Cancer evidence library
Liver Cancer
PubMed-indexed evidence for primary liver cancer, especially hepatocellular carcinoma.
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Liver Cancer
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Complete Ranked PubMed Index
The retrieval-priority score orders records using publication type, recency, sample-size signals, and replication signals. It is not a recommendation or a formal risk-of-bias grade.
Current Standard Of Care61 records
Rank112.0
Clinical guideline or consensus statement
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026 · PMID 41490582
The success of living donor liver transplantation (LDLT) has bridged the growing gap between organ demand and availability in patients with liver failure or liver cancer. Safety of the living liver donor (LLD) is paramount, and astute intraoperative management plays a critical role in ensuring optimal outcomes for them. Given that intraoperative surgical and anesthesia practices vary widely across centers, the International Liver Transplantation Society (ILTS) and the International Living Donor Liver Transplantatio…
Rank110.0
Clinical guideline or consensus statement
European journal of cancer (Oxford, England : 1990) · 2026 · PMID 41905243
INTRODUCTION: This document is a summary of the French intergroup guidelines for the management of liver and peritoneal metastases developed within the « cancer of unknown primary » (CUP) syndrome, published in April 2025, and available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org).
METHODS: This collaborative work was conducted under the auspices of French medical and surgical societies involved in the management of CUP. Recommendations were graded in four categories (A, B, C and …
Rank110.0
Clinical guideline or consensus statement
Gastroenterology · 2026 · PMID 42017860
DESCRIPTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in patients with cirrhosis. Although advancements in surgical, locoregional, and systemic therapies have improved outcomes for patients with early-stage HCC, most cases are diagnosed at later stages due to both the limitations of currently recommended surveillance modalities and their underuse, with fewer than 1 in 4 patients with cirrhosis receiving surveillance for this tumor. Current guidelines recommend semiannual surveillanc…
Rank110.0
Clinical guideline or consensus statementCorrection flagged
The Lancet. Haematology · 2026 · PMID 42069412
Autosomal dominant acute porphyrias are rare inherited disorders of haem biosynthesis characterised by accumulation of potentially neurotoxic porphyrin precursors and attacks of severe abdominal pain with autonomic and neuropsychiatric features. Disease severity ranges from asymptomatic individuals to those with recurrent, life-threatening attacks. The International Porphyria Network invited 34 acute porphyria specialists from 17 countries to form an expert panel. The invited group included clinicians from diverse …
Rank110.0
Clinical guideline or consensus statement
Journal of hepatology · 2026 · PMID 42191458
Steatotic liver disease (SLD) comprises a heterogeneous group of liver diseases defined by pathological hepatic lipid accumulation with varying degrees of steatohepatitis and progressive fibrosis, which may culminate in cirrhosis and/or hepatocellular carcinoma. SLD encompasses metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called non-alcoholic fatty liver disease (NAFLD); MetALD, describing patients with MASLD consuming moderately high amounts of alcohol; and alcohol-associated/related …
Rank110.0
Clinical guideline or consensus statement
Hepatology (Baltimore, Md.) · 2026 · PMID 41405234
BACKGROUND AND AIMS: Liver transplant is a specialized treatment for a spectrum of indications that use a scarce resource. Transplant is guided by principles of justice, equity, and benefit, with a constant conflict between competing interests. Organs are a national resource with a goal of equitable distribution across sites. An AASLD guideline for the evaluation and selection of appropriate candidates for transplant has been available since 2005.
METHODS: A multidisciplinary writing group of liver transplant exper…
Rank110.0
Clinical guideline or consensus statement
Journal of gastroenterology · 2026 · PMID 42120590
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, with an increasing number of patients progressing to cirrhosis and hepatocellular carcinoma (HCC). Early identification of individuals at high risk for advanced fibrosis is essential for preventing liver-related events and improving long-term outcomes. This guideline summarizes current evidence and provides practical recommendations for the diagnosis, risk stratification, and managemen…
Rank110.0
Clinical guideline or consensus statement
Gastroenterologia y hepatologia · 2026 · PMID 42061813
The hepatitis delta virus (HDV), whose infection depends on the presence of the hepatitis B virus (HBV), is associated with one of the chronic viral hepatitis that most rapidly progresses to advanced liver disease, including liver cirrhosis and/or hepatocellular carcinoma. In this context, screening for HBV/HDV infection is key to the early diagnosis of hepatitis D, improving the prognosis of infected individuals through a strategy that has proven to be effective and efficient. This document reviews the epidemiolog…
Rank110.0
Clinical guideline or consensus statement
Hepatology (Baltimore, Md.) · 2026 · PMID 41186418
BACKGROUND AND AIMS: Accumulating data related to prevention, surveillance and treatment of chronic hepatitis B (CHB) provided the impetus for this updated guideline, using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach.
METHODS: The guideline was developed in compliance with the National Academy of Medicine standards. The guideline panel developed structured questions following the Population, Intervention Comparison, Outcomes (PICO) framework. The panel addressed 6 PICO ques…
Rank110.0
Clinical guideline or consensus statement
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 41611580
Chronic hepatitis Delta virus (HDV) infection represents the most severe form of viral hepatitis, characterized by accelerated progression to cirrhosis, end-stage liver disease, and hepatocellular carcinoma. For decades, Pegylated Interferon (PegIFNα) has been the only therapeutic option, with limited efficacy and poor tolerability. The approval of the HBV/HDV entry inhibitor Bulevirtide marked a turning point, by providing the first anti-HDV specific antiviral drug. This position paper, developed jointly by the It…
Rank109.2
Systematic review or meta-analysis
Alimentary pharmacology & therapeutics · 2026 · PMID 41882492
BACKGROUND: Cirrhosis is the irreversible architectural endpoint of chronic liver disease and is the greatest risk factor for hepatocellular carcinoma (HCC). Despite its centrality in HCC management algorithms, there are no standardised morphologic criteria for diagnosing cirrhosis on cross-sectional imaging. Criteria used in clinical studies and clinical practice guidelines have not been reviewed systematically. We aim to assess cross-sectional imaging criteria in clinical practice guidelines and clinical studies.…
Rank107.0
Systematic review or meta-analysis
Medicine · 2026 · PMID 42299577
BACKGROUND: Beyond surgical intervention, hepatocellular carcinoma is mainly treated with 3 main approaches: transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) as local treatment, immune checkpoint inhibitors (ICIs), and tyrosine kinase inhibitors (TKIs). Up to now, clinical experts have not reached a consistent consensus on how to reasonably select combination therapy. Therefore, we performed this research to contrast the clinical outcomes of local treatment plus ICIs and TKIs …
Rank103.0
Systematic review or meta-analysis
BMC gastroenterology · 2026 · PMID 42157114
BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by high mortality, frequent recurrence, and limited long-term benefit from systemic therapy and radiotherapy. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs with high molecular stability and tissue-specific expression, have emerged as important regulators of HCC biology and treatment response.
METHODS: We searched PubMed from database inception to May 2, 2026 and manually screened the reference lists of eligible studies and relevant…
Rank102.0
Systematic review or meta-analysis
Journal of robotic surgery · 2026 · PMID 41933224
Digital technologies (3D imaging, surgical navigation, AR, and robot-assisted hepatobiliary technologies) have advanced liver surgery significantly. This systematic review synthesizes 2010–2025 evidence to propose a standardized workflow integrating preoperative 3D modeling, ICG fluorescence imaging, AR navigation, and (where applicable) robot-assisted techniques. We searched PubMed, Embase, Cochrane Library, and Web of Science (Jan 2010–Jul 2025) using keywords/MeSH terms. Included studies were English-language cl…
Rank98.2
Systematic review or meta-analysis
Medicine · 2026 · PMID 42536554
BACKGROUND: This study aimed to summarize and grade the existing evidence on continuous hepatic artery infusion chemotherapy (HAIC) arterial drug administration and catheter care, providing evidence-based guidance for clinical nursing decisions.
METHODS: Using the "6S" pyramid model, We searched 10 electronic resources (UpToDate, Joanna Briggs Institute [JBI], Cochrane Library, Web of Science, Embase, PubMed, EBSCOhost Research Platform, China National Knowledge Infrastructure, Wanfang, and SinoMed) and 5 professio…
Rank91.9
Randomized clinical study
Radiology and oncology · 2026 · PMID 41686533
BACKGROUND: Histopathologic growth patterns (HGPs) of colorectal liver metastases (CRLM) have emerged as potential prognostic biomarkers, though their clinical significance remains under investigation. The objective is to evaluate the prognostic value of HGPs on recurrence-free survival (RFS) and overall survival (OS) in patients undergoing liver resection for CRLM.
PATIENTS AND METHODS: This was a retrospective analysis of the OSLO-COMET randomized controlled trial, where 280 patients underwent laparoscopic or ope…
Rank79.2
Multicenter clinical study
JAMA network open · 2026 · PMID 41842895
IMPORTANCE: Colorectal cancer liver metastases (CRLM) are a common manifestation of colorectal cancer, and clinical decision-making for these patients is complex. The timing of CRLM detection, defined as synchronous, early metachronous, or late metachronous, is hypothesized to influence survival outcomes, but the prognostic implications of these classifications remain unclear.
OBJECTIVE: To determine whether the timing of CRLM detection is associated with overall survival (OS) in patients with up-front locally trea…
Rank77.0
Multicenter clinical study
Radiology. Imaging cancer · 2026 · PMID 41718532
Purpose To evaluate the generalizability of adult-trained models for hepatoblastoma segmentation to pediatric patients and to develop two deep learning (DL) models, M P C T and M p M R I , specifically trained on pediatric contrast-enhanced CT and T2-weighted MRI scans, respectively. Materials and Methods Imaging data from the multicenter Children's Oncology Group AHEP0731 trial (NCT00980460; May 2008-July 2018) were analyzed. DL models employing the three-dimensional U-Net architecture were trained using DCT-Train…
Rank73.0
Multicenter clinical study
International journal of clinical oncology · 2026 · PMID 42062697
BACKGROUND: Trifluridine/Tipiracil (FTD/TPI) combined with bevacizumab (Bev) is a standard treatment for patients with unresectable metastatic colorectal cancer (mCRC) in later-line therapy. Despite the availability of other drugs like regorafenib and fruquintinib, there is no consensus on the optimal treatment choice or sequence for later-line therapies due to a lack of clearly defined prognostic indicators. This multicenter real-world analysis aimed to identify predictive factors related to the effectiveness of F…
Rank63.6
Observational or cohort study
Investigative radiology · 2026 · PMID 41140290
OBJECTIVES: To explore magnetic resonance imaging (MRI) and gallium-68 ( 68 Ga)-DOTATATE positron emission tomography (PET) performance in the assessment of neuroendocrine liver metastases (NELMs) on a per-lesion basis, with particular attention to the contribution of individual MRI sequences and assessment of other factors that might influence their detection.
MATERIALS AND METHODS: This observational retrospective study included patients with histologically confirmed neuroendocrine tumors who underwent both contr…
Rank52.5
Other PubMed-indexed publication
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2026 · PMID 42173286
Intrahepatic cholangiocarcinoma (iCCA) is a molecularly heterogeneous liver cancer with a poor prognosis. Improved stratification is needed to guide postoperative therapy. In this study, we applied integrative multiomics analysis to classify iCCA and identify biomarkers predictive of adjuvant treatment benefit. Using publicly available datasets (including whole exome sequencing, RNA sequencing, proteomics, and phosphoproteomics from FU-iCCA cohort and a transcriptomic cohort GSE244807), we defined 3 robust molecula…
Rank51.1
Other PubMed-indexed publication
British journal of cancer · 2026 · PMID 41992059
BACKGROUND: Liver surveillance imaging is essential for detecting early asymptomatic metastases in uveal melanoma, which predominantly involves the liver. Early detection may improve treatment opportunities, but variability in imaging protocols and a lack of consensus on surveillance duration present challenges. This study aimed to evaluate our systemic surveillance protocol, optimise pathways, and assess risk factors for metastasis.
METHODS: We retrospectively analysed patients diagnosed with uveal melanoma betwee…
Rank50.6
Other PubMed-indexed publication
AJR. American journal of roentgenology · 2026 · PMID 41562458
BACKGROUND. The LI-RADS version 2018 (v2018) diagnostic algorithm prioritizes an enhancing capsule differently from other major features. The role of an enhancing capsule in hepatocellular carcinoma (HCC) diagnosis remains uncertain, particularly for CT. OBJECTIVE. The purpose of this study was to compare the diagnostic performance of CT for diagnosis of HCC using original LI-RADS v2018 criteria for LR-5 versus modified LR-5 criteria that treat an enhancing capsule the same as other major features. METHODS. This re…
Rank50.5
Other PubMed-indexed publication
European radiology experimental · 2026 · PMID 42201507
OBJECTIVE: There is still a lack of widely applicable biomarkers for immunotherapy in hepatocellular carcinoma (HCC). We aim to identify subtypes using computed tomography (CT) imaging features of HCC and assess their value in predicting prognosis and the effectiveness of immunotherapy.
MATERIALS AND METHODS: We used unsupervised consensus clustering based on quantitative contrast-enhanced CT features to identify imaging subtypes and investigated their value in predicting prognosis and the effectiveness of immunoth…
Rank50.3
Other PubMed-indexed publicationResult signal: null
Anticancer research · 2026 · PMID 41895738
BACKGROUND/AIM: In colorectal liver metastases (CRLM), peritumoral indocyanine green (ICG) fluorescence has traditionally been attributed to cholestasis caused by compression of the surrounding liver parenchyma; however, the mechanisms underlying ICG retention remain incompletely understood. Histopathological growth patterns (HGPs) represent distinct modes of tumor-liver interaction and may therefore influence ICG fluorescence characteristics. This study aimed to investigate the relationship between ICG fluorescenc…
Diagnosis And Screening60 records
Rank105.4
Systematic review or meta-analysis
European journal of radiology · 2026 · PMID 42167003
OBJECTIVE: To evaluate the diagnostic performance of magnetic resonance imaging (MRI)-based artificial intelligence (AI) models in preoperatively predicting hepatocellular carcinoma (HCC) histological grade.
METHODS: We conducted this systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy (PRISMA-DTA) guidelines. PubMed, Embase, and Web of Science were searched from inception to 10 February 2026. Bivariate random-effe…
Rank96.0
Systematic review or meta-analysis
Clinical and translational radiation oncology · 2026 · PMID 42471954
Stereotactic body radiotherapy (SBRT) is an established locoregional treatment option for hepatocellular carcinoma (HCC). However, post-treatment imaging remains challenging because tumor response and focal liver reaction (FLR), defined as radiation-related alterations of the adjacent liver parenchyma, may both evolve gradually and mimic viable or recurrent tumor. We conducted a scoping review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PR…
Rank80.1
Phase II clinical trial
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026 · PMID 42385524
AIMS: It is controversial whether monotherapy with immunotherapeutics is effective in early-stage hepatocellular carcinoma (HCC). We evaluated immunotherapy monotherapy as an initial neoadjuvant strategy.
METHODS: This prospective, single-arm, phase II trial of an adaptive neoadjuvant strategy enrolled patients with resectable, early-stage HCC. All patients received tislelizumab monotherapy; non-responders received subsequent lenvatinib combination therapy preoperatively.
RESULTS: For the overall efficacy of all 36…
Rank78.0
Multicenter clinical studyResult signal: null
European journal of radiology · 2026 · PMID 42150387
OBJECTIVE: To develop and validate radiomics models based on gadoxetate disodium (Gd-EOB-DTPA)-enhanced MRI for preoperative prediction of proliferative small hepatocellular carcinoma (sHCC) and to evaluate their prognostic value.
METHODS: A total of 331 patients with pathologically confirmed sHCC from two institutions were retrospectively enrolled and divided into training (n = 147), internal validation (n = 63), external validation (n = 59), and exploratory validation (n = 62) cohorts. Independent predictors were…
Rank73.0
Multicenter clinical study
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42338223
PURPOSE: To fully exploit the advantages of ablation planning software, discrepancies between predicted and actual ablation zones should be minimized. This study evaluated the volumetric and geometric correspondence between manufacturer-predicted and actual ablation zones following thermal liver ablation.
METHODS: This multicenter retrospective study included Emprint microwave ablations with intraprocedural needle and post-ablation confirmation CT scans. The needle position was determined on the needle confirmation…
Rank63.3
Observational or cohort study
Annals of African medicine · 2026 · PMID 42494228
CONTEXT: Liver fibrosis is a key consequence of chronic liver diseases (CLDs), leading to cirrhosis and hepatocellular carcinoma. Early detection and accurate staging are crucial for management. Magnetic resonance elastography (MRE) offers a noninvasive modality for assessing liver stiffness.
AIMS: The aim of the study was to evaluate the extent and severity of liver fibrosis in patients with CLD using MRE and to correlate MRE findings with ultrasonography (USG) and clinical parameters.
SETTINGS AND DESIGN: An obse…
Rank56.2
Other PubMed-indexed publication
The Prostate · 2026 · PMID 42263174
BACKGROUND: Metastatic prostate cancer (mPCa) exhibits highly complex metastatic patterns. Comprehensive evaluation of distinct metastatic patterns and their integrated prognostic impact remains lacking.
METHODS: Patients with mPCa were identified from the Surveillance, Epidemiology, and End Results (SEER) database, and metastatic patterns were systematically characterized. Cancer-specific survival (CSS) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using multivariable Cox regr…
Rank51.5
Other PubMed-indexed publication
Stress (Amsterdam, Netherlands) · 2026 · PMID 41491671
Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and early adversity jointly influence cortisol regulation, particularly in low- and middle-income countries (LMICs). This study examined whether harsh parenting predicts adolescent HCC and whether this association is moderated by genetic variation. Data were drawn from 1,823 particip…
Rank50.0
Other PubMed-indexed publication
Human vaccines & immunotherapeutics · 2026 · PMID 41995675
This study aimed to systematically analyze the research status, hotspots, and trends of oncolytic virotherapy (OV) for hepatocellular carcinoma (HCC) from 2000 to mid-2025, scientifically predict future directions, facilitate clinical translation, and provide a reference for subsequent studies in this field. Based on the Web of Science Core Collection and Scopus databases, bibliometric methods were adopted combined with visualization analyses using R software (version 4.5.1), VOSviewer (version 1.6.19), and CiteSpa…
Rank49.8
Other PubMed-indexed publication
Cancer letters · 2026 · PMID 42214805
Intrahepatic metastasis (IM) is a critical predictor of poor prognosis in intrahepatic cholangiocarcinoma (iCCA), yet the tumor microenvironmental mechanisms driving this process remain poorly understood. By integrating single-cell RNA sequencing data from 15 iCCA samples with a public transcriptomic cohort of 255 patients (OEP001105), we characterized the immune and malignant epithelial landscapes associated with IM. We identified ANGPTL4-positive tumor-associated macrophages and hypoxia-associated malignant epith…
Rank49.7
Other PubMed-indexed publication
European journal of radiology · 2026 · PMID 42134117
PURPOSE: To assess the image quality, apparent diffusion coefficient (ADC) values, and lesion detection of diffusion-weighted imaging (DWI) with compressed sensing (CS) and model-based deep learning (DL) reconstruction (DL-DWI) by comparing with CS-DWI.
MATERIALS AND METHODS: We retrospectively analyzed 188 patients (103 men and 85 women; mean age, 69.6 years) who underwent liver DWI between October 2024 and January 2025. DL-DWI incorporated Adaptive-CS-Net, a model-based deep learning architecture embedded within …
Rank49.7
Other PubMed-indexed publication
Clinical imaging · 2026 · PMID 42378888
PURPOSE: Transarterial chemoembolization (TACE) is standard therapy for intermediate-stage hepatocellular carcinoma (HCC), but early non-response after the first cycle remains common and unpredictable. Existing clinical scores use limited variables and fail to capture heterogeneity influencing treatment response. This study developed reproducible machine learning (ML) models to predict early non-response after first-cycle TACE using an open-access dataset.
METHODS: We analyzed 233 patients from the publicly availab…
Rank49.5
Other PubMed-indexed publication
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2026 · PMID 42261743
BACKGROUND: Many studies have reported preoperative predictors of overall survival (OS) of patients undergoing liver resection (LR) for Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC); however, their results are inconsistent.
METHODS: We included 170 patients with BCLC stage B undergoing LR during 2011-2021.
RESULTS: Multivariate analysis showed that alpha-fetoprotein (AFP) >50 ng/ml (hazard ratio [HR] = 1.959; 95% confidence interval [CI] = 1.156-3.319; p = 0.012), undergoing major rese…
Rank49.2
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42439025
PURPOSE: To evaluate the efficacy and safety of transarterial embolization (TAE) sequential microwave ablation (MWA) for hepatic hemangioma (HH).
METHODS: This single-center retrospective study included 122 patients with 134 HHs treated from 2013 to 2024. TAE was followed by CT-guided MWA after 3-14 days. Technical efficacy was defined as ≥50% HH volume reduction at 6 months post-ablation. Hemoglobinuria within 24 h after MWA was analyzed as a safety outcome. Correlation analysis was used to avoid simultaneous incl…
Rank49.2
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42449202
OBJECTIVE: Microwave ablation (MWA) is a minimally invasive therapy for liver metastases. Image guidance, primarily ultrasound (US) and computed tomography (CT), is critical for precision, but their comparative safety profiles remain debated. This study aims to compare the incidence and severity of complications between US-guided and CT-guided MWA in patients with liver metastases.
METHODS: After propensity score matching (PSM), retrospective analysis of 120 patients (2022-2024) undergoing US-guided (n = 60) or CT-…
Rank47.0
Other PubMed-indexed publicationResult signal: benefit
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42157680
INTRODUCTION: Boiling-induced susceptibility artifacts substantially degrade Proton Resonance Frequency Shift (PRFS) thermometry during hepatic microwave ablation (MWA), leading to systematic temperature errors and biased ablation-zone prediction. Existing volumetric correction approaches assume temporally static artifacts. To address this limitation, this study introduces a dynamic, frame-wise susceptibility correction for clinical 3D thermometry.
METHODS: In 10 patients (12 hepatic lesions) undergoing MRI-guided …
Rank45.0
Other PubMed-indexed publication
Biosensors & bioelectronics · 2026 · PMID 42090814
Alpha-fetoprotein (AFP) is a key biomarker for hepatocellular carcinoma, but traditional testing methods are associated with radiation risks, high costs, and insufficient sensitivity. In this work, an S-type ZnO-polydopamine (PDA) heterojunction-based photoelectrochemical (PEC) immunoassay was fabricated through a two-step thermal method, combined with cascade enzymatic reactions for the sensitive AFP quantification. The unique S-scheme charge transfer mechanism and Zn-O-C interfacial chemical bonding were rational…
Rank45.0
Other PubMed-indexed publicationResult signal: null
European journal of radiology · 2026 · PMID 42139803
PURPOSE: This study aimed to evaluate the performance of simultaneous multi-slice diffusion weighted imaging (SMS-DWI) using breath-hold (BH), free-breathing (FB), and respiratory-triggered (RT) breathing schemes in patients with hepatocellular carcinoma (HCC), focusing on image quality and apparent diffusion coefficient (ADC) repeatability.
METHODS: This prospective study consecutively enrolled HCC patients between October 2020 and March 2023, based on specific inclusion and exclusion criteria. The patients underw…
Rank45.0
Other PubMed-indexed publication
Genes & diseases · 2026 · PMID 42181000
Infection with hepatitis B virus (HBV) remains a severe concern to public health, with roughly 292 million people worldwide suffering from the chronic form of the disease, for which there is no cure. Chronic HBV infections frequently lead to hepatocellular carcinoma (HCC), one of the world's leading causes of cancer-related deaths. Although the process of hepatocarcinogenesis is complex and not fully understood, various studies have identified numerous long non-coding RNAs (lncRNAs) as contributing to the formation…
Rank45.0
Other PubMed-indexed publication
Annals of medicine · 2026 · PMID 41454610
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remaining the predominant etiological factors. Chronic viral infection not only drives carcinogenesis but also reshapes the hepatic immune microenvironment, profoundly influencing the efficacy and safety of immunotherapy.
RECENT ADVANCES: Immune checkpoint inhibitors (ICIs) have revolutionized systemic therapy for advanced HCC, with agents targeting…
Rank45.0
Other PubMed-indexed publication
Cell cycle (Georgetown, Tex.) · 2026 · PMID 41949167
Migrasomes are a recently discovered class of organelles, typically generated at the intersections and tips of retraction fibers (RFs) in migrating cells. These monolayer vesicular structures encapsulate a variety of bioactive molecules and have been shown to participate in essential physiological processes, including intercellular communication, embryonic development, immune microenvironment modulation, and mitochondrial homeostasis. Beyond their physiological roles, accumulating evidence has revealed that migraso…
Rank45.0
Other PubMed-indexed publication
Biochemical and biophysical research communications · 2026 · PMID 42364319
Diabetes mellitus and cancer represent two major global health burdens. This paper systematically reviews and analyzes recent research advances on the relationship between diabetes and cancer risk, encompassing both epidemiological and molecular mechanism studies. Epidemiological data indicate that the association between diabetes and cancer exhibits significant organ specificity, geographic and population variability, as well as type-specific differences. Diabetes mellitus significantly increases the risk of hepat…
Rank45.0
Other PubMed-indexed publication
International immunopharmacology · 2026 · PMID 42335545
BACKGROUND: Protein tyrosine phosphatases (PTPs) are pivotal in cellular signal transduction. Recent studies have identified protein tyrosine phosphatase, non-receptor type 1 (PTPN1), as a novel immune checkpoint. However, its effects and underlying mechanisms in hepatocellular carcinoma (HCC) remain underexplored. This study aims to elucidate the impact of PTPN1 on the prognosis of HCC patients, the tumor microenvironment (TME), and the biological behavior of HCC cells, with the goal of assessing its clinical pote…
Rank45.0
Other PubMed-indexed publication
Genes & diseases · 2026 · PMID 42491058
The fibroblast growth factor (FGF) 15/19-FGF receptor (FGFR) 4 signaling pathway is a crucial endocrine regulatory pathway within the FGF family. The FGF15/19-FGFR4 signaling pathway plays multiple key roles in the liver, involving core physiological processes such as metabolic regulation, bile acid homeostasis maintenance, and hepatocyte proliferation and repair, and is also closely related to the pathogenesis of various liver diseases. At present, targeted therapeutic strategies for the FGF19-FGFR4 signaling axis…
Rank45.0
Other PubMed-indexed publication
Annals of medicine · 2026 · PMID 41849648
BACKGROUND: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved endoplasmic reticulum (ER)-resident and secreted protein highly expressed in the digestive system. Emerging evidence has highlighted its pivotal roles in liver diseases, as well as in other digestive diseases including intestinal and pancreatic disorders. This review summarizes the expression, molecular mechanisms, and pathological roles of MANF in digestive diseases and evaluates its translational potential as a t…
Evidence Syntheses66 records
Rank110.0
Clinical guideline or consensus statement
Journal of gastroenterology · 2026 · PMID 42120590
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, with an increasing number of patients progressing to cirrhosis and hepatocellular carcinoma (HCC). Early identification of individuals at high risk for advanced fibrosis is essential for preventing liver-related events and improving long-term outcomes. This guideline summarizes current evidence and provides practical recommendations for the diagnosis, risk stratification, and managemen…
Rank110.0
Clinical guideline or consensus statement
Gastroenterologia y hepatologia · 2026 · PMID 42061813
The hepatitis delta virus (HDV), whose infection depends on the presence of the hepatitis B virus (HBV), is associated with one of the chronic viral hepatitis that most rapidly progresses to advanced liver disease, including liver cirrhosis and/or hepatocellular carcinoma. In this context, screening for HBV/HDV infection is key to the early diagnosis of hepatitis D, improving the prognosis of infected individuals through a strategy that has proven to be effective and efficient. This document reviews the epidemiolog…
Rank110.0
Systematic review or meta-analysis
PloS one · 2026 · PMID 42330006
BACKGROUND: The Hepatitis B virus (HBV) is one of the major causes of viral hepatitis that may persist and lead to complications, including cirrhosis, hepatic decompensation, and liver cancer. Numerous systematic reviews and meta-analysis have been conducted on HBV infection among people in Ethiopia, showing inconsistent findings. This umbrella review aimed to assess the pooled prevalence of HBV infection and its associated factors among people in Ethiopia.
METHODS: All published and unpublished systematic review a…
Rank110.0
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42285810
BACKGROUND AND AIMS: Statins have been proposed as hepatoprotective agents in chronic liver disease (CLD); however, evidence from existing systematic reviews-including observational studies and clinical trials-is inconsistent and affected by substantial overlap. We conducted an umbrella review to synthesize the available evidence on the associations between statin use and hepatological outcomes in CLD patients, while addressing study overlap.
DESIGN: PubMed, EMBASE, and Cochrane Library were searched up to Septembe…
Rank110.0
Clinical guideline or consensus statement
Gastroenterology · 2026 · PMID 42017860
DESCRIPTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in patients with cirrhosis. Although advancements in surgical, locoregional, and systemic therapies have improved outcomes for patients with early-stage HCC, most cases are diagnosed at later stages due to both the limitations of currently recommended surveillance modalities and their underuse, with fewer than 1 in 4 patients with cirrhosis receiving surveillance for this tumor. Current guidelines recommend semiannual surveillanc…
Rank110.0
Clinical guideline or consensus statement
Journal of hepatology · 2026 · PMID 42191458
Steatotic liver disease (SLD) comprises a heterogeneous group of liver diseases defined by pathological hepatic lipid accumulation with varying degrees of steatohepatitis and progressive fibrosis, which may culminate in cirrhosis and/or hepatocellular carcinoma. SLD encompasses metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called non-alcoholic fatty liver disease (NAFLD); MetALD, describing patients with MASLD consuming moderately high amounts of alcohol; and alcohol-associated/related …
Rank109.7
Systematic review or meta-analysis
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026 · PMID 42314305
BACKGROUND: Multidisciplinary team (MDT) management is widely endorsed for complex hepatobiliary and pancreatic (HBP) malignancies. However, robust systematic evidence evaluating its survival benefits and heterogeneity across distinct anatomical sites remains limited.
METHODS: Our study systematically searched four databases from their inception through Dec 17, 2025, for studies comparing MDT versus non-MDT care in HBP malignancies. The primary outcome was overall survival or mortality risk. Secondary outcomes incl…
Rank109.4
Systematic review or meta-analysis
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 42139645
PURPOSE: External beam radiation therapy (EBRT) has gained delayed acceptance as a recommended first-line treatment modality for patients with hepatocellular carcinoma (HCC), given limited evidence that it improves overall survival (OS). We analyzed individual patient data (IPD) from an international cohort to assess OS among patients with HCC treated with EBRT.
METHODS: We performed a systematic review of publications that assessed EBRT, met prespecified technical standards for HCC, and reported OS (search date De…
Rank108.9
Systematic review or meta-analysis
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026 · PMID 41999909
BACKGROUND: The management of multiple bilobar colorectal liver metastases (BCRLMs) continues to evolve, and the optimal strategy remains controversial. This was a systematic review that analyzed the outcomes of different surgical strategies for BCRLMs.
METHODS: A systematic literature search that included MEDLINE, Embase, and the Cochrane Library was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and registered in the International Prospective Register of S…
Rank108.8
Systematic review or meta-analysisResult signal: benefit
Critical reviews in oncology/hematology · 2026 · PMID 41905568
BACKGROUND: Liver metastases have been associated with poor prognosis and potentially diminished immunotherapy benefit. Comprehensive evidence regarding whether liver involvement affects the efficacy of immune checkpoint inhibitor plus chemotherapy regimens remains incomplete.
METHODS: Following PRISMA guidelines, we systematically searched five databases through May 2025 for randomized controlled trials comparing chemoimmunotherapy versus chemotherapy alone in solid tumors, with survival data stratified by liver m…
Rank108.7
Systematic review or meta-analysis
Abdominal radiology (New York) · 2026 · PMID 41364225
OBJECTIVES: Hepatocellular adenomas (HCA) are typically resected if > 5 cm after 6 months due to historical risks of bleeding and malignant transformation. Outcomes of contemporary patients managed with surveillance are not well defined. We performed a systematic review and meta-analysis of patients with HCAs monitored for ≥ 6 months to assess rates of size stability, bleeding, and malignant transformation.
METHODS: PubMed, Web of Science, and Embase databases were searched up to August 2025 for all articles report…
Rank108.4
Systematic review or meta-analysis
European journal of gastroenterology & hepatology · 2026 · PMID 41604560
Hepatic failure is a potentially fatal complication in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). However, there is a lack of clear predictive factors for hepatic failure after TACE in HCC patients. This study aimed to identify all available data and determine the risk factors associated with hepatic failure after TACE in HCC patients. A systematic review and meta-analysis included 9 studies with a total of 1654 patients. The results showed that factors significantly …
Rank107.9
Systematic review or meta-analysisResult signal: null
Journal of neurology · 2026 · PMID 42251157
BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment with significant improvements in survival rates. With the increase in ICI use in the clinical setting, several case reports and series have described neurological adverse events associated with it. We conducted this systematic review and meta-analysis to estimate the incidence of neurological adverse events among ICI clinical trials.
METHODS: We searched PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials…
Rank107.9
Systematic review or meta-analysis
Gut and liver · 2026 · PMID 42379830
BACKGROUND/AIMS: The role of direct-acting antivirals (DAAs) in patients with hepatocellular carcinoma (HCC) remains uncertain due to conflicting data on virologic efficacy and long-term outcomes.
METHODS: This meta-analysis investigated studies reporting the sustained virologic response (SVR), recurrence, and overall survival in patients with HCC treated with DAAs.
RESULTS: Eighty-eight studies were included, comprising 8,839 patients with HCC who were treated with DAAs. The pooled SVR rate in patients with HCC wa…
Rank107.7
Systematic review or meta-analysis
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026 · PMID 41996777
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and accurate staging is crucial to avoid unnecessary surgery. MRI may improve the detection of occult liver metastases when compared with CT. The impact of adding MRI on treatment timelines and cost-effectiveness remains uncertain. This systematic review synthesises the available evidence of incorporating MRI alongside CT for pre-operative staging of pancreatic cancer.
METHODS: We systematically searched MEDLINE, Embase, Web of Science, and t…
Rank107.6
Systematic review or meta-analysisResult signal: benefit
British journal of pharmacology · 2026 · PMID 41967859
Hand-foot skin reaction (HFSR) is a common adverse effect of vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs), but its prognostic value remained disputable. In this study, we aimed to assess the association between HFSR and survival outcomes in cancer patients receiving VEGFR-TKIs. MEDLINE, Embase and the Cochrane Central Register of Controlled Trials were searched from inception to 29 June 2025. Two authors independently selected cohort studies, extracted data and appraised the r…
Rank107.5
Systematic review or meta-analysis
Surgery · 2026 · PMID 42105697
BACKGROUND: Insufficient future liver remnant volume remains a critical challenge in 2-stage hepatectomy. This meta-analysis aimed to evaluate the outcome in distinct 2-stage hepatectomies with a focus on hepatic vein occlusion combined with portal vein embolization and associating liver partition and portal vein ligation for staged hepatectomy.
METHODS: A systematic literature search was conducted in MEDLINE (PubMed) up to December 2024. Comparative and noncomparative studies were included. The primary outcome was…
Rank107.5
Systematic review or meta-analysisResult signal: harm
Critical reviews in oncology/hematology · 2026 · PMID 42069094
BACKGROUND: The therapeutic landscape of HCC has evolved, with ICI-based combinations progressively replacing TKI monotherapy as standard first-line treatment, although concerns remain regarding their safety profile.
METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ICI-based combinations with TKI monotherapy as first-line treatment for advanced HCC. MEDLINE/PubMed, Scopus and the Cochrane Library were searched through December 1, 2025. The primary endpoint…
Rank107.3
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42203603
BACKGROUND: Hepatocellular carcinoma (HCC) represents a major health burden, historically treated with tyrosine kinase inhibitors (TKIs). The advent of immune checkpoint inhibitors (ICIs) has reshaped treatments, with pivotal trials (IMbrave150 and HIMALAYA) establishing ICI-based combinations as first-line therapy. Traditional statistical metrics may not fully capture the robustness of trial outcomes. The Survival-Inferred Fragility Index (SIFI) quantifies trial stability as the minimum number of additional surviv…
Rank107.0
Systematic review or meta-analysis
PloS one · 2026 · PMID 41706717
INTRODUCTION AND OBJECTIVES: Despite both hepatic arterial infusion chemotherapy (HAIC) and sorafenib being efficacious for hepatocellular carcinoma (HCC), choosing between them for Barcelona Clinic Liver Cancer (BCLC) stages B/C patients remains controversial. This meta-analysis aims to compare their therapeutic outcomes and prognoses in such patients.
METHODS: Pubmed, EMBASE, and Web of Science databases were searched. The primary outcome of this meta-analysis is Overall Survival (OS), while secondary outcomes in…
Rank107.0
Systematic review or meta-analysis
Medicine · 2026 · PMID 42299577
BACKGROUND: Beyond surgical intervention, hepatocellular carcinoma is mainly treated with 3 main approaches: transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) as local treatment, immune checkpoint inhibitors (ICIs), and tyrosine kinase inhibitors (TKIs). Up to now, clinical experts have not reached a consistent consensus on how to reasonably select combination therapy. Therefore, we performed this research to contrast the clinical outcomes of local treatment plus ICIs and TKIs …
Rank106.7
Systematic review or meta-analysis
Cancer medicine · 2024 · PMID 38634194
BACKGROUND: Recently, increasing data have suggested that the lncRNA small nucleolar RNA host genes (SNHGs) were aberrantly expressed in hepatocellular carcinoma (HCC), but the association between the prognosis of HCC and their expression remained unclear. The purpose of this meta-analysis was to determine the prognostic significance of lncRNA SNHGs in HCC.
METHODS: We systematically searched Embase, Web of Science, PubMed, and Cochrane Library for eligible articles published up to February 2024. The prognostic sig…
Rank106.6
Systematic review or meta-analysis
Medicine · 2026 · PMID 42470041
BACKGROUND: The albumin-to-globulin ratio (AGR) has emerged as a novel inflammation-based prognostic marker in various cancers; however, a comprehensive and quantitative assessment of its prognostic role in hepatocellular carcinoma (HCC) is lacking. Therefore, we conducted this meta-analysis to assess the prognostic value of the preoperative AGR in patients with HCC.
METHODS: We systematically reviewed the literature for studies reporting the prognostic impact of AGR in patients undergoing curative hepatectomy for …
Rank106.4
Systematic review or meta-analysis
Abdominal radiology (New York) · 2026 · PMID 41706100
BACKGROUND: The LI-RADS diagnostic algorithm uses imaging features in contrast-enhanced ultrasound (CEUS) to standardize the diagnosis of hepatocellular carcinoma (HCC) in at-risk patients. However, the diagnostic performance of specific major feature combinations has not been comprehensively evaluated.
PURPOSE: To evaluate the diagnostic performance of CEUS LI-RADs version 2017 major feature combinations for (HCC) in at-risk individuals across LI-RADS categories 3-5.
MATERIALS AND METHODS: A living systematic revi…
Rank106.3
Systematic review or meta-analysisResult signal: null
Journal of clinical gastroenterology · 2026 · PMID 42090574
BACKGROUND: Esophageal variceal bleeding (EVB) is a life-threatening complication of liver cirrhosis. Carvedilol, a nonselective β-blocker with α1-blocking properties, and endoscopic variceal ligation (EVL) are both recommended for prophylaxis, but their comparative performance remains uncertain.
METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted, searching PubMed, Web of Science, and Embase to July 2025. Trials comparing carvedilol with EVL in adults with cirrhosis …
Landmark Evidence47 records
Rank108.9
Systematic review or meta-analysisResult signal: null
Hepatology international · 2024 · PMID 38965190
BACKGROUND AND AIMS: The risk of hepatocellular carcinoma (HCC) occurrence following antiviral therapy in patients with chronic hepatitis C (CHC) remains unclear. The current study aims to compare: (1) the HCC occurrence rate following sustained virological response (SVR) versus non-response (NR); (2) the HCC occurrence rate following direct-acting antiviral (DAA) therapy versus interferon (IFN)-based therapy, and (3) the HCC occurrence rate in SVR patients with or without cirrhosis.
METHODS: A search was performed…
Rank108.6
Systematic review or meta-analysis
International journal of radiation oncology, biology, physics · 2024 · PMID 37597757
This systematic review and meta-analysis reports on outcomes and hepatic toxicity rates after stereotactic body radiation therapy (SBRT) for liver-confined hepatocellular carcinoma (HCC) and presents consensus guidelines regarding appropriate patient management. Using the Preferred Reporting Items for Systemic Review and Meta-Analyses guidelines, a systematic review was performed from articles reporting outcomes at ≥5 years published before October 2022 from the Embase, MEDLINE, Cochrane, and Scopus databases with …
Rank107.7
Systematic review or meta-analysis
BMC cancer · 2024 · PMID 39160484
BACKGROUND: The selection of appropriate second-line therapy for liver cancer after first-line treatment failure poses a significant clinical challenge due to the lack of direct comparative studies and standard treatment protocols. A network meta-analysis (NMA) provides a robust method to systematically evaluate the clinical outcomes and adverse effects of various second-line treatments for hepatocellular carcinoma (HCC).
METHODS: We systematically searched PubMed, Embase, Web of Science and the Cochrane Library to…
Rank107.6
Systematic review or meta-analysis
Digestive diseases and sciences · 2024 · PMID 38867097
BACKGROUND: Hepatic complications are increasingly recognized after the Fontan operation. The development of hepatocellular carcinoma (HCC) is associated with high mortality when diagnosed, but its incidence and risk factors are poorly understood. We conducted a systematic review and meta-analysis of the cumulative incidence of HCC after Fontan and associated risk factors.
METHODS: We searched PubMed, CINAHL, and MEDLINE databases for articles reporting the cumulative incidence of HCC after Fontan operation on Marc…
Rank107.5
Systematic review or meta-analysis
Current oncology (Toronto, Ont.) · 2024 · PMID 39590162
Background: Hepatocellular carcinoma (HCC) is a prevalent liver cancer with poor prognosis, often linked to hepatitis B (HBV) and C (HCV) infections. This meta-analysis evaluates the efficacy of immunotherapy in HCC, particularly in cases arising from viral hepatitis. Methods: In adherence to PRISMA Statement 2020 guidelines, the immunotherapeutic outcomes comprised objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Data were analyzed from randomized controlled trials up to A…
Rank107.0
Systematic review or meta-analysis
Metabolism: clinical and experimental · 2021 · PMID 33891949
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death worldwide. Effects of second-line oral antidiabetic medications on incident HCC risk in individuals with type 2 diabetes mellitus remain unclear. This study evaluated associations between sulfonylureas, thiazolidinediones, meglitinides and alpha-glucosidase inhibitors, and incident HCC risk.
METHODS: We systematically reviewed all studies on PubMed, Embase and Web of Science databases. Studies were included if they doc…
Rank107.0
Systematic review or meta-analysis
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023 · PMID 35940513
BACKGROUND & AIMS: Alcohol is one of the leading causes of hepatocellular carcinoma (HCC). However, pooled estimates of HCC incidence in alcohol-associated cirrhosis have not been evaluated systematically. We performed a pooled analysis of time-to-event data to provide robust estimates for the incidence of HCC in alcohol-associated cirrhosis.
METHODS: Medline, Embase, Cochrane Central Register, Scopus, and Web of Science were searched from inception to August 2021. Individual patient data were reconstructed from pu…
Rank107.0
Systematic review or meta-analysis
Journal of hepatology · 2022 · PMID 35139400
BACKGROUND & AIMS: There is controversy regarding the overall value of hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis given the lack of data from randomized-controlled trials. To address this issue, we conducted a systematic review and meta-analysis of cohort studies evaluating the benefits and harms of HCC surveillance in patients with cirrhosis.
METHODS: We performed a search of the Medline and EMBASE databases and national meeting abstracts from January 2014 through July 2020 for studies …
Rank107.0
Systematic review or meta-analysis
Digestive diseases and sciences · 2023 · PMID 35767138
BACKGROUND & AIMS: Physical activity offers promise to protect against multiple non-hepatic primary cancers. We performed a systematic review to quantify the association between physical activity and hepatocellular carcinoma (HCC) risk.
METHODS: We searched the Cochrane Library, Embase, Medline and trial registries through December 2020 for studies that measured physical activity levels in adults at risk for HCC. The primary outcome was HCC. Subgroup analysis was performed limiting to vigorous physical activity. Pr…
Rank106.5
Systematic review or meta-analysis
Frontiers in public health · 2022 · PMID 35252078
BACKGROUND: The association between environmental and socioeconomic risk factors and the occurrence of hepatocellular carcinoma (HCC) are still inconclusive. A meta-analysis was conducted to address this issue.
METHODS: We systematically searched the databases including PubMed, Web of Science, and Google Scholar and collected the related risk factors of HCC before March 6, 2020. Statistical analysis was performed on the odds ratio (OR) value and 95% CI of the correlation between environmental and socioeconomic fact…
Rank106.3
Systematic review or meta-analysis
Frontiers in immunology · 2024 · PMID 38887293
BACKGROUND: Multiple investigations and scholarly articles have presented compelling evidence indicating that tertiary lymphoid structures (TLS) play a pivotal role in inhibiting and controlling the advancement of tumors. While there is an abundance of information highlighting the importance of TLS in different cancer types, their prognostic significance specifically in hepatocellular carcinoma (HCC) cancers remains unclear. Thus, this meta-analysis aimed to explore the prognostic relevance of TLS in HCC.
METHODS: …
Rank105.7
Systematic review or meta-analysis
Gastroenterology · 2021 · PMID 34126063
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a rapidly changing landscape of treatments. In the past 20 years, numerous randomized controlled trials (RCTs) have aimed at improving outcomes across disease stages. We aimed to analyze the current evidence and identify potential factors influencing response to therapies.
METHODS: We conducted a systematic review of phase III RCTs (2002-2020) across disease stages. A meta-analysis was designed to examine the rela…
Rank105.0
Systematic review or meta-analysis
Journal of gastroenterology and hepatology · 2024 · PMID 38686439
BACKGROUND AND AIM: The purpose of the current study was to investigate the predictive value of hepatitis B core-related antigen (HBcrAg) on the occurrence and recurrence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).
METHODS: We searched PubMed, Embase, Scopus, and Web of Science from database inception to April 6, 2023. Pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was calculated for the occurrence and recurrence of HCC.
RESULTS: Of the 464 articles c…
Rank104.8
Systematic review or meta-analysisResult signal: mixed
Frontiers in immunology · 2024 · PMID 38440727
BACKGROUND: Neoadjuvant immunotherapy has demonstrated beneficial outcomes in various cancer types; however, standardized protocols for neoadjuvant immunotherapy in hepatocellular carcinoma (HCC) are currently lacking. This systematic review and meta-analysis aims to investigate the reliability of neoadjuvant immunotherapy's efficacy and safety in the context of HCC.
METHODS: A systematic search was conducted across PubMed (MEDLINE), EMBASE, the Web of Science, the Cochrane Library, and conference proceedings to id…
Rank104.7
Systematic review or meta-analysisResult signal: benefit
Clinical and experimental medicine · 2023 · PMID 35737170
INTRODUCTION: Preclinical data have revealed that beta-adrenergic stimulation can affect the growth and progression of different types of malignancies. Beta-adrenergic receptor blockers have been associated with improved survival in patients with many types of cancer. We performed a meta-analysis to investigate the association between beta-blocker use and hepatocellular carcinoma (HCC) prognosis.
METHODS: In this meta-analysis, a full search was conducted using PubMed, the Cochrane library and Embase to identify al…
Rank103.9
Systematic review or meta-analysis
Journal of hepatology · 2021 · PMID 33548385
BACKGROUND & AIMS: Biannual ultrasound has poor sensitivity for hepatocellular carcinoma (HCC) screening. MRI is accurate for the detection of HCC, but a complete MRI is not feasible as a screening tool. Abbreviated MRI (AMRI) is an acceptable alternative. The diagnostic performance of different AMRI protocols is not known. We performed a systematic review to determine the diagnostic accuracy of AMRI for HCC screening.
METHODS: We searched the MEDLINE and EMBASE databases for studies reporting the diagnostic accura…
Rank103.3
Systematic review or meta-analysis
Gut · 2021 · PMID 32398224
BACKGROUND: Tumour growth patterns have important implications for surveillance intervals, prognostication and treatment decisions but have not been well described for hepatocellular carcinoma (HCC). The aim of our study was to characterise HCC doubling time and identify correlates for indolent and rapid growth patterns.
METHODS: We performed a systematic literature review of Medline and EMBASE databases from inception to December 2019 and national meeting abstracts from 2010 to 2018. We identified studies reportin…
Rank103.0
Systematic review or meta-analysisResult signal: harm
Scientific reports · 2016 · PMID 27642100
Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We aimed to compare the use of different antidiabetic strategies and the incidence of HCC. PubMed, Embase.com and Cochrane Library databases were searched up to 31 October 2015 and randomized controlled trials (RCTs), cohort studies or case-control studies were included for our analyses. A total of thirteen studies enrolling 481358 participants with 240678 HCC cases who received at least two different strategies were retrieved in th…
Rank103.0
Systematic review or meta-analysis
BMC medicine · 2024 · PMID 39736748
BACKGROUND: Risk prediction models can identify individuals at high risk of chronic liver disease (CLD), but there is limited evidence on the performance of various models in diverse populations. We aimed to systematically review CLD prediction models, meta-analyze their performance, and externally validate them in 0.5 million Chinese adults in the China Kadoorie Biobank (CKB).
METHODS: Models were identified through a systematic review and categorized by the target population and outcomes (hepatocellular carcinoma…
Rank102.9
Systematic review or meta-analysisResult signal: benefit
Oncotarget · 2016 · PMID 26943041
OBJECTIVES: Usage of statins is suggested to decrease the incidence of HCC. When it comes to different statin subtypes, the chemopreventive action remains controversial. We aim to compare the usage of different statins and reduction of HCC risk.
METHODS: We searched PubMed, Embase.com and Cochrane Library database up to August 10, 2015. Duplicated or overlapping reports were eliminated. We performed a traditional pair-wise meta-analysis and a Bayesian network meta-analysis to compare different treatments with a ran…
Rank102.9
Systematic review or meta-analysis
Academic radiology · 2024 · PMID 38413315
BACKGROUND: Given the limited sensitivity of ultrasound in hepatocellular carcinoma (HCC) surveillance, this systematic review and meta-analysis were aimed to assess the diagnostic performance of non-contrast abbreviated MRI (NC-aMRI) compared to contrast-enhanced abbreviated MRI (CE-aMRI) for HCC surveillance, offering evidence-based guidance for clinical decision-making.
METHODS: A comprehensive search was conducted across five databases, identifying studies on aMRI for HCC surveillance. The pooled sensitivity an…
Rank102.9
Systematic review or meta-analysis
Expert review of gastroenterology & hepatology · 2018 · PMID 30004289
BACKGROUND: ABO blood type is an invariant factor. There is a link between ABO blood type and some malignancies, such as gastric, pancreatic, and skin cancer. The role of ABO blood type in the pathogenesis of hepatocellular carcinoma (HCC) remains controversial. We performed a meta-analysis to explore the relationship between ABO blood type and risk of HCC.
METHODS: Literature search was conducted among the PubMed, EMBASE, and Cochrane Library databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were cal…
Rank102.9
Systematic review or meta-analysis
United European gastroenterology journal · 2023 · PMID 37736854
BACKGROUND/AIMS: Transjugular intrahepatic portosystemic shunts (TIPS) in patients with hepatocellular carcinoma (HCC) may improve access to curative therapies, treat portal hypertension (PH)-related complications without worsening liver function, and increase overall survival. Data on the efficacy and safety of TIPS to treat PH complications in HCC patients, as well as the HCC treatment response, were evaluated.
METHODS: Studies reporting efficacy in controlling bleeding/ascites or response to HCC therapy, safety,…
Rank102.8
Systematic review or meta-analysis
PloS one · 2022 · PMID 36584078
BACKGROUND: To evaluate the clinical value of Aldo-keto reductase family 1 member B10 (AKR1B10) in the diagnosis and prognosis of hepatocellular carcinoma (HCC).
METHODS: A search of the PubMed, China Biology Medicine, Cochrane, and Embase databases was performed to conduct meta-analyses to evaluate the accuracy of AKR1B10 in diagnosing HCC and to assess the impact on prognosis of patients after curative resection of HCC.
RESULTS: A total of 12 different cohorts from 11 studies including 2747 HCC patients and 2053 …
Rank102.0
Systematic review or meta-analysis
Clinical and molecular hepatology · 2024 · PMID 38623613
BACKGROUND/AIMS: The global proportion of hepatocellular carcinoma (HCC) attributable to metabolic dysfunction-associated fatty liver disease (MAFLD) is unclear. The MAFLD diagnostic criteria allows objective diagnosis in the presence of steatosis plus defined markers of metabolic dysfunction, irrespective of concurrent liver disease. We aimed to determine the total global prevalence of MAFLD in HCC cohorts (total-MAFLD), including the proportion with MAFLD as their sole liver disease (single-MAFLD), and the propor…
Most Effective Evidence Supported Treatments68 records
Rank110.0
Clinical guideline or consensus statement
Journal of hepatology · 2026 · PMID 42191458
Steatotic liver disease (SLD) comprises a heterogeneous group of liver diseases defined by pathological hepatic lipid accumulation with varying degrees of steatohepatitis and progressive fibrosis, which may culminate in cirrhosis and/or hepatocellular carcinoma. SLD encompasses metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called non-alcoholic fatty liver disease (NAFLD); MetALD, describing patients with MASLD consuming moderately high amounts of alcohol; and alcohol-associated/related …
Rank110.0
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42285810
BACKGROUND AND AIMS: Statins have been proposed as hepatoprotective agents in chronic liver disease (CLD); however, evidence from existing systematic reviews-including observational studies and clinical trials-is inconsistent and affected by substantial overlap. We conducted an umbrella review to synthesize the available evidence on the associations between statin use and hepatological outcomes in CLD patients, while addressing study overlap.
DESIGN: PubMed, EMBASE, and Cochrane Library were searched up to Septembe…
Rank109.7
Systematic review or meta-analysis
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026 · PMID 42314305
BACKGROUND: Multidisciplinary team (MDT) management is widely endorsed for complex hepatobiliary and pancreatic (HBP) malignancies. However, robust systematic evidence evaluating its survival benefits and heterogeneity across distinct anatomical sites remains limited.
METHODS: Our study systematically searched four databases from their inception through Dec 17, 2025, for studies comparing MDT versus non-MDT care in HBP malignancies. The primary outcome was overall survival or mortality risk. Secondary outcomes incl…
Rank109.4
Systematic review or meta-analysis
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 42139645
PURPOSE: External beam radiation therapy (EBRT) has gained delayed acceptance as a recommended first-line treatment modality for patients with hepatocellular carcinoma (HCC), given limited evidence that it improves overall survival (OS). We analyzed individual patient data (IPD) from an international cohort to assess OS among patients with HCC treated with EBRT.
METHODS: We performed a systematic review of publications that assessed EBRT, met prespecified technical standards for HCC, and reported OS (search date De…
Rank108.9
Systematic review or meta-analysis
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026 · PMID 41999909
BACKGROUND: The management of multiple bilobar colorectal liver metastases (BCRLMs) continues to evolve, and the optimal strategy remains controversial. This was a systematic review that analyzed the outcomes of different surgical strategies for BCRLMs.
METHODS: A systematic literature search that included MEDLINE, Embase, and the Cochrane Library was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and registered in the International Prospective Register of S…
Rank108.8
Systematic review or meta-analysisResult signal: benefit
Critical reviews in oncology/hematology · 2026 · PMID 41905568
BACKGROUND: Liver metastases have been associated with poor prognosis and potentially diminished immunotherapy benefit. Comprehensive evidence regarding whether liver involvement affects the efficacy of immune checkpoint inhibitor plus chemotherapy regimens remains incomplete.
METHODS: Following PRISMA guidelines, we systematically searched five databases through May 2025 for randomized controlled trials comparing chemoimmunotherapy versus chemotherapy alone in solid tumors, with survival data stratified by liver m…
Rank108.4
Systematic review or meta-analysis
European journal of gastroenterology & hepatology · 2026 · PMID 41604560
Hepatic failure is a potentially fatal complication in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). However, there is a lack of clear predictive factors for hepatic failure after TACE in HCC patients. This study aimed to identify all available data and determine the risk factors associated with hepatic failure after TACE in HCC patients. A systematic review and meta-analysis included 9 studies with a total of 1654 patients. The results showed that factors significantly …
Rank107.9
Systematic review or meta-analysis
Gut and liver · 2026 · PMID 42379830
BACKGROUND/AIMS: The role of direct-acting antivirals (DAAs) in patients with hepatocellular carcinoma (HCC) remains uncertain due to conflicting data on virologic efficacy and long-term outcomes.
METHODS: This meta-analysis investigated studies reporting the sustained virologic response (SVR), recurrence, and overall survival in patients with HCC treated with DAAs.
RESULTS: Eighty-eight studies were included, comprising 8,839 patients with HCC who were treated with DAAs. The pooled SVR rate in patients with HCC wa…
Rank107.9
Systematic review or meta-analysisResult signal: null
Journal of neurology · 2026 · PMID 42251157
BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment with significant improvements in survival rates. With the increase in ICI use in the clinical setting, several case reports and series have described neurological adverse events associated with it. We conducted this systematic review and meta-analysis to estimate the incidence of neurological adverse events among ICI clinical trials.
METHODS: We searched PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials…
Rank107.6
Systematic review or meta-analysisResult signal: benefit
British journal of pharmacology · 2026 · PMID 41967859
Hand-foot skin reaction (HFSR) is a common adverse effect of vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs), but its prognostic value remained disputable. In this study, we aimed to assess the association between HFSR and survival outcomes in cancer patients receiving VEGFR-TKIs. MEDLINE, Embase and the Cochrane Central Register of Controlled Trials were searched from inception to 29 June 2025. Two authors independently selected cohort studies, extracted data and appraised the r…
Rank107.5
Systematic review or meta-analysis
Surgery · 2026 · PMID 42105697
BACKGROUND: Insufficient future liver remnant volume remains a critical challenge in 2-stage hepatectomy. This meta-analysis aimed to evaluate the outcome in distinct 2-stage hepatectomies with a focus on hepatic vein occlusion combined with portal vein embolization and associating liver partition and portal vein ligation for staged hepatectomy.
METHODS: A systematic literature search was conducted in MEDLINE (PubMed) up to December 2024. Comparative and noncomparative studies were included. The primary outcome was…
Rank107.5
Systematic review or meta-analysisResult signal: harm
Critical reviews in oncology/hematology · 2026 · PMID 42069094
BACKGROUND: The therapeutic landscape of HCC has evolved, with ICI-based combinations progressively replacing TKI monotherapy as standard first-line treatment, although concerns remain regarding their safety profile.
METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ICI-based combinations with TKI monotherapy as first-line treatment for advanced HCC. MEDLINE/PubMed, Scopus and the Cochrane Library were searched through December 1, 2025. The primary endpoint…
Rank107.3
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42203603
BACKGROUND: Hepatocellular carcinoma (HCC) represents a major health burden, historically treated with tyrosine kinase inhibitors (TKIs). The advent of immune checkpoint inhibitors (ICIs) has reshaped treatments, with pivotal trials (IMbrave150 and HIMALAYA) establishing ICI-based combinations as first-line therapy. Traditional statistical metrics may not fully capture the robustness of trial outcomes. The Survival-Inferred Fragility Index (SIFI) quantifies trial stability as the minimum number of additional surviv…
Rank107.0
Systematic review or meta-analysis
PloS one · 2026 · PMID 41706717
INTRODUCTION AND OBJECTIVES: Despite both hepatic arterial infusion chemotherapy (HAIC) and sorafenib being efficacious for hepatocellular carcinoma (HCC), choosing between them for Barcelona Clinic Liver Cancer (BCLC) stages B/C patients remains controversial. This meta-analysis aims to compare their therapeutic outcomes and prognoses in such patients.
METHODS: Pubmed, EMBASE, and Web of Science databases were searched. The primary outcome of this meta-analysis is Overall Survival (OS), while secondary outcomes in…
Rank107.0
Systematic review or meta-analysis
Medicine · 2026 · PMID 42299577
BACKGROUND: Beyond surgical intervention, hepatocellular carcinoma is mainly treated with 3 main approaches: transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) as local treatment, immune checkpoint inhibitors (ICIs), and tyrosine kinase inhibitors (TKIs). Up to now, clinical experts have not reached a consistent consensus on how to reasonably select combination therapy. Therefore, we performed this research to contrast the clinical outcomes of local treatment plus ICIs and TKIs …
Rank106.6
Systematic review or meta-analysis
Medicine · 2026 · PMID 42470041
BACKGROUND: The albumin-to-globulin ratio (AGR) has emerged as a novel inflammation-based prognostic marker in various cancers; however, a comprehensive and quantitative assessment of its prognostic role in hepatocellular carcinoma (HCC) is lacking. Therefore, we conducted this meta-analysis to assess the prognostic value of the preoperative AGR in patients with HCC.
METHODS: We systematically reviewed the literature for studies reporting the prognostic impact of AGR in patients undergoing curative hepatectomy for …
Rank106.3
Systematic review or meta-analysisResult signal: null
Journal of clinical gastroenterology · 2026 · PMID 42090574
BACKGROUND: Esophageal variceal bleeding (EVB) is a life-threatening complication of liver cirrhosis. Carvedilol, a nonselective β-blocker with α1-blocking properties, and endoscopic variceal ligation (EVL) are both recommended for prophylaxis, but their comparative performance remains uncertain.
METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted, searching PubMed, Web of Science, and Embase to July 2025. Trials comparing carvedilol with EVL in adults with cirrhosis …
Rank106.0
Systematic review or meta-analysis
Diabetes care · 2026 · PMID 41973508
BACKGROUND: Type 2 diabetes mellitus (T2DM) amplifies liver disease burden, yet the comparative hepatic effects of glucose-lowering drugs remain poorly defined.
PURPOSE: To compare associations between glucose-lowering drug classes and major adverse liver outcomes (MALOs) in adults with T2DM.
DATA SOURCES: PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched from December 1946 through 23 August 2025.
STUDY SELECTION: Studies enrolling adults with T2DM that evaluated associations between …
Rank105.9
Systematic review or meta-analysisResult signal: harm
Journal of gastrointestinal cancer · 2026 · PMID 42461487
PURPOSE: The incidence of LNM and survival outcomes following routine lymph node dissection (LND) in patients undergoing resection of hepatocellular carcinoma (HCC), intrahepatic- (ICC) and perihilar cholangiocarcinoma (PCC) has not been well-defined. This systematic review and meta-analysis analyzes the incidence of LNM and survival outcomes following routine LND independently of pre-or intraoperative suspicion of LNM following resection of HCC, ICC, and PCC.
METHODS: The PubMed database was searched from database…
Rank105.8
Systematic review or meta-analysis
Frontiers in immunology · 2026 · PMID 42327777
BACKGROUND: The therapeutic landscape of advanced hepatocellular carcinoma (HCC) has expanded beyond sorafenib, with multiple combination regimens now demonstrating improved outcomes. However, the absence of direct head-to-head comparisons complicates treatment selection in clinical practice.
METHODS: We performed a Bayesian network meta-analysis of phase III randomized controlled trials to compare the efficacy and safety of first-line treatments for patients with advanced HCC. Overall survival (OS), progression-fr…
Rank105.8
Systematic review or meta-analysis
Cancer research and treatment · 2026 · PMID 40808533
PURPOSE: Lymph node metastasis (LNM) of hepatocellular carcinoma (HCC) carries a poor prognosis; however, no standard treatment has been established. Radiotherapy (RT) has demonstrated favorable tumor response, with the advantage of being less affected by anatomical hindrances.
MATERIALS AND METHODS: Databases were searched up to April 2024. The inclusion criteria were ≥ 5 patients with HCC LNM, studies that performed external RT, and reporting survival or response rate (RR). The main effect measures are pooled 1- …
Rank105.5
Systematic review or meta-analysisResult signal: benefit
Surgery · 2026 · PMID 42373423
BACKGROUND: Increasingly, published evidence is documenting survival advantages of resecting cancerous lesions in the liver, whether primary or metastatic. However, an average of 15% of such lesions are missed, especially when multiple lesions exist, since intraoperative ultrasound, the gold-standard intraoperative imaging technique, often misses lesions near the hepatic surface. In this meta-analysis, we examined whether adding fluorescence imaging with indocyanine green to intraoperative ultrasound increases the …
Rank105.4
Systematic review or meta-analysis
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026 · PMID 41490475
Bridging and downstaging are indications for locoregional therapy (LRT) in hepatocellular carcinoma (HCC) within the context of liver transplantation (LT). Stereotactic body radiation therapy (SBRT) is an emerging LRT modality in these settings. We conducted a systematic review and meta-analysis to assess the efficacy and safety of SBRT as bridging or downstaging therapy. A comprehensive search of PubMed, Embase, and Cochrane Library was performed through July 21, 2025. We included randomized and non-randomized stu…
Rank104.8
Systematic review or meta-analysis
Hepatobiliary & pancreatic diseases international : HBPD INT · 2026 · PMID 42177126
BACKGROUND: Neuroendocrine liver metastases (NLMs) from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) significantly impact morbidity and mortality. While surgical resection remains the standard treatment, radiofrequency ablation (RFA) has emerged as an alternative for unresectable cases. This systematic review compared the oncological outcomes of surgical resection and RFA.
DATA SOURCES: A systematic search of PubMed, Web of Science, and Scopus identified studies published between 2014 and 2025. Eligible …
Rank104.6
Systematic review or meta-analysis
Journal of pediatric surgery · 2026 · PMID 41833711
INTRODUCTION: Despite the broader adoption of minimally invasive liver surgery (MILS) for adults, its application in the pediatric population has been mainly documented in single-center reports. We aimed to summarize the current state of evidence of MILS in children.
METHODS: We systematically reviewed PubMed, Scopus, Web of Science, and Cochrane Library databases according to the PRISMA statement for children (<18 years) undergoing MILS (end-of-search date: 03/03/2024). The National Cancer Database (NCDB) was quer…
New Research Last 24 Months60 records
Rank73.0
Multicenter clinical study
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42338223
PURPOSE: To fully exploit the advantages of ablation planning software, discrepancies between predicted and actual ablation zones should be minimized. This study evaluated the volumetric and geometric correspondence between manufacturer-predicted and actual ablation zones following thermal liver ablation.
METHODS: This multicenter retrospective study included Emprint microwave ablations with intraprocedural needle and post-ablation confirmation CT scans. The needle position was determined on the needle confirmation…
Rank57.2
Other PubMed-indexed publication
Asia-Pacific journal of oncology nursing · 2026 · PMID 41858761
OBJECTIVE: To develop a clinical model for the early prediction of moderate-to-severe pain after Hepatic Artery Infusion Chemotherapy (HAIC) in liver cancer patients using XGBoost algorithm and then compare its prediction capacity with the logistic model.
METHODS: A multicenter cohort study presented according to TRIPOD + AI statement, which was conducted in 3 tertiary hospitals in Shanghai from May 2022 to June 2024. Lasso regression was used to screen for risk factors. Logistic regression and XGBoost algorithm we…
Rank51.5
Other PubMed-indexed publication
Stress (Amsterdam, Netherlands) · 2026 · PMID 41491671
Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and early adversity jointly influence cortisol regulation, particularly in low- and middle-income countries (LMICs). This study examined whether harsh parenting predicts adolescent HCC and whether this association is moderated by genetic variation. Data were drawn from 1,823 particip…
Rank51.0
Other PubMed-indexed publication
Annals of medicine · 2026 · PMID 42003514
BACKGROUND: Chronic hepatitis B (CHB) is a major cause of hepatocellular carcinoma (HCC). In patients receiving CHB treatment, coexistence of steatotic liver disease (SLD) and cardiometabolic risk factors (CMRFs) markedly influence HCC risk. This study explored hepatic and metabolic profiles, HCC predictors, and the modifying roles of SLD and CMRFs in CHB.
METHODS: This study included 1012 patients receiving nucleos(t)ide analogs between 2004 and 2022. They were stratified into SLD (N = 702) or non-SLD (N = 310) gr…
Rank50.0
Other PubMed-indexed publication
Human vaccines & immunotherapeutics · 2026 · PMID 41995675
This study aimed to systematically analyze the research status, hotspots, and trends of oncolytic virotherapy (OV) for hepatocellular carcinoma (HCC) from 2000 to mid-2025, scientifically predict future directions, facilitate clinical translation, and provide a reference for subsequent studies in this field. Based on the Web of Science Core Collection and Scopus databases, bibliometric methods were adopted combined with visualization analyses using R software (version 4.5.1), VOSviewer (version 1.6.19), and CiteSpa…
Rank49.9
Other PubMed-indexed publication
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2026 · PMID 41660702
BACKGROUND: Antiviral therapies for hepatitis B or C virus may be associated with reduced risk of tumor recurrence and mortality of patients with hepatocellular carcinoma (HCC) undergoing curative treatments, compared to untreated patients. Previous studies comparing survival outcomes between percutaneous radiofrequency ablation (RFA) and liver resection (LR) for treating patients with very early-stage HCC did not evaluate the effects of antiviral treatments on survival outcome. Our study aimed to clarify this issu…
Rank49.7
Other PubMed-indexed publication
Asia-Pacific journal of oncology nursing · 2026 · PMID 42358731
OBJECTIVE: This study aimed to investigate the dynamic temporal associations among postoperative symptoms in patients with liver cancer using a cross-lagged panel network (CLPN) model, and to identify stage-specific core symptoms to inform targeted clinical interventions.
METHODS: A longitudinal study was conducted involving 230 patients with liver cancer. Symptoms were assessed using the MD Anderson Symptom Inventory (MDASI) and the Symptom Module Specific to Primary Liver Cancer (SM-PLC) at five time points: 2 da…
Rank49.5
Other PubMed-indexed publication
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2026 · PMID 42261743
BACKGROUND: Many studies have reported preoperative predictors of overall survival (OS) of patients undergoing liver resection (LR) for Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC); however, their results are inconsistent.
METHODS: We included 170 patients with BCLC stage B undergoing LR during 2011-2021.
RESULTS: Multivariate analysis showed that alpha-fetoprotein (AFP) >50 ng/ml (hazard ratio [HR] = 1.959; 95% confidence interval [CI] = 1.156-3.319; p = 0.012), undergoing major rese…
Rank49.2
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42449202
OBJECTIVE: Microwave ablation (MWA) is a minimally invasive therapy for liver metastases. Image guidance, primarily ultrasound (US) and computed tomography (CT), is critical for precision, but their comparative safety profiles remain debated. This study aims to compare the incidence and severity of complications between US-guided and CT-guided MWA in patients with liver metastases.
METHODS: After propensity score matching (PSM), retrospective analysis of 120 patients (2022-2024) undergoing US-guided (n = 60) or CT-…
Rank49.2
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42439025
PURPOSE: To evaluate the efficacy and safety of transarterial embolization (TAE) sequential microwave ablation (MWA) for hepatic hemangioma (HH).
METHODS: This single-center retrospective study included 122 patients with 134 HHs treated from 2013 to 2024. TAE was followed by CT-guided MWA after 3-14 days. Technical efficacy was defined as ≥50% HH volume reduction at 6 months post-ablation. Hemoglobinuria within 24 h after MWA was analyzed as a safety outcome. Correlation analysis was used to avoid simultaneous incl…
Rank47.0
Other PubMed-indexed publicationResult signal: benefit
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42157680
INTRODUCTION: Boiling-induced susceptibility artifacts substantially degrade Proton Resonance Frequency Shift (PRFS) thermometry during hepatic microwave ablation (MWA), leading to systematic temperature errors and biased ablation-zone prediction. Existing volumetric correction approaches assume temporally static artifacts. To address this limitation, this study introduces a dynamic, frame-wise susceptibility correction for clinical 3D thermometry.
METHODS: In 10 patients (12 hepatic lesions) undergoing MRI-guided …
Rank45.0
Other PubMed-indexed publication
Genes & diseases · 2026 · PMID 42491058
The fibroblast growth factor (FGF) 15/19-FGF receptor (FGFR) 4 signaling pathway is a crucial endocrine regulatory pathway within the FGF family. The FGF15/19-FGFR4 signaling pathway plays multiple key roles in the liver, involving core physiological processes such as metabolic regulation, bile acid homeostasis maintenance, and hepatocyte proliferation and repair, and is also closely related to the pathogenesis of various liver diseases. At present, targeted therapeutic strategies for the FGF19-FGFR4 signaling axis…
Rank45.0
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42345510
BACKGROUND AND OBJECTIVE: Microwave ablation is a well-established therapy for liver tumors, but its efficacy is strongly influenced by blood perfusion. Most computational studies simplify perfusion as an isotropic sink, neglecting flow orientation. This work introduces the Antenna-Blood flow Relative Angle (ABRA) to quantify the effects of flow direction and velocity on ablation zone geometry using a commercial ECO Ceramic 14 G antenna.
METHODS: Ex vivo bovine liver experiments were performed under standardized co…
Rank45.0
Other PubMed-indexed publication
Cell cycle (Georgetown, Tex.) · 2026 · PMID 41949167
Migrasomes are a recently discovered class of organelles, typically generated at the intersections and tips of retraction fibers (RFs) in migrating cells. These monolayer vesicular structures encapsulate a variety of bioactive molecules and have been shown to participate in essential physiological processes, including intercellular communication, embryonic development, immune microenvironment modulation, and mitochondrial homeostasis. Beyond their physiological roles, accumulating evidence has revealed that migraso…
Rank45.0
Other PubMed-indexed publication
Biosensors & bioelectronics · 2026 · PMID 42372685
Single-mode biosensor is prone to external interference, and detection of a single biomarker is insufficient for accurate diagnosis of liver cancer. Herein, we report a 7-(Diethylamino)coumarin-3-carboxylic acid (7DCCA) functionalized aptamers induced photoelectrochemical(PEC)/fluorescence(FL) dual-mode aptasensor integrated into a three-channel microfluidic chip for multiplexed detection of three liver cancer biomarkers: alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and Golgi protein 73 (GP73). A robust…
Rank45.0
Other PubMed-indexed publication
RNA biology · 2026 · PMID 41937349
NOL1/NOP2/SUN domain family member 2 (NSUN2), a member of the RNA methyltransferase family responsible for catalysing 5-methylcytosine (m5 C) modifications, has been increasingly recognized as a key regulatory factor in the initiation and progression of cancer. A growing body of evidence indicates that NSUN2 is aberrantly expressed in multiple malignancies, such as hepatocellular carcinoma, breast cancer, and gastric cancer, where its overexpression is frequently associated with unfavourable clinical outcomes, incr…
Rank45.0
Other PubMed-indexed publication
Cell adhesion & migration · 2026 · PMID 42002886
Meox1 is aberrantly expressed in several malignancies, but its role in hepatocellular carcinoma (HCC) remains unclear. This study aimed to investigate the effects of Meox1 on HCC cells and explore the underlying molecular mechanisms. Cell proliferation, colony formation, migration, invasion, and cell cycle distribution were assessed by CCK-8, clonogenic, Transwell, and flow cytometry assays, respectively. Protein expression was examined by Western blotting. Meox1 silencing significantly inhibited proliferation, clo…
Rank45.0
Other PubMed-indexed publication
Journal of medical economics · 2026 · PMID 42033418
AIM: This study aims to evaluate the cost-effectiveness of atezolizumab plus bevacizumab as first-line systemic therapy for unresectable hepatocellular carcinoma (uHCC) in Malaysia, compared with the current standard treatments in the Malaysian Ministry of Health (MOH) to inform public healthcare decision‑making.
MATERIALS AND METHODS: A cost-effectiveness analysis was conducted from the MOH perspective, following the national pharmacoeconomic guidelines (2019). The study compared atezolizumab plus bevacizumab with…
Rank45.0
Other PubMed-indexed publication
Cell cycle (Georgetown, Tex.) · 2026 · PMID 42070116
Metformin, a first-line antidiabetic drug, has demonstrated anticancer potential in various malignancies, yet its precise mechanisms in hepatocellular carcinoma (HCC) remain incompletely defined. Here, we show that metformin inhibits lipid accumulation and proliferation in HCC cells through modulation of N6-methyladenosine (m6A) RNA methylation. Treatment of HepG2 and Huh7 cells with metformin significantly reduced intracellular triglyceride and cholesterol levels, concomitant with decreased lipid droplet accumulat…
Rank45.0
Other PubMed-indexed publication
Channels (Austin, Tex.) · 2026 · PMID 42084851
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic systemic diseases caused by dengue virus (DENV) and yellow fever virus, neurological complications associated with West Nile virus and Zika virus (ZIKV) infection, as well as liver damage and hepatocellular carcinoma resulting from hepatitis C virus (HCV) infection. …
Rank45.0
Other PubMed-indexed publication
Asia-Pacific journal of oncology nursing · 2026 · PMID 42253413
OBJECTIVE: To dynamically identify latent classes and transition patterns of frailty from the preoperative to the postoperative period in older patients with liver cancer, and to determine the key influencing factors.
METHODS: Between June 2024 and April 2025, a longitudinal study was conducted among 185 older patients with liver cancer at the Second Affiliated Hospital of Kunming Medical University in Yunnan Province. Data were collected using a general information questionnaire, the Fried Frailty Phenotype Scale,…
Rank45.0
Other PubMed-indexed publication
Cell cycle (Georgetown, Tex.) · 2026 · PMID 42272063
Melanoma-associated antigen D4 (MAGED4) belongs to the melanoma-associated antigen family and is upregulated in various cancer types. However, the functional role and molecular mechanisms of MAGED4 in hepatocellular carcinoma (HCC) remain largely unknown. In this study, we observed that MAGED4 expression levels were significantly higher in HCC tissues than in non-cancerous tissues and elevated expression was associated with poor patient outcomes. Functional assays demonstrated that MAGED4 promoted proliferation and…
Rank45.0
Other PubMed-indexed publication
Hepatic oncology · 2026 · PMID 42311093
Transplant Oncology is an evolving field. While liver transplantation was once contraindicated in patients with cancer, the safety and survival benefit of utilizing transplantation as a curative-intent treatment for primary and metastatic hepatic malignancies has been demonstrated. Currently, liver transplantation is offered to selected patients with hepatocellular carcinoma, perihilar and intrahepatic cholangiocarcinoma, colorectal cancer with isolated liver metastases, and neuroendocrine tumors with isolated live…
Rank45.0
Other PubMed-indexed publication
Veterinary record open · 2026 · PMID 42441046
BACKGROUND: On gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) magnetic resonance imaging, canine hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) typically exhibit low and high signal intensities in the hepatobiliary phase, respectively. Reduced transporter protein expression is associated with decreased Gd-EOB-DTPA uptake. However, the specific transporters involved in Gd-EOB-DTPA uptake in canine HCC remain unknown. This exploratory study aimed to assess the mRNA expressi…
Rank45.0
Other PubMed-indexed publication
Artificial cells, nanomedicine, and biotechnology · 2026 · PMID 42482449
BACKGROUND: The aim of this study was to investigate key target(s), mechanism(s) from hepatoma cells in harsh doxorubicin-resistant conditions (DRCs) from GSE125180 datasets in GEO (Gene Expression Omnibus).
METHODS: The identified components can be denoted as a brightness (therapeutic mark) or darkness (resistant mark) in DRCs. The protein-protein interaction (PPI) networks were assembled to identify the relationships between upregulated and downregulated genes via STRING, and R program.
RESULTS: In the |log2 FC| …
Preclinical Research60 records
Rank45.0
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42345510
BACKGROUND AND OBJECTIVE: Microwave ablation is a well-established therapy for liver tumors, but its efficacy is strongly influenced by blood perfusion. Most computational studies simplify perfusion as an isotropic sink, neglecting flow orientation. This work introduces the Antenna-Blood flow Relative Angle (ABRA) to quantify the effects of flow direction and velocity on ablation zone geometry using a commercial ECO Ceramic 14 G antenna.
METHODS: Ex vivo bovine liver experiments were performed under standardized co…
Rank45.0
Other PubMed-indexed publication
Cancer letters · 2026 · PMID 42276407
In colorectal cancer (CRC), tumor-infiltrating regulatory T (Treg) cells suppress anti-tumor immunity, promoting immune evasion and tumor progression. Effective therapies require selectively targeting tumor-infiltrating Treg (TI-Treg) cells while preserving systemic Treg cells, necessitating insight into their adaptations within the tumor microenvironment. Here, CRC-organoids were implanted in the liver of Foxp3eGFP mice to investigate location-specific phenotypic differences in TI-Treg cells. In our cohort, tumor …
Rank43.0
Other PubMed-indexed publicationCorrection flagged
Journal of ethnopharmacology · 2026 · PMID 42142550
ETHNOPHARMACOLOGICAL RELEVANCE: Trametes robiniophila Murr (Huaier) is a traditional Chinese medicine (TCM) with potent immunomodulatory effects. Clinically validated for anti-hepatocellular carcinoma activity, Huaier granules are the mainstream proprietary preparation derived from this fungus. In recent years, polysaccharide components from natural medicinal herbs have attracted extensive research attention owing to their prominent biological activities. Although Huaier has been applied in clinical practice for de…
Rank38.2
Preclinical or laboratory study
Translational oncology · 2026 · PMID 42401103
BACKGROUND: Hepatocellular carcinoma (LIHC) features a complex tumor microenvironment (TME) where tumor-associated neutrophils (TANs) show significant plasticity. The role of aggrephagy-selective autophagy of protein aggregates-in shaping neutrophil heterogeneity and LIHC progression remains poorly understood.
METHODS: We integrated scRNA-seq (183,671 cells), spatial transcriptomics, and bulk datasets (TCGA, GSE39791). Neutrophils (n=12,547) were re-clustered into six subsets, and aggrephagy activity was quantified…
Rank30.0
Preclinical or laboratory study
Bioorganic chemistry · 2026 · PMID 42442295
Vascular endothelial growth factor receptor-2 (VEGFR-2) is a pivotal therapeutic target in combatting tumor angiogenesis and hepatocellular carcinoma (HCC). In the current research, new indolin-2-one and isoindoline-1,3-dione derivatives were prepared as a part of lead optimization strategy, guided by the reported pharmacophoric features of type-II VEGFR-2 inhibitors. Biological evaluation over six human cancer cell lines identified compounds 5, 6a, 6b, 6e, and 6f as potent cytotoxic agents, exhibiting outstanding …
Rank30.0
Preclinical or laboratory study
International immunopharmacology · 2026 · PMID 42302375
BACKGROUND: Immune checkpoint inhibitors (ICIs) show promise in hepatocellular carcinoma (HCC) treatment, but clinical responses remain limited due to immune evasion. CD8+ T-cell dysfunction is a key mechanism of immune evasion in HCC. Interferon-stimulated gene 15 (ISG15), a ubiquitin-like modifier, is implicated in tumor progression, but its role in immune suppression in HCC is unclear.
METHODS: ISG15 expression was analyzed in the TCGA-LIHC cohort, and its correlation with prognosis, immune infiltration, and che…
Rank30.0
Preclinical or laboratory study
International immunopharmacology · 2026 · PMID 42250289
CAR T cell therapy has demonstrated remarkable antitumor efficacy in hematologic malignancies, but its application in solid tumors remains challenging. This is primarily due to the suppressive tumor microenvironment, which impedes T cell infiltration and reduces their functionality. Compared with standard intravenous administration, localized delivery strategies offer significant promise for CAR T therapy in solid tumors. Nevertheless, most reported approaches rely on complex biomaterials and are mainly applied in …
Rank30.0
Preclinical or laboratory study
European journal of medicinal chemistry · 2026 · PMID 42134161
The fibroblast growth factor receptors (FGFRs) have garnered considerable attention as promising therapeutic targets in oncology, given their pivotal involvement in regulating cell proliferation, differentiation, and various other physiological processes. In this study, we have designed and synthesized a series of FGFR inhibitors featuring the 3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one scaffold as a core structural motif. Notably, among these derivatives, compound 1a emerged as a potent inhibitor of four distinct …
Rank30.0
Preclinical or laboratory study
Molecular therapy. Oncology · 2026 · PMID 42441112
Hepatocellular carcinoma (HCC), a leading cause of cancer death, has a dynamic and heterogeneous tumor microenvironment (TME) that drives progression and therapeutic resistance. We previously elucidated that apoptosis-antagonizing transcription factor (AATF) drives angiogenesis in HCC. However, its role in TME remains unexplored. We employed an orthotopic xenograft mouse model, implanting human HCC cells into the liver and achieved liver-specific silencing via tail vein injection of adeno-associated virus 8 (AAV8) …
Rank30.0
Preclinical or laboratory study
Biochimica et biophysica acta. Molecular basis of disease · 2026 · PMID 42242436
Resistance to molecular-targeted agents, represented by sorafenib (SOR), poses a major challenge in the treatment of hepatocellular carcinoma (HCC). Huaier (HUA), a traditional Chinese medicine used as an adjuvant cancer therapy, has demonstrated favorable efficacy in clinical practice for advanced HCC. This study demonstrates that HUA reverses SOR resistance in HCC and exhibits synergistic effects with SOR by modulating NCOA4-mediated ferritinophagy, thereby influencing iron and lipid metabolic pathways associated…
Rank30.0
Preclinical or laboratory study
Cellular signalling · 2026 · PMID 42285192
Mounting evidence has suggested that enhancer RNAs (eRNAs) play vital roles in tumor progression. However, the molecular mechanisms of eRNAs involvement in the occurrence and development of hepatocellular carcinoma (HCC) remain to be explored. Herein, bioinformatics analysis was used to screen a new differential expression eRNA in HCC, namely AL109933.1. Moreover, A series of in vitro and in vivo experiments were performed to evaluate the biological significance and potential mechanism of AL109933.1 in HCC. The res…
Rank30.0
Preclinical or laboratory study
Cellular signalling · 2026 · PMID 42364863
Ferroptosis, an iron-dependent form of regulated cell death, plays a pivotal role in hepatocellular carcinoma (HCC) progression and is now recognized as a key mechanism underlying the antitumor activity of sorafenib. Src homology and collagen protein 4 (SHC4), an adaptor protein implicated in oncogenic signaling and tumor progression, has recently emerged as a potential regulator in multiple cancers; however, its involvement in ferroptosis and sorafenib response remains unclear. Our preliminary data showed that sor…
Rank30.0
Preclinical or laboratory study
Cellular signalling · 2026 · PMID 42349706
The role of the nuclear pore protein NUP54 in tumorigenesis and progression remains unclear. By integrating multiomics data from TCGA, GTEx, CPTAC, and other sources, in this study, the first pan-cancer landscape of NUP54 was systematically delineated: its mRNA and protein expression levels are significantly upregulated in most types of cancer, including lung adenocarcinoma, hepatocellular carcinoma, and gastric cancer. It has a high diagnostic value across several types of cancer, including cholangiocarcinoma and …
Rank30.0
Preclinical or laboratory study
Computational biology and chemistry · 2026 · PMID 42048949
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) often recurs as lethal liver metastasis, but the molecular factors that facilitate hepatic colonization remain unclear.
METHODS: Transcriptomic data from 9 primary PDAC tumors and 12 liver metastases (GSE19279 and GSE42952) were integrated with 2420 lactate-related genes (LRGs). Differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA), and survival analysis were employed to identify key genes. Analyzing hub genes using a single-c…
Rank30.0
Preclinical or laboratory study
Journal of ethnopharmacology · 2026 · PMID 42276390
ETHNOPHARMACOLOGICAL RELEVANCE: Rheum officinale Baill. (Dahuang, DH) was first documented in the Shennong Bencaojing (Shennong's Classic of Materia Medica), and used in traditional Chinese medicine to purge accumulation, clear heat, and detoxify. Modern research confirms the anti-inflammatory, antioxidant, and anti-tumor properties. However, the anti-tumor mechanisms remained unclear in hepatocellular carcinoma.
AIM OF THE STUDY: To investigate the mechanism by which DH inhibits the growth of liver cancer.
MATERIA…
Rank30.0
Preclinical or laboratory study
Bioactive materials · 2026 · PMID 42256886
Long-term liver injury leads to acute hepatitis and chronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC), which frequently necessitate liver transplantation and are associated with poor median survival. Transforming growth factor-β (TGF-β) signalling pathway is a key driver of fibrogenesis and tumor progression. Therapeutic approaches targeting this pathway-via TGF-β receptor blockade or inhibition of its chaperone protein Hsp90- are under pre-clinical and clinical trials, and despite some …
Rank30.0
Preclinical or laboratory studyResult signal: benefit
Drug delivery · 2026 · PMID 42249613
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, yet conventional chemotherapy is limited by poor tumor specificity and severe toxicity. Cantharidin (CTD), a natural antitumor agent, is hindered by nephrotoxicity and hepatotoxicity. This study aimed to construct a dual-ligand-modified CTD-loaded solid lipid nanoparticle (GA-FA-CSLNs) using 18-glycyrrhetinic acid (GA) for hepatocyte targeting and folate-PEG3500-DSPE (FA) for long circulation, and to evaluate its antitumor efficacy, mech…
Rank30.0
Preclinical or laboratory study
Biomaterials · 2026 · PMID 42218110
Hepatocellular carcinoma (HCC) may be curable when detected and at an early stage. However, recurrence and metastatic progression occur frequently following therapeutic intervention, leading to treatment-refractory disease. Such refractory HCCs are resistant to systemic therapies, facilitating metastatic dissemination and disease relapse, highlighting the need for alternative therapeutic strategies. To address the limited efficacy of available systemic therapies, we developed a new polyaspartic acid (PASP) based po…
Rank30.0
Preclinical or laboratory study
Journal of ethnopharmacology · 2026 · PMID 42178078
ETHNOPHARMACOLOGICAL RELEVANCE: The compounds reviewed here originate from plants with long-standing use in East Asian traditional medicine. Epimedium brevicornu Maxim. (Yin Yang Huo), Scutellaria baicalensis Georgi (Huang Qin), Coptis chinensis Franch. (Huang Lian), and Curcuma longa L. (Jiang Huang) are documented in the Chinese pharmacopoeia for indications including liver insufficiency, heat-clearing, and abdominal masses-a traditional category encompassing hepatic tumours.
AIM OF THE STUDY: To examine how trad…
Rank30.0
Preclinical or laboratory study
Biomaterials · 2026 · PMID 42139921
Mechanical and structural cues of the extracellular matrix (ECM) regulate tumor cell metabolism and drug response, yet the molecular mediators that link these biophysical signals are unclear. We present an elastically supported surface platform bioengineered with varying stiffness and collagen fiber anisotropy to replicate the fibrotic and mechanically inhomogeneous liver cancer microenvironment. Using this system, we identify Kelch-like ECH-associated protein 1 (KEAP1) as a mechanoresponsive mediator linking ECM s…
Rank30.0
Preclinical or laboratory study
Cancer biology & therapy · 2026 · PMID 42124320
BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by high recurrence rates and limited targeted therapies. Centromere protein I (CENPI), a core kinetochore component linked to chromosomal instability, is dysregulated in multiple malignancies, yet its role and mechanism in HCC progression remain incompletely elucidated.
METHODS: CENPI expression was quantified in paired human HCC tissues and orthotopic rat HCC models via immunohistochemistry (IHC) and western blot (WB). Gain- and loss-of-function assays we…
Rank30.0
Preclinical or laboratory study
Gut microbes · 2026 · PMID 42108649
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population and can progress to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis, increasing the risk of cirrhosis, hepatocellular carcinoma, and mortality. Gut microbes driven by diets high in saturated fat, simple sugar, and cholesterol contribute to disease progression, yet the underlying mechanisms remain undefined. We explored the independent and synergistic effects of dietary satu…
Rank30.0
Preclinical or laboratory study
Toxicology and applied pharmacology · 2026 · PMID 42303055
Hepatocellular carcinoma (HCC) is a type of highly prevalent malignancy characterized by poor prognosis and high rates of recurrence and metastasis. Corynoxine (Cory), a natural alkaloid extracted from Uncaria rhynchophylla, has been identified as an autophagy enhancer. Nevertheless, the biological function of Cory in HCC is yet to be determined. This study aimed to investigate the anti-tumor effects and underlying mechanisms of Cory in HCC using HepG2 and Huh7 cell lines, as well as a xenograft mouse model. Our re…
Rank30.0
Preclinical or laboratory study
The Journal of nutritional biochemistry · 2026 · PMID 42009112
Carnosic acid (CA), a phenolic diterpene abundant in Rosmarinus officinalis, has emerged as a bioactive compound with multifaceted effects on hepatic cells and liver tissue. The present work aims to critically discuss, from a mechanistic perspective, the molecular and cellular effects induced by CA on the liver, integrating evidence from in vitro and in vivo experimental models. Across hepatocytes, hepatic stellate cells, and hepatocellular carcinoma models, CA consistently modulates redox balance, inflammatory sig…
Rank30.0
Preclinical or laboratory study
Cellular signalling · 2026 · PMID 42217552
BACKGROUND: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with a poor prognosis and limited therapeutic options. There is a pressing need to identify novel prognostic biomarkers and therapeutic targets, particularly among secreted proteins which play critical roles in tumor progression and the tumor microenvironment.
METHODS: We conducted an integrated bioinformatic analysis of transcriptomic data from TCGA-LIHC and GEO datasets to identify dysregulated secretory proteins and construct a prognost…
Promising Experimental Therapies60 records
Rank110.0
Clinical guideline or consensus statement
Journal of hepatology · 2026 · PMID 42191458
Steatotic liver disease (SLD) comprises a heterogeneous group of liver diseases defined by pathological hepatic lipid accumulation with varying degrees of steatohepatitis and progressive fibrosis, which may culminate in cirrhosis and/or hepatocellular carcinoma. SLD encompasses metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called non-alcoholic fatty liver disease (NAFLD); MetALD, describing patients with MASLD consuming moderately high amounts of alcohol; and alcohol-associated/related …
Rank96.7
Randomized controlled trial
The lancet. Gastroenterology & hepatology · 2026 · PMID 42330996
BACKGROUND: Patients with unresectable hepatocellular carcinoma have a poor prognosis and treatments with long-term benefits are needed. Anti-PD-L1 or anti-PD-1 plus anti-VEGF or anti-CTLA-4 double combinations are validated, first-line, systemic immunotherapies. We report the preplanned phase 2 results of the phase 2-3 PRODIGE 81-FFCD 2101-TRIPLET-HCC trial investigating the survival outcomes and safety profile of a triple combination of atezolizumab, bevacizumab, and ipilimumab in a first-line setting.
METHODS: T…
Rank91.4
Randomized clinical study
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 42008357
PURPOSE: Immune checkpoint inhibitors (ICI) can induce long-term survival and even cancer cure in several cancers. Mixture cure models (MCM) estimate the fraction of long-term survivors and cured patients but have not been applied in hepatocellular carcinoma (HCC).
EXPERIMENTAL DESIGN: We identified phase III randomized trials of first-line ICI in advanced HCC with mature follow-up (≥30 months) and analyzed a cohort of patients with HCC treated with atezolizumab-bevacizumab. After reconstructing Kaplan-Meier curves…
Rank83.1
Phase II clinical trial
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 42126314
PURPOSE: Evidence for radiotherapy (RT) in oligoprogressive hepatocellular carcinoma (OP-HCC) is limited. We evaluated the efficacy and safety of progression-directed RT (PDRT) alongside ongoing first-line systemic therapy (FLST) in patients with OP-HCC.
PATIENTS AND METHODS: Patients who developed OP-HCC during FLST were enrolled and received PDRT with a biologically effective dose of at least 60 Gy while continuing FLST. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall su…
Rank80.1
Phase II clinical trial
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026 · PMID 42385524
AIMS: It is controversial whether monotherapy with immunotherapeutics is effective in early-stage hepatocellular carcinoma (HCC). We evaluated immunotherapy monotherapy as an initial neoadjuvant strategy.
METHODS: This prospective, single-arm, phase II trial of an adaptive neoadjuvant strategy enrolled patients with resectable, early-stage HCC. All patients received tislelizumab monotherapy; non-responders received subsequent lenvatinib combination therapy preoperatively.
RESULTS: For the overall efficacy of all 36…
Rank79.5
Phase II clinical trial
European journal of cancer (Oxford, England : 1990) · 2026 · PMID 42284972
BACKGROUND: Combinations of anti-angiogenic agents, including lenvatinib, and PD-1/PD-L1 inhibitors have demonstrated antitumor activity with manageable toxicity in several tumor types, including hepatocellular carcinoma (HCC).
OBJECTIVE: The IMMUNIB trial aimed to evaluate efficacy of nivolumab in combination with lenvatinib as first-line treatment in patients with unresectable HCC.
DESIGN: This investigator-initiated single-arm phase-2 trial enrolled patients with advanced stage HCC for first-line therapy who wer…
Rank77.0
Phase II clinical trial
Journal of hepatology · 2026 · PMID 41763363
BACKGROUND & AIMS: Liver transplantation (LT) is a curative treatment option in early and intermediate hepatocellular carcinoma (HCC) following downstaging with locoregional therapies (LRT). Tumor response to immune checkpoint inhibitors may extend LT eligibility to intermediate and advanced stages.
METHODS: In this prospective phase II study, patients with intermediate and advanced HCCs beyond extended transplant criteria, not amenable to further LRTs, were downstaged with atezolizumab-bevacizumab (Atezo-Bev) prio…
Rank66.8
Phase I clinical trialResult signal: benefit
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 41984885
PURPOSE: Although immunotherapy regimens have significantly improved treatment options for patients with advanced hepatocellular carcinoma (HCC), the optimal use of these regimens in earlier disease stages remains poorly defined.
PATIENTS AND METHODS: We conducted a single-institution, single-arm pilot study (NCT04857684) of neoadjuvant stereotactic body radiotherapy (SBRT) followed by 2 cycles of atezolizumab plus bevacizumab and subsequent surgical resection in patients with initially resectable HCC (n = 8). The …
Rank51.5
Other PubMed-indexed publicationResult signal: benefit
Journal for immunotherapy of cancer · 2026 · PMID 42336655
PURPOSE: Liver metastases (LMs) confer resistance to immune checkpoint blockade in advanced non-squamous non-small cell lung cancer (ns-NSCLC), likely through an immunosuppressive tumor microenvironment (TME). We hypothesized that vascular endothelial growth factor (VEGF)-A blockade, by remodeling the immunosuppressive TME, could restore the benefit of chemoimmunotherapy in LM+ patients. Here, we report the first comparative analysis of chemoimmunotherapy with and without bevacizumab specifically in this population…
Rank49.1
Other PubMed-indexed publication
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 41973053
PURPOSE: Resection of liver metastases improves survival in patients with metastatic colorectal cancer (mCRC) with liver-limited disease (LLD), but relapse remains common. Postresection circulating tumor DNA (ctDNA) is a valid prognostic biomarker; however, no data are available regarding the prognostic effect of presurgery ctDNA after upfront chemotherapy.
EXPERIMENTAL DESIGN: Patients (N = 116) with initially unresectable mCRC with LLD who underwent resection after upfront chemotherapy were included. Patients wer…
Rank47.0
Other PubMed-indexed publication
Journal of clinical laboratory analysis · 2026 · PMID 42403196
OBJECTIVE: This study aimed to investigate the expression patterns and prognostic significance of insulin-like growth factor-binding protein 3 (IGFBP3) in hepatocellular carcinoma (HCC) and other cancer types.
METHODS: IGFBP3 expression was analyzed using The Cancer Genome Atlas (TCGA)-LIHC, International Cancer Genome Consortium (ICGC-LIRI-JP), Gene Expression Omnibus (GEO; GSE102079 and GSE112790), and Genotype-Tissue Expression (GTEx) databases. Experimental validation included immunohistochemistry (IHC) and qua…
Rank45.0
Other PubMed-indexed publication
PLoS computational biology · 2026 · PMID 42330082
The crosstalk between lactylation and autophagy within the hepatocellular carcinoma (HCC) microenvironment is a burgeoning field with profound implications. By integrating multi-omics data from public cohorts, we delineated two molecular subtypes of HCC with divergent clinical outcomes and established a lactylation-autophagy-related prognostic signature. This signature highlighted CLEC3B as a pivotal gene. Subsequent single-cell RNA sequencing and experimental validation unequivocally pinpointed liver sinusoidal en…
Rank45.0
Other PubMed-indexed publication
PeerJ · 2026 · PMID 42369747
Conflict between humans and carnivores, known as Human-Carnivore Conflict (HCC), has existed throughout history, with recent escalations attributed to anthropogenic expansion and intensified resource competition. Conflict with carnivores primarily stems from livestock depredation, resulting in economic losses that threaten livelihoods. These conflicts pose significant challenges for affected human communities and carnivore conservation. Non-lethal mitigation strategies, particularly livestock guardian animals (LGAs…
Rank45.0
Other PubMed-indexed publication
International journal of molecular sciences · 2026 · PMID 42449971
Hepassocin, also known as fibrinogen-like protein 1 (FGL-1), is a liver-derived secretory protein initially identified as a mitogenic factor involved in hepatocyte proliferation and liver regeneration. Increasing evidence has subsequently suggested that FGL-1 functions as a hepatokine linking hepatic metabolic stress to systemic metabolic regulation. Experimental and clinical studies have demonstrated that circulating FGL-1 levels are associated with obesity, insulin resistance, metabolic dysfunction-associated ste…
Rank45.0
Other PubMed-indexed publication
Molecular biology reports · 2026 · PMID 42377685
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common causes of death around the world, and it is commonly diagnosed late, so systemic chemotherapy is commonly used. Lysosomal sequestration of chemotherapy drugs such as sorafenib [1] decreases the effective concentration of chemotherapy at the target sites and leads to chemoresistance, also chemoresistance may arise from autophagy activation. We aimed to find a new therapeutic regimen for HCC through enhancing the chemosensitivity of SB by combining …
Rank45.0
Other PubMed-indexed publication
Hepatology (Baltimore, Md.) · 2026 · PMID 39808821
Preventive interventions are expected to substantially improve the prognosis of patients with primary liver cancer, predominantly HCC and cholangiocarcinoma. HCC prevention is challenging in the face of the evolving etiological landscape, particularly the sharp increase in obesity-associated metabolic disorders, including metabolic dysfunction-associated steatotic liver disease. Next-generation anti-HCV and HBV drugs have substantially reduced, but not eliminated, the risk of HCC and have given way to new challenge…
Rank45.0
Other PubMed-indexed publication
Biomaterials · 2026 · PMID 41619660
Chronic hypoxia is a critical barrier to the effective treatment of solid tumors, including hepatocellular carcinoma (HCC), as it not only restricts the oxygen supply required for sonodynamic therapy (SDT) but also upregulates hypoxia-inducible factor-2α (HIF-2α), thereby accelerating tumor progression, inducing abnormal angiogenesis, suppressing antitumor immune responses, and diminishing the efficacy of targeted therapies. Here, we developed an intelligent switchable organic-inorganic hybrid nanoplatform (VitK3/P…
Rank45.0
Other PubMed-indexed publication
Critical reviews in oncology/hematology · 2026 · PMID 42086130
Secondary resistance remains a major clinical hurdle in advanced hepatocellular carcinoma (HCC), despite the paradigm shift toward combining tyrosine kinase inhibitors (TKIs) with immune checkpoint inhibitors (ICIs). Existing literature largely focuses on static microenvironmental factors or tumor-intrinsic mutations. The potential role of efferocytosis-driven metabolic reprogramming as a theoretical link between TKI-induced cell death and immune tolerance remains a critical conceptual gap. Addressing this gap, thi…
Rank45.0
Other PubMed-indexed publication
Liver international : official journal of the International Association for the Study of the Liver · 2026 · PMID 42188461
Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol-associated liver disease and metabolic dysfunction-associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may progress to cirrhosis, hepatic decompensation and hepatocellular carcinoma. Despite advances in etiological treatments, effective therapies for established fibrosis remain limited. I…
Rank45.0
Other PubMed-indexed publication
Journal of biochemical and molecular toxicology · 2026 · PMID 42346026
Hepatocellular carcinoma (HCC) is an aggressive cancer with poor prognosis and high mortality rates. The increasing mortality associated with HCC highlights the urgent need for alternative therapeutic approaches. Natural products and their structural analogs have shown promise as novel treatment options. This study aimed to evaluate the potential therapeutic effects of the natural flavonoids apigenin and chrysin, administered individually and in combination, in an experimental HCC model. Forty-eight rats were divid…
Rank45.0
Other PubMed-indexed publication
In vivo (Athens, Greece) · 2026 · PMID 42379766
BACKGROUND/AIM: Expanding the ablation area remains a critical challenge in the treatment of hepatocellular carcinoma. Herein, we investigated the utility of various radiofrequency ablation (RFA) protocols for increasing ablation areas, using the bovine liver as a model.
MATERIALS AND METHODS: A bovine liver (7.2 kg) placed in a stainless-steel tray was subjected to RFA using an arfa 17-G electrode. The starting and increment wattages were varied in the linear mode. RFA was stopped after one break. The size of the …
Rank45.0
Other PubMed-indexed publication
Journal of medical virology · 2026 · PMID 42478159
Chimpanzees are the only non-human species susceptible to hepatitis C virus (HCV) infection and have served as models in HCV pathogenesis and antiviral drug development. Despite this, the long-term clinical consequences of chronic infection and therapeutic efficacy of direct-acting antivirals (DAAs) in this species are poorly documented. We evaluated the virologic, biochemical, and clinical outcomes of DAA therapy in eight captive chimpanzees with experimental HCV infection, with a median infection duration of 36 y…
Rank45.0
Other PubMed-indexed publication
Nutrients · 2026 · PMID 42514283
Introduction: Hepatic fibrosis represents a critical intermediate stage in the progression from chronic liver disease to cirrhosis and ultimately hepatocellular carcinoma. Spirulina platensis, a microorganism rich in bioactive compounds, contains several functional components, among which are Spirulina polysaccharides and phycocyanin. Both have been demonstrated to exhibit multiple biological activities, including antioxidant, anti-inflammatory, and immunomodulatory effects. However, the intervention effects and me…
Rank45.0
Other PubMed-indexed publication
Frontiers in immunology · 2026 · PMID 42495610
BACKGROUND: Chromosome 17 Open Reading Frame 75 (C17orf75) encodes the protein Njmu-R1 (Protein Njmu-R1),, which is involved in intracellular vesicle trafficking; however, its role in tumor progression remains largely unclear.
METHODS: Public datasets from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and the Human Protein Atlas (HPA) were analyzed to evaluate the expression profile, mutation landscape, and diagnostic and prognostic value of C17orf75. Bioinformatics analyses were subsequently perfo…
Rank45.0
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42345510
BACKGROUND AND OBJECTIVE: Microwave ablation is a well-established therapy for liver tumors, but its efficacy is strongly influenced by blood perfusion. Most computational studies simplify perfusion as an isotropic sink, neglecting flow orientation. This work introduces the Antenna-Blood flow Relative Angle (ABRA) to quantify the effects of flow direction and velocity on ablation zone geometry using a commercial ECO Ceramic 14 G antenna.
METHODS: Ex vivo bovine liver experiments were performed under standardized co…
Prospective Cohort Studies61 records
Rank104.1
Systematic review or meta-analysis
Journal of gastrointestinal cancer · 2026 · PMID 42213206
BACKGROUND: Liver transplantation (LT) has emerged as a potential treatment option for selected patients with colorectal liver metastases (CRLM), but existing meta-analyses are limited by heterogeneous populations and mixed treatment modalities.
METHODS: A systematic review and single-arm meta-analysis were conducted in accordance with PRISMA guidelines. Studies reporting outcomes following LT for CRLM were included. Primary outcomes were overall survival (OS) and progression-free survival (PFS) at predefined time …
Rank101.2
Systematic review or meta-analysisResult signal: harm
JAMA network open · 2026 · PMID 42268607
IMPORTANCE: Artificially sweetened beverages (ASBs) and sugar-sweetened beverages (SSBs) are widely consumed worldwide and have been linked to metabolic disorders, including obesity and type 2 diabetes, which are established risk factors associated with liver cancer. However, prospective evidence examining beverage consumption and liver cancer subtypes remains limited and inconsistent.
OBJECTIVE: To examine associations between ASB and SSB consumption and risk of incident liver cancer overall and by subtype, includ…
Rank92.4
Randomized clinical study
Langenbeck's archives of surgery · 2026 · PMID 42307778
BACKGROUND: Posthepatectomy liver failure (PHLF) remains the most lethal complication after liver resection. This study aimed to identify preoperative and intraoperative risk factors for PHLF following open hepatectomy using data derived from prospective clinical trials.
METHODS: A pooled secondary analysis of five prospective studies - four randomized controlled trials and one prospective cohort study - was performed, including 515 patients who underwent elective open liver resection between 2007 and 2017 at two h…
Rank89.2
Randomized clinical study
BMJ open · 2026 · PMID 42493202
INTRODUCTION: Liver resection is a technically demanding procedure due to the complex and highly variable anatomy of the liver. Conventional preoperative planning relies on two-dimensional imaging, which requires mental reconstruction of three-dimensional anatomical relationships and may increase cognitive workload and intraoperative decision-making time. Patient-specific three-dimensional (3D) liver mapping has been shown to improve anatomical understanding and planning accuracy; however its impact on intraoperati…
Rank89.2
Randomized clinical study
BMJ open · 2026 · PMID 42264528
INTRODUCTION: Treatment options remain limited for patients with advanced hepatocellular carcinoma (HCC) who experience oligoprogression during first-line systemic therapy (FLST), especially given the modest efficacy and restricted availability of second-line systemic therapy (SLST). This trial aims to evaluate whether continuing FLST combined with radiotherapy (RT) to oligoprogressive lesions can improve progression-free survival (PFS) compared with an early switch to SLST in patients with oligoprogressive HCC whi…
Rank88.0
Randomized clinical study
Cancer medicine · 2024 · PMID 38629255
BACKGROUND: More than half of neuroendocrine tumor (NET) patients will experience liver metastasis, and interventional therapy represented by transarterial embolization (TAE) is the main local treatment method. Surufatinib is recommended as a standard systemic treatment for advanced NETs. The efficacy and safety of surufatinib combined with TAE in the treatment of liver metastasis are undetermined. This study was conducted to compare the clinical outcome of surufatinib combined with TAE versus surufatinib monothera…
Rank82.4
Multicenter clinical study
Radiology · 2026 · PMID 42117996
Background Intratumoral fibrosis (ITF) may influence the prognosis of hepatocellular carcinoma (HCC) and transarterial chemoembolization (TACE) efficacy. However, pretreatment biopsies are not routinely performed for HCC. Purpose To develop and validate a CT-based radiomics model to classify ITF grade in HCC and to evaluate the associations of model ITF classifications with post-TACE prognosis and tumor angiogenesis levels. Materials and Methods This multicenter study (August 2013 to November 2023) included five re…
Rank81.0
Multicenter clinical study
Alimentary pharmacology & therapeutics · 2026 · PMID 42017265
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits marked heterogeneity in fibrosis progression and liver-related outcomes. Liver biopsy is not feasible for longitudinal risk stratification at scale, creating a need for validated non-invasive biomarkers, particularly imaging biomarkers, that can predict clinically meaningful disease progression and liver-related outcomes.
AIMS: To describe the design and rationale of the GOLDMINE study, established to determine whether non-invasiv…
Rank80.1
Phase II clinical trial
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026 · PMID 42385524
AIMS: It is controversial whether monotherapy with immunotherapeutics is effective in early-stage hepatocellular carcinoma (HCC). We evaluated immunotherapy monotherapy as an initial neoadjuvant strategy.
METHODS: This prospective, single-arm, phase II trial of an adaptive neoadjuvant strategy enrolled patients with resectable, early-stage HCC. All patients received tislelizumab monotherapy; non-responders received subsequent lenvatinib combination therapy preoperatively.
RESULTS: For the overall efficacy of all 36…
Rank79.5
Multicenter clinical study
Annals of surgical oncology · 2026 · PMID 41926013
BACKGROUND: Enhanced recovery programs (ERPs) improve short-term outcomes after liver surgery (LS), but their impact on survival remains uncertain. This study evaluated the association between ERP compliance and survival in a large multicenter cohort.
METHODS: This prospective European multicenter cohort included adults undergoing elective LS between 2016 and 2024 in 10 centers implementing Enhanced Recovery After Surgery (ERAS)-consistent ERPs. Compliance was defined as the proportion of 21 fulfilled items with hi…
Rank79.1
Multicenter clinical study
Clinical and translational medicine · 2026 · PMID 42145083
BACKGROUND AND AIMS: Existing imaging and serum-marker assays miss many early liver cancers, especially in high-risk chronic liver disease carriers. We aimed to create a highly accurate, non-invasive, methylation-based liquid biopsy for early detection.
METHODS: We used a comprehensive, multi-platform, multi-cohort strategy for marker discovery, starting with methylation profiling of hepatocellular carcinoma samples from TCGA and in-house cohorts. From 30 initial candidates, nine highly liver-specific methylation m…
Rank77.7
Multicenter clinical study
BMJ open · 2026 · PMID 42486514
INTRODUCTION: Hepatocellular carcinoma is the sixth most common malignancy worldwide, with immune checkpoint inhibitors transforming treatment paradigms despite modest response rates of approximately 30%. Emotional distress, encompassing depression and anxiety symptoms, affects 30-50% of cancer patients and may influence immunotherapy efficacy through immune system modulation. Recent studies in lung cancer, gastric cancer and melanoma demonstrate associations between pretreatment emotional distress and worse immuno…
Rank77.3
Multicenter clinical study
Ultrasound in medicine & biology · 2026 · PMID 41934080
OBJECTIVE: Given the high hypoenhancement prevalence of hepatic hemangiomas (HHs) during the transitional phase and Kupffer phase (KP) of Sonazoid contrast-enhanced ultrasound (CEUS), this study aimed to investigate the hypoenhancement phenomenon pattern and its influencing factors.
METHODS: This was a prospective multicenter study. A total of 136 patients with HHs were enrolled from 26 medical centers, including 76 cases in the KP hypoenhancement group and 60 cases in the KP non-hypoenhancement group. Enhancement …
Rank77.2
Multicenter clinical study
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026 · PMID 41439463
OBJECTIVE: To investigate the value of transitional phase characteristics on Sonazoid contrast-enhanced ultrasound (S-CEUS) in the differential diagnosis of common focal liver lesions (FLLs).
MATERIALS AND METHODS: This prospective multicenter study enrolled 122 participants with FLLs from 8 medical centers between December 2023 and March 2025. The study comprised 43 cases of hepatic hemangioma (HH), 35 cases of hepatocellular carcinoma (HCC), and 44 cases of liver metastases (LM). All participants underwent standa…
Rank77.0
Phase II clinical trial
Journal of hepatology · 2026 · PMID 41763363
BACKGROUND & AIMS: Liver transplantation (LT) is a curative treatment option in early and intermediate hepatocellular carcinoma (HCC) following downstaging with locoregional therapies (LRT). Tumor response to immune checkpoint inhibitors may extend LT eligibility to intermediate and advanced stages.
METHODS: In this prospective phase II study, patients with intermediate and advanced HCCs beyond extended transplant criteria, not amenable to further LRTs, were downstaged with atezolizumab-bevacizumab (Atezo-Bev) prio…
Rank77.0
Phase II clinical trial
Signal transduction and targeted therapy · 2026 · PMID 42135293
Despite numerous available treatment options, the overall prognosis for patients with unresectable hepatocellular carcinoma (uHCC) remains poor. This study aimed to evaluate the efficacy and safety of combining hepatic arterial infusion chemotherapy with FOLFOX (FOLFOX-HAIC), lenvatinib, and the PD-L1 inhibitor durvalumab in this population, with all uHCC patients receiving the triple-combination regimen as initial therapy. The primary objective was progression-free survival (PFS), and secondary outcomes included o…
Rank76.9
Multicenter clinical study
Gut and liver · 2026 · PMID 41944032
BACKGROUND/AIMS: Optimal second-line (2L) and third-line (3L) systemic therapies after first-line (1L) atezolizumab plus bevacizumab (AtezoBev) for advanced hepatocellular carcinoma (HCC) remain undefined. This prospective multicenter study evaluated the efficacy and safety of various 2L and 3L systemic therapies following AtezoBev.
METHODS: We enrolled 94 patients with advanced HCC who were intolerant of or progressed to 1L AtezoBev treatment from four hospitals in Korea. Five patients who did not receive 2L thera…
Rank75.6
Multicenter clinical study
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026 · PMID 41989878
BACKGROUND: Patients with human immunodeficiency virus (HIV) infection have been gradually accepted as solid organ transplant recipients, although there is still concern that the burden of immunosuppression and HIV infection could increase the risk of post-transplant cancer.
METHODS: The risk of de novo cancer was evaluated in a prospective cohort of 272 HIV-positive and 816 matched HIV-negative liver transplant recipients in Spain (2002-2012). All tumors, except hepatocellular carcinoma recurrence and non-melanoma…
Rank74.7
Prospective cohort study
JHEP reports : innovation in hepatology · 2026 · PMID 42092283
BACKGROUND & AIMS: Sex-specific associations between adiposity and death from primary liver cancer (PLC) remain poorly characterized, particularly those related to emerging anthropometric indices and populations with high abdominal adiposity.
METHODS: In two prospective cohort studies, the sex-specific associations between 16 anthropometric indices (six traditional, 10 emerging) and PLC death were examined in 72,691 women and 59,892 men in China. Cox proportional hazards regression models with restricted cubic spli…
Rank70.4
Prospective cohort study
Alimentary pharmacology & therapeutics · 2026 · PMID 41933428
BACKGROUND: Chronic hepatitis B (CHB) virus infection is the leading cause of hepatocellular carcinoma (HCC). Nucleos(t)ide analogs (NAs) effectively suppress HBV replication, but residual HCC risk remains in treated patients, highlighting the need for reliable risk stratification tools. Existing prediction models rely heavily on age and liver function parameters and often overlook hepatitis B surface antigen (HBsAg) quantification, a key marker closely tied to HBV-related HCC, resulting in inadequate clinical pred…
Rank70.0
Multicenter clinical study
Anticancer research · 2026 · PMID 42373279
BACKGROUND/AIM: This study aimed to verify the efficacy and safety of balloon-occluded alternative infusion of cisplatin solution and gelatin particles of transarterial chemoembolization (BOAI-TACE) for hepatocellular carcinoma (HCC) refractory or intolerant to atezolizumab plus bevacizumab combination therapy.
PATIENTS AND METHODS: This prospective, single-arm study was performed at five hospitals from May 2021 to December 2024. The primary endpoint was objective response ratio (ORR) for BOAI-TACE at eight weeks a…
Rank69.4
Prospective cohort studyResult signal: mixed
Diabetes, obesity & metabolism · 2026 · PMID 42107989
AIMS: Cirrhosis and hepatocellular carcinoma are severe major adverse liver outcomes (MALOs) of metabolic dysfunction-associated steatotic liver disease (MASLD), yet the relationship between proteomics and MALOs remains unclear. This study aimed to identify plasma proteomic features associated with MALOs and evaluate the potential of proteomics to enhance the prediction of MALOs risks in individuals with MASLD.
MATERIALS AND METHODS: This prospective cohort study included 14 166 participants with MASLD from the UK …
Rank66.6
Observational or cohort studyResult signal: harm
Chirurgia (Bucharest, Romania : 1990) · 2026 · PMID 42478984
Background: Sarcopenia is a common complication and an important negative prognostic factor in patients with liver cirrhosis, being associated with reduced muscle mass and function, as well as increased mortality. Although computed tomography (CT) is considered the gold standard for assessing muscle mass, there is growing interest in identifying serum biomarkers that may facilitate the early diagnosis and monitoring of disease progression. The aim of this study was to evaluate the diagnostic value of osteonectin, t…
Rank65.0
Prospective cohort studyResult signal: harm
Scientific reports · 2026 · PMID 42069906
Light pollution has been implicated in liver health. This study aimed to investigate the association between bedroom nighttime light pollution and the risk of hepatic encephalopathy (HE) in patients with hepatocellular carcinoma (HCC). A total of 454 HCC patients were enrolled from communities. Bedroom nighttime light intensity was measured using an illuminometer (lux) at baseline, 2 months, and 4 months. Sleep quality was assessed at these three time points using the Pittsburgh Sleep Quality Index. These data at d…
Rank65.0
Prospective cohort studyResult signal: harm
Environmental pollution (Barking, Essex : 1987) · 2026 · PMID 42069119
Whether secondhand smoke (SHS) exposure confers an increased risk of liver cancer remains elusive, and no epidemiological studies have examined the potential impact of thirdhand smoke (THS) exposure on the risk of this cancer. Therefore, we aimed to examine the potential associations of SHS and THS exposure with the risk of liver cancer. A population-based cohort of 315,833 Chinese never smokers was identified from the China Kadoorie Biobank. SHS and THS exposure were assessed by the retrospective self-reports. Mul…
Quality Of Life60 records
Rank107.9
Systematic review or meta-analysis
Frontiers in oncology · 2026 · PMID 42222418
OBJECTIVE: To assess the reporting characteristics and quality of patient-reported outcomes (PROs) in randomized controlled trials (RCTs) of targeted therapy and/or immunotherapy for liver cancer.
METHODS: We systematically searched six electronic databases for relevant RCTs published in English or Chinese from inception to April 17, 2025. The reporting quality of PROs was assessed using the CONSORT-PRO extension and the CONSORT 2010 guidelines.
RESULTS: We included 64 RCTs with 8,494 participants. Of these, 14 stu…
Rank104.9
Systematic review or meta-analysis
Journal of bone oncology · 2026 · PMID 42388270
BACKGROUND: Surgery for long bone metastases is performed to alleviate pain, restore function, and improve quality of life. Accurate postoperative survival estimates are essential for surgical planning and shared decision-making, yet no comprehensive synthesis exists across primary tumor types. This systematic review aimed to characterize postoperative survival and its temporal trend in patients undergoing surgery for long bone metastases.
METHODS: A systematic literature search was performed in PubMed, EMBASE, and…
Rank104.5
Systematic review or meta-analysisResult signal: null
World journal of surgical oncology · 2026 · PMID 42050547
BACKGROUND: Transarterial radioembolization (TARE) is increasingly used as an alternate and potentially superior treatment option to Transarterial chemoembolization (TACE) for early- to intermediate-stage unresectable hepatocellular carcinoma (HCC). However, randomized controlled trials (RCTs) comparing the two modalities have reported mixed findings, and the comparative efficacy and safety remain uncertain. METHODS: A comprehensive literature search was conducted across five databases until August 2025, following …
Rank103.8
Systematic review or meta-analysis
Critical reviews in oncology/hematology · 2026 · PMID 42250662
BACKGROUND: Immunotherapy-based regimens are standard first-line treatments for advanced hepatocellular carcinoma (HCC), yet integrated comparisons across efficacy, safety, and quality-of-life (QoL) outcomes remain limited. We performed a network meta-analysis (NMA) to identify the optimal treatment strategy.
METHODS: A literature search was conducted in PubMed, Embase, Cochrane Library, and Scopus to identify phase III randomized controlled trials (RCTs) evaluating immune checkpoint inhibitor (ICI)-based therapies…
Rank101.2
Systematic review or meta-analysis
HPB : the official journal of the International Hepato Pancreato Biliary Association · 2026 · PMID 42436069
BACKGROUND: Histotripsy is an emerging non-thermal, non-invasive focused ultrasound technology. This systematic review aims to evaluate the early clinical safety and efficacy of histotripsy in the treatment of liver malignancies.
METHODS: A systematic search was conducted across Web of Science, Medline, Scopus, and Cochrane CENTRAL up to February 2026. The search strings combined terms for "histotripsy" and "liver tumor/cancer/metastasis". Studies reporting technical success rate or complications of histotripsy for…
Rank92.4
Randomized clinical studyResult signal: benefit
Frontiers in pharmacology · 2026 · PMID 42064805
INTRODUCTION: Huaier granules (HEG), a traditional Chinese medicinal product primarily composed of Trametes robiniophila Murr., have been incorporated into comprehensive treatment strategies for various cancers. When combined with conventional antitumor therapies, it has demonstrated notable adjuvant and synergistic effects, improving quality of life and prolonging survival in patients. This study aimed to systematically review the clinical efficacy, safety, and potential mechanisms of HEG as adjuvant therapy in on…
Rank92.0
Randomized controlled trial
Annals of surgery · 2026 · PMID 39523954
BACKGROUND: Postoperative morbidity can reduce the quality of life, physical performance, and tolerability of postoperative chemotherapy in patients with colorectal liver metastases (CRLM). Exercise can improve these outcomes in some cancer populations. However, it remains unknown whether exercise can be delivered in the early postoperative period after surgery for CRLM without increasing the risk of harm.
OBJECTIVE: The primary objective was to compare the number of serious adverse events (SAEs) in exercise interv…
Rank90.9
Randomized clinical study
The American journal of gastroenterology · 2026 · PMID 42262375
INTRODUCTION: Informal caregivers are critical for the care of patients with end-stage liver disease (ESLD), but few studies have examined their impact on patient-reported outcome measures (PROMs). We aimed to describe the association between caregiver involvement, caregiver burden, and PROMs in a large ESLD cohort.
METHODS: We analyzed the palliative care for liver diseases (PAL-LIVER) cluster randomized trial, which compared 2 models of palliative care for ESLD and/or hepatocellular carcinoma at 19 US sites. Pati…
Rank90.7
Randomized clinical study
Journal of pain research · 2026 · PMID 42058818
BACKGROUND: The current method for managing opioid tolerance is opioid rotation, but its effectiveness is limited. Transcutaneous electrical acupoint stimulation (TEAS) combined therapy has been shown to effectively relieve moderate-to-severe pain in patients with hepatocellular carcinoma (HCC), but there is insufficient evidence regarding its role in modulating opioid tolerance. Additionally, exosomal proteomics can aid in exploring the potential mechanisms of action of TEAS.
METHODS: This single-center, patient-b…
Rank90.0
Randomized clinical study
BMC cancer · 2026 · PMID 42143303
BACKGROUND: In patients with colorectal cancer liver metastases (CRLM), resection of the primary tumour and local treatment of liver metastases may offer a chance of cure or long-term survival. Most patients however present with unresectable CRLM. Hepatic arterial infusion pump (HAIP) therapy with floxuridine (FUDR) combined with systemic therapy (SYST) could enhance conversion to resectable CRLM, reduce recurrences and therefore, probably prolong survival. The aim of this trial is to investigate whether intensifyi…
Rank90.0
Randomized clinical study
Trials · 2026 · PMID 42185926
BACKGROUND/AIM: Hepatocellular carcinoma (HCC) and colorectal cancer liver metastases (CRLM) carry high recurrence rates after surgery or transplantation. Conventional imaging and biomarkers have limited sensitivity for detecting minimal residual disease (MRD). Circulating tumor DNA (ctDNA) is a promising biomarker that may enable earlier recurrence detection compared with standard methods. The aim of this randomized controlled trial is to evaluate the clinical utility of ctDNA monitoring in the early detection of …
Rank89.8
Randomized clinical study
BMJ open · 2026 · PMID 42114858
INTRODUCTION: Electronic patient-reported outcome (ePROs)-based symptom monitoring benefits health-related quality of life (HRQoL) in various cancers. However, despite the high disease and economic burden of hepatocellular carcinoma (HCC) and the complex symptom profile during immunotherapy, the effectiveness and implementation of ePROs-based interventions in this population remain unclear. This study aims to evaluate the clinical and implementation outcomes of ePROs-based symptom monitoring among patients with HCC…
Rank89.2
Randomized clinical study
BMJ open · 2026 · PMID 42264528
INTRODUCTION: Treatment options remain limited for patients with advanced hepatocellular carcinoma (HCC) who experience oligoprogression during first-line systemic therapy (FLST), especially given the modest efficacy and restricted availability of second-line systemic therapy (SLST). This trial aims to evaluate whether continuing FLST combined with radiotherapy (RT) to oligoprogressive lesions can improve progression-free survival (PFS) compared with an early switch to SLST in patients with oligoprogressive HCC whi…
Rank89.1
Randomized clinical study
Contemporary clinical trials · 2026 · PMID 42309387
INTRODUCTION: Liver metastases are common in several malignancies, with only 15-20% of patients eligible for surgical resection. For non-surgical candidates, stereotactic body radiation therapy (SBRT) is an effective alternative with acceptable local control (LC) rates. Higher biologically effective doses (BED10 > 100 Gy10) are associated with improved LC, and single-fraction ultra-high dose SBRT (35-40 Gy) has demonstrated excellent LC with minimal toxicity. MR-guided adaptive SBRT enhances precision and may optim…
Rank85.0
Randomized clinical study
BMJ open · 2026 · PMID 42350004
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive condition that may lead to liver cirrhosis and hepatocellular carcinoma. It is strongly associated with cardiometabolic diseases such as type 2 diabetes (T2D) and obesity. Weight loss is a key therapeutic strategy to treat MASLD. In recent years, there has been increasing attention to weight-reducing medication, but promising dietary interventions-such as early time restricted eating (eTRE)-have also been developed. Whet…
Rank83.1
Phase II clinical trial
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · PMID 42126314
PURPOSE: Evidence for radiotherapy (RT) in oligoprogressive hepatocellular carcinoma (OP-HCC) is limited. We evaluated the efficacy and safety of progression-directed RT (PDRT) alongside ongoing first-line systemic therapy (FLST) in patients with OP-HCC.
PATIENTS AND METHODS: Patients who developed OP-HCC during FLST were enrolled and received PDRT with a biologically effective dose of at least 60 Gy while continuing FLST. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall su…
Rank79.6
Phase II clinical trial
European journal of nuclear medicine and molecular imaging · 2026 · PMID 41699283
PURPOSE: The liver is the commonest site of metastases in neuroendocrine neoplasias (NENs) and is an independent predictor of poor outcome. Selective internal radiation therapy (SIRT) allows selective delivery of high dose radiation to liver tumours and has shown promise in the management of NENs. We determined the safety and efficacy of SIRT for inoperable liver metastases secondary to NENs. Dose-response and dose-toxicity relationship were assessed.
METHODS: A prospective, multicentre, phase 2 study was conducted…
Rank77.7
Multicenter clinical study
BMJ open · 2026 · PMID 42486514
INTRODUCTION: Hepatocellular carcinoma is the sixth most common malignancy worldwide, with immune checkpoint inhibitors transforming treatment paradigms despite modest response rates of approximately 30%. Emotional distress, encompassing depression and anxiety symptoms, affects 30-50% of cancer patients and may influence immunotherapy efficacy through immune system modulation. Recent studies in lung cancer, gastric cancer and melanoma demonstrate associations between pretreatment emotional distress and worse immuno…
Rank73.0
Multicenter clinical study
Hepatobiliary & pancreatic diseases international : HBPD INT · 2026 · PMID 41714230
The prognosis for patients diagnosed with hepatocellular carcinoma with bile duct tumor thrombus (HCC-BDTT) remains dismal, and there are presently no universally accepted treatment guidelines to address this complex condition. Long-term outcomes of liver transplantation (LT) for HCC-BDTT patients are unclear, and whether LT is a proper therapeutic option for HCC-BDTT patients remains to be determined. Therefore, we design a clinical trial to evaluate whether LT can improve recurrence-free survival (RFS) and overal…
Rank54.1
Other PubMed-indexed publication
Hepatology research : the official journal of the Japan Society of Hepatology · 2026 · PMID 41653074
AIM: Hepatic edema indicates a poor prognosis and impaired quality of life in patients with cirrhosis. Tolvaptan is used in Japan to treat patients who do not respond to conventional diuretics. However, the long-term prognostic effect of tolvaptan has not yet been fully determined in large-scale, real-world cohorts.
METHODS: We conducted a retrospective multicenter study of patients with cirrhosis and hepatic edema who were treated with tolvaptan at 17 centers to identify the clinical predictors of treatment respon…
Rank51.0
Other PubMed-indexed publication
EClinicalMedicine · 2026 · PMID 42023169
BACKGROUND: Selective Internal Radiation Therapy with yttrium-90 (Y90) has been used for decades, yet guideline recommendations remain inconsistent. High-quality real-world data is needed to guide practice. The objectives of this study were to evaluate effectiveness, safety, and patient quality of life (QoL) with TheraSphere™ treatment in real-world clinical practice, and to identify clinical and dosimetric factors associated with survival.
METHODS: PROACTIF was a prospective, open label, non-interventional, all-co…
Rank50.0
Other PubMed-indexed publication
Value in health regional issues · 2026 · PMID 42240545
OBJECTIVES: Health related quality of life (HRQoL) in chronic hepatitis B infection (CHB) is poorly studied in Africa despite the high burden of disease. We aimed to assess HRQoL and health utility (HU) across different stages of infection and liver-related disease in The Gambia, West Africa.
METHODS: A cross-sectional study was carried out between January and November 2019. Participants were recruited from outpatient clinics and inpatient wards. Patients were stratified into 5 disease stages CHB not meeting treatm…
Rank49.9
Other PubMed-indexed publication
Annals of surgical oncology · 2026 · PMID 41882262
BACKGROUND: Colorectal liver metastases (CRLM) occur in up to 50% of patients who suffer from colorectal cancer. While liver resection of CRLM remains the only curative treatment option, postoperative complications are common and mitigate the beneficial effects of CRLM resection on quality of life and survival in these patients. Liver fibrosis is a known risk factor for surgical morbidity and mortality after liver surgery. However, preoperative detection of liver fibrosis remains challenging. Noninvasive tests faci…
Rank49.6
Other PubMed-indexed publication
Internal medicine (Tokyo, Japan) · 2026 · PMID 41951413
Background and Aims Covert hepatic encephalopathy (CHE) worsens the quality of life and the prognosis of patients with chronic liver disease (CLD). CHE can be caused by various factors, including age and the etiology of CLD, such as metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to investigate factors associated with CHE in patients with CLD. Methods This retrospective study included 195 patients with CLD. CHE was diagnosed using Stroop test. Hyperammonemia was defined as a plasm…
Rank49.5
Other PubMed-indexed publication
Frontiers in oncology · 2026 · PMID 42038399
PURPOSE: Despite established perioperative guidelines for hepatocellular carcinoma (HCC) resection, inconsistent implementation hinders optimal recovery. This study evaluated clinical outcomes associated with a structured, Nursing-Sensitive Indicator (NSI)-driven quality improvement program designed to ensure reliable execution of evidence-based practices.
PATIENTS AND METHODS: We leveraged a cohort of 172 patients undergoing curative liver resection at The Third Affiliated Hospital of Chongqing Medical University …
Randomized Controlled Trials64 records
Rank110.0
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42285810
BACKGROUND AND AIMS: Statins have been proposed as hepatoprotective agents in chronic liver disease (CLD); however, evidence from existing systematic reviews-including observational studies and clinical trials-is inconsistent and affected by substantial overlap. We conducted an umbrella review to synthesize the available evidence on the associations between statin use and hepatological outcomes in CLD patients, while addressing study overlap.
DESIGN: PubMed, EMBASE, and Cochrane Library were searched up to Septembe…
Rank108.8
Systematic review or meta-analysisResult signal: benefit
Critical reviews in oncology/hematology · 2026 · PMID 41905568
BACKGROUND: Liver metastases have been associated with poor prognosis and potentially diminished immunotherapy benefit. Comprehensive evidence regarding whether liver involvement affects the efficacy of immune checkpoint inhibitor plus chemotherapy regimens remains incomplete.
METHODS: Following PRISMA guidelines, we systematically searched five databases through May 2025 for randomized controlled trials comparing chemoimmunotherapy versus chemotherapy alone in solid tumors, with survival data stratified by liver m…
Rank108.7
Systematic review or meta-analysis
Abdominal radiology (New York) · 2026 · PMID 41364225
OBJECTIVES: Hepatocellular adenomas (HCA) are typically resected if > 5 cm after 6 months due to historical risks of bleeding and malignant transformation. Outcomes of contemporary patients managed with surveillance are not well defined. We performed a systematic review and meta-analysis of patients with HCAs monitored for ≥ 6 months to assess rates of size stability, bleeding, and malignant transformation.
METHODS: PubMed, Web of Science, and Embase databases were searched up to August 2025 for all articles report…
Rank107.7
Systematic review or meta-analysisResult signal: benefit
Frontiers in immunology · 2026 · PMID 42220514
BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized the front-line treatment of advanced hepatocellular carcinoma (HCC). However, the comparative efficacy and safety of different ICI-based regimens-and their consistency across etiologic subgroups [HBV, HCV, and non-HBV/non-HCV (NBNC)]-remain uncertain. This study conducted a Bayesian network meta-analysis (NMA) of recent randomized controlled trials (RCTs) to compare the first-line immunotherapy strategies both overall and by viral etiology.
METHODS…
Rank107.6
Systematic review or meta-analysis
JAMA network open · 2026 · PMID 42084869
IMPORTANCE: Circadian rhythms affect immunity, which could affect the effectiveness of immune checkpoint inhibitor (ICI). Whether the time of ICI administration is associated with clinical outcomes in advanced cancers remains unclear.
OBJECTIVE: To evaluate the association between time of day of ICI administration and oncologic outcomes in patients with advanced solid tumors.
DATA SOURCES: MEDLINE (via PubMed), Embase, and Web of Science Core Collection were searched in February 2026 to identify eligible studies.
S…
Rank107.5
Systematic review or meta-analysisResult signal: harm
Critical reviews in oncology/hematology · 2026 · PMID 42069094
BACKGROUND: The therapeutic landscape of HCC has evolved, with ICI-based combinations progressively replacing TKI monotherapy as standard first-line treatment, although concerns remain regarding their safety profile.
METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ICI-based combinations with TKI monotherapy as first-line treatment for advanced HCC. MEDLINE/PubMed, Scopus and the Cochrane Library were searched through December 1, 2025. The primary endpoint…
Rank107.3
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42203603
BACKGROUND: Hepatocellular carcinoma (HCC) represents a major health burden, historically treated with tyrosine kinase inhibitors (TKIs). The advent of immune checkpoint inhibitors (ICIs) has reshaped treatments, with pivotal trials (IMbrave150 and HIMALAYA) establishing ICI-based combinations as first-line therapy. Traditional statistical metrics may not fully capture the robustness of trial outcomes. The Survival-Inferred Fragility Index (SIFI) quantifies trial stability as the minimum number of additional surviv…
Rank106.4
Systematic review or meta-analysisResult signal: null
Liver international : official journal of the International Association for the Study of the Liver · 2026 · PMID 42003041
BACKGROUND: Systemic therapies have been widely applied in the first-line treatment of patients with unresectable hepatocellular carcinoma (uHCC). Regimens based on programmed cell death 1/ligand 1 (PD-1/PD-L1) inhibitors combined with either bevacizumab or lenvatinib have become first-line treatments, yet the optimal strategy remains controversial. This systematic review and meta-analysis aimed to compare the efficacy and safety of lenvatinib versus bevacizumab, both in combination with PD-1/PD-L1 inhibitors, as f…
Rank106.3
Systematic review or meta-analysisResult signal: null
Journal of clinical gastroenterology · 2026 · PMID 42090574
BACKGROUND: Esophageal variceal bleeding (EVB) is a life-threatening complication of liver cirrhosis. Carvedilol, a nonselective β-blocker with α1-blocking properties, and endoscopic variceal ligation (EVL) are both recommended for prophylaxis, but their comparative performance remains uncertain.
METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted, searching PubMed, Web of Science, and Embase to July 2025. Trials comparing carvedilol with EVL in adults with cirrhosis …
Rank106.0
Systematic review or meta-analysis
Diabetes care · 2026 · PMID 41973508
BACKGROUND: Type 2 diabetes mellitus (T2DM) amplifies liver disease burden, yet the comparative hepatic effects of glucose-lowering drugs remain poorly defined.
PURPOSE: To compare associations between glucose-lowering drug classes and major adverse liver outcomes (MALOs) in adults with T2DM.
DATA SOURCES: PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched from December 1946 through 23 August 2025.
STUDY SELECTION: Studies enrolling adults with T2DM that evaluated associations between …
Rank106.0
Systematic review or meta-analysis
Clinical colorectal cancer · 2026 · PMID 41723037
Colorectal liver metastases (CRLM) remain a leading cause of cancer-related mortality, with recurrence rates of 50 to 70% following curative-intent hepatic resection. Circulating tumor DNA (ctDNA) has emerged as a promising biomarker for minimal residual disease (MRD) detection, yet its prognostic value in resected CRLM has not been systematically quantified. A systematic review and meta-analysis was conducted following PRISMA 2020 guidelines (PROSPERO: CRD420251177140). MEDLINE, Embase, Web of Science, Cochrane CE…
Rank105.8
Systematic review or meta-analysis
Frontiers in immunology · 2026 · PMID 42327777
BACKGROUND: The therapeutic landscape of advanced hepatocellular carcinoma (HCC) has expanded beyond sorafenib, with multiple combination regimens now demonstrating improved outcomes. However, the absence of direct head-to-head comparisons complicates treatment selection in clinical practice.
METHODS: We performed a Bayesian network meta-analysis of phase III randomized controlled trials to compare the efficacy and safety of first-line treatments for patients with advanced HCC. Overall survival (OS), progression-fr…
Rank105.8
Systematic review or meta-analysis
Arquivos de gastroenterologia · 2026 · PMID 42154843
BACKGROUND: Physicians often use caution when prescribing statins to patients with chronic liver disease (CLD) due to potential hepatotoxicity. However, recent evidence indicates that hepatotoxicity is uncommon, and the risks of not using statins may often outweigh those associated with their use. Additionally, recent findings suggest that statins may have clinically beneficial effects on cirrhosis due to their pleiotropic properties.
OBJECTIVE: To evaluate the impact of statin use on the number of patients with ch…
Rank105.4
Systematic review or meta-analysis
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026 · PMID 41490475
Bridging and downstaging are indications for locoregional therapy (LRT) in hepatocellular carcinoma (HCC) within the context of liver transplantation (LT). Stereotactic body radiation therapy (SBRT) is an emerging LRT modality in these settings. We conducted a systematic review and meta-analysis to assess the efficacy and safety of SBRT as bridging or downstaging therapy. A comprehensive search of PubMed, Embase, and Cochrane Library was performed through July 21, 2025. We included randomized and non-randomized stu…
Rank104.8
Systematic review or meta-analysis
Hepatobiliary & pancreatic diseases international : HBPD INT · 2026 · PMID 42177126
BACKGROUND: Neuroendocrine liver metastases (NLMs) from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) significantly impact morbidity and mortality. While surgical resection remains the standard treatment, radiofrequency ablation (RFA) has emerged as an alternative for unresectable cases. This systematic review compared the oncological outcomes of surgical resection and RFA.
DATA SOURCES: A systematic search of PubMed, Web of Science, and Scopus identified studies published between 2014 and 2025. Eligible …
Rank100.0
Systematic review or meta-analysis
The lancet. Gastroenterology & hepatology · 2026 · PMID 41839199
BACKGROUND: Chronic hepatitis B (CHB) affects an estimated 254 million people globally. Historically, WHO and professional society guidelines have recommended treatment for individuals at high risk of disease progression, including those with hepatitis B virus (HBV) DNA concentrations >20 000 IU/mL. Whether individuals at lower risk, including those with HBV DNA <20 000 IU/mL and normal alanine aminotransferase concentrations, benefit from treatment remains uncertain. To inform 2024 WHO guidelines and the potential…
Rank100.0
Systematic review or meta-analysisResult signal: benefit
Frontiers in immunology · 2026 · PMID 42529281
OBJECTIVE: This study aimed to evaluate the first-line treatment patterns and prognostic factors associated with survival in patients with driver gene-negative non-small cell lung cancer (NSCLC) and liver metastases, in order to identify the optimal treatment strategy.
METHODS: A Bayesian network meta-analysis was performed using R software (version 4.2.3) and RevMan (version 5.4) to systematically compare the efficacy of various first-line treatment regimens, including chemotherapy, immunotherapy, and combination …
Rank100.0
Systematic review or meta-analysis
The lancet. Gastroenterology & hepatology · 2026 · PMID 41839198
BACKGROUND: In the 2015 WHO guidelines for chronic hepatitis B (CHB), antiviral therapy was recommended for individuals with cirrhosis and individuals without cirrhosis with persistently elevated alanine aminotransferase (ALT) concentrations and hepatitis B virus (HBV) DNA >20 000 IU/mL, whereas treatment was deferred for individuals with persistently normal ALT concentrations and HBV DNA <2000 IU/mL. To inform 2024 WHO guidelines on CHB and the potential expansion of treatment threshold recommendations, we conduct…
Rank100.0
Systematic review or meta-analysis
Frontiers in endocrinology · 2026 · PMID 42312204
UNLABELLED: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve weight, glycemic control, and cardiometabolic risk factors, but randomized trials have not been powered to determine effects on advanced liver outcomes. We conducted a systematic review and exploratory meta-analysis of peer-reviewed comparative real-world cohort studies in adults with type 2 diabetes (T2D), emphasizing active-comparator designs, clinically advanced liver endpoints, and transparent limits of causal inference. PubMed/MEDLINE and…
Rank99.0
Systematic review or meta-analysis
Hepatobiliary & pancreatic diseases international : HBPD INT · 2026 · PMID 41162227
BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed systemic therapy for hepatocellular carcinoma (HCC), leading to growing interest in their integration into liver transplantation (LT) protocols. Their use in the neoadjuvant and adjuvant settings aims to expand transplant eligibility, improve downstaging and/or bridging options, and reduce tumor recurrence. However, the balance between oncologic benefit and immunologic risk, particularly graft rejection, remains a critical challenge.
DATA SOURCES: A l…
Rank98.3
Randomized controlled trial
Cancer chemotherapy and pharmacology · 2024 · PMID 38374403
PURPOSE: The high recurrence rate of colorectal cancer liver metastasis (CRCLM) after surgery remains a crucial problem. However, adjuvant chemotherapy after hepatectomy for CRCLM has not yet been established. This study evaluated the efficacy of adjuvant therapy with S-1 and oxaliplatin (SOX).
METHODS: In a multicenter, randomized, phase II study, patients undergoing curative resection of CRCLM were randomly enrolled in a 1:1 ratio to either the low- or high-dose group. S-1 and oxaliplatin were administered from d…
Rank97.7
Randomized controlled trial
Maternal & child nutrition · 2026 · PMID 42169402
This study investigated the role of early-life nutrition supplementation in regulating the development of hypothalamic-pituitary-adrenal (HPA) axis activity, as evidenced by hair cortisol concentration (HCC), in the iLiNS-DYAD randomized controlled trial in Ghana. Pregnant women were randomized to one of three conditions: (1) iron and folic acid (IFA) during pregnancy and placebo 0-6 mo postpartum; (2) multiple micronutrients (MMN) during pregnancy and 0-6 mo postpartum; or (3) small-quantity lipid-based nutrient s…
Rank96.7
Randomized controlled trial
The lancet. Gastroenterology & hepatology · 2026 · PMID 42330996
BACKGROUND: Patients with unresectable hepatocellular carcinoma have a poor prognosis and treatments with long-term benefits are needed. Anti-PD-L1 or anti-PD-1 plus anti-VEGF or anti-CTLA-4 double combinations are validated, first-line, systemic immunotherapies. We report the preplanned phase 2 results of the phase 2-3 PRODIGE 81-FFCD 2101-TRIPLET-HCC trial investigating the survival outcomes and safety profile of a triple combination of atezolizumab, bevacizumab, and ipilimumab in a first-line setting.
METHODS: T…
Rank96.4
Randomized controlled trialResult signal: null
European journal of cancer (Oxford, England : 1990) · 2026 · PMID 41833569
BACKGROUND: Stereotactic body radiotherapy (SBRT) has been proven effective for treating small hepatocellular carcinoma (sHCC); however, the comparative efficacy of SBRT and surgical resection remains unknown. This analysis aims to compare the outcomes of SBRT and resection in treating recurrent sHCC.
METHODS: Two randomized controlled trials enrolled recurrent sHCC undergoing resection (NCT01833286) or SBRT (NCT04047173). Patients with single recurrent HCC ≤ 5 cm were included in this study. The primary endpoint w…
Rank96.3
Randomized controlled trialResult signal: null
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026 · PMID 41564372
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we report OS after long-term follow-up. Eligible patients with colorectal adenocarcinoma and an unlimited number of liver metastases were randomized to adjuvant mFOLFOX6 or hepatectomy alone. DFS was the primary endpoint, and OS was a secondary endpoint. Between March 2007 and January 20…
Safety And Adverse Effects60 records
Rank110.0
Systematic review or meta-analysis
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026 · PMID 42285810
BACKGROUND AND AIMS: Statins have been proposed as hepatoprotective agents in chronic liver disease (CLD); however, evidence from existing systematic reviews-including observational studies and clinical trials-is inconsistent and affected by substantial overlap. We conducted an umbrella review to synthesize the available evidence on the associations between statin use and hepatological outcomes in CLD patients, while addressing study overlap.
DESIGN: PubMed, EMBASE, and Cochrane Library were searched up to Septembe…
Rank104.8
Systematic review or meta-analysis
Hepatobiliary & pancreatic diseases international : HBPD INT · 2026 · PMID 42177126
BACKGROUND: Neuroendocrine liver metastases (NLMs) from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) significantly impact morbidity and mortality. While surgical resection remains the standard treatment, radiofrequency ablation (RFA) has emerged as an alternative for unresectable cases. This systematic review compared the oncological outcomes of surgical resection and RFA.
DATA SOURCES: A systematic search of PubMed, Web of Science, and Scopus identified studies published between 2014 and 2025. Eligible …
Rank100.0
Systematic review or meta-analysis
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026 · PMID 42250592
Nicotine, the principal addictive component of tobacco smoke, has traditionally been regarded as non-carcinogenic. However, accumulating evidence over the past two decades has established nicotine as a significant tumor promoter facilitating cancer initiation, progression, metastasis, and therapeutic resistance. This systematic review examines the molecular mechanisms by which nicotine modulates p53-mediated signaling pathways across four major cancer types: lung, gastric, liver, and cervical cancer. In lung cancer…
Rank96.7
Randomized controlled trial
The lancet. Gastroenterology & hepatology · 2026 · PMID 42330996
BACKGROUND: Patients with unresectable hepatocellular carcinoma have a poor prognosis and treatments with long-term benefits are needed. Anti-PD-L1 or anti-PD-1 plus anti-VEGF or anti-CTLA-4 double combinations are validated, first-line, systemic immunotherapies. We report the preplanned phase 2 results of the phase 2-3 PRODIGE 81-FFCD 2101-TRIPLET-HCC trial investigating the survival outcomes and safety profile of a triple combination of atezolizumab, bevacizumab, and ipilimumab in a first-line setting.
METHODS: T…
Rank89.1
Randomized clinical study
Contemporary clinical trials · 2026 · PMID 42309387
INTRODUCTION: Liver metastases are common in several malignancies, with only 15-20% of patients eligible for surgical resection. For non-surgical candidates, stereotactic body radiation therapy (SBRT) is an effective alternative with acceptable local control (LC) rates. Higher biologically effective doses (BED10 > 100 Gy10) are associated with improved LC, and single-fraction ultra-high dose SBRT (35-40 Gy) has demonstrated excellent LC with minimal toxicity. MR-guided adaptive SBRT enhances precision and may optim…
Rank80.1
Phase II clinical trial
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026 · PMID 42385524
AIMS: It is controversial whether monotherapy with immunotherapeutics is effective in early-stage hepatocellular carcinoma (HCC). We evaluated immunotherapy monotherapy as an initial neoadjuvant strategy.
METHODS: This prospective, single-arm, phase II trial of an adaptive neoadjuvant strategy enrolled patients with resectable, early-stage HCC. All patients received tislelizumab monotherapy; non-responders received subsequent lenvatinib combination therapy preoperatively.
RESULTS: For the overall efficacy of all 36…
Rank79.3
Multicenter clinical study
International journal of cancer · 2026 · PMID 41882494
Patients with liver metastases generally have poorer outcomes following immunotherapy compared with those without liver involvement, and whether local ablation can enhance systemic antitumor immunity remains unclear. In this retrospective study, we evaluated the efficacy of combining ablation with PD-1 inhibitor therapy versus PD-1 inhibitor monotherapy in patients with liver metastases. A total of 1337 patients who received PD-1 inhibitors with or without ablation between January 2017 and September 2022 at three i…
Rank79.0
Multicenter clinical studyResult signal: null
Liver international : official journal of the International Association for the Study of the Liver · 2026 · PMID 42478167
BACKGROUND & AIMS: We compared multibipolar radiofrequency ablation (mbpRFA) with open liver resection (OLR) or laparoscopic liver resection (LLR) in patients with HCCs within Milan.
METHODS: This multicenter cohort study included patients treated by mbpRFA, OLR or LLR for HCC within the Milan Criteria, developed on advanced fibrosis in nine French centres between 2008 and 2018. Adjustments on HCC size/number, gender, age, ASA, HCV, HBV, metabolic syndrome, chronic alcohol intake, MELD score, serum AFP level, APRI …
Rank77.7
Multicenter clinical study
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026 · PMID 42296572
OBJECTIVE AND BACKGROUND: The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a subject of clinical controversy. This study aimed to evaluate the safety and efficacy of one-stage hepatectomy (OSH) versus Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) and to validate the feasibility of OSH by benchmarking it against the standar…
Rank73.0
Multicenter clinical studyResult signal: null
Anticancer research · 2026 · PMID 42527085
BACKGROUND/AIM: Durvalumab plus tremelimumab (DT) therapy has demonstrated overall survival benefit in a clinical trial and is now widely used as first-line treatment for unresectable hepatocellular carcinoma (u-HCC). However, evidence supporting the efficacy of lenvatinib (LEN) as subsequent therapy after DT progression remains limited.
PATIENTS AND METHODS: This multicenter study enrolled patients who received LEN as first-line therapy (1st-line LEN) and those who received LEN as second-line therapy following DT …
Rank49.9
Other PubMed-indexed publication
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2026 · PMID 41660702
BACKGROUND: Antiviral therapies for hepatitis B or C virus may be associated with reduced risk of tumor recurrence and mortality of patients with hepatocellular carcinoma (HCC) undergoing curative treatments, compared to untreated patients. Previous studies comparing survival outcomes between percutaneous radiofrequency ablation (RFA) and liver resection (LR) for treating patients with very early-stage HCC did not evaluate the effects of antiviral treatments on survival outcome. Our study aimed to clarify this issu…
Rank49.6
Other PubMed-indexed publication
International journal of cardiology. Congenital heart disease · 2026 · PMID 42434196
BACKGROUND: Fontan associated liver disease (FALD) is a known complication in adult patients with total cavo-pulmonary connection. The relationship between the severity of FALD and cardiovascular disease progression is yet to be clarified. We investigated the role of liver stiffness measured by transient elastography (TE) in predicting adverse events (AEs) in adult patients with Fontan circulation.
MATERIAL AND METHODS: We retrospectively analysed TE data from our cohort of Fontan patients from September 2014 to De…
Rank49.5
Other PubMed-indexed publication
European journal of nuclear medicine and molecular imaging · 2026 · PMID 42209817
BACKGROUND: EPOCH demonstrated superior progression free survival using yttrium-90 [90Y] glass microspheres radioembolization plus chemotherapy versus chemotherapy in colorectal cancer patients with liver metastases who had progressed following first-line oxaliplatin or irinotecan-based chemotherapy. Exploratory post-hoc analyses and theoretical modeling assessed the potential impact of dosimetry on safety outcomes.
PATIENTS AND METHODS: Liver-related treatment-emergent adverse event (TEAE) frequency and/or severit…
Rank49.2
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42449202
OBJECTIVE: Microwave ablation (MWA) is a minimally invasive therapy for liver metastases. Image guidance, primarily ultrasound (US) and computed tomography (CT), is critical for precision, but their comparative safety profiles remain debated. This study aims to compare the incidence and severity of complications between US-guided and CT-guided MWA in patients with liver metastases.
METHODS: After propensity score matching (PSM), retrospective analysis of 120 patients (2022-2024) undergoing US-guided (n = 60) or CT-…
Rank49.2
Other PubMed-indexed publication
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026 · PMID 42439025
PURPOSE: To evaluate the efficacy and safety of transarterial embolization (TAE) sequential microwave ablation (MWA) for hepatic hemangioma (HH).
METHODS: This single-center retrospective study included 122 patients with 134 HHs treated from 2013 to 2024. TAE was followed by CT-guided MWA after 3-14 days. Technical efficacy was defined as ≥50% HH volume reduction at 6 months post-ablation. Hemoglobinuria within 24 h after MWA was analyzed as a safety outcome. Correlation analysis was used to avoid simultaneous incl…
Rank49.1
Other PubMed-indexed publication
European journal of nuclear medicine and molecular imaging · 2026 · PMID 42201381
PURPOSE: Accurate preoperative risk stratification for post-hepatectomy liver failure (PHLF) is crucial. This study aimed to investigate whether, in patients deemed eligible for safe resection by conventional clinical criteria, ⁶⁸Ga-FAPI-04 PET/CT-based quantitative assessment of liver fibrosis could serve as a non-invasive predictor for PHLF.
METHODS: In this retrospective study, 107 patients with liver cancer underwent preoperative ⁶⁸Ga-FAPI-04 PET/CT. Quantitative parameters, including liver SUVmax, SUVmean, SUV…
Rank48.8
Other PubMed-indexed publication
Surgery · 2026 · PMID 42269209
BACKGROUND: The Baveno VII consensus recently defined recompensation in patients with decompensated cirrhosis. Whether hepatectomy is a viable option for recompensated patients remains uncertain. The purpose of this retrospective study was to evaluate the efficacy and safety of hepatectomy of hepatitis B-related hepatocellular carcinoma with recompensated cirrhosis.
METHODS: Clinical data of patients with hepatitis B-related hepatocellular carcinoma who underwent hepatectomies between January 2011 and December 2022…
Rank48.6
Other PubMed-indexed publication
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026 · PMID 42203104
BACKGROUND: Accurate identification of the midplane (Cantlie's line) is essential for anatomical liver resections, but conventional inflow control is often challenging because of adhesions, tumors, or anatomical variations. We developed a simple technique involving temporary clamping of the right side of the hilar plate using a laparoscopic grasper, covering at least the posterior extremity of the cystic plate anteriorly and the right half of the hepatoduodenal ligament posteriorly, for early identification of the …
Rank48.6
Other PubMed-indexed publication
Clinics and research in hepatology and gastroenterology · 2026 · PMID 42385878
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a major cause of cancer-related mortality worldwide. This study aimed to evaluate the safety and efficacy of hepatic artery infusion chemotherapy (HAIC) combined with camrelizumab and apatinib in patients with advanced HCC. A retrospective analysis was conducted on patients with advanced HCC who received either camrelizumab plus apatinib (n = 65) or HAIC combined with camrelizumab and apatinib (n = 65). Objective response rate (O…
Rank48.2
Other PubMed-indexed publication
Oncology letters · 2026 · PMID 42491366
Hepatocellular carcinoma (HCC) with inferior vena cava and/or right atrial tumor thrombus (IVC/RA TT) is associated with extremely poor prognosis, and the optimal non-surgical treatment approach remains unclear. The current retrospective cohort study aimed to evaluate the efficacy of multidisciplinary team (MDT)-guided non-surgical management in 41 patients with HCC and IVC/RA TT treated at West China Hospital (Sichuan University, Chengdu, China) between January 2019 and December 2023. Patients were categorized acc…
Rank48.2
Other PubMed-indexed publication
Anticancer research · 2026 · PMID 42527069
BACKGROUND/AIM: Minimally invasive liver resection (MILR) of the posterosuperior segments (segments 7 and 8) for hepatocellular carcinoma (HCC) remains technically challenging. This study aimed to compare the perioperative and oncological outcomes between MILR and open liver resection (OLR) using propensity score matching.
PATIENTS AND METHODS: A total of 157 consecutive patients underwent liver resection for HCC located in segments 7 and/or 8 at our institution between January 2010 and February 2026 [80 MILR (58 l…
Rank48.2
Other PubMed-indexed publication
Clinical imaging · 2026 · PMID 42190470
PURPOSE: Portal hypertension is a prognostically unfavorable complication in settings of hepatic malignancy. A transjugular intrahepatic portosystemic shunt (TIPS), or a direct intrahepatic portocaval shunt (DIPS), may be considered if a patient develops refractory or life-threatening symptoms. Given blood vessel disruption and new portal outflow directly to the heart after TIPS/DIPS, the risk of post-procedure pulmonary metastasis should be considered. This study evaluates the safety and efficacy of portosystemic …
Rank48.0
Other PubMed-indexed publication
Journal of clinical and experimental hepatology · 2026 · PMID 42519550
OBJECTIVE: Stereotactic body radiotherapy (SBRT) has emerged as a noninvasive local treatment option for patients who are not candidates for surgical resection or locoregional therapies; however, data on its safety and efficacy in patients with Child-Turcotte-Pugh (CTP) B liver dysfunction are limited. The primary aim of this study was to evaluate the safety and efficacy of SBRT in HCC patients with CTP-B liver dysfunction. Secondary objectives included the assessment of survival outcomes.
METHODS: This study inclu…
Rank47.4
Other PubMed-indexed publication
Clinical genitourinary cancer · 2026 · PMID 42400955
INTRODUCTION: Primary mediastinal pure seminoma is a rare extragonadal germ cell tumor with limited contemporary data. We aimed to characterize treatment patterns and oncologic outcomes in patients treated at a tertiary center.
METHODS: We conducted a retrospective cohort study of patients with primary mediastinal pure seminoma treated from 1994 to 2025 using our institution's Germ Cell Tumor Database. Clinical characteristics, treatment, recurrence, and toxicity were evaluated. Progression-free survival (PFS) and …
Rank47.4
Other PubMed-indexed publication
Pakistan journal of pharmaceutical sciences · 2026 · PMID 42262196
BACKGROUND: Long-term immunosuppression from transplants which reduces the body's ability to detect and fight the tumor, is the main reason hepatocellular carcinoma (HCC) often recurs.
OBJECTIVES: This study evaluates the ability of lenvatinib (used to manage angiogenesis) and an anti-PD-L1 agent to help treat recurrent or new liver cancer in patients who have undergone LT.
METHODS: Participants of this retrospective cohort study included 15 people who had received a transplant and were treated with low-dose tacrol…
Treatments That Failed Clinical Trials60 records
Rank101.3
Randomized controlled trialResult signal: null
JAMA · 2024 · PMID 39158894
IMPORTANCE: Tranexamic acid reduces bleeding and blood transfusion in many types of surgery, but its effect in patients undergoing liver resection for a cancer-related indication remains unclear.
OBJECTIVE: To determine whether tranexamic acid reduces red blood cell transfusion within 7 days of liver resection.
DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized clinical trial of tranexamic acid vs placebo conducted from December 1, 2014, to November 8, 2022, at 10 hepatopancreaticobiliary sites in Canada and…
Rank98.1
Randomized controlled trialResult signal: mixed
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025 · PMID 40554738
PURPOSE: We conducted a randomized controlled trial (SURF-RCT) to evaluate the efficacy of surgery versus radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Simultaneously, eligible patients who dissented from random assignment were enrolled in a nonrandomized prospective observational trial (SURF-Cohort). We aimed to report the final analyses of overall survival (OS) and updated recurrence-free survival (RFS) in the SURF-RCT and SURF-Cohort trials.
METHODS: The trials were conducted in 49 institutio…
Rank97.7
Randomized controlled trialResult signal: null
La Radiologia medica · 2024 · PMID 39495436
PURPOSE: This multicenter prospective study aims to compare transradial access versus transfemoral access in conventional transarterial chemoembolization (c-TACE) procedures, focusing on operators radiations exposure, patients comfort, technical success and vascular access complications.
MATERIALS AND METHODS: Patients were affected by hepatocellularcarcinoma (HCC) in intermediate stage or previous stages unfit for ablation and/or surgery; they were randomized into two groups according to arterial access site (Grou…
Rank97.5
Randomized controlled trialResult signal: null
Anaesthesia · 2025 · PMID 39776101
BACKGROUND: While evidence from preclinical and observational cohort studies have suggested potential disparities in tumour behaviour associated with the choice of intra-operative anaesthetics, clinical evidence of tumour recurrence and metastasis remains inconclusive. We aimed to compare the impact of intra-operative anaesthesia on oncologic outcomes following hepatectomy for hepatocellular carcinoma.
METHODS: Adult patients scheduled for elective hepatectomy for hepatocellular carcinoma were assigned randomly (1:…
Rank97.5
Randomized controlled trialResult signal: benefit
Cancer immunology, immunotherapy : CII · 2026 · PMID 41591582
BACKGROUND: Most adjuvant therapies for hepatocellular carcinoma (HCC) have failed except for autologous cytokine-induced killer (CIK) therapy, which prolonged recurrence-free survival (RFS) in a previously reported randomized controlled trial (RCT) and real-world data (RWD).
METHODS: This study aimed to assess the long-term outcomes of adjuvant CIK therapy using both an extended follow-up of the original RCT and a retrospective cohort study. An extended follow-up analysis of the RCT included 226 patients (114 in t…
Rank97.3
Randomized controlled trialResult signal: null
The British journal of surgery · 2025 · PMID 39991838
BACKGROUND: Venous thrombosis represents a significant complication after deceased-donor liver transplantation, yet there are currently no established protocols for thromboprophylaxis after deceased-donor liver transplantation. The aim of this study was to evaluate the efficacy and safety of prophylactic anticoagulation in patients undergoing deceased-donor liver transplantation.
METHODS: A dual-centre RCT of patients assigned to receive either enoxaparin or normal saline after liver transplantation was conducted. …
Rank97.0
Randomized controlled trialResult signal: null
European journal of medical research · 2025 · PMID 41163129
BACKGROUND AND AIMS: Donafenib, a deuterium-modified sorafenib derivative, has improved survival outcomes in patients with advanced hepatocellular carcinoma (HCC). This study aimed to investigate the treatment-related adverse events and their associations with overall survival (OS) and time to progression (TTP) in patients with advanced HCC treated with donafenib.
METHODS: In this retrospective analysis, data from 334 patients with unresectable or metastatic HCC who had a Child-Pugh liver function score ≤ 7 and had…
Rank97.0
Randomized controlled trialCorrection flagged
The Lancet. Oncology · 2025 · PMID 39848272
BACKGROUND: For patients with small-size colorectal liver metastases, growing evidence suggests thermal ablation to be associated with fewer adverse events and faster recovery than resection while also challenging resection in terms of local control and overall survival. This study assessed the potential non-inferiority of thermal ablation compared with surgical resection in patients with small-size resectable colorectal liver metastases.
METHODS: Adult patients (aged ≥18 years) from 14 centres in the Netherlands, …
Rank96.7
Randomized controlled trialResult signal: mixed
Surgical endoscopy · 2025 · PMID 39994051
BACKGROUND: Low muscle mass is negatively associated with survival in patients undergoing surgery for colorectal cancer. Current evidence is limited regarding whether the surgical approach for liver resection of colorectal metastasis impacts postoperative changes in body composition and whether preoperative body composition can impact complication rate and survival.
METHOD: This study included patients previously included in the randomized OSLO-COMET trail where patients was allocated to laparoscopic or open liver …
Rank96.6
Randomized controlled trialResult signal: null
Scientific reports · 2025 · PMID 41286133
To investigate the effectiveness of TACE in combination with anlotinib and sintilimab in the treatment of unresectable hepatocellular carcinoma. A total of 210 patients with primary unresectable hepatocellular carcinoma (PAC) in our hospital from January 2020 to December 2023 were selected as the study subjects, and they were divided into two groups of 105 cases each by the envelope method using sequentially numbered, opaque sealed envelopes containing computer-generated random allocations. The control group was tr…
Rank96.4
Randomized controlled trialResult signal: null
European journal of cancer (Oxford, England : 1990) · 2026 · PMID 41833569
BACKGROUND: Stereotactic body radiotherapy (SBRT) has been proven effective for treating small hepatocellular carcinoma (sHCC); however, the comparative efficacy of SBRT and surgical resection remains unknown. This analysis aims to compare the outcomes of SBRT and resection in treating recurrent sHCC.
METHODS: Two randomized controlled trials enrolled recurrent sHCC undergoing resection (NCT01833286) or SBRT (NCT04047173). Patients with single recurrent HCC ≤ 5 cm were included in this study. The primary endpoint w…
Rank96.3
Randomized controlled trialResult signal: mixed
Scandinavian journal of gastroenterology · 2024 · PMID 39154241
OBJECTIVE: This study compared the efficacy and safety of the transarterial chemoembolization with CalliSpheres® drug-eluting beads loading with doxorubicin (DEB-TACE) versus conventional lipiodol (cTACE) in patients with unresectable hepatocellular carcinoma (HCC).
METHODS: A randomized controlled trial (RCT) was conducted with 144 patients, who were randomly assigned to receive either DEB-TACE with doxorubicin-loaded CalliSpheres® microspheres or cTACE with doxorubicin-lipiodol emulsion. Patients were followed up…
Rank96.0
Randomized controlled trial
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025 · PMID 40935954
OBJECTIVE: This study aimed to explore the effect of nursing intervention based on the broaden-and-build theory on the psychosocial adaptability of patients with minimally invasive ablation of liver cancer.
METHOD: A total of 100 patients with liver cancer undergoing minimally invasive ablation were selected and randomly divided into two groups. The control group consisted of 50 patients who received routine nursing intervention and Health education. The intervention group consisted of 50 patients who received nurs…
Rank96.0
Randomized controlled trialResult signal: null
Cardiovascular and interventional radiology · 2026 · PMID 41572025
PURPOSE: To compare the patency outcomes and safety profile between the modified TR Band and the PreludeSYNC DISTAL (PSD) for hemostasis following distal transradial access (dTRA) for transarterial chemoembolization (TACE).
METHODS: This prospective randomized trial enrolled 104 participants undergoing TACE via dTRA (143 procedures, all performed using a 4-Fr catheter. Participants achieved hemostasis with either the modified TR Band (n = 74) or PSD (n = 69). The primary endpoint was the incidence of radial artery …
Rank95.9
Randomized controlled trialResult signal: null
The Kaohsiung journal of medical sciences · 2026 · PMID 40888625
Hepatocellular carcinoma (HCC) surveillance with semi-annual ultrasound (US) is recommended for high-risk patients. This study investigates the impact of hepatobiliary abbreviated magnetic resonance imaging (AMRI) performed annually on the recommended US surveillance. Patients with compensated liver cirrhosis at regular HCC surveillance using US and alpha-fetoprotein, with adequate renal function and without HCC diagnosis, were enrolled. Patients were randomized into add-on hepatobiliary AMRI and continuous US surv…
Rank95.9
Randomized controlled trialResult signal: mixed
International journal of surgery (London, England) · 2024 · PMID 38377058
PURPOSE: Hepatocellular carcinoma (HCC) is a significant health concern, and the complexity of liver anatomy poses challenges in conveying radiologic findings and surgical plans to patients. This study aimed to evaluate the impact of a virtual reality (VR) education program on anxiety and knowledge in HCC patients undergoing hepatic resection.
METHOD: From 1 January 2022 to 28 February 2023, 88 patients were enrolled in a randomized controlled trial, divided into the VR group ( n =44) and the control group ( n =44)…
Rank95.9
Randomized controlled trial
Journal of clinical anesthesia · 2024 · PMID 38851003
STUDY OBJECTIVE: To determine if single-injection bilateral posterior quadratus lumborum block (QLB) with ropivacaine would improve postoperative analgesia in the first 24 h after laparoscopic hepatectomy, compared with 0.9% saline.
DESIGN: Prospective, double blinded, randomized controlled trial.
SETTING: A single tertiary care center from November 2021 and January 2023.
PATIENTS: A total of 94 patients scheduled to undergo laparoscopic hepatectomy due to hepatocellular carcinoma.
INTERVENTIONS: Ninety-four patien…
Rank95.9
Randomized controlled trialResult signal: null
European journal of cancer (Oxford, England : 1990) · 2025 · PMID 39644535
BACKGROUND: Hepatic artery infusion (HAI) chemotherapy, particularly with floxuridine (FUDR), has previously shown effectiveness in improving recurrence-free survival (RFS) in colorectal cancer (CRC) patients with colorectal liver metastases (CRLM). Nonetheless, its adjuvant use alongside modern systemic chemotherapy remains unevaluated.
PATIENTS AND METHODS: The HARVEST trial is an open-label, randomized, controlled study conducted from May 2018 to August 2021. CRC patients with resectable primary tumors and CRLM …
Rank95.9
Randomized controlled trialResult signal: mixed
Hepatobiliary & pancreatic diseases international : HBPD INT · 2026 · PMID 41390276
BACKGROUND: Successful liver resection in oncologic surgery depends on safety, precision, and efficacy, all of which require a thorough understanding of liver anatomy. Contrast-enhanced computed tomography (CT)-generated three-dimensional (3D) models have been proposed as a valuable tool to enhance this understanding. However, a systematic comparison of different display modalities across professional groups has not yet been performed.
METHODS: In this prospective, monocentric randomized trial, we compared high-res…
Rank95.8
Randomized controlled trialResult signal: null
Medicine · 2025 · PMID 39993117
BACKGROUND: This study investigated the application of a composite warming strategy in the perioperative care of patients who underwent open hepatectomy for liver cancer. The clinical efficacy of the composite warming strategy was observed and analyzed, and the factors causing hypothermia were discussed.
METHODS: From January 2020 to December 2021, 80 patients were selected for the study. The control group adopted perioperative forced-air warming measures, while the experimental group implemented a composite warmin…
Rank95.8
Randomized controlled trialResult signal: null
Current medical science · 2024 · PMID 39565503
OBJECTIVE: This prospective randomized controlled study was conducted to evaluate the safety and efficacy of the Pringle hepatic hilar occlusion with a bulldog clamp in laparoscopic liver resection.
METHODS: From March 1, 2020 to July 31, 2021, 80 patients were enrolled, including 40 undergoing intraperitoneal Pringle maneuver (IPM) and 40 extraperitoneal Pringle maneuver (EPM). The observation indices included basic preoperative clinical characteristics and intraoperative and postoperative liver function indices.
…
Rank95.7
Randomized controlled trialResult signal: null
PLoS medicine · 2024 · PMID 38728364
BACKGROUND: It remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes in a cohort of RAS/BRAF wild-type colorectal cancer (CRC) patients with initially unresectable colorectal liver metastases (CRLM). To that end, we sought to comparatively evaluate the efficacy and safety of cetuximab plus FOLFOXIRI (triplet arm) versus cetuximab plus FOLFOX (doublet arm) as a conversion regimen (i.e., unresectable to resectable) in CRC patients with u…
Rank95.6
Randomized controlled trialResult signal: harm
Experimental oncology · 2026 · PMID 41788066
UNLABELLED: The aim of the study was to evaluate the impact of quadratus lumborum block (QL block) compared to epidural analgesia (EA) on the postoperative liver functional recovery, coagulation profile, metabolic changes, and hemodynamic stability in patients undergoing liver resection for colorectal liver metastases.
MATERIALS AND METHODS: This prospective randomized study included 64 patients allocated in a 1:1 ratio to EA or QL block groups. 56 patients (28 per group) were included in the final analysis. The pr…
Rank95.4
Randomized controlled trialResult signal: null
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2024 · PMID 38065541
PURPOSE: To compare the therapeutic response and clinical outcome of CT-guided percutaneous microwave (MWA) and radiofrequency ablation (RFA) for the treatment of small- and medium-sized HCC.
MATERIALS AND METHODS: In this prospective trial, 50 patients with HCC were randomly assigned to MWA or RFA treatment. MRI was performed 24 h before and after ablation and subsequently in 3-month intervals. Ablation volumes, ablation durations, adverse events (AE), technique efficacy, technical success, local tumor progression…
Rank95.4
Randomized controlled trial
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2025 · PMID 39978353
To determine whether performing a temporary hepatic hilar nerve block in patients undergoing microwave or radiofrequency ablation of primary or secondary hepatic malignancies reduces the requirement for intravenous conscious procedural sedation and analgesia.Fifty patients undergoing percutaneous image-guided liver thermal ablation were included in this single-center prospective randomized controlled trial. The experimental arm received a hepatic hilar nerve block in addition to intravenous medication directly befo…
i
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