Viral infections evidence library

Influenza

A living PubMed evidence library for human influenza prevention, antiviral treatment, vaccines, severe disease, resistance, and emerging strains.

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Living evidence synopsis

What the current PubMed collection shows.

Alexandria currently organizes 1,665 non-retracted PubMed-indexed records for Influenza. The structured collection includes 18 guideline or consensus records, 126 evidence syntheses/systematic reviews/meta-analyses, and 130 randomized or phase III studies. 664 records were identified by the configured last-24-month search. Conflict-of-interest statements are available in the PubMed record for 1,401 of 1,665 included records.

Engine 0.3.2 Snapshot v8 Updated 2026-08-14 Download source data · CSV

PubMed records1,665Non-retracted records included

Last 24 months664Records found by the recent-research search

High-priority evidence256Syntheses, reviews, randomized and phase III studies

Effect estimates515Machine-readable values extracted from abstracts

COI statements84.1%Coverage within PubMed records

Funding records459PMIDs with grant/funding metadata

Evidence data

Research landscape

Charts are generated from Alexandria’s structured PubMed records, not copied from journal figures.

Publication activity

Records by publication year

Latest 12 represented years

2005

2014

2016

2020

2021

2022

2023

2024

165

2025

1397

2026

2027

Evidence composition

Study designs

Other or unclassified893

Preclinical/laboratory274

Randomized trials124

Systematic reviews69

Cohort studies63

Case reports61

Meta-analyses57

Prospective cohorts31

Observational studies28

Preprint26

Transparency

Conflict-of-interest reporting

Reported no conflicts703

COI statement present546

Not reported in PubMed record264

Declared financial/industry relationship152

Absence of a conflict-of-interest statement in PubMed does not establish that no conflict existed.

Abstract result signals

Extracted result direction

Not extractable from abstract1509

Neutral/null signal64

Harm signal61

Supportive signal26

Mixed signal5

Reported outcomes

Numerical results extracted from PubMed abstracts

Each value remains attached to its original PMID. Alexandria does not pool these results or imply that unlike populations and endpoints are directly comparable.

Non-pooled ratio measures

Hazard, risk, and odds ratios reported in abstracts

Reference = 1.0

0.250.51.02.04.0

not_reported Odds Ratio · PMID 40166906 · 2026

25.00

not_reported Odds Ratio · PMID 40166906 · 2026

8.30

not_reported Risk Ratio · PMID 40794757 · 2026

1.04 95% CI 1.02–1.05

not_reported Risk Ratio · PMID 40794757 · 2026

1.35 95% CI 1.11–1.65

not_reported Risk Ratio · PMID 40794757 · 2026

1.00 95% CI 1.00–1.00

not_reported Risk Ratio · PMID 40794757 · 2026

1.06 95% CI 0.96–1.17

not_reported Risk Ratio · PMID 40794757 · 2026

1.21 95% CI 0.99–1.48

not_reported Risk Ratio · PMID 40794757 · 2026

1.03 95% CI 0.96–1.10

not_reported Odds Ratio · PMID 41307620 · 2026

0.94 95% CI 0.90–0.99

not_reported Risk Ratio · PMID 41349636 · 2026

0.49 95% CI 0.31–0.79

adverse events Risk Ratio · PMID 41349636 · 2026

0.83 95% CI 0.74–0.94

mortality Risk Ratio · PMID 41349636 · 2026

0.99 95% CI 0.83–1.19

mortality Risk Ratio · PMID 41349636 · 2026

1.11 95% CI 0.86–1.44

not_reported Hazard Ratio · PMID 41360330 · 2026

2.89

View extracted numerical results 60

Publication	Outcome	Measure	Reported value	Source
Clinical features of respiratory syncytial virus and influenza infections in hospitalized adults across three Italian regions.Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace · 2026	not_reported	Odds Ratio	25.0	PMID 40166906
Clinical features of respiratory syncytial virus and influenza infections in hospitalized adults across three Italian regions.Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace · 2026	not_reported	Odds Ratio	8.3	PMID 40166906
Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.International journal of environmental health research · 2026	not_reported	Risk Ratio	1.037 95% CI 1.019–1.055	PMID 40794757
Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.International journal of environmental health research · 2026	not_reported	Risk Ratio	1.351 95% CI 1.107–1.649	PMID 40794757
Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.International journal of environmental health research · 2026	not_reported	Risk Ratio	1.003 95% CI 1.001–1.004	PMID 40794757
Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.International journal of environmental health research · 2026	not_reported	Risk Ratio	1.064 95% CI 0.964–1.174	PMID 40794757
Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.International journal of environmental health research · 2026	not_reported	Risk Ratio	1.207 95% CI 0.988–1.475	PMID 40794757
Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.International journal of environmental health research · 2026	not_reported	Risk Ratio	1.027 95% CI 0.962–1.097	PMID 40794757
Influenza Vaccine Uptake in the Elderly: Biopsychosocial Vulnerabilities and Effectiveness of a Community-Health Worker Administered Preventive Program.Journal of community health · 2026	not_reported	Odds Ratio	0.94 95% CI 0.9–0.99	PMID 41307620
Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.Transplantation and cellular therapy · 2026	not_reported	Risk Ratio	0.49 95% CI 0.31–0.79	PMID 41349636
Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.Transplantation and cellular therapy · 2026	adverse events	Risk Ratio	0.83 95% CI 0.74–0.94	PMID 41349636
Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.Transplantation and cellular therapy · 2026	mortality	Risk Ratio	0.99 95% CI 0.83–1.19	PMID 41349636
Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.Transplantation and cellular therapy · 2026	mortality	Risk Ratio	1.11 95% CI 0.86–1.44	PMID 41349636
Cladribine as an Alternative to Fludarabine in Melphalan and Total Body Irradiation-Based Reduced Intensity Conditioning.Transplantation and cellular therapy · 2026	not_reported	Percentage Comparison	62.8percent vs 33.3percent P = .04	PMID 41360330
Cladribine as an Alternative to Fludarabine in Melphalan and Total Body Irradiation-Based Reduced Intensity Conditioning.Transplantation and cellular therapy · 2026	not_reported	Hazard Ratio	2.89 P = .008	PMID 41360330
Disparities in uptake of Shingrix® vaccine in immunosuppressed individuals in England: a population-based cohort study.Vaccine · 2026	not_reported	Odds Ratio	0.53	PMID 41435736
Disparities in uptake of Shingrix® vaccine in immunosuppressed individuals in England: a population-based cohort study.Vaccine · 2026	not_reported	Odds Ratio	0.61	PMID 41435736
Impact of Real-Time, On-Demand Influenza and Respiratory Syncytial Virus Testing at Point-of-Care on Antibiotic Prescribing and Clinical Outcome in Pediatric Outpatients With Acute Respiratory Illness: A Prospective, Quasi-Randomized, Controlled Study.Influenza and other respiratory viruses · 2026	not_reported	Odds Ratio	0.366	PMID 41474255
Impact of Real-Time, On-Demand Influenza and Respiratory Syncytial Virus Testing at Point-of-Care on Antibiotic Prescribing and Clinical Outcome in Pediatric Outpatients With Acute Respiratory Illness: A Prospective, Quasi-Randomized, Controlled Study.Influenza and other respiratory viruses · 2026	not_reported	Odds Ratio	3.99	PMID 41474255
[Vaccination of Older Adults in Portugal: Recommendations from the Geriatrics Study Group of the Portuguese Society of Internal Medicine].Acta medica portuguesa · 2026	not_reported	Odds Ratio	21.0	PMID 41490687
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	3.64	PMID 41529699
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	3.65	PMID 41529699
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	2.31	PMID 41529699
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	3.76	PMID 41529699
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	2.04	PMID 41529699
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	2.32	PMID 41529699
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	0.51	PMID 41529699
Serological protection against influenza and cardiovascular events in cardiac ICU patients during seasonal epidemics.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026	not_reported	Percentage Comparison	84.6percent vs 37.5percent P < 0.001	PMID 41570890
Serological protection against influenza and cardiovascular events in cardiac ICU patients during seasonal epidemics.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026	not_reported	Percentage Comparison	28.2percent vs 40.8percent P = 0.009	PMID 41570890
Serological protection against influenza and cardiovascular events in cardiac ICU patients during seasonal epidemics.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026	not_reported	Percentage Comparison	0.8percent vs 4.6percent P = 0.009	PMID 41570890
Serological protection against influenza and cardiovascular events in cardiac ICU patients during seasonal epidemics.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026	not_reported	Percentage Comparison	53.1percent vs 67.1percent P = 0.009	PMID 41570890
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026	not_reported	Odds Ratio	100.0	PMID 41627968
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.Human vaccines & immunotherapeutics · 2026	adverse events	Odds Ratio	2.0	PMID 41627968
Effect of influenza vaccination in patients with decompensated heart failure: a systematic review and meta-analysis.European journal of heart failure · 2026	mortality	Hazard Ratio	0.86 95% CI 0.76–0.96	PMID 41771112
Effect of influenza vaccination in patients with decompensated heart failure: a systematic review and meta-analysis.European journal of heart failure · 2026	mortality	Odds Ratio	0.85 95% CI 0.7–1.01	PMID 41771112
Association Between Maternal Infection During Pregnancy and the Risk of Childhood Acute Lymphoblastic Leukemia in Offspring: A Systematic Review and Meta-Analysis.Pediatric blood & cancer · 2026	not_reported	Odds Ratio	1.45 95% CI 1.0–2.09	PMID 41834321
Association Between Maternal Infection During Pregnancy and the Risk of Childhood Acute Lymphoblastic Leukemia in Offspring: A Systematic Review and Meta-Analysis.Pediatric blood & cancer · 2026	not_reported	Odds Ratio	1.18 95% CI 1.0–1.39	PMID 41834321
Association Between Maternal Infection During Pregnancy and the Risk of Childhood Acute Lymphoblastic Leukemia in Offspring: A Systematic Review and Meta-Analysis.Pediatric blood & cancer · 2026	not_reported	Odds Ratio	1.44 95% CI 1.03–2.01	PMID 41834321
Immunogenicity and safety of higher-dose cell-based adjuvanted quadrivalent influenza vaccines: Combined results of randomised, controlled dose-finding and dose-confirmation studies.Vaccine · 2026	not_reported	Odds Ratio	45.0	PMID 41855648
Mortality and Morbidity Benefit After Influenza Vaccination in High Cardiovascular Risk Population: A Systematic Review and Meta-analysis.The American journal of cardiology · 2026	mortality	Hazard Ratio	0.72 95% CI 0.63–0.82	PMID 41951138

Research transparency

Funding and conflicts of interest

Conflict and funding fields reproduce what is available in PubMed records. Missing disclosure data does not establish that no conflict or funding existed.

COI statement coverage84.1%264 records have no COI statement exposed in PubMed.

Funding metadata coverage27.6%Coverage indicates whether grant/funding metadata was present, not independence or study quality.

Most frequently reported funding agencies

NIAID NIH HHS122

National Natural Science Foundation of China57

NIH HHS43

NHLBI NIH HHS23

NCATS NIH HHS17

NCIRD CDC HHS17

NCI NIH HHS17

NIGMS NIH HHS13

View records with declared financial or industry relationships 12

Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults.

Conflict of Interest Disclosures: Dr Wiegand reported stock in Sanofi S.A. and Merck & Co outside the submitted work. Dr Klein reported grants from the Centers for Disease Control and Prevention during the conduct of the study, as well as grants from Pfizer, Moderna, Merck, Sanofi, AstraZeneca, Janssen, GlaxoSmithKline, and Seqirus outside the submitted work. Dr Grannis reported grants from the Centers for Disease Control and Prevention during the conduct of the study. Dr Rowley reported a contract with the University of Utah with prime funding and drug provided by Novavax, as well as payments from Novavax made to employer outside the submitted work. Dr DeSilva reported institutional grants from Westat during the conduct of the study. Ms Irving reported institutional grants from Westat during the conduct of the study. Dr Zerbo reported grants from Moderna, Pfizer, and the National Institute of Allergy and Infectious Diseases outside the submitted work. Dr Hansen reported institutional grants from the Centers for Disease Control and Prevention during the conduct of the study. Dr Jacobson reported grants from the Centers for Disease Control and Prevention during the conduct of the study, as well as grants from the National Institute of Allergy and Infectious Diseases, the American Society of Tropical Medicine and Hygiene, and Pfizer outside the submitted work. Prof Dixon reported institutional grants from the Centers for Disease Control and Prevention during the conduct of the study. Dr Fadel reported grants from the Centers for Disease Control and Prevention during the conduct of the study. Dr Mayer reported institutional grants from Westat during the conduct of the study. Dr Ball reported grants paid to employer from the Centers for Disease Control and Prevention, the University of Utah, and Novavax outside the submitted work. Dr McEvoy reported institutional grants from the Centers for Disease Control and Prevention during the conduct of the study, as well as grants from Invivyd outside the submitted work. Dr Sheffield reported grants from the Centers for Disease Control and Prevention during the conduct of the study. Dr Naleway reported grants from the Centers for Disease Control and Prevention during the conduct of the study, as well as grants from the Centers for Disease Control and Prevention and the National Institutes of Health outside the submitted work. Dr Natarajan reported grants from the Centers for Disease Control and Prevention during the conduct of the study, as well as grants from the National Institutes of Health outside the submitted work. No other disclosures were reported.

PMID 42295789 · 2026

Vaccines for preventing infections in adults with haematological malignancies.

AMZ: staff at Cochrane Evidence Synthesis Unit Germany/UK and Cochrane Haematology, but not involved in the editorial process. CH: deputy head of Cochrane Evidence Synthesis Unit Germany/UK and Managing Editor at Cochrane Haematology, but not involved in the editorial process. MB: staff at Cochrane Haematology, but not involved in the editorial process. MF: staff at Cochrane Haematology, but not involved in the editorial process. PJB: BeiGene (grant/contract), Bristol‐Meyers Squibb Foundation (grant/contract), Celgene (travel), Merck Sharp and Dohme (consultant), Stemline Therapeutics (consultant), Takeda Oncology (consultant). SM: Gilead Foundation (travel), Octapharma USA Inc (consultant). IM: Information Specialist at Cochrane Evidence Synthesis Unit Germany/UK and Cochrane Haematology, but not involved in the editorial process. NS: lead of Cochrane Evidence Synthesis Unit Germany/UK and Co‐ordinating Editor of Cochrane Haematology, but not involved in the editorial process. NK: staff at Cochrane Evidence Synthesis Unit Germany/UK and Cochrane Haematology, but not involved in the editorial process

PMID 40396505 · 2025

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis.

Conflict of Interest Disclosures: Dr Lassen reported receiving speaker fees from Pfizer Inc outside the submitted work. Dr Johansen reported receiving personal fees from Sanofi SA outside the submitted work. Dr Loiacono reported being employed by Sanofi SA during the conduct of the study and outside the submitted work. Dr Harris reported being employed by Sanofi SA and holding shares during the conduct of the study. Dr Samson reported being employed by Sanofi SA during the conduct of the study and outside the submitted work. Dr Palmu reported receiving grant support from Sanofi SA during the conduct of the study; receiving grant support from Sanofi SA, GSK, Pfizer Inc, MSD, Moderna Inc, CSL Seqirus, Abbott Laboratories, and Osivax outside the submitted work; and serving on advisory boards for and receiving travel reimbursement from Sanofi SA, GSK, Pfizer Inc, MSD, and BioNet-Asia outside the submitted work. Dr McConeghy reported receiving grant support from Sanofi-Pasteur during the conduct of the study and grant support from CSL Seqirus, Pfizer Inc, Moderna Inc, Genentech Inc, and GSK outside the submitted work. Dr Gravenstein reported receiving grant support from Sanofi SA, Moderna Inc, Pfizer Inc, and GSK and consulting and speaking fees from Sanofi SA, Moderna Inc, GSK, Johnson & Johnson, AstraZeneca–Icosavax Inc, and CSL Seqirus outside the submitted work. Dr Vardeny reported receiving personal fees from Moderna Inc outside the submitted work. Dr Claggett reported receiving consulting fees from Alnylam Pharmaceuticals Inc, Cardior, Cardurion Pharma, CVRx Inc, Intellia Therapeutics Inc, Rocket Pharmaceuticals Inc, Eli Lilly and Co, and Alexion Pharmaceuticals Inc outside the submitted work. Dr Solomon reported receiving grant support from Alexion Pharmaceuticals Inc, Alnylam Pharmaceuticals Inc, Applied Therapeutics Inc, AstraZeneca, Bellerophon Therapeutics, Bayer AG, BMS, Boston Scientific Corp, Cardior, Cytokinetics Inc, Edgewise Therapeutics, BridgeBio Pharma Inc, Gossamer Bio, GSK, Ionis Phamaceuticals Inc, Eli Lilly and Co, the National Heart, Liver, and Blood Institute of the National Institutes of Health (NIH), Novartis AG, NovoNordisk A/S, Respicardia, Sanofi Pasteur, Tenaya Therapeutics Inc, TheracosBio, and US2.AI and personal fees from Abbott Laboratories, Action Pharma A/S, Akros Pharma Inc, Alexion Pharmaceuticals Inc, Alnylam Pharmaceuticals Inc, Amgen Inc, Arena Pharmaceuticals Inc, AskBio, AstraZeneca, Bayer AG, BMS, Bridgebio Pharma Inc, Cardior, Cardurion Pharma, Corvia Medical, Cytokinetics Incorporated, GSK, Intellia Therapeutics Inc, Eli Lilly and Company, Novartis AG, F. Hoffmann–La Roche AG, TheracosBio, Quantum Genomics, Tenaya Therapeutics Inc, Sanofi Pasteur, DiNAQOR, Tremeau Pharmaceuticals, CellProthera, Moderna Inc, American Regent Inc, Sarepta Therapeutics Inc, Lexicon Pharmaceuticals Inc, AnaCardio AB, Akros Pharma Inc, Valo Health, Synhale Therapeutics, and Recordati outside the submitted work. Dr Martinón-Torres reported receiving grant support (to institution) from Sanofi SA during the conduct of the study and grant support (to institution) from AstraZeneca, Sanofi SA, Pfizer Inc, and GSK and personal fees from AstraZeneca, Sanofi SA, Pfizer Inc, GSK, MSD-Merck, Biofabri, CSL Seqirus, Moderna Inc, and HIPRA outside the submitted work. Dr Biering-Sørensen reported receiving grant support from Sanofi Pasteur, GSK, NovoNordisk A/S, AstraZeneca, Boston Scientific Corp, GE Healthcare, Bayer AG, Novartis AG, Moderna Inc, and Pfizer Inc; consulting and lecture fees from Sanofi Pasteur and GSK; consulting fees from IQVIA, Parexel, Amgen Inc, and CSL Seqirus; and lecture fees from Bayer AG, Novartis AG, and Pfizer Inc outside the submitted work. No other disclosures were reported.

PMID 42189540 · 2026

Mucosal immune cell priming by intranasally delivered Haemophilus haemolyticus is associated with heterologous protection against influenza and nontypeable Haemophilus influenzae.

Author SW was employed by company BioscienceConnect. CG, PR and L-AK are inventors on patents using H. haemolyticus to prevent respiratory infections including otitis media. L-AK and PR are Founding Directors and shareholders of Oto Medicines Pty Ltd, a private company developing therapies to prevent and treat otitis media. PR has served on immunisation scientific advisory boards for Clover Biopharmaceuticals, GlaxoSmithKline, Merck Sharp Dome, Moderna, Pfizer, and Sanofi with institutional payments. His institution has received research funding from MSD and Pfizer for studies of RSV epidemiology and vaccine effectiveness. He has chaired the Western Australian Steering Group for Ear Health to advocate for improved detection and treatment of otitis media unpaid. The remaining authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

PMID 42548815 · 2026

How Pandemics Have Reshaped the Respiratory Virus Data Landscape in Europe: Scoping Review.

Conflicts of Interest: CM is an employee of Sanofi and owns stock. MCN reports research grants from Sanofi and personal fees from Pfizer and Sanofi.

PMID 42467815 · 2026

Community-Acquired Pneumonia in Nursing-Home Residents in the Post-Health Care-Associated Pneumonia Era.

Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: J. M. P. reports having received consulting fees from the MSD, Madrigal, Boehringer-Ingelheim, and Novo Nordisk; speaking fees from Madrigal, Gilead, Intercept, and Novo Nordisk; travel expenses from Gilead, Rubió, Pfizer, Astellas, MSD, CUBICIN, and Novo Nordisk; and educational and research support from Madrigal, Boehringer-Ingelheim, Gilead, Pfizer, Astellas, Accelerate, Novartis, AbbVie, ViiV, and MSD. None declared (C. C., M. I. R.).

PMID 42425406 · 2026

Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs.

The J.A.R. laboratory received support from Tonix Pharmaceuticals, Xing Technologies, Esperovax, and Zoetis, outside of the reported work. J.A.R. is inventor on patents and patent applications on the use of antivirals and vaccines for the treatment and prevention of virus infections, owned by Kansas State University.

PMID 40396285 · 2025

A consensus HA DNA vaccine targeting clade 2.3.4.4 H5Nx influenza viruses provides broad cross-clade protection in mice and ferrets.

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Doo-Jin Kim has patent issued to Chungbuk National University Industry Cooperation Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

PMID 40902412 · 2025

Insights on the practical application of the current treatment consensus in rhabdomyolysis management: a case report.

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Written consent for publication of clinical details has been obtained from the patient and the parental guardian prior to submission. Competing interests: T.R. has received funding for lectures and has been consultant or advisory board member for Alexion, AstraZeneca, B. Braun, Baxter, bioMérieux, Boehringer Ingelheim, Contatti (CytoSorbents), Eurofarma, George Clinical, Jafron, Lifepharma, Medcorp, Nipro, and Nova Biomedical; S. M. is shareholder of Artcline GmbH and received funding for lectures and has been consultant or advisory board member Cytosorbents Europe GmbH; C.R. has been on advisory boards or speaker’s bureau for AstraZeneca, Aferetica, Asahi, B. Braun, Baxter, bioMérieux, CytoSorbents, GE, Medica, Medtronic, and Jafron; G.K. has received funding for lectures for Artcline GmbH and Cytosorbents Europe GmbH and has received research grants from the German Society of Anaesthesiology and Intensive Care.

PMID 41267038 · 2025

Management of Invasive Pulmonary Aspergillosis in Intensive Care Units: Guidelines From the Fungal Infection Network of Switzerland (FUNGINOS).

Outside of the present work: F. Lamoth: research funding from MSD, Pfizer and Novartis, speaker honoraria from Gilead, MSD, Pfizer, Mundipharma and Becton‐Dickinson. W. Albrich: speaker honoraria from Pfizer, GSK, MSD and A. Vogel; travel support from Pfizer, Gilead and GSK; participation in advisory boards for Pfizer, MSD, GSK, Sanofi, Moderna, Janssen and Aurovir. I. Reinhold: speaker honoraria from Menarini Group. J. Sumer: travel support from Gilead. V. Bättig: travel support from Gilead. A. Conen: travel support from Gilead. E. Hofmann: travel support from Gilead and Astra Zeneca. C. Le Terrier: speaker and advisory boards honoraria from Advanz Pharma. N.J. Rupp: travel support from Roche Diagnostics AG, honoraria for advisory board from AbbVie AG. P.W. Schreiber: travel supports from Pfizer and Gilead. F. Kadgien: travel supports from Tillots and Gilead. D. Neofytos: research grants from MSD, Pfizer and Takeda, speaker honoraria from Pfizer, Gilead, MSD and Takeda, participation on advisory board for Novo Nordisk and travel support from Gilead. N. Khanna: honoraria for conferences, data safety monitoring boards or advisory boards from Gilead, MSD, Pfizer, Idorsia, Takeda and Pulmicide.

PMID 41311305 · 2025

Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization.

DBW has received grant funding from industry for sponsored research collaborations, he has received speaking honoraria and received fees for consulting or serving on scientific review committees. Remunerations received by DBW include direct payments and equity/options. DBW also discloses the following associations with commercial partners: Geneos consultant/advisory board, AstraZeneca advisory board and speaker, Inovio board of directors and consultant, Sanofi advisory board, BBI advisory board, Pfizer advisory board, Flagship consultant, and Advaccine consultant. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.

PMID 41383614 · 2025

Predictors of initiation and completion of Shingrix vaccination in immunocompetent adults newly eligible for vaccination from 2018-2024.

All authors are employees of Truveta, Inc. and hold equity in the company.

PMID 42301805 · 2026

Archivos de bronconeumologia · 2026

Vaccines are a fundamental public health tool, particularly effective in preventing respiratory infections. Their importance is amplified in patients with chronic respiratory diseases, who are more susceptible to acute infections such as influenza, pneumococcus, COVID-19, respiratory syncytial virus (RSV), pertussis, and herpes zoster. These individuals face an increased risk of severe infections, exacerbations, hospitalizations, and mortality. Vaccination against influenza, pneumococcus, and SARS-CoV-2 significantly reduces these adverse outcomes. Evidence also supports the use of vaccines against RSV, pertussis, and herpes zoster in this population. In specific cases, tailored immunization…

PMID 40592680

Pediatric blood & cancer · PMID 41834321

Treatment Options Studied in the PubMed Collection

These are interventions detected in PubMed metadata and abstracts. Inclusion does not establish approval, effectiveness, suitability, or standard-of-care status.

moderate-confidence evidence

Influenza Vaccines

184 linked PMIDs1496919 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality, adverse events, pneumonia, vaccine effectiveness, quality of life, seroconversion, hospitalization
Populations represented: general population; influenza A; children; older adults; influenza A; seasonal influenza; seasonal influenza
Mechanism: With the advancement in synthetic biology and reverse genetics technologies, a variety of next-generation attenuated influenza virus have been developed, including genome-recoded viruses, miRNA-targeted viruses, viruses containing premature termination codons, and proteolysis-targeting recombinantviruses METHODS: A novel adjuvant VP, formulated with squalene, sea buckthorn oil, and the TLR3 agonist Poly(I: C), was designed

PMID 42121086 PMID 40068961 PMID 42248304 PMID 37673716 PMID 42370650 PMID 39486820 PMID 40835927 PMID 36941155

preliminary evidence

influenza vaccine

107 linked PMIDs897528 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, vaccine effectiveness, mortality, serious adverse events, seroconversion, quality of life, hospitalization
Populations represented: general population; seasonal influenza; children; older adults; influenza A; influenza A; older adults
Mechanism: METHODS: A two-phase randomized controlled trial will be conducted in community hospitals across China targeting healthcare workers as participants By targeting healthcare workers, these interventions can also indirectly enhance vaccination coverage in the general population

PMID 42121086 PMID 42248304 PMID 37673716 PMID 36941155 PMID 40523466 PMID 42365746 PMID 42506592 PMID 42135702

moderate-confidence evidence

Antiviral Agents

80 linked PMIDs37142 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality, adverse events, pneumonia, hospitalization
Populations represented: influenza A; general population; influenza A; neuraminidase; neuraminidase; avian influenza; children
Mechanism: Its active metabolite, GP1707D07, specifically inhibits PA endonuclease activity ELISA confirmed the significant regulation of C4BPB (P = 0.0003) and IFI6 (P = 0.016), consistent with proteomics.CGQSD mediates anti-influenza activity through a dual immunomodulatory mechanism centered on "Complement-Interferon Homeostasis," targeting C4BPB (a complement regulator) and IFI6 (an interferon-stimulated gene)

PMID 42450260 PMID 41870058 PMID 42520626 PMID 41927824 PMID 41932663 PMID 42419220 PMID 42275269 PMID 42229293

moderate-confidence evidence

Antibodies, Viral

76 linked PMIDs6147 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, seroconversion, mortality, vaccine effectiveness
Populations represented: influenza A; general population; influenza A; hemagglutinin; avian influenza; hemagglutinin; hemagglutinin; avian influenza
Mechanism: While both binding and neutralizing antibody titers against SARS-CoV-2 were not significantly different between groups postvaccination, there was a higher fold-change in BA.5 and ancestral strain neutralizing antibodies in the opposite-arm group.CONCLUSIONInfluenza vaccination is equivalently immunogenic if given in the same arm or opposite arms as the SARS-CoV-2 vaccine, but it may be preferable to administer the SARS-CoV-2 vaccine at a different site from influenza vaccines.TRIAL REGISTRATIONAustralian New Zealand Clinical Trials Registry ACTRN12624000445572.FUNDINGAustralian National Health and Medical Research Council, Australian Medical Research Future Fund, and National Institutes of H In this study, 27 healthy volunteers with low strain-specific serum neutralizing antibody levels were challenged with influenza A/H3N2 virus

PMID 39041887 PMID 39786918 PMID 42492070 PMID 42378965 PMID 42184288 PMID 42303005 PMID 42492242 PMID 42019812

higher-confidence evidence

COVID-19 Vaccines

54 linked PMIDs33294 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events, mortality, serious adverse events, pneumonia, vaccine effectiveness, hospitalization, seroconversion
Populations represented: influenza A; general population; older adults; influenza A; seasonal influenza; influenza A; children; influenza A; neuraminidase
Mechanism: While both binding and neutralizing antibody titers against SARS-CoV-2 were not significantly different between groups postvaccination, there was a higher fold-change in BA.5 and ancestral strain neutralizing antibodies in the opposite-arm group.CONCLUSIONInfluenza vaccination is equivalently immunogenic if given in the same arm or opposite arms as the SARS-CoV-2 vaccine, but it may be preferable to administer the SARS-CoV-2 vaccine at a different site from influenza vaccines.TRIAL REGISTRATIONAustralian New Zealand Clinical Trials Registry ACTRN12624000445572.FUNDINGAustralian National Health and Medical Research Council, Australian Medical Research Future Fund, and National Institutes of H As a primary regimen, the Flu‑CoV2 vaccine effectively induced strong IgG and neutralizing antibody responses against both influenza and SARS‑CoV‑2

PMID 42388750 PMID 42000586 PMID 39786918 PMID 40639178 PMID 42492070 PMID 42468225 PMID 39436660 PMID 35914122

limited evidence

Hemagglutinin Glycoproteins, Influenza Virus

43 linked PMIDs170 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, viral shedding, mortality
Populations represented: avian influenza; hemagglutinin; influenza A; hemagglutinin; hemagglutinin; influenza A; avian influenza; hemagglutinin; influenza A; general population
Mechanism: Vaccination elicited strong neutralizing antibody and T cell responses, protecting mice against lethal challenge with homologous viruses Nanobody, the variable domain of heavy chain-only antibody, offers unique advantages for viral neutralization due to its small size, stability, and accessibility to cryptic epitopes.Methods:In this study, we isolated a human nanobody, nAb35, targeting the hemagglutinin of the dairy cattle H5N1 virus A/Texas/37/2024 (clade 2.3.4.4b) via phage display of a human nanobody library

PMID 42097265 PMID 42306856 PMID 42288138 PMID 40396285 PMID 40902412 PMID 42370406 PMID 41950927 PMID 42429648

moderate-confidence evidence

oseltamivir

28 linked PMIDs34696 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, hospitalization, adverse events, mortality, symptom duration, serious adverse events, pneumonia
Populations represented: influenza A; general population; children; influenza A; children; first-line; neuraminidase; influenza A; avian influenza
Mechanism: ELISA confirmed the significant regulation of C4BPB (P = 0.0003) and IFI6 (P = 0.016), consistent with proteomics.CGQSD mediates anti-influenza activity through a dual immunomodulatory mechanism centered on "Complement-Interferon Homeostasis," targeting C4BPB (a complement regulator) and IFI6 (an interferon-stimulated gene) Influenza A virus remains a global health threat due to its high mutation rate and its resistance to existing neuraminidase and polymerase inhibitors

PMID 38185405 PMID 42450260 PMID 42520626 PMID 42566960 PMID 42275269 PMID 42568914 PMID 41939777 PMID 41851897

moderate-confidence evidence

RNA, Viral

20 linked PMIDs779 reported cumulative sample signal

Research status: mostly neutral
Outcomes represented: reported clinical outcomes, adverse events, serious adverse events, mortality
Populations represented: influenza A; general population; influenza A; avian influenza
Mechanism: Here, we perform an integrative meta-analysis of eight published SARS-CoV-2 RNA-protein interactomes and compare them with corresponding Influenza A virus, Zika virus, and Dengue virus datasets to define conserved host networks and prioritize candidate host-directed antiviral targets Together, these findings generate a consensus map of conserved host dependencies and highlight prioritized targets for future mechanistic and translational studies

PMID 42149692 PMID 42075765 PMID 41777069 PMID 42184674 PMID 42294731 PMID 40760206 PMID 41692223 PMID 42363877

preliminary evidence

Antibodies, Neutralizing

20 linked PMIDs56 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality
Populations represented: general population; influenza A; avian influenza; hemagglutinin; influenza A; hemagglutinin; influenza A; avian influenza; hemagglutinin; neuraminidase; influenza A; neuraminidase
Mechanism: While both binding and neutralizing antibody titers against SARS-CoV-2 were not significantly different between groups postvaccination, there was a higher fold-change in BA.5 and ancestral strain neutralizing antibodies in the opposite-arm group.CONCLUSIONInfluenza vaccination is equivalently immunogenic if given in the same arm or opposite arms as the SARS-CoV-2 vaccine, but it may be preferable to administer the SARS-CoV-2 vaccine at a different site from influenza vaccines.TRIAL REGISTRATIONAustralian New Zealand Clinical Trials Registry ACTRN12624000445572.FUNDINGAustralian National Health and Medical Research Council, Australian Medical Research Future Fund, and National Institutes of H In this study, 27 healthy volunteers with low strain-specific serum neutralizing antibody levels were challenged with influenza A/H3N2 virus

PMID 42523047 PMID 42522246 PMID 42435621 PMID 42199422 PMID 42433349 PMID 39786918 PMID 42482445 PMID 42387215

preliminary evidence

Neuraminidase

19 linked PMIDs29409 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, mortality
Populations represented: influenza A; neuraminidase; influenza A; hemagglutinin; neuraminidase; neuraminidase; seasonal influenza; neuraminidase; first-line; neuraminidase; influenza A; pandemic influenza; neuraminidase; children
Mechanism: Virus phenotype and vaccination targeting prior dominant HA clades likely contributed to the clade's success The first vaccines targeting specifically the H2N2 subtype were available in autumn 1957, but their limited immunogenicity hampered a successful fight against the "Asian influenza pandemic"

PMID 41985745 PMID 42515613 PMID 40983409 PMID 40425963 PMID 40017110 PMID 42497629 PMID 35766502 PMID 41895046

preliminary evidence

Pneumococcal Vaccines

17 linked PMIDs11721 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: pneumonia, mortality, reported clinical outcomes, adverse events, serious adverse events
Populations represented: older adults; influenza A; influenza A; older adults; seasonal influenza
Mechanism: Findings suggest that, except among older adults with poor, physical health tailored public health intervention policies to boost older adults' overall willingness for the three key vaccines should prioritize targeting vaccination-related beliefs (self-efficacy, benefits, costs, and risk of infection) rather than disease severity We evaluate vaccines targeting influenza, Streptococcus pneumoniae, SARS-CoV-2, and other relevant pathogens, and explore determinants influencing vaccine efficacy, including optimal timing, formulation, and patient-specific immune parameters

PMID 41871621 PMID 41724515 PMID 41974623 PMID 40931721 PMID 42322680 PMID 42033452 PMID 40716013 PMID 42000586

preliminary evidence

Vaccines

17 linked PMIDs2096 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events
Populations represented: general population; influenza A; children; advanced
Mechanism: Despite the Affordable Care Act (ACA) eliminating cost-sharing for recommended vaccines in 2010, adult vaccination rates persistently fall below Healthy People 2030 targets, signaling that access alone is insufficient We summarize the mechanisms and clinical relevance of licensed and advanced adjuvants, including alum, MF59, AS01/AS04, saponins, toll-like receptor agonists, and lipid nanoparticles, with emphasis on influenza, HPV, herpes zoster, and COVID-19 vaccines

PMID 42246489 PMID 40531668 PMID 42022831 PMID 41960944 PMID 41921478 PMID 41686683 PMID 42430872 PMID 39902893

preliminary evidence

Viral Proteins

17 linked PMIDs170 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes
Populations represented: influenza A; avian influenza; influenza A; avian influenza; influenza A; hemagglutinin; neuraminidase; seasonal influenza; neuraminidase; influenza A; seasonal influenza; pandemic influenza; hemagglutinin; neuraminidase
Mechanism: Mechanistically, viral nucleoprotein and non-structural protein 1 interact with host paraspeckle proteins, the viral endonuclease PA-X degrades long non-coding RNA housed within paraspeckles and viral RNA polymerase II is inhibited to drive paraspeckle disruption, which releases host factors that facilitate IAV replication Here we develop an autophagy-targeting influenza

PMID 42357666 PMID 42203763 PMID 42477070 PMID 42049736 PMID 42294629 PMID 42294954 PMID 42246480 PMID 42208335

limited evidence

Cytokines

14 linked PMIDs581 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, pneumonia, mortality
Populations represented: general population; influenza A
Mechanism: Mechanistically, GGD suppressed the STAT3/HIF-1α signaling axis and downregulated downstream pro-inflammatory mediators METHODS: A novel adjuvant VP, formulated with squalene, sea buckthorn oil, and the TLR3 agonist Poly(I: C), was designed

PMID 42286357 PMID 42385325 PMID 42155037 PMID 41668586 PMID 42104474 PMID 42280435 PMID 42492242 PMID 41903607

moderate-confidence evidence

Anti-Bacterial Agents

14 linked PMIDs163 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: pneumonia, reported clinical outcomes, hospitalization, mortality, adverse events
Populations represented: influenza A; general population; children; first-line; influenza A; children
Mechanism: Mechanistically, antibiotic intervention exacerbated IAV-caused excessive inflammatory responses by the blockage of pulmonary-intestinal antiviral immune pathways, which were caused by the upregulation of PKR, RIG-I, ISG15, and TRIM25 levels while downregulating IPS-1 mRNA levels

PMID 42133613 PMID 42249277 PMID 42026464 PMID 42026892 PMID 41845258 PMID 40307109 PMID 40817233 PMID 41850624

moderate-confidence evidence

Vaccines, Inactivated

12 linked PMIDs7942 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: adverse events, seroconversion, reported clinical outcomes, quality of life, serious adverse events, vaccine effectiveness
Populations represented: children; general population; influenza A; influenza A; children; seasonal influenza
Mechanism: While both binding and neutralizing antibody titers against SARS-CoV-2 were not significantly different between groups postvaccination, there was a higher fold-change in BA.5 and ancestral strain neutralizing antibodies in the opposite-arm group.CONCLUSIONInfluenza vaccination is equivalently immunogenic if given in the same arm or opposite arms as the SARS-CoV-2 vaccine, but it may be preferable to administer the SARS-CoV-2 vaccine at a different site from influenza vaccines.TRIAL REGISTRATIONAustralian New Zealand Clinical Trials Registry ACTRN12624000445572.FUNDINGAustralian National Health and Medical Research Council, Australian Medical Research Future Fund, and National Institutes of H Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses

PMID 41940741 PMID 41386374 PMID 41920404 PMID 42000149 PMID 36941155 PMID 42286357 PMID 39786918 PMID 42303005

preliminary evidence

Vaccines, Attenuated

10 linked PMIDs412 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: reported clinical outcomes, adverse events
Populations represented: influenza A; general population; children
Mechanism: We previously developed a proteolysis-targeting (PROTAR) vaccine technology by artificially fusing a proteasome-targeting degron (PTD) to the C terminus of influenza A viral M1 protein Here we develop an autophagy-targeting influenza

PMID 42303005 PMID 41721587 PMID 42012179 PMID 42049736 PMID 42419427 PMID 42515567 PMID 39116029 PMID 39932481

preclinical evidence only

Drugs, Chinese Herbal

9 linked PMIDs140 reported cumulative sample signal

Research status: insufficiently reported
Outcomes represented: pneumonia, reported clinical outcomes, serious adverse events, adverse events
Populations represented: influenza A; general population
Mechanism: Integrating absorbed components and network pharmacology to predict its potential for treating influenza and its mechanism of action ELISA confirmed the significant regulation of C4BPB (P = 0.0003) and IFI6 (P = 0.016), consistent with proteomics.CGQSD mediates anti-influenza activity through a dual immunomodulatory mechanism centered on "Complement-Interferon Homeostasis," targeting C4BPB (a complement regulator) and IFI6 (an interferon-stimulated gene)

PMID 42543264 PMID 41651040 PMID 41850635 PMID 42520626 PMID 41932663 PMID 41671880 PMID 42385325 PMID 42507727

Conflicting Research

higher-confidence evidence

Influenza Vaccines · multiple reported outcomes

73 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 62null: 5harm: 5benefit: 1

PMID 40396505 PMID 41248504 PMID 41951138 PMID 41961609 PMID 40013540 PMID 41939928 PMID 40973981 PMID 41771112 PMID 41654878 PMID 42121086

higher-confidence evidence

influenza vaccine · multiple reported outcomes

57 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 49null: 4harm: 3benefit: 1

PMID 40396505 PMID 41248504 PMID 41939928 PMID 42403499 PMID 40973981 PMID 42121086 PMID 42534960 PMID 41855648 PMID 42248304 PMID 41936374

higher-confidence evidence

Influenza Vaccines · multiple reported outcomes

43 studies

Status: apparently conflicting; different clinical questions. Population: influenza A. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 35null: 5benefit: 1harm: 2

PMID 42388750 PMID 41946219 PMID 42000586 PMID 42397204 PMID 39041887 PMID 41232749 PMID 41259756 PMID 39786918 PMID 38526550 PMID 39504023

higher-confidence evidence

Influenza Vaccines · multiple reported outcomes

31 studies

Status: apparently conflicting; different clinical questions. Population: older adults. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 26null: 2benefit: 1harm: 2

PMID 42476160 PMID 42189540 PMID 42273673 PMID 39230284 PMID 41167013 PMID 42081247 PMID 39446325 PMID 41806760 PMID 41609947 PMID 41539381

higher-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

31 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 24null: 3harm: 4

PMID 40396505 PMID 40592680 PMID 41961609 PMID 42248304 PMID 40239211 PMID 38602539 PMID 41620671 PMID 39486820 PMID 41680545 PMID 41780104

higher-confidence evidence

Antibodies, Viral · multiple reported outcomes

22 studies

Status: apparently conflicting; different clinical questions. Population: general population. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 19null: 2benefit: 1

PMID 41939928 PMID 41855648 PMID 42248304 PMID 38177116 PMID 41936374 PMID 40600710 PMID 41620671 PMID 36941155 PMID 42167137 PMID 41617520

higher-confidence evidence

influenza vaccine · multiple reported outcomes

21 studies

Status: apparently conflicting; different clinical questions. Population: older adults. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 2unknown: 15benefit: 1harm: 2mixed: 1

PMID 39869458 PMID 42106814 PMID 42476160 PMID 42189540 PMID 41167013 PMID 42081247 PMID 39446325 PMID 42042836 PMID 41609947 PMID 42475253

higher-confidence evidence

COVID-19 Vaccines · multiple reported outcomes

15 studies

Status: apparently conflicting; different clinical questions. Population: influenza A. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 12null: 2harm: 1

PMID 42388750 PMID 42000586 PMID 39786918 PMID 39504023 PMID 40639178 PMID 42492070 PMID 41661551 PMID 41719864 PMID 42468225 PMID 42033452

higher-confidence evidence

Influenza Vaccines · multiple reported outcomes

13 studies

Status: apparently conflicting; different clinical questions. Population: seasonal influenza. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 11benefit: 1harm: 1

PMID 42105399 PMID 42001264 PMID 37591411 PMID 38843267 PMID 39919447 PMID 42010692 PMID 41631848 PMID 42374558 PMID 42297975 PMID 40970590

limited evidence

Influenza Vaccines · multiple reported outcomes

9 studies

Status: apparently conflicting; different clinical questions. Population: seasonal influenza; older adults. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

unknown: 7harm: 1mixed: 1

PMID 38604619 PMID 42320382 PMID 39775353 PMID 42314310 PMID 41848762 PMID 41700988 PMID 42468224 PMID 42550738 PMID 42362565

higher-confidence evidence

Pneumococcal Vaccines · multiple reported outcomes

8 studies

Status: apparently conflicting; different clinical questions. Population: influenza A. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1unknown: 5benefit: 1harm: 1

PMID 42000586 PMID 42397204 PMID 38526550 PMID 41834122 PMID 42322680 PMID 42552681 PMID 42033452 PMID 40716013

moderate-confidence evidence

Influenza Vaccines · multiple reported outcomes

7 studies

Status: apparently conflicting; different clinical questions. Population: influenza A; children. Comparator: multiple or inconsistently reported comparators.

The records use different or inconsistently reported comparators.
The records report different endpoints or outcome definitions.
The evidence combines different study designs.
Some abstracts do not state whether the primary endpoint was met.

null: 1unknown: 5benefit: 1

PMID 39197260 PMID 41962984 PMID 42246636 PMID 39993940 PMID 42008904 PMID 42373575 PMID 41742058

Failed or Negative Trials

Influence of the Olfatín Project on the reduction of pain related to intranasal influenza vaccination, as part of a school influenza vaccination program.

randomized controlled trial · 2024 · PMID 39197260

Influenza vaccination for prevention of death and major cardiovascular events in patients with a history of stroke: A subanalysis of the VIP-ACS trial.

randomized controlled trial · 2026 · PMID 40973981

Pediatric Bronchiectasis Action Management Plan to Improve Clinical Outcomes: A Randomized Controlled Trial.

randomized controlled trial · 2025 · PMID 40930343

Impact of multifaceted health education on influenza vaccination health literacy in primary school students: a cluster randomized controlled trial.

randomized controlled trial · 2025 · PMID 40468328

Exploration of the utility of different doses of Qingfei Dayuan granules: a multicenter, randomized, double-blind, placebo-controlled trial.

randomized controlled trial · 2024 · PMID 38412322

Immunogenicity and safety of live attenuated influenza vaccine in children aged 3-17 years in China.

randomized controlled trial · 2025 · PMID 39729925

Immunogenicity and safety of recombinant influenza vaccine versus standard inactivated influenza vaccine in children aged 3 to 8 years: results from a phase III randomised study.

randomized controlled trial · 2026 · PMID 42000149

Efficacy and safety of onradivir in adults with acute uncomplicated influenza A infection in China: a multicentre, double-blind, randomised, placebo-controlled and oseltamivir-controlled, phase 3 trial.

randomized controlled trial · 2025 · PMID 40489986

Impact of Real-Time, On-Demand Influenza and Respiratory Syncytial Virus Testing at Point-of-Care on Antibiotic Prescribing and Clinical Outcome in Pediatric Outpatients With Acute Respiratory Illness: A Prospective, Quasi-Randomized, Controlled Study.

randomized controlled trial · 2026 · PMID 41474255

Oral Favipiravir Exposure and Pharmacodynamic Effects in Adult Outpatients With Acute Influenza.

randomized controlled trial · 2024 · PMID 37739792

Emerging and Experimental Research

Immunogenicity and safety of MF59-adjuvanted H5N1 pandemic influenza vaccine in healthy infants and children: a phase 2 randomized, observer-blind, multicenter study.

randomized controlled trial · 2026 · PMID 41895156

Efficacy of swine Influenza A virus vaccines on transmission, viral shedding and clinical signs: Systematic review and meta-analysis.

meta analysis · 2026 · PMID 41946219

[Efficacy and safety of pixavir marboxil for uncomplicated influenza in adults: a phase Ⅱ, randomized, double-blind, placebo-controlled clinical trial].

randomized controlled trial · 2026 · PMID 42373447

Immunogenicity and safety of higher-dose cell-based adjuvanted quadrivalent influenza vaccines: Combined results of randomised, controlled dose-finding and dose-confirmation studies.

randomized controlled trial · 2026 · PMID 41855648

Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hemagglutinin with Matrix-M® adjuvant: A phase 1/2 clinical trial.

randomized controlled trial · 2026 · PMID 42390526

Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults.

randomized controlled trial · 2026 · PMID 41627968

Safety and immunogenicity of an investigational mRNA-lipid nanoparticle-based monovalent influenza vaccine: Results from a phase 1, randomized, dose-escalation study.

randomized controlled trial · 2026 · PMID 41701031

Immunogenicity and safety of AS03-adjuvanted A/Astrakhan/3212/2020 (H5N8)-like influenza vaccine in adults: Phase 1/2, observer-blinded, randomized trial.

randomized controlled trial · 2026 · PMID 42274331

A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D.

randomized controlled trial · 2026 · PMID 41211943

A group 1 hemagglutinin stem vaccine elicits broad humoral responses against influenza in phase 1/2a study.

randomized controlled trial · 2026 · PMID 41974675

Evidence Gaps

Detailed risk-of-bias assessment remains limited

PubMed abstracts often do not include enough methodological detail for a complete study-level risk-of-bias assessment.

Complete Ranked PubMed Index

The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.

Current Standard Of Care63 records

Rank112.0

Clinical guideline or consensus statement

[Vaccination Recommendations for the Immunocompromised Adult Patient].

Acta medica portuguesa · 2025 · PMID 41353643

Rank110.0

Clinical guideline or consensus statement

Management of Invasive Pulmonary Aspergillosis in Intensive Care Units: Guidelines From the Fungal Infection Network of Switzerland (FUNGINOS).

Mycoses · 2025 · PMID 41311305

Invasive pulmonary aspergillosis (IPA) is increasingly recognised in intensive care units (ICU) affecting not only patients with classical immunosuppressive conditions but also other severely ill patients, including those with respiratory viral infections (influenza, COVID-19), advanced chronic obstructive pulmonary disease or acute and chronic liver diseases. Several expert panels have proposed definitions of IPA in different ICU settings. However, practical recommendations for its diagnostic and therapeutic appro…

Rank110.0

Clinical guideline or consensus statement

Annals of internal medicine · 2026 · PMID 41248504

Rank110.0

Clinical guideline or consensus statement

Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine.

Pulmonology · 2025 · PMID 39869458

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection, hospitalisation and death in adults. METHODS: Based on evidence regarding the impact of RSV on adult populations at risk for severe infection and the efficacy and safety of RSV vaccines, the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Soc…

Rank110.0

Clinical guideline or consensus statementResult signal: harm

Consensus document on the role of adult vaccination in the prevention of cardiovascular events. Joint Statement by the Argentine Federation of Cardiology (FAC), Argentine Society of Cardiology (SAC), and the Argentine Council of Cardiology Residents (CONAREC).

Medicina · 2026 · PMID 41961609

Cardiovascular diseases remain the leading cause of death among adults, both in Argentina and worldwide. Numerous studies have established a consistent association between infections -particularly respiratory infections- and an increased risk of cardiovascular events, stroke, arrhythmias, and both cardiovascular and all-cause mortality. The underlying pathophysiological mechanisms include systemic inflammation, immune activation, endothelial dysfunction, prothrombotic states, sympathetic stimulation, and elevated m…

Rank110.0

Clinical guideline or consensus statement

Recommendations for Prevention and Control of Influenza in Children, 2025-2026: Technical Report.

Pediatrics · 2025 · PMID 40717224

An integrative meta-analysis of SARS-CoV-2 RNA-protein interactomes identifies conserved host factors shared with other RNA viruses.

Briefings in functional genomics · 2026 · PMID 42149692

RNA viruses cause substantial global disease burden and depend on host RNA-binding proteins and translation machinery. However, it remains unclear which host factors are robustly engaged across independent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA interactome studies and to what extent these factors are shared with other RNA viruses. Here, we perform an integrative meta-analysis of eight published SARS-CoV-2 RNA-protein interactomes and compare them with corresponding Influenza A virus, Zika …

Rank100.0

Systematic review or meta-analysis

How should vaccine hesitancy be measured in healthcare workers? A systematic review of the measurement properties of validated tools.

Human vaccines & immunotherapeutics · 2025 · PMID 40531668

The use of validated tools to assess vaccine hesitancy is essential for designing strategies to improve vaccine uptake among healthcare workers (HCWs). This systematic review identified and evaluated tools measuring knowledge, attitudes, practices, vaccine intentions, and vaccine hesitancy in HCWs. Searches were conducted in PubMed, CINAHL, Scopus, Web of Science, PsycINFO, Cochrane Library, and JBI (PROSPERO: CRD42020212252). The methodological quality of the instruments was determined using the COnsensus-based St…

Rank98.5

Systematic review or meta-analysis

inFLUence: Development of a self-administered risk stratification tool for patients with influenza-like illness using a user-centered approach.

Health informatics journal · 2026 · PMID 41765770

BackgroundInfluenza is often self-limiting but leads to avoidable emergency department visits. This study describes the development of inFLUence, an online self-administered tool for stratifying influenza-like illness risk.MethodsThe tool was developed using a user-centered design approach, informed by a systematic review of existing risk stratification tools. A prototype was iteratively refined across three rapid prototyping cycles with 18 participants and evaluated by seven clinical experts through an online surv…

Rank77.5

Multicenter clinical studyResult signal: null

Empirical Antifungal Treatment of Critically Ⅲ Patients With Influenza-Associated Acute Respiratory Distress Syndrome: A Propensity Score Weighted Observational Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 40971881

BACKGROUND: Influenza-associated pulmonary aspergillosis (IAPA) is a significant fungal complication in patients with influenza-induced acute-respiratory-distress-syndrome (ARDS). The impact of empirical antifungal treatment on IAPA incidence and outcomes remains unclear. METHODS: In this observational multicenter study (9 treatment centers), we included all consecutive patients admitted to intensive care units (ICUs) with influenza-associated ARDS between 1 September 2016 and 1 March 2025. We compared patients rec…

Rank71.1

Prospective cohort study

Factors associated with return-to-sport outcomes following pathogen-confirmed acute respiratory infections in athletes: AWARE X study.

British journal of sports medicine · 2026 · PMID 42321006

OBJECTIVE: To identify factors associated with return-to-sport (RTS) outcomes following confirmed acute respiratory infections (ARinf) in athletes. METHODS: This prospective cohort study included 114 confirmed ARinf cases among athletic individuals. Causative pathogens were identified using multiplex PCR testing, and illness severity was classified per International Olympic Committee consensus (mild, moderate and severe). RTS outcomes included time (days) to return-to-training (RTT), return-to-full-training (RTFT) …

Rank50.3

Other PubMed-indexed publication

Clinical and epidemiological characteristics of respiratory syncytial virus, SARS-CoV-2 and influenza paediatric viral respiratory infections in southwest Saudi Arabia.

Annals of medicine · 2025 · PMID 39717000

BACKGROUND: There is a global consensus that respiratory tract infections are the major causes of morbidity and mortality among children. In this study, we aimed to compare the clinical and epidemiological characteristics of respiratory syncytial virus (RSV), influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among children admitted to hospital with acute respiratory infections. We also opted to identify the predictors of paediatric intensive care unit (PICU) admission. METHODS: I…

Rank49.5

Other PubMed-indexed publication

Strengthening India's pandemic preparedness with the four zonal institutes of virology: stakeholder consultations for outbreak response and collaborative research priorities.

Infectious diseases of poverty · 2026 · PMID 42522023

BACKGROUND: The Pradhan Mantri Ayushman Bharat Health Infrastructure Mission (PM-ABHIM) scheme, supported by the World Bank, is establishing four zonal National Institutes of Virology (NIVs) in India. It is essential to identify the zonal disease and research priorities so as to focus research at zonal levels. This study reports a zonal viral disease prioritisation exercise to support outbreak response and collaborative research. It describes zonal-prioritised viral diseases, assesses concordance and differences in…

Rank48.9

Other PubMed-indexed publicationResult signal: null

Comparing 2-day vs 3-day flu-CY lymphodepleting regimens for CD19 CAR T-cell therapy in patients with non-hodgkin's lymphoma.

Frontiers in immunology · 2024 · PMID 38947326

INTRODUCTION: Lymphodepleting chemotherapy (LDC) is critical to CAR T-cell expansion and efficacy. Despite this, there is not a consensus in the literature regarding the optimal LDC regimen, including dose and frequency. METHODS: We retrospectively reviewed consecutive patients at a single institution that received LDC prior to treatment with the CD19 directed CAR T-cell products axicabtagene ciloleucel and tisagenlecleucel. Patients treated at our center received fludarabine 30 mg/m2 and cyclophosphamide 500 mg/m2…

Rank48.0

Other PubMed-indexed publication

Implications of cytokines in Memory B cell for risk stratification and therapeutic framework construction among Pediatric Influenza patents: insights from machine learning and multi-omics.

Computational biology and chemistry · 2026 · PMID 41775124

OBJECTIVE: Cytokine storm and dysregulation of Memory B cell aggravate the symptoms and weaken the therapeutic effectiveness for Pediatric Influenza(PI) patents. Hence, deeper understanding of Integration cytokines and memory B cell can pave the way for the treatment of PI. METHODS: By integration of 2 peripheral blood bulk profiles of PI patients(GSE29366 and GSE42026) and integrative bioinformatic analysis, including CIBERSORT, WGCNA, Limma and 3 machine learning algorithms(RF, Lasso and SVM-RFE), we creatively i…

Diagnosis And Screening351 records

Rank110.0

Clinical guideline or consensus statement

[Clinical practice guidelines for the management of influenza in adults with chronic airway diseases].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases · 2026 · PMID 42108174

Rank110.0

Systematic review or meta-analysis

Optimizing Intubation Prediction in Pneumonia Patients: A Systematic Review and Meta-Analysis of Machine Learning Algorithms.

Pulmonary medicine · 2026 · PMID 41848079

Rank109.2

Systematic review or meta-analysis

Traditional Chinese Medicine for preventing influenza: a systematic review and meta-analysis.

Frontiers in medicine · 2026 · PMID 42110432

BACKGROUND: Influenza is an acute infectious respiratory disease causing substantial public health and economic burdens. Multiple clinical studies have investigated traditional Chinese medicine (TCM) for influenza prevention. OBJECTIVE: To assess the effectiveness and safety of TCM preventive interventions against influenza through direct comparisons. METHODS: We systematically searched PubMed, EMbase, CENTRAL, Web of Science, CNKI, WanFang, CQVIP, and Sinomed up to August 14, 2025. A two-stage screening process (t…

Rank106.1

Systematic review or meta-analysisResult signal: null

Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.

Stem cell research & therapy · 2026 · PMID 42035205

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can induce immune dysregulation and multi-organ injury; mesenchymal stromal cell (MSC) therapy has shown promise in clinical trials for COVID-19 and may have broader applicability to pneumonia induced by respiratory viruses (e.g., the influenza virus). This meta-analysis synthesized the available comparative clinical evidence on the safety and efficacy of MSCs in patients with moderate to critical COVID-19 and examined the reported o…

Rank105.9

Systematic review or meta-analysis

Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis.

The lancet. Healthy longevity · 2026 · PMID 42476160

BACKGROUND: The comparative efficacy and safety of high-dose inactivated influenza vaccine (HD-IIV) versus standard-dose inactivated influenza vaccine (SD-IIV) in adults 65 years or older remain uncertain. Hence, we aimed to compare the effects of HD-IIV versus those of SD-IIV for hospitalisation and mortality outcomes in this population by synthesising evidence from randomised controlled trials (RCTs). METHODS: In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register …

Rank105.8

Systematic review or meta-analysisResult signal: null

Efficacy and Safety of Bendamustine Versus Fludarabine and Cyclophosphamide as Lymphodepleting Regimens for CAR-T Therapy in Hematological Malignancies: A Systematic Review and Meta-Analysis.

European journal of haematology · 2026 · PMID 42063324

OBJECTIVES: Chimeric antigen receptor T-cell (CAR-T) therapy has become an established treatment for hematological malignancies. Lymphodepleting (LD) chemotherapy is a preparatory step that facilitates CAR-T cell expansion and persistence. While fludarabine and cyclophosphamide (Flu/Cy) are a standard LD regimen, bendamustine has emerged as a potential alternative. METHODS: We performed a systematic review and meta-analysis comparing the efficacy and safety of bendamustine versus Flu/Cy as LD regimens. We systemati…

Rank104.1

Systematic review or meta-analysis

Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.

European respiratory review : an official journal of the European Respiratory Society · 2026 · PMID 41951240

BACKGROUND: Respiratory viruses, frequently detected in asthma, are associated with worse outcomes. This meta-analysis systematically quantifies the prevalence of respiratory viruses in stable and acute asthma, across children and adults, and explores factors associated with increased viral burden through meta-regression. METHODS: This prospectively registered meta-analysis (PROSPERO-CRD42023375108) included studies employing molecular techniques to assess respiratory virus prevalence in asthma. Three databases wer…

Rank103.2

Systematic review or meta-analysis

Patterns of Avian Influenza Virus detection from active surveillance in wild birds: A systematic review and meta-analysis.

One health (Amsterdam, Netherlands) · 2026 · PMID 41716774

We summarised active surveillance data to identify patterns and ecological factors correlated with AIV detection in wild birds, through a systematic review and meta-analysis. We screened 2851 articles from the PubMed and Scopus databases, out of which 197 met our eligibility criteria and were selected for further analysis. The dataset encompassed 367 wild bird species from 72 avian families. The pooled prevalence of sampled birds was 4.80% (95% CI: [3.91-5.77%]) across 900,469 samples collected during the period 19…

Rank102.6

Systematic review or meta-analysis

Clinical impact of rapid molecular diagnostic tests in patients presenting with viral respiratory symptoms: A systematic literature review.

PloS one · 2024 · PMID 38870136

BACKGROUND: Molecular tests can detect lower concentrations of viral genetic material over a longer period of respiratory infection than antigen tests. Delays associated with central laboratory testing can result in hospital-acquired transmission, avoidable patient admission, and unnecessary use of antimicrobials, all which may lead to increased cost of patient management. The aim of this study was to summarize comparisons of clinical outcomes associated with rapid molecular diagnostic tests (RMDTs) versus other di…

Rank101.6

Systematic review or meta-analysis

A systematic review to understand the long-term mental health effects of influenza pandemics.

Scandinavian journal of public health · 2026 · PMID 41320943

AIMS: Health effects of pandemics extend beyond morbidity and mortality from the disease itself and may include long-term mental health consequences. However, previous studies only consider narrowly defined populations at risk or examine pandemics caused by varied pathogens that may have inconsistent effects. We examine existing literature on these long-term mental health effects following one type of pandemic (influenza). METHODS: We conducted a systematic review of the long-term mental health effects of the 1889,…

Rank101.2

Randomized controlled trialResult signal: benefit

Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults.

The New England journal of medicine · 2026 · PMID 42090792

BACKGROUND: Seasonal influenza causes substantial illness and death in adults 50 years of age or older, even with current vaccines. An investigational messenger RNA (mRNA)-based vaccine called mRNA-1010 encodes hemagglutinin glycoproteins from World Health Organization-recommended influenza strains. METHODS: In this phase 3, double-blind, active-controlled trial, we randomly assigned adults 50 years of age or older to receive trivalent mRNA-1010 (37.5 μg, which includes 12.5 μg of each strain) or a licensed standar…

Rank100.0

Systematic review or meta-analysisResult signal: harm

Systematic review and meta-analysis of respiratory viral triggers for acute myocardial infarction and stroke.

Cardiovascular research · 2025 · PMID 40570137

Respiratory viral infections may trigger acute cardiovascular events. However, relative pathogen-specific associations are poorly understood, limiting optimal preventive recommendations. The aim of this study was to systematically review the association between respiratory viruses with two primary outcomes, acute myocardial infarction (AMI) and stroke. We searched MEDLINE, PubMed, Embase, Cochrane, and Web of Science, from database inception to 26 August 2024. Analytical epidemiological studies of respiratory virus…

Rank100.0

Systematic review or meta-analysis

Efficacy of swine Influenza A virus vaccines on transmission, viral shedding and clinical signs: Systematic review and meta-analysis.

Preventive veterinary medicine · 2026 · PMID 41946219

Swine influenza A viruses (swIAV) are a major cause of respiratory disease in pigs, and vaccination remains the main control strategy. The objective of this systematic review and meta-analysis was to quantify the efficacy of swIAV vaccines in pigs, regarding viral transmission, viral shedding and clinical signs. Data were extracted from experimental studies involving vaccinated pigs subsequently challenged with swIAV. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) gu…

Rank99.0

Systematic review or meta-analysis

Infection-Associated Pediatric Acute-Onset Neuropsychiatric Syndrome: A Review of Immunological Mechanisms, Clinical Phenotypes, and Therapeutic Strategies.

Infectious disease reports · 2026 · PMID 42496299

BACKGROUND/OBJECTIVES: Pediatric acute-onset neuropsychiatric syndrome (PANS) describes the rapid onset of obsessive-compulsive symptoms or severe food restriction, accompanied by neuropsychiatric or somatic features that are not better explained by another disorder. PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) is a related, more narrowly defined construct in which symptoms are temporally associated with group A Streptococcus infection. This review examines clini…

Rank98.0

Systematic review or meta-analysis

Generating the evidence to support the establishment of a Respiratory Syncytial Virus surveillance system in Cameroon: A study protocol.

PloS one · 2024 · PMID 38861519

BACKGROUND: Respiratory syncytial virus (RSV) is one of the major pathogens frequently associated with severe respiratory tract infections in younger children and older adults globally. There is an unmet need with a lack of routine country-specific databases and/or RSV surveillance systems on RSV disease burden among adults in most low- and middle-income countries, including Cameroon. We aim to estimate the adult RSV burden needed to develop a framework for establishing an RSV surveillance database in Cameroon. MET…

Rank96.0

Systematic review or meta-analysis

Malaria Coinfections Worldwide: An Umbrella Systematic Review of Prevalence and Epidemiological Patterns.

Tropical medicine and infectious disease · 2026 · PMID 42506776

Malaria coinfections with other infectious agents represent a clinically relevant epidemiological challenge, but evidence remains fragmented across individual systematic reviews. This umbrella systematic review synthesized review-level evidence on the prevalence and epidemiological patterns of concurrent malaria coinfections in human populations. PubMed/MEDLINE, Scopus, Web of Science, Embase, and LILACS/BVS were searched for systematic reviews published from 1 January 2000 to March 2026. Risk of bias, certainty of…

Rank96.0

Systematic review or meta-analysis

Rhaponticum genus: a systematic review on traditional uses, phytochemical profiles and pharmacological activities.

Frontiers in pharmacology · 2026 · PMID 42100310

BACKGROUND: The genus Rhaponticum (Asteraceae/Compositae) comprises 24 species worldwide and has long been utilized in traditional medicine for clearing heat, detoxification, relieving intestinal colic, and treating rheumatoid arthritis, neurasthenia, kidney deficiency, lumbago, and gastrointestinal disorders. Modern pharmacological studies have revealed its diverse bioactivities, including antihypertensive, hypolipidemic, immunomodulatory, neuroprotective, antitumor, hepatoprotective, cardioprotective, anti-inflam…

Rank96.0

Systematic review or meta-analysis

"Can a chatbot be used in the full-text screening in a systematic review?".

International journal of medical informatics · 2026 · PMID 41950629

INTRODUCTION: Large language model-based artificial intelligence tools are increasingly explored to support systematic reviews, yet evidence regarding their reliability in full-text screening remains limited. This study evaluated the performance of two versions of ChatGPT (4.0 and 5.0) compared with human reviewers during article selection for a systematic review on influenza vaccine effectiveness. METHODS: A total of 170 full-text articles were independently assessed for eligibility using predefined inclusion and …

Rank96.0

Systematic review or meta-analysis

Post vaccination acute kidney injury and other renal complications after COVID-19 and influenza vaccination.

World journal of nephrology · 2026 · PMID 42395659

BACKGROUND: Vaccination remains a cornerstone of public health, yet concerns regarding serious adverse events continue to contribute to vaccine hesitancy. While systemic and local vaccine reactions are well described, renal complications such as acute kidney injury (AKI) and immune-mediated glomerular disease are less well characterised. With widespread and sustained use of coronavirus disease 2019 (COVID-19) and influenza vaccines, a comprehensive synthesis of reported renal adverse outcomes is needed. AIM: To syn…

Rank96.0

Systematic review or meta-analysisResult signal: harm

Antibiotic Use, Bacterial Co-Infection, and Antimicrobial Resistance in Adults Hospitalized with COVID-19, Influenza, or RSV: A Systematic Review and Meta-Analysis.

Antibiotics (Basel, Switzerland) · 2026 · PMID 42505617

BACKGROUND: Adults hospitalized with COVID-19, influenza A/B, or respiratory syncytial virus (RSV) frequently receive empirical antibiotics, but antibiotic prescribing, confirmed bacterial co-infection, antimicrobial resistance (AMR), and outcomes have not been jointly synthesized across these infections. METHODS: We conducted a PRISMA 2020 systematic review and meta-analysis of 39 studies including 839,531 hospitalized adults. Random-effects models with Freeman-Tukey double-arcsine transformation pooled prevalence…

Rank92.0

Randomized controlled trial

Improved diagnostic management of children with acute infections following the introduction of point-of-care C-reactive protein testing and general practitioner education in Latvia: a post hoc analyses of a randomised controlled intervention study.

Scandinavian journal of primary health care · 2026 · PMID 41162196

OBJECTIVE: In order to reduce unnecessary antibiotic prescribing, diagnostic processes require improvement for children in primary care. DESIGN: Post hoc analyses of randomised controlled intervention study. SETTING: Eighty general practitioner (GP) practices throughout Latvia. INTERVENTION: In the first study period, one GP group received combined interventions (access to CRP POCT and GP education), while the second GP group continued usual care (control group). In the second study period, the GP groups were switc…

Rank90.8

Randomized clinical study

TREATment of Lower Respiratory Tract Infection in Selected Hospitals in Southern Sri Lanka (TREAT-SL): study protocol for a stepped-wedge, cluster-randomized clinical trial.

Trials · 2026 · PMID 41851897

BACKGROUND: Lower respiratory tract infection (LRTI) is a leading cause of hospitalization and antibacterial use globally. In low- and middle-income countries (LMICs), limited diagnostic resources contribute to inappropriate antibacterial use for LRTI. The aim of this trial is to determine the impact of an electronic clinical decision support tool (eCDST) on LRTI management in Southern Sri Lanka. METHODS: This is a prospective, open-label, stepped-wedge, cluster-randomized trial that will be conducted at three publ…

Rank89.5

Randomized clinical study

Primed to feel, not to flare: Early life adversity and psychological sensitivity to interleukin-6 in a randomized trial among middle-aged female breast cancer survivors.

Brain, behavior, and immunity · 2026 · PMID 42526663

BACKGROUND: There have been recent calls to investigate potential moderators of inflammation's psychological effects in humans. In a small observational study, Kuhlman et al. (2020b) found that individuals with higher early life adversity (ELA) showed heightened psychological sensitivity (i.e., more depressed mood and poorer cognition but not decreased social connection) in response to influenza vaccine-induced increases in interleukin-6 (IL-6). In a larger cohort with a placebo-controlled experimental design, we e…

Rank88.0

Randomized clinical study

Antibiotic therapy in viral airway infections (ATHENIAN): study protocol for an open labeled randomized controlled pragmatic trial to evaluate the efficacy and safety of discontinuing antibiotic therapy in adult patients infected with respiratory viruses.

Trials · 2026 · PMID 42015169

BACKGROUND: Reducing inappropriate use of antibiotics is essential to combat antimicrobial resistance. Antibiotics are widely prescribed upon hospital admission for acute respiratory infections, but it remains unknown whether it is safe to discontinue antibiotics when a respiratory virus is detected in these patients. With this randomized trial, we aim to assess the efficacy and safety of discontinuing antibiotic therapy in patients admitted to the hospital with a polymerase chain reaction test positive for respira…

Rank85.0

Randomized clinical study

Research progress on the association between viruses and cardiac diseases.

Journal of virology · 2026 · PMID 42262130

Virus-related cardiac diseases encompass a diverse spectrum of cardiovascular pathologies caused by direct viral infection and indirect immune-mediated injury. Major cardiotropic and cardioactive viruses-including severe acute respiratory syndrome coronavirus 2, influenza virus, human immunodeficiency virus, arboviruses (dengue virus, chikungunya virus, Zika virus), enteroviruses (coxsackievirus B3), and human cytomegalovirus-contribute to myocardial injury manifesting as myocarditis, pericarditis, arrhythmias, acu…

Factors influencing the relationship between influenza vaccination and the risk of developing dementia: A systematic review.

Journal of Alzheimer's disease : JAD · 2026 · PMID 41736221

BackgroundDementia is a leading cause of mortality worldwide, with its prevalence projected to rise sharply in the coming decades. Established risk factors include advanced age, hypertension, diabetes, obesity, smoking, excessive alcohol consumption, physical inactivity, social isolation, and depression. Increasing evidence suggests that vaccination-by preventing infections that may trigger or accelerate neurodegeneration-could play a protective role against dementia, though findings remain inconsistent.ObjectiveTo…

Rank109.0

Systematic review or meta-analysis

Epidemiological and Evolutionary Dynamics of Dengue Virus in Saudi Arabia: Insights from Three Decades of Molecular and Serological Surveillance.

International journal of molecular sciences · 2026 · PMID 42450282

Dengue fever represents a significant public health challenge in Saudi Arabia, yet comprehensive molecular characterization of circulating serotypes remains limited. This study combines epidemiological and phylogenetic analyses to understand dengue virus (DENV) dynamics in the Kingdom. A systematic review and meta-analysis of dengue epidemiological data from Saudi Arabia (1992-2026) was the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All available DENV envelope (E) gene s…

Rank107.9

Systematic review or meta-analysis

Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.

The Cochrane database of systematic reviews · 2025 · PMID 40013540

RATIONALE: People who work in long-term care institutions (LTCIs), such as doctors, nurses, other health professionals, cleaners and porters (and also family visitors), may have substantial rates of influenza during influenza seasons. They often continue to work when infected with influenza, increasing the likelihood of transmitting influenza to those in their care. The immune systems of care home residents may be weaker than those of the general population; vaccinating care home workers could reduce transmission o…

Rank107.7

Systematic review or meta-analysis

A Systematic Review and Meta-Analysis of Immunogenicity and Safety of the Influenza Vaccine in COPD Patients, and Its Relevance with Real-World Effectiveness.

International journal of chronic obstructive pulmonary disease · 2026 · PMID 41939928

OBJECTIVE: A systematic review and meta-analysis was conducted to evaluate the immunogenicity and adverse events of influenza vaccines in patients with chronic obstructive pulmonary disease (COPD) and explored their relevance to real-world vaccine effectiveness (VE). METHODS: A systematic search of PubMed, Cochrane Library (Wiley), Google Scholar, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform using keywords of "influenza vaccine", "immunogenicity", "COPD", and "Chronic Obstructive P…

Rank106.1

Systematic review or meta-analysisResult signal: null

Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.

Stem cell research & therapy · 2026 · PMID 42035205

Rank106.0

Systematic review or meta-analysisResult signal: harm

Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Transplantation and cellular therapy · 2026 · PMID 41349636

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for many hematological malignancies. The busulfan plus cyclophosphamide (Bu/Cy) combination is a standard myeloablative conditioning (MAC) regimen, but it is associated with significant regimen-related toxicity and non-relapse mortality (NRM). To mitigate these issues, a regimen combining high-dose busulfan with fludarabine (Bu/Flu) was developed, aiming to reduce toxicity while preserving efficacy. While a previous meta-analysis…

Rank105.9

Systematic review or meta-analysis

Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis.

The lancet. Healthy longevity · 2026 · PMID 42476160

Rank105.8

Systematic review or meta-analysisResult signal: null

Efficacy and Safety of Bendamustine Versus Fludarabine and Cyclophosphamide as Lymphodepleting Regimens for CAR-T Therapy in Hematological Malignancies: A Systematic Review and Meta-Analysis.

European journal of haematology · 2026 · PMID 42063324

Rank105.8

Systematic review or meta-analysis

Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review.

Journal of translational medicine · 2026 · PMID 41668172

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID share clinical features including persistent fatigue, post-exertional malaise (PEM), and gastrointestinal (GI) dysfunction. Growing evidence implicates brain-gut axis dysregulation, characterized by dysbiosis, neuroinflammation within the central nervous system (CNS), increased intestinal permeability, and microbial translocation in their pathophysiology. However, therapeutic strategies targeting these pathways remain poorly defi…

Rank105.2

Systematic review or meta-analysis

Metabolic Effects of Modified-Release Hydrocortisone Versus Short Acting Conventional Oral Glucocorticoids in Adrenal Insufficiency: A Systematic Review and Meta-Analysis.

Clinical endocrinology · 2026 · PMID 42050347

OBJECTIVE: Adrenal insufficiency's (AI) lifelong replacement therapy by conventional glucocorticoid (GC) regimens poorly mimics physiological cortisol, leading to poor adherence and metabolic abnormalities. Modified-release hydrocortisone (MR-HC) provides a more physiological cortisol replacement with potentially enhanced outcomes. This study assessed comparative evidence of MR-HC versus GC in patients with AI. DESIGN: Systematic review and meta-analysis. METHODS: Comparative articles published until July 2025 were…

Rank104.3

Systematic review or meta-analysis

Bidirectional associations between influenza and COVID-19 vaccination: a systematic review and meta-analysis.

Frontiers in public health · 2026 · PMID 42388750

PURPOSE: This study aimed to investigate the effect of vaccination history on future willingness or behavior to receive vaccinations for influenza and COVID-19. METHODS: In this systematic review and meta-analysis, the PubMed, Embase, Web of Science, Cochrane Library, APA PsycInfo, CINAHL and Scopus databases were searched up to February 28, 2026, to identify relevant studies in accordance with the inclusion and exclusion criteria. The analysis ultimately included 145 population-based studies conducted in the Unite…

Rank104.1

Systematic review or meta-analysis

Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.

European respiratory review : an official journal of the European Respiratory Society · 2026 · PMID 41951240

Rank104.1

Systematic review or meta-analysis

Relevance of social contact definitions for use in infectious disease transmission modeling: a systematic review and recommendations.

BMC infectious diseases · 2026 · PMID 41851644

BACKGROUND: Social mixing studies provide crucial evidence for parameterizing mathematical models of infectious disease transmission, and their validity for use in models is dependent on their study design and how well the contacts they capture map to the transmission routes of the pathogen of interest. This systematic review aims to catalogue contact definitions used in social mixing studies from 2005 to 2024 and evaluate their conceptual alignment to three archetypal pathogens. METHODS: We searched Ovid Medline, …

Rank104.0

Systematic review or meta-analysis

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis.

JAMA network open · 2026 · PMID 42189540

IMPORTANCE: High-dose inactivated influenza vaccine (HD-IIV) was developed to enhance immune responses in older adults and has demonstrated superior protection against laboratory-confirmed influenza (LCI) and severe outcomes vs standard-dose inactivated influenza vaccine (SD-IIV). A comprehensive meta-analysis of recent large-scale trials is warranted. OBJECTIVE: To synthesize all evidence from randomized clinical trials comparing HD-IIV with SD-IIV for prevention of hospitalization events and mortality in older ad…

Rank102.6

Systematic review or meta-analysis

Clinical impact of rapid molecular diagnostic tests in patients presenting with viral respiratory symptoms: A systematic literature review.

PloS one · 2024 · PMID 38870136

Rank102.6

Systematic review or meta-analysisResult signal: harm

First trimester maternal infections and offspring congenital heart defects: a meta-analysis.

European heart journal · 2026 · PMID 40878857

BACKGROUND AND AIMS: Maternal infections have been proposed to play a role in the development of congenital heart defects (CHD). This study aims to synthesize contemporary evidence on the association between first-trimester maternal infection and risk of offspring CHD. METHODS: This systematic review and meta-analysis (PROSPERO number: CRD42024523638) used Embase, PubMed, Web of Science, Scopus, and the Cochrane Library to identify studies investigating first-trimester maternal infection and offspring CHD, publishe…

Rank102.0

Systematic review or meta-analysis

Emerging trends and hotspots in Oseltamivir resistance: insights from a bibliometric investigation.

Naunyn-Schmiedeberg's archives of pharmacology · 2026 · PMID 41571900

Influenza has long been a serious global public health problem, and the risk of drug resistance to Oseltamivir, as a first-line antiviral drug, cannot be ignored. Although some research findings have been published, a systematic review of current research on Oseltamivir resistance is lacking. Therefore, we employed a bibliometric method to conduct comprehensive search and to present current trends. Based on the screening criteria, literature related to Oseltamivir resistance from 2000 To 2024 was retrieved from the…

Rank102.0

Systematic review or meta-analysis

Eupatorium fortunei Turcz.: An Updated Review on the Botany, Phytochemistry, Pharmacology, and Toxicology.

Molecules (Basel, Switzerland) · 2026 · PMID 41976178

Eupatorium fortunei Turcz. (E. fortunei), a member of the Asteraceae family, is a widely utilized traditional medicinal herb in China. Historically, it has been employed to treat conditions such as influenza, nausea, anorexia, and various ailments associated with "pathogenic dampness". To the best of our knowledge, this study presents the first systematic review of recent research on E. fortunei, based on a comprehensive literature search across both Chinese and international databases, including Web of Science, Pu…

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2024 · PMID 39197095

This report updates the 2023-24 recommendations of the Advisory Committee on Immunization Practices (ACIP) concerning the use of seasonal influenza vaccines in the United States (MMWR Recomm Rep 2022;72[No. RR-2]:1-24). Routine annual influenza vaccination is recommended for all persons aged ≥6 months who do not have contraindications. Trivalent inactivated influenza vaccines (IIV3s), trivalent recombinant influenza vaccine (RIV3), and trivalent live attenuated influenza vaccine (LAIV3) are expected to be available…

Rank110.0

Clinical guideline or consensus statement

Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP): Recommended Immunization Schedule (2025) and Update on Immunization for Children Aged 0 Through 18 Years.

Indian pediatrics · 2026 · PMID 41954836

Rank109.0

Systematic review or meta-analysis

Epidemiological and Evolutionary Dynamics of Dengue Virus in Saudi Arabia: Insights from Three Decades of Molecular and Serological Surveillance.

International journal of molecular sciences · 2026 · PMID 42450282

Rank107.9

Systematic review or meta-analysis

Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.

The Cochrane database of systematic reviews · 2025 · PMID 40013540

Rank107.7

Systematic review or meta-analysis

A Systematic Review and Meta-Analysis of Immunogenicity and Safety of the Influenza Vaccine in COPD Patients, and Its Relevance with Real-World Effectiveness.

International journal of chronic obstructive pulmonary disease · 2026 · PMID 41939928

Rank106.4

Systematic review or meta-analysisResult signal: harm

Determinants of poor clinical outcome in patients with influenza pneumonia: A systematic review and meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023 · PMID 37030656

BACKGROUND: The clinical burden of influenza is increasing worldwide. Aging, immunosuppression, and underlying respiratory illness are determinants of poor clinical outcomes, including greater mortality. Bacterial infections seem to be the main reason. Updated information on the role of bacterial infection as the cause of complications would be of value in improving the prognosis of patients with influenza. METHODS: A systematic review and meta-analysis were performed by using the PubMed repository using keywords l…

Rank106.3

Systematic review or meta-analysis

Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials.

Lancet (London, England) · 2024 · PMID 39181595

BACKGROUND: The optimal antiviral drug for treatment of severe influenza remains unclear. To support updated WHO influenza clinical guidelines, this systematic review and network meta-analysis evaluated antivirals for treatment of patients with severe influenza. METHODS: We systematically searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, Global Health, Epistemonikos, and ClinicalTrials.gov for randomised controlled trials published up…

Rank106.1

Systematic review or meta-analysisResult signal: null

The impact of obesity on influenza Vaccine immunogenicity: A systematic review.

Vaccine · 2025 · PMID 41033261

BACKGROUND: Influenza vaccines are important for reducing the burden of influenza, particularly for populations at risk of more severe infections. Obesity is associated with increased influenza severity and therefore individuals with obesity are often specifically recommended for annual influenza vaccination. Obesity is also associated with an altered inflammatory profile, which may influence vaccine responses. This systematic review aimed to evaluate the evidence for any association between obesity and influenza v…

Rank106.1

Systematic review or meta-analysisResult signal: null

Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.

Stem cell research & therapy · 2026 · PMID 42035205

Rank105.9

Systematic review or meta-analysis

Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis.

The lancet. Healthy longevity · 2026 · PMID 42476160

Rank105.9

Systematic review or meta-analysis

Trivalent and quadrivalent seasonal influenza vaccine in adults aged 60 and older: a systematic review and network meta-analysis.

BMJ evidence-based medicine · 2024 · PMID 38604619

OBJECTIVES: To compare the efficacy of influenza vaccines of any valency for adults 60 years and older. DESIGN AND SETTING: Systematic review with network meta-analysis (NMA) of randomised controlled trials (RCTs). MEDLINE, EMBASE, JBI Evidence-Based Practice (EBP) Database, PsycINFO, and Cochrane Evidence -Based Medicine database were searched from inception to 20 June 20, 2022. Two reviewers screened, abstracted, and appraised articles (Cochrane Risk of Bias (ROB) 2.0 tool) independently. We assessed certainty of…

Rank105.8

Systematic review or meta-analysis

Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review.

Journal of translational medicine · 2026 · PMID 41668172

Rank105.8

Systematic review or meta-analysis

Influenza vaccine outcomes: a meta-analysis revealing morbidity benefits amid low infection prevention.

European respiratory review : an official journal of the European Respiratory Society · 2025 · PMID 39778922

BACKGROUND: The morbidity and mortality associated with influenza viruses are a significant public health challenge. Annual vaccination against circulating influenza strains reduces hospitalisations and increases survival rates but requires a yearly redesign of vaccines against prevalent subtypes. The complex genetics of influenza viruses with high antigenic drift create an ongoing challenge in vaccine development to address dynamic influenza epidemiology. Understanding the evolution of influenza viruses and the va…

Rank105.2

Systematic review or meta-analysis

Impact of educational interventions on the prevention of influenza: A systematic review.

Frontiers in public health · 2022 · PMID 36203669

INTRODUCTION: Seasonal influenza, a contagious viral disease affecting the upper respiratory tract, circulates annually, causing considerable morbidity and mortality. The present study investigates the effectiveness of educational interventions to prevent influenza. METHODS: We searched PubMed/Medline, Embase, and Cochrane Controlled Register of Trials (CENTRAL) for relevant clinical studies up to March 1 2022. The following terms were used: "influenza," "flu," "respiratory infection," "prevent," "intervention," an…

Rank105.2

Systematic review or meta-analysis

Metabolic Effects of Modified-Release Hydrocortisone Versus Short Acting Conventional Oral Glucocorticoids in Adrenal Insufficiency: A Systematic Review and Meta-Analysis.

Clinical endocrinology · 2026 · PMID 42050347

Rank105.0

Systematic review or meta-analysis

Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis.

JAMA internal medicine · 2025 · PMID 39804622

IMPORTANCE: The optimal antiviral drug for treatment of nonsevere influenza remains unclear. OBJECTIVE: To compare effects of antiviral drugs for treating nonsevere influenza. DATA SOURCES: MEDLINE, Embase, CENTRAL, CINAHL, Global Health, Epistemonikos, and ClinicalTrials.gov were searched from database inception to September 20, 2023. STUDY SELECTION: Randomized clinical trials comparing direct-acting influenza antiviral drugs to placebo, standard care, or another antiviral drug for treating people with nonsevere …

Rank104.6

Systematic review or meta-analysis

Real-world effectiveness of seasonal influenza vaccination and age as effect modifier: A systematic review, meta-analysis and meta-regression of test-negative design studies.

Vaccine · 2024 · PMID 38423813

BACKGROUND: Under the global risk of epidemic rebound of influenza after COVID-19 outbreak, the study aimed to provide a comprehensive evaluation of the seasonal influenza vaccine effectiveness (IVE) and to explore the potential effect modifiers. METHODS: We searched for test-negative design studies with IVE estimates published between January 1, 2017 and December 31, 2022. We estimated pooled IVE using random-effects meta-analysis, and conducted meta-regression with study site, age, sex and comorbidity as explanat…

Rank104.3

Systematic review or meta-analysis

Bidirectional associations between influenza and COVID-19 vaccination: a systematic review and meta-analysis.

Frontiers in public health · 2026 · PMID 42388750

Rank104.1

Systematic review or meta-analysis

Relevance of social contact definitions for use in infectious disease transmission modeling: a systematic review and recommendations.

BMC infectious diseases · 2026 · PMID 41851644

Rank104.1

Systematic review or meta-analysis

Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.

Funding and geographical distribution of clinical trials in infectious diseases.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 · PMID 41022352

OBJECTIVES: The objective of this study was to map the funding flows in infectious disease randomized clinical trials (RCTs) by examining the relationships between funding sources and trial locations in high-impact journals. METHODS: We conducted a secondary analysis of a previously published systematic review of 1343 infectious disease RCTs published (2014-2023) in ten selected high-impact English-language general medicine and infectious disease journals. Funding source, study site, and disease focus were extracte…

Rank102.0

Systematic review or meta-analysis

Systematic review or meta-analysisResult signal: harm

Co-managing the double burden: strategies for simultaneously tackling infectious and non-communicable diseases.

Infectious diseases of poverty · 2026 · PMID 42538553

Rank100.0

Systematic review or meta-analysisResult signal: null

A systematic meta-analytic comparative evaluation of seasonal influenza vaccine effectiveness from test-negative design studies in the Northern Hemisphere pre/post COVID-19 pandemic.

Vaccine · 2026 · PMID 42486051

BACKGROUND: Influenza circulation was substantially reduced during the COVID-19 pandemic. The consequent reduction in population immunity may have resulted in increased influenza vaccine effectiveness (VE) after the pandemic via reduced immunity in unvaccinated individuals compared to the pre-pandemic period. METHODS: We systematically reviewed published peer-reviewed test-negative design (TND) studies of seasonal influenza VE against medically-attended, laboratory-confirmed influenza in the Northern Hemisphere. We…

Rank100.0

Systematic review or meta-analysis

Coadministration of respiratory syncytial virus (RSV) and seasonal influenza vaccines can increase vaccination uptake. mRNA-1345 (mRESVIA, Moderna, Inc.) is indicated in multiple countries for prevention of RSV-lower respiratory tract disease in adults. This randomized, observer-blind, phase 3 study evaluated safety, tolerability, immunogenicity, and inferred efficacy of mRNA-1345 when coadministered with quadrivalent influenza vaccine-high dose (QIV-HD). Adults ≥65 y (n = 1900) were randomly assigned 1:1 to receiv…

Rank97.7

Randomized controlled trial

Aglatimagene besadenovec (CAN-2409) with radiotherapy for patients with localised prostate cancer: a phase 3, multicentre, randomised, double-blind, placebo-controlled trial.

The Lancet. Oncology · 2026 · PMID 42225101

BACKGROUND: About 30% of men with localised prostate cancer undergoing radiotherapy with curative intent have disease recurrence associated with progression-related symptoms and substantial toxicity of salvage therapies. Previous studies with aglatimagene besadenovec (CAN-2409, hereafter referred to as aglatimagene) showed synergy with radiation and immune-mediated cytotoxicity in patients with prostate cancer. We aimed to assess whether addition of aglatimagene plus prodrug (valacyclovir) to standard-of-care exter…

Preclinical Research318 records

Rank96.0

Systematic review or meta-analysis

From Pandemic Innovation to Platform Diversification: A Systematic Review of Clinical and Preclinical Development of Non-SARS-CoV-2 mRNA Vaccines.

Diseases (Basel, Switzerland) · 2026 · PMID 42505558

Background: Messenger RNA (mRNA) vaccines have emerged as a versatile platform beyond SARS-CoV-2, with expanding applications in infectious diseases and oncology. However, comprehensive evidence synthesis of non-SARS-CoV-2 mRNA vaccines remains limited. Methods: This systematic review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD420261323500). MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, and WHO ICTRP were systematically searched for studies published between 1 January 2000 and…

Rank96.0

Systematic review or meta-analysis

A scoping review of influenza RdRp-targeting inhibitors: mechanisms, clinical translation, and emerging challenges.

Frontiers in microbiology · 2026 · PMID 42434556

BACKGROUND: Although the RNA-dependent RNA polymerase (RdRp) complex is a therapeutic target for influenza, evidence on the pharmacology, resistance, and clinical impact of RdRp-targeting inhibitors in high-risk populations remains fragmented. This scoping review on RdRp-targeting inhibitors identifies the research gaps and characterizes their mechanisms of action, pharmacokinetics, efficacy, safety, and resistance patterns. METHODS: Following the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses …

Rank94.6

Randomized controlled trial

Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study.

Nutrition research (New York, N.Y.) · 2025 · PMID 39889684

Viral infections are a global public health threat, reaffirming the importance of immune function. We previously identified Lactobacillus crispatus strain KT-11 (KT-11) and found that heat-sterilized KT-11 affect counts of T cell and dendritic cell in vitro, as well as promoted immunoglobulin A production and prevented weight loss caused by influenza virus infection in vivo. It was hypothesized that heat-sterilized KT-11 affects immune cell count/activity even in healthy individuals. We conducted a pilot study to e…

Rank85.0

Randomized clinical study

Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.

International journal of molecular sciences · 2026 · PMID 42450260

The concurrent circulation of influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unveiled complex host-pathogen interactions governed by temporal dynamics of innate immune activation. This narrative review synthesizes evidence from human air-liquid interface (ALI) epithelial models, animal studies (hamster, ferret), clinical cohorts, and randomized controlled trials (2015-2026) to delineate the molecular mechanisms underlying viral interference between these two major respi…

Rank85.0

Randomized clinical study

Tecovirimat for the treatment of monkeypox: A review of clinical trials.

Przeglad epidemiologiczny · 2026 · PMID 41979578

Monkeypox (mpox) is a disease caused by infection with the monkeypox virus, which was previously endemic in Africa and has been reported in numerous countries on other continents since 2003. Clinically, patients initially present with lymphadenopathy and flu-like prodromal symptoms, followed by a generalized rash. Mpox infection is also associated with several health complications, including pneumonia, sepsis, encephalitis, and ocular damage. Treatment is primarily symptomatic and involves relieving pain and fever,…

Rank60.0

Observational or cohort study

Opportunities and challenges of modern mobile housing systems for laying hen welfare - an observational study.

Poultry science · 2026 · PMID 42134136

A variety of commercial mobile houses for laying hens are emerging as innovative housing systems. However, only limited research on their potential for animal welfare is currently available. In this study, we compared welfare outcomes between different categories of mobile houses and with stationary systems, and aimed to identify welfare-relevant challenges associated with managing the mobile housing systems. Over a period of two years, animal-based welfare indicators (MTool©) were repeatedly assessed on 42 farms w…

Rank50.5

Other PubMed-indexed publication

Human vaccine responses regulated by parallel cytokine pathways.

Nature immunology · 2026 · PMID 42286357

Human vaccine responses vary widely, but the determinants remain incompletely defined. Here we analyzed 66 cytokines across four inactivated influenza vaccine (IIV) cohorts over five seasons (n = 581) and identified baseline serum interleukin (IL)-18 and interferon (IFN)-β as correlates of day 28 antibody responses. To test causality, we evaluated 19 cytokines in human tonsil and spleen organoids and found that type I IFNs, IL-21 and IL-12, but not IL-18 or IFNγ, enhanced antibody production. The addition of IFNβ t…

Rank49.4

Other PubMed-indexed publication

Comparative immunogenicity and cross-protection of wild-type and reverse genetics H5N8 (clade 2.3.4.4b) oil-adjuvanted vaccines against circulating H5N1 avian influenza viruses from clades 2.3.4.4b and 2.2.1.2.

Avian pathology : journal of the W.V.P.A · 2026 · PMID 42231810

Highly pathogenic avian influenza (HPAI) H5N8 viruses of clade 2.3.4.4b continue to cause devastating outbreaks worldwide, necessitating effective vaccination strategies. The comparative efficacy of wild-type versus reverse genetics (RG)-based vaccine platforms against emerging H5Nx variants remains poorly characterized, particularly regarding cross-protective immunity mechanisms. We conducted a comprehensive comparative analysis of wild-type and RG-based H5N8 (clade 2.3.4.4b) oil-adjuvanted vaccines in specific-pa…

Rank48.4

Other PubMed-indexed publication

Determining the Environmental and Ecological Factors Associated With Poultry Farm Spillover of Highly Pathogenic Avian Influenza (H5N1) in British Columbia, Canada.

Zoonoses and public health · 2026 · PMID 42136541

INTRODUCTION: Highly pathogenic avian influenza (HPAI) H5N1, clade 2.3.4.4b is a global threat causing widespread outbreaks on poultry farms and high mortality among wild bird populations in Canada. Wild aquatic birds are generally recognised as key reservoir hosts for avian influenza viruses (AIV's). Furthermore, environmental weather variables have been hypothesised to play a critical role in the spread and persistence of HPAI in the external environment. During the 2022 outbreak of HPAI (H5N1) in Canada, many po…

Rank47.3

Other PubMed-indexed publication

Genetic Characterization of Swine Influenza Viruses in Thailand in 2019-2025 Reveals Novel Reassortants.

Transboundary and emerging diseases · 2026 · PMID 42253333

Swine influenza viruses (swIAVs) pose a significant zoonotic threat. Ongoing surveillance of swIAVs in Thailand is essential due to intensive pig farming, which promotes interspecies transmission and the emergence of novel or virulent viruses. This study aimed to conduct a multiyear survey to determine the prevalence and genetically characterize the swIAVs circulating in Thai pig populations from 2019 to 2025. A total of 1629 nasal swab samples from 21 pig farms across 11 provinces in Thailand were collected and te…

Rank47.0

Other PubMed-indexed publication

Conflicts hinder research into animal movements.

Ambio · 2026 · PMID 41974979

Satellite tracking has revolutionized our understanding of animal migration, yet its reliability increasingly depends on the geopolitical stability of the regions frequented by wildlife. Here, we show that military-induced interference with global navigation satellite systems (GNSS) during ongoing conflicts in Eastern Europe has severely compromised the accuracy of global positioning systems (GPS)-based tracking data for black-headed gulls (Chroicocephalus ridibundus). In 2024-2025, GPS trajectories revealed errati…

Rank47.0

Other PubMed-indexed publication

Public-private partnership framework for highly pathogenic avian influenza surveillance: A Korean model.

Preventive veterinary medicine · 2026 · PMID 42250332

This study provides the first comprehensive PPP model for livestock disease surveillance in Korea. Highly pathogenic avian influenza (HPAI) outbreaks have increased globally, placing growing pressure on veterinary services. In the Republic of Korea, the proportion of unfilled public veterinary positions rose from 29.5% in 2019-41.4% in 2023. This study proposes a public-private partnership (PPP) framework for HPAI surveillance using the World Organisation for Animal Health (WOAH) PPP framework. We analyzed internat…

Rank47.0

Other PubMed-indexed publication

Green and applicable chromatographic approaches for the estimation of a multi-component cold and flu relief formulation along with in-vitro dissolution profiling.

Scientific reports · 2026 · PMID 42270807

The emergence of novel pharmaceutical formulations requires the establishment of a reliable analytical method that can accurately quantify active ingredients for use in diverse quality control applications. An over-the-counter pharmaceutical combination of phenylephrine hydrochloride (PHE), chlorpheniramine maleate (CPM), and ibuprofen (IBU) is formulated to treat allergy, lessen fever, and relieve congestion. Two efficient and applicable liquid chromatographic methodologies were established, with an emphasis on ec…

Rank45.0

Other PubMed-indexed publication

Lung-resident T-cell immunity dominates protection induced by an intranasal adenoviral nucleoprotein influenza vaccine.

Vaccine · 2026 · PMID 42492242

Frequent antigenic drift in influenza viruses necessitates broadly protective vaccines. This study evaluated an intranasal adenoviral-vector vaccine expressing influenza A nucleoprotein (NP) fused to the autophagy-inducing peptide C5. A heterologous prime-boost regimen using chimpanzee and bovine adenoviral platforms induced strong NP-specific humoral and cellular immune responses in mice. High serum and lung IgG/IgA level were detected, accompanied by enhanced antibody-dependent cellular cytotoxicity. Cellular ana…

Rank45.0

Other PubMed-indexed publication

Preparation of a new fluopyram-loaded nanocomposite with eco-environmental safety and its control effect on root-knot nematode disease.

Pest management science · 2026 · PMID 42265538

BACKGROUND: Metal-organic frameworks (MOFs) loaded with pesticides have unique porous structure and excellent functional properties, which can solve lower utilization rate and pesticide residues of chemical pesticides. RESULTS: ZnMOF@SiO2 loaded with Fluopyram (Flu) was prepared for the first time. The nanocomposite ZnMOF@SiO2@Flu was observed to be spherical under SEM, with a loading rate of (28.38 ± 0.77) %, and a zeta potential of -37.35 mV, and the thermal stability was 61.47% higher than that of Flu. It had pH…

Rank45.0

Other PubMed-indexed publication

The emergence of novel H3N8 and H3N3 avian influenza viruses in chickens during multi-province surveillance in China and their potential public health risk.

Veterinary journal (London, England : 1997) · 2026 · PMID 42486182

The H3 subtype avian influenza virus (AIV) poses a substantial global public health threat due to its high host adaptability and ongoing evolution. The recent emergence of novel H3N8 and H3N3 AIVs associated with cross-species transmission underscores the urgent need for enhanced epidemiological surveillance. In this study, we conducted surveillance and characterization of H3 AIVs based on a total of 737 poultry samples collected across 21 Chinese provinces from November 2022 to December 2023. Of these, 69 (9.4%) t…

Rank45.0

Other PubMed-indexed publication

Collaboration, impact, and research trends at the veterinary research institutes of the Chinese Academy of Agricultural Sciences: a bibliometric analysis from 2009 to 2023.

BMC veterinary research · 2026 · PMID 42141427

This paper examines the research output and impact of Veterinary Research Institutes (VRIs) of the Chinese Academy of Agricultural Sciences (CAAS), namely Shanghai Veterinary Research Institute (SHVRI), Harbin Veterinary Research Institute (HVRI), and Lanzhou Veterinary Research Institute (LVRI), to answer research questions. The study explores publication count, citation structure, h-index, most-cited articles, keyword trends, trend topics, co-authorship, thematic maps, and bibliographic coupling. The data is extr…

Rank45.0

Other PubMed-indexed publication

Decoding spatial transcriptomics across multicellular and subcellular resolutions.

Nature communications · 2026 · PMID 42151140

Current whole-genome spatial transcriptomics (ST) platforms, which range from multicellular (e.g., Visium) to subcellular resolution (e.g., Visium HD, Stereo-seq), face significant challenges in accurately decomposing or aggregating spots into single cells-the fundamental units of biological activity. To date, most existing computational methods operate at the spot level, and no method has effectively reconstructed transcriptomes at single-cell resolution. In this study, we present STARS (Spatial Transcriptomics ac…

Rank45.0

Other PubMed-indexed publication

A major histocompatibility complex (MHC) class II molecule that binds the same viral pathogen peptide with both nonamer and decamer core sequences for presentation to T cells.

Journal of virology · 2026 · PMID 41989306

Classical molecules encoded by the major histocompatibility complex (MHC) are central to immune responses. Compared to typical mammals, the chicken MHC is small and simple, determining life or death from economically important pathogens like avian influenza virus and Marek's disease virus (MDV). Several genes within the tightly linked chicken MHC have been suggested to determine resistance and susceptibility to MDV, but it was a surprise to find that the dominantly expressed class II molecule from the resistant B2 …

Rank45.0

Other PubMed-indexed publication

Aerosol Inhalation of a Recombinant H7N9 Hemagglutinin Antigen Elicits Systemic and Mucosal Immune Responses in Mice.

Viruses · 2026 · PMID 42198780

Highly pathogenic avian influenza A (H7N9) remains a threat to poultry health and poses a zoonotic risk, highlighting the need for vaccine antigens capable of inducing both systemic and mucosal immunity. In this study, we evaluated X33CLS-H7, a clarified cell-lysate supernatant derived from glycoengineered Pichia pastoris expressing H7 hemagglutinin, in BALB/c mice following intramuscular(i.m.) injection, nebulized inhalation, or intranasal instillation. H7 expression and hemagglutination activity were confirmed by…

Rank45.0

Other PubMed-indexed publication

Molecular Characterization of H5N1 Clade 2.3.4.4b Virus in Vaccinated Layer Chickens.

Viruses · 2026 · PMID 42357600

The global emergence of the avian influenza virus (AIV) H5N1 clade 2.3.4.4b since 2016 has caused substantial losses in wild bird and poultry populations, along with heightened risks of transmission to humans and other mammals. Vaccination of poultry has been a key strategy to curb the virus's spread and mitigate its socioeconomic impact. This report describes an outbreak of high pathogenicity avian influenza virus (HPAIV) H5N1 clade 2.3.4.4b in a flock of 15,000 brown layer chickens (170 days old), all of which ha…

Rank45.0

Other PubMed-indexed publication

Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers.

Nature communications · 2026 · PMID 42177170

Highly pathogenic avian influenza A(H5N1) virus exhibits a strong tropism for the bovine mammary gland, challenging our understanding of influenza A virus host range and tissue specificity. We performed experimental studies with an influenza A(H5N1) B3.13 genotype virus in female lactating dairy cattle to define the infectious dose, routes of exposure, and factors linked to morbidity and mortality. Here, we demonstrate that intramammary inoculation with as few as 10 TCID50 establishes a robust infection and sheddin…

Rank45.0

Other PubMed-indexed publication

African swine fever virus B66L drives extracellular mitochondrial release to promote systemic inflammation in mice.

Nature communications · 2026 · PMID 42203763

Systemic inflammation is a hallmark of viral infection, but the upstream signals that initiate it remain poorly defined. Here we show that extracellular mitochondria act as inflammatory mediators during infection by vesicular stomatitis virus, influenza A virus, rabies virus, herpes simplex virus 1 and African swine fever virus (ASFV). In ASFV-infected primary porcine alveolar macrophages, the viral protein B66L promotes the capture of damaged mitochondria by autophagosomes while blocking their fusion with lysosome…

Rank45.0

Other PubMed-indexed publication

Biosecurity assessment and seroprevalence of relevant poultry diseases in Saint Kitts commercial poultry premises.

Tropical animal health and production · 2026 · PMID 42207315

Saint Kitts (St. Kitts) and Nevis is a federation of two islands located within the West Indies. St. Kitts is anecdotally known to have commercial egg production, but disease prevalence and biosecurity practices of these farms have not previously been studied. In this study, we evaluated biosecurity practices of 11 commercial farms through a biosecurity questionnaire given to the farmers and collected blood and oropharyngeal swab samples from birds at each farm to evaluate disease prevalence. All surveyed egg-layer…

Rank45.0

Other PubMed-indexed publication

Molecular Characterisation, Isolation, and Antibody Response to Influenza D Virus in Naturally Infected Cattle.

Viruses · 2026 · PMID 42357637

Influenza D virus (IDV) is a respiratory pathogen affecting the health of cattle, thereby causing economic losses. This study was conducted to detect and isolate IDV, investigate its molecular characteristics, and examine the antibody response to IDV in naturally infected cattle. Real-time RT-PCR was used to analyse 279 nasal swabs and blood sera collected from cattle on farms in the Thrace district of Türkiye, bordering the European Union, for IDV-RNA. One sample from 2020 from a small, family-owned farm (D/OK lin…

Promising Experimental Therapies104 records

Rank100.2

Randomized controlled trial

Immunogenicity and safety of MF59-adjuvanted H5N1 pandemic influenza vaccine in healthy infants and children: a phase 2 randomized, observer-blind, multicenter study.

Vaccine · 2026 · PMID 41895156

Zoonotic influenza pandemics can cause substantial morbidity and mortality, especially in children. The present study evaluated the immunogenicity and safety of six formulations of an MF59-adjuvanted H5N1 vaccine (aH5N1). In this phase 2, dose-ranging study, children aged 6 months to <9 years were stratified by age and randomized to one of six aH5N1 formulations containing 1.875, 3.75, or 7.5 μg HA combined with 0.25 mL MF59 (standard adjuvant content) or 0.125 mL MF59 (half adjuvant content). Vaccines were adminis…

Rank100.0

Systematic review or meta-analysis

Efficacy of swine Influenza A virus vaccines on transmission, viral shedding and clinical signs: Systematic review and meta-analysis.

Preventive veterinary medicine · 2026 · PMID 41946219

Rank99.6

Randomized controlled trial

International journal of molecular sciences · 2026 · PMID 42450260

Rank85.0

Randomized clinical study

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026 · PMID 41692382

OBJECTIVES: Evidence on the impact of respiratory tract infections (RTIs) on pediatric health-related quality of life (HRQL) remains limited. This study aimed to evaluate the psychometric properties of HRQL measurement instruments for children with RTIs using longitudinal assessments. METHODS: HRQL was assessed in children younger than 16 years with RTIs using proxy-reported versions of EuroQol 5-Dimension Youth version, 3-Level (EQ-5D-Y-3L), the experimental EuroQol Toddler and Infant Populations v2.0 (EQ-TIPS), a…

Rank49.8

Other PubMed-indexed publication

Preferences for Social Media Vaccination Messaging.

JAMA network open · 2026 · PMID 41848729

IMPORTANCE: Social media is a dominant source of health information, including vaccine information, but little is known about which message characteristics audiences prefer when deciding what social media content to engage with and about how to measure these preferences. OBJECTIVE: To quantify the attributes of existing social media vaccination posts that are associated with the preference for and confidence in vaccination-related content. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used a combina…

Prospective Cohort Studies81 records

Rank99.8

Randomized controlled trial

Assessing the relationship between body mass index and influenza-like illness risk and symptom severity among military health system beneficiaries vaccinated against influenza: a pooled prospective cohort study from a randomized trial.

Frontiers in public health · 2026 · PMID 42534960

Rank92.0

Randomized controlled trialResult signal: null

A randomized assessment of the impact of 'Those Nerdy Girls' newsletters on adult vaccination outcomes.

PloS one · 2026 · PMID 41818244

Adult vaccine-preventable infectious diseases contribute substantial burden each year, and vaccine uptake remains suboptimal. As digital health communication grows, digital newsletters may represent a scalable, low-cost tool to promote vaccination. We conducted a randomized prospective study to evaluate the impact of digital newsletters on subscribers' knowledge, attitudes, and behaviors regarding four adult vaccines: respiratory syncytial virus (RSV), influenza, shingles, and COVID-19. Between November 2023 and Ja…

Rank90.8

Randomized clinical study

The Journal of infection · 2026 · PMID 42019633

OBJECTIVES: To analyze the extent and risk factors of household influenza transmission using molecular testing and viral genomes. METHODS: In a community-based cohort in the United States during 2022-2024, participants self-collected weekly nasal swabs. Swabs were tested for influenza by RT-PCR; genomic sequencing was performed. Index cases had the first influenza detection within households. Factors associated with household transmission were evaluated using Poisson regression. RESULTS: Influenza transmission was …

Rank71.1

Prospective cohort study

Factors associated with return-to-sport outcomes following pathogen-confirmed acute respiratory infections in athletes: AWARE X study.

British journal of sports medicine · 2026 · PMID 42321006

Rank70.9

Prospective cohort studyResult signal: harm

Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network.

Human vaccines & immunotherapeutics · 2026 · PMID 42053343

Safety data on COVID-19 and influenza vaccination in immunocompromised and/or autoimmune pediatric populations remains limited. This study evaluated post-vaccination health events in this vulnerable population using active surveillance data from the Canadian National Vaccine Safety (CANVAS) Network. A prospective cohort of participants aged 6 months to 19 y, who self-identified with an autoimmune and/or immunocompromised condition, were followed across several Canadian provinces (2023-2025). Participants were vacci…

Quality Of Life61 records

Rank110.8

Systematic review or meta-analysis

Vaccines for preventing infections in adults with haematological malignancies.

The Cochrane database of systematic reviews · 2025 · PMID 40396505

Rank110.0

Clinical guideline or consensus statementResult signal: harm

SEPAR Recommendations on Vaccination for Chronic Respiratory Patients.

Archivos de bronconeumologia · 2026 · PMID 40592680

Rank107.3

Systematic review or meta-analysis

Discontinuation of disease-modifying therapy in stable multiple sclerosis: A systematic review and meta-analysis.

Multiple sclerosis and related disorders · 2025 · PMID 40614415

BACKGROUND: Disease-modifying therapies (DMTs) are used to manage multiple sclerosis (MS), particularly in individuals with relapse-onset MS, to slow disease progression, reduce inflammation and demyelination and improve quality of life. Discontinuing treatment may pose a greater relapse risk for younger individuals with active disease, whereas the safety of treatment cessation in older, stable patients remains uncertain. METHODS: We conducted a systematic review and meta-analysis of studies comparing discontinuati…

Rank106.1

Systematic review or meta-analysisResult signal: null

Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.

Stem cell research & therapy · 2026 · PMID 42035205

Rank103.1

Systematic review or meta-analysis

Evidence-Based Pathways to Healthy Aging: A Systematic Review and Meta-analysis of Lifestyle Interventions for Longevity and Well-Being.

Investigacion y educacion en enfermeria · 2025 · PMID 41289530

OBJECTIVE: To evaluate the impact of multidimensional lifestyle interventions on aging outcomes, including cognitive function, physical health, emotional well-being, and longevity. METHODS: This systematic review included 35 randomized controlled trials from 2014 through 2024 using MeSH terms such as "healthy aging," "nutrition," "physical activity," "mental health," "social connections," and "preventive healthcare." Inclusion was made based on whether studies have explored at least one lifestyle intervention among…

Rank102.8

Systematic review or meta-analysis

A systematic review of health state utility values for influenza and influenza-like illness.

Journal of medical economics · 2025 · PMID 40741673

AIMS: Health economic evaluations commonly rely on quality-adjusted life years (QALYs) to measure healthcare intervention effectiveness, calculated by assigning quality weights to the time people spend in disease-specific health states. Influenza and influenza-like illness (ILI) compromise people's health-related quality of life (HRQoL), but comprehensive overviews on influenza or ILI-associated quality weights are still scarce. This systematic literature review provides an overview of studies that estimated influe…

Rank100.0

Systematic review or meta-analysis

Raising the patient's voice in influenza research and care: a systematic review of patient-reported outcomes.

BMC infectious diseases · 2026 · PMID 41723352

Rank99.6

Randomized controlled trialResult signal: null

Pediatric Bronchiectasis Action Management Plan to Improve Clinical Outcomes: A Randomized Controlled Trial.

Chest · 2025 · PMID 40930343

BACKGROUND: Managing bronchiectasis exacerbations is a priority for patients, parents, and caregivers of children with bronchiectasis. However, evidence-based strategies among the pediatric population remain limited. RESEARCH QUESTION: Does the use of a personalized, written bronchiectasis action management plan (BAMP), compared with standard care, reduce nonscheduled physician visits among children and adolescents with chronic suppurative lung disease (CSLD)/bronchiectasis? STUDY DESIGN AND METHODS: This multicent…

Rank92.0

Randomized controlled trial

Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity.

Frontiers in immunology · 2025 · PMID 41208956

INTRODUCTION: Naturally produced melatonin acts as an antioxidant and immunomodulator, regulating sleep and vital functions. Synthetic melatonin is widely used as a sleep aid by the general population, including U.S. military personnel. Immunomodulatory effects of melatonin on vaccines and therapeutics must be studied to develop and implement effective clinical practice guidelines, which will enhance the quality of life of the public and the military readiness. Here, we evaluated exogenous melatonin mediated immune…

Rank92.0

Randomized controlled trial

Patient-reported outcomes and home-based self-swabs for influenza-like illness events - lessons learned from the 2023/2024 DANFLU-2 Homeswab PRO substudy.

Journal of patient-reported outcomes · 2025 · PMID 40844659

BACKGROUND: Self-swabs and digital patient-reported outcomes (PROs) offer innovative tools for decentralized monitoring of infectious diseases. The DANFLU-2 HomeSwab PRO substudy evaluated the feasibility of using these methods for tracking influenza-like illness (ILI) within a large-scale, pragmatic, randomized trial. METHODS: During the 2023/2024 influenza season, adults aged ≥ 65 years were recruited from the DANFLU-2 trial, which evaluates the relative effectiveness of high-dose influenza vaccine compared to st…

Rank90.8

Randomized clinical studyResult signal: harm

Aspirin to prevent cardiovascular events in patients with community-acquired pneumonia or influenza (ASCAP study): protocol for a multicentre, randomised, double-blind, placebo-controlled trial.

BMJ open · 2025 · PMID 41198196

INTRODUCTION: Cardiovascular events (CVEs), in particular acute coronary syndrome (ACS), complicate the course of a significant number of patients hospitalised for community-acquired pneumonia (CAP) or influenza. Emerging evidence suggests that this increased risk of CVEs could be mitigated by the use of acetylsalicylic acid (aspirin). The ASCAP study investigates whether the addition of aspirin to standard therapy in hospitalised patients with moderate-to-severe CAP or influenza can reduce the incidence of CVEs. M…

Rank88.3

Randomized clinical study

The Lancet. Global health · 2026 · PMID 41999717

Rank68.7

Prospective cohort study

Association Between Respiratory Viral Infection and Peripheral T Lymphocyte Subsets in Elderly Patients With Acute Exacerbation of Bronchiectasis.

The clinical respiratory journal · 2025 · PMID 41448851

BACKGROUND: Respiratory viral infections are increasingly recognized as important triggers of acute exacerbations in bronchiectasis (AEB); the virological profiles and immunological mechanisms in elderly patients remain poorly characterized. METHODS: A prospective cohort of 102 elderly bronchiectasis patients was followed for 12 months. Upon AEB occurrence, nasopharyngeal swabs were obtained for multiplex fluorescence quantitative PCR detection of eight respiratory viruses, while peripheral blood samples were analy…

Rank60.0

Observational or cohort study

Antimicrobial use for influenza-like illnesses in Nha Trang, Vietnam: a cross-sectional study.

BMJ open · 2025 · PMID 40764073

OBJECTIVES: This study aimed to investigate the characteristics and management of influenza-like illnesses (ILIs) in the outpatient and inpatient settings in Vietnam. DESIGN: A cross-sectional, observational study. SETTING AND PARTICIPANTS: We conducted a questionnaire survey of 407 individuals with ILI symptoms who presented to public community health centres and the paediatric ward of a public hospital in the city of Nha Trang, Khanh Hoa Province, Vietnam, from December 2022 to March 2023. INTERVENTIONS: Not appl…

Rank54.9

Other PubMed-indexed publication

Disparities in uptake of Shingrix® vaccine in immunosuppressed individuals in England: a population-based cohort study.

Vaccine · 2026 · PMID 41435736

BACKGROUND: Herpes zoster (shingles) impacts health and quality of life, particularly in immunosuppressed individuals. The UK Shingrix® zoster vaccination programme has been available for eligible immunosuppressed individuals since 2021. Understanding Shingrix® uptake in immunosuppressed adults is critical for equitable vaccine delivery. METHODS: We conducted a population-based cohort study using primary care records from English practices contributing to Clinical Practice Research Datalink (CPRD) Aurum (1 Septembe…

Randomized Controlled Trials93 records

Rank110.8

Systematic review or meta-analysis

Vaccines for preventing infections in adults with haematological malignancies.

The Cochrane database of systematic reviews · 2025 · PMID 40396505

Rank110.0

Systematic review or meta-analysisResult signal: null

Comparative Effectiveness of High-Dose and Standard-Dose Influenza Vaccines for Hospitalisation and Mortality in Adults Aged 65 and Older: An Updated Systematic Review and Meta-Analysis.

Reviews in medical virology · 2026 · PMID 42052799

Rank107.9

Systematic review or meta-analysis

Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.

The Cochrane database of systematic reviews · 2025 · PMID 40013540

Rank107.7

Systematic review or meta-analysis

A Systematic Review and Meta-Analysis of Immunogenicity and Safety of the Influenza Vaccine in COPD Patients, and Its Relevance with Real-World Effectiveness.

International journal of chronic obstructive pulmonary disease · 2026 · PMID 41939928

Rank106.1

Systematic review or meta-analysisResult signal: null

Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.

Stem cell research & therapy · 2026 · PMID 42035205

Rank106.0

Systematic review or meta-analysisResult signal: harm

Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Transplantation and cellular therapy · 2026 · PMID 41349636

Rank105.9

Systematic review or meta-analysis

Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis.

The lancet. Healthy longevity · 2026 · PMID 42476160

Rank105.8

Systematic review or meta-analysis

Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review.

Journal of translational medicine · 2026 · PMID 41668172

Rank104.0

Systematic review or meta-analysis

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis.

JAMA network open · 2026 · PMID 42189540

Rank101.2

Randomized controlled trialResult signal: benefit

Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults.

The New England journal of medicine · 2026 · PMID 42090792

Rank100.2

Randomized controlled trial

Immunogenicity and safety of MF59-adjuvanted H5N1 pandemic influenza vaccine in healthy infants and children: a phase 2 randomized, observer-blind, multicenter study.

Vaccine · 2026 · PMID 41895156

Rank100.0

Systematic review or meta-analysisResult signal: harm

Safety and heterogeneity of mRNA-based seasonal Influenza vaccines: A systematic review and meta-analysis of randomized controlled trials.

Annals of Saudi medicine · 2026 · PMID 42001264

Rank100.0

Systematic review or meta-analysisResult signal: mixed

Systematic review and meta-analysis of digital seasonal influenza vaccination promotion in people aged ≥50 years.

Vaccine · 2026 · PMID 42320382

Rank100.0

Systematic review or meta-analysis

Enhancing uptake of respiratory vaccinations in asthma and chronic obstructive pulmonary disease (COPD) patients: a systematic review.

Vaccine · 2026 · PMID 42000586

INTRODUCTION: Despite influenza, pneumococcal and COVID vaccines being widely recommended for patients with chronic respiratory disease, vaccination rates in this cohort remain low. The aim of this systematic review is to identify interventions which are effective in increasing respiratory vaccination rates in adults with chronic obstructive pulmonary disease (COPD) or asthma. METHODS: The inclusion and exclusion criteria for the study can be found in the PROSPERO protocol (PROSPERO registration no: CRD42025588565)…

Rank100.0

Systematic review or meta-analysis

Impact of standing orders on vaccine uptake: A systematic review.

Vaccine · 2026 · PMID 42105399

OBJECTIVE: We sought to evaluate the impact of standing orders on vaccine coverage in clinical settings. METHODS: Two reviewers independently screened and included studies that evaluated use of standing orders either alone or in combination with other interventions and collected data on vaccine coverage. We extracted effect sizes for studies that used only standing orders as an intervention and had a comparison group. RESULTS: The search yielded 56 eligible studies, 22 of which evaluated standing orders-only interv…

Rank99.8

Randomized controlled trial

Assessing the relationship between body mass index and influenza-like illness risk and symptom severity among military health system beneficiaries vaccinated against influenza: a pooled prospective cohort study from a randomized trial.

Frontiers in public health · 2026 · PMID 42534960

Rank99.6

Randomized controlled trial

[Efficacy and safety of pixavir marboxil for uncomplicated influenza in adults: a phase Ⅱ, randomized, double-blind, placebo-controlled clinical trial].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases · 2026 · PMID 42373447

Rank99.0

Randomized controlled trialResult signal: benefit

Human vaccines & immunotherapeutics · 2026 · PMID 42048601

Rank98.6

Randomized controlled trial

Immunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

Vaccine · 2026 · PMID 42531981

Rank98.3

Randomized controlled trial

Immunogenicity and safety of recombinant influenza vaccine versus standard inactivated influenza vaccine in children aged 3 to 8 years: results from a phase III randomised study.

Vaccine · 2026 · PMID 42000149

Influenza vaccines for those aged <9 years old are limited to the standard-dose inactivated influenza vaccine (IIV) and live-attenuated intranasal influenza vaccine. In this Phase III, modified double-blind, active-controlled trial, participants aged 3-8 years were randomised in a 1:1 ratio to receive the quadrivalent recombinant influenza vaccine (RIV4) or quadrivalent inactivated influenza vaccine (IIV4). The non-inferiority of immune responses was assessed using geometric mean titre ratios (GMTRs) 28 days after …

Rank98.0

Randomized controlled trial

Immunogenicity and safety of higher-dose cell-based adjuvanted quadrivalent influenza vaccines: Combined results of randomised, controlled dose-finding and dose-confirmation studies.

Vaccine · 2026 · PMID 41855648

Rank98.0

Randomized controlled trial

Immunogenicity and safety of co-administration of a recombinant shingles vaccine with an mRNA COVID-19 or adjuvanted influenza vaccine: a randomised controlled trial.

The Journal of infection · 2026 · PMID 42248304

BACKGROUND: Coverage of the recombinant herpes zoster vaccine (RZV) could be improved by coadministration with seasonal vaccines. We evaluated the immunogenicity and safety of co-administration of the first or second dose of RZV with an adjuvanted quadrivalent influenza vaccine (aQIV), or mRNA COVID-19 vaccine. METHODS: A multicentre, randomised, controlled, non-inferiority phase 4 trial with masking, across 13 sites. Healthy adults ≥50 years were randomised (1:1:2:2:2) to one of five groups. Co-primary immunogenic…

Safety And Adverse Effects315 records

Rank110.0

Systematic review or meta-analysisResult signal: null

Comparative Effectiveness of High-Dose and Standard-Dose Influenza Vaccines for Hospitalisation and Mortality in Adults Aged 65 and Older: An Updated Systematic Review and Meta-Analysis.

Reviews in medical virology · 2026 · PMID 42052799

Rank109.2

Systematic review or meta-analysis

Traditional Chinese Medicine for preventing influenza: a systematic review and meta-analysis.

Frontiers in medicine · 2026 · PMID 42110432

Rank107.7

Systematic review or meta-analysis

A Systematic Review and Meta-Analysis of Immunogenicity and Safety of the Influenza Vaccine in COPD Patients, and Its Relevance with Real-World Effectiveness.

International journal of chronic obstructive pulmonary disease · 2026 · PMID 41939928

Rank106.7

Systematic review or meta-analysisResult signal: benefit

Influenza vaccination in solid organ transplant recipients: A systematic review and network meta-analysis of randomized trials.

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026 · PMID 42403499

BACKGROUND: Annual influenza vaccination is recommended for solid organ transplant (SOT) recipients, with various strategies explored to enhance efficacy. Given the ongoing uncertainty about the benefits and potential risks of different strategies in influenza vaccination in SOT recipients, comparing the indirect comparisons of the available evidence is necessary. METHODS: We searched MEDLINE, Embase, CENTRAL, and CINAHL from inception to March 2025 to identify randomized controlled trials that compared different i…

Rank106.1

Systematic review or meta-analysisResult signal: null

Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.

Stem cell research & therapy · 2026 · PMID 42035205

Rank106.0

Systematic review or meta-analysis

Influenza and Pertussis Vaccination During Pregnancy: A Systematic Review of Vaccination Rates and Vaccination Determinants.

Vaccines · 2026 · PMID 42042801

Background: Pertussis and influenza immunization during pregnancy protects both mother and infant through transplacental transfer of antibodies. However, global vaccination coverage among pregnant women remains suboptimal. Aim: This systematic review aimed to assess influenza and pertussis vaccination coverage during pregnancy and identify determinants influencing vaccine uptake. Methods: A systematic search of MEDLINE, SCOPUS, and grey literature was conducted for studies published between 2000 and 2023. Studies r…

Rank106.0

Systematic review or meta-analysisResult signal: null

High-dose quadrivalent influenza vaccine in older adults with or without cardiovascular risk: a meta-analysis of randomized trials on 511,890 participants.

Immunity & ageing : I & A · 2026 · PMID 42106814

BACKGROUND: Older adults remain highly vulnerable to serious influenza-related complications despite routine vaccination. Whether high-dose quadrivalent influenza vaccine (HD-QIV) offers greater protection than standard-dose quadrivalent influenza vaccine (SD-QIV) against clinically important outcomes remains an important question. METHODS: We conducted a systematic review and pairwise meta-analyses of randomized controlled trials (RCTs) comparing HD-QIV with SD-QIV in adults aged 65 years or older. PubMed, Cochran…

Rank105.9

Systematic review or meta-analysis

Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis.

The lancet. Healthy longevity · 2026 · PMID 42476160

Rank105.8

Systematic review or meta-analysisResult signal: null

Efficacy and Safety of Bendamustine Versus Fludarabine and Cyclophosphamide as Lymphodepleting Regimens for CAR-T Therapy in Hematological Malignancies: A Systematic Review and Meta-Analysis.

European journal of haematology · 2026 · PMID 42063324

Rank105.2

Systematic review or meta-analysis

Metabolic Effects of Modified-Release Hydrocortisone Versus Short Acting Conventional Oral Glucocorticoids in Adrenal Insufficiency: A Systematic Review and Meta-Analysis.

Clinical endocrinology · 2026 · PMID 42050347

Rank104.6

Systematic review or meta-analysis

Efficacy and Safety of Umifenovir (Arbidol) in Children with Influenza-like Illnesses: A Systematic Review and Meta-Analysis.

Pediatric reports · 2026 · PMID 42347074

Background: Pediatric influenza-like illness (ILI) represents a major global health burden. However, international treatment guidelines lack robust evidence specific to children. Umifenovir (Arbidol) is a broad-spectrum antiviral approved for pediatric use in several countries, but clinical data are fragmented and regionally limited. Methods: A comprehensive search of PubMed, Russian (RSCI, national archives, regulatory documents), and Chinese (CNKI) databases was conducted for pediatric randomized controlled trial…

Rank101.4

Systematic review or meta-analysisResult signal: null

Efficacy and Safety of Intralesional Purified Protein Derivative Versus Vitamin D for the Treatment of Cutaneous Warts: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal of clinical medicine · 2026 · PMID 42194526

Background: Cutaneous warts, caused by HPV, are common, and conventional destructive treatments often fail to prevent recurrence. Intralesional immunotherapy offers a promising alternative. Specifically, purified protein derivative (PPD) and vitamin D have demonstrated efficacy; however, a direct comparison of their therapeutic value and safety profiles is needed. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to compare the efficacy and safety of intralesional PPD versus intr…

Rank101.2

Randomized controlled trialResult signal: benefit

Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults.

The New England journal of medicine · 2026 · PMID 42090792

Rank100.2

Randomized controlled trial

Immunogenicity and safety of MF59-adjuvanted H5N1 pandemic influenza vaccine in healthy infants and children: a phase 2 randomized, observer-blind, multicenter study.

Vaccine · 2026 · PMID 41895156

Rank100.0

Systematic review or meta-analysis

Cancer reports (Hoboken, N.J.) · 2026 · PMID 41820027

Rank100.0

Systematic review or meta-analysisResult signal: harm

Safety and heterogeneity of mRNA-based seasonal Influenza vaccines: A systematic review and meta-analysis of randomized controlled trials.

Annals of Saudi medicine · 2026 · PMID 42001264

Rank100.0

Systematic review or meta-analysis

Influenza vaccination and cardiovascular and respiratory outcomes in high-risk populations: an umbrella review of systematic reviews and meta-analyzes.

Frontiers in immunology · 2026 · PMID 42273673

BACKGROUND: Influenza infection is an important trigger of acute cardiovascular events and respiratory decompensation in vulnerable populations. Although influenza vaccination may reduce cardiopulmonary morbidity and mortality, the overall certainty and methodological reliability of the evidence remain unclear. OBJECTIVE: To synthesize and critically evaluate published systematic reviews and meta-analyses on the effectiveness and safety of influenza vaccination in populations at high risk of cardiovascular and resp…

Rank99.0

Randomized controlled trialResult signal: benefit

Comparison of safety and immunogenicity between high-dose and low-dose quadrivalent influenza vaccines in children aged 6-35 months in China: A randomized, double-blind clinical study.

Human vaccines & immunotherapeutics · 2026 · PMID 42203214

Rank98.6

Randomized controlled trial

Immunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

Vaccine · 2026 · PMID 42531981

Treatments That Failed Clinical Trials60 records

Rank102.3

Randomized controlled trialResult signal: null

Influence of the Olfatín Project on the reduction of pain related to intranasal influenza vaccination, as part of a school influenza vaccination program.

Journal of pediatric nursing · 2024 · PMID 39197260

PURPOSE: To evaluate the influence of viewing the Olfatín Project video on the assessment of school LAIV-associated pain in three and four-year-old children through the Wong Baker Faces® pain classification scale. DESIGN AND METHODS: A three-arm randomized multicenter clinical trial with a placebo control group was carried out. The main variable measured was pain, assessed through the score on the Wong Baker Faces® Pain Rating Scale. There were a total population of 4591 children three and four-year-olds (born in 2…

Rank101.5

Randomized controlled trialResult signal: null

Influenza vaccination for prevention of death and major cardiovascular events in patients with a history of stroke: A subanalysis of the VIP-ACS trial.

International journal of stroke : official journal of the International Stroke Society · 2026 · PMID 40973981

BACKGROUND: An in-hospital double-dose influenza vaccination strategy's effect on preventing major adverse cardiovascular events (MACE) in patients with previous stroke is still uncertain. This study is a prespecified analysis of the vaccine against influenza to avoid cardiovascular events after the Acute Coronary Syndrome (VIP-ACS) trial. METHODS: The VIP-ACS trial was a randomized, pragmatic, multicenter, open-label trial with blinded-adjudication endpoints. Adult patients with acute coronary syndrome (ACS) ⩽ sev…

Rank99.6

Randomized controlled trialResult signal: null

Pediatric Bronchiectasis Action Management Plan to Improve Clinical Outcomes: A Randomized Controlled Trial.

Chest · 2025 · PMID 40930343

Rank99.1

Randomized controlled trialResult signal: null

Impact of multifaceted health education on influenza vaccination health literacy in primary school students: a cluster randomized controlled trial.

BMC medicine · 2025 · PMID 40468328

BACKGROUND: Influenza remains a significant public health concern globally. We assessed the impact of multifaceted health education on influenza vaccination rates and health literacy among primary school students in China. METHODS: This cluster randomized controlled trial enrolled fourth- and fifth-grade students from 20 primary schools in Dongguan, China. Schools were randomly allocated (1:1) by a computer program to either the intervention group, receiving multifaceted health education, or the control group, rece…

Rank99.1

Randomized controlled trialResult signal: benefit

Exploration of the utility of different doses of Qingfei Dayuan granules: a multicenter, randomized, double-blind, placebo-controlled trial.

Aging · 2024 · PMID 38412322

BACKGROUND: Clinical studies have confirmed that Qingfei Dayuan (QFDY) granules are effective in the treatment of influenza and upper respiratory tract infections (URTIs) caused by pulmonary heat-toxin syndrome (PHTS). Granules of Chinese medicine formulations have become a widely used dosage form in clinical practice. With the continuous optimization of extraction technology, the advantages of Chinese medicine granules have been gradually demonstrated, but the price of Chinese medicine granules is generally higher…

Rank99.0

Randomized controlled trialResult signal: null

Immunogenicity and safety of live attenuated influenza vaccine in children aged 3-17 years in China.

Vaccine · 2025 · PMID 39729925

(1) Background: The administration of a live attenuated influenza vaccine (LAIV) has emerged as a viable option for preventing pediatric infections. The LAIV vaccine is available in China based on efficacy results. However, LAIV immunogenicity in children aged 3-17 years old in China has not yet to be studied and reported broadly. (2) Methods: This is a substudy investigating the immunogenicity and safety of the LAIV under a Phase 3, multicentre, randomized, double-blind, placebo-controlled trial. A total of 3000 p…

Rank98.3

Randomized controlled trial

JCI insight · 2025 · PMID 39786918

BACKGROUNDThe immunogenicity of current influenza vaccines needs improvement. Inactivated influenza and COVID-19 mRNA vaccines can be coadministered, but randomized controlled trial data are lacking on whether the 2 vaccines are more immunogenic if given in the same arm or opposite arms. Murine studies suggest mRNA vaccines can adjuvant influenza vaccines when coformulated and codelivered.METHODSWe randomly assigned 56 adults to receive the Afluria quadrivalent inactivated influenza and Moderna monovalent SARS-CoV-…

Research information notice

Alexandria organizes PubMed-indexed literature. PubMed inclusion does not establish accuracy, endorsement, clinical applicability, or treatment suitability. Automated extraction can contain errors or omissions. This page is not medical advice.