cervical cancer screening, with both targets demonstrating high reliability across the full spectrum of cervical lesions.IMPORTANCEHuman papillomavirus (HPV) testing is the principal strategy for cervical cancer screening, with most commercially available assays targeting either the L1 gene or the E6/E7 oncogenes
moderate-confidence evidence
human papillomavirus vaccine
9 linked PMIDs1005098 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- reported clinical outcomes, adverse events, serious adverse events, cervical cancer
- Populations represented
- general population; high-risk HPV infection; children
- Mechanism
- RESULTS: Vaccination induced robust neutralizing antibody responses against four HPV types in both seronegative and seropositive participants In the baseline seropositive group, more than 91% of participants achieved a ≥4-fold increase in neutralizing antibody titers for all four HPV types
preliminary evidence
E6 protein, Human papillomavirus type 16
7 linked PMIDs56 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- cervical cancer, reported clinical outcomes, recurrence, persistent infection
- Populations represented
- HPV16; metastatic; HPV16
- Mechanism
- H101, a recombinant human adenovirus type 5, is a potential anticancer agent and has demonstrated therapeutic effects in gynecological diseases; however, its efficacy and mechanism of action remain unclear Molecular docking revealed strong binding affinities of probiotic-derived metabolites, particularly butyrate and bacteriocins, toward HPV16 E6 and E7 proteins, suggesting potential inhibition of viral oncogenic activity
preliminary evidence
Repressor Proteins
7 linked PMIDs56 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- cervical cancer, reported clinical outcomes, recurrence, persistent infection
- Populations represented
- HPV16; metastatic; HPV16
- Mechanism
- H101, a recombinant human adenovirus type 5, is a potential anticancer agent and has demonstrated therapeutic effects in gynecological diseases; however, its efficacy and mechanism of action remain unclear Molecular docking revealed strong binding affinities of probiotic-derived metabolites, particularly butyrate and bacteriocins, toward HPV16 E6 and E7 proteins, suggesting potential inhibition of viral oncogenic activity
preliminary evidence
Papillomavirus E7 Proteins
7 linked PMIDs56 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- cervical cancer, persistent infection, reported clinical outcomes, recurrence
- Populations represented
- HPV16; metastatic; HPV16; early-stage
- Mechanism
- H101, a recombinant human adenovirus type 5, is a potential anticancer agent and has demonstrated therapeutic effects in gynecological diseases; however, its efficacy and mechanism of action remain unclear The agonists in cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway have demonstrated robust immune activation in preclinical models
preliminary evidence
Cyclin-Dependent Kinase Inhibitor p16
6 linked PMIDs26829 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- CIN3+, cervical cancer, reported clinical outcomes, CIN2+, overall survival, disease-free survival, recurrence
- Populations represented
- p16; CIN3; HPV DNA; p16; p16; CIN2; CIN3; p16; stage III; p16; metastatic; p16
- Mechanism
- Not explicitly reported in the retrieved PubMed metadata or abstracts.
moderate-confidence evidence
Antibodies, Viral
6 linked PMIDs2799 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- cervical cancer, reported clinical outcomes, adverse events, serious adverse events
- Populations represented
- HPV16; HPV18; general population; HPV16
- Mechanism
- RESULTS: Vaccination induced robust neutralizing antibody responses against four HPV types in both seronegative and seropositive participants In the baseline seropositive group, more than 91% of participants achieved a ≥4-fold increase in neutralizing antibody titers for all four HPV types
preliminary evidence
PAX1 transcription factor
5 linked PMIDs9053 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- CIN2+, CIN3+, cervical cancer
- Populations represented
- CIN2; CIN3; HPV16; CIN3; HPV16; CIN2; CIN3; CIN2
- Mechanism
- Not explicitly reported in the retrieved PubMed metadata or abstracts.
preliminary evidence
Paired Box Transcription Factors
5 linked PMIDs9053 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- CIN2+, CIN3+, cervical cancer
- Populations represented
- CIN2; CIN3; HPV16; CIN3; HPV16; CIN2; CIN3; CIN2
- Mechanism
- Not explicitly reported in the retrieved PubMed metadata or abstracts.
preliminary evidence
Photosensitizing Agents
5 linked PMIDs4438 reported cumulative sample signal
- Research status
- mostly neutral
- Outcomes represented
- HPV clearance, response rate, recurrence, adverse events, cervical cancer, quality of life
- Populations represented
- CIN2; general population
- Mechanism
- METHODS: A systematic search was performed across PubMed, EMBASE, Web of Science, and the Cochrane Library from 2000 to 2025, targeting RCTs that compared PDT with standard conization methods or placebo
moderate-confidence evidence
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
4 linked PMIDs1967 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- adverse events, cervical cancer, serious adverse events, vaccine effectiveness
- Populations represented
- general population; HPV16; HPV18
- Mechanism
- RESULTS: Vaccination induced robust neutralizing antibody responses against four HPV types in both seronegative and seropositive participants In the baseline seropositive group, more than 91% of participants achieved a ≥4-fold increase in neutralizing antibody titers for all four HPV types
preliminary evidence
loop electrosurgical excision procedure
4 linked PMIDs1962 reported cumulative sample signal
- Research status
- mostly neutral
- Outcomes represented
- reported clinical outcomes, cervical cancer
- Populations represented
- general population; CIN2
- Mechanism
- Not explicitly reported in the retrieved PubMed metadata or abstracts.
moderate-confidence evidence
9-valent HPV vaccine
4 linked PMIDs840 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- cervical cancer, reported clinical outcomes, adverse events, serious adverse events
- Populations represented
- general population
- Mechanism
- Not explicitly reported in the retrieved PubMed metadata or abstracts.
preliminary evidence
bivalent HPV vaccine
4 linked PMIDs480 reported cumulative sample signal
- Research status
- insufficiently reported
- Outcomes represented
- reported clinical outcomes, adverse events, serious adverse events
- Populations represented
- general population
- Mechanism
- Not explicitly reported in the retrieved PubMed metadata or abstracts.
05
Conflicting Research
higher-confidence evidence
121 studiesPapillomavirus Vaccines · multiple reported outcomes
Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.
- The records use different or inconsistently reported comparators.
- The records report different endpoints or outcome definitions.
- The evidence combines different study designs.
- Some abstracts do not state whether the primary endpoint was met.
unknown: 109harm: 3benefit: 1null: 7mixed: 1
higher-confidence evidence
72 studiesHPV vaccine · multiple reported outcomes
Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.
- The records use different or inconsistently reported comparators.
- The records report different endpoints or outcome definitions.
- The evidence combines different study designs.
- Some abstracts do not state whether the primary endpoint was met.
unknown: 67null: 4mixed: 1
preliminary evidence
3 studiesPhotosensitizing Agents · multiple reported outcomes
Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.
- The records use different or inconsistently reported comparators.
- The records report different endpoints or outcome definitions.
- The evidence combines different study designs.
- Some abstracts do not state whether the primary endpoint was met.
null: 1benefit: 1unknown: 1
moderate-confidence evidence
1 studiesSuppositories · reported clinical outcomes
Status: mixed evidence. Population: high-risk HPV infection; HPV16; HPV18. Comparator: group A (P < 0.001), and there.
- Some abstracts do not state whether the primary endpoint was met.
mixed: 1
moderate-confidence evidence
1 studiesPlant Oils · reported clinical outcomes
Status: mixed evidence. Population: high-risk HPV infection; HPV16; HPV18. Comparator: group A (P < 0.001), and there.
- Some abstracts do not state whether the primary endpoint was met.
mixed: 1
06
Failed or Negative Trials
Design and initial findings of a natural history study of anal HPV and associated lesions among young adult women in Costa Rica.
randomized controlled trial · 2025 · PMID 40815549
Ripple effect of temporary self-sampling HPV test on screening uptake in the next round: A secondary analysis of the ACCESS randomized controlled trial.
randomized controlled trial · 2026 · PMID 40567147
HPV Testing Versus Cytology for Cervical Cancer Screening Among Women 50 Years and Older: Evidence From the HPV FOCAL Randomized Controlled Trial.
randomized controlled trial · 2026 · PMID 42363777
Randomized Controlled Trial of Impact of Mobile Health Technologies on Human Papillomavirus Vaccination Uptake in Mothers of Vaccine-Eligible Girls in Lagos, Nigeria (mHealth-HPVac).
randomized controlled trial · 2025 · PMID 40924973
The importance of spontaneous thought in the willingness to receive the human papillomavirus vaccine.
randomized controlled trial · 2025 · PMID 40712321
Induction Nivolumab Before Chemoradiation in High-Risk Human Papillomavirus-Driven Oropharynx Cancers: IMMUNEBOOST-HPV, a Multicenter Randomized Phase II Trial.
randomized controlled trial · 2026 · PMID 41570275
Genotype distribution of human papillomavirus (HPV) types in oral gargle specimens among men living with HIV in Mexico, Brazil, and Puerto Rico: A cross-sectional study.
randomized controlled trial · 2026 · PMID 42070588
Postoperative Radiotherapy ± Cetuximab for Intermediate-Risk Head and Neck Cancer.
randomized controlled trial · 2025 · PMID 39841939
A multicentre pragmatic randomized controlled trial comparing 50% salicylic acid, liquid nitrogen, 5% 5-fluorouracil cream, and 5% imiquimod cream in previously treated plantar warts. The VRAIE (VeRrues plAntaIres en villE) study.
randomized controlled trial · 2025 · PMID 40743833
Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial.
randomized controlled trial · 2025 · PMID 40079944
07
Emerging and Experimental Research
Video-based interventions to promote HPV vaccination among individuals aged 9 to 26: a systematic review and meta-analysis.
meta analysis · 2026 · PMID 41826914
Comparing paclitaxel and platinum-based concurrent chemoradiotherapy with short-term adjuvant chemotherapy versus platinum-based monotherapy concurrent chemoradiotherapy in patients with postoperative gastric-type endocervical adenocarcinoma with high-risk factors for recurrence: a multicenter randomized phase III trial.
randomized controlled trial · 2026 · PMID 41834413
Induction Nivolumab Before Chemoradiation in High-Risk Human Papillomavirus-Driven Oropharynx Cancers: IMMUNEBOOST-HPV, a Multicenter Randomized Phase II Trial.
randomized controlled trial · 2026 · PMID 41570275
Immunogenicity and safety of a quadrivalent recombinant human papillomavirus vaccine (type 6/11/16/18) (Hansenula polymorpha): A randomized controlled phase 2 non-inferiority clinical trial.
randomized controlled trial · 2026 · PMID 41932289
Efficacy and safety of a topical nitric oxide-releasing solution (NORS) as a noninvasive treatment for plantar warts (verrucae plantaris).
randomized controlled trial · 2026 · PMID 41493215
Effectiveness of different educational interventions on knowledge, attitude and willingness to undergo cervical cancer screening in rural Indonesia: a quasi-experimental study.
randomized controlled trial · 2026 · PMID 42575548
A Phase 1b/2, Randomised, Placebo-controlled Study to Evaluate Safety, Tolerability, Efficacy, and Immunogenicity of VTP-200, a Chimpanzee Adenovirus and Modified Vaccinia Ankara-vectored Multigenotype High-risk Human Papillomavirus Vaccine in Women With Low-grade Cervical Lesions.
randomized controlled trial · 2026 · PMID 41403292
The effect of podcasts delivered to female university students on HPV knowledge, awareness, and anxiety levels: A randomized controlled trial.
randomized controlled trial · 2026 · PMID 42314452
A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence.
randomized controlled trial · 2026 · PMID 42249801
Technological innovations in head and neck radiotherapy: What does the future hold?
preclinical or laboratory · 2026 · PMID 42001737
08
Evidence Gaps
Detailed risk-of-bias assessment remains limited
PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.
R
Complete Ranked PubMed Index
The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.
Current Standard Of Care65 records
Rank116.6
Screening for Cervical Cancer.
Obstetrics and gynecology · 2026 · PMID 42024877
This committee statement announces the American College of Obstetricians & Gynecologists' qualified endorsement of the 2026 Women's Preventive Services Initiative's (WPSI) updated cervical cancer screening guidelines and addresses cervical cancer screening for patients at average risk in the following age categories: 21-29 years, 30-65 years, and older than 65 years. This committee statement discusses specific qualifications to the WPSI guidelines, particularly regarding self-collection for primary high-risk human …
Rank113.0
2024 recommendations for the therapeutic management of anogenital warts.
Annales de dermatologie et de venereologie · 2026 · PMID 42235479
INTRODUCTION: Anogenital warts (AGW) are benign epithelial skin lesions caused mainly by the human papillomavirus (HPV, types 6 and 11) but are sometimes associated with other oncogenic HPV types. They have a high rate of post-treatment recurrence. There are many guidelines, but they do not prioritise treatments. Therapeutics are classified as either self-administered or clinician applied. The aim of this study was to propose recommendations for the management of AGW. METHOD: These recommendations were based on a s…
Rank112.0
International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 report on Terminology, Grading, and Molecular Testing Practices.
The American journal of surgical pathology · 2026 · PMID 40826809
The classification and diagnosis of penile intraepithelial neoplasia (PeIN) remains inconsistent among pathologists, despite its recognized role and understanding as a precursor to penile squamous cell carcinoma (PSCC). The International Society of Urological Pathology (ISUP) convened a consensus group of multidisciplinary thought leaders to assess current global practices regarding the usage of terminology, grading, and molecular testing in penile cancer precursor lesions. A preconference survey was distributed to…
Rank112.0
Clinical practice guideline for high-risk human papillomavirus testing in cervical cancer screening: a consensus statement from the Korean Society of Gynecologic Oncology.
Journal of gynecologic oncology · 2026 · PMID 41834415
High-risk human papillomavirus (hrHPV) is a necessary cause of cervical cancer, and hrHPV testing has increasingly been recognized as an effective screening tool that overcomes the limitations of cytology-based screening. However, standardized clinical guidance for the use of hrHPV testing in cervical cancer screening has been limited in Korea, resulting in variability in clinical practice. This consensus-based clinical practice guideline was developed under the auspices of the Korean Society of Gynecologic Oncolog…
Rank112.0
Australian guidelines for anal cancer screening using anal human papillomavirus testing with cytology triage in people living with HIV.
HIV medicine · 2025 · PMID 41130598
OBJECTIVES: To develop Australian anal cancer screening guidelines for people living with HIV. METHODS: In 2023, ASHM Health assembled a committee to create guidelines, based on existing international guidelines and utilizing data from the Study of the Prevention of Anal Cancer (SPANC). SPANC provided Australian-specific data on different screening methodologies for the detection of anal high-grade squamous intraepithelial lesions. RESULTS: The guidelines were released in March 2025. They recommend primary high-ris…
Rank110.0
Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative.
Obstetrics and gynecology · 2026 · PMID 42024880
The Women's Preventive Services Initiative (WPSI) expanded its previous cervical cancer screening recommendation for average-risk women by including patient-collected high-risk human papillomavirus (hrHPV) screening tests and additional follow-up testing needed to complete the screening process. To update the previous recommendation, the WPSI identified new evidence demonstrating that primary hrHPV screening increases detection of precancerous lesions compared with cytology screening. New studies indicate that pati…
Rank110.0
Role of radiotherapy in the management of anal canal cancer: Recommendations of the Société française de radiothérapie oncologique.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2025 · PMID 41273885
We present the updated recommendations from the Société française de radiothérapie oncologique (SFRO, the French society for radiation oncology) regarding the use of external beam radiotherapy and brachytherapy in the management of anal cancer. Anal cancer is a rare malignancy with an increasing incidence, largely due to the high prevalence of Human papillomavirus infection. It primarily affects females over 65years of age. The most common histological type is squamous cell carcinoma. The standard treatment involve…
Rank110.0
High-Risk HPV Testing in Head and Neck Carcinoma: Key Updates from the 2025 College of American Pathologists Guideline.
Head and neck pathology · 2025 · PMID 41021082
High-risk human papillomavirus (HPV) plays a significant role in the pathogenesis of certain head and neck (HN) cancers, especially squamous cell carcinomas (SCC) arising in the oropharynx. Distinction between HPV-independent and HPV-associated HNSCC has important implications for clinical management and patient prognosis in specific anatomic subsites of the head and neck. In 2018, the College of American Pathologists (CAP) issued 14 evidence-based guideline statements related to the testing, application, interpret…
Rank110.0
[Cervical cancer screening : implementation of the hr-HPV test].
Revue medicale de Liege · 2025 · PMID 41229231
Cervical cancer remains the fourth most common cancer in women. Recognition of the involvement of viral infection by human papillomavirus (HPV) in the carcinogenesis of lesions has enabled the evolution and adaptation of screening methods. Early detection of pre-invasive lesions and their treatment ultimately led to a reduction in the incidence and mortality of cervical cancer. In Belgium, the transition to primary screening is validated since January 1st, 2025. Let us nevertheless remember the importance of primar…
Rank110.0
Radiotherapy for penile cancers: 2025 update.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2025 · PMID 41205450
This article presents an update of the French national guidelines for the management of penile cancer, with recommendations on dose and volume for radiotherapy and brachytherapy. Multidisciplinary management and centralization in high-level of expertise centres is key for the management of this rare malignancy. For patients at high-risk of having micrometastatic disease (stage T1b or higher), a dynamic sentinel node biopsy should be offered as surgical staging and human papillomavirus status should be obtained. Org…
Rank110.0
Management of women with abnormal cervical cytology: Update of French guidelines after the implementation of HPV screening.
European journal of obstetrics, gynecology, and reproductive biology · 2025 · PMID 40957151
OBJECTIVE: To update the French national cancer institute (INCa) guidelines for the management of women with abnormal cervical cytology. METHODS: In 2016, INCa published guidelines for the management of women with abnormal cervical cytology. In 2019, however, the national authority for Health (HAS) recommended that the test for human papillomavirus be used to screen for cervical cancer in women over 30. It therefore became necessary to update the initial management and follow-up of women who had a positive test fol…
Rank110.0
Updated clinical practice guidelines for human papillomavirus vaccination: the Korean Society of Gynecologic Oncology recommendations.
Journal of gynecologic oncology · 2026 · PMID 41775253
The Korean Society of Gynecologic Oncology (KSGO) first developed clinical guidelines for the appropriate administration of human papillomavirus (HPV) vaccines tailored to the Korean context in 2016. In 2019, additional guidelines were introduced following the development of the nonavalent HPV vaccine. The 2021 revision included recommendations for vaccination in middle-aged women and men, as well as the potential benefits of vaccination following conization. In this latest revision, the guidelines focus on the nec…
Rank110.0
SEOM-TTCC clinical guidelines for the treatment of head and neck cancer (2025).
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026 · PMID 41843267
Squamous cell carcinoma of the lip, oral cavity, oropharynx, hypopharynx, and larynx comprises the ninth most common cancer in Spain. While alcohol and tobacco use have long been the primary etiological factors, the role of human papillomavirus (HPV) in oropharyngeal cancer is increasing. Diagnoses and relapses should always be discussed by an expert multidisciplinary team. For localized stages, surgery or radiotherapy should be used as single-modality treatments, while locoregional stages require combined modality…
Rank109.4
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis.
European journal of cancer (Oxford, England : 1990) · 2026 · PMID 42235467
BACKGROUND: Human papillomavirus (HPV)-based cervical screening offers stronger protection against cervical intraepithelial neoplasia (CIN) than screening with cytology. DNA methylation tests have been proposed as an alternative triage test to cytology, although there is currently no consensus on the most accurate gene or gene panels ("markers"). METHODS: We conducted a meta-analysis of accuracy of human and HPV methylation markers to detect CIN2 or worse (CIN2+), CIN3+, and cervical cancer (CRD42022299760). We sys…
Rank108.0
Italian guidelines for cervical cancer screening. Multisocietal recommendations on the use of biomarkers in HPV screening with risk-based approach and GRADE methodology.
British journal of cancer · 2025 · PMID 40931128
The European Council recommends adopting risk-based screening when relevant. In triaging HPV-positive women, it can be an effective strategy to reduce overtreatment and referral to colposcopy. HPV genotyping and p16/ki67 expression may allow a better risk stratification than cytology. In Italy, recommendations on their use (alone or combined) in screening were developed by a multi-professional (nine scientific societies) and multidisciplinary working group (including patients and decision makers). Grading of Recomm…
Rank108.0
Self-collected vaginal specimens for human papillomavirus testing and guidance on screening exit: An update to the American Cancer Society cervical cancer screening guideline.
CA: a cancer journal for clinicians · 2026 · PMID 41342729
This update expands the 2020 American Cancer Society (ACS) cervical cancer screening guideline for average-risk women and individuals with a cervix who are at average risk, to include self-collection for human papillomavirus (HPV) testing and revised guidance for exiting cervical cancer screening. Self-collected vaginal specimens, a method of primary HPV testing, align with the ACS cervical cancer screening guideline. When clinician-collected cervical specimens are used for HPV testing, repeat screening is recommen…
Rank107.4
The prognostic role of HPV status in penile squamous cell carcinoma: a systematic review and meta-analysis.
International journal of impotence research · 2025 · PMID 40770564
Penile squamous cell carcinoma (PSCC) is a rare but aggressive malignancy that can present as either Human papillomavirus (HPV)-associated or HPV-independent. Currently, there is no consensus on the prognostic value of HPV status in PSCC or its role in guiding treatment strategies. Therefore, in this systematic review and meta-analysis we aim to assess the impact of different methods of determining HPV status on cancer specific survival (CSS) and overall survival (OS) in patients with PSCC. Databases including MEDL…
Rank106.7
A Meta-analysis of Functional Outcomes and Recovery Metrics Comparing Transoral Robotic Surgery and (Chemo)Radiotherapy.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026 · PMID 41353736
OBJECTIVE: To assess patient outcomes with regard to swallowing, feeding tube dependence, tracheostomy use, pain levels, and recovery metrics between transoral robotic surgery and (chemo)radiotherapy. DATA SOURCES: Medline, EMBASE, Web of Science Core Collection, and the Cochrane Library. REVIEW METHODS: A meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines through a literature search of data sources (CRD42023464144). RESULTS: Sixteen stud…
Rank105.2
Efficacy and Safety of Ionic Contra-viral Therapy (Digoxin-furosemide) in the Treatment of Multiple Cutaneous Warts: A Systematic Review, Meta-analysis, and Trial Sequential Analysis.
Current drug research reviews · 2026 · PMID 40873359
INTRODUCTION: The primary objective of this systematic review was to evaluate the therapeutic efficacy and safety profile of intralesional Ionic Contra-Viral Therapy (ICVT)-a combination of digoxin and furosemide-in the treatment of multiple cutaneous warts. METHODS: This meta-analysis was conducted in accordance with PRISMA guidelines and was prospectively registered in PROSPERO (CRD42024544551). A comprehensive literature search was performed up to April 2024 across PubMed, MEDLINE, Scopus, Cochrane CENTRAL, Clin…
Rank103.2
Efficacy and Safety of Different Neoadjuvant Treatment Regimens in Locally Advanced Squamous Head and Neck Cancer.
Cancer reports (Hoboken, N.J.) · 2026 · PMID 41588993
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC), which constitutes approximately 90% of all head and neck cancers, represents a significant global health burden. A concerning trend is the rising incidence, particularly among younger populations, which has been partly attributed to human papillomavirus (HPV) infection. While treatment outcomes are favorable for early-stage disease, approximately 60% of patients are diagnosed with locally advanced HNSCC (LA-HNSCC), for whom prognosis remains suboptimal. Ind…
Rank102.8
Screening of human papilloma virus-related anogenital cancers in immunocompromised women: a systematic review of clinical practice guidelines.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025 · PMID 41086515
OBJECTIVE: Human papillomavirus-related anogenital cancers disproportionately affect immunocompromised patients due to poor clearance rates and accelerated oncogenicity. This systematic review compares anogenital cancer screening Clinical Practice Guidelines among different subpopulations of immunocompromised women. METHODS: We conducted a systematic review of guidelines addressing cervical, anal, vaginal, and vulvar cancer screening among immunocompromised women published between 2004 and 2025, following the Prefe…
Rank100.0
Rapid Systematic Review-Informed Multidisciplinary Expert Consensus on the Management of HPV-Positive Women with Low-Grade Cervical Lesions and the Role of a Coriolus versicolor-Based Vaginal Treatment.
Medicina (Kaunas, Lithuania) · 2026 · PMID 42512825
Background and Objectives: Persistent human papillomavirus (HPV) infection is associated with the development of cervical intraepithelial neoplasia and cervical cancer. In women with low-grade cervical lesions, a conservative management approach is commonly recommended. However, a subset of patients may experience lesion progression, which can also be accompanied by psychological distress. Adjuvant therapies during the surveillance period have gained increasing clinical interest. This consensus aims to provide mult…
Rank100.0
Computational approaches of modelling human papillomavirus transmission and prevention strategies: a systematic review.
Journal of biological dynamics · 2025 · PMID 39823279
Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the world. Persistent oncogenic HPV infection has been a leading threat to global health and can lead to serious complications such as cervical cancer. Prevention interventions including vaccination and screening have been proven effective in reducing the risk of HPV-related diseases. In recent decades, computational epidemiology has been serving as a very useful tool to study HPV transmission dynamics and evaluation of preven…
Rank85.0
Evaluation of the ESMO-magnitude of clinical benefit scale version 2.0 for the definitive treatment of HPV positive oropharynx cancer with radiation therapy.
Oral oncology · 2026 · PMID 42229021
BACKGROUND: The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a validated tool for assessing the clinical benefit of systemic cancer therapies. However, application of the scale to radiotherapy (RT) remains limited. As part of an ongoing initiative to adapt the scale for RT, we applied Form 1a of ESMO-MCBS v2.0 to studies cited in the American Society for Radiation Oncology (ASTRO) guideline for Human Papillomavirus (HPV)-positive oropharyngeal cancer (OPC) to assess feasi…
Rank77.8
Derivation and validation of the AJCC9V pathological stage classification for HPV-positive oropharyngeal carcinoma: a multicentre registry analysis.
The Lancet. Oncology · 2025 · PMID 40645195
BACKGROUND: Modernisation of the American Joint Committee on Cancer and Union for International Cancer Control (AJCC/UICC) staging for HPV-positive oropharyngeal carcinoma has strengthened its fundamental role to convey prognosis and guide treatment decisions. Implementation has nonetheless revealed imbalances. An AJCC committee reappraised HPV-positive oropharyngeal carcinoma pathological staging to advance prognostic accuracy and improve clinical applicability. METHODS: For this analysis, US registry data from th…
Diagnosis And Screening177 records
Rank107.8
Prevalence of cervical human papillomavirus infection among women in Ghana: a systematic review and meta-analysis.
BMC public health · 2026 · PMID 42251309
BACKGROUND: Cervical cancer remains a significant public health challenge, particularly in low and middle-income countries, where the burden is disproportionately high. Human papillomavirus (HPV) is the principal cause of cervical cancer, yet evidence on the national prevalence of HPV infection in Ghana remains fragmented and inconsistent across studies. As Ghana prepares to scale up HPV vaccination and expand HPV-based screening, a comprehensive synthesis of HPV prevalence is essential to inform policy and guide p…
Rank105.7
Global prevalence of cervical human papillomavirus in women aged 50 years and older with normal cytology: a systematic review and meta-analysis.
The Lancet. Microbe · 2025 · PMID 39622259
BACKGROUND: Given the paucity of up-to-date empirical data on human papillomavirus (HPV) among older women, we aimed to estimate the global HPV prevalence in women aged 50 years and older with normal cytology. METHODS: In this systematic review and meta-analysis, we searched for quantitative studies (cross-sectional, longitudinal, case-control, randomised control trials) reporting HPV prevalence among women aged 50 years and older with normal cytology published until May 31, 2022, in PubMed, Scopus, and Web of Scie…
Rank105.0
Diagnostic performance of PAX1 methylation as a biomarker for cervical lesions: a clinical study and meta-analysis.
Annals of medicine · 2025 · PMID 41229153
OBJECTIVE: To evaluate the diagnostic performance of PAX1 gene methylation in the detection of cervical lesions and assess its potential clinical application in cervical cancer screening through both a single-centre study and a meta-analysis. METHODS: A retrospective analysis was conducted on 329 patients who underwent concurrent ThinPrep cytologic test (TCT), high-risk HPV testing and PAX1 methylation analysis at the Affiliated Hospital of Jining Medical University. The diagnostic accuracy of PAX1 methylation for …
Rank103.0
Artificial intelligence in cervical cancer screening and triage: a role-stratified systematic review and bivariate meta-analysis.
Current opinion in oncology · 2026 · PMID 42343867
PURPOSE OF REVIEW: Artificial intelligence (AI) tools for cervical cancer screening have proliferated, but modality-pooled accuracy estimates conflate clinically distinct uses of AI. We re-examine this evidence base through a role-stratified bivariate meta-analysis to clarify where AI is ready for clinical translation and where gaps remain. RECENT FINDINGS: Of 97 eligible studies published between 2019 and 2026, 47 with reconstructible 2 × 2 data were pooled using a bivariate Reitsma model stratified by clinical ro…
Rank102.6
Association Between Male Circumcision and Cervical Cancer Risk: A Systematic Review and Meta-Analysis of Analytical Studies.
JCO global oncology · 2025 · PMID 41343744
PURPOSE: Cervical cancer is the second most commonly diagnosed cancer and one of the leading causes of death in women. The objective of the current review was to synthesize the available evidence on the association between male circumcision and risk of cervical cancer in females. METHODS: We searched PubMed, Cochrane, CancerLit, Google Scholar, medRxiv, bioRxiv, UpToDate, TRIP database, and the ProQuest Dissertations and Theses Global databases to identify relevant articles. We considered research studies that asse…
Rank102.2
Diagnostic accuracy of HPV DNA in oral gargle and rinse samples for Head and neck squamous cell carcinoma: A systematic review and meta-analysis.
The Japanese dental science review · 2026 · PMID 42211773
BACKGROUND: Early detection of head and neck squamous cell carcinoma (HNSCC) remains challenging because tissue biopsy is invasive and unsuitable for repeated monitoring or large-scale screening. This study systematically evaluated the diagnostic accuracy of human papillomavirus (HPV) DNA detection in oral gargle and rinse samples for HNSCC. METHODS: This meta-analysis followed PRISMA guidelines and included 10 studies with 1315 participants. Pooled sensitivity, specificity, summary receiver operating characteristi…
Rank100.0
Serious adverse events following human papillomavirus vaccination: A systematic review and meta-analysis of post-marketing evidence.
Human vaccines & immunotherapeutics · 2026 · PMID 41759030
Human papillomavirus (HPV) vaccines are a critical tool in cancer prevention, yet concerns about serious adverse events (SAEs) have fueled public hesitancy and constrained vaccination uptake. This systematic review aimed to determine the proportion of adverse events that were SAEs, rate of SAEs following HPV vaccination and their association from post-marketing observational studies. We conducted a search in PubMed, EMBASE, and Web of Science databases in March 2025. Studies published in English reporting SAEs afte…
Rank100.0
Cervical cancer screening strategies in women 65 years and older in the human papillomavirus era: A systematic review and meta-analysis of human papillomavirus-based testing and self-sampling approaches.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026 · PMID 41817023
BACKGROUND: Cervical cancer elimination efforts increasingly rely on human papillomavirus (HPV)-based screening. However, the optimal approach to screening beyond age 65 years and the role of self-sampling in older women remain uncertain in the HPV era. OBJECTIVES: To evaluate HPV-based cervical cancer screening strategies, including self-sampling, in women aged 65 years and older and to quantify outcomes relevant to extended-age or "catch-up" approaches. SEARCH STRATEGY: We searched major bibliographic databases f…
Rank100.0
Cost-effectiveness modeling for gender-neutral human papillomavirus vaccines: A systematic literature review.
Human vaccines & immunotherapeutics · 2025 · PMID 40665636
Gender-neutral vaccination (GNV) of human papillomavirus (HPV) may help reduce the transmission and incidence of HPV-related diseases. However, approximately 40 countries have implemented HPV GNV schedules. We systematically evaluated HPV GNV cost-effectiveness models from January 2008 to May 2024 using MEDLINE, Embase, and Cochrane to identify key drivers of cost-effectiveness results. Fifty-three publications were included, primarily from high-income countries. Vaccine coverage, price, protection duration, and di…
Rank100.0
Update on completed and ongoing trials investigating TORS in head and neck oncology.
Frontiers in oncology · 2026 · PMID 42682574
BACKGROUND: Human papillomavirus (HPV) has substantially altered the epidemiology and prognosis of oropharyngeal squamous cell carcinomas (OPSCC), with an increasing incidence in younger patients and markedly improved survival outcomes. This shift presents an increasing clinical challenge: how to safely reduce treatment intensity, while maintaining cure and survival rates and minimizing therapy-related toxicity. Transoral robotic surgery (TORS) has emerged as a pivotal strategy in this context, with multiple clinic…
Rank99.6
HPV Testing Versus Cytology for Cervical Cancer Screening Among Women 50 Years and Older: Evidence From the HPV FOCAL Randomized Controlled Trial.
International journal of cancer · 2026 · PMID 42363777
Evidence on the comparative effectiveness of HPV testing versus cytology specifically in women aged ≥ 50 years who are approaching screening cessation remains limited. This analysis included 6471 women aged ≥ 50 at baseline screening in the HPV FOCAL randomized clinical trial. Women were randomly allocated to receive cytology (Control Group, n = 3248, 50.19%) or HPV testing (Intervention Group, n = 3223, 49.81%) at baseline, with co-testing at 48-month exit. We calculated incidence rates and risk ratios for CIN2+ d…
Rank98.0
International Papillomavirus Society statement on reputed treatments for human papillomavirus infection and human papillomavirus-related diseases: evidence, risks, and standards for clinical evaluation.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026 · PMID 42680631
Human papillomavirus is the most common sexually transmitted infection and the necessary cause of cervical cancer, as well as a proportion of other anogenital and oropharyngeal cancers. Although most infections clear spontaneously, persistent oncogenic human papillomavirus infection may lead to precancer and cancer. There is therefore a need for effective and globally accessible therapies that either promote sustained clearance of human papillomavirus infection or safely treat human papillomavirus-related lesions, …
Rank97.6
Efficacy and safety of a topical nitric oxide-releasing solution (NORS) as a noninvasive treatment for plantar warts (verrucae plantaris).
The Journal of dermatological treatment · 2026 · PMID 41493215
BACKGROUND: Plantar warts (verrucae plantaris), caused by human papillomavirus, are common and often resistant to standard therapies, which can be painful and damaging. Novel, noninvasive options are needed. OBJECTIVE: To evaluate the safety and preliminary efficacy of a topical nitric oxide-releasing solution (NORS) as a self-administered therapy for plantar warts. METHODS: In this Phase 2a, multicenter, randomized, double-blind, placebo-controlled trial, 20 participants with ≥3 plantar warts were randomized (1:1:…
Rank96.0
[The role of serological (rapid) tests for the early detection of HPV-related cancers].
Dermatologie (Heidelberg, Germany) · 2026 · PMID 42696122
Oncogenic human papillomaviruses (HPV), such as HPV16, can cause anogenital and oropharyngeal cancer (OPC). Unlike anogenital cancers, there are no known premalignant precursor lesions for HPV-induced OPC (HPV-OPC). While cytology-based and HPV-DNA/mRNA-based screening programs are recommended for anogenital cancers in the general population (cervical cancer) or for high-risk groups (anal cancer), this is not the case for HPV-OPC. This article summarizes the role of HPV serology for the early detection of HPV-OPC. …
Rank95.0
Evidence of Decreased Long-term Risk of Cervical Precancer after Negative Primary HPV Screens Compared with Negative Cytology Screens in a Longitudinal Cohort Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024 · PMID 38773687
BACKGROUND: The growing use of primary human papillomavirus (HPV) cervical cancer screening requires determining appropriate screening intervals to avoid overtreatment of transient disease. This study examined the long-term risk of cervical precancer after HPV screening to inform screening interval recommendations. METHODS: This longitudinal cohort study (British Columbia, Canada, 2008 to 2022) recruited women and individuals with a cervix who received 1 to 2 negative HPV screens (HPV1 cohort, N = 5,546; HPV2 cohor…
Rank89.4
Effectiveness of different educational interventions on knowledge, attitude and willingness to undergo cervical cancer screening in rural Indonesia: a quasi-experimental study.
BMJ open · 2026 · PMID 42575548
OBJECTIVES: The low uptake of cervical cancer screening (CCS) in rural areas is mainly related to the lack of awareness regarding cervical cancer. Using educational interventions has been shown to substantially improve knowledge and attitude towards cervical cancer, which are important determinants of undergoing CCS. The aim of this study was to analyse the impact of different educational intervention methods on knowledge, attitudes and willingness to undergo CCS among women in rural Indonesia. DESIGN: A quasi-expe…
Rank87.0
[Anal cancer screening: who, how, and why?].
Virologie (Montrouge, France) · 2026 · PMID 41789701
Although anal cancer remains rare in the general population, it is becoming more prevalent, particularly in high-income countries such as France, where the incidence rate is among the highest in the world. Over 90 % of anal cancers are caused by high-risk human papillomavirus (HR-HPV), particularly HPV16. Although two-thirds of cases occur in women, certain groups are at a higher risk, including men who have sex with men (MSM) living with HIV, women living with HIV, women with a history of high-grade vulvar lesions…
Rank85.0
Promise and Perils of Primary HPV Testing.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024 · PMID 39086313
Cervical cancer screening has reduced morbidity and mortality in many countries, but efforts to optimize screening modalities and schedules are ongoing. Using data from a randomized trial conducted in British Columbia, Canada, in conjunction with a provincial screening registry, Gottschlich and colleagues demonstrated that the estimated risk for precancerous disease (cervical intraepithelial neoplasia grades 2 or worse) at 8 years following a negative human papillomavirus (HPV) test was similar to the current stand…
Rank85.0
Assessment of atypical glandular cell interpretation in Pap tests using the Hologic Genius Digital Diagnostics System.
Cancer cytopathology · 2026 · PMID 42622122
Atypical glandular cells (AGC) are a diagnostic challenge. The aim of this study was to evaluate the efficacy and diagnostic performance of AGC detection on the Hologic Genius Digital Diagnostics System (HGDDS). A retrospective analysis of 451 ThinPrep Pap cases was conducted, including 207 cases of AGC, 27 cases of high-grade squamous intraepithelial lesion (HSIL), 25 cases of low-grade squamous intraepithelial lesion (LSIL), and 192 benign cases. All AGC cases had follow-up histologic diagnoses, with 66 cases sub…
Rank85.0
DNA Methylation Testing in Cervical Cancer: A Triage Tool for HPV-Based Screening and Post-Treatment Surveillance.
The journal of obstetrics and gynaecology research · 2026 · PMID 42681848
BACKGROUND: High-risk HPV screening achieves high sensitivity but low specificity, resulting in excessive colposcopy referrals. DNA methylation biomarkers could refine risk stratification across the cervical cancer care continuum. OBJECTIVE: To evaluate the diagnostic performance and clinical implementation of DNA methylation testing in HPV-positive triage and post-treatment surveillance. METHODS: Narrative review of prospective cohorts and randomized trials (2013-2024) evaluating methylation markers in cervical ca…
Rank82.9
HPV vaccine awareness and uptake among women attending cervical screening in health-resource-limited areas of China: A multicenter cross-sectional study.
Human vaccines & immunotherapeutics · 2026 · PMID 41830505
Evidence shows HPV vaccination reduces infection, precancer and cervical cancer, yet coverage in health-resource-limited of China remains uncertain. We assessed awareness, uptake and correlates among women attending cervical screening, and examined associations with screening outcomes. We conducted a cross-sectional study in eight county sites in 2023-2024 among women aged 35-64 y. A standardized questionnaire captured sociodemographic factors, awareness and vaccination. Cervical samples were tested for hrHPV. Outc…
Rank81.1
Phase 2 Prospective Trial of Personalized Radiation Therapy Fractionation in Human Papillomavirus Positive Oropharyngeal Cancer.
International journal of radiation oncology, biology, physics · 2026 · PMID 41519405
PURPOSE: We previously developed a model of pretreatment growth and on-treatment response dynamics, the proliferation saturation index (PSI) model, which derives the proliferating and radiosensitive proportion of a tumor based on clinically observed net growth before therapy. We hypothesized that personalization of fractionation using PSI would increase the percentage of patients achieving a rapid reduction in tumor size during radiation therapy (RT) for early-stage human papillomavirus related squamous cancers of …
Rank80.8
HPV testing with 16/18 genotyping for risk stratification among women with normal cytology: a multicenter prospective cohort study from China.
Journal of clinical microbiology · 2026 · PMID 41711488
UNLABELLED: To evaluate the clinical performance of Hybribio's 14-type HPV real-time PCR with 16/18 genotyping (HBRT-H14) and its risk stratification utility among women with normal cytology (NILM). From 2017 to 2020, a multicenter cohort enrolled 8,401 women aged 30-64 years with NILM cytology. Baseline HPV testing used HBRT-H14. Women positive for HPV 16/18 were referred for colposcopy; follow-up was annual for 3 years or until the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Analyses…
Rank70.0
Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay.
Molecular medicine (Cambridge, Mass.) · 2025 · PMID 40448246
BACKGROUND: Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human papillomaviruses (hrHPV), the causative agents of cervix cancer. Although hrHPV infection is a pre-requisite for the development of most precancerous lesions, the mere detection of viral nucleic acids, also present in transient infections, is not specific of the underlying cellular state, resulting in poor positive predictive values (PPV) regarding lesional states. The…
Rank69.9
Natural history of anal HSIL and predictive value of cytology and HPV biomarkers in MSM living with HIV: A prospective cohort study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42264069
OBJECTIVES: Men who have sex with men (MSM) living with HIV are at high risk for anal cancer, which arises from HPV-related high-grade squamous intraepithelial lesions (HSIL). This study describes natural history of HSIL and identifies predictors of incidence and clearance using HPV DNA and E6/E7 mRNA biomarkers. METHODS: Prospective cohort of 354 MSM with HIV, followed for 2-4 years. Visitsisits included anal cytology, HPV DNA/mRNA testing, and high-resolution anoscopy. Composite cytological and histological outco…
Evidence Syntheses98 records
Rank116.6
Screening for Cervical Cancer.
Obstetrics and gynecology · 2026 · PMID 42024877
This committee statement announces the American College of Obstetricians & Gynecologists' qualified endorsement of the 2026 Women's Preventive Services Initiative's (WPSI) updated cervical cancer screening guidelines and addresses cervical cancer screening for patients at average risk in the following age categories: 21-29 years, 30-65 years, and older than 65 years. This committee statement discusses specific qualifications to the WPSI guidelines, particularly regarding self-collection for primary high-risk human …
Rank113.0
2024 recommendations for the therapeutic management of anogenital warts.
Annales de dermatologie et de venereologie · 2026 · PMID 42235479
INTRODUCTION: Anogenital warts (AGW) are benign epithelial skin lesions caused mainly by the human papillomavirus (HPV, types 6 and 11) but are sometimes associated with other oncogenic HPV types. They have a high rate of post-treatment recurrence. There are many guidelines, but they do not prioritise treatments. Therapeutics are classified as either self-administered or clinician applied. The aim of this study was to propose recommendations for the management of AGW. METHOD: These recommendations were based on a s…
Rank110.0
Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative.
Obstetrics and gynecology · 2026 · PMID 42024880
The Women's Preventive Services Initiative (WPSI) expanded its previous cervical cancer screening recommendation for average-risk women by including patient-collected high-risk human papillomavirus (hrHPV) screening tests and additional follow-up testing needed to complete the screening process. To update the previous recommendation, the WPSI identified new evidence demonstrating that primary hrHPV screening increases detection of precancerous lesions compared with cytology screening. New studies indicate that pati…
Rank110.0
Cervical cancer screening among transgender and gender diverse individuals: a systematic review and meta-analysis.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026 · PMID 42497580
OBJECTIVE: To conduct a systematic review and meta-analysis of observational studies comparing cervical cancer screening participation and Pap cytology results between transgender/gender diverse individuals and cisgender female individuals. METHODS: MEDLINE, EMBASE, and CINAHL were searched from database inception to January 7, 2026, by 2 independent reviewers. Primary observational studies reporting up-to-date cervical cancer screening and/or Pap test results in transgender/gender diverse individuals with a cervix…
Rank110.0
SEOM-TTCC clinical guidelines for the treatment of head and neck cancer (2025).
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026 · PMID 41843267
Squamous cell carcinoma of the lip, oral cavity, oropharynx, hypopharynx, and larynx comprises the ninth most common cancer in Spain. While alcohol and tobacco use have long been the primary etiological factors, the role of human papillomavirus (HPV) in oropharyngeal cancer is increasing. Diagnoses and relapses should always be discussed by an expert multidisciplinary team. For localized stages, surgery or radiotherapy should be used as single-modality treatments, while locoregional stages require combined modality…
Rank110.0
Comparative performance of HPV self-sampling and conventional screening methods: A systematic review and bivariate meta-analysis.
Gynecologic oncology · 2026 · PMID 42217258
BACKGROUND: Cervical cancer is a major public health challenge, especially in low-resource settings with suboptimal screening. HPV self-sampling (SS) is a promising strategy to overcome logistical barriers, but its diagnostic accuracy relative to clinician-collected (CC) sampling, Visual Inspection with Acetic Acid (VIA), and Papanicolaou (Pap) cytology requires rigorous validation. METHODS: Following PRISMA-DTA guidelines, we searched PubMed/Medline, Scopus, Embase, and the Cochrane Library through March 2025 for …
Rank109.6
Global research trends and hotspots in human immunodeficiency virus-associated cervical cancer (1990-2025): a multi-database bibliometric analysis.
Frontiers in immunology · 2026 · PMID 42358990
BACKGROUND: Research on cervical cancer among WLWH represents a critical area for advancing long-term prevention and clinical management strategies. Yet as the volume of published literature in this field continues to grow rapidly, synthesizing and appraising the available evidence in a comprehensive manner has become increasingly challenging. OBJECTIVE: This study aims to map the global research landscape, identify leading contributors and collaborative networks, and delineate the knowledge base and emerging resea…
Rank109.4
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis.
European journal of cancer (Oxford, England : 1990) · 2026 · PMID 42235467
BACKGROUND: Human papillomavirus (HPV)-based cervical screening offers stronger protection against cervical intraepithelial neoplasia (CIN) than screening with cytology. DNA methylation tests have been proposed as an alternative triage test to cytology, although there is currently no consensus on the most accurate gene or gene panels ("markers"). METHODS: We conducted a meta-analysis of accuracy of human and HPV methylation markers to detect CIN2 or worse (CIN2+), CIN3+, and cervical cancer (CRD42022299760). We sys…
Rank109.3
Cervical cancer in the Arab world: knowledge gaps, health system and cultural barriers, and the path forward.
Cancer treatment and research communications · 2026 · PMID 42166863
BACKGROUND: Human Papillomavirus (HPV) is a sexually transmitted virus that infects the genital tract. High-risk HPVs are responsible for nearly all cervical cancer (CC). In the Arab world, uptake of CC screening by women is low. This study aims to investigate the key factors influencing the uptake of CC screening among women in Arab countries. METHODS: Search strategy for the systematic review was registered in PROSPERO: CRD420251034400 and followed PRISMA guidelines. PubMed, Embase, Web of Science, Cochrane, and …
Rank108.8
Intratumoral Human Papillomavirus in Advanced Prostate Cancer: Systematic Review, Meta-Analysis, and Real-World Evidence from the Largest Cohort to Date.
International journal of molecular sciences · 2026 · PMID 42737728
The etiopathogenesis of prostate cancer (PCa) is complex and involves multiple hormonal and environmental factors. Among these, the role of infectious agents remains controversial. Human papillomavirus (HPV) is known to promote carcinogenesis in epithelial tumors and has also been detected, albeit inconsistently, in PCa tissues. This systematic review, meta-analysis, and real-world cohort study aimed to clarify the prevalence and the prognostic role of intratumoral (IT)-HPV detection in locally advanced and metasta…
Rank108.8
P16/Ki67 dual staining versus cytology for identifying high-grade cervical intraepithelial neoplasia (CIN2+/CIN3+) in triage management of HR-HPV-positive women: a systematic review and meta-analysis.
Journal of gynecologic oncology · 2026 · PMID 41995269
OBJECTIVE: The co-expression of P16 and Ki67 suggests the presence of high-grade cervical intraepithelial neoplasia, which makes P16/Ki67 dual staining a promising marker in cervical cancer screening. This study provides a systemic review of the established evidence on the performance of P16/Ki67 versus cytology in detecting cervical intraepithelial neoplasia (CIN)2+/CIN3+ among high-risk human papillomavirus (HR-HPV)-positive women and HR-HPV-positive individuals with cytology-negative results for triage managemen…
Rank108.7
Human papillomavirus (HPV) vaccination in women with conisation.
The Cochrane database of systematic reviews · 2025 · PMID 40919695
RATIONALE: Cervical cancer is the fourth most common cancer affecting women worldwide, caused by persistent infection with oncogenic human papillomavirus (HPV) types. While HPV infections usually resolve spontaneously, persistent infections with high-risk HPV types can progress to premalignant glandular or - mostly - squamous intraepithelial lesions, usually classified in cervical intraepithelial neoplasia (CIN). Women with CIN 2 and CIN 3 (i.e. high-grade CIN) typically undergo cervical conisation to remove precan…
Rank108.4
Investigation of Blood Folate and Vitamin B12 Levels in Women With Human Papillomavirus: A Systematic Review.
Journal of lower genital tract disease · 2026 · PMID 42132147
OBJECTIVES: Human papillomavirus (HPV) is a highly prevalent sexually transmitted infection. Discussions have arisen regarding reduced vitamin levels in patients. This review aims to gather evidence on blood folate and vitamin B12 levels in women with HPV. METHODS: A comprehensive search was conducted across multiple electronic databases, including Web of Science, Embase, Scopus, and PubMed, using keywords such as "human papillomavirus," "folate," and "vitamin B12". Combinations derived from MeSH and Emtree terms w…
Rank108.4
The impact of HIV coinfection on mpox patients: a systematic review and meta-analysis.
Emerging microbes & infections · 2026 · PMID 42461714
A substantial proportion of mpox cases occur in people with HIV, but how HIV coinfection and immune status affect clinical outcomes remains unclear. We systematically searched major databases up to March 2025 for observational studies comparing mpox patients with and without HIV coinfection. Pooled effect sizes were calculated using random-effects models. Risk ratios (RRs) or standardized mean differences (SMDs) with 95% confidence intervals were used for dichotomous or continuous outcomes. Post hoc subgroup analys…
Rank108.3
Immunogenicity and safety of prophylactic HPV vaccines in people living with HIV: A systematic review and meta-analysis.
Human vaccines & immunotherapeutics · 2026 · PMID 42684271
Human papillomavirus (HPV) is a major global public health concern, causing genital warts and cancers of the cervix, anus, oropharynx, vulva, and penis. People living with HIV (PLWH) face a disproportionately elevated burden of HPV infection and HPV-related malignancies due to chronic immunosuppression. We conducted a systematic review and meta-analysis searching six databases from January 2006 to June 2026 without language restrictions. Twenty-five studies were included in the systematic review; 12 independent stu…
Rank107.9
Diagnostic Accuracy of Urine and Vaginal Self-Sampling for Detection of High-Risk Human Papillomavirus: A Systematic Review and Meta-Analysis.
Viruses · 2026 · PMID 42357689
Cervical cancer remains a major public health challenge, particularly in low- and middle-income countries. The primary cause of cervical cancer is high-risk human papillomavirus (HPV), and screening using physician-collected samples is complicated by stigma, inconvenience, and access. There are non-invasive alternatives to the physician-collected samples, including self-sampling methods such as first-void urine and vaginal swabs. This systematic review and meta-analysis evaluated and compared the diagnostic accurac…
Rank107.8
HPV circulating tumor DNA as a potential prognostic and predictive biomarker in head and neck squamous cell carcinoma: a systematic review.
Oral oncology · 2026 · PMID 42641201
PURPOSE: Human papillomavirus circulating tumor DNA (HPVctDNA) has emerged as a promising prognostic biomarker in HPV-related head and neck squamous cell carcinoma (HNSCC). This systematic review aimed to synthesize current evidence on the diagnostic accuracy and prognostic value of HPVctDNA in HNSCC management. MATERIAL/METHODS: We systematically reviewed a PubMed-indexed database of studies published between January 2012 and September 2025. Eligible studies were assessed for design, primary tumor site and stage, …
Rank107.8
Prevalence of cervical human papillomavirus infection among women in Ghana: a systematic review and meta-analysis.
BMC public health · 2026 · PMID 42251309
BACKGROUND: Cervical cancer remains a significant public health challenge, particularly in low and middle-income countries, where the burden is disproportionately high. Human papillomavirus (HPV) is the principal cause of cervical cancer, yet evidence on the national prevalence of HPV infection in Ghana remains fragmented and inconsistent across studies. As Ghana prepares to scale up HPV vaccination and expand HPV-based screening, a comprehensive synthesis of HPV prevalence is essential to inform policy and guide p…
Rank107.1
Diagnostic Performance of HPV Testing Using Self-Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta-Analysis.
The journal of obstetrics and gynaecology research · 2026 · PMID 42547988
AIM: Self-collection models are regarded as a potential strategy to facilitate HPV testing for cervical cancer screening. HPV testing using urine specimens offers certain advantages, including its noninvasiveness. This characteristic has the potential to eliminate discomfort. Concerns regarding the accuracy of this method persist. Thus, the present meta-analysis aims to verify the accuracy of HPV testing using self-collected urine samples and vaginal samples. METHODS: A literature search was conducted in the PubMed…
Rank107.1
Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for cervical squamous intraepithelial lesion: a systematic review and meta-analysis.
Lasers in medical science · 2026 · PMID 42470528
To evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for cervical squamous intraepithelial lesion (SIL). We systematically searched PubMed and other databases to compare the effectiveness of 5-ALA PDT with observation, ablation, and conization. Outcomes included overall response rate (ORR), complete remission (CR) rate, HPV clearance rate, and other relevant endpoints. Single-arm analyses were additionally performed by lesion grade. A total of 3,354 patients were included ac…
Rank107.1
Subsequent-line Systemic Therapy for Metastatic or Recurrent Penile Cancer: A Systematic Review of Efficacy, Toxicity, and Outcomes.
European urology focus · 2026 · PMID 41519649
BACKGROUND AND OBJECTIVE: Treatment options for metastatic or recurrent penile squamous cell carcinoma (PSCC) progressing after first-line platinum-based chemotherapy are limited, and no standard subsequent-line systemic therapy exists. We systematically reviewed the efficacy, safety, and survival outcomes of second- and later-line systemic treatments in this setting. METHODS: A systematic review, compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, was performed across …
Rank106.6
Effect of Smoking in Oropharyngeal Cancer Treated With TORS: Systematic Review and Meta-Analysis.
The Laryngoscope · 2026 · PMID 42103481
OBJECTIVE: While smoking has been implicated as a risk factor for recurrence in HPV-associated oropharyngeal squamous cell cancer (OPSCC) treated with definitive chemoradiation, its prognostic impact on surgically treated OPSCC is less clear. DATA SOURCES: MEDLINE, Embase, CENTRAL, and Scopus. REVIEW METHODS: Articles describing patients with HPV-associated OPSCC treated with transoral robotic surgery (TORS), which reported oncologic outcomes by smoking history, were included. RESULTS: 2079 patients were included a…
Rank106.4
De-Escalation Treatment Strategies in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An Umbrella Review of Systematic Reviews and Meta-Analyses.
Head & neck · 2026 · PMID 42230323
BACKGROUND: De-escalation strategies for human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) aim to reduce late morbidity while preserving cure rates, but evidence syntheses provide inconsistent conclusions and may be affected by overlap of primary studies. METHODS: We performed an umbrella review of systematic reviews (SRs) and meta-analyses (MAs) evaluating de-escalation approaches versus standard-of-care therapy in HPV-positive (or p16-positive) OPSCC. MEDLINE (PubMed), Embase, and …
Rank106.0
A meta-analysis of photodynamic therapy in the treatment of cervical intraepithelial neoplasia: Based on randomized controlled trials.
Photodiagnosis and photodynamic therapy · 2026 · PMID 41740824
OBJECTIVE: To systematically evaluate the efficacy and safety of photodynamic therapy (PDT) for HPV-infected cervical intraepithelial neoplasia (CIN) based on randomized controlled trials (RCTs). METHODS: A systematic search was performed across PubMed, EMBASE, Web of Science, and the Cochrane Library from 2000 to 2025, targeting RCTs that compared PDT with standard conization methods or placebo. The primary outcomes assessed included histopathological response, human papillomavirus (HPV) clearance, and the rate of…
Rank106.0
Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.
Medicine · 2026 · PMID 42363527
BACKGROUND: Despite the general advantages of neoadjuvant immunotherapy for locally advanced head and neck squamous cell carcinoma (LAHNSCC), many patients do not achieve successful clinical outcomes. Hitherto, there has been a lack of biomarkers to predict the effect of neoadjuvant immunotherapy in LAHNSCC. METHODS: We systematically searched PubMed, Embase, Web of Science, and Cochrane databases until June 2024 for studies related to neoadjuvant immunotherapy for LAHNSCC. We calculated the pathological response r…
Landmark Evidence52 records
Rank112.0
Sex and human papillomavirus in oropharyngeal cancer: A systematic review and meta-analysis.
American journal of otolaryngology · 2024 · PMID 39106680
INTRODUCTION: While the presence of human papillomavirus (HPV) is known to affect the outcomes of oropharyngeal squamous cell carcinoma (OPSCC), there is a significant gap in research regarding the potential sex-based differences. This systematic review-metanalysis (SR-MA) aims to evaluate if sex is a prognostic factor in HPV-associated OPSCC. METHODS: A systematic review and meta-analysis was performed. COCHRANE Library, CINAHL, PubMed, and Scopus were searched for English-language articles from 1966 to October 20…
Rank110.0
Human papillomavirus infection and the risk of cancer at specific sites other than anogenital tract and oropharyngeal region: an umbrella review.
EBioMedicine · 2024 · PMID 38744109
BACKGROUND: Despite numerous studies having evaluated the associations between human papillomavirus (HPV) infection and risk of specific cancers other than anogenital tract and oropharyngeal, the findings are inconsistent and the quality of evidence has not been systematically quantified. We aimed to summarise the existing evidence as well as to evaluate the strength and credibility of these associations. METHODS: We conducted an umbrella review of systematic reviews and meta-analyses of observational studies. PubM…
Rank108.7
Human papillomavirus (HPV) vaccination in women with conisation.
The Cochrane database of systematic reviews · 2025 · PMID 40919695
RATIONALE: Cervical cancer is the fourth most common cancer affecting women worldwide, caused by persistent infection with oncogenic human papillomavirus (HPV) types. While HPV infections usually resolve spontaneously, persistent infections with high-risk HPV types can progress to premalignant glandular or - mostly - squamous intraepithelial lesions, usually classified in cervical intraepithelial neoplasia (CIN). Women with CIN 2 and CIN 3 (i.e. high-grade CIN) typically undergo cervical conisation to remove precan…
Rank108.1
Relationship between human papillomavirus and serum vitamin D levels: a systematic review.
BMC infectious diseases · 2024 · PMID 38216875
BACKGROUND: Human papillomavirus (HPV) is one of the most prevalent sexually transmitted diseases worldwide. The present review was conducted to accumulate evidence on the relationship between cervicovaginal human papillomavirus infection and serum vitamin D status. METHODS: Electronic databases including Web of Science, Embase, Scopus, and PubMed were searched by different combinations of keywords related to "human papillomavirus" and "vitamin D", obtained from Mesh and Emtree with AND, and OR operators without an…
Rank107.8
Prevalence of cervical human papillomavirus infection among women in Ghana: a systematic review and meta-analysis.
BMC public health · 2026 · PMID 42251309
BACKGROUND: Cervical cancer remains a significant public health challenge, particularly in low and middle-income countries, where the burden is disproportionately high. Human papillomavirus (HPV) is the principal cause of cervical cancer, yet evidence on the national prevalence of HPV infection in Ghana remains fragmented and inconsistent across studies. As Ghana prepares to scale up HPV vaccination and expand HPV-based screening, a comprehensive synthesis of HPV prevalence is essential to inform policy and guide p…
Rank107.7
Association between human papillomavirus and preterm delivery: A systematic review and meta-analysis.
Acta obstetricia et gynecologica Scandinavica · 2024 · PMID 39016354
INTRODUCTION: The lifetime prevalence of human papillomavirus infection (HPV) is estimated to be around 80% and it is the most common sexually transmitted infection. Despite being well known for its oncologic relevance, it has been associated with adverse pregnancy outcomes, though available evidence is contradicting. Previous meta-analyses involved articles which based HPV infection on Pap smear results, leading to a significant source of bias. Therefore, we aimed to assess the burden of genetically proven HPV inf…
Rank107.0
Fruits and vegetables and cervical cancer: a systematic review and meta-analysis.
Nutrition and cancer · 2021 · PMID 32156167
We conducted a meta-analysis to examine the association of fruits and vegetables intake with the occurrence of cervical intraepithelial neoplasia (CIN) and invasive cancer. MEDLINE, LILACS, Scopus, Cochrane Library, and Web of Science databases and gray literature on Google Scholar were searched before December 17, 2018. Odds ratio (OR) or relative risk (RR) estimates for the highest vs. the lowest intake of intake and 95% confidence intervals (CI) from the included studies were pooled using fixed and random-effect…
Rank105.9
Characteristic of persistent human papillomavirus infection in women worldwide: a meta-analysis.
PeerJ · 2023 · PMID 38025679
OBJECTIVES: We aimed to estimate the genotype distribution of persistent human papillomavirus (HPV) infection in females worldwide, and provided a scientific basis for the prevention strategies of cervical cancer (CC) and the development of HPV vaccines. METHODS: Both English and Chinese databases were researched from the inception to July 2023. The pooled persistent HPV infection prevalence was calculated using a random effects model. The subgroup analysis was performed to explore the heterogeneity. Publication bi…
Rank105.9
Monogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review.
Genetics in medicine : official journal of the American College of Medical Genetics · 2024 · PMID 37978863
PURPOSE: Persistent human papillomavirus infection (PHPVI) causes cutaneous, anogenital, and mucosal warts. Cutaneous warts include common warts, Treeman syndrome, and epidermodysplasia verruciformis, among others. Although more reports of monogenic predisposition to PHPVI have been published with the development of genomic technologies, genetic testing is rarely incorporated into clinical assessments. To encourage broader molecular testing, we compiled a list of the various monogenic etiologies of PHPVI. METHODS: …
Rank104.9
Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.
The lancet. HIV · 2021 · PMID 34339628
BACKGROUND: Robust age-specific estimates of anal human papillomavirus (HPV) and high-grade squamous intraepithelial lesions (HSIL) in men can inform anal cancer prevention efforts. We aimed to evaluate the age-specific prevalence of anal HPV, HSIL, and their combination, in men, stratified by HIV status and sexuality. METHODS: We did a systematic review for studies on anal HPV infection in men and a pooled analysis of individual-level data from eligible studies across four groups: HIV-positive men who have sex wit…
Rank104.4
The Prevalence of HPV in Oral Cavity Squamous Cell Carcinoma.
Viruses · 2023 · PMID 36851665
Human papillomavirus (HPV) is an important risk factor in a subset of head and neck squamous cell carcinomas (HNSCC), but the association with oral cavity squamous cell carcinomas (OCSCC) remains controversial. This study aimed to identify the prevalence of HPV infection in OCSCC. A systematic search on PubMed and EMBASE was performed, including articles assessing the prevalence of HPV-positive (HPV+) OCSCC published from January 2017 to December 2022. OCSCC was considered HPV+ by the detection of HPV DNA, HPV RNA,…
Rank103.8
HPV and lung cancer: A systematic review and meta-analysis.
Cancer reports (Hoboken, N.J.) · 2021 · PMID 33624444
BACKGROUND: Lung cancer has emerged as a global public health problem and is the most common cause of cancer deaths by absolute cases globally. Besides tobacco, smoke infectious diseases such as human papillomavirus (HPV) might be involved in the pathogenesis of lung cancer. However, data are inconsistent due to differences in study design and HPV detection methods. AIM: A systematic meta-analysis was performed to examine the presence of HPV-infection with lung cancer. METHODS AND RESULTS: All studies in all langua…
Rank103.5
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
BMJ (Clinical research ed.) · 2022 · PMID 35922074
OBJECTIVE: To explore the efficacy of human papillomavirus (HPV) vaccination on the risk of HPV infection and recurrent diseases related to HPV infection in individuals undergoing local surgical treatment. DESIGN: Systematic review and meta-analysis DATA SOURCES: PubMed (Medline), Scopus, Cochrane, Web of Science, and ClinicalTrials.gov were screened from inception to 31 March 2021. REVIEW METHODS: Studies reporting on the risk of HPV infection and recurrence of disease related to HPV infection after local surgical…
Rank103.0
Cytology versus HPV testing for cervical cancer screening in the general population.
The Cochrane database of systematic reviews · 2017 · PMID 28796882
BACKGROUND: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test. OBJECTIVES: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cance…
Rank102.8
Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis.
The Lancet. Global health · 2023 · PMID 37591583
BACKGROUND: The epidemiology of human papillomavirus (HPV) in women has been well documented. Less is known about the epidemiology of HPV in men. We aim to provide updated global and regional pooled overall, type-specific, and age-specific prevalence estimates of genital HPV infection in men. METHODS: We conducted a systematic review and meta-analysis to assess the prevalence of genital HPV infection in the general male population. We searched Embase, Ovid MEDLINE, and the Global Index Medicus for studies published…
Rank101.5
Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies.
BMC medicine · 2023 · PMID 37501128
BACKGROUND: Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect against malignant transformation. Randomised evidence is limited and the validity of observational studies describing these associations remains unclear. METHODS: In this umbrella review, we searched electronic databases to identify meta-analyses of observational studies that evaluated risk or protec…
Rank101.1
Human papillomavirus infection and female infertility: a systematic review and meta-analysis.
Reproductive biomedicine online · 2020 · PMID 31987733
There is increasing evidence that human papillomavirus (HPV) infection affects reproductive health and fertility, although its impact on female fertility has not been thoroughly studied. MEDLINE, Embase, CENTRAL, Web of Science, CNKI, Wanfang, VIP and ClinicalTrials.gov databases were systematically searched for relevant articles. A meta-analysis was conducted of 11 studies including 15,450 female subjects that compared HPV prevalence between the infertile and general population, and evaluated the association betwe…
Rank100.7
Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial.
Scientific reports · 2026 · PMID 42215629
Alcohol consumption is recognized as a risk factor for oropharyngeal cancer. However, its role in oral human papillomavirus (HPV) infection among people living with HIV (PLWH) remains unclear. This cross-sectional study analyzed baseline data from 699 men living with HIV (MLWH) enrolled in the multicenter ULACNet-201 trial (NCT04255849) to assess oral HPV infection by drinking behavior, examine the association between alcohol consumption and HPV infection, exploring smoking as a potential effect modifier. Oral garg…
Rank100.6
Human papillomavirus and risk of prostate cancer: a systematic review and meta-analysis.
The aging male : the official journal of the International Society for the Study of the Aging Male · 2020 · PMID 29571270
Background: There is growing evidence showing a putative association between high-risk human papillomavirus (HR-HPV) infection and an increased risk of PCa.Objective: The aim of the current meta-analysis was to evaluate the association between HPV infection and PCa risk.Methods: This analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. We included all studies on HPV DNA or antibodies detected in biopsy tissues or sera. Available data were extracted f…
Rank100.0
Human Papilloma Virus Infection and Sinonasal Inverted Papilloma Recurrence: A Meta-Analysis.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025 · PMID 39739414
OBJECTIVE: Prior studies have been contradictory on the role of human papillomavirus (HPV) infection in sinonasal inverted papilloma (SNIP) recurrence. This systematic review and meta-analysis was performed to further evaluate this potential association. DATA SOURCES: PubMed, Embase, and Scopus electronic databases. REVIEW METHODS: Case-control studies reporting SNIP recurrence data and HPV status identified by polymerase chain reaction (PCR) and in-situ hybridization (ISH). Meta-analysis was performed to determine…
Rank100.0
Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review.
Human vaccines & immunotherapeutics · 2025 · PMID 40485552
Cervical cancer is a preventable disease for which vaccines are available to provide long-term protection against human papillomavirus (HPV) infection. This systematic literature review (SLR) was performed to summarize the efficacy, effectiveness, impact, duration of protection, and safety profile of four licensed HPV vaccines against infection, precursor lesions, and cervical cancer. Data was extracted from published reports. The search resulted in 1,136 studies, of which 54 were selected for this review. A substa…
Rank100.0
Human Papillomavirus-Attributable Head and Neck Cancers in India-A Systematic Review and Meta-Analysis.
JCO global oncology · 2024 · PMID 38513185
PURPOSE: Head and neck cancer accounts for about one third of the global burden in India. Mucosal high-risk human papillomavirus (HPV) has been hypothesized as a contributory risk factor for head and neck cancer (HNC) but its prevalence in Indian patients is not well established. Therefore, this systematic review and meta-analysis aimed to estimate the prevalence of HPV in HNC in India and their attributable fraction by considering the biomarkers of carcinogenesis, p16, and HPV E6/E7 mRNA. METHODS: A systematic lit…
Rank100.0
Impact of health education intervention on knowledge and attitude towards HPV vaccination in Africa: A systematic review.
Vaccine · 2026 · PMID 42468223
BACKGROUND: Human Papillomavirus (HPV) is a leading cause of cervical cancer, with sub-Saharan Africa experiencing the highest prevalence and mortality. Although an effective vaccine exists, uptake across Africa remains low due to poor knowledge, misinformation, logistical barriers, and vaccine hesitancy. This review aimed to synthesize evidence on the impact of health education interventions on HPV vaccination knowledge and attitudes in Africa. METHODS: This systematic review was conducted following Aromataris & P…
Rank100.0
Human papillomavirus-associated nasopharyngeal carcinoma: A systematic review and meta-analysis.
Oral oncology · 2024 · PMID 39383626
OBJECTIVE: Human papillomavirus (HPV) is known to affect head and neck sites beyond the oropharynx, including the nasopharynx. Unlike HPV-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC), HPV-associated nasopharyngeal carcinoma (HPV+NPC) is not well characterized and the true prevalence in non-endemic regions is poorly described. Here, we sought to obtain a global point prevalence of HPV in NPC, stratified by geographic region. DATA SOURCES: EMBASE, OVID Medline, and Web of Science were systematically s…
Rank99.9
High Risk of New HPV Infection Acquisition Among Unvaccinated Young Men.
The Journal of infectious diseases · 2024 · PMID 38012959
BACKGROUND: International data on anogenital HPV infection incidence among men are limited. METHODS: Incidence of incident-persistent (IP) anogenital HPV infections was evaluated among 295 men who have sex with men (MSM) and 1576 heterosexual men (HM) aged 16-27 years in the placebo arm of a global, multicenter 4-valent (4v) HPV vaccine trial. We estimated IP incidence (penile/scrotal, perineal/perianal, anal) for 4vHPV and 9-valent (9v) HPV vaccine types and cumulative IP incidence over 36 months. RESULTS: IP infe…
Most Effective Evidence Supported Treatments73 records
Rank113.0
2024 recommendations for the therapeutic management of anogenital warts.
Annales de dermatologie et de venereologie · 2026 · PMID 42235479
INTRODUCTION: Anogenital warts (AGW) are benign epithelial skin lesions caused mainly by the human papillomavirus (HPV, types 6 and 11) but are sometimes associated with other oncogenic HPV types. They have a high rate of post-treatment recurrence. There are many guidelines, but they do not prioritise treatments. Therapeutics are classified as either self-administered or clinician applied. The aim of this study was to propose recommendations for the management of AGW. METHOD: These recommendations were based on a s…
Rank110.0
SEOM-TTCC clinical guidelines for the treatment of head and neck cancer (2025).
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026 · PMID 41843267
Squamous cell carcinoma of the lip, oral cavity, oropharynx, hypopharynx, and larynx comprises the ninth most common cancer in Spain. While alcohol and tobacco use have long been the primary etiological factors, the role of human papillomavirus (HPV) in oropharyngeal cancer is increasing. Diagnoses and relapses should always be discussed by an expert multidisciplinary team. For localized stages, surgery or radiotherapy should be used as single-modality treatments, while locoregional stages require combined modality…
Rank108.7
Human papillomavirus (HPV) vaccination in women with conisation.
The Cochrane database of systematic reviews · 2025 · PMID 40919695
RATIONALE: Cervical cancer is the fourth most common cancer affecting women worldwide, caused by persistent infection with oncogenic human papillomavirus (HPV) types. While HPV infections usually resolve spontaneously, persistent infections with high-risk HPV types can progress to premalignant glandular or - mostly - squamous intraepithelial lesions, usually classified in cervical intraepithelial neoplasia (CIN). Women with CIN 2 and CIN 3 (i.e. high-grade CIN) typically undergo cervical conisation to remove precan…
Rank107.8
HPV circulating tumor DNA as a potential prognostic and predictive biomarker in head and neck squamous cell carcinoma: a systematic review.
Oral oncology · 2026 · PMID 42641201
PURPOSE: Human papillomavirus circulating tumor DNA (HPVctDNA) has emerged as a promising prognostic biomarker in HPV-related head and neck squamous cell carcinoma (HNSCC). This systematic review aimed to synthesize current evidence on the diagnostic accuracy and prognostic value of HPVctDNA in HNSCC management. MATERIAL/METHODS: We systematically reviewed a PubMed-indexed database of studies published between January 2012 and September 2025. Eligible studies were assessed for design, primary tumor site and stage, …
Rank107.1
Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for cervical squamous intraepithelial lesion: a systematic review and meta-analysis.
Lasers in medical science · 2026 · PMID 42470528
To evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for cervical squamous intraepithelial lesion (SIL). We systematically searched PubMed and other databases to compare the effectiveness of 5-ALA PDT with observation, ablation, and conization. Outcomes included overall response rate (ORR), complete remission (CR) rate, HPV clearance rate, and other relevant endpoints. Single-arm analyses were additionally performed by lesion grade. A total of 3,354 patients were included ac…
Rank107.1
Subsequent-line Systemic Therapy for Metastatic or Recurrent Penile Cancer: A Systematic Review of Efficacy, Toxicity, and Outcomes.
European urology focus · 2026 · PMID 41519649
BACKGROUND AND OBJECTIVE: Treatment options for metastatic or recurrent penile squamous cell carcinoma (PSCC) progressing after first-line platinum-based chemotherapy are limited, and no standard subsequent-line systemic therapy exists. We systematically reviewed the efficacy, safety, and survival outcomes of second- and later-line systemic treatments in this setting. METHODS: A systematic review, compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, was performed across …
Rank106.6
Effect of Smoking in Oropharyngeal Cancer Treated With TORS: Systematic Review and Meta-Analysis.
The Laryngoscope · 2026 · PMID 42103481
OBJECTIVE: While smoking has been implicated as a risk factor for recurrence in HPV-associated oropharyngeal squamous cell cancer (OPSCC) treated with definitive chemoradiation, its prognostic impact on surgically treated OPSCC is less clear. DATA SOURCES: MEDLINE, Embase, CENTRAL, and Scopus. REVIEW METHODS: Articles describing patients with HPV-associated OPSCC treated with transoral robotic surgery (TORS), which reported oncologic outcomes by smoking history, were included. RESULTS: 2079 patients were included a…
Rank106.4
De-Escalation Treatment Strategies in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An Umbrella Review of Systematic Reviews and Meta-Analyses.
Head & neck · 2026 · PMID 42230323
BACKGROUND: De-escalation strategies for human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) aim to reduce late morbidity while preserving cure rates, but evidence syntheses provide inconsistent conclusions and may be affected by overlap of primary studies. METHODS: We performed an umbrella review of systematic reviews (SRs) and meta-analyses (MAs) evaluating de-escalation approaches versus standard-of-care therapy in HPV-positive (or p16-positive) OPSCC. MEDLINE (PubMed), Embase, and …
Rank106.0
Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis.
Medicine · 2026 · PMID 42363527
BACKGROUND: Despite the general advantages of neoadjuvant immunotherapy for locally advanced head and neck squamous cell carcinoma (LAHNSCC), many patients do not achieve successful clinical outcomes. Hitherto, there has been a lack of biomarkers to predict the effect of neoadjuvant immunotherapy in LAHNSCC. METHODS: We systematically searched PubMed, Embase, Web of Science, and Cochrane databases until June 2024 for studies related to neoadjuvant immunotherapy for LAHNSCC. We calculated the pathological response r…
Rank106.0
A meta-analysis of photodynamic therapy in the treatment of cervical intraepithelial neoplasia: Based on randomized controlled trials.
Photodiagnosis and photodynamic therapy · 2026 · PMID 41740824
OBJECTIVE: To systematically evaluate the efficacy and safety of photodynamic therapy (PDT) for HPV-infected cervical intraepithelial neoplasia (CIN) based on randomized controlled trials (RCTs). METHODS: A systematic search was performed across PubMed, EMBASE, Web of Science, and the Cochrane Library from 2000 to 2025, targeting RCTs that compared PDT with standard conization methods or placebo. The primary outcomes assessed included histopathological response, human papillomavirus (HPV) clearance, and the rate of…
Rank105.8
Transoral robotic surgery versus definitive (Chemo)radiotherapy in early HPV-positive oropharyngeal cancer: A systematic review and meta-analysis of oncologic outcomes.
Oral oncology · 2026 · PMID 41806530
INTRODUCTION: Although individual studies suggest similar oncologic outcomes between transoral robotic surgery (TORS) and definitive (chemo)radiotherapy (RT/CRT) for early-stage human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC), oncologic and functional outcomes have not been systematically synthesized. OBJECTIVE: To compare oncologic and functional outcomes of a primary surgery-based strategy versus a primary definitive RT/CRT strategy in early-stage HPV-OPSCC. METHODS: PubMed, Embase…
Rank105.1
Surgical and Voice Outcomes of Office-Based Recurrent Respiratory Papillomatosis Surgery: A Systematic Review.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026 · PMID 41848235
OBJECTIVE: To investigate the surgical and voice outcomes associated with office-based laryngeal surgery for the treatment of recurrent respiratory papillomatosis (RRP). DATA SOURCES: PubMed, Google Scholar, and Cochrane databases. REVIEW METHODS: Two independent investigators search databases for studies reporting surgical or voice quality outcomes of patients treated with office-based surgery for RRP according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Primary o…
Rank104.5
Marjolin's Ulcer in Patients With Anogenital Lichen Planus: A Systematic Review.
Journal of cutaneous medicine and surgery · 2026 · PMID 41169103
Anogenital lichen planus (ALP) is a chronic inflammatory condition associated with significant morbidity and a potential risk of cutaneous squamous cell carcinoma (cSCC), specifically Marjolin ulcer (MU), a rare, but aggressive, life-threatening complication. This systematic review aimed to describe the clinical characteristics of patients developing MU within ALP and its treatment outcomes. MEDLINE and Embase (inception-November 2024) were searched, identifying studies reporting MU or squamous dysplasia arising wi…
Rank102.0
Efficacy and safety of superficial radiotherapy in the treatment of cutaneous warts: A meta-analysis.
The Journal of international medical research · 2026 · PMID 42333510
ObjectiveTo systematically evaluate clinical evidence concerning the efficacy and safety of superficial radiotherapy in the treatment of cutaneous warts.MethodsEight major international clinical literature databases were queried according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for superficial radiotherapy studies published prior to 9 August 2025. Randomized controlled trials, prospective/retrospective controlled studies, and case series with sample sizes ≥10 we…
Rank101.5
[Efficacy and safety of hexaminolevulinate photodynamic therapy for CIN2].
Zhonghua fu chan ke za zhi · 2026 · PMID 42706058
Objective: To evaluate the efficacy and safety of hexaminolevulinate photodynamic therapy (HAL-PDT) for the treatment of cervical intraepithelial neoplasia 2 (CIN2). Methods: Data of this study were derived from an international multicenter, randomized, double-blind, placebo-controlled phase Ⅲ clinical trial (the APRICITY study) conducted between October 2020 and July 2023, with medical records obtained from 61 medical centers across 7 countries. A subgroup analysis was performed in patients with histologically con…
Rank100.0
Efficacy of topical treatments for high-risk human papillomavirus in preventing CIN II+ lesions: a systematic review.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026 · PMID 41951281
OBJECTIVE: This study aimed to systematically review the literature regarding topical therapies for reducing the risk of cervical intra-epithelial neoplasia (CIN) grade 2 or higher (CIN II+) lesions among women with high-risk human papillomavirus (HPV) infection and histologically confirmed CIN I or either no cervical lesions. METHODS: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered the protocol in PROSPERO (CRD4202…
Rank100.0
Rapid Systematic Review-Informed Multidisciplinary Expert Consensus on the Management of HPV-Positive Women with Low-Grade Cervical Lesions and the Role of a Coriolus versicolor-Based Vaginal Treatment.
Medicina (Kaunas, Lithuania) · 2026 · PMID 42512825
Background and Objectives: Persistent human papillomavirus (HPV) infection is associated with the development of cervical intraepithelial neoplasia and cervical cancer. In women with low-grade cervical lesions, a conservative management approach is commonly recommended. However, a subset of patients may experience lesion progression, which can also be accompanied by psychological distress. Adjuvant therapies during the surveillance period have gained increasing clinical interest. This consensus aims to provide mult…
Rank100.0
Advancements in immunotherapy for oropharyngeal cancer: Current landscape and future prospects.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026 · PMID 40827652
Oropharyngeal cancer (OPC), affecting the tonsils, base of the tongue, and soft palate, has witnessed a notable increase in incidence, particularly among cases linked to human papillomavirus (HPV) infection. This epidemiological shift has led to changes in treatment strategies, with immunotherapy emerging as a promising alternative to conventional modalities such as surgery, radiation, and chemotherapy, which are often associated with significant toxicity. This systematic review aims to evaluate the current landsca…
Rank100.0
Oncologic, functional, and economic outcomes of transoral robotic surgery for HPV-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of pathology and treatment strategies.
Journal of robotic surgery · 2026 · PMID 42162526
The incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has increased substantially. Transoral robotic surgery (TORS) provides detailed pathological assessment that may support risk-adapted treatment strategies; however, integrated evidence on oncologic, functional, and economic outcomes remains limited. To systematically evaluate oncologic, functional, and economic outcomes of TORS-based treatment strategies in patients with HPV-positive OPSCC. A systematic review and met…
Rank100.0
HPV vaccination efficacy in primary and tertiary prevention of vulvar and vaginal HPV-related high grade dysplasia and cancers: A systematic review.
Human vaccines & immunotherapeutics · 2025 · PMID 41158101
The impact of HPV vaccination on cervical cancer and condylomas is well-established, but its effectiveness against high grade vulvar and vaginal lesions (VIN/VaIN) and related cancers remains less clear due to their rarity. This systematic review assessed the efficacy of quadrivalent (qHPV) and 9-valent (9vHPV) vaccines in both primary and tertiary prevention of these conditions. Eleven studies met the inclusion criteria. qHPV showed 100% efficacy against HPV16/18-related VIN/VaIN and cancers in per-protocol popula…
Rank100.0
Impact of male genital tract infections on semen quality: a systematic review and meta-analysis.
Fertility and sterility · 2026 · PMID 41825760
Male genitourinary (GU) infections have been proposed to adversely affect semen quality and reproductive outcomes; however, existing evidence remains heterogeneous. This systematic review and meta-analysis evaluated the association between GU infections and semen parameters, reproductive outcomes, and assisted reproductive technology (ART) outcomes using control-comparator studies identified through PubMed, Web of Science, and Embase. Studies compared men with documented GU infections with noninfected controls and …
Rank100.0
Intralesional human papillomavirus vaccination for cutaneous verrucae: a systematic review and meta-analysis of therapeutic efficacy.
The Journal of dermatological treatment · 2026 · PMID 42370553
OBJECTIVES: To evaluate the efficacy of intralesional human papillomavirus (HPV) vaccination in the management of cutaneous warts. METHODS: A comprehensive search of PubMed, MEDLINE, Embase, Scopus, and ClinicalTrials.gov was conducted in accordance with a registered PROSPERO protocol (CRD420251170324). Chronic or persistent warts were defined as lesions lasting more than six months or showing inadequate response to conventional therapies. The primary outcome was complete wart clearance, and pooled risk ratios (RRs…
Rank100.0
Cervical cancer screening policy inequality worldwide: a systematic review of disparities in access and implementation.
Journal of translational medicine · 2026 · PMID 42288897
BACKGROUND: The rising global burden of cervical cancer and persistent inequalities in screening access underscore the need to strengthen implementation. Therefore, we compiled the cervical cancer screening guidelines from different countries/regions and evaluated their implementation status and coverage situation. METHODS: In this study, we conducted comprehensive search of the PubMed, Embase and Web of Science databases (from their establishment to February 1, 2025), websites and the World Health Organization (WH…
Rank100.0
Hidradenitis suppurativa-associated squamous cell carcinoma: a systematic review of clinical, molecular, and risk factor insights.
Italian journal of dermatology and venereology · 2026 · PMID 42206557
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the pilosebaceous unit that can rarely harbor squamous cell carcinoma (SCC). Despite its clinical relevance, comprehensive characterization of HS-SCC - including risk factors, histological and molecular features, and outcomes - remains limited. METHODS: A systematic review of the literature was performed to identify all published cases of HS-associated SCC. Data on demographics, HS features, tumor characteristics, human papillomavirus (H…
Rank100.0
Immunological and antitumor responses to HPV-targeted therapeutic vaccines in preclinical models of head and neck cancer: a systematic review.
Cancer metastasis reviews · 2026 · PMID 42550292
Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasingly prevalent and accounts for 22-70% of HNSCCs depending on the region. Although prophylactic HPV vaccines were approved in the early 2000s to prevent HPV infection and oncogenesis, they are ineffective against established HPV infections and related cancers. The standard of care for these HPV-associated oropharyngeal cancers combines radiotherapy, surgery, and chemotherapy. However, these treatments can result in signif…
New Research Last 24 Months135 records
Rank108.4
The impact of HIV coinfection on mpox patients: a systematic review and meta-analysis.
Emerging microbes & infections · 2026 · PMID 42461714
A substantial proportion of mpox cases occur in people with HIV, but how HIV coinfection and immune status affect clinical outcomes remains unclear. We systematically searched major databases up to March 2025 for observational studies comparing mpox patients with and without HIV coinfection. Pooled effect sizes were calculated using random-effects models. Risk ratios (RRs) or standardized mean differences (SMDs) with 95% confidence intervals were used for dichotomous or continuous outcomes. Post hoc subgroup analys…
Rank107.8
Prevalence of cervical human papillomavirus infection among women in Ghana: a systematic review and meta-analysis.
BMC public health · 2026 · PMID 42251309
BACKGROUND: Cervical cancer remains a significant public health challenge, particularly in low and middle-income countries, where the burden is disproportionately high. Human papillomavirus (HPV) is the principal cause of cervical cancer, yet evidence on the national prevalence of HPV infection in Ghana remains fragmented and inconsistent across studies. As Ghana prepares to scale up HPV vaccination and expand HPV-based screening, a comprehensive synthesis of HPV prevalence is essential to inform policy and guide p…
Rank106.0
Immunological consequences of mesenchymal stem cell therapy in HPV-driven cervical cancer: A systematic review and stratification framework.
Critical reviews in oncology/hematology · 2026 · PMID 42660395
Over 660,000 women develop cervical cancer annually, caused by persistent infection with high-risk human papillomavirus (HPV). Published studies of mesenchymal stem/stromal cells (MSCs) as immunomodulatory agents are contradictory, with some reporting tumor suppression and others tumor promotion. The mechanism of these paradoxes has not been systematically investigated. This review aims to assess MSC-mediated immune evasion in HPV-related cervical cancer, quantify HPV stratification failure in the literature, and f…
Rank102.2
Diagnostic accuracy of HPV DNA in oral gargle and rinse samples for Head and neck squamous cell carcinoma: A systematic review and meta-analysis.
The Japanese dental science review · 2026 · PMID 42211773
BACKGROUND: Early detection of head and neck squamous cell carcinoma (HNSCC) remains challenging because tissue biopsy is invasive and unsuitable for repeated monitoring or large-scale screening. This study systematically evaluated the diagnostic accuracy of human papillomavirus (HPV) DNA detection in oral gargle and rinse samples for HNSCC. METHODS: This meta-analysis followed PRISMA guidelines and included 10 studies with 1315 participants. Pooled sensitivity, specificity, summary receiver operating characteristi…
Rank100.7
Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial.
Scientific reports · 2026 · PMID 42215629
Alcohol consumption is recognized as a risk factor for oropharyngeal cancer. However, its role in oral human papillomavirus (HPV) infection among people living with HIV (PLWH) remains unclear. This cross-sectional study analyzed baseline data from 699 men living with HIV (MLWH) enrolled in the multicenter ULACNet-201 trial (NCT04255849) to assess oral HPV infection by drinking behavior, examine the association between alcohol consumption and HPV infection, exploring smoking as a potential effect modifier. Oral garg…
Rank100.0
Intralesional human papillomavirus vaccination for cutaneous verrucae: a systematic review and meta-analysis of therapeutic efficacy.
The Journal of dermatological treatment · 2026 · PMID 42370553
OBJECTIVES: To evaluate the efficacy of intralesional human papillomavirus (HPV) vaccination in the management of cutaneous warts. METHODS: A comprehensive search of PubMed, MEDLINE, Embase, Scopus, and ClinicalTrials.gov was conducted in accordance with a registered PROSPERO protocol (CRD420251170324). Chronic or persistent warts were defined as lesions lasting more than six months or showing inadequate response to conventional therapies. The primary outcome was complete wart clearance, and pooled risk ratios (RRs…
Rank100.0
The population impact of human papillomavirus vaccination on cancer and pre-cancer outcomes: An umbrella review of meta-analyses.
Human vaccines & immunotherapeutics · 2026 · PMID 42409728
Despite widespread HPV vaccination, a comprehensive synthesis across populations and cancer outcomes is lacking. This umbrella review evaluates HPV vaccination's population impact on infection, precancerous lesions, and invasive cancers. We searched five databases for meta-analyses reporting prophylactic HPV vaccine outcomes up to Jan 2026. Two reviewers performed selection, data extraction, AMSTAR-2, and GRADE. From 34 meta-analyses, RCTs in HPV-naïve women showed 99% efficacy (95% CI: 98-99%) against HPV16/18 inf…
Rank100.0
Population-level impact of HPV vaccination: a global systematic review of ecological, cross-sectional, and cohort studies.
Expert review of vaccines · 2026 · PMID 42053091
BACKGROUND: Human papillomavirus (HPV) causes approximately 4.5% of cancers globally, with the highest burden in low- and middle-income countries (LMICs). Since their introduction in 2006, HPV vaccination programs have led to substantial declines in HPV-related outcomes, although impact varies across settings. RESEARCH DESIGN AND METHODS: We conducted a systematic review to evaluate the population-level impact of HPV vaccination on HPV infection, cervical intraepithelial neoplasia grade 2 or higher (CIN2+), genital…
Rank100.0
Strategies implemented to increase HPV vaccine uptake and confidence among men who have sex with men and transgender people: A systematic review.
Human vaccines & immunotherapeutics · 2026 · PMID 42216453
Men who have sex with men (MSM) and transgender persons are disproportionately affected by HPV-related disease. The HPV vaccine effectively prevents infection, but vaccine uptake remains suboptimal in this group. Thus, this systematic review aimed to synthesize the literature on interventions and strategies implemented to increase HPV vaccine confidence and uptake among MSM and transgender persons. Six databases were searched in May 2025. We assessed risk of bias and extracted and descriptively summarized key data …
Rank100.0
Impact of health education intervention on knowledge and attitude towards HPV vaccination in Africa: A systematic review.
Vaccine · 2026 · PMID 42468223
BACKGROUND: Human Papillomavirus (HPV) is a leading cause of cervical cancer, with sub-Saharan Africa experiencing the highest prevalence and mortality. Although an effective vaccine exists, uptake across Africa remains low due to poor knowledge, misinformation, logistical barriers, and vaccine hesitancy. This review aimed to synthesize evidence on the impact of health education interventions on HPV vaccination knowledge and attitudes in Africa. METHODS: This systematic review was conducted following Aromataris & P…
Rank96.4
Immunogenicity and Safety of 2 Versus 3 Doses of 9-Valent Vaccine Against Human Papillomavirus in Women With Human Immunodeficiency Virus: The Papillon Randomized Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 40356381
BACKGROUND: The World Health Organization recommends 2 doses of human papillomavirus (HPV) vaccine for adults without human immunodeficiency virus (HIV) but 3 doses in persons with HIV. There are no immunogenicity data on the 2-dose schedule in women with HIV (WWH). METHODS: This was a prospective study comparing 2 doses (months 0 and 6) versus 3 (months 0, 2, and 6) doses of 9-valent vaccine (Gardasil 9, Merck Sharp & Dohme) in WWH (15-40 years), on antiretrovirals with HIV RNA <400 copies/mL, enrolled during 2018…
Rank96.0
Effectiveness of Electrocautery, Topical Cidofovir, and Topical Sinecatechins for the Treatment of Anal High-Grade Squamous Intraepithelial Lesions in Persons With HIV: An Open-Label, Randomized Controlled Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40036375
BACKGROUND: Doubts remain about the best treatment for managing premalignant lesions (high-grade squamous intraepithelial lesions [HSIL]) associated with anal cancer. METHODS: The TREATAIN trial was an open-label, randomized study conducted at Hospital Vall d'Hebron (Spain). Persons with human immunodeficiency virus and anal HSIL were randomly assigned 1:1:1 to receive treatment with electrocautery, topical cidofovir 1% ointment, or topical sinecatechins 10%. The primary outcome was histological resolution of HSIL.…
Rank95.7
Effect of human papillomavirus education on human papillomavirus knowledge and gynecologic cancer awareness among women aged 18-49: a randomized controlled study.
Revista da Associacao Medica Brasileira (1992) · 2026 · PMID 42585526
OBJECTIVE: Human papillomavirus is a major cause of cervical and other human papillomavirus-related cancers, and education is essential for prevention. The aim of this study was to evaluate the effect of a structured human papillomavirus education program on women's human papillomavirus knowledge, health beliefs, and gynecologic cancer awareness. METHODS: A randomized controlled study was conducted with 68 women assigned to intervention and control groups. The intervention included four weekly educational sessions,…
Rank95.6
Pilot Randomized Controlled Trial of an Intervention to Promote HPV Uptake Among Young Women Who Attend Subsidized Clinics.
Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2024 · PMID 39030937
OBJECTIVE: To evaluate the preliminary efficacy, acceptability, and feasibility of Step Up to Prevention, a technology-enhanced intervention to promote human papillomavirus (HPV) vaccination uptake among young minority and low-income women. DESIGN: A pilot randomized controlled trial. SETTING: Two federally supported outpatient clinics in a large city in the northeastern United States. PARTICIPANTS: Women who were 18 to 26 years of age (N = 60). METHODS: We randomized participants into four groups: computer informa…
Rank94.6
Long-term safety of human papillomavirus vaccination in relation to early pregnancy outcomes: registry-based follow-up of a community-randomized trial.
European journal of public health · 2026 · PMID 42586610
Despite the demonstrated safety of human papillomavirus vaccines, concerns have arisen regarding potential associations of human papillomavirus vaccination on reproductive health. The objective of this registry-based study was to compare overtime association of vaccination and early pregnancy outcomes. Twenty thousand four hundred twenty-six women born in 1992-1995, who participated in a Finnish community-randomized human papillomavirus vaccination trial, and age- and community-aligned unvaccinated controls born in…
Rank92.0
Clinician Perceptions of the Impact of Switching HPV Vaccine Initiation to 9-10 Years.
Pediatrics · 2026 · PMID 41942137
BACKGROUND AND OBJECTIVES: Although HPV vaccine initiation as early as aged 9 years has been recommended, most clinicians initiate at ages 11 to 12 years. We assessed clinician-reported impact of early initiation on parental responses and vaccine discussions. METHODS: As part of an ongoing cluster randomized pragmatic trial across 31 Colorado and California pediatric practices, we allocated practices to switch HPV vaccine initiation to ages 9 to 10 years or to enhanced usual care (initiation at ages 11 to 12 years)…
Rank92.0
Anal Human Papillomavirus Infection Progression to Disease Among Men Who Have Sex With Men.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41162330
BACKGROUND: Critical gaps exist in our understanding of the progression from anal human papillomavirus (HPV) infection to same-type HPV-associated anal disease in human immunodeficiency virus (HIV)-negative men who have sex with men (MSM). We conducted a post hoc analysis of a phase 3 randomized 4-valent HPV vaccine trial (NCT00090285) to assess the natural progression of anal HPV infections to associated anal lesions among MSM. PARTICIPANTS: A total of 602 HIV-negative MSM aged 16-27 years. METHODS: HIV-negative M…
Rank87.0
FIGO/IGCS statement on the efficacy of topical treatments for high-risk human papillomavirus in preventing CIN 3+ lesions.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026 · PMID 42677467
Cervical cancer is caused by persistent high-risk human papillomavirus (HR-HPV) infection and remains a major global health burden despite available preventive strategies. Most HR-HPV infections and associated low-grade squamous intraepithelial lesions (LSIL) regress spontaneously, yet increasing commercial promotion of topical therapies targeting HPV clearance has emerged in clinical practice. This FIGO/International Gynecologic Cancer Society (IGCS) Position Statement critically appraises the available evidence o…
Rank87.0
[Anal cancer screening: who, how, and why?].
Virologie (Montrouge, France) · 2026 · PMID 41789701
Although anal cancer remains rare in the general population, it is becoming more prevalent, particularly in high-income countries such as France, where the incidence rate is among the highest in the world. Over 90 % of anal cancers are caused by high-risk human papillomavirus (HR-HPV), particularly HPV16. Although two-thirds of cases occur in women, certain groups are at a higher risk, including men who have sex with men (MSM) living with HIV, women living with HIV, women with a history of high-grade vulvar lesions…
Rank85.0
Assessment of atypical glandular cell interpretation in Pap tests using the Hologic Genius Digital Diagnostics System.
Cancer cytopathology · 2026 · PMID 42622122
Atypical glandular cells (AGC) are a diagnostic challenge. The aim of this study was to evaluate the efficacy and diagnostic performance of AGC detection on the Hologic Genius Digital Diagnostics System (HGDDS). A retrospective analysis of 451 ThinPrep Pap cases was conducted, including 207 cases of AGC, 27 cases of high-grade squamous intraepithelial lesion (HSIL), 25 cases of low-grade squamous intraepithelial lesion (LSIL), and 192 benign cases. All AGC cases had follow-up histologic diagnoses, with 66 cases sub…
Rank82.9
HPV vaccine awareness and uptake among women attending cervical screening in health-resource-limited areas of China: A multicenter cross-sectional study.
Human vaccines & immunotherapeutics · 2026 · PMID 41830505
Evidence shows HPV vaccination reduces infection, precancer and cervical cancer, yet coverage in health-resource-limited of China remains uncertain. We assessed awareness, uptake and correlates among women attending cervical screening, and examined associations with screening outcomes. We conducted a cross-sectional study in eight county sites in 2023-2024 among women aged 35-64 y. A standardized questionnaire captured sociodemographic factors, awareness and vaccination. Cervical samples were tested for hrHPV. Outc…
Rank80.8
The prognostic value of different HPV infection statuses in cervical cancer.
Scientific reports · 2026 · PMID 42289582
To compare oncological outcomes between HPV-positive and HPV-negative cervical cancer patients in a large Chinese multicenter cohort. This retrospective study included cervical squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. Propensity score matching (PSM, 2:1) was used to balance baseline characteristics. Kaplan-Meier method and Cox proportional hazards regression were applied to compare 5-year overall survival (OS) and disease-free survival (DFS). The proportional hazards assumption was test…
Rank72.0
Monitoring the safety of the adjuvanted human papillomavirus vaccine HPV-16/18-AS04 in association with pregnancy and potential immune-related diseases in China: A retrospective observational cohort study.
Human vaccines & immunotherapeutics · 2026 · PMID 42348585
Human papillomavirus (HPV) infection causes cervical cancer. The objective of the study is to monitor AS04-adjuvanted HPV-16/18 vaccine (Cervarix, GSK) safety in a real-world setting in China, using electronic health records from the Yinzhou Regional Health Information Platform (YRHIP). This retrospective observational cohort study included all permanent residents (males and females) aged 9-45 y with ≥12 months continuous YRHIP registration between 1 January 2010 and 31 December 2020. The study analyzed demographic…
Rank70.0
Genetically Proxied Inhibition of Cholesterol-Lowering Drug Targets and Survival in HPV-Positive and Non-HPV-Driven Head and Neck Cancer: A Multicentre MR Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026 · PMID 42390334
BACKGROUND: Cholesterol pathways may influence head and neck squamous cell carcinoma (HNSCC) progression, but evidence on prognosis is inconsistent. We used Mendelian randomization (MR) to test whether genetically proxied inhibition of major low-density lipoprotein cholesterol (LDL-C)-lowering drug targets and circulating lipid traits affects overall survival (OS) in HPV-positive and non-HPV-driven HNSCCs. METHODS: We proxied lifelong LDL-C lowering using 55 cis-acting single-nucleotide polymorphisms in HMGCR, NPC1…
Rank69.8
Association of HLA-G alleles with type-specific HPV seropositivity and seropersistence in unvaccinated women: A prospective cohort study.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2026 · PMID 42674163
INTRODUCTION: The human leukocyte antigen G (HLA-G) allele repertoire is crucial for cell-mediated immune responses. While HLA-G's role in human papillomavirus (HPV) infection is increasingly studied, research on HLA-G and humoral immunity remains limited. This study aimed to establish whether HLA-G alleles impact type-specific HPV serological outcomes. METHODS: Altogether, 265 women from the prospective Finnish Family HPV cohort study were included. HLA-G alleles and genotypes were determined by direct DNA-sequenc…
Preclinical Research61 records
Rank106.0
Immunological consequences of mesenchymal stem cell therapy in HPV-driven cervical cancer: A systematic review and stratification framework.
Critical reviews in oncology/hematology · 2026 · PMID 42660395
Over 660,000 women develop cervical cancer annually, caused by persistent infection with high-risk human papillomavirus (HPV). Published studies of mesenchymal stem/stromal cells (MSCs) as immunomodulatory agents are contradictory, with some reporting tumor suppression and others tumor promotion. The mechanism of these paradoxes has not been systematically investigated. This review aims to assess MSC-mediated immune evasion in HPV-related cervical cancer, quantify HPV stratification failure in the literature, and f…
Rank100.0
Immunological and antitumor responses to HPV-targeted therapeutic vaccines in preclinical models of head and neck cancer: a systematic review.
Cancer metastasis reviews · 2026 · PMID 42550292
Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasingly prevalent and accounts for 22-70% of HNSCCs depending on the region. Although prophylactic HPV vaccines were approved in the early 2000s to prevent HPV infection and oncogenesis, they are ineffective against established HPV infections and related cancers. The standard of care for these HPV-associated oropharyngeal cancers combines radiotherapy, surgery, and chemotherapy. However, these treatments can result in signif…
Rank45.0
Therapeutic resistance in HPV-positive oropharyngeal squamous cell carcinoma: molecular mechanisms, clinical challenges, and precision strategies.
Frontiers in genetics · 2026 · PMID 42583380
Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) exhibits exceptional sensitivity to chemoradiotherapy, with 5-year overall survival exceeding 80%, thereby providing a compelling rationale for treatment de-escalation. However, 15%-20% of patients develop therapeutic resistance and locoregional recurrence, resulting in markedly inferior outcomes. This Review systematically dissects the molecular architecture of treatment resistance in HPV-positive OPSCC, with particular emphasis on m…
Rank45.0
Equine genital and ocular squamous cell carcinomas: clinical, histopathological, molecular and viral characterization with proposed histopathological classification system.
The veterinary quarterly · 2026 · PMID 41873836
Equine squamous cell carcinomas (eSCCs) are common, and a proportion are likely induced by Equus caballus papillomavirus 2 (EcPV-2). Accurate prediction of clinical outcomes is challenging with no recognized prognostic criteria or consistent histopathological classification scheme for eSCC. The aims of this study were to histopathologically subtype a large case series of eSCCs (genital and ocular) and correlate them with p16 and HER-2 expression, equine papillomavirus infection status, and various clinical and hist…
Rank45.0
Nanomaterials for the Prevention, Detection, and Treatment of Pharyngeal Human Papillomavirus Infection: A Translational Roadmap.
Materials (Basel, Switzerland) · 2026 · PMID 42590266
Pharyngeal infection with high-risk human papillomavirus (HPV), particularly HPV16, is biologically distinct from cervical infection because it occurs within the specialized lymphoepithelial environment of Waldeyer's ring. This review evaluates nanoparticle materials for the prevention, detection, and treatment of pharyngeal HPV, with an emphasis on structure-property-function relationships, mucosal performance, and translational feasibility. Lipid nanoparticle platforms, polymeric nanoparticle platforms, inorganic…
Rank45.0
Specific and sensitive detection of camel papilloma virus by polymerase chain reaction using novel oligonucleotide primer sequences.
Molecular biology reports · 2026 · PMID 42461455
BACKGROUND: Camel papillomatosis (CP) is caused by camel papillomavirus types 1 (CdPV1) and 2 (CdPV2), leading to noticeable lesions on the facial skin and eyes. Although seldom fatal, it can result in blindness and other deformities as lesions may spread to different body systems, similar to papillomaviruses infection in other animals. Cutaneous lesions in affected camel often resemble to those recorded in camel pox and camel contagious ecthyma (CCE), making accurate diagnosis a difficult task. The present study t…
Rank45.0
Viral etiology of orogenital papillomatosis and squamous cell carcinoma in bottlenose dolphins in the southeastern United States.
Virology · 2026 · PMID 42361430
Orogenital papillomatosis and squamous cell carcinoma is an emerging yet poorly understood complex disease of bottlenose dolphins (Tursiops truncatus and T. erebennus), both in the wild and under managed care. Previous studies have indicated a potential role of papillomaviruses and/or herpesviruses in the development of oncogenesis, although unbiased metagenomic approaches to examine the disease-associated virome in biopsied lesions have not been performed. Herein, we determined the viruses present in oral and geni…
Rank45.0
Equine Sarcoid: From BPV-Driven Oncogenesis to Host-Sustained Tumor Persistence.
Pathogens (Basel, Switzerland) · 2026 · PMID 42654784
Equine sarcoid is the most common cutaneous neoplasm of equids and represents a distinctive model of virus-associated tumor persistence. Although bovine papillomaviruses, particularly BPV-1 and BPV-2, are recognized as the main etiological agents, viral infection alone does not fully explain the clinical heterogeneity, frequent recurrence, and limited spontaneous regression of these lesions. This review summarizes current evidence on the molecular and cellular mechanisms underlying equine sarcoid pathogenesis, with…
Rank45.0
Spontaneous regression of equine sarcoids is an exceptional event.
Equine veterinary journal · 2026 · PMID 41814482
Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition. Although sarcoids have a substantial impact on the health and welfare of affected equids, information on the immune response to bovine papillomavirus infection and resulting sarcoids is limited. However, there is evidence that sarcoid disease is associ…
Rank45.0
Novel avian papillomaviruses identified in a south polar skua sampled on Ross Island, Antarctica.
Archives of virology · 2026 · PMID 42298252
Papillomaviruses are small circular DNA viruses that infect epithelial cells of their hosts. Avian papillomaviruses are poorly sampled/documented compared to those infecting humans. We used a viral metagenomic approach to identify viruses from the oral swab taken from a deceased south polar skua (Stercorarius maccormicki) found at Cape Royds, Ross Island, Antarctica in late 2024. We identified three papillomaviruses and determined their complete genomes, Stercorarius maccormicki papillomavirus (SmacPV) 1-3. SmacPV1…
Rank45.0
Transcriptomic analysis of lncRNA-miRNA-mRNA competing endogenous RNA regulatory networks in radiation-induced mouse thymic degeneration.
Immunologic research · 2026 · PMID 42461346
Excessive or inappropriate radiation can seriously harm organisms. Radiation-induced thymus injury (RITI) is a severe complication driven by dysregulated RNA networks. However, current studies have mostly focused on single non-coding RNAs or late pathological stages, and a complete competing endogenous RNA (ceRNA) regulatory network had not been constructed. The thymus tissues of C57BL/6 mice exposed to 6 Gy X-ray radiation for 24 h were analyzed by RNA-sequencing (RNA-seq) with library construction. We functionall…
Rank45.0
Identification of a novel papillomavirus in the migratory black-headed gull (Chroicocephalus ridibundus) from southwestern China.
Archives of virology · 2026 · PMID 42671616
In the present study, a papillomavirus, designated CrPV1, was identified for the first time in fecal samples collected from black-headed gulls (Chroicocephalus ridibundus) in southwestern China using virus-specific polymerase chain reaction analysis. The complete CrPV1 genome was 7 794 bp in length. Phylogenetic analysis based on the complete genome showed that CrPV1 clustered closely with Columba livia papillomavirus 1 and was clearly distinct from previously reported papillomaviruses, including Psittacus erithacu…
Rank45.0
Topical treatment of equine aural plaques with nitric acid and zinc solution.
Equine veterinary journal · 2026 · PMID 41819501
BACKGROUND: Equine aural plaque caused by equine papilloma viruses is common worldwide and affected horses can show severe clinical signs. Due to its viral aetiology, in some countries affected horses are not allowed to compete. Since lesions persist, showing no spontaneous regression, effective and safe treatment is required. Currently, the only treatment with consistent efficacy is imiquimod. Treatment time is prolonged and adverse effects are common. In humans, papilloma warts are successfully and safely treated…
Rank45.0
Virus infections and cancers: from mechanisms to therapeutics.
Molecular biomedicine · 2026 · PMID 42417944
Viral infections are a major contributor to global cancer incidence and mortality. However, integrative reviews that connect viral classification, carcinogenic mechanisms, tumor microenvironment remodeling, and translational strategies remain limited. This review summarizes the classification and epidemiological characteristics of major oncogenic viruses, including human papillomavirus (HPV), Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), Merkel cell polyomavirus (MCPyV), human T-lympho…
Rank35.0
Multifocal Oral Epithelial Hyperplasia Associated With Papillomavirus Infection in a Road Killed Brown Howler Monkey (Alouatta guariba clamitans).
Journal of medical primatology · 2026 · PMID 42549753
A free-ranging road-killed brown howler monkey (Alouatta guariba clamitans) presented multiple mucosal-colored papules and plaques on oral mucosa. Pathological evaluation confirmed the diagnosis of epithelial hyperplasia with koilocytosis. Papillomavirus antigens were demonstrated by immunohistochemistry, and PCR was positive for partial amplification of Alouatta guariba papillomavirus 1 DNA.
Rank35.0
Fatal 5-Fluorouracil Toxicity With Hyperammonemic Encephalopathy, Lactic Acidosis, and Pneumatosis Intestinalis Despite Uridine Triacetate Rescue: A Case Report.
Cureus · 2026 · PMID 42524480
5-Fluorouracil (5-FU) is among the most widely prescribed chemotherapeutic agents worldwide, yet severe toxicity can produce a life-threatening metabolic syndrome, most commonly associated with dihydropyrimidine dehydrogenase (DPD) deficiency. We report a fatal case of early-onset fluoropyrimidine toxicity characterized by severe metabolic derangements followed by severe myelosuppression. A 56-year-old male patient with stage III (primary tumor (T4), regional lymph nodes (cN2), distant metastasis (cM0), human papil…
Rank35.0
Case Report: Functional characterization of lymphocyte populations in a pediatric patient with WHIM syndrome.
Frontiers in immunology · 2026 · PMID 42445192
WHIM syndrome is a rare primary immunodeficiency disorder caused by gain-of-function mutations of the chemokine receptor CXCR4, leading to abnormal and exacerbated leukocyte trafficking. It is associated with severe neutropenia and lymphopenia, and recurrent infections. Few pediatric cases have been reported, but comprehensive analyses of the composition and function of peripheral lymphocyte populations in pediatric WHIM syndrome are lacking. Here we report the case of a 6-year-old male patient carrying a CXCR4 c.1…
Rank30.0
A calreticulin-linked HPV-16 E7 minigene DNA vaccine elicits strong E7-specific CD8+ T-cell immunity and durable antitumor effects in a preclinical model.
Scientific reports · 2026 · PMID 42399330
Calreticulin (CRT) is an endoplasmic reticulum chaperone that facilitates antigen processing and presentation, making it an attractive fusion partner for enhancing tumor-specific T-cell responses in DNA vaccine development. However, the relative efficacy of CRT compared with other antigen-presentation-enhancing strategies has not been fully evaluated. We constructed a DNA vaccine encoding the immunodominant human papillomavirus (HPV)-16 E7 minigene epitope (aa 49-57) fused to the C-terminus of CRT (pcDNA3-CRT-E7(49…
Rank30.0
A low-dose self-amplifying mRNA vaccine encoding HPV16 E6/E7 induces potent T-cell immunity and antitumor protection in mice.
Cancer immunology, immunotherapy : CII · 2026 · PMID 42400858
BACKGROUND: Human papillomavirus (HPV), particularly high-risk types such as HPV16, is associated with several malignancies, including cervical cancer. Existing therapeutic vaccines targeting HPV oncoproteins E6 and E7 show limited immunogenicity and high production costs. Self-amplifying mRNA (saRNA) vaccines offer a promising alternative by enabling robust antigen expression at low doses. This study evaluated the immunogenicity and antitumor efficacy of a novel saRNA vaccine, JJ-saRNA-HPV01, targeting HPV16 E6/E7…
Rank30.0
Estrogen receptor α (Esr1) mediates estrogen's ability to promote papillomavirus-induced cutaneous disease in male and female mice.
mBio · 2026 · PMID 42212803
Persistent papillomavirus infection is a key driver of neoplastic progression in both mucosal and cutaneous epithelia. Although estrogen is a well-established cofactor in HPV-associated cervical carcinogenesis, its role in cutaneous papillomavirus disease has remained poorly understood. Using a murine papillomavirus type 1 (MmuPV1) infection model in immunocompetent FVB/N mice, we investigated whether estrogen influences viral pathogenesis in infected cutaneous epithelia. Estrogen treatment significantly increased …
Rank30.0
A Spike-Linked HPV16 E7 DNA Vaccine Induces Potent Antitumor and Anti-Spike Immune Responses.
International journal of molecular sciences · 2026 · PMID 42511592
Persistent infection with high-risk human papillomavirus (HPV), particularly HPV16, is a major driver of HPV-associated cancers; however, strategies for treating established HPV-induced tumors remain scarce. Here, we developed a DNA-based vaccine linking the SARS-CoV-2 spike (S) protein with an HPV16 E7 epitope (aa 49-57) to simultaneously induce antiviral humoral immunity and antitumor cellular responses. We generated 2 constructs, S-E7 and S-RE7, with the latter incorporating a furin cleavage site (R) to enhance …
Rank30.0
Pretreatment Chromosomal Instability Correlates With Radiation Sensitivity in Squamous Cell Cancers.
International journal of radiation oncology, biology, physics · 2026 · PMID 41563231
PURPOSE: Continuous chromosome missegregation over successive mitotic divisions, known as chromosomal instability (CIN), is common in cancer. Though it has been associated with treatment resistance and poor prognosis, increasing CIN above a maximally tolerated threshold leads to cell death because of loss of essential chromosomes. Because radiation causes CIN, we hypothesize that pre-existing CIN sensitizes tumor cells to radiation therapy. METHODS AND MATERIALS: We induced mitotic defects that lead to CIN in FaDu …
Rank30.0
Targeting metabolic reprogramming in HPV-associated oral squamous cell carcinoma: current advances, challenges, and clinical prospects.
Journal of molecular histology · 2026 · PMID 42371183
Human papillomavirus (HPV)-associated oral squamous cell carcinoma (OSCC) is increasingly investigated as a potentially distinct subset of head and neck cancers with unique molecular features. In contrast to HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), which demonstrates a well-established favorable prognosis, the prognostic significance of HPV in OSCC remains inconsistent and continues to be actively investigated. HPV oncoproteins E6 and E7 are known to induce metabolic rewiring in HPV-driven cancer…
Rank30.0
mRNA vaccines targeting HPV E6/E7: A new frontier in cervical cancer immunotherapy.
Critical reviews in oncology/hematology · 2026 · PMID 42556594
Human papillomavirus (HPV) infections, particularly high-risk types 16 and 18, are responsible for approximately 70% of cervical cancer cases worldwide. Despite the availability of effective prophylactic vaccines, therapeutic interventions for established HPV-associated malignancies remain limited. This mini-review synthesizes recent advances (2020-2026) in mRNA-LNP vaccine development targeting the HPV E6 and E7 oncoproteins. We examine the mechanistic basis for targeting E6/E7, technological advantages of mRNA-LN…
Rank30.0
Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer.
Translational oncology · 2026 · PMID 42551127
BACKGROUND: Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. METHODS: We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical data to analyze cervical cancer heterogeneity. scRNA-seq, inferCNV, and pseudotime analysis characterized HPV-associated cellular features and malignant transformation. hdWGCNA identified core gene modules. Univariate Cox, Lasso, and mult…
Promising Experimental Therapies61 records
Rank107.5
Video-based interventions to promote HPV vaccination among individuals aged 9 to 26: a systematic review and meta-analysis.
BMC public health · 2026 · PMID 41826914
Human papillomavirus (HPV) is the most prevalent sexually transmitted infection in the U.S. and is associated with approximately 40,000 new cancer cases each year, affecting both males (e.g., oropharyngeal, anal cancers) and females (e.g., cervical, vaginal cancers). The CDC recommends HPV vaccination for individuals aged 9 to 26, and studies have shown that HPV vaccines are effective in reducing the rates of cancers. Video-based interventions may be an effective strategy to increase vaccination uptake. This study …
Rank99.8
Comparing paclitaxel and platinum-based concurrent chemoradiotherapy with short-term adjuvant chemotherapy versus platinum-based monotherapy concurrent chemoradiotherapy in patients with postoperative gastric-type endocervical adenocarcinoma with high-risk factors for recurrence: a multicenter randomized phase III trial.
Journal of gynecologic oncology · 2026 · PMID 41834413
BACKGROUND: Gastric-type endocervical adenocarcinoma (G-EAC) is a distinctive form of adenocarcinoma that is not associated with human papillomavirus. This neoplasm exhibits a low incidence, low screening and biopsy positivity, low preoperative diagnosis, and a high susceptibility to underdiagnosis and misdiagnosis. It is associated with a poor prognosis for patients. Currently, there is an absence of a standardized postoperative adjuvant treatment plan for G-EAC, which constitutes an urgent clinical problem that d…
Rank98.6
Induction Nivolumab Before Chemoradiation in High-Risk Human Papillomavirus-Driven Oropharynx Cancers: IMMUNEBOOST-HPV, a Multicenter Randomized Phase II Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 41570275
PURPOSE: Patients with human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) and advanced stage and/or significant smoking history are at higher risk of relapse. Induction immunotherapy before chemoradiation (CRT) may improve outcomes. This randomized phase II trial assessed the feasibility and safety of induction nivolumab before CRT in this high-risk population. METHODS: Eligible patients had HPV-positive OPC with either T4 and/or N2/N3 disease or a smoking history >10 pack-years. Patients were randomly …
Rank98.5
Immunogenicity and safety of a quadrivalent recombinant human papillomavirus vaccine (type 6/11/16/18) (Hansenula polymorpha): A randomized controlled phase 2 non-inferiority clinical trial.
Vaccine · 2026 · PMID 41932289
OBJECTIVE: The randomized, double-blind, placebo-controlled Phase II non-inferiority clinical study aimed to evaluate the immunogenicity and safety of the quadrivalent recombinant human papillomavirus vaccine (type 6/11/16/18) (Hansenula polymorpha) in healthy females aged 9-45 years. METHODS: A total of 1800 participants were randomly assigned to the vaccine group and the placebo group in a 2:1 ratio. The immunobridging between the 9-17 and 18-45 age groups adopts a non-inferiority design with a non-inferiority ma…
Rank97.6
Efficacy and safety of a topical nitric oxide-releasing solution (NORS) as a noninvasive treatment for plantar warts (verrucae plantaris).
The Journal of dermatological treatment · 2026 · PMID 41493215
BACKGROUND: Plantar warts (verrucae plantaris), caused by human papillomavirus, are common and often resistant to standard therapies, which can be painful and damaging. Novel, noninvasive options are needed. OBJECTIVE: To evaluate the safety and preliminary efficacy of a topical nitric oxide-releasing solution (NORS) as a self-administered therapy for plantar warts. METHODS: In this Phase 2a, multicenter, randomized, double-blind, placebo-controlled trial, 20 participants with ≥3 plantar warts were randomized (1:1:…
Rank96.4
Effectiveness of different educational interventions on knowledge, attitude and willingness to undergo cervical cancer screening in rural Indonesia: a quasi-experimental study.
BMJ open · 2026 · PMID 42575548
OBJECTIVES: The low uptake of cervical cancer screening (CCS) in rural areas is mainly related to the lack of awareness regarding cervical cancer. Using educational interventions has been shown to substantially improve knowledge and attitude towards cervical cancer, which are important determinants of undergoing CCS. The aim of this study was to analyse the impact of different educational intervention methods on knowledge, attitudes and willingness to undergo CCS among women in rural Indonesia. DESIGN: A quasi-expe…
Rank95.7
A Phase 1b/2, Randomised, Placebo-controlled Study to Evaluate Safety, Tolerability, Efficacy, and Immunogenicity of VTP-200, a Chimpanzee Adenovirus and Modified Vaccinia Ankara-vectored Multigenotype High-risk Human Papillomavirus Vaccine in Women With Low-grade Cervical Lesions.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41403292
BACKGROUND: The clearance of high-risk oncogenic human papillomaviruses (hrHPV) and related cervical lesions is associated with the development of a robust T-cell response. Therapeutic vaccination that induces HPV antigen-specific T cells is a promising approach. METHOD: A 2-vector dosing strategy using Chimpanzee Adenovirus Oxford 1-HPV and Modified Vaccinia virus Ankara-HPV, both encoding the same multiantigen HPV cassette was given on a 0/28-day schedule to participants with persistent cervical hrHPV and a histo…
Rank92.0
A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence.
Oncotarget · 2026 · PMID 42249801
UNLABELLED: Copyright: © 2026 Bivens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. OBJECTIVES: The main goals were to assess safety and efficacy (i.e., recurrence reduction). RESULTS: Seventeen patients were enrolled. The most common adverse events were grades 1 and 2 injection site reactions, and they oc…
Rank92.0
The effect of podcasts delivered to female university students on HPV knowledge, awareness, and anxiety levels: A randomized controlled trial.
Nurse education in practice · 2026 · PMID 42314452
AIM: The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). METHOD: This randomized controlled experimental study was conducted between 7 April 2025 and 6 June 2025, with a total of 211 students (99 in the intervention group and 112 in the control group) who were enrolled in the 2024-2025 academic year at the Faculty of Health Sciences, University of Health Sciences Gülhane and…
Rank85.0
Technological innovations in head and neck radiotherapy: What does the future hold?
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2026 · PMID 42001737
Radiotherapy in head and neck oncology is advancing thanks to technologies that improve treatment precision, adaptation, and tolerance. The most promising approaches are discussed in this narrative review. The use of automatic segmentation through artificial intelligence (deep learning) now allows rapid delineation of organs at risk, thus reducing contouring time and the risk of errors. Several tools are already routinely used and are evaluated for replanning process. Imaging, acquired before each session, ensures …
Rank81.1
Phase 2 Prospective Trial of Personalized Radiation Therapy Fractionation in Human Papillomavirus Positive Oropharyngeal Cancer.
International journal of radiation oncology, biology, physics · 2026 · PMID 41519405
PURPOSE: We previously developed a model of pretreatment growth and on-treatment response dynamics, the proliferation saturation index (PSI) model, which derives the proliferating and radiosensitive proportion of a tumor based on clinically observed net growth before therapy. We hypothesized that personalization of fractionation using PSI would increase the percentage of patients achieving a rapid reduction in tumor size during radiation therapy (RT) for early-stage human papillomavirus related squamous cancers of …
Rank81.0
Amivantamab in Recurrent/Metastatic Head and Neck Squamous Cell Cancer After Checkpoint Inhibitor and Chemotherapy: Pivotal Results From the Phase Ib/II OrigAMI-4 Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 42218660
Single-agent paclitaxel or cetuximab after immune checkpoint inhibitor (ICI) and chemotherapy demonstrated objective response rates (ORRs) of 21%-24% in recurrent/metastatic (R/M) head/neck squamous cell cancer (HNSCC). Epidermal growth factor receptor (EGFR) and MET are overexpressed in R/M HNSCC. Amivantamab, an EGFR-MET bispecific antibody, may be a rational treatment. Cohort 1 of OrigAMI-4 (ClinicalTrials.gov identifier: NCT06385080) evaluated subcutaneous amivantamab administered every 3 weeks in participants …
Rank81.0
Risk-adapted therapy guided by human papillomavirus (HPV) circulating tumor DNA in HPV-positive oropharyngeal cancer (ReACT 1.0): an exploratory phase II trial.
Nature communications · 2026 · PMID 42098120
Circulating tumor DNA (ctDNA) has an expanding role in oncology. It is unknown whether on-treatment ctDNA can be used to personalize radiation dose. This phase 2 exploratory clinical trial enrolled 102 patients with human papillomavirus (HPV)-positive oropharyngeal carcinoma (OPC). Intermediate-risk patients (T4 disease or >10 pack-year smokers with pre-treatment HPV ctDNA scores >200) were reclassified as low-risk if HPV ctDNA cleared by >95% mid-treatment. All clinically low-risk and reclassified patients receive…
Rank80.2
A Phase 2 Exploratory Trial Evaluating Computed Tomography-Based Midtreatment Nodal Response to Select for De-escalated Chemoradiation Therapy in the Definitive Management of p16+ Oropharyngeal Cancer.
International journal of radiation oncology, biology, physics · 2026 · PMID 41101558
PURPOSE: This prospective, nonrandomized phase 2 single-arm pilot trial aimed to explore favorable midtreatment nodal response (FMNR) through computed tomography (CT) imaging to guide de-escalated chemoradiation therapy (CRT) in patients with favorable risk, node-positive human papillomavirus (HPV)-associated oropharyngeal cancer (OPC). METHODS AND MATERIALS: Eligible patients included p16+ OPC (AJCC 8th: cT1-3 N1 M0, <10 pack-year smokers). All patients were initially planned to receive 70 Gy with concurrent weekl…
Rank80.0
FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 41385605
PURPOSE: We conducted a phase II multicenter clinical trial to test the hypothesis that 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)-based chemoradiation (CRT) dose deescalation would provide noninferior locoregional control compared with historical controls among patients with early-stage p16+ oropharyngeal cancer. We also hypothesized that human papillomavirus (HPV) circulating tumor DNA (ctDNA) changes during treatment predict locoregional recurrence (LRR). PATIENTS AND METHODS: Patients with st…
Rank77.0
Phase I/II clinical study of next-generation photodynamic therapy (L-PDT) using talaporfin sodium (Laserphyrin®) for cervical intraepithelial neoplasia: Efficacy, safety, and fertility preservation.
Photodiagnosis and photodynamic therapy · 2026 · PMID 41638379
BACKGROUND: PDT using Photofrin® (P-PDT) has been applied to over 900 gynecologic tumor cases since 1989, demonstrating excellent efficacy and fertility preservation; however, post-treatment photosensitivity has limited its clinical application for CIN and cervical cancer. This study aimed to establish a safe, effective, and fertility-preserving alternative to cervical conization. METHODS: To overcome photosensitivity, we conducted a prospective Phase I/II clinical study to evaluate the safety, efficacy, oncologica…
Rank77.0
Continuous Infusion of the CXCR4 Antagonist Plerixafor for WHIM Syndrome.
Journal of clinical immunology · 2026 · PMID 41904735
BACKGROUND: WHIM (Warts, Hypogammaglobulinemia, Infections and Myelokathexis) syndrome is an ultrarare inborn error of immunity caused by heterozygous, hyperfunctional CXCR4 mutations that impede leukocyte egress from bone marrow, resulting in panleukopenia. The CXCR4 antagonist plerixafor (AMD3100, Mozobil) durably reverses panleukopenia and in most WHIM patients also induces wart regression; however, its short half-life requires twice daily injection. OBJECTIVE: The aim of this study was to assess the safety and …
Rank68.2
Ficerafusp Alfa (BCA101) With Pembrolizumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Two-Year Results of an Expansion Cohort of a Phase I/Ib Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 42102329
PURPOSE: Patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) have a poor prognosis, particularly those with human papillomavirus (HPV)-negative disease, in which elevated epidermal growth factor receptor and transforming growth factor-β impair tumor penetration of immune cells and lessen immunotherapy responses. METHODS: We present results from an expansion cohort of a first-in-human phase I/Ib trial (ClinicalTrials.gov identifier: NCT04429542) evaluating first-line treatment wit…
Rank55.0
Early effects of HPV vaccination on high-grade cervical intraepithelial neoplasia in Brazil: Evidence from outpatient data.
Human vaccines & immunotherapeutics · 2026 · PMID 42295873
Cervical cancer remains a leading cause of disease burden among women, despite being largely preventable. High-grade cervical intraepithelial neoplasia (CIN) is a key intermediate outcome for evaluating early population-level effects of HPV vaccination and is mainly managed in outpatient settings, which may provide a more timely signal than hospitalizations or cancer registry data. This study aimed to assess whether the introduction of quadrivalent HPV vaccination in Brazil in 2014 through its National Immunization…
Rank50.3
The role of E7 oncoprotein self-sampling and self-testing in cervical cancer screening.
BMC women's health · 2026 · PMID 41692769
OBJECTIVE: To preliminarily explore and validate the role of E7 oncoprotein self-sampling and self-testing in cervical cancer screening. METHODS: Approved by the Ethics Committee of Peking University First Hospital, 461 patients who underwent cervical cancer screening with abnormal screening results in the outpatient clinic from June 13, 2023 to August 29, 2023 were selected and participated in the clinical trial with informed consent. For E7 oncoprotein, the participants use self-sampling brushes to collect sample…
Rank50.0
Association of Intratumoral Microbiota with Prognosis in Head and Neck Squamous Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 41758690
PURPOSE: To evaluate whether intratumoral bacterial load and diversity are associated with survival outcomes in head and neck squamous cell carcinoma (HNSCC) and to examine their relationship with human papillomavirus (HPV) status. EXPERIMENTAL DESIGN: This retrospective cohort study included 312 adults with surgically treated, primary HNSCC at Montefiore Einstein Cancer Center (2000-2023). Intratumoral bacterial load was quantified via quantitative PCR (qPCR), and microbial diversity was assessed via 16S ribosomal…
Rank49.8
Molecular and Immune Landscape of Recurrent and/or Distant Metastatic Squamous Cell Carcinoma of the Head and Neck: An EORTC/IMMUCAN Project.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 41870278
PURPOSE: Recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is a heterogeneous clinical entity with a poor prognosis. The molecular and immune landscape of R/M SCCHN is underexplored. To offer a comprehensive view of the tumor microenvironment and molecular profile of R/M SCCHN, we performed an in-depth molecular and immune characterization, evaluating the impact of human papillomavirus (HPV) status, tobacco and alcohol history, primary tumor site, relapse pattern, and treatment …
Rank49.8
Effects of message framing on HPV Vaccination decision-making: A Survey experiment among Chinese male college students.
Human vaccines & immunotherapeutics · 2026 · PMID 41480936
Human papillomavirus (HPV) is a major public health concern affecting both sexes. China adopted a gender-neutral HPV vaccination strategy, expanding recommendations to include males. College students, a high-risk group for HPV exposure, were a priority target for vaccination campaigns. This study compares how four message frames (control, personal health risks, partner risks, both risks) influenced HPV vaccination intention, decisional readiness, and perceived responsibility among Chinese male college students. We …
Rank49.2
The Role of Enterococcus faecium in the Synergistic Clearance of High-Risk HPV: A Clinical Study on Cervicovaginal Microbiota Regulation.
Cancer medicine · 2026 · PMID 42337942
BACKGROUND: Persistent infection with high-risk human papillomavirus (HR-HPV) is defined as the principal cause of cervical cancer. Given the important role of cervicovaginal microbiota in HPV acquisition and disease progression, this study aims to evaluate the clinical efficacy of the probiotic Enterococcus faecium (E. faecium) in synergistically promoting clearance of persistent HR-HPV infection. METHODS: We conducted a prospective clinical study involving 365 female patients with persistent HR-HPV infection. Fol…
Rank49.1
Incremental impact of community-delivered HPV self-sampling on screening uptake within an active outreach system: A quasi-experimental implementation study in rural Thailand.
PloS one · 2026 · PMID 42224174
BACKGROUND: Thailand has still not achieved the cervical cancer screening coverage target set by the World Health Organization (WHO). Although HPV self-sampling has been introduced to reduce access barriers, delivery remains largely facility-based, requiring women to attend primary care units during working hours. Community-delivered approaches have been proposed as an alternative; however, evidence comparing strategies within the same service context remains limited. This study aimed to assess the incremental bene…
Prospective Cohort Studies67 records
Rank100.6
Comparison of three different hpv self-sampling tools - a subanalysis of the prospective, randomized hannover self-collection study.
Archives of gynecology and obstetrics · 2026 · PMID 42347973
OBJECTIVE: Cervical cancer and its precursor lesions are treatable if detected early; however, screening participation for high-risk human papillomavirus infections (hr-HPV) remains low. In 2021, Germany recorded 4,544 new cervical cancer cases and 2,071 related deaths. The HaSCo study evaluates the feasibility of HPV self-testing to improve screening participation. This sub-study evaluates performance and acceptability of three self-testing tools. METHODS: This prospective, randomized sub-study examined Evalyn-Bru…
Rank99.8
Comparing paclitaxel and platinum-based concurrent chemoradiotherapy with short-term adjuvant chemotherapy versus platinum-based monotherapy concurrent chemoradiotherapy in patients with postoperative gastric-type endocervical adenocarcinoma with high-risk factors for recurrence: a multicenter randomized phase III trial.
Journal of gynecologic oncology · 2026 · PMID 41834413
BACKGROUND: Gastric-type endocervical adenocarcinoma (G-EAC) is a distinctive form of adenocarcinoma that is not associated with human papillomavirus. This neoplasm exhibits a low incidence, low screening and biopsy positivity, low preoperative diagnosis, and a high susceptibility to underdiagnosis and misdiagnosis. It is associated with a poor prognosis for patients. Currently, there is an absence of a standardized postoperative adjuvant treatment plan for G-EAC, which constitutes an urgent clinical problem that d…
Rank96.6
Evaluation of the Efficacy of Human Papillomavirus Screening Compared With Cytology Screening in Pregnant Women: Protocol for a Prospective Multicenter Trial.
JMIR research protocols · 2026 · PMID 42348863
BACKGROUND: Although the overall number of cervical cancer cases is declining worldwide, the incidence of this type of cancer is increasing in regions with low human papillomavirus (HPV) vaccination and cancer screening rates. In such regions, screening pregnant women can help improve the overall screening rate. Worldwide, cervical cancer screening is shifting from cervical cytology to HPV testing, which reduces the incidence of cervical cancer and, when negative, allows for longer screening intervals. Although HPV…
Rank96.4
Immunogenicity and Safety of 2 Versus 3 Doses of 9-Valent Vaccine Against Human Papillomavirus in Women With Human Immunodeficiency Virus: The Papillon Randomized Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 40356381
BACKGROUND: The World Health Organization recommends 2 doses of human papillomavirus (HPV) vaccine for adults without human immunodeficiency virus (HIV) but 3 doses in persons with HIV. There are no immunogenicity data on the 2-dose schedule in women with HIV (WWH). METHODS: This was a prospective study comparing 2 doses (months 0 and 6) versus 3 (months 0, 2, and 6) doses of 9-valent vaccine (Gardasil 9, Merck Sharp & Dohme) in WWH (15-40 years), on antiretrovirals with HIV RNA <400 copies/mL, enrolled during 2018…
Rank96.3
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
The New England journal of medicine · 2022 · PMID 35704479
BACKGROUND: The incidence of anal cancer is substantially higher among persons living with the human immunodeficiency virus (HIV) than in the general population. Similar to cervical cancer, anal cancer is preceded by high-grade squamous intraepithelial lesions (HSILs). Treatment for cervical HSIL reduces progression to cervical cancer; however, data from prospective studies of treatment for anal HSIL to prevent anal cancer are lacking. METHODS: We conducted a phase 3 trial at 25 U.S. sites. Persons living with HIV …
Rank89.9
Adjuvant VaccInation After Conization for the Treatment for CervicAL Dysplasia.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026 · PMID 40277212
This study aimed to evaluate the role of adjuvant HPV vaccination in women undergoing conization for cervical intraepithelial neoplasia. This prospective study assessed factors influencing recurrence in patients undergoing conization for high-grade cervical dysplasia. After conization, patients were counseled on the potential benefits of vaccination. We compared outcomes between two groups: women who underwent conization with adjuvant human papillomavirus (HPV) vaccination and observation versus conization with obs…
Rank85.0
Comparison of Moducare versus Wait-and-See approach for histologically proven Low-grade Cervical Intraepithelial Neoplasia (CIN1) (MODUCIN1 TRIAL) - Study protocol.
PloS one · 2026 · PMID 42441577
Human Papillomavirus (HPV) is causally associated with cervical cancer and precancerous lesions (dysplasias) of the cervix. The treatment of choice for low-grade lesions is monitoring with no-treatment, because the majority of them will regress spontaneously. However, this wait-and-see approach can be assisted by nutritional supplements for immune support, like Moducare. The hypothesis of the trial is that Moducare can enhance the natural regression of CIN1. MODUCIN1 is a prospective, open-label, randomized trial w…
Rank85.0
Increasing HPV vaccine promotion by dental providers: A clinical trial protocol.
Contemporary clinical trials · 2026 · PMID 41539537
BACKGROUND: Human papillomavirus is a prevalent DNA virus and the leading cause of both oropharyngeal and cervical cancer. Despite the availability of an effective vaccine (HPV-V), uptake is below national targets. A behavioral intervention, Increasing HPV Vaccine Uptake - Delivered in Dental Settings (HPV-V Uptake-DDS), was developed to support dental providers in promoting HPV-V to their patients to help close this gap. OBJECTIVES: This protocol for an efficacy trial of HPV-V Uptake-DDS is designed to increase HP…
Rank81.1
Phase 2 Prospective Trial of Personalized Radiation Therapy Fractionation in Human Papillomavirus Positive Oropharyngeal Cancer.
International journal of radiation oncology, biology, physics · 2026 · PMID 41519405
PURPOSE: We previously developed a model of pretreatment growth and on-treatment response dynamics, the proliferation saturation index (PSI) model, which derives the proliferating and radiosensitive proportion of a tumor based on clinically observed net growth before therapy. We hypothesized that personalization of fractionation using PSI would increase the percentage of patients achieving a rapid reduction in tumor size during radiation therapy (RT) for early-stage human papillomavirus related squamous cancers of …
Rank80.8
HPV testing with 16/18 genotyping for risk stratification among women with normal cytology: a multicenter prospective cohort study from China.
Journal of clinical microbiology · 2026 · PMID 41711488
UNLABELLED: To evaluate the clinical performance of Hybribio's 14-type HPV real-time PCR with 16/18 genotyping (HBRT-H14) and its risk stratification utility among women with normal cytology (NILM). From 2017 to 2020, a multicenter cohort enrolled 8,401 women aged 30-64 years with NILM cytology. Baseline HPV testing used HBRT-H14. Women positive for HPV 16/18 were referred for colposcopy; follow-up was annual for 3 years or until the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Analyses…
Rank80.5
SOX1/PAX1 Methylation for Triage of HPV-Positive Women in Cervical Cancer Screening: A Cohort Study.
BJOG : an international journal of obstetrics and gynaecology · 2026 · PMID 41555581
OBJECTIVE: To establish a better triage strategy using SOX1/PAX1 methylation detection for high-risk HPV (hrHPV)-positive women than cytology. DESIGN: A cohort study. SETTING: Population-based cervical cancer (CC) screening cohort. POPULATION: A total of 5684 women were enrolled. METHODS: SOX1/PAX1 methylation was detected by quantitative methylation-specific PCR using cytologic residue from hrHPV-positive women at baseline in a 3-year CC screening cohort. Risk stratification ability was evaluated by the immediate …
Rank79.7
Risk of High-Grade Cervical Intraepithelial Neoplasia Using human Papillomavirus Extended Genotyping in Chinese Women With Normal Cervical Cytology: A Population-Based Screening Cohort.
Journal of medical virology · 2026 · PMID 42124388
To evaluate the risk of cervical intraepithelial neoplasia, grade 2 or worse (≥ CIN2) in women with normal cervical cytology using extended high-risk human papillomavirus (HR-HPV) genotyping. This study is a population-based, nationwide, multi-center prospective cohort study. A subset of 6853 women with normal cytology and HPV testing results using an extended genotyping assay were included in the analysis. The odds ratio (OR) and adjusted OR (aOR) was calculated using univariate analyses and multivariate logistic …
Rank77.0
Phase I/II clinical study of next-generation photodynamic therapy (L-PDT) using talaporfin sodium (Laserphyrin®) for cervical intraepithelial neoplasia: Efficacy, safety, and fertility preservation.
Photodiagnosis and photodynamic therapy · 2026 · PMID 41638379
BACKGROUND: PDT using Photofrin® (P-PDT) has been applied to over 900 gynecologic tumor cases since 1989, demonstrating excellent efficacy and fertility preservation; however, post-treatment photosensitivity has limited its clinical application for CIN and cervical cancer. This study aimed to establish a safe, effective, and fertility-preserving alternative to cervical conization. METHODS: To overcome photosensitivity, we conducted a prospective Phase I/II clinical study to evaluate the safety, efficacy, oncologica…
Rank76.4
HPV Status and Genotype Associations with Nodal Involvement and Treatment Strategy in Bulgarian Patients with Head and Neck Squamous Cell Carcinoma: A Prospective Multicenter Observational Study.
Medicina (Kaunas, Lithuania) · 2026 · PMID 42356035
Background and Objectives: Head and neck squamous cell carcinoma (HNSCC) is a biologically heterogeneous malignancy with variable clinical behavior and prognosis. Human papillomavirus (HPV)-associated tumors represent a distinct subgroup; however, data from Eastern European populations remain limited. This study aimed to evaluate the association between HPV DNA status and nodal involvement in a Bulgarian HNSCC cohort and to explore whether HPV genotype distribution is related to nodal involvement and therapeutic st…
Rank73.8
Expanded subtype testing for circulating tumor HPV DNA reliably detects the presence of advanced-stage cervical cancer.
Gynecologic oncology · 2026 · PMID 42000375
OBJECTIVES: To demonstrate the detection of circulating human papillomavirus (HPV) DNA fragments can serve as a biomarker for presence of tumor and provide a universal, non-invasive tool for monitoring treatment response in HPV-related cervical cancers (CC). METHODS: A multi-site prospective study of HPV-positive high-grade cervical dysplasia (CIN2/3) and CC was conducted. Serum samples were collected pre-, during, and post-treatment. NavDx® (Naveris,Inc) digital droplet polymerase chain reaction testing was used t…
Rank73.0
Baseline Nutritional Status and Early Treatment Response in Oropharyngeal Cancer: A Prospective Cohort Study by HPV Status (FIS 19 Study).
Nutrients · 2026 · PMID 42451094
Background/Objectives: Human papillomavirus (HPV) is a well-established prognostic marker in oropharyngeal squamous cell carcinoma (OPSCC); however, the short-term treatment response remains heterogeneous, particularly among HPV-positive patients. Given the high prevalence of malnutrition in head and neck cancer, this study examined whether baseline nutritional status, body composition and functional status were associated with early treatment response in OPSCC according to HPV status. Methods: A prospective observ…
Rank73.0
REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective study.
World journal of surgical oncology · 2026 · PMID 42035080
OBJECTIVE: To evaluate the efficacy of REBACIN® as a non-invasive treatment for persistent high-risk HPV (HR-HPV) clearance compared with interferon and no treatment, identify optimal cutoff values for HPV E6/E7 mRNA/DNA assays, analyze clinical predictors, and validate REBACIN® as a safe alternative to invasive interventions for cervical cancer prevention. METHODS: According to the predefined inclusion and exclusion criteria, eligible patients were randomly selected and enrolled after obtaining their informed cons…
Rank70.6
From Awareness to Action Study: Improving Human Papillomavirus Knowledge, Screening and Vaccine Uptake Among Mother-Adolescent Pairs in the HOMINY Study in Nigeria: A Longitudinal Study.
Journal of the International AIDS Society · 2026 · PMID 42499163
INTRODUCTION: Persistent cervical infection with high-risk human papillomavirus (HPV) in women is a leading cause of cervical cancer, and its co-infection among people living with HIV increases the risk of other HPV-associated cancers, including oropharyngeal and anogenital cancers. In sub-Saharan Africa, awareness of HPV is limited, screening and vaccine adoption are critically low, undermining efforts towards sexually transmitted infection (STI) elimination. METHODS: From Awareness to ACTion (FACT) study assessed…
Rank70.1
Conservative Management of CIN2 Within Primary HPV Cervical Cancer Screening Programme: A Cohort Study.
Journal of lower genital tract disease · 2026 · PMID 41589748
OBJECTIVES: To quantify the probabilities of becoming HPV-negative, or receiving delayed treatment within 24 months in women with CIN2 managed conservatively; describing the determinants of the decision for conservative management, losses to follow-up and outcomes. METHODS: This prospective cohort included biopsy-confirmed CIN2 from HPV-based pilot screening in Valcamonica, Italy. Women aged 45 and under, with no glandular lesion, and assessed as low-risk by gynecologists were offered conservative management instea…
Rank70.0
The Australian Penile Cancer Clinical Registry: a comprehensive national approach to data collection.
BJU international · 2026 · PMID 41810702
BACKGROUND: Penile cancer is a rare malignancy, with an Australian incidence of 0.6 in 100 000 men, with a wide range of clinical presentations, from localised, curable tumours to aggressive forms with high morbidity and mortality. Epidemiological data and management guidelines for penile cancer in Australia are limited. The Australian Penile Cancer Clinical Registry (APCCR) aims to address this gap through a centralised database studying local risk factors, treatment effectiveness, and outcomes. STUDY DESIGN: The …
Rank69.9
Natural history of anal HSIL and predictive value of cytology and HPV biomarkers in MSM living with HIV: A prospective cohort study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · PMID 42264069
OBJECTIVES: Men who have sex with men (MSM) living with HIV are at high risk for anal cancer, which arises from HPV-related high-grade squamous intraepithelial lesions (HSIL). This study describes natural history of HSIL and identifies predictors of incidence and clearance using HPV DNA and E6/E7 mRNA biomarkers. METHODS: Prospective cohort of 354 MSM with HIV, followed for 2-4 years. Visitsisits included anal cytology, HPV DNA/mRNA testing, and high-resolution anoscopy. Composite cytological and histological outco…
Rank69.6
Cervical Cancer Screening With Human Papillomavirus Self-Collection Testing in an Opioid Treatment Program.
JAMA network open · 2026 · PMID 42525415
IMPORTANCE: Individuals with opioid use disorder and substance use disorder have lower cervical cancer screening rates than the general population. Human papillomavirus (HPV) self-collection testing provides opportunities to expand screening access to previously unreached patient populations. OBJECTIVES: To assess the feasibility and uptake of incorporating HPV self-collection testing for cervical cancer screening into routine care for patients with opioid use disorder and substance use disorder, and to track the r…
Rank68.0
Long-Term Prospective Cohort Study of Cervical Cancer Screening Using Triage of Women Who Are Human Papillomavirus-Positive With Dual Stain and Human Papillomavirus Genotyping.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 41701950
PURPOSE: Primary human papillomavirus (HPV) testing has the best tradeoff of benefits and harms for cervical screening but requires triage to determine management among HPV positives. We conducted a prospective observational study to evaluate triage of women who are HPV-positive using dual stain (DS) and HPV genotyping. MATERIALS AND METHODS: We included 9,645 consecutive women who are HPV-positive undergoing cervical screening in two periods between 2015 and 2017 in the organized cervical screening program at Kais…
Rank65.4
Risk of HSIL/CIN2+ Lesions in Women with Negative Cytology and High-Risk HPV Referred to Colposcopy: Experience in a Population-Based Screening Program.
Medicina clinica · 2026 · PMID 42140079
OBJECTIVE: To assess the prevalence of HSIL/CIN2+ lesions in women with negative cytology and high-risk HPV (HR-HPV) referred to colposcopy from population-based screening, as well as to describe histological findings and the need for excisional treatment. METHODS: Prospective observational study (November 2022-June 2025). Included were women referred to colposcopy with negative cytology and positive HR-HPV results: (1) HPV16/18, (2) persistent non-16/18 HR-HPV, (3) HPV16/18 + HR-HPV co-infection, and (4) non-16/18…
Rank65.0
A prospective cohort study on the association between cervical microenvironmental factors and the efficacy of treating high-risk human papillomavirus infection comorbid with cervical diseases.
Frontiers in cellular and infection microbiology · 2026 · PMID 41884530
OBJECTIVE: Interferon-based local therapy is an intervention for high-risk human papillomavirus (HR-HPV)-associated low-grade squamous intraepithelial lesions (LSIL) or lower-grade cervical abnormalities. This study sought to delineate the differences in clinical outcomes following interferon-based local drug treatment and elucidate the microenvironmental factors driving these disparities. METHODS: Cervical secretions, cell brush specimens, and cervical tissue samples were collected from patients with persistent HR…
Quality Of Life61 records
Rank107.1
Subsequent-line Systemic Therapy for Metastatic or Recurrent Penile Cancer: A Systematic Review of Efficacy, Toxicity, and Outcomes.
European urology focus · 2026 · PMID 41519649
BACKGROUND AND OBJECTIVE: Treatment options for metastatic or recurrent penile squamous cell carcinoma (PSCC) progressing after first-line platinum-based chemotherapy are limited, and no standard subsequent-line systemic therapy exists. We systematically reviewed the efficacy, safety, and survival outcomes of second- and later-line systemic treatments in this setting. METHODS: A systematic review, compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, was performed across …
Rank105.8
Transoral robotic surgery versus definitive (Chemo)radiotherapy in early HPV-positive oropharyngeal cancer: A systematic review and meta-analysis of oncologic outcomes.
Oral oncology · 2026 · PMID 41806530
INTRODUCTION: Although individual studies suggest similar oncologic outcomes between transoral robotic surgery (TORS) and definitive (chemo)radiotherapy (RT/CRT) for early-stage human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC), oncologic and functional outcomes have not been systematically synthesized. OBJECTIVE: To compare oncologic and functional outcomes of a primary surgery-based strategy versus a primary definitive RT/CRT strategy in early-stage HPV-OPSCC. METHODS: PubMed, Embase…
Rank100.3
Cost-effectiveness of cervical cancer screening among women living with HIV in India: study protocol.
BMJ open · 2026 · PMID 41617241
INTRODUCTION: Women living with HIV (WLHIV) face a higher risk of developing cervical cancer. India carries a significant burden of HIV, with an estimated 2.5 million people living with HIV in 2023. While the introduction of more effective antiretroviral therapy has improved the life expectancy of WLHIV, it has also extended the risk window for persistent human papillomavirus (HPV) infection and cervical disease progression. Cervical cancer prevention through HPV vaccination and regular screening remains the corner…
Rank99.8
Comparing paclitaxel and platinum-based concurrent chemoradiotherapy with short-term adjuvant chemotherapy versus platinum-based monotherapy concurrent chemoradiotherapy in patients with postoperative gastric-type endocervical adenocarcinoma with high-risk factors for recurrence: a multicenter randomized phase III trial.
Journal of gynecologic oncology · 2026 · PMID 41834413
BACKGROUND: Gastric-type endocervical adenocarcinoma (G-EAC) is a distinctive form of adenocarcinoma that is not associated with human papillomavirus. This neoplasm exhibits a low incidence, low screening and biopsy positivity, low preoperative diagnosis, and a high susceptibility to underdiagnosis and misdiagnosis. It is associated with a poor prognosis for patients. Currently, there is an absence of a standardized postoperative adjuvant treatment plan for G-EAC, which constitutes an urgent clinical problem that d…
Rank97.0
Intralesional Interferon Alfa-2b Versus Cryotherapy for Common Warts on the Hands and Feet: A Randomized, Open-Label, Controlled Trial.
Journal of cosmetic dermatology · 2026 · PMID 41693220
OBJECTIVE: To evaluate the clinical efficacy of interferon injection therapy for common warts on the hands and feet and to analyze its associated adverse reactions. METHODS: A total of 326 patients with common warts located on the hands and feet who were treated at our hospital between January 2024 and February 2025 were enrolled. Using a block randomization method, the patients were divided into a control group (n = 163, treated with cryotherapy) and an observation group (n = 163, treated with intralesional interf…
Rank95.5
Effectiveness of acceptance and commitment therapy on sexual function in women infected with human papillomavirus: a randomized controlled trial.
The journal of sexual medicine · 2026 · PMID 42447398
BACKGROUND: Human papillomavirus (HPV) is a prevalent sexually transmitted infection that negatively affects women's psychological, social, and sexual well-being worldwide. AIM: This study aimed to evaluate the effect of group Acceptance and Commitment Therapy (ACT) counseling on sexual function in women diagnosed with HPV infection. METHODS: This single-blind randomized clinical trial was conducted on 56 women with HPV infection. Participants were randomly assigned to an intervention group (n = 28) receiving 8 ses…
Rank89.9
De-Escalated Adjuvant Radiation Therapy in Patients With HPV-Positive Oropharyngeal Cancer.
JAMA network open · 2026 · PMID 42149594
IMPORTANCE: Standard adjuvant therapy for human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) is radiation therapy 60 Gy with or without cisplatin delivered in 30 fractions during 6 weeks. A phase 3 randomized clinical trial demonstrated decreased toxic effects and improved patient-reported outcomes with de-escalated adjuvant radiation therapy (DART) compared with standard therapy; however, outcomes for patients treated in the clinical practice setting following trial adoption remain u…
Rank88.8
Effectiveness of online supportive counselling on quality of life in women with high-risk human papillomavirus in Iran: study protocol for a randomised controlled trial.
BMJ open · 2026 · PMID 41692527
INTRODUCTION: Human papillomavirus (HPV) is one of the most common sexually transmitted diseases and affects the quality of life (QoL) of individuals, necessitating interventions beyond physical treatments. The aim of this study is to determine the effectiveness of individual supportive counselling on the QoL in women with high-risk HPV. METHODS AND ANALYSIS: This randomised clinical trial will include 80 women with HPV who will be selected from 2025 to 2026 in Babol, Iran. Following selection based on inclusion cr…
Rank85.0
Updates on Management of Anal Cancer: A New Era Has Begun.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2026 · PMID 42208017
Squamous cell carcinoma of the anal canal (SCAC) is a rare, human papillomavirus-driven malignancy with a rising global incidence and an increasingly dynamic therapeutic landscape. This review summarizes recent advances and current evidence in the management of SCAC, with a focus on immunotherapy, systemic treatment strategies, and optimization of curative-intent approaches. For locally advanced SCAC, concurrent chemoradiotherapy with fluorouracil and mitomycin C remains the standard of care, on the basis of multip…
Rank85.0
Technological innovations in head and neck radiotherapy: What does the future hold?
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2026 · PMID 42001737
Radiotherapy in head and neck oncology is advancing thanks to technologies that improve treatment precision, adaptation, and tolerance. The most promising approaches are discussed in this narrative review. The use of automatic segmentation through artificial intelligence (deep learning) now allows rapid delineation of organs at risk, thus reducing contouring time and the risk of errors. Several tools are already routinely used and are evaluated for replanning process. Imaging, acquired before each session, ensures …
Rank80.0
FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 41385605
PURPOSE: We conducted a phase II multicenter clinical trial to test the hypothesis that 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)-based chemoradiation (CRT) dose deescalation would provide noninferior locoregional control compared with historical controls among patients with early-stage p16+ oropharyngeal cancer. We also hypothesized that human papillomavirus (HPV) circulating tumor DNA (ctDNA) changes during treatment predict locoregional recurrence (LRR). PATIENTS AND METHODS: Patients with st…
Rank77.7
Clinical characteristics, treatment patterns, and prognosis in vulvar cancer and vaginal cancer: a national multicenter retrospective study in China.
BMC public health · 2026 · PMID 42032499
BACKGROUND: Vulvar and vaginal cancers significantly impact women’s health and quality of life. This study analyzes the prevalence of human papillomavirus (HPV), clinicopathological characteristics, treatment patterns, and survival outcomes, to understand their relationships and better guide prevention and therapy for Chinese patients with vulvar or vaginal cancer. METHODS: We conducted a retrospective, multicenter study across nine tertiary hospitals located in seven regions of China, including patients diagnosed …
Rank73.7
Long-term predictors of recurrence in pediatric recurrent respiratory papillomatosis.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 · PMID 42472951
PURPOSE: To identify predictors of recurrence in pediatric recurrent respiratory papillomatosis (RRP) using a 10-year prospective cohort, evaluating traditional factors (HPV type, lesion characteristics) and novel patient- and disease-specific variables, and their association with Speech-Quality-of-Life (SQOL). METHODS: We conducted a multicenter, prospective cohort study of 740 patients (629 pediatric, 111 adult) with histologically confirmed RRP from 2014 to 2023 at five high-volume ENT centers in Pakistan. The p…
Rank69.9
Concordance and acceptability of a novel human papillomavirus self-collection tool for cervical cancer screening in economically developed regions: a prospective cohort study in Shanghai, China.
Frontiers in medicine · 2026 · PMID 41868217
BACKGROUND: This study aimed to evaluate the concordance and clinical applicability of a novel cervical self-sampling device for human papillomavirus (HPV) genotyping, and to identify factors influencing women's preference for self-collection in an economically developed setting. METHODS: In this prospective paired-sample study conducted at Shanghai East Hospital (September 2024-February 2025), 276 eligible women from gynecological outpatient clinics underwent sequential cervical sampling: self-collection followed …
Rank68.0
Results of a Phase 1 Open-Label, Dose-Escalation Study of Gene Therapy With AAV2-hAQP1 for Grade 2 and 3 Radiation-Induced Late Xerostomia and Parotid Gland Hypofunction.
International journal of radiation oncology, biology, physics · 2026 · PMID 42216935
PURPOSE: Grade 2 and 3 late xerostomia is a chronic, debilitating complication of radiation therapy for head and neck cancers. We assessed the safety and efficacy of AAV2-hAQP1 gene therapy as a treatment for this condition. METHODS AND MATERIALS: Twenty-four participants who reported grade 2 and 3 late xerostomia at screening, ≥5 years after completing their final radiation therapy treatment (≥2 years if human papillomavirus-positive), were enrolled in this open-label, multicenter, dose-escalation study. AAV2-hAQP…
Rank53.2
Chemotherapy plus camrelizumab for fertility preservation (NACI-F) in FIGO stage IB1 cervical cancer: a multicenter, single-arm, phase 2 trial.
Journal of gynecologic oncology · 2026 · PMID 42172490
BACKGROUND: The increasing prevalence of cervical cancer in younger women highlights the need for personalized fertility-preserving treatment strategies. Current fertility preservation approaches for early-stage cervical cancer primarily involve cervical conization and radical trachelectomy. However, removing part or all of the cervix can negatively impact reproductive outcomes. These procedures increase the risk of preterm birth and miscarriage, and sometimes require additional surgery due to positive margins. Com…
Rank51.3
Early toxicity prediction using longitudinal cone-beam CT delta-radiomics in HPV-positive oropharyngeal cancer.
Frontiers in oncology · 2026 · PMID 42255209
INTRODUCTION: Long-term survival in human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has shifted clinical focus toward minimizing treatment-related toxicities, particularly dysphagia, which significantly impacts quality of life. This study investigated whether longitudinal cone-beam computed tomography (CBCT)-based delta-radiomics of the supraglottic region can provide early indication of 6-12 month post-radiotherapy dysphagia. METHODS: Forty-three patients with HPV+ OPSCC treated …
Rank50.7
Mapping the Evolving Trend and Prospect of Transoral Robotic Surgery: A Bibliometric Analysis.
The Journal of craniofacial surgery · 2026 · PMID 41129207
OBJECTIVES: To conduct a comprehensive bibliometric analysis elucidating the global research landscape, collaborative networks, and evolving hotspots in transoral robotic surgery (TORS) from 2005 to 2024. MATERIALS AND METHODS: Publications related to TORS were retrieved from the Web of Science Core Collection database (2005-2024). In addition, the keyword "oropharyngeal cancer" was added to explore research hotspots. The data were primarily analyzed using bibliometric software based on publication date, country, a…
Rank50.5
Dosimetric Results for Organs at Risk From Radiation Therapy Dose De-Escalation to the Subclinical Region in Human Papillomavirus-Associated Oropharyngeal Cancer: A Propensity Score-Matched Analysis.
International journal of radiation oncology, biology, physics · 2026 · PMID 41985762
PURPOSE: The impact of radiation therapy (RT) dose de-escalation on organs at risk (OARs) for human papillomavirus-associated oropharyngeal cancer (OPC) is not known. This study retrospectively assessed OAR dosimetric outcomes of de-escalated RT for OPC. METHODS AND MATERIALS: We conducted a retrospective analysis of dosimetric data for patients with T1 to 4, N0 to 3 human papillomavirus-associated OPC treated with intensity modulated RT at a single academic institution between August, 2014 and January, 2023. All p…
Rank50.2
The effect of human genital warts virus on the quality of women's sexual life: A look at the effective factors.
Journal of education and health promotion · 2026 · PMID 42016412
BACKGROUND: The global prevalence of HPV is rising. Despite numerous studies on its effects on psychological dimensions, quality of life, and sexual performance, its impact on women's sexual quality of life (QoL) remains unclear. This study assesses the sexual QoL among women with genital HPV and the influencing factors. MATERIALS AND METHODS: A cross-sectional study was conducted on 395 women undergoing HPV testing. The data collection instrument comprised a questionnaire covering demographic characteristics, HPV-…
Rank50.0
5-ALA-PDT combined with oral Kangfuxin solution improves HR-HPV outcomes, vaginal microecology and quality of life in patients with HPV-positive cervical erosion.
American journal of translational research · 2026 · PMID 42007140
OBJECTIVE: To evaluate the efficacy, safety, and effects on related indicators of 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) combined with oral Kangfuxin liquid in patients with human papillomavirus (HPV)-positive cervical erosion. METHODS: Patients admitted retrospectively from January 2022 to December 2024 were included. A total of 314 patients were initially screened, and 32 were excluded, leaving an original cohort of 282 patients (129 in the observation group and 153 in the control group).…
Rank49.9
Systemic Comorbidities of Keloid and Hypertrophic Scars: A Phenome-Wide Association Study in a Multiethnic U.S. Pediatric Cohort.
American journal of clinical dermatology · 2026 · PMID 42543465
BACKGROUND: Excessive scarring (ES), including keloids and hypertrophic scars, impairs function, appearance, and quality of life in children. Its pediatric comorbidity spectrum is not well defined, limiting anticipatory guidance and multidisciplinary care. This research aims to investigate comorbidities of ES in a diverse pediatric cohort using a phenome-wide association study (PheWAS). METHODS: This population-based study leveraged longitudinal electronic health record (EHR) data from participants enrolled in the …
Rank49.4
Effects of HPV-related psychosocial burden and general psychological health on quality of life and sexual function in women with HPV infection in the initial period after diagnosis.
BJPsych open · 2026 · PMID 41621815
BACKGROUND: Human papillomavirus (HPV) infection has a negative impact on quality of life (QoL) and sexual function, mainly owing to increased levels of anxiety and distress. AIMS: To examine the potentially moderating effects of general psychological health on the relationships between (a) HPV-related psychosocial burden and QoL and (b) HPV-related psychosocial burden and sexual function. METHOD: The HPV Impact Profile, Female Sexual Function Index, General Health Questionnaire-28 and Life Satisfaction Inventory q…
Rank49.4
HPV and Health-related Quality of Life Scale: Turkish validity and reliability study.
BMC women's health · 2026 · PMID 42121152
OBJECTIVE: This study aims to adapt the HPV and Health-Related Quality of Life Scale (HPV-RQOLS) into Turkish and evaluate its reliability and validity. METHODS: This methodological study employed a cross-sectional design and convenience sampling. A total of 150 women diagnosed with HPV who presented to a training and research hospital in Turkey between January and December 2023 were included. The inclusion criteria were age between 18 and 60 years, proficiency in Turkish, a confirmed HPV-positive diagnosis, and vo…
Rank49.3
The most influential factors in the psychological impact of an abnormal cervical screening result: A cross-sectional study.
Health psychology open · 2026 · PMID 41835031
To identify factors associated with higher levels of anxiety and poorer quality of life in women with abnormal results in a cervical screening programme. A cross-sectional study was conducted among 140 women aged 25-65 years with abnormal cervical screening results referred to the Cervical Pathology Clinic at Donostia University Hospital between May and November 2022. Anxiety and quality of life were assessed using the State-Trait Anxiety Inventory (STAI) and the Human Papillomavirus-related Quality of Life (HPV-Qo…
Randomized Controlled Trials83 records
Rank113.0
2024 recommendations for the therapeutic management of anogenital warts.
Annales de dermatologie et de venereologie · 2026 · PMID 42235479
INTRODUCTION: Anogenital warts (AGW) are benign epithelial skin lesions caused mainly by the human papillomavirus (HPV, types 6 and 11) but are sometimes associated with other oncogenic HPV types. They have a high rate of post-treatment recurrence. There are many guidelines, but they do not prioritise treatments. Therapeutics are classified as either self-administered or clinician applied. The aim of this study was to propose recommendations for the management of AGW. METHOD: These recommendations were based on a s…
Rank108.7
Human papillomavirus (HPV) vaccination in women with conisation.
The Cochrane database of systematic reviews · 2025 · PMID 40919695
RATIONALE: Cervical cancer is the fourth most common cancer affecting women worldwide, caused by persistent infection with oncogenic human papillomavirus (HPV) types. While HPV infections usually resolve spontaneously, persistent infections with high-risk HPV types can progress to premalignant glandular or - mostly - squamous intraepithelial lesions, usually classified in cervical intraepithelial neoplasia (CIN). Women with CIN 2 and CIN 3 (i.e. high-grade CIN) typically undergo cervical conisation to remove precan…
Rank107.8
HPV circulating tumor DNA as a potential prognostic and predictive biomarker in head and neck squamous cell carcinoma: a systematic review.
Oral oncology · 2026 · PMID 42641201
PURPOSE: Human papillomavirus circulating tumor DNA (HPVctDNA) has emerged as a promising prognostic biomarker in HPV-related head and neck squamous cell carcinoma (HNSCC). This systematic review aimed to synthesize current evidence on the diagnostic accuracy and prognostic value of HPVctDNA in HNSCC management. MATERIAL/METHODS: We systematically reviewed a PubMed-indexed database of studies published between January 2012 and September 2025. Eligible studies were assessed for design, primary tumor site and stage, …
Rank107.1
Subsequent-line Systemic Therapy for Metastatic or Recurrent Penile Cancer: A Systematic Review of Efficacy, Toxicity, and Outcomes.
European urology focus · 2026 · PMID 41519649
BACKGROUND AND OBJECTIVE: Treatment options for metastatic or recurrent penile squamous cell carcinoma (PSCC) progressing after first-line platinum-based chemotherapy are limited, and no standard subsequent-line systemic therapy exists. We systematically reviewed the efficacy, safety, and survival outcomes of second- and later-line systemic treatments in this setting. METHODS: A systematic review, compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, was performed across …
Rank106.0
A meta-analysis of photodynamic therapy in the treatment of cervical intraepithelial neoplasia: Based on randomized controlled trials.
Photodiagnosis and photodynamic therapy · 2026 · PMID 41740824
OBJECTIVE: To systematically evaluate the efficacy and safety of photodynamic therapy (PDT) for HPV-infected cervical intraepithelial neoplasia (CIN) based on randomized controlled trials (RCTs). METHODS: A systematic search was performed across PubMed, EMBASE, Web of Science, and the Cochrane Library from 2000 to 2025, targeting RCTs that compared PDT with standard conization methods or placebo. The primary outcomes assessed included histopathological response, human papillomavirus (HPV) clearance, and the rate of…
Rank105.8
Transoral robotic surgery versus definitive (Chemo)radiotherapy in early HPV-positive oropharyngeal cancer: A systematic review and meta-analysis of oncologic outcomes.
Oral oncology · 2026 · PMID 41806530
INTRODUCTION: Although individual studies suggest similar oncologic outcomes between transoral robotic surgery (TORS) and definitive (chemo)radiotherapy (RT/CRT) for early-stage human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC), oncologic and functional outcomes have not been systematically synthesized. OBJECTIVE: To compare oncologic and functional outcomes of a primary surgery-based strategy versus a primary definitive RT/CRT strategy in early-stage HPV-OPSCC. METHODS: PubMed, Embase…
Rank105.7
Global prevalence of cervical human papillomavirus in women aged 50 years and older with normal cytology: a systematic review and meta-analysis.
The Lancet. Microbe · 2025 · PMID 39622259
BACKGROUND: Given the paucity of up-to-date empirical data on human papillomavirus (HPV) among older women, we aimed to estimate the global HPV prevalence in women aged 50 years and older with normal cytology. METHODS: In this systematic review and meta-analysis, we searched for quantitative studies (cross-sectional, longitudinal, case-control, randomised control trials) reporting HPV prevalence among women aged 50 years and older with normal cytology published until May 31, 2022, in PubMed, Scopus, and Web of Scie…
Rank105.1
Surgical and Voice Outcomes of Office-Based Recurrent Respiratory Papillomatosis Surgery: A Systematic Review.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026 · PMID 41848235
OBJECTIVE: To investigate the surgical and voice outcomes associated with office-based laryngeal surgery for the treatment of recurrent respiratory papillomatosis (RRP). DATA SOURCES: PubMed, Google Scholar, and Cochrane databases. REVIEW METHODS: Two independent investigators search databases for studies reporting surgical or voice quality outcomes of patients treated with office-based surgery for RRP according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Primary o…
Rank102.0
Efficacy and safety of superficial radiotherapy in the treatment of cutaneous warts: A meta-analysis.
The Journal of international medical research · 2026 · PMID 42333510
ObjectiveTo systematically evaluate clinical evidence concerning the efficacy and safety of superficial radiotherapy in the treatment of cutaneous warts.MethodsEight major international clinical literature databases were queried according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for superficial radiotherapy studies published prior to 9 August 2025. Randomized controlled trials, prospective/retrospective controlled studies, and case series with sample sizes ≥10 we…
Rank101.5
[Efficacy and safety of hexaminolevulinate photodynamic therapy for CIN2].
Zhonghua fu chan ke za zhi · 2026 · PMID 42706058
Objective: To evaluate the efficacy and safety of hexaminolevulinate photodynamic therapy (HAL-PDT) for the treatment of cervical intraepithelial neoplasia 2 (CIN2). Methods: Data of this study were derived from an international multicenter, randomized, double-blind, placebo-controlled phase Ⅲ clinical trial (the APRICITY study) conducted between October 2020 and July 2023, with medical records obtained from 61 medical centers across 7 countries. A subgroup analysis was performed in patients with histologically con…
Rank100.7
Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial.
Scientific reports · 2026 · PMID 42215629
Alcohol consumption is recognized as a risk factor for oropharyngeal cancer. However, its role in oral human papillomavirus (HPV) infection among people living with HIV (PLWH) remains unclear. This cross-sectional study analyzed baseline data from 699 men living with HIV (MLWH) enrolled in the multicenter ULACNet-201 trial (NCT04255849) to assess oral HPV infection by drinking behavior, examine the association between alcohol consumption and HPV infection, exploring smoking as a potential effect modifier. Oral garg…
Rank100.6
Comparison of three different hpv self-sampling tools - a subanalysis of the prospective, randomized hannover self-collection study.
Archives of gynecology and obstetrics · 2026 · PMID 42347973
OBJECTIVE: Cervical cancer and its precursor lesions are treatable if detected early; however, screening participation for high-risk human papillomavirus infections (hr-HPV) remains low. In 2021, Germany recorded 4,544 new cervical cancer cases and 2,071 related deaths. The HaSCo study evaluates the feasibility of HPV self-testing to improve screening participation. This sub-study evaluates performance and acceptability of three self-testing tools. METHODS: This prospective, randomized sub-study examined Evalyn-Bru…
Rank100.4
Immunogenicity and safety of co-administered Escherichia coli-produced bivalent HPV-16/18 vaccine and hepatitis E vaccine.
Frontiers in immunology · 2026 · PMID 42292449
BACKGROUND: Human papillomavirus (HPV) and Hepatitis E virus (HEV) infections are major health concerns for women of reproductive age. Administration of HPV and HEV vaccines serves as primary prevention strategies. Our study aimed to demonstrate the immunogenicity and safety of co-administering Escherichia coli-produced bivalent HPV-16/18 vaccine and HEV vaccine compared to HPV-alone/HEV-alone. METHODS: This randomized, multicenter, open-label trial was conducted at 4 clinical study sites in Zhejiang Province, Chin…
Rank100.0
Oncologic, functional, and economic outcomes of transoral robotic surgery for HPV-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of pathology and treatment strategies.
Journal of robotic surgery · 2026 · PMID 42162526
The incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has increased substantially. Transoral robotic surgery (TORS) provides detailed pathological assessment that may support risk-adapted treatment strategies; however, integrated evidence on oncologic, functional, and economic outcomes remains limited. To systematically evaluate oncologic, functional, and economic outcomes of TORS-based treatment strategies in patients with HPV-positive OPSCC. A systematic review and met…
Rank100.0
Maximizing impact: the power of early HPV vaccination for long-term protection-lessons from a systematic review and meta-regression analysis.
Journal of public health (Oxford, England) · 2026 · PMID 41612578
BACKGROUND: This systematic review and meta-regression analysis assessed the impact of human papillomavirus 16/18 (HPV16/18)-AS04 vaccine (Cervarix®) on advanced cervical lesions, including grade 3 cervical intraepithelial neoplasia or worse (CIN3, CIN3+), or cervical cancer, highlighting age-at-vaccination-dependent vaccine efficacy and effectiveness. METHODS: Studies reporting HPV16/18-AS04 vaccine efficacy or effectiveness were included with an intervention group receiving HPV16/18-AS04 vaccine and comparator gr…
Rank100.0
HPV vaccination efficacy in primary and tertiary prevention of vulvar and vaginal HPV-related high grade dysplasia and cancers: A systematic review.
Human vaccines & immunotherapeutics · 2025 · PMID 41158101
The impact of HPV vaccination on cervical cancer and condylomas is well-established, but its effectiveness against high grade vulvar and vaginal lesions (VIN/VaIN) and related cancers remains less clear due to their rarity. This systematic review assessed the efficacy of quadrivalent (qHPV) and 9-valent (9vHPV) vaccines in both primary and tertiary prevention of these conditions. Eleven studies met the inclusion criteria. qHPV showed 100% efficacy against HPV16/18-related VIN/VaIN and cancers in per-protocol popula…
Rank100.0
Immunogenicity, efficacy, and safety of different dose schedules of human papillomavirus vaccines: a Bayesian network meta-analysis of randomized controlled trials.
Frontiers in immunology · 2026 · PMID 42625665
BACKGROUND: To enhance global vaccine coverage and reduce costs, Human papillomavirus (HPV) immunization schedules are shifting from the standard three-dose (3D) regimen toward reduced-dose (1D or 2D) schedules. We aimed to evaluate the comparative immunogenicity, efficacy, and safety of diverse dose schedules and vaccine types using a Bayesian network meta-analysis. METHODS: Two reviewers independently searched PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI, and Wanfang Data from in…
Rank99.8
Comparing paclitaxel and platinum-based concurrent chemoradiotherapy with short-term adjuvant chemotherapy versus platinum-based monotherapy concurrent chemoradiotherapy in patients with postoperative gastric-type endocervical adenocarcinoma with high-risk factors for recurrence: a multicenter randomized phase III trial.
Journal of gynecologic oncology · 2026 · PMID 41834413
BACKGROUND: Gastric-type endocervical adenocarcinoma (G-EAC) is a distinctive form of adenocarcinoma that is not associated with human papillomavirus. This neoplasm exhibits a low incidence, low screening and biopsy positivity, low preoperative diagnosis, and a high susceptibility to underdiagnosis and misdiagnosis. It is associated with a poor prognosis for patients. Currently, there is an absence of a standardized postoperative adjuvant treatment plan for G-EAC, which constitutes an urgent clinical problem that d…
Rank99.6
HPV Testing Versus Cytology for Cervical Cancer Screening Among Women 50 Years and Older: Evidence From the HPV FOCAL Randomized Controlled Trial.
International journal of cancer · 2026 · PMID 42363777
Evidence on the comparative effectiveness of HPV testing versus cytology specifically in women aged ≥ 50 years who are approaching screening cessation remains limited. This analysis included 6471 women aged ≥ 50 at baseline screening in the HPV FOCAL randomized clinical trial. Women were randomly allocated to receive cytology (Control Group, n = 3248, 50.19%) or HPV testing (Intervention Group, n = 3223, 49.81%) at baseline, with co-testing at 48-month exit. We calculated incidence rates and risk ratios for CIN2+ d…
Rank98.9
An implementation study of text invitation, mailed at-home human papillomavirus (HPV) self-testing and telehealth management in Aotearoa New Zealand, with a nested randomised controlled trial that compared offering an incentive vs. no offer with a repeat test kit.
BMC public health · 2026 · PMID 42120989
INTRODUCTION: In Aotearoa New Zealand, human papillomavirus (HPV) self-testing was introduced simultaneously with HPV primary screening in September 2023 to improve access and reduce inequities for priority populations, including Indigenous Māori, Pacific and under-screened people. To contribute policy-relevant information, we implemented non-standard engagement and screening strategies, including text message invitation, mailed test kits, at-home self-testing, telehealth support and follow-up by a central nurse-le…
Rank98.5
Immunogenicity and safety of a quadrivalent recombinant human papillomavirus vaccine (type 6/11/16/18) (Hansenula polymorpha): A randomized controlled phase 2 non-inferiority clinical trial.
Vaccine · 2026 · PMID 41932289
OBJECTIVE: The randomized, double-blind, placebo-controlled Phase II non-inferiority clinical study aimed to evaluate the immunogenicity and safety of the quadrivalent recombinant human papillomavirus vaccine (type 6/11/16/18) (Hansenula polymorpha) in healthy females aged 9-45 years. METHODS: A total of 1800 participants were randomly assigned to the vaccine group and the placebo group in a 2:1 ratio. The immunobridging between the 9-17 and 18-45 age groups adopts a non-inferiority design with a non-inferiority ma…
Rank98.2
Large Language Model Chatbot Conversations vs Public Health Materials and Parental HPV Vaccination Intentions: A Randomized Clinical Trial.
JAMA network open · 2026 · PMID 42258213
IMPORTANCE: Health care systems are increasingly considering large language model (LLM)-based chatbots for vaccine communication, but evidence that they improve durable, behaviorally relevant outcomes beyond existing health materials is limited. OBJECTIVES: To examine whether brief, multiturn interactions with an LLM chatbot increase parental intention to vaccinate children against human papillomavirus (HPV) compared with no intervention and government public health materials and to assess whether any effects persi…
Rank98.0
International Papillomavirus Society statement on reputed treatments for human papillomavirus infection and human papillomavirus-related diseases: evidence, risks, and standards for clinical evaluation.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026 · PMID 42680631
Human papillomavirus is the most common sexually transmitted infection and the necessary cause of cervical cancer, as well as a proportion of other anogenital and oropharyngeal cancers. Although most infections clear spontaneously, persistent oncogenic human papillomavirus infection may lead to precancer and cancer. There is therefore a need for effective and globally accessible therapies that either promote sustained clearance of human papillomavirus infection or safely treat human papillomavirus-related lesions, …
Rank97.7
Genotype distribution of human papillomavirus (HPV) types in oral gargle specimens among men living with HIV in Mexico, Brazil, and Puerto Rico: A cross-sectional study.
The Journal of infection · 2026 · PMID 42070588
OBJECTIVES: Assess the distribution of oral HPV genotypes and examine their associations with age and HIV-related factors among men living with HIV. METHODS: This cross-sectional study analyzed baseline data from a randomized, double-blinded, placebo-controlled Phase III trial ('ULACNet-201'; NCT04255849) assessing the 9vHPV vaccine's efficacy in PLWH. Participants included men aged 20-50 years from Brazil, Mexico, and Puerto Rico, on antiretroviral therapy for ≥6 months. Oral HPV genotypes were assessed using the …
Rank97.7
Immunogenicity and safety of Papilloguard® 4, the first quadrivalent HPV vaccine combined with adjuvant system 04, versus Gardasil® in healthy 15-25-year-old individuals: a phase III, randomized, double-blind, non-inferiority trial.
Vaccine · 2026 · PMID 42424856
OBJECTIVE: Papilloguard® is developed by Nivad Pharmed Salamat as a quadrivalent human papillomavirus (HPV) vaccine, uniquely combined with the adjuvant system 04 (AS04). The objective of this study was to evaluate the immunogenicity and safety of the quadrivalent Papilloguard® in comparison with Gardasil® (Merck). METHODS: This study enrolled 670 healthy participants aged 15-25 years. Vaccines were administered at Months 0, 2, and 6. Immunogenicity was assessed by geometric mean concentrations of HPV-specific anti…
Safety And Adverse Effects88 records
Rank108.3
Immunogenicity and safety of prophylactic HPV vaccines in people living with HIV: A systematic review and meta-analysis.
Human vaccines & immunotherapeutics · 2026 · PMID 42684271
Human papillomavirus (HPV) is a major global public health concern, causing genital warts and cancers of the cervix, anus, oropharynx, vulva, and penis. People living with HIV (PLWH) face a disproportionately elevated burden of HPV infection and HPV-related malignancies due to chronic immunosuppression. We conducted a systematic review and meta-analysis searching six databases from January 2006 to June 2026 without language restrictions. Twenty-five studies were included in the systematic review; 12 independent stu…
Rank106.4
De-Escalation Treatment Strategies in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An Umbrella Review of Systematic Reviews and Meta-Analyses.
Head & neck · 2026 · PMID 42230323
BACKGROUND: De-escalation strategies for human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) aim to reduce late morbidity while preserving cure rates, but evidence syntheses provide inconsistent conclusions and may be affected by overlap of primary studies. METHODS: We performed an umbrella review of systematic reviews (SRs) and meta-analyses (MAs) evaluating de-escalation approaches versus standard-of-care therapy in HPV-positive (or p16-positive) OPSCC. MEDLINE (PubMed), Embase, and …
Rank103.6
Anal High-Grade Squamous Intraepithelial Lesions in People Living with HIV: A Systematic Review of Treatment Outcomes.
Cancers · 2026 · PMID 42649891
Background/Objectives: People living with HIV (PLWH) are at substantially increased risk of anal high-grade squamous intraepithelial lesions (HSIL), a recognized precursor of anal cancer. Although the ANCHOR trial demonstrated that treatment reduces progression to invasive disease, important uncertainties remain regarding durability of response, recurrence patterns, and treatment-related toxicity across available therapeutic strategies. Methods: We conducted a systematic review of studies evaluating treatment outco…
Rank103.0
Artificial intelligence in cervical cancer screening and triage: a role-stratified systematic review and bivariate meta-analysis.
Current opinion in oncology · 2026 · PMID 42343867
PURPOSE OF REVIEW: Artificial intelligence (AI) tools for cervical cancer screening have proliferated, but modality-pooled accuracy estimates conflate clinically distinct uses of AI. We re-examine this evidence base through a role-stratified bivariate meta-analysis to clarify where AI is ready for clinical translation and where gaps remain. RECENT FINDINGS: Of 97 eligible studies published between 2019 and 2026, 47 with reconstructible 2 × 2 data were pooled using a bivariate Reitsma model stratified by clinical ro…
Rank100.7
Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial.
Scientific reports · 2026 · PMID 42215629
Alcohol consumption is recognized as a risk factor for oropharyngeal cancer. However, its role in oral human papillomavirus (HPV) infection among people living with HIV (PLWH) remains unclear. This cross-sectional study analyzed baseline data from 699 men living with HIV (MLWH) enrolled in the multicenter ULACNet-201 trial (NCT04255849) to assess oral HPV infection by drinking behavior, examine the association between alcohol consumption and HPV infection, exploring smoking as a potential effect modifier. Oral garg…
Rank100.0
Immunogenicity, efficacy, and safety of different dose schedules of human papillomavirus vaccines: a Bayesian network meta-analysis of randomized controlled trials.
Frontiers in immunology · 2026 · PMID 42625665
BACKGROUND: To enhance global vaccine coverage and reduce costs, Human papillomavirus (HPV) immunization schedules are shifting from the standard three-dose (3D) regimen toward reduced-dose (1D or 2D) schedules. We aimed to evaluate the comparative immunogenicity, efficacy, and safety of diverse dose schedules and vaccine types using a Bayesian network meta-analysis. METHODS: Two reviewers independently searched PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI, and Wanfang Data from in…
Rank100.0
Intralesional human papillomavirus vaccination for cutaneous verrucae: a systematic review and meta-analysis of therapeutic efficacy.
The Journal of dermatological treatment · 2026 · PMID 42370553
OBJECTIVES: To evaluate the efficacy of intralesional human papillomavirus (HPV) vaccination in the management of cutaneous warts. METHODS: A comprehensive search of PubMed, MEDLINE, Embase, Scopus, and ClinicalTrials.gov was conducted in accordance with a registered PROSPERO protocol (CRD420251170324). Chronic or persistent warts were defined as lesions lasting more than six months or showing inadequate response to conventional therapies. The primary outcome was complete wart clearance, and pooled risk ratios (RRs…
Rank100.0
Serious adverse events following human papillomavirus vaccination: A systematic review and meta-analysis of post-marketing evidence.
Human vaccines & immunotherapeutics · 2026 · PMID 41759030
Human papillomavirus (HPV) vaccines are a critical tool in cancer prevention, yet concerns about serious adverse events (SAEs) have fueled public hesitancy and constrained vaccination uptake. This systematic review aimed to determine the proportion of adverse events that were SAEs, rate of SAEs following HPV vaccination and their association from post-marketing observational studies. We conducted a search in PubMed, EMBASE, and Web of Science databases in March 2025. Studies published in English reporting SAEs afte…
Rank100.0
Update on completed and ongoing trials investigating TORS in head and neck oncology.
Frontiers in oncology · 2026 · PMID 42682574
BACKGROUND: Human papillomavirus (HPV) has substantially altered the epidemiology and prognosis of oropharyngeal squamous cell carcinomas (OPSCC), with an increasing incidence in younger patients and markedly improved survival outcomes. This shift presents an increasing clinical challenge: how to safely reduce treatment intensity, while maintaining cure and survival rates and minimizing therapy-related toxicity. Transoral robotic surgery (TORS) has emerged as a pivotal strategy in this context, with multiple clinic…
Rank100.0
Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review.
Human vaccines & immunotherapeutics · 2025 · PMID 40485552
Cervical cancer is a preventable disease for which vaccines are available to provide long-term protection against human papillomavirus (HPV) infection. This systematic literature review (SLR) was performed to summarize the efficacy, effectiveness, impact, duration of protection, and safety profile of four licensed HPV vaccines against infection, precursor lesions, and cervical cancer. Data was extracted from published reports. The search resulted in 1,136 studies, of which 54 were selected for this review. A substa…
Rank99.0
Efficacy and Safety of Systemic Bevacizumab in Children with Recurrent Respiratory Papillomatosis: A Systematic Review.
Journal of voice : official journal of the Voice Foundation · 2026 · PMID 42637636
OBJECTIVE: To systematically evaluate the efficacy and safety of systemic bevacizumab in children with JoRRP. METHODS: A systematic literature review was conducted according to the PRISMA 2020 guidelines. MEDLINE, Embase, ScienceDirect, and the Cochrane Library were searched from database inception to June 30, 2026. Studies reporting pediatric patients (<18 years) with JoRRP treated with intravenous bevacizumab were included. Data regarding patient characteristics, treatment protocols, clinical outcomes, and advers…
Rank97.7
Immunogenicity and safety of Papilloguard® 4, the first quadrivalent HPV vaccine combined with adjuvant system 04, versus Gardasil® in healthy 15-25-year-old individuals: a phase III, randomized, double-blind, non-inferiority trial.
Vaccine · 2026 · PMID 42424856
OBJECTIVE: Papilloguard® is developed by Nivad Pharmed Salamat as a quadrivalent human papillomavirus (HPV) vaccine, uniquely combined with the adjuvant system 04 (AS04). The objective of this study was to evaluate the immunogenicity and safety of the quadrivalent Papilloguard® in comparison with Gardasil® (Merck). METHODS: This study enrolled 670 healthy participants aged 15-25 years. Vaccines were administered at Months 0, 2, and 6. Immunogenicity was assessed by geometric mean concentrations of HPV-specific anti…
Rank97.6
Efficacy and safety of a topical nitric oxide-releasing solution (NORS) as a noninvasive treatment for plantar warts (verrucae plantaris).
The Journal of dermatological treatment · 2026 · PMID 41493215
BACKGROUND: Plantar warts (verrucae plantaris), caused by human papillomavirus, are common and often resistant to standard therapies, which can be painful and damaging. Novel, noninvasive options are needed. OBJECTIVE: To evaluate the safety and preliminary efficacy of a topical nitric oxide-releasing solution (NORS) as a self-administered therapy for plantar warts. METHODS: In this Phase 2a, multicenter, randomized, double-blind, placebo-controlled trial, 20 participants with ≥3 plantar warts were randomized (1:1:…
Rank97.1
Call for Increased Community Education Regarding Common HPV-Associated Cancers Within the Urban Safety-Net Hospital Population.
Journal of cancer education : the official journal of the American Association for Cancer Education · 2026 · PMID 40888851
While oropharyngeal and cervical cancer rates declined in the 1980s, incidence and mortality rates from both cancers have increased annually in the last two decades. The incidence of oropharyngeal cancer has now surpassed that of cervical cancer. A lack of knowledge about preventative measures and risk factors, including human papillomavirus [HPV] infection, may contribute to rising oropharyngeal cancer rates. This study examines patients' knowledge of oropharyngeal cancer and its relation to cervical cancer and HP…
Rank96.4
Immunogenicity and Safety of 2 Versus 3 Doses of 9-Valent Vaccine Against Human Papillomavirus in Women With Human Immunodeficiency Virus: The Papillon Randomized Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 40356381
BACKGROUND: The World Health Organization recommends 2 doses of human papillomavirus (HPV) vaccine for adults without human immunodeficiency virus (HIV) but 3 doses in persons with HIV. There are no immunogenicity data on the 2-dose schedule in women with HIV (WWH). METHODS: This was a prospective study comparing 2 doses (months 0 and 6) versus 3 (months 0, 2, and 6) doses of 9-valent vaccine (Gardasil 9, Merck Sharp & Dohme) in WWH (15-40 years), on antiretrovirals with HIV RNA <400 copies/mL, enrolled during 2018…
Rank96.0
What are the barriers and enablers to the uptake of the HPV vaccine in Romania, Bulgaria and Croatia? A mixed methods systematic review.
BMJ public health · 2026 · PMID 42689009
INTRODUCTION: Eradication of human papillomavirus (HPV) is a global public health priority. It is linked to approximately 5% of all cancers, causing almost all cases of cervical cancer, nearly 90% of anal cancers and a significant proportion of oropharyngeal, penile, vaginal and vulval cancers.HPV vaccination can provide protection when 90% coverage is reached. However, many countries are yet to achieve this threshold. Uptake in Romania, Bulgaria and Croatia has been low historically, and although rates are increas…
Rank96.0
Effectiveness of Electrocautery, Topical Cidofovir, and Topical Sinecatechins for the Treatment of Anal High-Grade Squamous Intraepithelial Lesions in Persons With HIV: An Open-Label, Randomized Controlled Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · PMID 40036375
BACKGROUND: Doubts remain about the best treatment for managing premalignant lesions (high-grade squamous intraepithelial lesions [HSIL]) associated with anal cancer. METHODS: The TREATAIN trial was an open-label, randomized study conducted at Hospital Vall d'Hebron (Spain). Persons with human immunodeficiency virus and anal HSIL were randomly assigned 1:1:1 to receive treatment with electrocautery, topical cidofovir 1% ointment, or topical sinecatechins 10%. The primary outcome was histological resolution of HSIL.…
Rank94.6
Long-term safety of human papillomavirus vaccination in relation to early pregnancy outcomes: registry-based follow-up of a community-randomized trial.
European journal of public health · 2026 · PMID 42586610
Despite the demonstrated safety of human papillomavirus vaccines, concerns have arisen regarding potential associations of human papillomavirus vaccination on reproductive health. The objective of this registry-based study was to compare overtime association of vaccination and early pregnancy outcomes. Twenty thousand four hundred twenty-six women born in 1992-1995, who participated in a Finnish community-randomized human papillomavirus vaccination trial, and age- and community-aligned unvaccinated controls born in…
Rank92.0
Assessment and Comparison of Efficacy and Safety of Monotherapy With Topical 50% Urea Cream and Combination Therapy With Topical 50% Urea Cream and Carboxytherapy in Treatment of Recalcitrant Common Wart: A Randomized, Single-Blinded, 2-Split Clinical Trial.
Journal of medical virology · 2026 · PMID 42541394
The treatment of common warts can occasionally be a challenge in recalcitrant cases, either recurrent ones or non-responders to treatment. In the current study, the efficacy and safety of monotherapy with topical 50% urea cream and combination therapy with topical 50% urea cream and carboxytherapy were assessed and compared in the treatment of recalcitrant common wart. Twenty subjects with recalcitrant common warts in the extremities (excluding the plantar surface) were selected. For the lesions of one side of the …
Rank91.5
Loop electrosurgical excision procedure and perinatal outcomes post-human papillomavirus cervical screening: A longitudinal cohort study.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026 · PMID 41709079
OBJECTIVE: This study examines the associations between the loop electrosurgical excision procedure (LEEP) and the risk of adverse perinatal outcomes among women who have undergone primary human papillomavirus (HPV) screening. METHODS: In this longitudinal cohort study, women who received HPV screening and were followed up in a randomized trial in British Columbia (BC), Canada, were linked to a province-wide perinatal registry; those with a singleton live birth after screening (index birth) were included (N = 1765)…
Rank91.0
Efficacy, immunogenicity, and safety of the 9-valent human papillomavirus vaccine in males aged 16-26 years in Japan: a randomised, double-blind, placebo-controlled trial.
The Lancet. Infectious diseases · 2026 · PMID 42546724
BACKGROUND: Efficacy of the nine-valent human papillomavirus (9vHPV; HPV6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine was shown in females and inferred for males through immunobridging. We evaluated the efficacy of the 9vHPV vaccine in males aged 16-26 years. METHODS: This randomised, double-blind, placebo-controlled, efficacy, immunogenicity, and safety phase 3 trial was conducted at 22 clinical research, hospital, medical, or treatment sites in Japan, with masking of investigators, sponsor personnel, and partici…
Rank89.8
Silicon dioxide vaginal gel and short-term high-risk human papillomavirus DNA detectability: A randomized controlled trial.
Acta obstetricia et gynecologica Scandinavica · 2026 · PMID 42557865
INTRODUCTION: Intravaginal products, including silicon dioxide-based gels, are marketed to support short-term high-risk human papillomavirus (hrHPV) clearance or loss of detectability, but independent randomized evidence testing these short-term claims against observation is limited. We evaluated whether daily intravaginal silicon dioxide-based gel treatment increases the proportion of women with no detectable cervical hrHPV DNA compared with observation alone. MATERIAL AND METHODS: This prospective, single-center,…
Rank89.8
Barriers to cervical cancer screening and experiences using mailed at-home HPV self-collection kits among US and foreign-born Hispanic women in a safety net health system.
Gynecologic oncology · 2026 · PMID 42468446
OBJECTIVE: Mailed self-collection for human papillomavirus (HPV) testing can increase cervical cancer screening among underscreened women, though barriers differ by subgroup. Hispanic/Latina women, especially foreign-born, have lower screening rates than non-Hispanic white women. This study compared barriers to Papanicolaou (Pap) screening and experiences with mailed HPV self-collection among underscreened foreign-born Hispanic, US-born Hispanic, and US-born non-Hispanic women in a safety-net health system. METHODS…
Rank85.0
Linking clinical trial data with real-world data for enhanced clinical evidence generation: methodological considerations and recommendations.
Frontiers in pharmacology · 2026 · PMID 42630489
Randomized controlled trials (RCTs) remain the cornerstone of causal inference on the safety and efficacy of medicinal products. But their limited follow-up, controlled settings, and narrowly defined data collection to balance the burden to patients and maintain study feasibility often results in unaddressed important questions for health authorities and other clinical decision makers. Linkage of RCT data to routinely collected health data [real-world data (RWD)] offers a mechanism for addressing these gaps by exte…
Rank85.0
Evaluation of the ESMO-magnitude of clinical benefit scale version 2.0 for the definitive treatment of HPV positive oropharynx cancer with radiation therapy.
Oral oncology · 2026 · PMID 42229021
BACKGROUND: The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a validated tool for assessing the clinical benefit of systemic cancer therapies. However, application of the scale to radiotherapy (RT) remains limited. As part of an ongoing initiative to adapt the scale for RT, we applied Form 1a of ESMO-MCBS v2.0 to studies cited in the American Society for Radiation Oncology (ASTRO) guideline for Human Papillomavirus (HPV)-positive oropharyngeal cancer (OPC) to assess feasi…
Treatments That Failed Clinical Trials60 records
Rank99.9
Design and initial findings of a natural history study of anal HPV and associated lesions among young adult women in Costa Rica.
International journal of cancer · 2025 · PMID 40815549
Anal cancer is caused by HPV, and its incidence has increased globally over the last five decades. We conducted an anal HPV natural history study nested in the Costa Rica HPV Vaccine Trial (CVT) to quantitatively describe the natural history and clinical outcomes of anal HPV in HIV-negative women. CVT was a randomized clinical trial of the bivalent HPV vaccine, and an anal substudy included women selected based on a priori criteria to enrich for anal disease. For women in the anal substudy, anal samples were collec…
Rank99.8
Ripple effect of temporary self-sampling HPV test on screening uptake in the next round: A secondary analysis of the ACCESS randomized controlled trial.
Journal of medical screening · 2026 · PMID 40567147
The self-sampling human papillomavirus (HPV) test improves participation in cervical cancer screening. However, the ripple effect of this test on participation in the next screening round has not yet been examined. This study, a secondary analysis of the Accelerating Cervical Cancer Elimination by Self-Sampling test (ACCESS) trial, aims to clarify this effect. Women who had not participated in the cervical cancer screening program of Ichihara City for 3 years or more were included. The participants were randomly as…
Rank99.6
HPV Testing Versus Cytology for Cervical Cancer Screening Among Women 50 Years and Older: Evidence From the HPV FOCAL Randomized Controlled Trial.
International journal of cancer · 2026 · PMID 42363777
Evidence on the comparative effectiveness of HPV testing versus cytology specifically in women aged ≥ 50 years who are approaching screening cessation remains limited. This analysis included 6471 women aged ≥ 50 at baseline screening in the HPV FOCAL randomized clinical trial. Women were randomly allocated to receive cytology (Control Group, n = 3248, 50.19%) or HPV testing (Intervention Group, n = 3223, 49.81%) at baseline, with co-testing at 48-month exit. We calculated incidence rates and risk ratios for CIN2+ d…
Rank99.5
Randomized Controlled Trial of Impact of Mobile Health Technologies on Human Papillomavirus Vaccination Uptake in Mothers of Vaccine-Eligible Girls in Lagos, Nigeria (mHealth-HPVac).
JCO global oncology · 2025 · PMID 40924973
PURPOSE: Expanding high-risk human papillomavirus (HPV) vaccine coverage in resource-constrained settings is critical to bridging the cervical cancer gap and achieving the global action plan for elimination. Mobile health (mHealth) technology via short message services (SMS) has the potential to improve HPV vaccination uptake. The mHealth-HPVac study evaluated the effectiveness of mHealth interventions in increasing HPV vaccine uptake among mothers of unvaccinated girls aged 9-14 years in Lagos, Nigeria. METHODS: A…
Rank98.7
The importance of spontaneous thought in the willingness to receive the human papillomavirus vaccine.
Vaccine · 2025 · PMID 40712321
After briefly suspending the 2-valent human papillomavirus (HPV) vaccine in 2013, Japan's Ministry of Health, Labour, and Welfare (MHLW) reinstated the recommendation that people receive the newly approved and updated 9-valent HPV vaccine in 2022. We investigated the influence of anticipated regret (AR) and spontaneous thought on individuals' willingness to receive the HPV vaccine, as the 2013 controversy over the HPV vaccine's side effects could lead to public distrust, impeding vaccination coverage despite govern…
Rank98.6
Induction Nivolumab Before Chemoradiation in High-Risk Human Papillomavirus-Driven Oropharynx Cancers: IMMUNEBOOST-HPV, a Multicenter Randomized Phase II Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 41570275
PURPOSE: Patients with human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) and advanced stage and/or significant smoking history are at higher risk of relapse. Induction immunotherapy before chemoradiation (CRT) may improve outcomes. This randomized phase II trial assessed the feasibility and safety of induction nivolumab before CRT in this high-risk population. METHODS: Eligible patients had HPV-positive OPC with either T4 and/or N2/N3 disease or a smoking history >10 pack-years. Patients were randomly …
Rank97.7
Genotype distribution of human papillomavirus (HPV) types in oral gargle specimens among men living with HIV in Mexico, Brazil, and Puerto Rico: A cross-sectional study.
The Journal of infection · 2026 · PMID 42070588
OBJECTIVES: Assess the distribution of oral HPV genotypes and examine their associations with age and HIV-related factors among men living with HIV. METHODS: This cross-sectional study analyzed baseline data from a randomized, double-blinded, placebo-controlled Phase III trial ('ULACNet-201'; NCT04255849) assessing the 9vHPV vaccine's efficacy in PLWH. Participants included men aged 20-50 years from Brazil, Mexico, and Puerto Rico, on antiretroviral therapy for ≥6 months. Oral HPV genotypes were assessed using the …
Rank97.7
Postoperative Radiotherapy ± Cetuximab for Intermediate-Risk Head and Neck Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025 · PMID 39841939
PURPOSE: Radiotherapy (RT)/cetuximab (C) demonstrated superiority over RT alone for locally advanced squamous head and neck cancer. We tested this in completely resected, intermediate-risk cancer. METHODS: Patients had squamous cell carcinoma of the head and neck (SCCHN) of the oral cavity, oropharynx, or larynx, with one or more risk factors warranting postoperative RT. Patients were randomly assigned 1:1 to intensity-modulated RT (60-66 Gy) with once-per-week C or RT alone. The primary hypothesis was that RT + C …
Rank97.3
A multicentre pragmatic randomized controlled trial comparing 50% salicylic acid, liquid nitrogen, 5% 5-fluorouracil cream, and 5% imiquimod cream in previously treated plantar warts. The VRAIE (VeRrues plAntaIres en villE) study.
Annales de dermatologie et de venereologie · 2025 · PMID 40743833
BACKGROUND: Plantar warts are common among the general population. After failure of first-line treatment, they are challenging to treat. OBJECTIVES: To compare 4 second-line treatments - 50 % salicylic acid ointment (SA) under occlusion, liquid nitrogen, 5 % 5-fluorouracil (5-FU) cream under occlusion, and 5 % imiquimod cream - in terms of complete remission after 90 days. METHODS: A multicentre, pragmatic, randomized, controlled trial. Screened patients with plantar warts were initially treated with a 5-week regim…
Rank97.2
A prospective study of vaginal topical pretreatment of compound sea-buckthorn oil suppository in postmenopausal women prior to colposcopy.
Scientific reports · 2025 · PMID 40133564
Postmenopausal women are faced with difficulties in colposcopy, such as easy bleeding from epithelial atrophy, and thinning, atypical colposcopy images, unsatisfactory exposure, and decreased sensitivity of colposcopy. We aimed to improve the sensitivity and satisfaction of colposcopy in postmenopausal women and to evaluate the clinical efficacy of compound sea-buckthorn oil suppository on topical vaginal pretreatment in postmenopausal women prior to colposcopy. Postmenopausal patients who underwent colposcopy in t…
Rank97.2
Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial.
JAMA · 2025 · PMID 40079944
IMPORTANCE: Treating locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) involves any combination of surgery, radiation, and chemotherapy, followed by routine monitoring for local recurrence or distant metastases. Given the poor patient outcomes, a significant unmet clinical need for improved treatment options remains. OBJECTIVE: To evaluate efficacy and safety of maintenance atezolizumab in patients with LA SCCHN at high risk of disease progression after multimodal definitive treatment. DESIGN…
Rank97.1
Self-Perceived Hearing Outcomes With Radiation and Cisplatin or Radiation and Cetuximab for Patients With Human Papilloma Virus (HPV)-Positive Oropharyngeal Cancer-Results From NRG Oncology RTOG 1016.
International journal of radiation oncology, biology, physics · 2026 · PMID 40829719
PURPOSE: RTOG 1016 was a noninferiority phase III trial comparing the efficacy of radiation with either cisplatin (RT + Cis) or cetuximab (RT + Cetux) for patients with Humman Papillomavirus (HPV)+ oropharyngeal cancer (OPC). Perceived hearing handicap was included as a patient-reported outcome (PRO) secondary endpoint. The primary hypothesis was that perceived hearing handicap would be greater for patients receiving RT + Cis compared with RT + Cetux. METHODS AND MATERIALS: Perceived hearing handicap was measured a…
Rank97.0
HPVoice: a single-blind three-arm RCT on social media communication strategies among adolescents in Tuscany, Italy.
Vaccine · 2026 · PMID 41855647
INTRODUCTION: Cervical cancer is the first cancer potentially eliminable through widespread HPV vaccination. In Italy, despite free access, vaccine coverage among adolescents remains low. Psychological factors such as information avoidance (IA), the tendency to ignore threatening information, can influence vaccine decisions and contribute to vaccine hesitancy (VH). While social media offers new avenues for health communication, their effectiveness in reducing VH is uncertain. This study investigates the impact of I…
Rank97.0
Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis.
The Lancet. Microbe · 2026 · PMID 41905375
BACKGROUND: A vaginal microbiota dominated by Lactobacillus species is associated with reduced risk of infection and adverse reproductive outcomes. Effective interventions to restore healthy microbiota remain scarce. In this study, we aimed to assess the efficacy of vaginal microbiota transplants (VMTs) without antibiotic pretreatment in achieving conversion to a Lactobacillus-dominated vaginal microbiome. METHODS: This single-centre, double-blind, randomised controlled trial was done at Copenhagen University Hospi…
Rank96.7
INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2025 · PMID 40300079
PURPOSE: Treatment options for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) after failure of immune checkpoint inhibitor treatment and platinum-based chemotherapy are limited. Preliminary data suggested that monalizumab plus cetuximab had clinical activity in R/M HNSCC. PATIENTS AND METHODS: INTERLINK-1 (NCT04590963) was a double-blind, phase III study. Participants with R/M HNSCC who had received immune checkpoint inhibitor therapy and progressed despite platinum-based chemotherapy were…
Rank96.5
Nonavalent HPV vaccine to prevent recurrent anal or vulvar high-grade squamous intraepithelial lesions (VIVA trial): A randomized, double-blind, placebo-controlled trial.
International journal of cancer · 2026 · PMID 41685810
The nonavalent human papillomavirus (9vHPV) vaccine protects against HPV infection and high-grade squamous intraepithelial lesions (HSIL) when administered prior to exposure, but evidence supporting its potential therapeutic benefit has been inconsistent. This randomized, double-blind, placebo-controlled trial evaluated whether the 9vHPV vaccine reduces recurrence of HSIL or HPV persistence in 27-69-year-old persons previously treated for anal or vulvar HSIL. Participants were HSIL-free at enrollment and received 9…
Rank96.5
Effects of passive information dissemination on human papillomavirus vaccination attitudes and knowledge among pharmacy visitors: A cluster randomized controlled trial.
Journal of the American Pharmacists Association : JAPhA · 2025 · PMID 40782983
BACKGROUND: In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However, the impact of passive information provision in pharmacies on public awareness and behavioral intentions has not been completely evaluated. OBJECTIVES: This study examined whether passive dissemination of HPV vaccine-related information in community pharmacies-through posters and l…
Rank96.4
SEARCH Study: Text Messages and Automated Phone Reminders for HPV Vaccination in Uganda: Randomized Controlled Trial.
JMIR mHealth and uHealth · 2025 · PMID 40324213
BACKGROUND: Cervical cancer is currently the leading female cancer in Uganda. Most women are diagnosed with late-stage disease. Human papillomavirus (HPV) vaccination is the single most important primary preventive measure. While research regarding text message vaccine reminder use is strong in the United States, their use has not yet been demonstrated in a preteen and adolescent population in subSaharan Africa or other low- and middle-income countries. OBJECTIVE: The objective of this pilot randomized controlled t…
Rank96.3
ctDNA and Recurrence Risk for Adjuvant De-Escalation in HPV-Positive Oropharyngeal Carcinoma: A Secondary Analysis of the DART Phase 3 Randomized Clinical Trial.
JAMA otolaryngology-- head & neck surgery · 2025 · PMID 40402484
IMPORTANCE: The De-escalated Adjuvant Radiation Therapy (DART) phase 3 randomized clinical trial (RCT) showed that in patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma, postoperative minimal residual disease (MRD), detected through circulating tumor HPV DNA (ctHPVDNA), was associated with a higher risk of disease progression. When considered along with pathologic factors, postoperative ctHPVDNA assessment may improve patient selection for adjuvant treatment de-escalation; how…
Rank96.2
Early colposcopy in non-16/18 high-risk human papillomavirus positivity with normal cytology.
Revista da Associacao Medica Brasileira (1992) · 2026 · PMID 42339905
OBJECTIVE: Very few clinical studies have been done to evaluate the potential clinical benefit of utilizing early colposcopy in women with normal Pap smear cytology but positive for high-risk human papillomavirus types other than human papillomavirus 16 or human papillomavirus 18 in a screening population for cervical cancer. The aim of this study was to compare two follow-up strategies and assess the need for colposcopy at the initial visit, based on cytology, human papillomavirus testing, and colposcopic findings…
Rank96.1
Intralesional measles, mumps, and rubella vaccine versus vitamin D for treatment of warts: A randomised clinical trial.
Indian journal of dermatology, venereology and leprology · 2026 · PMID 40357930
Background Warts are prevalent distressing skin growths caused by the human papillomavirus (HPV). These growths are commonly addressed using methods that destroy the tissue, including chemical cautery, electrocautery, or cryotherapy. These methods have many side effects in contrast to intralesional immunotherapy. Objectives This study was conducted to assess the effectiveness, safety, and tolerability of utilising the intralesional measles, mumps, and rubella (MMR) vaccine compared to vitamin D in warts treatment. …
Rank96.0
Comparison of topical potassium hydroxide 5% solution with cryotherapy in the treatment of patients with genital warts: A randomized controlled clinical trial.
International journal of STD & AIDS · 2025 · PMID 39600100
BACKGROUND: Given the therapeutic challenge of wart treatment and the need for an ideal treatment that is effective, noninvasive, cost-effective, and has minimal side effects, this study aims to compare the local impact of a 5% potassium hydroxide (KOH) solution with cryotherapy, the current standard treatment for genital warts. METHODS: Two groups, each consisting of 49 patients: the first group was treated with a daily topical application of 5% KOH solution using a swab, while the second group underwent cryothera…
Rank95.9
Acceptability, feasibility and appropriateness of integrating HPV self-sampling for cervical cancer screening into voluntary family planning services in Malawi.
BMC public health · 2025 · PMID 40750852
INTRODUCTION: Despite being preventable, the cervical cancer burden remains high in Malawi and other low-income countries. The World Health Organization recommends cervical cancer screening (CCS) using human papillomavirus (HPV) testing. The coverage of HPV-based CCS is low but may increase with self-sampling of vaginal fluid. We assessed the acceptability, feasibility and appropriateness of two models for integrating HPV self-sampling for CCS into family planning (FP) services in Malawi. METHODS: We conducted a mi…
Rank95.7
A multifaceted, targeted intervention to improve human papillomavirus vaccination rates in general practice: A pragmatic cluster-randomized controlled trial.
Vaccine · 2025 · PMID 40617087
BACKGROUND: Human papillomavirus (HPV) vaccination rates are low in Switzerland. The aim of the study was to test a pragmatic multifaceted targeted intervention among general practitioners (GPs) to increase HPV vaccination (HPVv) rates in general practice. METHODS: In this cluster-randomized controlled trial, two equally sized groups of GPs each received an educational session on vaccination in general and on the national vaccination schedule. Treatment group GPs additionally received detailed information about HPV…
Rank95.7
Short-term outcomes of health belief model-based brief virtual education on HPV infection and vaccination among pharmacy students: a randomized controlled trial.
BMC medical education · 2026 · PMID 41820928
BACKGROUND: Genital Human Papillomavirus (HPV) infection was a global public health concern, with low vaccination rates in Türkiye highlighting a critical need for effective interventions. Pharmacists, as future health advocates, were a crucial target population. This study evaluated the short-term outcomes of brief virtual education program based on the Health Belief Model (HBM) on pharmacy students’ knowledge and health beliefs on HPV infection and vaccination. METHODS: A randomized controlled trial with a pre-te…
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